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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The International Society for Bipolar Disorders (ISBD) Task Force Report on Antidepressant Use in Bipolar Disorders</title><author><name sortKey="Pacchiarotti, Isabella" sort="Pacchiarotti, Isabella" uniqKey="Pacchiarotti I" first="Isabella" last="Pacchiarotti">Isabella Pacchiarotti</name></author><author><name sortKey="Bond, David J" sort="Bond, David J" uniqKey="Bond D" first="David J." last="Bond">David J. Bond</name></author><author><name sortKey="Baldessarini, Ross J" sort="Baldessarini, Ross J" uniqKey="Baldessarini R" first="Ross J." last="Baldessarini">Ross J. Baldessarini</name></author><author><name sortKey="Nolen, Willem A" sort="Nolen, Willem A" uniqKey="Nolen W" first="Willem A." last="Nolen">Willem A. Nolen</name></author><author><name sortKey="Grunze, Heinz" sort="Grunze, Heinz" uniqKey="Grunze H" first="Heinz" last="Grunze">Heinz Grunze</name></author><author><name sortKey="Licht, Rasmus W" sort="Licht, Rasmus W" uniqKey="Licht R" first="Rasmus W." last="Licht">Rasmus W. Licht</name></author><author><name sortKey="Post, Robert M" sort="Post, Robert M" uniqKey="Post R" first="Robert M." last="Post">Robert M. Post</name></author><author><name sortKey="Berk, Michael" sort="Berk, Michael" uniqKey="Berk M" first="Michael" last="Berk">Michael Berk</name></author><author><name sortKey="Goodwin, Guy M" sort="Goodwin, Guy M" uniqKey="Goodwin G" first="Guy M." last="Goodwin">Guy M. Goodwin</name></author><author><name sortKey="Sachs, Gary S" sort="Sachs, Gary S" uniqKey="Sachs G" first="Gary S." last="Sachs">Gary S. Sachs</name></author><author><name sortKey="Tondo, Leonardo" sort="Tondo, Leonardo" uniqKey="Tondo L" first="Leonardo" last="Tondo">Leonardo Tondo</name></author><author><name sortKey="Findling, Robert L" sort="Findling, Robert L" uniqKey="Findling R" first="Robert L." last="Findling">Robert L. Findling</name></author><author><name sortKey="Youngstrom, Eric A" sort="Youngstrom, Eric A" uniqKey="Youngstrom E" first="Eric A." last="Youngstrom">Eric A. Youngstrom</name></author><author><name sortKey="Tohen, Mauricio" sort="Tohen, Mauricio" uniqKey="Tohen M" first="Mauricio" last="Tohen">Mauricio Tohen</name></author><author><name sortKey="Undurraga, Juan" sort="Undurraga, Juan" uniqKey="Undurraga J" first="Juan" last="Undurraga">Juan Undurraga</name></author><author><name sortKey="Gonzalez Pinto, Ana" sort="Gonzalez Pinto, Ana" uniqKey="Gonzalez Pinto A" first="Ana" last="González-Pinto">Ana González-Pinto</name></author><author><name sortKey="Goldberg, Joseph F" sort="Goldberg, Joseph F" uniqKey="Goldberg J" first="Joseph F." last="Goldberg">Joseph F. Goldberg</name></author><author><name sortKey="Yildiz, Ay Egul" sort="Yildiz, Ay Egul" uniqKey="Yildiz A" first="Ay Egül" last="Yildiz">Ay Egül Yildiz</name></author><author><name sortKey="Altshuler, Lori L" sort="Altshuler, Lori L" uniqKey="Altshuler L" first="Lori L." last="Altshuler">Lori L. Altshuler</name></author><author><name sortKey="Calabrese, Joseph R" sort="Calabrese, Joseph R" uniqKey="Calabrese J" first="Joseph R." last="Calabrese">Joseph R. Calabrese</name></author><author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B." last="Mitchell">Philip B. Mitchell</name></author><author><name sortKey="Thase, Michael E" sort="Thase, Michael E" uniqKey="Thase M" first="Michael E." last="Thase">Michael E. Thase</name></author><author><name sortKey="Koukopoulos, Athanasios" sort="Koukopoulos, Athanasios" uniqKey="Koukopoulos A" first="Athanasios" last="Koukopoulos">Athanasios Koukopoulos</name></author><author><name sortKey="Colom, Francesc" sort="Colom, Francesc" uniqKey="Colom F" first="Francesc" last="Colom">Francesc Colom</name></author><author><name sortKey="Frye, Mark A" sort="Frye, Mark A" uniqKey="Frye M" first="Mark A." last="Frye">Mark A. Frye</name></author><author><name sortKey="Malhi, Gin S" sort="Malhi, Gin S" uniqKey="Malhi G" first="Gin S." last="Malhi">Gin S. Malhi</name></author><author><name sortKey="Fountoulakis, Konstantinos N" sort="Fountoulakis, Konstantinos N" uniqKey="Fountoulakis K" first="Konstantinos N." last="Fountoulakis">Konstantinos N. Fountoulakis</name></author><author><name sortKey="Vazquez, Gustavo" sort="Vazquez, Gustavo" uniqKey="Vazquez G" first="Gustavo" last="Vázquez">Gustavo Vázquez</name></author><author><name sortKey="Perlis, Roy H" sort="Perlis, Roy H" uniqKey="Perlis R" first="Roy H." last="Perlis">Roy H. Perlis</name></author><author><name sortKey="Ketter, Terence A" sort="Ketter, Terence A" uniqKey="Ketter T" first="Terence A." last="Ketter">Terence A. Ketter</name></author><author><name