Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer
Identifieur interne : 001C59 ( Pmc/Corpus ); précédent : 001C58; suivant : 001C60Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer
Auteurs : Jiajun Shi ; Yanfeng Zhang ; Wei Zheng ; Kyriaki Michailidou ; Maya Ghoussaini ; Manjeet K. Bolla ; Qin Wang ; Joe Dennis ; Michael Lush ; Roger L. Milne ; Xiao-Ou Shu ; Jonathan Beesley ; Siddhartha Kar ; Irene L. Andrulis ; Hoda Anton-Culver ; Volker Arndt ; Matthias W. Beckmann ; Zhiguo Zhao ; Xingyi Guo ; Javier Benitez ; Alicia Beeghly-Fadiel ; William Blot ; Natalia V. Bogdanova ; Stig E. Bojesen ; Hiltrud Brauch ; Hermann Brenner ; Louise Brinton ; Annegien Broeks ; Thomas Brüning ; Barbara Burwinkel ; Hui Cai ; Sander Canisius ; Jenny Chang-Claude ; Ji-Yeob Choi ; Fergus J. Couch ; Angela Cox ; Simon S. Cross ; Kamila Czene ; Hatef Darabi ; Peter Devilee ; Arnaud Droit ; Thilo Dork ; Peter A. Fasching ; Olivia Fletcher ; Henrik Flyger ; Florentia Fostira ; Valerie Gaborieau ; Montserrat García-Closas ; Graham G. Giles ; Pascal Guenel ; Christopher A. Haiman ; Ute Hamann ; Mikael Hartman ; Hui Miao ; Antoinette Hollestelle ; John L. Hopper ; Chia-Ni Hsiung ; Hidemi Ito ; Anna Jakubowska ; Nichola Johnson ; Diana Torres ; Maria Kabisch ; Daehee Kang ; Sofia Khan ; Julia A. Knight ; Veli-Matti Kosma ; Diether Lambrechts ; Jingmei Li ; Annika Lindblom ; Artitaya Lophatananon ; Jan Lubinski ; Arto Mannermaa ; Siranoush Manoukian ; Loic Le Marchand ; Sara Margolin ; Frederik Marme ; Keitaro Matsuo ; Catriona Mclean ; Alfons Meindl ; Kenneth Muir ; Susan L. Neuhausen ; Heli Nevanlinna ; Silje Nord ; Anne-Lise B Rresen-Dale ; Janet E. Olson ; Nick Orr ; Ans M. W. Van Den Ouweland ; Paolo Peterlongo ; Thomas Choudary Putti ; Anja Rudolph ; Suleeporn Sangrajrang ; Elinor J. Sawyer ; Marjanka K. Schmidt ; Rita K. Schmutzler ; Chen-Yang Shen ; Ming-Feng Hou ; Matha J. Shrubsole ; Melissa C. Southey ; Anthony Swerdlow ; Soo Hwang Teo ; Bernard Thienpont ; Amanda E. Toland ; Robert A. E. M. Tollenaar ; Ian Tomlinson ; Therese Truong ; Chiu-Chen Tseng ; Wanqing Wen ; Robert Winqvist ; Anna H. Wu ; Cheng Har Yip ; Pilar M. Zamora ; Ying Zheng ; Giuseppe Floris ; Ching-Yu Cheng ; Maartje J. Hooning ; John W. M. Martens ; Caroline Seynaeve ; Vessela N. Kristensen ; Per Hall ; Paul D. P. Pharoah ; Jacques Simard ; Georgia Chenevix-Trench ; Alison M. Dunning ; Antonis C. Antoniou ; Douglas F. Easton ; Qiuyin Cai ; Jirong LongSource :
- International journal of cancer [ 0020-7136 ] ; 2016.
Abstract
Previous genome-wide association studies among women of European ancestry identified two independent breast cancer susceptibility loci represented by single nucleotide polymorphisms (SNPs) rs13281615 and rs11780156 at 8q24. We conducted a fine-mapping study across 2.06 Mb (chr8:127,561,724 −129,624,067, hg19) in 55,540 breast cancer cases and 51,168 controls within the Breast Cancer Association Consortium. We found three additional independent association signals in women of European ancestry, represented by rs35961416 (OR = 0.95, 95% CI = 0.93-0.97, conditional
Url:
DOI: 10.1002/ijc.30150
PubMed: 27087578
PubMed Central: 5110427
Links to Exploration step
PMC:5110427Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer</title><author><name sortKey="Shi, Jiajun" sort="Shi, Jiajun" uniqKey="Shi J" first="Jiajun" last="Shi">Jiajun Shi</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Zhang, Yanfeng" sort="Zhang, Yanfeng" uniqKey="Zhang Y" first="Yanfeng" last="Zhang">Yanfeng Zhang</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Lush, Michael" sort="Lush, Michael" uniqKey="Lush M" first="Michael" last="Lush">Michael Lush</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A4">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria 3053, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Victoria 3053, Australia</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A6">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Kar, Siddhartha" sort="Kar, Siddhartha" uniqKey="Kar S" first="Siddhartha" last="Kar">Siddhartha Kar</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A7">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A9">Department of Epidemiology, University of California Irvine, Irvine, CA 92697, USA</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A10">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A11">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany</nlm:aff></affiliation></author><author><name sortKey="Zhao, Zhiguo" sort="Zhao, Zhiguo" uniqKey="Zhao Z" first="Zhiguo" last="Zhao">Zhiguo Zhao</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Guo, Xingyi" sort="Guo, Xingyi" uniqKey="Guo X" first="Xingyi" last="Guo">Xingyi Guo</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A12">Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid 28029, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Beeghly Fadiel, Alicia" sort="Beeghly Fadiel, Alicia" uniqKey="Beeghly Fadiel A" first="Alicia" last="Beeghly-Fadiel">Alicia Beeghly-Fadiel</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Blot, William" sort="Blot, William" uniqKey="Blot W" first="William" last="Blot">William Blot</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A14">International Epidemiology Institute, Rockville, MD 20850, USA</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="A15">Department of Radiation Oncology, Hannover Medical School, Hannover 30625, Germany</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A16">Copenhagen General Population Study, Herlev Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A19">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart 70376, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A20">University of Tübingen, Tübingen 72074, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A21">German Cancer Consortium, German Cancer Research Center(DKFZ), Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A10">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg 69120, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A21">German Cancer Consortium, German Cancer Research Center(DKFZ), Heidelberg 69120, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name><affiliation><nlm:aff id="A23">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="A24">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam 1066 CX, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="A25">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Bochum 44789, Germany</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="A26">Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg 69120, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Molecular Epidemiology Group, German Cancer Research Center, Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Cai, Hui" sort="Cai, Hui" uniqKey="Cai H" first="Hui" last="Cai">Hui Cai</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Canisius, Sander" sort="Canisius, Sander" uniqKey="Canisius S" first="Sander" last="Canisius">Sander Canisius</name><affiliation><nlm:aff id="A28">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A29">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name><affiliation><nlm:aff id="A30">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A32">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A33">Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="A34">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A35">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="A35">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="A36">Separtment of Pathology, Leiden University Medical Center, Leiden 2333 ZC, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Department of Human Genetics, Leiden University Medical Center, Leiden 2333 ZC, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Droit, Arnaud" sort="Droit, Arnaud" uniqKey="Droit A" first="Arnaud" last="Droit">Arnaud Droit</name><affiliation><nlm:aff id="A38">Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City G1V 4G2, Canada</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dork">Thilo Dork</name><affiliation><nlm:aff id="A39">Gynaecology Research Unit, Hannover Medical School, Hannover 30625, Germany</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A11">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A40">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA 90095, USA</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A41">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="A42">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation><nlm:aff id="A43">Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", 153 10 Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name><affiliation><nlm:aff id="A44">International Agency for Research on Cancer, Lyon 69372, France</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="A41">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A45">Division