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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide association analysis of young onset stroke identifies a locus on chromosome 10q25 near <italic>HABP2</italic>
</title>
<author><name sortKey="Cheng, Yu Ching" sort="Cheng, Yu Ching" uniqKey="Cheng Y" first="Yu-Ching" last="Cheng">Yu-Ching Cheng</name>
<affiliation><nlm:aff id="A1">Veterans Affairs Maryland Health Care System, Baltimore, Maryland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of Maryland School of Medicine, Baltimore, Maryland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stanne, Tara M" sort="Stanne, Tara M" uniqKey="Stanne T" first="Tara M." last="Stanne">Tara M. Stanne</name>
<affiliation><nlm:aff id="A3">The University of Gothenburg, Gothenburg, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giese, Anne Katrin" sort="Giese, Anne Katrin" uniqKey="Giese A" first="Anne-Katrin" last="Giese">Anne-Katrin Giese</name>
<affiliation><nlm:aff id="A4">University of Rostock, Rostock, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ho, Weang Kee" sort="Ho, Weang Kee" uniqKey="Ho W" first="Weang Kee" last="Ho">Weang Kee Ho</name>
<affiliation><nlm:aff id="A5">University of Nottingham Malaysia Campus, Selangor Darul Ehsa, Malaysia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Traylor, Matthew" sort="Traylor, Matthew" uniqKey="Traylor M" first="Matthew" last="Traylor">Matthew Traylor</name>
<affiliation><nlm:aff id="A6">University of Cambridge, Cambridge, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<affiliation><nlm:aff id="A7">Institut Pasteur de Lille, F-59000 Lille, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name>
<affiliation><nlm:aff id="A8">University of Newcastle, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Malik, Rainer" sort="Malik, Rainer" uniqKey="Malik R" first="Rainer" last="Malik">Rainer Malik</name>
<affiliation><nlm:aff id="A9">Ludwig-Maximilians-Universität München, Munich, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Xu, Huichun" sort="Xu, Huichun" uniqKey="Xu H" first="Huichun" last="Xu">Huichun Xu</name>
<affiliation><nlm:aff id="A2">University of Maryland School of Medicine, Baltimore, Maryland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kittner, Steven J" sort="Kittner, Steven J" uniqKey="Kittner S" first="Steven J." last="Kittner">Steven J. Kittner</name>
<affiliation><nlm:aff id="A1">Veterans Affairs Maryland Health Care System, Baltimore, Maryland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of Maryland School of Medicine, Baltimore, Maryland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cole, John W" sort="Cole, John W" uniqKey="Cole J" first="John W." last="Cole">John W. Cole</name>
<affiliation><nlm:aff id="A1">Veterans Affairs Maryland Health Care System, Baltimore, Maryland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of Maryland School of Medicine, Baltimore, Maryland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="O Onnell, Jeffrey R" sort="O Onnell, Jeffrey R" uniqKey="O Onnell J" first="Jeffrey R." last="O Onnell">Jeffrey R. O Onnell</name>
<affiliation><nlm:aff id="A2">University of Maryland School of Medicine, Baltimore, Maryland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name>
<affiliation><nlm:aff id="A6">University of Cambridge, Cambridge, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Cambridge, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rasheed, Asif" sort="Rasheed, Asif" uniqKey="Rasheed A" first="Asif" last="Rasheed">Asif Rasheed</name>
<affiliation><nlm:aff id="A11">Center for Non-communicable Diseases, Karachi, Pakistan</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhao, Wei" sort="Zhao, Wei" uniqKey="Zhao W" first="Wei" last="Zhao">Wei Zhao</name>
<affiliation><nlm:aff id="A12">University of Pennsylvania, US</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Engelter, Stefan" sort="Engelter, Stefan" uniqKey="Engelter S" first="Stefan" last="Engelter">Stefan Engelter</name>
<affiliation><nlm:aff id="A13">Basel University Hospital, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Grond Ginsbach, Caspar" sort="Grond Ginsbach, Caspar" uniqKey="Grond Ginsbach C" first="Caspar" last="Grond-Ginsbach">Caspar Grond-Ginsbach</name>
<affiliation><nlm:aff id="A14">Heidelberg University Hospital, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kamatani, Yoichiro" sort="Kamatani, Yoichiro" uniqKey="Kamatani Y" first="Yoichiro" last="Kamatani">Yoichiro Kamatani</name>
<affiliation><nlm:aff id="A15">Centre d’Étude du Polymorphisme Humain, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A16">RIKEN Center for Integrative Medical Sciences, Yokohama, Japan</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<affiliation><nlm:aff id="A17">National Genotyping Center, Evry, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A18">Genome Quebec, McGill University, Montreal, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Leys, Didier" sort="Leys, Didier" uniqKey="Leys D" first="Didier" last="Leys">Didier Leys</name>
<affiliation><nlm:aff id="A19">Lille University Hospital, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Thijs, Vincent" sort="Thijs, Vincent" uniqKey="Thijs V" first="Vincent" last="Thijs">Vincent Thijs</name>
<affiliation><nlm:aff id="A20">KU Leuven - University of Leuven, B-3000 Leuven, Belgium</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A21">Vesalius Research Center, VIB, B-3000 Leuven, Belgium</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A22">University Hospitals Leuven, B-3000 Leuven, Belgium</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Metso, Tiina M" sort="Metso, Tiina M" uniqKey="Metso T" first="Tiina M." last="Metso">Tiina M. Metso</name>
<affiliation><nlm:aff id="A23">Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tatlisumak, Turgut" sort="Tatlisumak, Turgut" uniqKey="Tatlisumak T" first="Turgut" last="Tatlisumak">Turgut Tatlisumak</name>
<affiliation><nlm:aff id="A23">Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pezzini, Alessandro" sort="Pezzini, Alessandro" uniqKey="Pezzini A" first="Alessandro" last="Pezzini">Alessandro Pezzini</name>