sortKey="Cassidy, Frederick" sort="Cassidy, Frederick" uniqKey="Cassidy F" first="Frederick" last="Cassidy">Frederick Cassidy</name></author><author><name sortKey="Akiskal, Hagop" sort="Akiskal, Hagop" uniqKey="Akiskal H" first="Hagop" last="Akiskal">Hagop Akiskal</name></author><author><name sortKey="Azorin, Jean Michel" sort="Azorin, Jean Michel" uniqKey="Azorin J" first="Jean-Michel" last="Azorin">Jean-Michel Azorin</name></author><author><name sortKey="Valenti, Marc" sort="Valenti, Marc" uniqKey="Valenti M" first="Marc" last="Valentí">Marc Valentí</name></author><author><name sortKey="Mazzei, Diego Hidalgo" sort="Mazzei, Diego Hidalgo" uniqKey="Mazzei D" first="Diego Hidalgo" last="Mazzei">Diego Hidalgo Mazzei</name></author><author><name sortKey="Lafer, Beny" sort="Lafer, Beny" uniqKey="Lafer B" first="Beny" last="Lafer">Beny Lafer</name></author><author><name sortKey="Kato, Tadafumi" sort="Kato, Tadafumi" uniqKey="Kato T" first="Tadafumi" last="Kato">Tadafumi Kato</name></author><author><name sortKey="Mazzarini, Lorenzo" sort="Mazzarini, Lorenzo" uniqKey="Mazzarini L" first="Lorenzo" last="Mazzarini">Lorenzo Mazzarini</name></author><author><name sortKey="Martinez Aran, Anabel" sort="Martinez Aran, Anabel" uniqKey="Martinez Aran A" first="Anabel" last="Martínez-Aran">Anabel Martínez-Aran</name></author><author><name sortKey="Parker, Gordon" sort="Parker, Gordon" uniqKey="Parker G" first="Gordon" last="Parker">Gordon Parker</name></author><author><name sortKey="Souery, Daniel" sort="Souery, Daniel" uniqKey="Souery D" first="Daniel" last="Souery">Daniel Souery</name></author><author><name sortKey="Ozerdem, Ay Egul" sort="Ozerdem, Ay Egul" uniqKey="Ozerdem A" first="Ay Egül" last="Özerdem">Ay Egül Özerdem</name></author><author><name sortKey="Mcelroy, Susan L" sort="Mcelroy, Susan L" uniqKey="Mcelroy S" first="Susan L." last="Mcelroy">Susan L. Mcelroy</name></author><author><name sortKey="Girardi, Paolo" sort="Girardi, Paolo" uniqKey="Girardi P" first="Paolo" last="Girardi">Paolo Girardi</name></author><author><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name></author><author><name sortKey="Yatham, Lakshmi N" sort="Yatham, Lakshmi N" uniqKey="Yatham L" first="Lakshmi N." last="Yatham">Lakshmi N. Yatham</name></author><author><name sortKey="Zarate, Carlos A" sort="Zarate, Carlos A" uniqKey="Zarate C" first="Carlos A." last="Zarate">Carlos A. Zarate</name></author><author><name sortKey="Nierenberg, Andrew A" sort="Nierenberg, Andrew A" uniqKey="Nierenberg A" first="Andrew A." last="Nierenberg">Andrew A. Nierenberg</name></author><author><name sortKey="Birmaher, Boris" sort="Birmaher, Boris" uniqKey="Birmaher B" first="Boris" last="Birmaher">Boris Birmaher</name></author><author><name sortKey="Kanba, Shigenobu" sort="Kanba, Shigenobu" uniqKey="Kanba S" first="Shigenobu" last="Kanba">Shigenobu Kanba</name></author><author><name sortKey="El Mallakh, Rif S" sort="El Mallakh, Rif S" uniqKey="El Mallakh R" first="Rif S." last="El-Mallakh">Rif S. El-Mallakh</name></author><author><name sortKey="Serretti, Alessandro" sort="Serretti, Alessandro" uniqKey="Serretti A" first="Alessandro" last="Serretti">Alessandro Serretti</name></author><author><name sortKey="Rihmer, Zoltan" sort="Rihmer, Zoltan" uniqKey="Rihmer Z" first="Zoltan" last="Rihmer">Zoltan Rihmer</name></author><author><name sortKey="Young, Allan H" sort="Young, Allan H" uniqKey="Young A" first="Allan H." last="Young">Allan H. Young</name></author><author><name sortKey="Kotzalidis, Georgios D" sort="Kotzalidis, Georgios D" uniqKey="Kotzalidis G" first="Georgios D." last="Kotzalidis">Georgios D. Kotzalidis</name></author><author><name sortKey="Macqueen, Glenda M" sort="Macqueen, Glenda M" uniqKey="Macqueen G" first="Glenda M." last="Macqueen">Glenda M. Macqueen</name></author><author><name sortKey="Bowden, Charles L" sort="Bowden, Charles L" uniqKey="Bowden C" first="Charles L." last="Bowden">Charles L. Bowden</name></author><author><name sortKey="Ghaemi, S Nassir" sort="Ghaemi, S Nassir" uniqKey="Ghaemi S" first="S. Nassir" last="Ghaemi">S. Nassir Ghaemi</name></author><author><name sortKey="Lopez Jaramillo, Carlos" sort="Lopez Jaramillo, Carlos" uniqKey="Lopez Jaramillo C" first="Carlos" last="Lopez-Jaramillo">Carlos Lopez-Jaramillo</name></author><author><name sortKey="Rybakowski, Janusz" sort="Rybakowski, Janusz" uniqKey="Rybakowski J" first="Janusz" last="Rybakowski">Janusz Rybakowski</name></author><author><name sortKey="Ha, Kyooseob" sort="Ha, Kyooseob" uniqKey="Ha K" first="Kyooseob" last="Ha">Kyooseob Ha</name></author><author><name sortKey="Perugi, Giulio" sort="Perugi, Giulio" uniqKey="Perugi