Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells</title><author><name sortKey="Ferrand, Audrey" sort="Ferrand, Audrey" uniqKey="Ferrand A" first="Audrey" last="Ferrand">Audrey Ferrand</name></author><author><name sortKey="Kowalski Chauvel, Aline" sort="Kowalski Chauvel, Aline" uniqKey="Kowalski Chauvel A" first="Aline" last="Kowalski-Chauvel">Aline Kowalski-Chauvel</name></author><author><name sortKey="Pannequin, Julie" sort="Pannequin, Julie" uniqKey="Pannequin J" first="Julie" last="Pannequin">Julie Pannequin</name></author><author><name sortKey="Bertrand, Claudine" sort="Bertrand, Claudine" uniqKey="Bertrand C" first="Claudine" last="Bertrand">Claudine Bertrand</name></author><author><name sortKey="Fourmy, Daniel" sort="Fourmy, Daniel" uniqKey="Fourmy D" first="Daniel" last="Fourmy">Daniel Fourmy</name></author><author><name sortKey="Dufresne, Marlene" sort="Dufresne, Marlene" uniqKey="Dufresne M" first="Marlene" last="Dufresne">Marlene Dufresne</name></author><author><name sortKey="Seva, Catherine" sort="Seva, Catherine" uniqKey="Seva C" first="Catherine" last="Seva">Catherine Seva</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16609991</idno><idno type="pmc">4087510</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087510</idno><idno type="RBID">PMC:4087510</idno><idno type="doi">10.3748/wjg.v12.i12.1859</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">001C36</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C36</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells</title><author><name sortKey="Ferrand, Audrey" sort="Ferrand, Audrey" uniqKey="Ferrand A" first="Audrey" last="Ferrand">Audrey Ferrand</name></author><author><name sortKey="Kowalski Chauvel, Aline" sort="Kowalski Chauvel, Aline" uniqKey="Kowalski Chauvel A" first="Aline" last="Kowalski-Chauvel">Aline Kowalski-Chauvel</name></author><author><name sortKey="Pannequin, Julie" sort="Pannequin, Julie" uniqKey="Pannequin J" first="Julie" last="Pannequin">Julie Pannequin</name></author><author><name sortKey="Bertrand, Claudine" sort="Bertrand, Claudine" uniqKey="Bertrand C" first="Claudine" last="Bertrand">Claudine Bertrand</name></author><author><name sortKey="Fourmy, Daniel" sort="Fourmy, Daniel" uniqKey="Fourmy D" first="Daniel" last="Fourmy">Daniel Fourmy</name></author><author><name sortKey="Dufresne, Marlene" sort="Dufresne, Marlene" uniqKey="Dufresne M" first="Marlene" last="Dufresne">Marlene Dufresne</name></author><author><name sortKey="Seva, Catherine" sort="Seva, Catherine" uniqKey="Seva C" first="Catherine" last="Seva">Catherine Seva</name></author></analytic><series><title level="j">World Journal of Gastroenterology : WJG</title><idno type="ISSN">1007-9327</idno><idno type="eISSN">2219-2840</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>AIM: To investigate whether Src, JAK2 and phosphatidylinositol 3-kinase (PI3K) pathways are involved in the proliferation of human colonic tumour cells induced by glycine-extended gastrin (G-gly), the precursor of the mature amidated gastrin and to elucidate the molecular interaction between these three kinases in response to this peptide.</p><p>METHODS: Using the human colonic tumour cell line HCT116 as a model, we first measured the activation of PI3K, p60-Src and JAK2 in response to G-gly by in vitro kinase assays. Then we investigated the involvement of these kinases in G-gly-induced cell proliferation by MTT test.</p><p>RESULTS: G-gly stimulation induced p60-Src, JAK2 and PI3K activation in HCT116. The different pathways were involved in proliferation of human colon cancer cells induced by G-gly. Furthermore, we found that both Src and JAK2 were necessary to PI3K regulation by this peptide. However, we did not find any cross-talk between the two tyrosine kinases.</p><p>CONCLUSION: Our results suggest that the p60-Src/PI3K and JAK2/PI3K pathways act independently to mediate G-gly proliferative effect on human colonic tumour cells.