of Genetics and Epidemiology, Institute of Cancer Research, London SW7 3RP, UK</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A4">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria 3053, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Victoria 3053, Australia</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guenel">Pascal Guenel</name><affiliation><nlm:aff id="A47">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif 94807, France</nlm:aff></affiliation><affiliation><nlm:aff id="A48">University Paris-Sud, Villejuif 94807, France</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A49">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A50">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation><nlm:aff id="A51">Saw Swee Hock School of Public Health, National University of Singapore, Singapore 119077, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Department of Surgery, National University Health System, Singapore 117597</nlm:aff></affiliation></author><author><name sortKey="Miao, Hui" sort="Miao, Hui" uniqKey="Miao H" first="Hui" last="Miao">Hui Miao</name><affiliation><nlm:aff id="A51">Saw Swee Hock School of Public Health, National University of Singapore, Singapore 119077, Singapore</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="A53">Department of Medical Oncology, Erasmus MC Cancer Institute, 3015 CN Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A54">Division of Gynaecology and Obstetrics, Technische Universität München, Munich 81675, Germany</nlm:aff></affiliation></author><author><name sortKey="Hsiung, Chia Ni" sort="Hsiung, Chia Ni" uniqKey="Hsiung C" first="Chia-Ni" last="Hsiung">Chia-Ni Hsiung</name><affiliation><nlm:aff id="A55">Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name><affiliation><nlm:aff id="A57">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi 464-8681, Japan</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A58">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="A41">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation><nlm:aff id="A50">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota 12362, Colombi</nlm:aff></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation><nlm:aff id="A50">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="A30">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, FI-00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation><nlm:aff id="A61">Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, FI-00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="A62">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, M5S 1A8, Canada</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A64">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finlan</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio 70210, Finland</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A66">Vesalius Research Center, Leuven 3000, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven 3000, Belgium</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="A35">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="A68">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE-17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="A69">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A58">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A64">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finlan</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio 70210, Finland</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A70">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan 20133, Italy</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="A71">University of Hawaii Cancer Center, Honolulu, HI 96813, USA</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="A72">Department of Oncology - Pathology, Karolinska Institutet, Stockholm SE-17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="A73">National Center for Tumor Diseases, University of Heidelberg, Heidelberg 69120, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:aff id="A75">Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="A76">Anatomical Pathology, The Alfred Hospital, Melbourne, , Victoria 3004, Australia</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A54">Division of Gynaecology and Obstetrics, Technische Universität München, Munich 81675, Germany</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="A69">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Institute of Population Health, University of Manchester, Manchester M13 9PL, UK</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A78">Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A61">Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, FI-00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Nord, Silje" sort="Nord, Silje" uniqKey="Nord S" first="Silje" last="Nord">Silje Nord</name><affiliation><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen 70, N-0310 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A80">K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name><affiliation><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen 70, N-0310 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A80">K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="A81">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="A82">Division of Breast Cancer Research, Institute of Cancer Research, London, UK; Cancer Research, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name><affiliation><nlm:aff id="A83">Department of Clinical Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A84">IFOM, the FIRC Institute of Molecular Oncology, Milan 20139, Italy</nlm:aff></affiliation></author><author><name sortKey="Putti, Thomas Choudary" sort="Putti, Thomas Choudary" uniqKey="Putti T" first="Thomas Choudary" last="Putti">Thomas Choudary Putti</name><affiliation><nlm:aff id="A85">Department of Pathology, National University Health System, Singapore 117597</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A29">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="A86">National Cancer Institute, Bangkok 10400, Thailand</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="A87">Research Oncology, Guy’s Hospital, King's College London, London SE1 9RT, UK</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A24">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam 1066 CX, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A88">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne 50931, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Center for Integrated Oncology, University Hospital of Cologne, Cologne 50931, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Center for Molecular Medicine, University Hospital of Cologne, Cologne 50931, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne 50931, Germany</nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="A92">School of Public Health, China Medical University, Taichung 404, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hou, Ming Feng" sort="Hou, Ming Feng" uniqKey="Hou M" first="Ming-Feng" last="Hou">Ming-Feng Hou</name><affiliation><nlm:aff id="A94">Cancer Center and Department of Surgery, Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Matha J" sort="Shrubsole, Matha J" uniqKey="Shrubsole M" first="Matha J" last="Shrubsole">Matha J. Shrubsole</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A95">Department of Pathology, The University of Melbourne, Melbourne, Victoria 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="A96">Division of Genetics and Epidemiology and Division of Breast Cancer Research, Institute of Cancer Research, London SW7 3RP, UK</nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo Hwang" last="Teo">Soo Hwang Teo</name><affiliation><nlm:aff id="A97">Cancer Research Initiatives Foundation, 47500 Subang Jaya, Selangor, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="A98">Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, 59100 KualaLumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Thienpont, Bernard" sort="Thienpont, Bernard" uniqKey="Thienpont B" first="Bernard" last="Thienpont">Bernard Thienpont</name><affiliation><nlm:aff id="A66">Vesalius Research Center, Leuven 3000, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven 3000, Belgium</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="A99">Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="A100">Department of Surgical Oncology, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="A101">Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Therese" last="Truong">Therese Truong</name><affiliation><nlm:aff id="A47">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif 94807, France</nlm:aff></affiliation><affiliation><nlm:aff id="A48">University Paris-Sud, Villejuif 