G" first="Giulio" last="Perugi">Giulio Perugi</name></author><author><name sortKey="Kasper, Siegfried" sort="Kasper, Siegfried" uniqKey="Kasper S" first="Siegfried" last="Kasper">Siegfried Kasper</name></author><author><name sortKey="Amsterdam, Jay D" sort="Amsterdam, Jay D" uniqKey="Amsterdam J" first="Jay D." last="Amsterdam">Jay D. Amsterdam</name></author><author><name sortKey="Hirschfeld, Robert M" sort="Hirschfeld, Robert M" uniqKey="Hirschfeld R" first="Robert M." last="Hirschfeld">Robert M. Hirschfeld</name></author><author><name sortKey="Kapczinski, Flavio" sort="Kapczinski, Flavio" uniqKey="Kapczinski F" first="Flávio" last="Kapczinski">Flávio Kapczinski</name></author><author><name sortKey="Vieta, Eduard" sort="Vieta, Eduard" uniqKey="Vieta E" first="Eduard" last="Vieta">Eduard Vieta</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24030475</idno><idno type="pmc">4091043</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091043</idno><idno type="RBID">PMC:4091043</idno><idno type="doi">10.1176/appi.ajp.2013.13020185</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001C88</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C88</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The International Society for Bipolar Disorders (ISBD) Task Force Report on Antidepressant Use in Bipolar Disorders</title><author><name sortKey="Pacchiarotti, Isabella" sort="Pacchiarotti, Isabella" uniqKey="Pacchiarotti I" first="Isabella" last="Pacchiarotti">Isabella Pacchiarotti</name></author><author><name sortKey="Bond, David J" sort="Bond, David J" uniqKey="Bond D" first="David J." last="Bond">David J. Bond</name></author><author><name sortKey="Baldessarini, Ross J" sort="Baldessarini, Ross J" uniqKey="Baldessarini R" first="Ross J." last="Baldessarini">Ross J. Baldessarini</name></author><author><name sortKey="Nolen, Willem A" sort="Nolen, Willem A" uniqKey="Nolen W" first="Willem A." last="Nolen">Willem A. Nolen</name></author><author><name sortKey="Grunze, Heinz" sort="Grunze, Heinz" uniqKey="Grunze H" first="Heinz" last="Grunze">Heinz Grunze</name></author><author><name sortKey="Licht, Rasmus W" sort="Licht, Rasmus W" uniqKey="Licht R" first="Rasmus W." last="Licht">Rasmus W. Licht</name></author><author><name sortKey="Post, Robert M" sort="Post, Robert M" uniqKey="Post R" first="Robert M." last="Post">Robert M. Post</name></author><author><name sortKey="Berk, Michael" sort="Berk, Michael" uniqKey="Berk M" first="Michael" last="Berk">Michael Berk</name></author><author><name sortKey="Goodwin, Guy M" sort="Goodwin, Guy M" uniqKey="Goodwin G" first="Guy M." last="Goodwin">Guy M. Goodwin</name></author><author><name sortKey="Sachs, Gary S" sort="Sachs, Gary S" uniqKey="Sachs G" first="Gary S." last="Sachs">Gary S. Sachs</name></author><author><name sortKey="Tondo, Leonardo" sort="Tondo, Leonardo" uniqKey="Tondo L" first="Leonardo" last="Tondo">Leonardo Tondo</name></author><author><name sortKey="Findling, Robert L" sort="Findling, Robert L" uniqKey="Findling R" first="Robert L." last="Findling">Robert L. Findling</name></author><author><name sortKey="Youngstrom, Eric A" sort="Youngstrom, Eric A" uniqKey="Youngstrom E" first="Eric A." last="Youngstrom">Eric A. Youngstrom</name></author><author><name sortKey="Tohen, Mauricio" sort="Tohen, Mauricio" uniqKey="Tohen M" first="Mauricio" last="Tohen">Mauricio Tohen</name></author><author><name sortKey="Undurraga, Juan" sort="Undurraga, Juan" uniqKey="Undurraga J" first="Juan" last="Undurraga">Juan Undurraga</name></author><author><name sortKey="Gonzalez Pinto, Ana" sort="Gonzalez Pinto, Ana" uniqKey="Gonzalez Pinto A" first="Ana" last="González-Pinto">Ana González-Pinto</name></author><author><name sortKey="Goldberg, Joseph F" sort="Goldberg, Joseph F" uniqKey="Goldberg J" first="Joseph F." last="Goldberg">Joseph F. Goldberg</name></author><author><name sortKey="Yildiz, Ay Egul" sort="Yildiz, Ay Egul" uniqKey="Yildiz A" first="Ay Egül" last="Yildiz">Ay Egül Yildiz</name></author><author><name sortKey="Altshuler, Lori L" sort="Altshuler, Lori L" uniqKey="Altshuler L" first="Lori L." last="Altshuler">Lori L. Altshuler</name></author><author><name sortKey="Calabrese, Joseph R" sort="Calabrese, Joseph R" uniqKey="Calabrese J" first="Joseph R." last="Calabrese">Joseph R. Calabrese</name></author><author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B." last="Mitchell">Philip B. Mitchell</name></author><author><name sortKey="Thase, Michael E" sort="Thase, Michael E" uniqKey="Thase M" first="Michael E." last="Thase">Michael E. Thase</name></author><author><name sortKey="Koukopoulos, Athanasios" sort="Koukopoulos, Athanasios" uniqKey="Koukopoulos