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">World J Gastroenterol</journal-id><journal-id journal-id-type="iso-abbrev">World J. Gastroenterol</journal-id><journal-id journal-id-type="publisher-id">WJG</journal-id><journal-title-group><journal-title>World Journal of Gastroenterology : WJG</journal-title></journal-title-group><issn pub-type="ppub">1007-9327</issn><issn pub-type="epub">2219-2840</issn><publisher><publisher-name>Baishideng Publishing Group Co., Limited</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16609991</article-id><article-id pub-id-type="pmc">4087510</article-id><article-id pub-id-type="other">jWJG.v12.i12.pg1859</article-id><article-id pub-id-type="doi">10.3748/wjg.v12.i12.1859</article-id><article-categories><subj-group subj-group-type="heading"><subject>Colorectal Cancer</subject></subj-group></article-categories><title-group><article-title>Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ferrand</surname><given-names>Audrey</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kowalski-Chauvel</surname><given-names>Aline</given-names></name></contrib><contrib contrib-type="author"><name><surname>Pannequin</surname><given-names>Julie</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bertrand</surname><given-names>Claudine</given-names></name></contrib><contrib contrib-type="author"><name><surname>Fourmy</surname><given-names>Daniel</given-names></name></contrib><contrib contrib-type="author"><name><surname>Dufresne</surname><given-names>Marlene</given-names></name></contrib><contrib contrib-type="author"><name><surname>Seva</surname><given-names>Catherine</given-names></name></contrib><aff>Audrey Ferrand, Aline Kowalski-Chauvel, Claudine Bertrand, Daniel Fourmy, Marlene Dufresne, Catherine Seva, INSERM U.531, Groupe de Recherche de Biologie et Pathologie Digestives, IFR31, Institut Louis Bugnard, BP 84225, 31432 toulouse Cedex 4, France</aff><aff>Julie Pannequin, University of Melbourne Department of Surgery, Austin Campus, ARMC, Heidelberg, Victoria 3084, Australia</aff></contrib-group><author-notes><fn><p>Correspondence to: Catherine Seva, IFR31, Institut Louis Bugnard, BP 84225, Unité INSERM 531, Biologie et Pathologie Digestives, 31432 toulouse Cedex 4, France. <email>sevac@toulouse.inserm.fr</email></p><p>Telephone: +33-5-61322408 Fax: +33-5-61322403</p></fn></author-notes><pub-date pub-type="ppub"><day>28</day><month>3</month><year>2006</year></pub-date><pub-date pub-type="epub"><day>28</day><month>3</month><year>2006</year></pub-date><volume>12</volume><issue>12</issue><fpage>1859</fpage><lpage>1864</lpage><history><date date-type="received"><day>13</day><month>9</month><year>2005</year></date><date date-type="rev-recd"><day>2</day><month>10</month><year>2005</year></date><date date-type="accepted"><day>26</day><month>10</month><year>2005</year></date></history><permissions><copyright-statement>©2006 Baishideng Publishing Group Co., Limited. All rights reserved.</copyright-statement><copyright-year>2006</copyright-year></permissions><abstract><p>AIM: To investigate whether Src, JAK2 and phosphatidylinositol 3-kinase (PI3K) pathways are involved in the proliferation of human colonic tumour cells induced by glycine-extended gastrin (G-gly), the precursor of the mature amidated gastrin and to elucidate the molecular interaction between these three kinases in response to this peptide.</p><p>METHODS: Using the human colonic tumour cell line HCT116 as a model, we first measured the activation of PI3K, p60-Src and JAK2 in response to G-gly by in vitro kinase assays. Then we investigated the involvement of these kinases in G-gly-induced cell proliferation by MTT test.</p><p>RESULTS: G-gly stimulation induced p60-Src, JAK2 and PI3K activation in HCT116. The different pathways were involved in proliferation of human colon cancer cells induced by G-gly. Furthermore, we found that both Src and JAK2 were necessary to PI3K regulation by this peptide. However, we did not find any cross-talk between the two tyrosine kinases.</p><p>CONCLUSION: Our results suggest that the p60-Src/PI3K and JAK2/PI3K pathways act independently to mediate G-gly proliferative effect on human colonic tumour cells.</p></abstract><kwd-group><kwd>Colon cancer</kwd><kwd>Src</kwd><kwd>JAK2</kwd><kwd>Phosphatidylinositol 3-kinase</kwd><kwd>Glycine-extended gastrin</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C36 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001C36 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |