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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Home pesticide exposures and risk of childhood leukemia: Findings from the Childhood Leukemia International Consortium</title><author><name sortKey="Bailey, Helen D" sort="Bailey, Helen D" uniqKey="Bailey H" first="Helen D" last="Bailey">Helen D. Bailey</name><affiliation><nlm:aff id="A1">International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Infante Rivard, Claire" sort="Infante Rivard, Claire" uniqKey="Infante Rivard C" first="Claire" last="Infante-Rivard">Claire Infante-Rivard</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine, McGill University, Canada</nlm:aff></affiliation></author><author><name sortKey="Metayer, Catherine" sort="Metayer, Catherine" uniqKey="Metayer C" first="Catherine" last="Metayer">Catherine Metayer</name><affiliation><nlm:aff id="A3">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff></affiliation></author><author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name><affiliation><nlm:aff id="A4">Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">RNHE - National Registry of Childhood cancers, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Lightfoot, Tracy" sort="Lightfoot, Tracy" uniqKey="Lightfoot T" first="Tracy" last="Lightfoot">Tracy Lightfoot</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Kaatsch, Peter" sort="Kaatsch, Peter" uniqKey="Kaatsch P" first="Peter" last="Kaatsch">Peter Kaatsch</name><affiliation><nlm:aff id="A8">German Childhood Cancer Registry (GCCR) at the Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz, Germany</nlm:aff></affiliation></author><author><name sortKey="Roman, Eve" sort="Roman, Eve" uniqKey="Roman E" first="Eve" last="Roman">Eve Roman</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Magnani, Corrado" sort="Magnani, Corrado" uniqKey="Magnani C" first="Corrado" last="Magnani">Corrado Magnani</name><affiliation><nlm:aff id="A9">Dipartimento di Medicina Traslazionale – Universita` del Piemonte Orientale, AOU Maggiore della Carita` e CPO – Piemonte, Novara, Italy</nlm:aff></affiliation></author><author><name sortKey="Spector, Logan G" sort="Spector, Logan G" uniqKey="Spector L" first="Logan G" last="Spector">Logan G. Spector</name><affiliation><nlm:aff id="A10">Division of Epidemiology Clinical Research, University of Minnesota, Minneapolis, United States</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Department of Pediatrics and Masonic Cancer Center, University of Minnesota, Minneapolis, United States</nlm:aff></affiliation></author><author><name sortKey="Petridou, Eleni" sort="Petridou, Eleni" uniqKey="Petridou E" first="Eleni" last="Petridou">Eleni Petridou</name><affiliation><nlm:aff id="A12">Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Medical School, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Milne, Elizabeth" sort="Milne, Elizabeth" uniqKey="Milne E" first="Elizabeth" last="Milne">Elizabeth Milne</name><affiliation><nlm:aff id="A13">Telethon Kids Institute, University of Western Australia, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="Dockerty, John D" sort="Dockerty, John D" uniqKey="Dockerty J" first="John D" last="Dockerty">John D. Dockerty</name><affiliation><nlm:aff id="A14">Dean's Department and Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand</nlm:aff></affiliation></author><author><name sortKey="Miligi, Lucia" sort="Miligi, Lucia" uniqKey="Miligi L" first="Lucia" last="Miligi">Lucia Miligi</name><affiliation><nlm:aff id="A15">ISPO-Cancer Prevention and Research Institute, Occupational and Environmental Epidemiology Unit, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K" last="Armstrong">Bruce K. Armstrong</name><affiliation><nlm:aff id="A16">Sydney School of Public Health, University of Sydney, New South Wales, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Sax Institute, Ultimo, NSW, Australia.</nlm:aff></affiliation></author><author><name sortKey="Rudant, Jeremie" sort="Rudant, Jeremie" uniqKey="Rudant J" first="Jérémie" last="Rudant">Jérémie Rudant</name><affiliation><nlm:aff id="A4">Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">RNHE - National Registry of Childhood cancers, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Fritschi, Lin" sort="Fritschi, Lin" uniqKey="Fritschi L" first="Lin" last="Fritschi">Lin Fritschi</name><affiliation><nlm:aff id="A18">Curtin University, School of Public Health, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="Simpson, Jill" sort="Simpson, Jill" uniqKey="Simpson J" first="Jill" last="Simpson">Jill Simpson</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Zhang, Luoping" sort="Zhang, Luoping" uniqKey="Zhang L" first="Luoping" last="Zhang">Luoping Zhang</name><affiliation><nlm:aff id="A3">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff></affiliation></author><author><name sortKey="Rondelli, Roberto" sort="Rondelli, Roberto" uniqKey="Rondelli R" first="Roberto" last="Rondelli">Roberto Rondelli</name><affiliation><nlm:aff id="A19">Paediatric Haematology -Oncology, Lalla Seràgnoli, Policlinico Sant’Orsola Malpighi Bologna Italy</nlm:aff></affiliation></author><author><name sortKey="Baka, Margarita" sort="Baka, Margarita" uniqKey="Baka M" first="Margarita" last="Baka">Margarita Baka</name><affiliation><nlm:aff id="A20">Department of Pediatric Hematology-Oncology, ‘‘Pan.