<affiliation><nlm:aff id="A24">Università degli Studi di Brescia, Brescia, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Parati, Eugenio A" sort="Parati, Eugenio A" uniqKey="Parati E" first="Eugenio A." last="Parati">Eugenio A. Parati</name>
<affiliation><nlm:aff id="A25">Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Norrving, Bo" sort="Norrving, Bo" uniqKey="Norrving B" first="Bo" last="Norrving">Bo Norrving</name>
<affiliation><nlm:aff id="A26">University of Lund, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bevan, Steve" sort="Bevan, Steve" uniqKey="Bevan S" first="Steve" last="Bevan">Steve Bevan</name>
<affiliation><nlm:aff id="A6">University of Cambridge, Cambridge, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rothwell, Peter M" sort="Rothwell, Peter M" uniqKey="Rothwell P" first="Peter M" last="Rothwell">Peter M. Rothwell</name>
<affiliation><nlm:aff id="A27">University of Oxford, John Radcliffe Hospital</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sudlow, Cathie" sort="Sudlow, Cathie" uniqKey="Sudlow C" first="Cathie" last="Sudlow">Cathie Sudlow</name>
<affiliation><nlm:aff id="A28">University of Edinburgh, Edinburgh, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Slowik, Agnieszka" sort="Slowik, Agnieszka" uniqKey="Slowik A" first="Agnieszka" last="Slowik">Agnieszka Slowik</name>
<affiliation><nlm:aff id="A29">Jagiellonian University Medical College, Krakow, Poland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lindgren, Arne" sort="Lindgren, Arne" uniqKey="Lindgren A" first="Arne" last="Lindgren">Arne Lindgren</name>
<affiliation><nlm:aff id="A30">Lund University, Lund, Sweden</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A31">Skåne University Hospital, Lund, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Walters, Matthew R" sort="Walters, Matthew R" uniqKey="Walters M" first="Matthew R" last="Walters">Matthew R. Walters</name>
<affiliation><nlm:aff id="A32">University of Glasgow, Glasgow, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jannes, Jim" sort="Jannes, Jim" uniqKey="Jannes J" first="Jim" last="Jannes">Jim Jannes</name>
<affiliation><nlm:aff id="A33">University of Adelaide, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shen, Jess" sort="Shen, Jess" uniqKey="Shen J" first="Jess" last="Shen">Jess Shen</name>
<affiliation><nlm:aff id="A34">Mount Sinai Hospital, Toronto, Ontario</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Crosslin, David" sort="Crosslin, David" uniqKey="Crosslin D" first="David" last="Crosslin">David Crosslin</name>
<affiliation><nlm:aff id="A35">University of Washington, Seattle, Washington</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Doheny, Kimberly" sort="Doheny, Kimberly" uniqKey="Doheny K" first="Kimberly" last="Doheny">Kimberly Doheny</name>
<affiliation><nlm:aff id="A36">Johns Hopkins University School of Medicine, Baltimore, Maryland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Laurie, Cathy C" sort="Laurie, Cathy C" uniqKey="Laurie C" first="Cathy C." last="Laurie">Cathy C. Laurie</name>
<affiliation><nlm:aff id="A35">University of Washington, Seattle, Washington</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kanse, Sandip M" sort="Kanse, Sandip M" uniqKey="Kanse S" first="Sandip M." last="Kanse">Sandip M. Kanse</name>
<affiliation><nlm:aff id="A37">University of Oslo, Oslo, Norway</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation><nlm:aff id="A35">University of Washington, Seattle, Washington</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation><nlm:aff id="A38">The University of Texas Health Science Center at Houston, Houston, Texas</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name>
<affiliation><nlm:aff id="A39">University of Mississippi Medical Center, Jackson, MS</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hopewell, Jemma C" sort="Hopewell, Jemma C" uniqKey="Hopewell J" first="Jemma C." last="Hopewell">Jemma C. Hopewell</name>
<affiliation><nlm:aff id="A40">University of Oxford, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Strauch, Konstantin" sort="Strauch, Konstantin" uniqKey="Strauch K" first="Konstantin" last="Strauch">Konstantin Strauch</name>
<affiliation><nlm:aff id="A9">Ludwig-Maximilians-Universität München, Munich, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A41">Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name>
<affiliation><nlm:aff id="A9">Ludwig-Maximilians-Universität München, Munich, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A41">Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A42">Partner site Munich Heart Alliance, Munich, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A50">University Hospital Grosshadern, Munich, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name>
<affiliation><nlm:aff id="A41">Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name>
<affiliation><nlm:aff id="A41">Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name>
<affiliation><nlm:aff id="A41">Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A42">Partner site Munich Heart Alliance, Munich, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meisinger, Christine" sort="Meisinger, Christine" uniqKey="Meisinger C" first="Christine" last="Meisinger">Christine Meisinger</name>
<affiliation><nlm:aff id="A41">Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name>
<affiliation><nlm:aff id="A43">Erasmus University Medical Center Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Longstreth, Wt" sort="Longstreth, Wt" uniqKey="Longstreth W" first="Wt" last="Longstreth">Wt Longstreth</name>
<affiliation><nlm:aff id="A35">University of Washington, Seattle, Washington</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meschia, James F" sort="Meschia, James F" uniqKey="Meschia J" first="James F." last="Meschia">James F. Meschia</name>
<affiliation><nlm:aff id="A44">Mayo Clinic, Florida</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<affiliation><nlm:aff id="A45">Boston University School of Medicine, Boston, MA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name>