94807, France</nlm:aff></affiliation></author><author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name><affiliation><nlm:aff id="A49">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Wen, Wanqing" sort="Wen, Wanqing" uniqKey="Wen W" first="Wanqing" last="Wen">Wanqing Wen</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A102">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry, University of Oulu, Oulu FI-90220, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A103">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu FI-90220, Finland</nlm:aff></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H." last="Wu">Anna H. Wu</name><affiliation><nlm:aff id="A49">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng Har" last="Yip">Cheng Har Yip</name><affiliation><nlm:aff id="A98">Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, 59100 KualaLumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Zamora, Pilar M" sort="Zamora, Pilar M" uniqKey="Zamora P" first="Pilar M." last="Zamora">Pilar M. Zamora</name><affiliation><nlm:aff id="A104">Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid 28046, Spain</nlm:aff></affiliation></author><author><name sortKey="Zheng, Ying" sort="Zheng, Ying" uniqKey="Zheng Y" first="Ying" last="Zheng">Ying Zheng</name><affiliation><nlm:aff id="A105">Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, PR China</nlm:aff></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation><nlm:aff id="A106">University Hospital Gashuisberg, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name><affiliation><nlm:aff id="A107">Singapore Eye Research Institute, National University of Singapore, Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="A53">Department of Medical Oncology, Erasmus MC Cancer Institute, 3015 CN Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation><nlm:aff id="A53">Department of Medical Oncology, Erasmus MC Cancer Institute, 3015 CN Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="A53">Department of Medical Oncology, Erasmus MC Cancer Institute, 3015 CN Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela N" sort="Kristensen, Vessela N" uniqKey="Kristensen V" first="Vessela N." last="Kristensen">Vessela N. Kristensen</name><affiliation><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen 70, N-0310 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A80">K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A108">Department of Clinical Molecular Biology (EpiGen), Akershus University Hospital, University of Oslo (UiO), Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A35">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A38">Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City G1V 4G2, Canada</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A6">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Peter MacCallum Cancer Centre, The University of Melbourne, East Melbourne, VIC 3002, Australi</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27087578</idno><idno type="pmc">5110427</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110427</idno><idno type="RBID">PMC:5110427</idno><idno type="doi">10.1002/ijc.30150</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001C59</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C59</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer</title><author><name sortKey="Shi, Jiajun" sort="Shi, Jiajun" uniqKey="Shi J" first="Jiajun" last="Shi">Jiajun Shi</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Zhang, Yanfeng" sort="Zhang, Yanfeng" uniqKey="Zhang Y" first="Yanfeng" last="Zhang">Yanfeng Zhang</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Lush, Michael" sort="Lush, Michael" uniqKey="Lush M" first="Michael" last="Lush">Michael Lush</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A4">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria 3053, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Victoria 3053, Australia</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A6">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Kar, Siddhartha" sort="Kar, Siddhartha" uniqKey="Kar S" first="Siddhartha" last="Kar">Siddhartha Kar</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A7">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A9">Department of Epidemiology, University of California Irvine, Irvine, CA 92697, USA</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A10">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A11">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany</nlm:aff></affiliation></author><author><name sortKey="Zhao, Zhiguo" sort="Zhao, Zhiguo" uniqKey="Zhao Z" first="Zhiguo" last="Zhao">Zhiguo Zhao</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Guo, Xingyi" sort="Guo, Xingyi" uniqKey="Guo X" first="Xingyi" last="Guo">Xingyi Guo</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A12">Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid 28029, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Beeghly Fadiel, Alicia" sort="Beeghly Fadiel, Alicia" uniqKey="Beeghly Fadiel A" first="Alicia" last="Beeghly-Fadiel">Alicia Beeghly-Fadiel</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Blot, William" sort="Blot, William" uniqKey="Blot W" first="William" last="Blot">William Blot</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A14">International Epidemiology Institute, Rockville, MD 20850, USA</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="A15">Department of Radiation Oncology, Hannover Medical School, Hannover 30625, Germany</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A16">Copenhagen General Population Study, Herlev Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A19">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart 70376, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A20">University of Tübingen, Tübingen 72074, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A21">German Cancer Consortium, German Cancer Research Center(DKFZ), Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A10">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg 69120, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A21">German Cancer Consortium, German Cancer Research Center(DKFZ), Heidelberg 69120, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name><affiliation><nlm:aff id="A23">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="A24">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam 1066 CX, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="A25">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Bochum 44789, Germany</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="A26">Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg 69120, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Molecular Epidemiology Group, German Cancer Research Center, Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Cai, Hui" sort="Cai, Hui" uniqKey="Cai H" first="Hui" last="Cai">Hui Cai</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Canisius, Sander" sort="Canisius, Sander" uniqKey="Canisius S" first="Sander" last="Canisius">Sander Canisius</name><affiliation><nlm:aff id="A28">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A29">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name><affiliation><nlm:aff id="A30">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A32">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A33">Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="A34">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A35">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="A35">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="A36">Separtment of Pathology, Leiden University Medical Center, Leiden 2333 ZC, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Department of Human Genetics, Leiden University Medical Center, Leiden 2333 ZC, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Droit, Arnaud" sort="Droit, Arnaud" uniqKey="Droit A" first="Arnaud" last="Droit">Arnaud Droit</name><affiliation><nlm:aff id="A38">Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City G1V 4G2, Canada</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dork">Thilo Dork</name><affiliation><nlm:aff id="A39">Gynaecology Research Unit, Hannover Medical School, Hannover 30625, Germany</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A11">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A40">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA 90095, USA</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A41">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="A42">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation><nlm:aff id="A43">Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", 153 10 Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name><affiliation><nlm:aff id="A44">International Agency for