&Agl. Kyriakou’’ Children’s Hospital, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Orsi, Laurent" sort="Orsi, Laurent" uniqKey="Orsi L" first="Laurent" last="Orsi">Laurent Orsi</name><affiliation><nlm:aff id="A4">Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris, France</nlm:aff></affiliation></author><author><name sortKey="Moschovi, Maria" sort="Moschovi, Maria" uniqKey="Moschovi M" first="Maria" last="Moschovi">Maria Moschovi</name><affiliation><nlm:aff id="A21">Hematology-Oncology Unit, First Department of Pediatrics, Athens University Medical School, ‘‘Aghia Sophia’’ General Children’s Hospital, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Kang, Alice Y" sort="Kang, Alice Y" uniqKey="Kang A" first="Alice Y" last="Kang">Alice Y. Kang</name><affiliation><nlm:aff id="A3">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff></affiliation></author><author><name sortKey="Schuz, Joachim" sort="Schuz, Joachim" uniqKey="Schuz J" first="Joachim" last="Schüz">Joachim Schüz</name><affiliation><nlm:aff id="A1">International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26061779</idno><idno type="pmc">4572913</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572913</idno><idno type="RBID">PMC:4572913</idno><idno type="doi">10.1002/ijc.29631</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001C56</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C56</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Home pesticide exposures and risk of childhood leukemia: Findings from the Childhood Leukemia International Consortium</title><author><name sortKey="Bailey, Helen D" sort="Bailey, Helen D" uniqKey="Bailey H" first="Helen D" last="Bailey">Helen D. Bailey</name><affiliation><nlm:aff id="A1">International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Infante Rivard, Claire" sort="Infante Rivard, Claire" uniqKey="Infante Rivard C" first="Claire" last="Infante-Rivard">Claire Infante-Rivard</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine, McGill University, Canada</nlm:aff></affiliation></author><author><name sortKey="Metayer, Catherine" sort="Metayer, Catherine" uniqKey="Metayer C" first="Catherine" last="Metayer">Catherine Metayer</name><affiliation><nlm:aff id="A3">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff></affiliation></author><author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name><affiliation><nlm:aff id="A4">Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">RNHE - National Registry of Childhood cancers, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Lightfoot, Tracy" sort="Lightfoot, Tracy" uniqKey="Lightfoot T" first="Tracy" last="Lightfoot">Tracy Lightfoot</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Kaatsch, Peter" sort="Kaatsch, Peter" uniqKey="Kaatsch P" first="Peter" last="Kaatsch">Peter Kaatsch</name><affiliation><nlm:aff id="A8">German Childhood Cancer Registry (GCCR) at the Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz, Germany</nlm:aff></affiliation></author><author><name sortKey="Roman, Eve" sort="Roman, Eve" uniqKey="Roman E" first="Eve" last="Roman">Eve Roman</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Magnani, Corrado" sort="Magnani, Corrado" uniqKey="Magnani C" first="Corrado" last="Magnani">Corrado Magnani</name><affiliation><nlm:aff id="A9">Dipartimento di Medicina Traslazionale – Universita` del Piemonte Orientale, AOU Maggiore della Carita` e CPO – Piemonte, Novara, Italy</nlm:aff></affiliation></author><author><name sortKey="Spector, Logan G" sort="Spector, Logan G" uniqKey="Spector L" first="Logan G" last="Spector">Logan G. Spector</name><affiliation><nlm:aff id="A10">Division of Epidemiology Clinical Research, University of Minnesota, Minneapolis, United States</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Department of Pediatrics and Masonic Cancer Center, University of Minnesota, Minneapolis, United States</nlm:aff></affiliation></author><author><name sortKey="Petridou, Eleni" sort="Petridou, Eleni" uniqKey="Petridou