A" first="Athanasios" last="Koukopoulos">Athanasios Koukopoulos</name></author><author><name sortKey="Colom, Francesc" sort="Colom, Francesc" uniqKey="Colom F" first="Francesc" last="Colom">Francesc Colom</name></author><author><name sortKey="Frye, Mark A" sort="Frye, Mark A" uniqKey="Frye M" first="Mark A." last="Frye">Mark A. Frye</name></author><author><name sortKey="Malhi, Gin S" sort="Malhi, Gin S" uniqKey="Malhi G" first="Gin S." last="Malhi">Gin S. Malhi</name></author><author><name sortKey="Fountoulakis, Konstantinos N" sort="Fountoulakis, Konstantinos N" uniqKey="Fountoulakis K" first="Konstantinos N." last="Fountoulakis">Konstantinos N. Fountoulakis</name></author><author><name sortKey="Vazquez, Gustavo" sort="Vazquez, Gustavo" uniqKey="Vazquez G" first="Gustavo" last="Vázquez">Gustavo Vázquez</name></author><author><name sortKey="Perlis, Roy H" sort="Perlis, Roy H" uniqKey="Perlis R" first="Roy H." last="Perlis">Roy H. Perlis</name></author><author><name sortKey="Ketter, Terence A" sort="Ketter, Terence A" uniqKey="Ketter T" first="Terence A." last="Ketter">Terence A. Ketter</name></author><author><name sortKey="Cassidy, Frederick" sort="Cassidy, Frederick" uniqKey="Cassidy F" first="Frederick" last="Cassidy">Frederick Cassidy</name></author><author><name sortKey="Akiskal, Hagop" sort="Akiskal, Hagop" uniqKey="Akiskal H" first="Hagop" last="Akiskal">Hagop Akiskal</name></author><author><name sortKey="Azorin, Jean Michel" sort="Azorin, Jean Michel" uniqKey="Azorin J" first="Jean-Michel" last="Azorin">Jean-Michel Azorin</name></author><author><name sortKey="Valenti, Marc" sort="Valenti, Marc" uniqKey="Valenti M" first="Marc" last="Valentí">Marc Valentí</name></author><author><name sortKey="Mazzei, Diego Hidalgo" sort="Mazzei, Diego Hidalgo" uniqKey="Mazzei D" first="Diego Hidalgo" last="Mazzei">Diego Hidalgo Mazzei</name></author><author><name sortKey="Lafer, Beny" sort="Lafer, Beny" uniqKey="Lafer B" first="Beny" last="Lafer">Beny Lafer</name></author><author><name sortKey="Kato, Tadafumi" sort="Kato, Tadafumi" uniqKey="Kato T" first="Tadafumi" last="Kato">Tadafumi Kato</name></author><author><name sortKey="Mazzarini, Lorenzo" sort="Mazzarini, Lorenzo" uniqKey="Mazzarini L" first="Lorenzo" last="Mazzarini">Lorenzo Mazzarini</name></author><author><name sortKey="Martinez Aran, Anabel" sort="Martinez Aran, Anabel" uniqKey="Martinez Aran A" first="Anabel" last="Martínez-Aran">Anabel Martínez-Aran</name></author><author><name sortKey="Parker, Gordon" sort="Parker, Gordon" uniqKey="Parker G" first="Gordon" last="Parker">Gordon Parker</name></author><author><name sortKey="Souery, Daniel" sort="Souery, Daniel" uniqKey="Souery D" first="Daniel" last="Souery">Daniel Souery</name></author><author><name sortKey="Ozerdem, Ay Egul" sort="Ozerdem, Ay Egul" uniqKey="Ozerdem A" first="Ay Egül" last="Özerdem">Ay Egül Özerdem</name></author><author><name sortKey="Mcelroy, Susan L" sort="Mcelroy, Susan L" uniqKey="Mcelroy S" first="Susan L." last="Mcelroy">Susan L. Mcelroy</name></author><author><name sortKey="Girardi, Paolo" sort="Girardi, Paolo" uniqKey="Girardi P" first="Paolo" last="Girardi">Paolo Girardi</name></author><author><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name></author><author><name sortKey="Yatham, Lakshmi N" sort="Yatham, Lakshmi N" uniqKey="Yatham L" first="Lakshmi N." last="Yatham">Lakshmi N. Yatham</name></author><author><name sortKey="Zarate, Carlos A" sort="Zarate, Carlos A" uniqKey="Zarate C" first="Carlos A." last="Zarate">Carlos A. Zarate</name></author><author><name sortKey="Nierenberg, Andrew A" sort="Nierenberg, Andrew A" uniqKey="Nierenberg A" first="Andrew A." last="Nierenberg">Andrew A. Nierenberg</name></author><author><name sortKey="Birmaher, Boris" sort="Birmaher, Boris" uniqKey="Birmaher B" first="Boris" last="Birmaher">Boris Birmaher</name></author><author><name sortKey="Kanba, Shigenobu" sort="Kanba, Shigenobu" uniqKey="Kanba S" first="Shigenobu" last="Kanba">Shigenobu Kanba</name></author><author><name sortKey="El Mallakh, Rif S" sort="El Mallakh, Rif S" uniqKey="El Mallakh R" first="Rif S." last="El-Mallakh">Rif S. El-Mallakh</name></author><author><name sortKey="Serretti, Alessandro" sort="Serretti, Alessandro" uniqKey="Serretti A" first="Alessandro" last="Serretti">Alessandro Serretti</name></author><author><name sortKey="Rihmer, Zoltan" sort="Rihmer, Zoltan" uniqKey="Rihmer Z" first="Zoltan" last="Rihmer">Zoltan Rihmer</name></author><author><name sortKey="Young, Allan H" sort="Young, Allan H" uniqKey="Young A" first="Allan H." last="Young">Allan H. Young</name></author><author><name sortKey="Kotzalidis, Georgios D" sort="Kotzalidis, Georgios D" uniqKey="Kotzalidis