Research on Cancer, Lyon 69372, France</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="A41">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A45">Division of Genetics and Epidemiology, Institute of Cancer Research, London SW7 3RP, UK</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A4">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria 3053, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Victoria 3053, Australia</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guenel">Pascal Guenel</name><affiliation><nlm:aff id="A47">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif 94807, France</nlm:aff></affiliation><affiliation><nlm:aff id="A48">University Paris-Sud, Villejuif 94807, France</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A49">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A50">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation><nlm:aff id="A51">Saw Swee Hock School of Public Health, National University of Singapore, Singapore 119077, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Department of Surgery, National University Health System, Singapore 117597</nlm:aff></affiliation></author><author><name sortKey="Miao, Hui" sort="Miao, Hui" uniqKey="Miao H" first="Hui" last="Miao">Hui Miao</name><affiliation><nlm:aff id="A51">Saw Swee Hock School of Public Health, National University of Singapore, Singapore 119077, Singapore</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="A53">Department of Medical Oncology, Erasmus MC Cancer Institute, 3015 CN Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A54">Division of Gynaecology and Obstetrics, Technische Universität München, Munich 81675, Germany</nlm:aff></affiliation></author><author><name sortKey="Hsiung, Chia Ni" sort="Hsiung, Chia Ni" uniqKey="Hsiung C" first="Chia-Ni" last="Hsiung">Chia-Ni Hsiung</name><affiliation><nlm:aff id="A55">Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name><affiliation><nlm:aff id="A57">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi 464-8681, Japan</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A58">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="A41">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation><nlm:aff id="A50">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota 12362, Colombi</nlm:aff></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation><nlm:aff id="A50">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="A30">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, FI-00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation><nlm:aff id="A61">Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, FI-00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="A62">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, M5S 1A8, Canada</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A64">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finlan</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio 70210, Finland</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A66">Vesalius Research Center, Leuven 3000, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven 3000, Belgium</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="A35">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="A68">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE-17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="A69">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A58">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A64">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finlan</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio 70210, Finland</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A70">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan 20133, Italy</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="A71">University of Hawaii Cancer Center, Honolulu, HI 96813, USA</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="A72">Department of Oncology - Pathology, Karolinska Institutet, Stockholm SE-17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="A73">National Center for Tumor Diseases, University of Heidelberg, Heidelberg 69120, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:aff id="A75">Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="A76">Anatomical Pathology, The Alfred Hospital, Melbourne, , Victoria 3004, Australia</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A54">Division of Gynaecology and Obstetrics, Technische Universität München, Munich 81675, Germany</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="A69">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Institute of Population Health, University of Manchester, Manchester M13 9PL, UK</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A78">Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A61">Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, FI-00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Nord, Silje" sort="Nord, Silje" uniqKey="Nord S" first="Silje" last="Nord">Silje Nord</name><affiliation><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen 70, N-0310 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A80">K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name><affiliation><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen 70, N-0310 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A80">K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="A81">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="A82">Division of Breast Cancer Research, Institute of Cancer Research, London, UK; Cancer Research, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name><affiliation><nlm:aff id="A83">Department of Clinical Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A84">IFOM, the FIRC Institute of Molecular Oncology, Milan 20139, Italy</nlm:aff></affiliation></author><author><name sortKey="Putti, Thomas Choudary" sort="Putti, Thomas Choudary" uniqKey="Putti T" first="Thomas Choudary" last="Putti">Thomas Choudary Putti</name><affiliation><nlm:aff id="A85">Department of Pathology, National University Health System, Singapore 117597</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A29">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg 69120, Germany</nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="A86">National Cancer Institute, Bangkok 10400, Thailand</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="A87">Research Oncology, Guy’s Hospital, King's College London, London SE1 9RT, UK</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A24">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam 1066 CX, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A88">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne 50931, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Center for Integrated Oncology, University Hospital of Cologne, Cologne 50931, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Center for Molecular Medicine, University Hospital of Cologne, Cologne 50931, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne 50931, Germany</nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="A92">School of Public Health, China Medical University, Taichung 404, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hou, Ming Feng" sort="Hou, Ming Feng" uniqKey="Hou M" first="Ming-Feng" last="Hou">Ming-Feng Hou</name><affiliation><nlm:aff id="A94">Cancer Center and Department of Surgery, Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Matha J" sort="Shrubsole, Matha J" uniqKey="Shrubsole M" first="Matha J" last="Shrubsole">Matha J. Shrubsole</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A95">Department of Pathology, The University of Melbourne, Melbourne, Victoria 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="A96">Division of Genetics and Epidemiology and Division of Breast Cancer Research, Institute of Cancer Research, London SW7 3RP, UK</nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo Hwang" last="Teo">Soo Hwang Teo</name><affiliation><nlm:aff id="A97">Cancer Research Initiatives Foundation, 47500 Subang Jaya, Selangor, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="A98">Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, 59100 KualaLumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Thienpont, Bernard" sort="Thienpont, Bernard" uniqKey="Thienpont B" first="Bernard" last="Thienpont">Bernard Thienpont</name><affiliation><nlm:aff id="A66">Vesalius Research Center, Leuven 3000, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven 3000, Belgium</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="A99">Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="A100">Department of Surgical Oncology, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="A101">Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Therese" last="Truong">Therese Truong</name><affiliation><nlm:aff