E" first="Eleni" last="Petridou">Eleni Petridou</name><affiliation><nlm:aff id="A12">Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Medical School, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Milne, Elizabeth" sort="Milne, Elizabeth" uniqKey="Milne E" first="Elizabeth" last="Milne">Elizabeth Milne</name><affiliation><nlm:aff id="A13">Telethon Kids Institute, University of Western Australia, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="Dockerty, John D" sort="Dockerty, John D" uniqKey="Dockerty J" first="John D" last="Dockerty">John D. Dockerty</name><affiliation><nlm:aff id="A14">Dean's Department and Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand</nlm:aff></affiliation></author><author><name sortKey="Miligi, Lucia" sort="Miligi, Lucia" uniqKey="Miligi L" first="Lucia" last="Miligi">Lucia Miligi</name><affiliation><nlm:aff id="A15">ISPO-Cancer Prevention and Research Institute, Occupational and Environmental Epidemiology Unit, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K" last="Armstrong">Bruce K. Armstrong</name><affiliation><nlm:aff id="A16">Sydney School of Public Health, University of Sydney, New South Wales, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Sax Institute, Ultimo, NSW, Australia.</nlm:aff></affiliation></author><author><name sortKey="Rudant, Jeremie" sort="Rudant, Jeremie" uniqKey="Rudant J" first="Jérémie" last="Rudant">Jérémie Rudant</name><affiliation><nlm:aff id="A4">Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">RNHE - National Registry of Childhood cancers, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Fritschi, Lin" sort="Fritschi, Lin" uniqKey="Fritschi L" first="Lin" last="Fritschi">Lin Fritschi</name><affiliation><nlm:aff id="A18">Curtin University, School of Public Health, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="Simpson, Jill" sort="Simpson, Jill" uniqKey="Simpson J" first="Jill" last="Simpson">Jill Simpson</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Zhang, Luoping" sort="Zhang, Luoping" uniqKey="Zhang L" first="Luoping" last="Zhang">Luoping Zhang</name><affiliation><nlm:aff id="A3">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff></affiliation></author><author><name sortKey="Rondelli, Roberto" sort="Rondelli, Roberto" uniqKey="Rondelli R" first="Roberto" last="Rondelli">Roberto Rondelli</name><affiliation><nlm:aff id="A19">Paediatric Haematology -Oncology, Lalla Seràgnoli, Policlinico Sant’Orsola Malpighi Bologna Italy</nlm:aff></affiliation></author><author><name sortKey="Baka, Margarita" sort="Baka, Margarita" uniqKey="Baka M" first="Margarita" last="Baka">Margarita Baka</name><affiliation><nlm:aff id="A20">Department of Pediatric Hematology-Oncology, ‘‘Pan.&Agl. Kyriakou’’ Children’s Hospital, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Orsi, Laurent" sort="Orsi, Laurent" uniqKey="Orsi L" first="Laurent" last="Orsi">Laurent Orsi</name><affiliation><nlm:aff id="A4">Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris, France</nlm:aff></affiliation></author><author><name sortKey="Moschovi, Maria" sort="Moschovi, Maria" uniqKey="Moschovi M" first="Maria" last="Moschovi">Maria Moschovi</name><affiliation><nlm:aff id="A21">Hematology-Oncology Unit, First Department of Pediatrics, Athens University Medical School, ‘‘Aghia Sophia’’ General Children’s Hospital, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Kang, Alice Y" sort="Kang, Alice Y" uniqKey="Kang A" first="Alice Y" last="Kang">Alice Y. Kang</name><affiliation><nlm:aff id="A3">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff></affiliation></author><author><name sortKey="Schuz, Joachim" sort="Schuz, Joachim" uniqKey="Schuz J" first="Joachim" last="Schüz">Joachim Schüz</name><affiliation><nlm:aff id="A1">International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France</nlm:aff></affiliation></author></analytic><series><title level="j">International journal of cancer. Journal international du cancer</title><idno type="ISSN">0020-7136</idno><idno type="eISSN">1097-0215</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Some previous studies have suggested that home pesticide exposure before birth and during a child's early years may increase the risk of childhood leukemia. To further investigate this, we pooled individual level data from 12 case-control studies in the Childhood Leukemia International Consortium (CLIC). Exposure data were harmonized into compatible formats. Pooled analyses were undertaken using multivariable unconditional logistic regression. The odds ratio (ORs) for acute lymphoblastic leukaemia (ALL) associated with any pesticide exposure shortly before