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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parental occupational pesticide exposure and the risk of childhood leukemia
in the offspring: Findings from the Childhood Leukemia International
Consortium</title><author><name sortKey="Bailey, Helen D" sort="Bailey, Helen D" uniqKey="Bailey H" first="Helen D" last="Bailey">Helen D. Bailey</name><affiliation><nlm:aff id="A1">International Agency for Research on Cancer (IARC), Section of Environment and Radiation, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France</nlm:aff></affiliation></author><author><name sortKey="Fritschi, Lin" sort="Fritschi, Lin" uniqKey="Fritschi L" first="Lin" last="Fritschi">Lin Fritschi</name><affiliation><nlm:aff id="A2">Curtin University, School of Public Health, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="Infante Rivard, Claire" sort="Infante Rivard, Claire" uniqKey="Infante Rivard C" first="Claire" last="Infante-Rivard">Claire Infante-Rivard</name><affiliation><nlm:aff id="A3">Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine, McGill University, Canada</nlm:aff></affiliation></author><author><name sortKey="Glass, Deborah C" sort="Glass, Deborah C" uniqKey="Glass D" first="Deborah C" last="Glass">Deborah C. Glass</name><affiliation><nlm:aff id="A4">Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Miligi, Lucia" sort="Miligi, Lucia" uniqKey="Miligi L" first="Lucia" last="Miligi">Lucia Miligi</name><affiliation><nlm:aff id="A5">ISPO-Cancer Prevention and Research Institute, Occupational and Environmental Epidemiology Unit, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Dockerty, John D" sort="Dockerty, John D" uniqKey="Dockerty J" first="John D" last="Dockerty">John D. Dockerty</name><affiliation><nlm:aff id="A6">Dean's Department and Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand</nlm:aff></affiliation></author><author><name sortKey="Lightfoot, Tracy" sort="Lightfoot, Tracy" uniqKey="Lightfoot T" first="Tracy" last="Lightfoot">Tracy Lightfoot</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name><affiliation><nlm:aff id="A8">Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Roman, Eve" sort="Roman, Eve" uniqKey="Roman E" first="Eve" last="Roman">Eve Roman</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Spector, Logan G" sort="Spector, Logan G" uniqKey="Spector L" first="Logan G" last="Spector">Logan G. Spector</name><affiliation><nlm:aff id="A9">Division of Epidemiology Clinical Research, Department of Pediatrics and Masonic Cancer Center, University of Minnesota, Minneapolis, United States</nlm:aff></affiliation></author><author><name sortKey="Kaatsch, Peter" sort="Kaatsch, Peter" uniqKey="Kaatsch P" first="Peter" last="Kaatsch">Peter Kaatsch</name><affiliation><nlm:aff id="A10">German Childhood Cancer Registry (GCCR) at the Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz, Germany</nlm:aff></affiliation></author><author><name sortKey="Metayer, Catherine" sort="Metayer, Catherine" uniqKey="Metayer C" first="Catherine" last="Metayer">Catherine Metayer</name><affiliation><nlm:aff id="A11">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff></affiliation></author><author><name sortKey="Magnani, Corrado" sort="Magnani, Corrado" uniqKey="Magnani C" first="Corrado" last="Magnani">Corrado Magnani</name><affiliation><nlm:aff id="A12">Dipartimento di Medicina Traslazionale – Universita` del Piemonte Orientale, AOU Maggiore della Carita` e CPO – Piemonte, Novara, Italy</nlm:aff></affiliation></author><author><name sortKey="Milne, Elizabeth" sort="Milne, Elizabeth" uniqKey="Milne E" first="Elizabeth" last="Milne">Elizabeth Milne</name><affiliation><nlm:aff id="A13">Telethon Kids Institute, the University of Western Australia, Perth Australia</nlm:aff></affiliation></author><author><name sortKey="Polychronopoulou, Sophia" sort="Polychronopoulou, Sophia" uniqKey="Polychronopoulou S" first="Sophia" last="Polychronopoulou">Sophia Polychronopoulou</name><affiliation><nlm:aff id="A14">Department of Pediatric Hematology-Oncology, Athens University Medical School, ‘Aghia Sophia’ General Children’s Hospital, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Simpson, Jill" sort="Simpson, Jill" uniqKey="Simpson J" first="Jill" last="Simpson">Jill