<affiliation><nlm:aff id="A46">Royal Holloway, University of London, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Worrall, Bradford" sort="Worrall, Bradford" uniqKey="Worrall B" first="Bradford" last="Worrall">Bradford Worrall</name>
<affiliation><nlm:aff id="A47">University of Virginia, Charlottesville, Virginia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jern, Christina" sort="Jern, Christina" uniqKey="Jern C" first="Christina" last="Jern">Christina Jern</name>
<affiliation><nlm:aff id="A3">The University of Gothenburg, Gothenburg, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Levi, Christopher" sort="Levi, Christopher" uniqKey="Levi C" first="Christopher" last="Levi">Christopher Levi</name>
<affiliation><nlm:aff id="A48">John Hunter Hospital, Newcastle, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name>
<affiliation><nlm:aff id="A9">Ludwig-Maximilians-Universität München, Munich, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Boncoraglio, Giorgio B" sort="Boncoraglio, Giorgio B" uniqKey="Boncoraglio G" first="Giorgio B." last="Boncoraglio">Giorgio B. Boncoraglio</name>
<affiliation><nlm:aff id="A25">Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Markus, Hugh S" sort="Markus, Hugh S" uniqKey="Markus H" first="Hugh S." last="Markus">Hugh S. Markus</name>
<affiliation><nlm:aff id="A6">University of Cambridge, Cambridge, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<affiliation><nlm:aff id="A6">University of Cambridge, Cambridge, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A19">Lille University Hospital, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A49">University Hospital of Bordeaux, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rolfs, Arndt" sort="Rolfs, Arndt" uniqKey="Rolfs A" first="Arndt" last="Rolfs">Arndt Rolfs</name>
<affiliation><nlm:aff id="A4">University of Rostock, Rostock, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Saleheen, Danish" sort="Saleheen, Danish" uniqKey="Saleheen D" first="Danish" last="Saleheen">Danish Saleheen</name>
<affiliation><nlm:aff id="A6">University of Cambridge, Cambridge, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A11">Center for Non-communicable Diseases, Karachi, Pakistan</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A12">University of Pennsylvania, US</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name>
<affiliation><nlm:aff id="A1">Veterans Affairs Maryland Health Care System, Baltimore, Maryland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of Maryland School of Medicine, Baltimore, Maryland</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26732560</idno>
<idno type="pmc">4729659</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729659</idno>
<idno type="RBID">PMC:4729659</idno>
<idno type="doi">10.1161/STROKEAHA.115.011328</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">001C77</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C77</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association analysis of young onset stroke identifies a locus on chromosome 10q25 near <italic>HABP2</italic>
</title>
<author><name sortKey="Cheng, Yu Ching" sort="Cheng, Yu Ching" uniqKey="Cheng Y" first="Yu-Ching" last="Cheng">Yu-Ching Cheng</name>
<affiliation><nlm:aff id="A1">Veterans Affairs Maryland Health Care System, Baltimore, Maryland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of Maryland School of Medicine, Baltimore, Maryland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stanne, Tara M" sort="Stanne, Tara M" uniqKey="Stanne T" first="Tara M." last="Stanne">Tara M. Stanne</name>
<affiliation><nlm:aff id="A3">The University of Gothenburg, Gothenburg, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giese, Anne Katrin" sort="Giese, Anne Katrin" uniqKey="Giese A" first="Anne-Katrin" last="Giese">Anne-Katrin Giese</name>
<affiliation><nlm:aff id="A4">University of Rostock, Rostock, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ho, Weang Kee" sort="Ho, Weang Kee" uniqKey="Ho W" first="Weang Kee" last="Ho">Weang Kee Ho</name>
<affiliation><nlm:aff id="A5">University of Nottingham Malaysia Campus, Selangor Darul Ehsa, Malaysia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Traylor, Matthew" sort="Traylor, Matthew" uniqKey="Traylor M" first="Matthew" last="Traylor">Matthew Traylor</name>
<affiliation><nlm:aff id="A6">University of Cambridge, Cambridge, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<affiliation><nlm:aff id="A7">Institut Pasteur de Lille, F-59000 Lille, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name>
<affiliation><nlm:aff id="A8">University of Newcastle, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Malik, Rainer" sort="Malik, Rainer" uniqKey="Malik R" first="Rainer" last="Malik">Rainer Malik</name>
<affiliation><nlm:aff id="A9">Ludwig-Maximilians-Universität München, Munich, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Xu, Huichun" sort="Xu, Huichun" uniqKey="Xu H" first="Huichun" last="Xu">Huichun Xu</name>
<affiliation><nlm:aff id="A2">University of Maryland School of Medicine, Baltimore, Maryland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kittner, Steven J" sort="Kittner, Steven J" uniqKey="Kittner S" first="Steven J." last="Kittner">Steven J. Kittner</name>
<affiliation><nlm:aff id="A1">Veterans Affairs Maryland Health Care System, Baltimore, Maryland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of Maryland School of Medicine, Baltimore, Maryland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cole, John W" sort="Cole, John W" uniqKey="Cole J" first="John W." last="Cole">John W. Cole</name>
<affiliation><nlm:aff id="A1">Veterans Affairs Maryland Health Care System, Baltimore, Maryland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of Maryland School of Medicine, Baltimore, Maryland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="O Onnell, Jeffrey R" sort="O Onnell, Jeffrey R" uniqKey="O Onnell J" first="Jeffrey R." last="O Onnell">Jeffrey R. O Onnell</name>
<affiliation><nlm:aff id="A2">University of Maryland School of Medicine, Baltimore, Maryland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name>