conception, during pregnancy and after birth were 1.39 (95% confidence interval (CI) 1.25, 1.55) (using (2,785 cases, 3635 controls), 1.43 (95% CI 1.32, 1.54) (5,055 cases, 7,370 controls) and 1.36 (95% CI 1.23, 1.51) (4,162 cases 5,179 controls), respectively. Corresponding ORs for risk of acute myeloid leukaemia (AML) were 1.49 (95% CI 1.02, 2.16) (173 cases, 1,789 controls), 1.55 (95% CI 1.21, 1.99) (344 cases, 4,666 controls) and 1.08 (95% CI 0.76, 1.53) (198 cases, 2,655 controls) respectively. There was little difference by type of pesticide used. The relative similarity in ORs between leukaemia types, time periods and pesticide types may be explained by similar exposure patterns and effects across the time periods in ALL and AML, participants’ exposure to multiple pesticides, or recall bias. Although some recall bias is likely, until a better study design can be found to investigate associations between home pesticide use and childhood leukaemia in an equally large sample, it would appear prudent to limit the use of home pesticides before and during pregnancy, and during childhood.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0042124</journal-id><journal-id journal-id-type="pubmed-jr-id">4284</journal-id><journal-id journal-id-type="nlm-ta">Int J Cancer</journal-id><journal-id journal-id-type="iso-abbrev">Int. J. Cancer</journal-id><journal-title-group><journal-title>International journal of cancer. Journal international du cancer</journal-title></journal-title-group><issn pub-type="ppub">0020-7136</issn><issn pub-type="epub">1097-0215</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26061779</article-id><article-id pub-id-type="pmc">4572913</article-id><article-id pub-id-type="doi">10.1002/ijc.29631</article-id><article-id pub-id-type="manuscript">NIHMS699178</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Home pesticide exposures and risk of childhood leukemia: Findings from the Childhood Leukemia International Consortium</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bailey</surname><given-names>Helen D</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Infante-Rivard</surname><given-names>Claire</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Metayer</surname><given-names>Catherine</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Clavel</surname><given-names>Jacqueline</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Lightfoot</surname><given-names>Tracy</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Kaatsch</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Roman</surname><given-names>Eve</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Magnani</surname><given-names>Corrado</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Spector</surname><given-names>Logan G</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Petridou</surname><given-names>Eleni</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Milne</surname><given-names>Elizabeth</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Dockerty</surname><given-names>John D</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Miligi</surname><given-names>Lucia</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Armstrong</surname><given-names>Bruce K</given-names></name><xref ref-type="aff" rid="A16">16</xref><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Rudant</surname><given-names>Jérémie</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Fritschi</surname><given-names>Lin</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Simpson</surname><given-names>Jill</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Luoping</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Rondelli</surname><given-names>Roberto</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Baka</surname><given-names>Margarita</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Orsi</surname><given-names>Laurent</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Moschovi</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Kang</surname><given-names>Alice Y</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Schüz</surname><given-names>Joachim</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France</aff><aff id="A2"><label>2</label>Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine, McGill University, Canada</aff><aff id="A3"><label>3</label>University of California, Berkeley, School of Public Health, Berkeley, United States</aff><aff id="A4"><label>4</label>Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif, France</aff><aff id="A5"><label>5</label>Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris, France</aff><aff id="A6"><label>6</label>RNHE - National Registry of