Simpson</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Rudant, Jeremie" sort="Rudant, Jeremie" uniqKey="Rudant J" first="Jérémie" last="Rudant">Jérémie Rudant</name><affiliation><nlm:aff id="A8">Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Sidi, Vasiliki" sort="Sidi, Vasiliki" uniqKey="Sidi V" first="Vasiliki" last="Sidi">Vasiliki Sidi</name><affiliation><nlm:aff id="A15">Department of Pediatric Hematology-Oncology, Ippokrateion Hospital, Salonica, Greece</nlm:aff></affiliation></author><author><name sortKey="Rondelli, Roberto" sort="Rondelli, Roberto" uniqKey="Rondelli R" first="Roberto" last="Rondelli">Roberto Rondelli</name><affiliation><nlm:aff id="A16">Paediatric Haematology -Oncology, Lalla Seràgnoli, Policlinico Sant’Orsola Malpighi Bologna Italy</nlm:aff></affiliation></author><author><name sortKey="Orsi, Laurent" sort="Orsi, Laurent" uniqKey="Orsi L" first="Laurent" last="Orsi">Laurent Orsi</name><affiliation><nlm:aff id="A8">Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Kang, Alice" sort="Kang, Alice" uniqKey="Kang A" first="Alice" last="Kang">Alice Kang</name><affiliation><nlm:aff id="A11">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff></affiliation></author><author><name sortKey="Petridou, Eleni" sort="Petridou, Eleni" uniqKey="Petridou E" first="Eleni" last="Petridou">Eleni Petridou</name><affiliation><nlm:aff id="A17">Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Medical School, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Schuz, Joachim" sort="Schuz, Joachim" uniqKey="Schuz J" first="Joachim" last="Schüz">Joachim Schüz</name><affiliation><nlm:aff id="A1">International Agency for Research on Cancer (IARC), Section of Environment and Radiation, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24700406</idno><idno type="pmc">4845098</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845098</idno><idno type="RBID">PMC:4845098</idno><idno type="doi">10.1002/ijc.28854</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001C57</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C57</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Parental occupational pesticide exposure and the risk of childhood leukemia
in the offspring: Findings from the Childhood Leukemia International
Consortium</title><author><name sortKey="Bailey, Helen D" sort="Bailey, Helen D" uniqKey="Bailey H" first="Helen D" last="Bailey">Helen D. Bailey</name><affiliation><nlm:aff id="A1">International Agency for Research on Cancer (IARC), Section of Environment and Radiation, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France</nlm:aff></affiliation></author><author><name sortKey="Fritschi, Lin" sort="Fritschi, Lin" uniqKey="Fritschi L" first="Lin" last="Fritschi">Lin Fritschi</name><affiliation><nlm:aff id="A2">Curtin University, School of Public Health, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="Infante Rivard, Claire" sort="Infante Rivard, Claire" uniqKey="Infante Rivard C" first="Claire" last="Infante-Rivard">Claire Infante-Rivard</name><affiliation><nlm:aff id="A3">Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine, McGill University, Canada</nlm:aff></affiliation></author><author><name sortKey="Glass, Deborah C" sort="Glass, Deborah C" uniqKey="Glass D" first="Deborah C" last="Glass">Deborah C. Glass</name><affiliation><nlm:aff id="A4">Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Miligi, Lucia" sort="Miligi, Lucia" uniqKey="Miligi L" first="Lucia" last="Miligi">Lucia Miligi</name><affiliation><nlm:aff id="A5">ISPO-Cancer Prevention and Research Institute, Occupational and Environmental Epidemiology Unit, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Dockerty, John D" sort="Dockerty, John D" uniqKey="Dockerty J" first="John D" last="Dockerty">John D. Dockerty</name><affiliation><nlm:aff id="A6">Dean's Department and Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand</nlm:aff></affiliation></author><author><name sortKey="Lightfoot, Tracy" sort="Lightfoot, Tracy" uniqKey="Lightfoot T" first="Tracy" last="Lightfoot">Tracy Lightfoot</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name><affiliation><nlm:aff id="A8">Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Roman, Eve" sort="Roman, Eve" uniqKey="Roman E" first="Eve" last="Roman">Eve Roman</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Spector, Logan G" sort="Spector, Logan G" uniqKey="Spector L" first="Logan G" last="Spector">Logan G. Spector</name><affiliation><nlm:aff id="A9">Division of Epidemiology Clinical Research, Department of Pediatrics and Masonic Cancer Center, University of Minnesota, Minneapolis, United States</nlm:aff></affiliation></author><author><name sortKey="Kaatsch, Peter" sort="Kaatsch, Peter" uniqKey="Kaatsch P" first="Peter" last="Kaatsch">Peter Kaatsch</name><affiliation><nlm:aff id="A10">German Childhood Cancer Registry (GCCR) at the Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz, Germany</nlm:aff></affiliation></author><author><name sortKey="Metayer, Catherine" sort="Metayer, Catherine" uniqKey="Metayer C" first="Catherine" last="Metayer">Catherine Metayer</name><affiliation><nlm:aff id="A11">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff></affiliation></author><author><name sortKey="Magnani, Corrado" sort="Magnani, Corrado" uniqKey="Magnani C" first="Corrado" last="Magnani">Corrado Magnani</name><affiliation><nlm:aff id="A12">Dipartimento di Medicina Traslazionale – Universita` del Piemonte Orientale, AOU Maggiore della Carita` e CPO – Piemonte, Novara, Italy</nlm:aff></affiliation></author><author><name sortKey="Milne, Elizabeth" sort="Milne, Elizabeth" uniqKey="Milne E" first="Elizabeth" last="Milne">Elizabeth Milne</name><affiliation><nlm:aff id="A13">Telethon Kids Institute, the University of Western Australia, Perth Australia</nlm:aff></affiliation></author><author><name sortKey="Polychronopoulou, Sophia" sort="Polychronopoulou, Sophia" uniqKey="Polychronopoulou S" first="Sophia" last="Polychronopoulou">Sophia Polychronopoulou</name><affiliation><nlm:aff id="A14">Department of Pediatric Hematology-Oncology, Athens University Medical School, ‘Aghia Sophia’ General Children’s Hospital, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Simpson, Jill" sort="Simpson, Jill" uniqKey="Simpson J" first="Jill" last="Simpson">Jill Simpson</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Rudant, Jeremie" sort="Rudant, Jeremie" uniqKey="Rudant J" first="Jérémie" last="Rudant">Jérémie Rudant</name><affiliation><nlm:aff id="A8">Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Sidi, Vasiliki" sort="Sidi, Vasiliki" uniqKey="Sidi V" first="Vasiliki" last="Sidi">Vasiliki Sidi</name><affiliation><nlm:aff id="A15">Department of Pediatric Hematology-Oncology, Ippokrateion Hospital, Salonica, Greece</nlm:aff></affiliation></author><author><name sortKey="Rondelli, Roberto" sort="Rondelli, Roberto" uniqKey="Rondelli R" first="Roberto" last="Rondelli">Roberto Rondelli</name><affiliation><nlm:aff id="A16">Paediatric Haematology -Oncology, Lalla Seràgnoli, Policlinico Sant’Orsola Malpighi Bologna Italy</nlm:aff></affiliation></author><author><name sortKey="Orsi, Laurent" sort="Orsi, Laurent" uniqKey="Orsi L" first="Laurent" last="Orsi">Laurent Orsi</name><affiliation><nlm:aff id="A8">Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Kang, Alice" sort="Kang, Alice" uniqKey="Kang A" first="Alice" last="Kang">Alice Kang</name><affiliation><nlm:aff id="A11">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff></affiliation></author><author><name sortKey="Petridou, Eleni" sort="Petridou, Eleni" uniqKey="Petridou E" first="Eleni" last="Petridou">Eleni Petridou</name><affiliation><nlm:aff id="A17">Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Medical School, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Schuz, Joachim" sort="Schuz, Joachim" uniqKey="Schuz J" first="Joachim" last="Schüz">Joachim Schüz</name><affiliation><nlm:aff id="A1">International Agency for Research on Cancer (IARC), Section of Environment and Radiation, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France</nlm:aff></affiliation></author></analytic><series><title level="j">International journal of cancer</title><idno type="ISSN">0020-7136</idno><idno type="eISSN">1097-0215</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Maternal occupational pesticide exposure during pregnancy and/or paternal
occupational pesticide exposure around conception have been suggested to increase risk of
leukemia in the offspring. With a view to providing insight in this area we pooled
individual level data from 13 case-control studies participating in the Childhood Leukemia
International Consortium (CLIC). Occupational data were harmonized to a compatible format.