<affiliation><nlm:aff id="A6">University of Cambridge, Cambridge, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Cambridge, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rasheed, Asif" sort="Rasheed, Asif" uniqKey="Rasheed A" first="Asif" last="Rasheed">Asif Rasheed</name>
<affiliation><nlm:aff id="A11">Center for Non-communicable Diseases, Karachi, Pakistan</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhao, Wei" sort="Zhao, Wei" uniqKey="Zhao W" first="Wei" last="Zhao">Wei Zhao</name>
<affiliation><nlm:aff id="A12">University of Pennsylvania, US</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Engelter, Stefan" sort="Engelter, Stefan" uniqKey="Engelter S" first="Stefan" last="Engelter">Stefan Engelter</name>
<affiliation><nlm:aff id="A13">Basel University Hospital, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Grond Ginsbach, Caspar" sort="Grond Ginsbach, Caspar" uniqKey="Grond Ginsbach C" first="Caspar" last="Grond-Ginsbach">Caspar Grond-Ginsbach</name>
<affiliation><nlm:aff id="A14">Heidelberg University Hospital, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kamatani, Yoichiro" sort="Kamatani, Yoichiro" uniqKey="Kamatani Y" first="Yoichiro" last="Kamatani">Yoichiro Kamatani</name>
<affiliation><nlm:aff id="A15">Centre d’Étude du Polymorphisme Humain, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A16">RIKEN Center for Integrative Medical Sciences, Yokohama, Japan</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<affiliation><nlm:aff id="A17">National Genotyping Center, Evry, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A18">Genome Quebec, McGill University, Montreal, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Leys, Didier" sort="Leys, Didier" uniqKey="Leys D" first="Didier" last="Leys">Didier Leys</name>
<affiliation><nlm:aff id="A19">Lille University Hospital, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Thijs, Vincent" sort="Thijs, Vincent" uniqKey="Thijs V" first="Vincent" last="Thijs">Vincent Thijs</name>
<affiliation><nlm:aff id="A20">KU Leuven - University of Leuven, B-3000 Leuven, Belgium</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A21">Vesalius Research Center, VIB, B-3000 Leuven, Belgium</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A22">University Hospitals Leuven, B-3000 Leuven, Belgium</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Metso, Tiina M" sort="Metso, Tiina M" uniqKey="Metso T" first="Tiina M." last="Metso">Tiina M. Metso</name>
<affiliation><nlm:aff id="A23">Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tatlisumak, Turgut" sort="Tatlisumak, Turgut" uniqKey="Tatlisumak T" first="Turgut" last="Tatlisumak">Turgut Tatlisumak</name>
<affiliation><nlm:aff id="A23">Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pezzini, Alessandro" sort="Pezzini, Alessandro" uniqKey="Pezzini A" first="Alessandro" last="Pezzini">Alessandro Pezzini</name>
<affiliation><nlm:aff id="A24">Università degli Studi di Brescia, Brescia, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Parati, Eugenio A" sort="Parati, Eugenio A" uniqKey="Parati E" first="Eugenio A." last="Parati">Eugenio A. Parati</name>
<affiliation><nlm:aff id="A25">Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Norrving, Bo" sort="Norrving, Bo" uniqKey="Norrving B" first="Bo" last="Norrving">Bo Norrving</name>
<affiliation><nlm:aff id="A26">University of Lund, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bevan, Steve" sort="Bevan, Steve" uniqKey="Bevan S" first="Steve" last="Bevan">Steve Bevan</name>
<affiliation><nlm:aff id="A6">University of Cambridge, Cambridge, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rothwell, Peter M" sort="Rothwell, Peter M" uniqKey="Rothwell P" first="Peter M" last="Rothwell">Peter M. Rothwell</name>
<affiliation><nlm:aff id="A27">University of Oxford, John Radcliffe Hospital</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sudlow, Cathie" sort="Sudlow, Cathie" uniqKey="Sudlow C" first="Cathie" last="Sudlow">Cathie Sudlow</name>
<affiliation><nlm:aff id="A28">University of Edinburgh, Edinburgh, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Slowik, Agnieszka" sort="Slowik, Agnieszka" uniqKey="Slowik A" first="Agnieszka" last="Slowik">Agnieszka Slowik</name>
<affiliation><nlm:aff id="A29">Jagiellonian University Medical College, Krakow, Poland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lindgren, Arne" sort="Lindgren, Arne" uniqKey="Lindgren A" first="Arne" last="Lindgren">Arne Lindgren</name>
<affiliation><nlm:aff id="A30">Lund University, Lund, Sweden</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A31">Skåne University Hospital, Lund, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Walters, Matthew R" sort="Walters, Matthew R" uniqKey="Walters M" first="Matthew R" last="Walters">Matthew R. Walters</name>
<affiliation><nlm:aff id="A32">University of Glasgow, Glasgow, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jannes, Jim" sort="Jannes, Jim" uniqKey="Jannes J" first="Jim" last="Jannes">Jim Jannes</name>
<affiliation><nlm:aff id="A33">University of Adelaide, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shen, Jess" sort="Shen, Jess" uniqKey="Shen J" first="Jess" last="Shen">Jess Shen</name>
<affiliation><nlm:aff id="A34">Mount Sinai Hospital, Toronto, Ontario</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Crosslin, David" sort="Crosslin, David" uniqKey="Crosslin D" first="David" last="Crosslin">David Crosslin</name>
<affiliation><nlm:aff id="A35">University of Washington, Seattle, Washington</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Doheny, Kimberly" sort="Doheny, Kimberly" uniqKey="Doheny K" first="Kimberly" last="Doheny">Kimberly Doheny</name>
<affiliation><nlm:aff id="A36">Johns Hopkins University School of Medicine, Baltimore, Maryland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Laurie, Cathy C" sort="Laurie, Cathy C" uniqKey="Laurie C" first="Cathy C." last="Laurie">Cathy C. Laurie</name>