Childhood cancers, Villejuif, France</aff><aff id="A7"><label>7</label>Department of Health Sciences, University of York, York, United Kingdom</aff><aff id="A8"><label>8</label>German Childhood Cancer Registry (GCCR) at the Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz, Germany</aff><aff id="A9"><label>9</label>Dipartimento di Medicina Traslazionale – Universita` del Piemonte Orientale, AOU Maggiore della Carita` e CPO – Piemonte, Novara, Italy</aff><aff id="A10"><label>10</label>Division of Epidemiology Clinical Research, University of Minnesota, Minneapolis, United States</aff><aff id="A11"><label>11</label>Department of Pediatrics and Masonic Cancer Center, University of Minnesota, Minneapolis, United States</aff><aff id="A12"><label>12</label>Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Medical School, Athens, Greece</aff><aff id="A13"><label>13</label>Telethon Kids Institute, University of Western Australia, Perth, Australia</aff><aff id="A14"><label>14</label>Dean's Department and Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand</aff><aff id="A15"><label>15</label>ISPO-Cancer Prevention and Research Institute, Occupational and Environmental Epidemiology Unit, Florence, Italy</aff><aff id="A16"><label>16</label>Sydney School of Public Health, University of Sydney, New South Wales, Australia</aff><aff id="A17"><label>17</label>Sax Institute, Ultimo, NSW, Australia.</aff><aff id="A18"><label>18</label>Curtin University, School of Public Health, Perth, Australia</aff><aff id="A19"><label>19</label>Paediatric Haematology -Oncology, Lalla Seràgnoli, Policlinico Sant’Orsola Malpighi Bologna Italy</aff><aff id="A20"><label>20</label>Department of Pediatric Hematology-Oncology, ‘‘Pan.&Agl. Kyriakou’’ Children’s Hospital, Athens, Greece</aff><aff id="A21"><label>21</label>Hematology-Oncology Unit, First Department of Pediatrics, Athens University Medical School, ‘‘Aghia Sophia’’ General Children’s Hospital, Athens, Greece</aff><author-notes><corresp id="CR1"><bold>Address for correspondence:</bold> Joachim Schüz, Section of Environment and Radiation, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon 69372 Cedex 08, France. Telephone: [+33] (0)4 72 73 8441. Fax: [+33] (0)4 72 73 8320 <email>SchuzJ@iarc.fr</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>20</day><month>7</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>26</day><month>6</month><year>2015</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>12</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>12</month><year>2016</year></pub-date><volume>137</volume><issue>11</issue><fpage>2644</fpage><lpage>2663</lpage><pmc-comment>elocation-id from pubmed: 10.1002/ijc.29631</pmc-comment>
<abstract><p id="P1">Some previous studies have suggested that home pesticide exposure before birth and during a child's early years may increase the risk of childhood leukemia. To further investigate this, we pooled individual level data from 12 case-control studies in the Childhood Leukemia International Consortium (CLIC). Exposure data were harmonized into compatible formats. Pooled analyses were undertaken using multivariable unconditional logistic regression. The odds ratio (ORs) for acute lymphoblastic leukaemia (ALL) associated with any pesticide exposure shortly before conception, during pregnancy and after birth were 1.39 (95% confidence interval (CI) 1.25, 1.55) (using (2,785 cases, 3635 controls), 1.43 (95% CI 1.32, 1.54) (5,055 cases, 7,370 controls) and 1.36 (95% CI 1.23, 1.51) (4,162 cases 5,179 controls), respectively. Corresponding ORs for risk of acute myeloid leukaemia (AML) were 1.49 (95% CI 1.02, 2.16) (173 cases, 1,789 controls), 1.55 (95% CI 1.21, 1.99) (344 cases, 4,666 controls) and 1.08 (95% CI 0.76, 1.53) (198 cases, 2,655 controls) respectively. There was little difference by type of pesticide used. The relative similarity in ORs between leukaemia types, time periods and pesticide types may be explained by similar exposure patterns and effects across the time periods in ALL and AML, participants’ exposure to multiple pesticides, or recall bias. Although some recall bias is likely, until a better study design can be found to investigate associations between home pesticide use and childhood leukaemia in an equally large sample, it would appear prudent to limit the use of home pesticides before and during pregnancy, and during childhood.</p></abstract><kwd-group><kwd>pesticide</kwd><kwd>acute lymphoblastic leukemia acute myeloid leukemia</kwd><kwd>childhood</kwd><kwd>pooled analysis</kwd><kwd>case-control study</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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