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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hyperintense vessels on acute stroke Fluid-attenuated Inversion Recovery imaging: Associations with clinical and other MRI findings</title><author><name sortKey="Cheng, Bastian" sort="Cheng, Bastian" uniqKey="Cheng B" first="Bastian" last="Cheng">Bastian Cheng</name><affiliation><nlm:aff id="A1">Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Ebinger, Martin" sort="Ebinger, Martin" uniqKey="Ebinger M" first="Martin" last="Ebinger">Martin Ebinger</name><affiliation><nlm:aff id="A2">Centrum für Schlaganfallforschung Berlin, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Kufner, Anna" sort="Kufner, Anna" uniqKey="Kufner A" first="Anna" last="Kufner">Anna Kufner</name><affiliation><nlm:aff id="A2">Centrum für Schlaganfallforschung Berlin, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Kohrmann, Martin" sort="Kohrmann, Martin" uniqKey="Kohrmann M" first="Martin" last="Köhrmann">Martin Köhrmann</name><affiliation><nlm:aff id="A3">Klinik für Neurologie, Universität Erlangen-Nürnberg, Maximiliansplatz 2, 91054 Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Wu, Ona" sort="Wu, Ona" uniqKey="Wu O" first="Ona" last="Wu">Ona Wu</name><affiliation><nlm:aff id="A4">Athinoula A MartinosCenter for Biomedical Imaging, Department of Radiology, Massachusetts GeneralHospital, Harvard MedicalSchool, 25 Shattuck Street Boston, MA02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kang, Dong Wha" sort="Kang, Dong Wha" uniqKey="Kang D" first="Dong-Wha" last="Kang">Dong-Wha Kang</name><affiliation><nlm:aff id="A5">Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-ku, Seoul 138-736, South Korea</nlm:aff></affiliation></author><author><name sortKey="Liebeskind, David" sort="Liebeskind, David" uniqKey="Liebeskind D" first="David" last="Liebeskind">David Liebeskind</name><affiliation><nlm:aff id="A6">Department of Neurology, University of California, 1111 Franklin St., Oakland, CA94607, USA</nlm:aff></affiliation></author><author><name sortKey="Tourdias, Thomas" sort="Tourdias, Thomas" uniqKey="Tourdias T" first="Thomas" last="Tourdias">Thomas Tourdias</name><affiliation><nlm:aff id="A7">Univ. de Bordeaux, CHU de Bordeaux, Service de NeuroImagerie Diagnostique de Thérapeutique, Place Amélie Raba Léon, F-33000 Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="Singer, Oliver C" sort="Singer, Oliver C" uniqKey="Singer O" first="Oliver C." last="Singer">Oliver C. Singer</name><affiliation><nlm:aff id="A8">Kliniken für Neuroradiologie, Universitätsklinikum Erlangen-Nürnberg, Maximiliansplatz 2, 91054 Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Christensen, Soren" sort="Christensen, Soren" uniqKey="Christensen S" first="Soren" last="Christensen">Soren Christensen</name><affiliation><nlm:aff id="A9">Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville Victoria, Australia 3050</nlm:aff></affiliation></author><author><name sortKey="Warach, Steve" sort="Warach, Steve" uniqKey="Warach S" first="Steve" last="Warach">Steve Warach</name><affiliation><nlm:aff id="A10">National Institute of Neurological Disorders and Stroke, 10 Center Drive Bethesda, 20892-1063MD, VereinigteStaaten</nlm:aff></affiliation></author><author><name sortKey="Luby, Marie" sort="Luby, Marie" uniqKey="Luby M" first="Marie" last="Luby">Marie Luby</name><affiliation><nlm:aff id="A10">National Institute of Neurological Disorders and Stroke, 10 Center Drive Bethesda, 20892-1063MD, VereinigteStaaten</nlm:aff></affiliation></author><author><name sortKey="Fiebach, Jochen B" sort="Fiebach, Jochen B" uniqKey="Fiebach J" first="Jochen B." last="Fiebach">Jochen B. Fiebach</name><affiliation><nlm:aff id="A2">Centrum für Schlaganfallforschung Berlin, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Fiehler, Jens" sort="Fiehler, Jens" uniqKey="Fiehler J" first="Jens" last="Fiehler">Jens Fiehler</name><affiliation><nlm:aff id="A11">Klinik und Poliklinik für Neuroradiologische Diagnostik und Intervention, Unversitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gerloff, Christian" sort="Gerloff, Christian" uniqKey="Gerloff C" first="Christian" last="Gerloff">Christian Gerloff</name><affiliation><nlm:aff id="A1">Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name><affiliation><nlm:aff id="A1">Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22933582</idno><idno type="pmc">3495102</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495102</idno><idno type="RBID">PMC:3495102</idno><idno type="doi">10.1161/STROKEAHA.112.658906</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001C71</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C71</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Hyperintense vessels on acute stroke Fluid-attenuated Inversion Recovery imaging: Associations with clinical and