G" first="Georgios D." last="Kotzalidis">Georgios D. Kotzalidis</name></author><author><name sortKey="Macqueen, Glenda M" sort="Macqueen, Glenda M" uniqKey="Macqueen G" first="Glenda M." last="Macqueen">Glenda M. Macqueen</name></author><author><name sortKey="Bowden, Charles L" sort="Bowden, Charles L" uniqKey="Bowden C" first="Charles L." last="Bowden">Charles L. Bowden</name></author><author><name sortKey="Ghaemi, S Nassir" sort="Ghaemi, S Nassir" uniqKey="Ghaemi S" first="S. Nassir" last="Ghaemi">S. Nassir Ghaemi</name></author><author><name sortKey="Lopez Jaramillo, Carlos" sort="Lopez Jaramillo, Carlos" uniqKey="Lopez Jaramillo C" first="Carlos" last="Lopez-Jaramillo">Carlos Lopez-Jaramillo</name></author><author><name sortKey="Rybakowski, Janusz" sort="Rybakowski, Janusz" uniqKey="Rybakowski J" first="Janusz" last="Rybakowski">Janusz Rybakowski</name></author><author><name sortKey="Ha, Kyooseob" sort="Ha, Kyooseob" uniqKey="Ha K" first="Kyooseob" last="Ha">Kyooseob Ha</name></author><author><name sortKey="Perugi, Giulio" sort="Perugi, Giulio" uniqKey="Perugi G" first="Giulio" last="Perugi">Giulio Perugi</name></author><author><name sortKey="Kasper, Siegfried" sort="Kasper, Siegfried" uniqKey="Kasper S" first="Siegfried" last="Kasper">Siegfried Kasper</name></author><author><name sortKey="Amsterdam, Jay D" sort="Amsterdam, Jay D" uniqKey="Amsterdam J" first="Jay D." last="Amsterdam">Jay D. Amsterdam</name></author><author><name sortKey="Hirschfeld, Robert M" sort="Hirschfeld, Robert M" uniqKey="Hirschfeld R" first="Robert M." last="Hirschfeld">Robert M. Hirschfeld</name></author><author><name sortKey="Kapczinski, Flavio" sort="Kapczinski, Flavio" uniqKey="Kapczinski F" first="Flávio" last="Kapczinski">Flávio Kapczinski</name></author><author><name sortKey="Vieta, Eduard" sort="Vieta, Eduard" uniqKey="Vieta E" first="Eduard" last="Vieta">Eduard Vieta</name></author></analytic><series><title level="j">The American journal of psychiatry</title><idno type="ISSN">0002-953X</idno><idno type="eISSN">1535-7228</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P2">The risk-benefit profile of antidepressant medications in bipolar disorder is controversial. When conclusive evidence is lacking, expert consensus can guide treatment decisions. The International Society for Bipolar Disorders (ISBD) convened a task force to seek consensus recommendations on the use of antidepressants in bipolar disorders.</p></sec><sec id="S2"><title>Method</title><p id="P3">An expert task force iteratively developed consensus through serial consensus-based revisions using the Delphi method. Initial survey items were based on systematic review of the literature. Subsequent surveys included new or reworded items and items that needed to be rerated. This process resulted in the final ISBD Task Force clinical recommendations on antidepressant use in bipolar disorder.</p></sec><sec id="S3"><title>Results</title><p id="P4">There is striking incongruity between the wide use of and the weak evidence base for the efficacy and safety of antidepressant drugs in bipolar disorder. Few well-designed, long-term trials of prophylactic benefits have been conducted, and there is insufficient evidence for treatment benefits with antidepressants combined with mood stabilizers. A major concern is the risk for mood switch to hypomania, mania, and mixed states. Integrating the evidence and the experience of the task force members, a consensus was reached on 12 statements on the use of antidepressants in bipolar disorder.</p></sec><sec id="S4"><title>Conclusions</title><p id="P5">Because of limited data, the task force could not make broad statements endorsing antidepressant use but acknowledged that individual bipolar patients may benefit from antidepressants. Regarding safety, serotonin reuptake inhibitors and bupropion may have lower rates of manic switch than tricyclic and tetracyclic antidepressants and norepinephrine-serotonin reuptake inhibitors. The frequency and severity of antidepressant-associated mood elevations appear to be greater in bipolar I than bipolar II disorder. Hence, in bipolar I patients antidepressants should be prescribed only as an adjunct to mood-stabilizing medications.