Pooled individual analyses were undertaken using unconditional logistic regression. Using
exposure data from mothers of 8,236 cases, and 14,850 controls, and from fathers of 8,169
cases and 14,201 controls the odds ratio (OR) for maternal exposure during pregnancy and
the risk of acute lymphoblastic leukemia (ALL) was 1.01 (95% confidence interval
(CI) 0.78, 1.30) and for paternal exposure around conception 1.20 (95% 1.06,
1.38). For acute myeloid leukemia (AML), the OR for maternal exposure during pregnancy was
1.94 (CI 1.19, 3.18) and for paternal exposure around conception 0.91 (CI 0.66, 1.24.)
based on data from 1,329 case and 12,141 control mothers, and 1,231 case and 11,383
control fathers. Our finding of a significantly increased risk of AML in the offspring
with maternal exposure to pesticides during pregnancy is consistent with previous reports.
We also found a slight increase in risk of ALL with paternal exposure around conception
which appeared to be more evident in children diagnosed at the age of five years or more
and those with T cell ALL which raises interesting questions on possible mechanisms.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0042124</journal-id><journal-id journal-id-type="pubmed-jr-id">4284</journal-id><journal-id journal-id-type="nlm-ta">Int J Cancer</journal-id><journal-id journal-id-type="iso-abbrev">Int. J. Cancer</journal-id><journal-title-group><journal-title>International journal of cancer</journal-title></journal-title-group><issn pub-type="ppub">0020-7136</issn><issn pub-type="epub">1097-0215</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24700406</article-id><article-id pub-id-type="pmc">4845098</article-id><article-id pub-id-type="doi">10.1002/ijc.28854</article-id><article-id pub-id-type="manuscript">NIHMS577237</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Parental occupational pesticide exposure and the risk of childhood leukemia
in the offspring: Findings from the Childhood Leukemia International
Consortium</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bailey</surname><given-names>Helen D</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Fritschi</surname><given-names>Lin</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Infante-Rivard</surname><given-names>Claire</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Glass</surname><given-names>Deborah C</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Miligi</surname><given-names>Lucia</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Dockerty</surname><given-names>John D</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Lightfoot</surname><given-names>Tracy</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Clavel</surname><given-names>Jacqueline</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Roman</surname><given-names>Eve</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Spector</surname><given-names>Logan G</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Kaatsch</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Metayer</surname><given-names>Catherine</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Magnani</surname><given-names>Corrado</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Milne</surname><given-names>Elizabeth</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Polychronopoulou</surname><given-names>Sophia</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Simpson</surname><given-names>Jill</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Rudant</surname><given-names>Jérémie</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Sidi</surname><given-names>Vasiliki</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Rondelli</surname><given-names>Roberto</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Orsi</surname><given-names>Laurent</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Kang</surname><given-names>Alice</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Petridou</surname><given-names>Eleni</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Schüz</surname><given-names>Joachim</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>International Agency for Research on Cancer (IARC), Section of Environment and Radiation, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France</aff><aff id="A2"><label>2</label>Curtin University, School of Public Health, Perth, Australia</aff><aff id="A3"><label>3</label>Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine, McGill