other MRI findings</title><author><name sortKey="Cheng, Bastian" sort="Cheng, Bastian" uniqKey="Cheng B" first="Bastian" last="Cheng">Bastian Cheng</name><affiliation><nlm:aff id="A1">Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Ebinger, Martin" sort="Ebinger, Martin" uniqKey="Ebinger M" first="Martin" last="Ebinger">Martin Ebinger</name><affiliation><nlm:aff id="A2">Centrum für Schlaganfallforschung Berlin, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Kufner, Anna" sort="Kufner, Anna" uniqKey="Kufner A" first="Anna" last="Kufner">Anna Kufner</name><affiliation><nlm:aff id="A2">Centrum für Schlaganfallforschung Berlin, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Kohrmann, Martin" sort="Kohrmann, Martin" uniqKey="Kohrmann M" first="Martin" last="Köhrmann">Martin Köhrmann</name><affiliation><nlm:aff id="A3">Klinik für Neurologie, Universität Erlangen-Nürnberg, Maximiliansplatz 2, 91054 Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Wu, Ona" sort="Wu, Ona" uniqKey="Wu O" first="Ona" last="Wu">Ona Wu</name><affiliation><nlm:aff id="A4">Athinoula A MartinosCenter for Biomedical Imaging, Department of Radiology, Massachusetts GeneralHospital, Harvard MedicalSchool, 25 Shattuck Street Boston, MA02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kang, Dong Wha" sort="Kang, Dong Wha" uniqKey="Kang D" first="Dong-Wha" last="Kang">Dong-Wha Kang</name><affiliation><nlm:aff id="A5">Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-ku, Seoul 138-736, South Korea</nlm:aff></affiliation></author><author><name sortKey="Liebeskind, David" sort="Liebeskind, David" uniqKey="Liebeskind D" first="David" last="Liebeskind">David Liebeskind</name><affiliation><nlm:aff id="A6">Department of Neurology, University of California, 1111 Franklin St., Oakland, CA94607, USA</nlm:aff></affiliation></author><author><name sortKey="Tourdias, Thomas" sort="Tourdias, Thomas" uniqKey="Tourdias T" first="Thomas" last="Tourdias">Thomas Tourdias</name><affiliation><nlm:aff id="A7">Univ. de Bordeaux, CHU de Bordeaux, Service de NeuroImagerie Diagnostique de Thérapeutique, Place Amélie Raba Léon, F-33000 Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="Singer, Oliver C" sort="Singer, Oliver C" uniqKey="Singer O" first="Oliver C." last="Singer">Oliver C. Singer</name><affiliation><nlm:aff id="A8">Kliniken für Neuroradiologie, Universitätsklinikum Erlangen-Nürnberg, Maximiliansplatz 2, 91054 Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Christensen, Soren" sort="Christensen, Soren" uniqKey="Christensen S" first="Soren" last="Christensen">Soren Christensen</name><affiliation><nlm:aff id="A9">Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville Victoria, Australia 3050</nlm:aff></affiliation></author><author><name sortKey="Warach, Steve" sort="Warach, Steve" uniqKey="Warach S" first="Steve" last="Warach">Steve Warach</name><affiliation><nlm:aff id="A10">National Institute of Neurological Disorders and Stroke, 10 Center Drive Bethesda, 20892-1063MD, VereinigteStaaten</nlm:aff></affiliation></author><author><name sortKey="Luby, Marie" sort="Luby, Marie" uniqKey="Luby M" first="Marie" last="Luby">Marie Luby</name><affiliation><nlm:aff id="A10">National Institute of Neurological Disorders and Stroke, 10 Center Drive Bethesda, 20892-1063MD, VereinigteStaaten</nlm:aff></affiliation></author><author><name sortKey="Fiebach, Jochen B" sort="Fiebach, Jochen B" uniqKey="Fiebach J" first="Jochen B." last="Fiebach">Jochen B. Fiebach</name><affiliation><nlm:aff id="A2">Centrum für Schlaganfallforschung Berlin, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Fiehler, Jens" sort="Fiehler, Jens" uniqKey="Fiehler J" first="Jens" last="Fiehler">Jens Fiehler</name><affiliation><nlm:aff id="A11">Klinik und Poliklinik für Neuroradiologische Diagnostik und Intervention, Unversitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gerloff, Christian" sort="Gerloff, Christian" uniqKey="Gerloff C" first="Christian" last="Gerloff">Christian Gerloff</name><affiliation><nlm:aff id="A1">Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name><affiliation><nlm:aff id="A1">Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany</nlm:aff></affiliation></author></analytic><series><title level="j">Stroke; a journal of cerebral circulation</title><idno type="ISSN">0039-2499</idno><idno type="eISSN">1524-4628</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background and Purpose</title><p id="P1">Hyperintense vessels (HV) have been observed in Fluid-Attenuated Inversion Recovery (FLAIR) imaging of patients with acute ischemic stroke and been linked to slow flow in collateral arterial circulation. Given the potential importance of HV, we used a large, multicentre dataset of stroke patients to clarify which clinical and imaging factors play a role in HV.