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0370512</journal-id><journal-id journal-id-type="pubmed-jr-id">457</journal-id><journal-id journal-id-type="nlm-ta">Am J Psychiatry</journal-id><journal-id journal-id-type="iso-abbrev">Am J Psychiatry</journal-id><journal-title-group><journal-title>The American journal of psychiatry</journal-title></journal-title-group><issn pub-type="ppub">0002-953X</issn><issn pub-type="epub">1535-7228</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24030475</article-id><article-id pub-id-type="pmc">4091043</article-id><article-id pub-id-type="doi">10.1176/appi.ajp.2013.13020185</article-id><article-id pub-id-type="manuscript">NIHMS596538</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The International Society for Bipolar Disorders (ISBD) Task Force Report on Antidepressant Use in Bipolar Disorders</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Pacchiarotti</surname><given-names>Isabella</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Bond</surname><given-names>David J.</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Baldessarini</surname><given-names>Ross J.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Nolen</surname><given-names>Willem A.</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Grunze</surname><given-names>Heinz</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Licht</surname><given-names>Rasmus W.</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Post</surname><given-names>Robert M.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Berk</surname><given-names>Michael</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Goodwin</surname><given-names>Guy M.</given-names></name><degrees>F.Med.Sci.</degrees></contrib><contrib contrib-type="author"><name><surname>Sachs</surname><given-names>Gary S.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Tondo</surname><given-names>Leonardo</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Findling</surname><given-names>Robert L.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Youngstrom</surname><given-names>Eric A.</given-names></name><degrees>Psy.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Tohen</surname><given-names>Mauricio</given-names></name><degrees>M.D., Dr.P.H.</degrees></contrib><contrib contrib-type="author"><name><surname>Undurraga</surname><given-names>Juan</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>González-Pinto</surname><given-names>Ana</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Goldberg</surname><given-names>Joseph F.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Yildiz</surname><given-names>Ayşegül</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Altshuler</surname><given-names>Lori L.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Calabrese</surname><given-names>Joseph R.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Mitchell</surname><given-names>Philip B.</given-names></name><degrees>M.B.B.S., M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Thase</surname><given-names>Michael E.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Koukopoulos</surname><given-names>Athanasios</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Colom</surname><given-names>Francesc</given-names></name><degrees>Psy.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Frye</surname><given-names>Mark A.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Malhi</surname><given-names>Gin S.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Fountoulakis</surname><given-names>Konstantinos N.</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Vázquez</surname><given-names>Gustavo</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Perlis</surname><given-names>Roy H.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Ketter</surname><given-names>Terence A.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Cassidy</surname><given-names>Frederick</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Akiskal</surname><given-names>Hagop</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Azorin</surname><given-names>Jean-Michel</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Valentí</surname><given-names>Marc</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Mazzei</surname><given-names>Diego Hidalgo</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Lafer</surname><given-names>Beny</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Kato</surname><given-names>Tadafumi</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Mazzarini</surname><given-names>Lorenzo</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Martínez-Aran</surname><given-names>Anabel</given-names></name><degrees>Psy.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Parker</surname><given-names>Gordon</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Souery</surname><given-names>Daniel</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Özerdem</surname><given-names>Ayşegül</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>McElroy</surname><given-names>Susan L.