id="A47">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif 94807, France</nlm:aff></affiliation><affiliation><nlm:aff id="A48">University Paris-Sud, Villejuif 94807, France</nlm:aff></affiliation></author><author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name><affiliation><nlm:aff id="A49">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Wen, Wanqing" sort="Wen, Wanqing" uniqKey="Wen W" first="Wanqing" last="Wen">Wanqing Wen</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A102">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry, University of Oulu, Oulu FI-90220, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A103">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu FI-90220, Finland</nlm:aff></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H." last="Wu">Anna H. Wu</name><affiliation><nlm:aff id="A49">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng Har" last="Yip">Cheng Har Yip</name><affiliation><nlm:aff id="A98">Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, 59100 KualaLumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Zamora, Pilar M" sort="Zamora, Pilar M" uniqKey="Zamora P" first="Pilar M." last="Zamora">Pilar M. Zamora</name><affiliation><nlm:aff id="A104">Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid 28046, Spain</nlm:aff></affiliation></author><author><name sortKey="Zheng, Ying" sort="Zheng, Ying" uniqKey="Zheng Y" first="Ying" last="Zheng">Ying Zheng</name><affiliation><nlm:aff id="A105">Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, PR China</nlm:aff></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation><nlm:aff id="A106">University Hospital Gashuisberg, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name><affiliation><nlm:aff id="A107">Singapore Eye Research Institute, National University of Singapore, Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="A53">Department of Medical Oncology, Erasmus MC Cancer Institute, 3015 CN Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation><nlm:aff id="A53">Department of Medical Oncology, Erasmus MC Cancer Institute, 3015 CN Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="A53">Department of Medical Oncology, Erasmus MC Cancer Institute, 3015 CN Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela N" sort="Kristensen, Vessela N" uniqKey="Kristensen V" first="Vessela N." last="Kristensen">Vessela N. Kristensen</name><affiliation><nlm:aff id="A79">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen 70, N-0310 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A80">K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A108">Department of Clinical Molecular Biology (EpiGen), Akershus University Hospital, University of Oslo (UiO), Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A35">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A38">Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City G1V 4G2, Canada</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A6">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Peter MacCallum Cancer Centre, The University of Melbourne, East Melbourne, VIC 3002, Australi</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author></analytic><series><title level="j">International journal of cancer</title><idno type="ISSN">0020-7136</idno><idno type="eISSN">1097-0215</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Previous genome-wide association studies among women of European ancestry identified two independent breast cancer susceptibility loci represented by single nucleotide polymorphisms (SNPs) rs13281615 and rs11780156 at 8q24. We conducted a fine-mapping study across 2.06 Mb (chr8:127,561,724 −129,624,067, hg19) in 55,540 breast cancer cases and 51,168 controls within the Breast Cancer Association Consortium. We found three additional independent association signals in women of European ancestry, represented by rs35961416 (OR = 0.95, 95% CI = 0.93-0.97, conditional <italic>P</italic> = 5.8 × 10<sup>−6</sup>), rs7815245 (OR = 0.94, 95% CI = 0.91-0.96, conditional <italic>P</italic> = 1.1 × 10<sup>−6</sup>), and rs2033101 (OR = 1.05, 95% CI = 1.02-1.07, conditional <italic>P</italic> = 1.1 × 10<sup>−4</sup>). Integrative analysis using functional genomic data from the Roadmap Epigenomics, the Encyclopedia of DNA Elements project, the Cancer Genome Atlas, and other public resources implied that SNPs rs7815245 in Signal 3, and rs1121948 in Signal 5 (in linkage disequilibrium with rs11780156, r<sup>2</sup> = 0.77), were putatively functional variants for two of the five independent association signals. Our results highlight multiple 8q24 variants associated with breast cancer susceptibility in women of European ancestry.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0042124</journal-id><journal-id journal-id-type="pubmed-jr-id">4284</journal-id><journal-id journal-id-type="nlm-ta">Int J Cancer</journal-id><journal-id journal-id-type="iso-abbrev">Int. J. Cancer</journal-id><journal-title-group><journal-title>International journal of cancer</journal-title></journal-title-group><issn pub-type="ppub">0020-7136</issn><issn pub-type="epub">1097-0215</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27087578</article-id><article-id pub-id-type="pmc">5110427</article-id><article-id pub-id-type="doi">10.1002/ijc.30150</article-id><article-id pub-id-type="manuscript">NIHMS827493</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Shi</surname><given-names>Jiajun</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Zhang</surname><given-names>Yanfeng</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Wei</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Michailidou</surname><given-names>Kyriaki</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ghoussaini</surname><given-names>Maya</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Bolla</surname><given-names>Manjeet K.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Qin</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Dennis</surname><given-names>Joe</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Lush</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Milne</surname><given-names>Roger L.</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Shu</surname><given-names>Xiao-Ou</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Beesley</surname><given-names>Jonathan</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Kar</surname><given-names>Siddhartha</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Andrulis</surname><given-names>Irene L.</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Anton-Culver</surname><given-names>Hoda</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Arndt</surname><given-names>Volker</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Beckmann</surname><given-names>Matthias W.</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Zhiguo</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Guo</surname><given-names>Xingyi</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Benitez</surname><given-names>Javier</given-names></name><xref ref-type="aff" rid="A12">12</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Beeghly-Fadiel</surname><given-names>Alicia</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Blot</surname><given-names>William</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Bogdanova</surname><given-names>Natalia V.</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Bojesen</surname><given-names>Stig E.</given-names></name><xref ref-type="aff" rid="A16">16</xref><xref ref-type="aff" rid="A17">17</xref><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Brauch</surname><given-names>Hiltrud</given-names></name><xref ref-type="aff" rid="A19">19</xref><xref ref-type="aff" rid="A20">20</xref><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Brenner</surname><given-names>Hermann</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A21">21</xref><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Brinton</surname><given-names>Louise</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Broeks</surname><given-names>Annegien</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Brüning</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Burwinkel</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="A26">26</xref><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Cai</surname><given-names>Hui</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Canisius</surname><given-names>Sander</given-names></name><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Choi</surname><given-names>Ji-Yeob</given-names></name><xref ref-type="aff" rid="A30">30</xref><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus J.</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Cox</surname><given-names>Angela</given-names></name><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Cross</surname><given-names>Simon S.