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We analyzed data of 516 patients from the previously published PRE-FLAIR study. Patients were studied by MRI within 12 hours of symptom onset. HV were defined as hyperintensities in FLAIR corresponding to the typical course of a blood vessel that was not considered the proximal, occluded main artery ipsilateral to the diffusion restriction. Presence of HV was rated by two observers and related to clinical and imaging findings.</p></sec><sec id="S3"><title>Results</title><p id="P3">Presence of HV was identified in 240 of all 516 patients (47%). Patients with HV showed larger initial ischemic lesion volumes (median 12.3 vs. 4.9 ml; p<0.001) and a more severe clinical impairment (median NIHSS 10.5 vs. 6; p<0.001). In 198 patients with MR-angiography, HV were found in 80% of patients with vessel occlusion and in 17% without vessel occlusion. In a multivariable logistic regression model, vessel occlusion was associated with HV (OR 21.7%; 95% CI 9.6–49.9, p < 0.001). HV detected vessel occlusion with a specificity of 0.86 (95% CI 0.80–0.90) and sensitivity of 0.76 (95% CI 0.69–0.83).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">HV are a common finding associated with proximal arterial occlusions and more severe strokes. HV predict arterial occlusion with high diagnostic accuracy.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0235266</journal-id><journal-id journal-id-type="pubmed-jr-id">7613</journal-id><journal-id journal-id-type="nlm-ta">Stroke</journal-id><journal-id journal-id-type="iso-abbrev">Stroke</journal-id><journal-title-group><journal-title>Stroke; a journal of cerebral circulation</journal-title></journal-title-group><issn pub-type="ppub">0039-2499</issn><issn pub-type="epub">1524-4628</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22933582</article-id><article-id pub-id-type="pmc">3495102</article-id><article-id pub-id-type="doi">10.1161/STROKEAHA.112.658906</article-id><article-id pub-id-type="manuscript">NIHMS406650</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Hyperintense vessels on acute stroke Fluid-attenuated Inversion Recovery imaging: Associations with clinical and other MRI findings</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cheng</surname><given-names>Bastian</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref rid="FN2" ref-type="author-notes">*</xref><email>b.cheng@uke.uni-hamburg.de</email></contrib><contrib contrib-type="author"><name><surname>Ebinger</surname><given-names>Martin</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A2">2</xref><xref rid="FN2" ref-type="author-notes">*</xref><email>martin.ebinger@charite.de</email></contrib><contrib contrib-type="author"><name><surname>Kufner</surname><given-names>Anna</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="A2">2</xref><email>anna.kufner@charite.de</email></contrib><contrib contrib-type="author"><name><surname>Köhrmann</surname><given-names>Martin</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">3</xref><email>Martin.Koehrmann@uk-erlangen.de</email></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Ona</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A4">4</xref><email>ona@nmr.mgh.harvard.edu</email></contrib><contrib contrib-type="author"><name><surname>Kang</surname><given-names>Dong-Wha</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A5">5</xref><email>dwkang@amc.seoul.kr</email></contrib><contrib contrib-type="author"><name><surname>Liebeskind</surname><given-names>David</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">6</xref><email>davidliebeskind@yahoo.com</email></contrib><contrib contrib-type="author"><name><surname>Tourdias</surname><given-names>Thomas</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A7">7</xref><email>thomas.tourdias@chu-bordeaux.fr</email></contrib><contrib contrib-type="author"><name><surname>Singer</surname><given-names>Oliver C.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A8">8</xref><email>O.Singer@em.uni-frankfurt.de</email></contrib><contrib contrib-type="author"><name><surname>Christensen</surname><given-names>Soren</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A9">9</xref><email>sorench@gmail.com</email></contrib><contrib contrib-type="author"><name><surname>Warach</surname><given-names>Steve</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A10">10</xref><email>WarachS@ninds.nih.gov</email></contrib><contrib contrib-type="author"><name><surname>Luby</surname><given-names>Marie</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A10">10</xref><email>LubyM@ninds.nih.gov</email></contrib><contrib contrib-type="author"><name><surname>Fiebach</surname><given-names>Jochen B.