<affiliation><nlm:aff id="A35">University of Washington, Seattle, Washington</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kanse, Sandip M" sort="Kanse, Sandip M" uniqKey="Kanse S" first="Sandip M." last="Kanse">Sandip M. Kanse</name>
<affiliation><nlm:aff id="A37">University of Oslo, Oslo, Norway</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation><nlm:aff id="A35">University of Washington, Seattle, Washington</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation><nlm:aff id="A38">The University of Texas Health Science Center at Houston, Houston, Texas</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name>
<affiliation><nlm:aff id="A39">University of Mississippi Medical Center, Jackson, MS</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hopewell, Jemma C" sort="Hopewell, Jemma C" uniqKey="Hopewell J" first="Jemma C." last="Hopewell">Jemma C. Hopewell</name>
<affiliation><nlm:aff id="A40">University of Oxford, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Strauch, Konstantin" sort="Strauch, Konstantin" uniqKey="Strauch K" first="Konstantin" last="Strauch">Konstantin Strauch</name>
<affiliation><nlm:aff id="A9">Ludwig-Maximilians-Universität München, Munich, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A41">Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name>
<affiliation><nlm:aff id="A9">Ludwig-Maximilians-Universität München, Munich, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A41">Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A42">Partner site Munich Heart Alliance, Munich, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A50">University Hospital Grosshadern, Munich, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name>
<affiliation><nlm:aff id="A41">Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name>
<affiliation><nlm:aff id="A41">Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name>
<affiliation><nlm:aff id="A41">Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A42">Partner site Munich Heart Alliance, Munich, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meisinger, Christine" sort="Meisinger, Christine" uniqKey="Meisinger C" first="Christine" last="Meisinger">Christine Meisinger</name>
<affiliation><nlm:aff id="A41">Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name>
<affiliation><nlm:aff id="A43">Erasmus University Medical Center Rotterdam, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Longstreth, Wt" sort="Longstreth, Wt" uniqKey="Longstreth W" first="Wt" last="Longstreth">Wt Longstreth</name>
<affiliation><nlm:aff id="A35">University of Washington, Seattle, Washington</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meschia, James F" sort="Meschia, James F" uniqKey="Meschia J" first="James F." last="Meschia">James F. Meschia</name>
<affiliation><nlm:aff id="A44">Mayo Clinic, Florida</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<affiliation><nlm:aff id="A45">Boston University School of Medicine, Boston, MA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name>
<affiliation><nlm:aff id="A46">Royal Holloway, University of London, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Worrall, Bradford" sort="Worrall, Bradford" uniqKey="Worrall B" first="Bradford" last="Worrall">Bradford Worrall</name>
<affiliation><nlm:aff id="A47">University of Virginia, Charlottesville, Virginia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jern, Christina" sort="Jern, Christina" uniqKey="Jern C" first="Christina" last="Jern">Christina Jern</name>
<affiliation><nlm:aff id="A3">The University of Gothenburg, Gothenburg, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Levi, Christopher" sort="Levi, Christopher" uniqKey="Levi C" first="Christopher" last="Levi">Christopher Levi</name>
<affiliation><nlm:aff id="A48">John Hunter Hospital, Newcastle, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name>
<affiliation><nlm:aff id="A9">Ludwig-Maximilians-Universität München, Munich, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Boncoraglio, Giorgio B" sort="Boncoraglio, Giorgio B" uniqKey="Boncoraglio G" first="Giorgio B." last="Boncoraglio">Giorgio B. Boncoraglio</name>
<affiliation><nlm:aff id="A25">Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Markus, Hugh S" sort="Markus, Hugh S" uniqKey="Markus H" first="Hugh S." last="Markus">Hugh S. Markus</name>
<affiliation><nlm:aff id="A6">University of Cambridge, Cambridge, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<affiliation><nlm:aff id="A6">University of Cambridge, Cambridge, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A19">Lille University Hospital, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A49">University Hospital of Bordeaux, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rolfs, Arndt" sort="Rolfs, Arndt" uniqKey="Rolfs A" first="Arndt" last="Rolfs">Arndt Rolfs</name>
<affiliation><nlm:aff id="A4">University of Rostock, Rostock, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Saleheen, Danish" sort="Saleheen, Danish" uniqKey="Saleheen D" first="Danish" last="Saleheen">Danish Saleheen</name>
<affiliation><nlm:aff id="A6">University of Cambridge, Cambridge, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A11">Center for Non-communicable Diseases, Karachi, Pakistan</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A12">University of Pennsylvania, US</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name>
<affiliation><nlm:aff id="A1">Veterans Affairs Maryland Health Care System, Baltimore, Maryland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University of Maryland School of Medicine, Baltimore, Maryland</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Stroke; a journal of cerebral circulation</title>
<idno type="ISSN">0039-2499</idno>
<idno type="eISSN">1524-4628</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background and Purpose</title>