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Girardi</surname><given-names>Paolo</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Bauer</surname><given-names>Michael</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Yatham</surname><given-names>Lakshmi N.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Zarate</surname><given-names>Carlos A.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Nierenberg</surname><given-names>Andrew A.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Birmaher</surname><given-names>Boris</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Kanba</surname><given-names>Shigenobu</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>El-Mallakh</surname><given-names>Rif S.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Serretti</surname><given-names>Alessandro</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Rihmer</surname><given-names>Zoltan</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Young</surname><given-names>Allan H.</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Kotzalidis</surname><given-names>Georgios D.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>MacQueen</surname><given-names>Glenda M.</given-names></name><degrees>M.D., Ph.D.N.</degrees></contrib><contrib contrib-type="author"><name><surname>Bowden</surname><given-names>Charles L.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Ghaemi</surname><given-names>S. Nassir</given-names></name><degrees>M.D., M.P.H.</degrees></contrib><contrib contrib-type="author"><name><surname>Lopez-Jaramillo</surname><given-names>Carlos</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Rybakowski</surname><given-names>Janusz</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Ha</surname><given-names>Kyooseob</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Perugi</surname><given-names>Giulio</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Kasper</surname><given-names>Siegfried</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Amsterdam</surname><given-names>Jay D.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Hirschfeld</surname><given-names>Robert M.</given-names></name><degrees>M.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Kapczinski</surname><given-names>Flávio</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><contrib contrib-type="author"><name><surname>Vieta</surname><given-names>Eduard</given-names></name><degrees>M.D., Ph.D.</degrees></contrib><aff id="A1">Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clinic Barcelona, IDIBAPS (Institute of Biomedical Research August Pi i Sunyer), CIBERSAM (Center for Biomedical Research Network on Mental Health), University of Barcelona, Barcelona, Spain; Mood Disorders Centre, Department of Psychiatry, University of British Columbia, Vancouver; Department of Psychiatry, Harvard Medical School, Boston; Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, U.K.; Mood Disorders Research Unit, Aarhus University Hospital, Risskov, Denmark; Bipolar Collaborative Network, Bethesda, Md.; School of Medicine, Deakin University, Geelong, Australia; University Department of Psychiatry, Warneford Hospital, Oxford, U.K.; Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston; Department of Psychiatry, Harvard Medical School, Boston; Lucio Bini Mood Disorder Center, Cagliari, Italy; Division of Child and Adolescent Psychiatry, Case Western Reserve University School of Medicine, Cleveland; Johns Hopkins Children’s Center, Baltimore; Department of Psychology, University of North Carolina, Chapel Hill; Department of Psychiatry, School of Medicine, University of New Mexico, Albuquerque; Department of Psychiatry, Santiago Apóstol Hospital, University of the Basque Country, CIBERSAM, Vitoria, Spain; Department of Psychiatry, Mount Sinai School of Medicine, New York; Department of Psychiatry and Department of Neurosciences, Dokuz Eylül Üniversitesi, Izmir, Turkey; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles; University of New South Wales School of Psychiatry and Black Dog Institute, Prince of Wales Hospital, Randwick, New South Wales, Australia; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia; Philadelphia Veterans Affairs Medical Center, Philadelphia; Centro Lucio Bini, Rome; Departments of Psychiatry and Psychology, Integrated Mood Group, Mayo Clinic, Rochester, Minn.; CADE Clinic, Discipline of Psychiatry, University of Sydney, Sydney, Australia; 3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece; Department of Neuroscience, Palermo University, Buenos Aires, Argentina; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford; Duke University Medical Center, Durham, N.C.; International Mood Center, University of California