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A2">2</xref><email>jochen.fiebach@charite.de</email></contrib><contrib contrib-type="author"><name><surname>Fiehler</surname><given-names>Jens</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A11">11</xref><email>fiehler@uke.de</email></contrib><contrib contrib-type="author"><name><surname>Gerloff</surname><given-names>Christian</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><email>gerloff@uke.de</email></contrib><contrib contrib-type="author"><name><surname>Thomalla</surname><given-names>Götz</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><email>thomalla@uke.uni-hamburg.de</email></contrib><on-behalf-of>On behalf of the STIR Investigators</on-behalf-of></contrib-group><aff id="A1"><label>1</label>Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany</aff><aff id="A2"><label>2</label>Centrum für Schlaganfallforschung Berlin, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany</aff><aff id="A3"><label>3</label>Klinik für Neurologie, Universität Erlangen-Nürnberg, Maximiliansplatz 2, 91054 Erlangen, Germany</aff><aff id="A4"><label>4</label>Athinoula A MartinosCenter for Biomedical Imaging, Department of Radiology, Massachusetts GeneralHospital, Harvard MedicalSchool, 25 Shattuck Street Boston, MA02115, USA</aff><aff id="A5"><label>5</label>Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-ku, Seoul 138-736, South Korea</aff><aff id="A6"><label>6</label>Department of Neurology, University of California, 1111 Franklin St., Oakland, CA94607, USA</aff><aff id="A7"><label>7</label>Univ. de Bordeaux, CHU de Bordeaux, Service de NeuroImagerie Diagnostique de Thérapeutique, Place Amélie Raba Léon, F-33000 Bordeaux, France</aff><aff id="A8"><label>8</label>Kliniken für Neuroradiologie, Universitätsklinikum Erlangen-Nürnberg, Maximiliansplatz 2, 91054 Erlangen, Germany</aff><aff id="A9"><label>9</label>Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville Victoria, Australia 3050</aff><aff id="A10"><label>10</label>National Institute of Neurological Disorders and Stroke, 10 Center Drive Bethesda, 20892-1063MD, VereinigteStaaten</aff><aff id="A11"><label>11</label>Klinik und Poliklinik für Neuroradiologische Diagnostik und Intervention, Unversitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany</aff><author-notes><corresp id="FN1">Corresponding author: Bastian Cheng, Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany, Tel: +49-40-741053770, Fax: +49-7410-56721, <email>b.cheng@uke.uni-hamburg.de</email></corresp><fn id="FN2" fn-type="equal"><label>*</label><p>These two authors contributed equally.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>4</day><month>10</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>28</day><month>8</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>11</month><year>2013</year></pub-date><volume>43</volume><issue>11</issue><fpage>2957</fpage><lpage>2961</lpage><abstract><sec id="S1"><title>Background and Purpose</title><p id="P1">Hyperintense vessels (HV) have been observed in Fluid-Attenuated Inversion Recovery (FLAIR) imaging of patients with acute ischemic stroke and been linked to slow flow in collateral arterial circulation. Given the potential importance of HV, we used a large, multicentre dataset of stroke patients to clarify which clinical and imaging factors play a role in HV.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We analyzed data of 516 patients from the previously published PRE-FLAIR study. Patients were studied by MRI within 12 hours of symptom onset. HV were defined as hyperintensities in FLAIR corresponding to the typical course of a blood vessel that was not considered the proximal, occluded main artery ipsilateral to the diffusion restriction. Presence of HV was rated by two observers and related to clinical and imaging findings.</p></sec><sec id="S3"><title>Results</title><p id="P3">Presence of HV was identified in 240 of all 516 patients (47%). Patients with HV showed larger initial ischemic lesion volumes (median 12.3 vs. 4.9 ml; p<0.001) and a more severe clinical impairment (median NIHSS 10.5 vs. 6; p<0.001). In 198 patients with MR-angiography, HV were found in 80% of patients with vessel occlusion and in 17% without vessel occlusion. In a multivariable logistic regression model, vessel occlusion was associated with HV (OR 21.7%; 95% CI 9.6–49.9, p < 0.001). HV detected vessel occlusion with a specificity of 0.86 (95% CI 0.80–0.90) and sensitivity of 0.76 (95% CI 0.69–0.83).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">HV are a common finding associated with proximal arterial occlusions and more severe strokes. HV predict arterial occlusion with high diagnostic accuracy.</p></sec></abstract><kwd-group><kwd>magnetic resonance imaging</kwd><kwd>diffusion-weighted fluid-attenuated inversion recovery stroke</kwd><kwd>acute</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source><award-id>R01 NS063925 || NS</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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