</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Czene</surname><given-names>Kamila</given-names></name><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Darabi</surname><given-names>Hatef</given-names></name><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Devilee</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A36">36</xref><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Droit</surname><given-names>Arnaud</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Dork</surname><given-names>Thilo</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Fasching</surname><given-names>Peter A.</given-names></name><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Fletcher</surname><given-names>Olivia</given-names></name><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Flyger</surname><given-names>Henrik</given-names></name><xref ref-type="aff" rid="A42">42</xref></contrib><contrib contrib-type="author"><name><surname>Fostira</surname><given-names>Florentia</given-names></name><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Gaborieau</surname><given-names>Valerie</given-names></name><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>García-Closas</surname><given-names>Montserrat</given-names></name><xref ref-type="aff" rid="A41">41</xref><xref ref-type="aff" rid="A45">45</xref></contrib><contrib contrib-type="author"><name><surname>Giles</surname><given-names>Graham G.</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><collab>Mervi Grip</collab><xref ref-type="aff" rid="A46">46</xref></contrib><contrib contrib-type="author"><name><surname>Guenel</surname><given-names>Pascal</given-names></name><xref ref-type="aff" rid="A47">47</xref><xref ref-type="aff" rid="A48">48</xref></contrib><contrib contrib-type="author"><name><surname>Haiman</surname><given-names>Christopher A.</given-names></name><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name><xref ref-type="aff" rid="A50">50</xref></contrib><contrib contrib-type="author"><name><surname>Hartman</surname><given-names>Mikael</given-names></name><xref ref-type="aff" rid="A51">51</xref><xref ref-type="aff" rid="A52">52</xref></contrib><contrib contrib-type="author"><name><surname>Miao</surname><given-names>Hui</given-names></name><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Hollestelle</surname><given-names>Antoinette</given-names></name><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John L.</given-names></name><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Hsiung</surname><given-names>Chia-Ni</given-names></name><xref ref-type="aff" rid="A55">55</xref></contrib><contrib contrib-type="author"><collab>kConFab Investigators</collab><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Ito</surname><given-names>Hidemi</given-names></name><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Jakubowska</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="A58">58</xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Nichola</given-names></name><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Torres</surname><given-names>Diana</given-names></name><xref ref-type="aff" rid="A50">50</xref><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Kabisch</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="A50">50</xref></contrib><contrib contrib-type="author"><name><surname>Kang</surname><given-names>Daehee</given-names></name><xref ref-type="aff" rid="A30">30</xref><xref ref-type="aff" rid="A31">31</xref><xref ref-type="aff" rid="A61">61</xref></contrib><contrib contrib-type="author"><name><surname>Khan</surname><given-names>Sofia</given-names></name><xref ref-type="aff" rid="A61">61</xref></contrib><contrib contrib-type="author"><name><surname>Knight</surname><given-names>Julia A.</given-names></name><xref ref-type="aff" rid="A62">62</xref><xref ref-type="aff" rid="A63">63</xref></contrib><contrib contrib-type="author"><name><surname>Kosma</surname><given-names>Veli-Matti</given-names></name><xref ref-type="aff" rid="A64">64</xref><xref ref-type="aff" rid="A65">65</xref></contrib><contrib contrib-type="author"><name><surname>Lambrechts</surname><given-names>Diether</given-names></name><xref ref-type="aff" rid="A66">66</xref><xref ref-type="aff" rid="A67">67</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Jingmei</given-names></name><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Lindblom</surname><given-names>Annika</given-names></name><xref ref-type="aff" rid="A68">68</xref></contrib><contrib contrib-type="author"><name><surname>Lophatananon</surname><given-names>Artitaya</given-names></name><xref ref-type="aff" rid="A69">69</xref></contrib><contrib contrib-type="author"><name><surname>Lubinski</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="A58">58</xref></contrib><contrib contrib-type="author"><name><surname>Mannermaa</surname><given-names>Arto</given-names></name><xref ref-type="aff" rid="A64">64</xref><xref ref-type="aff" rid="A65">65</xref></contrib><contrib contrib-type="author"><name><surname>Manoukian</surname><given-names>Siranoush</given-names></name><xref ref-type="aff" rid="A70">70</xref></contrib><contrib contrib-type="author"><name><surname>Le Marchand</surname><given-names>Loic</given-names></name><xref ref-type="aff" rid="A71">71</xref></contrib><contrib contrib-type="author"><name><surname>Margolin</surname><given-names>Sara</given-names></name><xref ref-type="aff" rid="A72">72</xref></contrib><contrib contrib-type="author"><name><surname>Marme</surname><given-names>Frederik</given-names></name><xref ref-type="aff" rid="A73">73</xref><xref ref-type="aff" rid="A74">74</xref></contrib><contrib contrib-type="author"><name><surname>Matsuo</surname><given-names>Keitaro</given-names></name><xref ref-type="aff" rid="A75">75</xref></contrib><contrib contrib-type="author"><name><surname>McLean</surname><given-names>Catriona</given-names></name><xref ref-type="aff" rid="A76">76</xref></contrib><contrib contrib-type="author"><name><surname>Meindl</surname><given-names>Alfons</given-names></name><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Muir</surname><given-names>Kenneth</given-names></name><xref ref-type="aff" rid="A69">69</xref><xref ref-type="aff" rid="A77">77</xref></contrib><contrib contrib-type="author"><name><surname>Neuhausen</surname><given-names>Susan L.</given-names></name><xref ref-type="aff" rid="A78">78</xref></contrib><contrib contrib-type="author"><name><surname>Nevanlinna</surname><given-names>Heli</given-names></name><xref ref-type="aff" rid="A61">61</xref></contrib><contrib contrib-type="author"><name><surname>Nord</surname><given-names>Silje</given-names></name><xref ref-type="aff" rid="A79">79</xref><xref ref-type="aff" rid="A80">80</xref></contrib><contrib contrib-type="author"><name><surname>Børresen-Dale</surname><given-names>Anne-Lise</given-names></name><xref ref-type="aff" rid="A79">79</xref><xref ref-type="aff" rid="A80">80</xref></contrib><contrib contrib-type="author"><name><surname>Olson</surname><given-names>Janet E.</given-names></name><xref ref-type="aff" rid="A81">81</xref></contrib><contrib contrib-type="author"><name><surname>Orr</surname><given-names>Nick</given-names></name><xref ref-type="aff" rid="A82">82</xref></contrib><contrib contrib-type="author"><name><surname>van den Ouweland</surname><given-names>Ans M.W.</given-names></name><xref ref-type="aff" rid="A83">83</xref></contrib><contrib contrib-type="author"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="A84">84</xref></contrib><contrib contrib-type="author"><name><surname>Putti</surname><given-names>Thomas Choudary</given-names></name><xref ref-type="aff" rid="A85">85</xref></contrib><contrib contrib-type="author"><name><surname>Rudolph</surname><given-names>Anja</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Sangrajrang</surname><given-names>Suleeporn</given-names></name><xref ref-type="aff" rid="A86">86</xref></contrib><contrib contrib-type="author"><name><surname>Sawyer</surname><given-names>Elinor J.</given-names></name><xref ref-type="aff" rid="A87">87</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Marjanka K.</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Schmutzler</surname><given-names>Rita K.</given-names></name><xref ref-type="aff" rid="A88">88</xref><xref ref-type="aff" rid="A89">89</xref><xref ref-type="aff" rid="A90">90</xref><xref ref-type="aff" rid="A91">91</xref></contrib><contrib contrib-type="author"><name><surname>Shen</surname><given-names>Chen-Yang</given-names></name><xref ref-type="aff" rid="A92">92</xref><xref ref-type="aff" rid="A93">93</xref></contrib><contrib contrib-type="author"><name><surname>Hou</surname><given-names>Ming-Feng</given-names></name><xref ref-type="aff" rid="A94">94</xref></contrib><contrib contrib-type="author"><name><surname>Shrubsole</surname><given-names>Matha J</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Southey</surname><given-names>Melissa C.</given-names></name><xref ref-type="aff" rid="A95">95</xref></contrib><contrib contrib-type="author"><name><surname>Swerdlow</surname><given-names>Anthony</given-names></name><xref ref-type="aff" rid="A96">96</xref></contrib><contrib contrib-type="author"><name><surname>Teo</surname><given-names>Soo Hwang</given-names></name><xref ref-type="aff" rid="A97">97</xref><xref ref-type="aff" rid="A98">98</xref></contrib><contrib contrib-type="author"><name><surname>Thienpont</surname><given-names>Bernard</given-names></name><xref ref-type="aff" rid="A66">66</xref><xref ref-type="aff" rid="A67">67</xref></contrib><contrib contrib-type="author"><name><surname>Toland</surname><given-names>Amanda E.</given-names></name><xref ref-type="aff" rid="A99">99</xref></contrib><contrib contrib-type="author"><name><surname>Tollenaar</surname><given-names>Robert A.E.M.</given-names></name><xref ref-type="aff" rid="A100">100</xref></contrib><contrib contrib-type="author"><name><surname>Tomlinson</surname><given-names>Ian</given-names></name><xref ref-type="aff" rid="A101">101</xref></contrib><contrib contrib-type="author"><name><surname>Truong</surname><given-names>Therese</given-names></name><xref ref-type="aff" rid="A47">47</xref><xref ref-type="aff" rid="A48">48</xref></contrib><contrib contrib-type="author"><name><surname>Tseng</surname><given-names>Chiu-chen</given-names></name><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Wen</surname><given-names>Wanqing</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Winqvist</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="A102">102</xref><xref ref-type="aff" rid="A103">103</xref></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Anna H.</given-names></name><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Yip</surname><given-names>Cheng Har</given-names></name><xref ref-type="aff" rid="A98">98</xref></contrib><contrib contrib-type="author"><name><surname>Zamora</surname><given-names>Pilar M.</given-names></name><xref ref-type="aff" rid="A104">104</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Ying</given-names></name><xref ref-type="aff" rid="A105">105</xref></contrib><contrib contrib-type="author"><name><surname>Floris</surname><given-names>Giuseppe</given-names></name><xref ref-type="aff" rid="A106">106</xref></contrib><contrib contrib-type="author"><name><surname>Cheng</surname><given-names>Ching-Yu</given-names></name><xref ref-type="aff" rid="A107">107</xref></contrib><contrib contrib-type="author"><name><surname>Hooning</surname><given-names>Maartje J.</given-names></name><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Martens</surname><given-names>John W.M.</given-names></name><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Seynaeve</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Kristensen</surname><given-names>Vessela N.</given-names></name><xref ref-type="aff" rid="A79">79</xref><xref ref-type="aff" rid="A80">80</xref><xref ref-type="aff" rid="A108">108</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul D.P.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Simard</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Antoniou</surname><given-names>Antonis C.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Cai</surname><given-names>Qiuyin</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib><contrib contrib-type="author"><name><surname>Long</surname><given-names>Jirong</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</aff><aff id="A2"><label>2</label>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</aff><aff id="A3"><label>3</label>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</aff><aff id="A4"><label>4</label>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria 3053, Australia</aff><aff id="A5"><label>5</label>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Victoria 3053, Australia</aff><aff id="A6"><label>6</label>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</aff><aff id="A7"><label>7</label>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada</aff><aff id="A8"><label>8</label>Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada</aff><aff id="A9"><label>9</label>Department of Epidemiology, University of California Irvine, Irvine, CA 92697, USA</aff><aff id="A10"><label>10</label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg 69120, Germany</aff><aff id="A11"><label>11</label>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany</aff><aff id="A12"><label>12</label>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid 28029, Spain</aff><aff id="A13"><label>13</label>Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</aff><aff id="A14"><label>14</label>International Epidemiology Institute, Rockville, MD 20850, USA</aff><aff id="A15"><label>15</label>Department of Radiation Oncology, Hannover Medical School, Hannover 30625, Germany</aff><aff id="A16"><label>16</label>Copenhagen General Population Study, Herlev Hospital, 2730 Herlev, Denmark</aff><aff id="A17"><label>17</label>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</aff><aff id="A18"><label>18</label>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</aff><aff id="A19"><label>19</label>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart 70376, Germany</aff><aff id="A20"><label>20</label>University of Tübingen, Tübingen 72074, Germany</aff><aff id="A21"><label>21</label>German Cancer Consortium, German Cancer Research Center(DKFZ), Heidelberg 69120, Germany</aff><aff id="A22"><label>22</label>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany</aff><aff id="A23"><label>23</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA</aff><aff id="A24"><label>24</label>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam 1066 CX, The Netherlands</aff><aff id="A25"><label>25</label>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Bochum 44789, Germany</aff><aff id="A26"><label>26</label>Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg 69120, Germany</aff><aff id="A27"><label>27</label>Molecular Epidemiology Group, German Cancer Research Center, Heidelberg 69120, Germany</aff><aff id="A28"><label>28</label>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</aff><aff id="A29"><label>29</label>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg 69120, Germany</aff><aff id="A30"><label>30</label>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea</aff><aff id="A31"><label>31</label>Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea</aff><aff id="A32"><label>32</label>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</aff><aff id="A33"><label>33</label>Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK</aff><aff id="A34"><label>34</label>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK</aff><aff id="A35"><label>35</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden</aff><aff id="A36"><label>36</label>Separtment of Pathology, Leiden University Medical Center, Leiden 2333 ZC, The Netherlands</aff><aff id="A37"><label>37</label>Department of Human Genetics, Leiden University Medical Center, Leiden 2333 ZC, The Netherlands</aff><aff id="A38"><label>38</label>Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City G1V 4G2, Canada</aff><aff id="A39"><label>39</label>Gynaecology Research Unit, Hannover Medical School, Hannover 30625, Germany</aff><aff id="A40"><label>40</label>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA 90095, USA</aff><aff id="A41"><label>41</label>Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</aff><aff id="A42"><label>42</label>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</aff><aff id="A43"><label>43</label>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", 153 10 Athens, Greece</aff><aff id="A44"><label>44</label>International Agency for Research on Cancer, Lyon 69372, France</aff><aff id="A45"><label>45</label>Division of Genetics and Epidemiology, Institute of Cancer Research, London SW7 3RP, UK</aff><aff id="A46"><label>46</label>Department of Surgery, Oulu University Hospital and University of Oulu, Oulu FI-90220, Finland</aff><aff id="A47"><label>47</label>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif 94807, France</aff><aff id="A48"><label>48</label>University Paris-Sud, Villejuif 94807, France</aff><aff id="A49"><label>49</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</aff><aff id="A50"><label>50</label>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany</aff><aff id="A51"><label>51</label>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 119077, Singapore</aff><aff id="A52"><label>52</label>Department of Surgery, National University Health System, Singapore 117597</aff><aff id="A53"><label>53</label>Department of Medical Oncology, Erasmus