<p id="P1">Although a genetic contribution to ischemic stroke is well recognized, only a handful of stroke loci have been identified by large-scale genetic association studies to date. Hypothesizing that genetic effects might be stronger for early- versus late-onset stroke, we conducted a two-stage meta-analysis of genome-wide association studies (GWAS), focusing on stroke cases with an age of onset < 60 years old.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">The Discovery stage of our GWAS included 4,505 cases and 21,968 controls of European, South-Asian and African ancestry, drawn from 6 studies. In Stage 2, we selected the lead genetic variants at loci with association P<5×10<sup>−6</sup>
and performed <italic>in silico</italic>
association analyses in an independent sample of up to 1,003 cases and 7,745 controls.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">One stroke susceptibility locus at 10q25 reached genome-wide significance in the combined analysis of all samples from the Discovery and Follow-up Stages (rs11196288, OR=1.41, P=9.5×10<sup>−9</sup>
). The associated locus is in an intergenic region between <italic>TCF7L2</italic>
and <italic>HABP2</italic>
. In a further analysis in an independent sample, we found that two SNPs in high linkage disequilibrium with rs11196288 were significantly associated with total plasma factor VII-activating protease levels, a product of <italic>HABP2</italic>
.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4"><italic>HABP2</italic>
, which encodes an extracellular serine protease involved in coagulation, fibrinolysis, and inflammatory pathways, may be a genetic susceptibility locus for early-onset stroke.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0235266</journal-id>
<journal-id journal-id-type="pubmed-jr-id">7613</journal-id>
<journal-id journal-id-type="nlm-ta">Stroke</journal-id>
<journal-id journal-id-type="iso-abbrev">Stroke</journal-id>
<journal-title-group><journal-title>Stroke; a journal of cerebral circulation</journal-title>
</journal-title-group>
<issn pub-type="ppub">0039-2499</issn>
<issn pub-type="epub">1524-4628</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26732560</article-id>
<article-id pub-id-type="pmc">4729659</article-id>
<article-id pub-id-type="doi">10.1161/STROKEAHA.115.011328</article-id>
<article-id pub-id-type="manuscript">NIHMS743167</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Genome-wide association analysis of young onset stroke identifies a locus on chromosome 10q25 near <italic>HABP2</italic>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Cheng</surname>
<given-names>Yu-Ching</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stanne</surname>
<given-names>Tara M.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Giese</surname>
<given-names>Anne-Katrin</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ho</surname>
<given-names>Weang Kee</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Traylor</surname>
<given-names>Matthew</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Amouyel</surname>
<given-names>Philippe</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Holliday</surname>
<given-names>Elizabeth G.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Malik</surname>
<given-names>Rainer</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Xu</surname>
<given-names>Huichun</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kittner</surname>
<given-names>Steven J.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cole</surname>
<given-names>John W.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>O’Connell</surname>
<given-names>Jeffrey R.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Danesh</surname>
<given-names>John</given-names>
</name>
<degrees>DPhil, FRCP</degrees>
<xref ref-type="aff" rid="A6">6</xref>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rasheed</surname>
<given-names>Asif</given-names>
</name>
<degrees>MBBS</degrees>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhao</surname>
<given-names>Wei</given-names>
</name>
<degrees>MSc</degrees>
<xref ref-type="aff" rid="A12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Engelter</surname>
<given-names>Stefan</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Grond-Ginsbach</surname>
<given-names>Caspar</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kamatani</surname>
<given-names>Yoichiro</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A15">15</xref>
<xref ref-type="aff" rid="A16">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lathrop</surname>
<given-names>Mark</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A17">17</xref>
<xref ref-type="aff" rid="A18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leys</surname>
<given-names>Didier</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thijs</surname>
<given-names>Vincent</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A20">20</xref>
<xref ref-type="aff" rid="A21">21</xref>
<xref ref-type="aff" rid="A22">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Metso</surname>
<given-names>Tiina M.</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A23">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tatlisumak</surname>
<given-names>Turgut</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A23">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pezzini</surname>
<given-names>Alessandro</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A24">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Parati</surname>
<given-names>Eugenio A.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A25">25</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Norrving</surname>
<given-names>Bo</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A26">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bevan</surname>
<given-names>Steve</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rothwell</surname>
<given-names>Peter M</given-names>
</name>
<degrees>MD, PhD, FRCP</degrees>
<xref ref-type="aff" rid="A27">27</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sudlow</surname>
<given-names>Cathie</given-names>
</name>
<degrees>DPhil, FRCP</degrees>
<xref ref-type="aff" rid="A28">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Slowik</surname>
<given-names>Agnieszka</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A29">29</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lindgren</surname>