University, Canada</aff><aff id="A4"><label>4</label>Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia</aff><aff id="A5"><label>5</label>ISPO-Cancer Prevention and Research Institute, Occupational and Environmental Epidemiology Unit, Florence, Italy</aff><aff id="A6"><label>6</label>Dean's Department and Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand</aff><aff id="A7"><label>7</label>Department of Health Sciences, University of York, York, United Kingdom</aff><aff id="A8"><label>8</label>Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France</aff><aff id="A9"><label>9</label>Division of Epidemiology Clinical Research, Department of Pediatrics and Masonic Cancer Center, University of Minnesota, Minneapolis, United States</aff><aff id="A10"><label>10</label>German Childhood Cancer Registry (GCCR) at the Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz, Germany</aff><aff id="A11"><label>11</label>University of California, Berkeley, School of Public Health, Berkeley, United States</aff><aff id="A12"><label>12</label>Dipartimento di Medicina Traslazionale – Universita` del Piemonte Orientale, AOU Maggiore della Carita` e CPO – Piemonte, Novara, Italy</aff><aff id="A13"><label>13</label>Telethon Kids Institute, the University of Western Australia, Perth Australia</aff><aff id="A14"><label>14</label>Department of Pediatric Hematology-Oncology, Athens University Medical School, ‘Aghia Sophia’ General Children’s Hospital, Athens, Greece</aff><aff id="A15"><label>15</label>Department of Pediatric Hematology-Oncology, Ippokrateion Hospital, Salonica, Greece</aff><aff id="A16"><label>16</label>Paediatric Haematology -Oncology, Lalla Seràgnoli, Policlinico Sant’Orsola Malpighi Bologna Italy</aff><aff id="A17"><label>17</label>Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Medical School, Athens, Greece</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Helen Bailey, Section of
Environment and Radiation, International Agency for Research on Cancer, 150 cours Albert
Thomas, Lyon 69372 Cedex 08, France. Telephone: [+33] (0)4 72 73 8310. Fax: [+33] (0)4 72
73 8320, <email>baileyh@fellows.iarc.fr</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>1</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>04</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>11</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>26</day><month>4</month><year>2016</year></pub-date><volume>135</volume><issue>9</issue><fpage>2157</fpage><lpage>2172</lpage><pmc-comment>elocation-id from pubmed: 10.1002/ijc.28854</pmc-comment>
<abstract><p id="P1">Maternal occupational pesticide exposure during pregnancy and/or paternal
occupational pesticide exposure around conception have been suggested to increase risk of
leukemia in the offspring. With a view to providing insight in this area we pooled
individual level data from 13 case-control studies participating in the Childhood Leukemia
International Consortium (CLIC). Occupational data were harmonized to a compatible format.
Pooled individual analyses were undertaken using unconditional logistic regression. Using
exposure data from mothers of 8,236 cases, and 14,850 controls, and from fathers of 8,169
cases and 14,201 controls the odds ratio (OR) for maternal exposure during pregnancy and
the risk of acute lymphoblastic leukemia (ALL) was 1.01 (95% confidence interval
(CI) 0.78, 1.30) and for paternal exposure around conception 1.20 (95% 1.06,
1.38). For acute myeloid leukemia (AML), the OR for maternal exposure during pregnancy was
1.94 (CI 1.19, 3.18) and for paternal exposure around conception 0.91 (CI 0.66, 1.24.)
based on data from 1,329 case and 12,141 control mothers, and 1,231 case and 11,383
control fathers. Our finding of a significantly increased risk of AML in the offspring
with maternal exposure to pesticides during pregnancy is consistent with previous reports.
We also found a slight increase in risk of ALL with paternal exposure around conception
which appeared to be more evident in children diagnosed at the age of five years or more
and those with T cell ALL which raises interesting questions on possible mechanisms.</p></abstract><kwd-group><kwd>pesticide</kwd><kwd>occupation</kwd><kwd>leukemia</kwd><kwd>childhood</kwd><kwd>pooled analysis</kwd><kwd>meta-analysis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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