at San Diego, La Jolla, Calif.; Hôpital Sainte Marguerite, Marseille, France; Bipolar Research Program, Department and Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan; Sapienza University–Rome, School of Medicine and Psychology, NESMOS Department, Sant’Andrea Hospital, Rome; Laboratory of Medical Psychology, Free University of Brussels and “Psy Pluriel,” European Center for Medical Psychology, Brussels; University of Cincinnati College of Medicine, Psychiatry and Behavioral Neuroscience, Cincinnati; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; NIMH, Bethesda, Md.; Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh; Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; University of Louisville, Louisville, Ky.; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy; Department of Clinical and Theoretical Mental Health, Semmelweis University, Budapest, Hungary; Imperial College, London; Department of Psychiatry, University Calgary, Calgary, Canada; Department of Psychiatry, University of Texas Health Science Center at San Antonio; Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Tufts University School of Medicine, Boston; Mood Disorders Program, Fundacion San Vicente de Paul, Department of Psychiatry, Universidad de Antioquia, Medellín, Colombia; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland; Mood Disorders Clinic and Clinical Affective Neuroscience Laboratory, Department of Psychiatry, Seoul National University Bundang Hospital, Bundang, Republic of Korea; Department of Psychiatry, University of Pisa, Pisa, Italy; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna; Depression Research Unit, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia; Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston; and Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.</aff></contrib-group><author-notes><corresp id="cor1">Address correspondence to Dr. Vieta (<email>evieta@clinic.ub.es</email>)</corresp><fn id="FN1"><p id="P1">Dr. Koukopoulos died in April 2013.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>4</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>11</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>11</month><year>2014</year></pub-date><volume>170</volume><issue>11</issue><fpage>1249</fpage><lpage>1262</lpage><pmc-comment>elocation-id from pubmed: 10.1176/appi.ajp.2013.13020185</pmc-comment>
<abstract><sec id="S1"><title>Objective</title><p id="P2">The risk-benefit profile of antidepressant medications in bipolar disorder is controversial. When conclusive evidence is lacking, expert consensus can guide treatment decisions. The International Society for Bipolar Disorders (ISBD) convened a task force to seek consensus recommendations on the use of antidepressants in bipolar disorders.</p></sec><sec id="S2"><title>Method</title><p id="P3">An expert task force iteratively developed consensus through serial consensus-based revisions using the Delphi method. Initial survey items were based on systematic review of the literature. Subsequent surveys included new or reworded items and items that needed to be rerated. This process resulted in the final ISBD Task Force clinical recommendations on antidepressant use in bipolar disorder.</p></sec><sec id="S3"><title>Results</title><p id="P4">There is striking incongruity between the wide use of and the weak evidence base for the efficacy and safety of antidepressant drugs in bipolar disorder. Few well-designed, long-term trials of prophylactic benefits have been conducted, and there is insufficient evidence for treatment benefits with antidepressants combined with mood stabilizers. A major concern is the risk for mood switch to hypomania, mania, and mixed states. Integrating the evidence and the experience of the task force members, a consensus was reached on 12 statements on the use of antidepressants in bipolar disorder.</p></sec><sec id="S4"><title>Conclusions</title><p id="P5">Because of limited data, the task force could not make broad statements endorsing antidepressant use but acknowledged that individual bipolar patients may benefit from antidepressants. Regarding safety, serotonin reuptake inhibitors and bupropion may have lower rates of manic switch than tricyclic and tetracyclic antidepressants and norepinephrine-serotonin reuptake inhibitors. The frequency and severity of antidepressant-associated mood elevations appear to be greater in bipolar I than bipolar II disorder. Hence, in bipolar I patients antidepressants should be prescribed only as an adjunct to mood-stabilizing medications.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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