<given-names>Arne</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A30">30</xref>
<xref ref-type="aff" rid="A31">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Walters</surname>
<given-names>Matthew R</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A32">32</xref>
</contrib>
<contrib contrib-type="author"><collab>WTCCC-2 Consortium</collab>
</contrib>
<contrib contrib-type="author"><name><surname>Jannes</surname>
<given-names>Jim</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A33">33</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shen</surname>
<given-names>Jess</given-names>
</name>
<degrees>MSc</degrees>
<xref ref-type="aff" rid="A34">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Crosslin</surname>
<given-names>David</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A35">35</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Doheny</surname>
<given-names>Kimberly</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A36">36</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Laurie</surname>
<given-names>Cathy C.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A35">35</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kanse</surname>
<given-names>Sandip M.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A37">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bis</surname>
<given-names>Joshua C.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A35">35</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fornage</surname>
<given-names>Myriam</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A38">38</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mosley</surname>
<given-names>Thomas H.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A39">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hopewell</surname>
<given-names>Jemma C.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A40">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Strauch</surname>
<given-names>Konstantin</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A9">9</xref>
<xref ref-type="aff" rid="A41">41</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Müller-Nurasyid</surname>
<given-names>Martina</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A9">9</xref>
<xref ref-type="aff" rid="A41">41</xref>
<xref ref-type="aff" rid="A42">42</xref>
<xref ref-type="aff" rid="A50">50</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gieger</surname>
<given-names>Christian</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A41">41</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Waldenberger</surname>
<given-names>Melanie</given-names>
</name>
<degrees>PhD, MPH</degrees>
<xref ref-type="aff" rid="A41">41</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peters</surname>
<given-names>Annette</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A41">41</xref>
<xref ref-type="aff" rid="A42">42</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meisinger</surname>
<given-names>Christine</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A41">41</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ikram</surname>
<given-names>M. Arfan</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A43">43</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Longstreth</surname>
<given-names>WT</given-names>
<suffix>Jr</suffix>
</name>
<degrees>MD, MPH</degrees>
<xref ref-type="aff" rid="A35">35</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meschia</surname>
<given-names>James F.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A44">44</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Seshadri</surname>
<given-names>Sudha</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A45">45</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sharma</surname>
<given-names>Pankaj</given-names>
</name>
<degrees>PhD, MD</degrees>
<xref ref-type="aff" rid="A46">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Worrall</surname>
<given-names>Bradford</given-names>
</name>
<degrees>MD, MSc</degrees>
<xref ref-type="aff" rid="A47">47</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jern</surname>
<given-names>Christina</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Levi</surname>
<given-names>Christopher</given-names>
</name>
<degrees>MBBS</degrees>
<xref ref-type="aff" rid="A48">48</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dichgans</surname>
<given-names>Martin</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Boncoraglio</surname>
<given-names>Giorgio B.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A25">25</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Markus</surname>
<given-names>Hugh S.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Debette</surname>
<given-names>Stephanie</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A6">6</xref>
<xref ref-type="aff" rid="A19">19</xref>
<xref ref-type="aff" rid="A49">49</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rolfs</surname>
<given-names>Arndt</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Saleheen</surname>
<given-names>Danish</given-names>
</name>
<degrees>MBBS, PhD</degrees>
<xref ref-type="aff" rid="A6">6</xref>
<xref ref-type="aff" rid="A11">11</xref>
<xref ref-type="aff" rid="A12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mitchell</surname>
<given-names>Braxton D.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Veterans Affairs Maryland Health Care System, Baltimore, Maryland</aff>
<aff id="A2"><label>2</label>
University of Maryland School of Medicine, Baltimore, Maryland</aff>
<aff id="A3"><label>3</label>
The University of Gothenburg, Gothenburg, Sweden</aff>
<aff id="A4"><label>4</label>
University of Rostock, Rostock, Germany</aff>
<aff id="A5"><label>5</label>
University of Nottingham Malaysia Campus, Selangor Darul Ehsa, Malaysia</aff>
<aff id="A6"><label>6</label>
University of Cambridge, Cambridge, UK</aff>
<aff id="A7"><label>7</label>
Institut Pasteur de Lille, F-59000 Lille, France</aff>
<aff id="A8"><label>8</label>
University of Newcastle, Australia</aff>
<aff id="A9"><label>9</label>
Ludwig-Maximilians-Universität München, Munich, Germany</aff>
<aff id="A10"><label>10</label>
Wellcome Trust Sanger Institute, Cambridge, UK</aff>
<aff id="A11"><label>11</label>
Center for Non-communicable Diseases, Karachi, Pakistan</aff>
<aff id="A12"><label>12</label>
University of Pennsylvania, US</aff>
<aff id="A13"><label>13</label>
Basel University Hospital, Switzerland</aff>
<aff id="A14"><label>14</label>
Heidelberg University Hospital, Germany</aff>
<aff id="A15"><label>15</label>
Centre d’Étude du Polymorphisme Humain, Paris, France</aff>
<aff id="A16"><label>16</label>
RIKEN Center for Integrative Medical Sciences, Yokohama, Japan</aff>
<aff id="A17"><label>17</label>
National Genotyping Center, Evry, France</aff>
<aff id="A18"><label>18</label>
Genome Quebec, McGill University, Montreal, Canada</aff>
<aff id="A19"><label>19</label>
Lille University Hospital, France</aff>
<aff id="A20"><label>20</label>
KU Leuven - University of Leuven, B-3000 Leuven, Belgium</aff>
<aff id="A21"><label>21</label>
Vesalius Research Center, VIB, B-3000 Leuven, Belgium</aff>
<aff id="A22"><label>22</label>
University Hospitals Leuven, B-3000 Leuven, Belgium</aff>
<aff id="A23"><label>23</label>
Helsinki University Central Hospital, Helsinki, Finland</aff>
<aff id="A24"><label>24</label>
Università degli Studi di Brescia, Brescia, Italy</aff>
<aff id="A25"><label>25</label>
Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy</aff>
<aff id="A26"><label>26</label>
University of Lund, Sweden</aff>
<aff id="A27"><label>27</label>
University of Oxford, John Radcliffe Hospital</aff>
<aff id="A28"><label>28</label>
University of Edinburgh, Edinburgh, UK</aff>
<aff id="A29"><label>29</label>
Jagiellonian University Medical College, Krakow, Poland</aff>
<aff id="A30"><label>30</label>
Lund University, Lund, Sweden</aff>
<aff id="A31"><label>31</label>
Skåne University Hospital, Lund, Sweden</aff>
<aff id="A32"><label>32</label>
University of Glasgow, Glasgow, UK</aff>
<aff id="A33"><label>33</label>
University of Adelaide, Australia</aff>
<aff id="A34"><label>34</label>
Mount Sinai Hospital, Toronto, Ontario</aff>
<aff id="A35"><label>35</label>
University of Washington, Seattle, Washington</aff>
<aff id="A36"><label>36</label>
Johns Hopkins University School of Medicine, Baltimore, Maryland</aff>
<aff id="A37"><label>37</label>
University of Oslo, Oslo, Norway</aff>
<aff id="A38"><label>38</label>
The University of Texas Health Science Center at Houston, Houston, Texas</aff>
<aff id="A39"><label>39</label>
University of Mississippi Medical Center, Jackson, MS</aff>
<aff id="A40"><label>40</label>
University of Oxford, Oxford, UK</aff>
<aff id="A41"><label>41</label>
Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</aff>
<aff id="A42"><label>42</label>
Partner site Munich Heart Alliance, Munich, Germany</aff>
<aff id="A43"><label>43</label>
Erasmus University Medical Center Rotterdam, Netherlands</aff>
<aff id="A44"><label>44</label>
Mayo Clinic, Florida</aff>
<aff id="A45"><label>45</label>
Boston University School of Medicine, Boston, MA</aff>
<aff id="A46"><label>46</label>
Royal Holloway, University of London, UK</aff>
<aff id="A47"><label>47</label>
University of Virginia, Charlottesville, Virginia</aff>
<aff id="A48"><label>48</label>
John Hunter Hospital, Newcastle, Australia</aff>
<aff id="A49"><label>49</label>
University Hospital of Bordeaux, France</aff>
<aff id="A50"><label>50</label>
University Hospital Grosshadern, Munich, Germany</aff>
<author-notes><corresp id="FN1">Corresponding Author: Braxton D Mitchell, PhD, 685 W. Baltimore St., MSTF 302, Baltimore, Maryland 21201, University of Maryland, School of Medicine, <email>bmitchel@medicine.umaryland.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>9</day>
<month>12</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>05</day>
<month>1</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="ppub"><month>2</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>2</month>
<year>2017</year>
</pub-date>
<volume>47</volume>
<issue>2</issue>
<fpage>307</fpage>
<lpage>316</lpage>
<pmc-comment>elocation-id from pubmed: 10.1161/STROKEAHA.115.011328</pmc-comment>
<abstract><sec id="S1"><title>Background and Purpose</title>
<p id="P1">Although a genetic contribution to ischemic stroke is well recognized, only a handful of stroke loci have been identified by large-scale genetic association studies to date. Hypothesizing that genetic effects might be stronger for early- versus late-onset stroke, we conducted a two-stage meta-analysis of genome-wide association studies (GWAS), focusing on stroke cases with an age of onset < 60 years old.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">The Discovery stage of our GWAS included 4,505 cases and 21,968 controls of European, South-Asian and African ancestry, drawn from 6 studies. In Stage 2, we selected the lead genetic variants at loci with association P<5×10<sup>−6</sup>
and performed <italic>in silico</italic>
association analyses in an independent sample of up to 1,003 cases and 7,745 controls.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">One stroke susceptibility locus at 10q25 reached genome-wide significance in the combined analysis of all samples from the Discovery and Follow-up Stages (rs11196288, OR=1.41, P=9.5×10<sup>−9</sup>
). The associated locus is in an intergenic region between <italic>TCF7L2</italic>
and <italic>HABP2</italic>
. In a further analysis in an independent sample, we found that two SNPs in high linkage disequilibrium with rs11196288 were significantly associated with total plasma factor VII-activating protease levels, a product of <italic>HABP2</italic>
.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4"><italic>HABP2</italic>
, which encodes an extracellular serine protease involved in coagulation, fibrinolysis, and inflammatory pathways, may be a genetic susceptibility locus for early-onset stroke.</p>
</sec>
</abstract>
<kwd-group><kwd>ischemic stroke</kwd>
<kwd>genome-wide analysis</kwd>
<kwd>genetics</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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