MC Cancer Institute, 3015 CN Rotterdam, The Netherlands</aff><aff id="A54"><label>54</label>Division of Gynaecology and Obstetrics, Technische Universität München, Munich 81675, Germany</aff><aff id="A55"><label>55</label>Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</aff><aff id="A56"><label>56</label>Peter MacCallum Cancer Centre, The University of Melbourne, East Melbourne, VIC 3002, Australi</aff><aff id="A57"><label>57</label>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi 464-8681, Japan</aff><aff id="A58"><label>58</label>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland</aff><aff id="A59"><label>59</label>Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota 12362, Colombi</aff><aff id="A60"><label>60</label>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea</aff><aff id="A61"><label>61</label>Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, FI-00029 HUS, Finland</aff><aff id="A62"><label>62</label>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada</aff><aff id="A63"><label>63</label>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, M5S 1A8, Canada</aff><aff id="A64"><label>64</label>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finlan</aff><aff id="A65"><label>65</label>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio 70210, Finland</aff><aff id="A66"><label>66</label>Vesalius Research Center, Leuven 3000, Belgium</aff><aff id="A67"><label>67</label>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven 3000, Belgium</aff><aff id="A68"><label>68</label>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE-17177, Sweden</aff><aff id="A69"><label>69</label>Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK</aff><aff id="A70"><label>70</label>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan 20133, Italy</aff><aff id="A71"><label>71</label>University of Hawaii Cancer Center, Honolulu, HI 96813, USA</aff><aff id="A72"><label>72</label>Department of Oncology - Pathology, Karolinska Institutet, Stockholm SE-17177, Sweden</aff><aff id="A73"><label>73</label>National Center for Tumor Diseases, University of Heidelberg, Heidelberg 69120, Germany</aff><aff id="A74"><label>74</label>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg 69120, Germany</aff><aff id="A75"><label>75</label>Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan</aff><aff id="A76"><label>76</label>Anatomical Pathology, The Alfred Hospital, Melbourne, , Victoria 3004, Australia</aff><aff id="A77"><label>77</label>Institute of Population Health, University of Manchester, Manchester M13 9PL, UK</aff><aff id="A78"><label>78</label>Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</aff><aff id="A79"><label>79</label>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen 70, N-0310 Oslo, Norway</aff><aff id="A80"><label>80</label>K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway</aff><aff id="A81"><label>81</label>Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</aff><aff id="A82"><label>82</label>Division of Breast Cancer Research, Institute of Cancer Research, London, UK; Cancer Research, Institute of Cancer Research, London SW3 6JB, UK</aff><aff id="A83"><label>83</label>Department of Clinical Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands</aff><aff id="A84"><label>84</label>IFOM, the FIRC Institute of Molecular Oncology, Milan 20139, Italy</aff><aff id="A85"><label>85</label>Department of Pathology, National University Health System, Singapore 117597</aff><aff id="A86"><label>86</label>National Cancer Institute, Bangkok 10400, Thailand</aff><aff id="A87"><label>87</label>Research Oncology, Guy’s Hospital, King's College London, London SE1 9RT, UK</aff><aff id="A88"><label>88</label>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne 50931, Germany</aff><aff id="A89"><label>89</label>Center for Integrated Oncology, University Hospital of Cologne, Cologne 50931, Germany</aff><aff id="A90"><label>90</label>Center for Molecular Medicine, University Hospital of Cologne, Cologne 50931, Germany</aff><aff id="A91"><label>91</label>Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne 50931, Germany</aff><aff id="A92"><label>92</label>School of Public Health, China Medical University, Taichung 404, Taiwan</aff><aff id="A93"><label>93</label>Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</aff><aff id="A94"><label>94</label>Cancer Center and Department of Surgery, Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan</aff><aff id="A95"><label>95</label>Department of Pathology, The University of Melbourne, Melbourne, Victoria 3010, Australia</aff><aff id="A96"><label>96</label>Division of Genetics and Epidemiology and Division of Breast Cancer Research, Institute of Cancer Research, London SW7 3RP, UK</aff><aff id="A97"><label>97</label>Cancer Research Initiatives Foundation, 47500 Subang Jaya, Selangor, Malaysia</aff><aff id="A98"><label>98</label>Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, 59100 KualaLumpur, Malaysia</aff><aff id="A99"><label>99</label>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA</aff><aff id="A100"><label>100</label>Department of Surgical Oncology, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands</aff><aff id="A101"><label>101</label>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK</aff><aff id="A102"><label>102</label>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry, University of Oulu, Oulu FI-90220, Finland</aff><aff id="A103"><label>103</label>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu FI-90220, Finland</aff><aff id="A104"><label>104</label>Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid 28046, Spain</aff><aff id="A105"><label>105</label>Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, PR China</aff><aff id="A106"><label>106</label>University Hospital Gashuisberg, Leuven, Belgium</aff><aff id="A107"><label>107</label>Singapore Eye Research Institute, National University of Singapore, Singapore, Singapore</aff><aff id="A108"><label>108</label>Department of Clinical Molecular Biology (EpiGen), Akershus University Hospital, University of Oslo (UiO), Oslo, Norway</aff><author-notes><corresp id="CR1"><label>*</label><bold>Correspondence to:</bold> Jirong Long, PhD, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 2525 West End Avenue, 8th Floor, Nashville, TN 37203, Phone: (615) 343-6741; Fax: (615) 936-8241, <email>Jirong.Long@vanderbilt.edu</email>, Qiuyin Cai, M.D., Ph.D., Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN 37232, Phone: (615) 936-1351; Fax: (615)936-8291, <email>qiuyin.cai@vanderbilt.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>5</day><month>11</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>17</day><month>6</month><year>2016</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>9</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>9</month><year>2017</year></pub-date><volume>139</volume><issue>6</issue><fpage>1303</fpage><lpage>1317</lpage><pmc-comment>elocation-id from pubmed: 10.1002/ijc.30150</pmc-comment>
<abstract><p id="P1">Previous genome-wide association studies among women of European ancestry identified two independent breast cancer susceptibility loci represented by single nucleotide polymorphisms (SNPs) rs13281615 and rs11780156 at 8q24. We conducted a fine-mapping study across 2.06 Mb (chr8:127,561,724 −129,624,067, hg19) in 55,540 breast cancer cases and 51,168 controls within the Breast Cancer Association Consortium. We found three additional independent association signals in women of European ancestry, represented by rs35961416 (OR = 0.95, 95% CI = 0.93-0.97, conditional <italic>P</italic> = 5.8 × 10<sup>−6</sup>), rs7815245 (OR = 0.94, 95% CI = 0.91-0.96, conditional <italic>P</italic> = 1.1 × 10<sup>−6</sup>), and rs2033101 (OR = 1.05, 95% CI = 1.02-1.07, conditional <italic>P</italic> = 1.1 × 10<sup>−4</sup>). Integrative analysis using functional genomic data from the Roadmap Epigenomics, the Encyclopedia of DNA Elements project, the Cancer Genome Atlas, and other public resources implied that SNPs rs7815245 in Signal 3, and rs1121948 in Signal 5 (in linkage disequilibrium with rs11780156, r<sup>2</sup> = 0.77), were putatively functional variants for two of the five independent association signals. Our results highlight multiple 8q24 variants associated with breast cancer susceptibility in women of European ancestry.</p></abstract><kwd-group><kwd>breast cancer</kwd><kwd>genetic susceptibility</kwd><kwd>8q24</kwd><kwd>fine-mapping</kwd><kwd>single nucleotide polymorphism</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C59 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001C59 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé= PMC:5110427
|texte= Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:27087578" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |