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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>KLB</italic> is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference</title><author><name sortKey="Schumann, Gunter" sort="Schumann, Gunter" uniqKey="Schumann G" first="Gunter" last="Schumann">Gunter Schumann</name><affiliation><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Liu, Chunyu" sort="Liu, Chunyu" uniqKey="Liu C" first="Chunyu" last="Liu">Chunyu Liu</name><affiliation><nlm:aff id="aff2"><institution>The Framingham Heart Study</institution>, Framingham,<addr-line>MA</addr-line> 01702;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">The Population Sciences Branch, Division of Intramural Research,<institution>National Heart, Lung, and Blood Institute</institution>, Bethesda,<addr-line>MD</addr-line> 20824;</nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>Department of Biostatistics, Boston University School of Public Health</institution>, Boston,<addr-line>MA</addr-line> 02118;</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Paul" sort="O Eilly, Paul" uniqKey="O Eilly P" first="Paul" last="O Eilly">Paul O Eilly</name><affiliation><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Gao, He" sort="Gao, He" uniqKey="Gao H" first="He" last="Gao">He Gao</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff6">Medical Research Council-Public Health England Centre for Environment and Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Song, Parkyong" sort="Song, Parkyong" uniqKey="Song P" first="Parkyong" last="Song">Parkyong Song</name><affiliation><nlm:aff id="aff7">Department of Pharmacology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation><affiliation><nlm:aff id="aff8"><institution>Howard Hughes Medical Institute</institution>,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation></author><author><name sortKey="Xu, Bing" sort="Xu, Bing" uniqKey="Xu B" first="Bing" last="Xu">Bing Xu</name><affiliation><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Ruggeri, Barbara" sort="Ruggeri, Barbara" uniqKey="Ruggeri B" first="Barbara" last="Ruggeri">Barbara Ruggeri</name><affiliation><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:aff id="aff9">Genetic Epidemiology Unit, Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Jia, Tianye" sort="Jia, Tianye" uniqKey="Jia T" first="Tianye" last="Jia">Tianye Jia</name><affiliation><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Preis, Sarah" sort="Preis, Sarah" uniqKey="Preis S" first="Sarah" last="Preis">Sarah Preis</name><affiliation><nlm:aff id="aff4"><institution>Department of Biostatistics, Boston University School of Public Health</institution>, Boston,<addr-line>MA</addr-line> 02118;</nlm:aff></affiliation></author><author><name sortKey="Segura Lepe, Marcelo" sort="Segura Lepe, Marcelo" uniqKey="Segura Lepe M" first="Marcelo" last="Segura Lepe">Marcelo Segura Lepe</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff10"><institution>Section of Bioinformatics, Bayer Pharma AG</institution>, 13342 Berlin,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Akira, Shizuo" sort="Akira, Shizuo" uniqKey="Akira S" first="Shizuo" last="Akira">Shizuo Akira</name><affiliation><nlm:aff id="aff11">Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases,<institution>Osaka University</institution>, Osaka 565-0871,<country>Japan</country>;</nlm:aff></affiliation></author><author><name sortKey="Barbieri, Caterina" sort="Barbieri, Caterina" uniqKey="Barbieri C" first="Caterina" last="Barbieri">Caterina Barbieri</name><affiliation><nlm:aff id="aff12">Division of Genetics and Cell Biology,<institution>San Raffaele Research Institute</institution>, 20132 Milan,<country>Italy</country>;</nlm:aff></affiliation></author><author><name sortKey="Baumeister, Sebastian" sort="Baumeister, Sebastian" uniqKey="Baumeister S" first="Sebastian" last="Baumeister">Sebastian Baumeister</name><affiliation><nlm:aff id="aff13">Institute for Community Medicine,<institution>University Medicine Greifswald</institution>, Greifswald 17475,<country>Germany</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">Department of Epidemiology and Preventive Medicine,<institution>University of Regensburg</institution>, 93053 Regensburg,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Cauchi, Stephane" sort="Cauchi, Stephane" uniqKey="Cauchi S" first="Stephane" last="Cauchi">Stephane Cauchi</name><affiliation><nlm:aff id="aff15">CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes,<institution>Lille 2 University</institution>, 59000 Lille,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Clarke, Toni Kim" sort="Clarke, Toni Kim" uniqKey="Clarke T" first="Toni-Kim" last="Clarke">Toni-Kim Clarke</name><affiliation><nlm:aff id="aff16">Divison of Psychiatry,<institution>University of Edinburgh</institution>, Edinburgh EH10 5HF,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Enroth, Stefan" sort="Enroth, Stefan" uniqKey="Enroth S" first="Stefan" last="Enroth">Stefan Enroth</name><affiliation><nlm:aff id="aff17">Science for Life Laboratory, Department of Immunology, Genetics and Pathology,<institution>Uppsala University</institution>, 75108 Uppsala,<country>Sweden</country>;</nlm:aff></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation><nlm:aff id="aff18">Estonian Genome Center,<institution>University of Tartu</institution>, 51010 Tartu,<country>Estonia</country>;</nlm:aff></affiliation></author><author><name sortKey="H Llfors, Jenni" sort="H Llfors, Jenni" uniqKey="H Llfors J" first="Jenni" last="H Llfors">Jenni H Llfors</name><affiliation><nlm:aff id="aff19">Institute for Molecular Medicine,<institution>University of Helsinki</institution>, 00290 Helsinki,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Harris, Sarah E" sort="Harris, Sarah E" uniqKey="Harris S" first="Sarah E." last="Harris">Sarah E. Harris</name><affiliation><nlm:aff id="aff20">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff21">Centre for Genomic and Experimental Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Hieber, Saskia" sort="Hieber, Saskia" uniqKey="Hieber S" first="Saskia" last="Hieber">Saskia Hieber</name><affiliation><nlm:aff id="aff22">Department of Psychiatry and Psychotherapy,<institution>Friedrich Alexander University Erlangen-Nuremberg</institution>, 91054 Erlangen,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Hofer, Edith" sort="Hofer, Edith" uniqKey="Hofer E" first="Edith" last="Hofer">Edith Hofer</name><affiliation><nlm:aff id="aff23">Clinical Division of Neurogeriatrics, Department of Neurology,<institution>Medical University Graz</institution>, 8036 Graz,<country>Austria</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff24">Institute of Medical Informatics, Statistics and Documentation,<institution>Medical University Graz</institution>, 8036 Graz,<country>Austria</country>;</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="aff25">Department of Biological Psychology,<institution>Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research</institution>, 1081 BT Amsterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="aff17">Science for Life Laboratory, Department of Immunology, Genetics and Pathology,<institution>Uppsala University</institution>, 75108 Uppsala,<country>Sweden</country>;</nlm:aff></affiliation></author><author><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K." last="Joshi">Peter K. Joshi</name><affiliation><nlm:aff id="aff26">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH8 9AG,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Kaartinen, Niina" sort="Kaartinen, Niina" uniqKey="Kaartinen N" first="Niina" last="Kaartinen">Niina Kaartinen</name><affiliation><nlm:aff id="aff27"><institution>National Institute for Health and Welfare</institution>, 00271 Helsinki,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><affiliation><nlm:aff id="aff28"><institution>Quantified Employee-Unit, Finnish Institute of Occupational Health</institution>, 00250 Helsinki,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Lemaitre, Rozenn" sort="Lemaitre, Rozenn" uniqKey="Lemaitre R" first="Rozenn" last="Lemaitre">Rozenn Lemaitre</name><affiliation><nlm:aff id="aff29">Cardiovascular Health Research Unit, Department of Medicine,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98101;</nlm:aff></affiliation></author><author><name sortKey="Loukola, Anu" sort="Loukola, Anu" uniqKey="Loukola A" first="Anu" last="Loukola">Anu Loukola</name><affiliation><nlm:aff id="aff19">Institute for Molecular Medicine,<institution>University of Helsinki</institution>, 00290 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff30">Department of Public Health,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation><nlm:aff id="aff31">Medical Research Council Epidemiology Unit, Institute of Metabolic Science,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation><nlm:aff id="aff32">Department of Clinical Chemistry,<institution>Fimlab Laboratories and University of Tampere School of Medicine</institution>, Tampere 33520,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="aff33">Department of Twin Research and Genetic Epidemiology,<institution>King’s College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff34"><institution>National Institute for Health Research Biomedical Research Centre at Guy’s and St. Thomas’ Foundation Trust</institution>, London SE1 9RT, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Manichaikul, Ani" sort="Manichaikul, Ani" uniqKey="Manichaikul A" first="Ani" last="Manichaikul">Ani Manichaikul</name><affiliation><nlm:aff id="aff35">Center for Public Health Genomics, Department of Public Health Sciences,<institution>University of Virginia</institution>, Charlottesville,<addr-line>VA</addr-line> 22903;</nlm:aff></affiliation><affiliation><nlm:aff id="aff36">Biostatistics Section, Department of Public Health Sciences,<institution>University of Virginia</institution>, Charlottesville,<addr-line>VA</addr-line> 22903;</nlm:aff></affiliation></author><author><name sortKey="Mbarek, Hamdi" sort="Mbarek, Hamdi" uniqKey="Mbarek H" first="Hamdi" last="Mbarek">Hamdi Mbarek</name><affiliation><nlm:aff id="aff25">Department of Biological Psychology,<institution>Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research</institution>, 1081 BT Amsterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Milaneschi, Yuri" sort="Milaneschi, Yuri" uniqKey="Milaneschi Y" first="Yuri" last="Milaneschi">Yuri Milaneschi</name><affiliation><nlm:aff id="aff37">Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam,<institution>Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest</institution>, 1081 HL Amsterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Moayyeri, Alireza" sort="Moayyeri, Alireza" uniqKey="Moayyeri A" first="Alireza" last="Moayyeri">Alireza Moayyeri</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff38">Institute of Health Informatics,<institution>University College London</institution>, London NW1 2DA,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff39"><institution>Farr Institute of Health Informatics Research</institution>, University College London Institute of Health Informatics, London NW1 2DA,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Mukamal, Kenneth" sort="Mukamal, Kenneth" uniqKey="Mukamal K" first="Kenneth" last="Mukamal">Kenneth Mukamal</name><affiliation><nlm:aff id="aff40">Department of Medicine,<institution>Beth Israel Deaconess Medical Center and Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02215;</nlm:aff></affiliation></author><author><name sortKey="Nelson, Christopher" sort="Nelson, Christopher" uniqKey="Nelson C" first="Christopher" last="Nelson">Christopher Nelson</name><affiliation><nlm:aff id="aff41">Department of Cardiovascular Sciences, University of Leicester,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff42">National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Nettleton, Jennifer" sort="Nettleton, Jennifer" uniqKey="Nettleton J" first="Jennifer" last="Nettleton">Jennifer Nettleton</name><affiliation><nlm:aff id="aff43">Division of Epidemiology, Human Genetics, and Environmental Sciences,<institution>University of Texas Health Sciences Center</institution>, Houston,<addr-line>TX</addr-line> 77225;</nlm:aff></affiliation></author><author><name sortKey="Partinen, Eemil" sort="Partinen, Eemil" uniqKey="Partinen E" first="Eemil" last="Partinen">Eemil Partinen</name><affiliation><nlm:aff id="aff44">Faculty of Medicine,<institution>University of Tartu</institution>, 50411 Tartu,<country>Estonia</country>;</nlm:aff></affiliation></author><author><name sortKey="Rawal, Rajesh" sort="Rawal, Rajesh" uniqKey="Rawal R" first="Rajesh" last="Rawal">Rajesh Rawal</name><affiliation><nlm:aff id="aff45">Department of Molecular Epidemiology, Institute of Epidemiology II,<institution>Helmholtz Zentrum München</institution>, 85764 Neuherberg,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><affiliation><nlm:aff id="aff46"><institution>Institute for Maternal and Child Health—Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo</institution>, 34137 Trieste,<country>Italy</country>;</nlm:aff></affiliation></author><author><name sortKey="Rose, Lynda" sort="Rose, Lynda" uniqKey="Rose L" first="Lynda" last="Rose">Lynda Rose</name><affiliation><nlm:aff id="aff47">Division of Preventive Medicine,<institution>Brigham and Women’s Hospital</institution>, Boston,<addr-line>MA</addr-line> 02215;</nlm:aff></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation><nlm:aff id="aff12">Division of Genetics and Cell Biology,<institution>San Raffaele Research Institute</institution>, 20132 Milan,<country>Italy</country>;</nlm:aff></affiliation></author><author><name sortKey="Satoh, Takashi" sort="Satoh, Takashi" uniqKey="Satoh T" first="Takashi" last="Satoh">Takashi Satoh</name><affiliation><nlm:aff id="aff11">Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases,<institution>Osaka University</institution>, Osaka 565-0871,<country>Japan</country>;</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation><nlm:aff id="aff23">Clinical Division of Neurogeriatrics, Department of Neurology,<institution>Medical University Graz</institution>, 8036 Graz,<country>Austria</country>;</nlm:aff></affiliation></author><author><name sortKey="Schraut, Katharina" sort="Schraut, Katharina" uniqKey="Schraut K" first="Katharina" last="Schraut">Katharina Schraut</name><affiliation><nlm:aff id="aff26">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH8 9AG,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Scott, Robert" sort="Scott, Robert" uniqKey="Scott R" first="Robert" last="Scott">Robert Scott</name><affiliation><nlm:aff id="aff48">Medical Research Council Epidemiology Unit,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation><nlm:aff id="aff49"><institution>Research Institute, Icelandic Heart Association</institution>, 201 Kopavogur,<country>Iceland</country>;</nlm:aff></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation><nlm:aff id="aff20">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff50">Alzheimer Scotland Research Centre,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="aff13">Institute for Community Medicine,<institution>University Medicine Greifswald</institution>, Greifswald 17475,<country>Germany</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff51">Interfaculty Institute for Genetics and Functional Genomics,<institution>University Medicine Greifswald</institution>, 17475 Greifswald,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation><nlm:aff id="aff52">Department of Cardiology,<institution>Leiden University Medical Center</institution>, 2300 RC Leiden,<country>The Netherlands</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff53">Department of Gerontology and Geriatrics,<institution>Leiden University Medical Center</institution>, 2300 RC Leiden,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation><nlm:aff id="aff54">Department of internal Medicine,<institution>Erasmus Medical Center</institution>, 3015 CN Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff55">Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Venturini, Cristina" sort="Venturini, Cristina" uniqKey="Venturini C" first="Cristina" last="Venturini">Cristina Venturini</name><affiliation><nlm:aff id="aff33">Department of Twin Research and Genetic Epidemiology,<institution>King’s College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Vergnaud, Anne Claire" sort="Vergnaud, Anne Claire" uniqKey="Vergnaud A" first="Anne-Claire" last="Vergnaud">Anne-Claire Vergnaud</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation><nlm:aff id="aff56">Department of Cardiology, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="aff57">Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh,<institution>Western General Hospital</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Vuckovic, Dragana" sort="Vuckovic, Dragana" uniqKey="Vuckovic D" first="Dragana" last="Vuckovic">Dragana Vuckovic</name><affiliation><nlm:aff id="aff58">Department of Medical Sciences,<institution>University of Trieste</institution>, 34149 Trieste,<country>Italy</country>;</nlm:aff></affiliation></author><author><name sortKey="Wedenoja, Juho" sort="Wedenoja, Juho" uniqKey="Wedenoja J" first="Juho" last="Wedenoja">Juho Wedenoja</name><affiliation><nlm:aff id="aff30">Department of Public Health,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loic" last="Yengo">Loic Yengo</name><affiliation><nlm:aff id="aff15">CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes,<institution>Lille 2 University</institution>, 59000 Lille,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Yu, Bing" sort="Yu, Bing" uniqKey="Yu B" first="Bing" last="Yu">Bing Yu</name><affiliation><nlm:aff id="aff59">Human Genetics Center,<institution>University of Texas Health Science Center at Houston</institution>, Houston,<addr-line>TX</addr-line> 77225;</nlm:aff></affiliation><affiliation><nlm:aff id="aff60">Division of Epidemiology,<institution>University of Texas Health Science Center at Houston</institution>, Houston,<addr-line>TX</addr-line> 77225;</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff61">Department of Cardiology,<institution>Ealing Hospital</institution>, Middlesex UB1 3HW,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="aff48">Medical Research Council Epidemiology Unit,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="aff25">Department of Biological Psychology,<institution>Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research</institution>, 1081 BT Amsterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Chambers, John" sort="Chambers, John" uniqKey="Chambers J" first="John" last="Chambers">John Chambers</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff61">Department of Cardiology,<institution>Ealing Hospital</institution>, Middlesex UB1 3HW,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff62"><institution>Imperial College Healthcare National Health Service Trust</institution>, London W12 0HS,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="aff47">Division of Preventive Medicine,<institution>Brigham and Women’s Hospital</institution>, Boston,<addr-line>MA</addr-line> 02215;</nlm:aff></affiliation><affiliation><nlm:aff id="aff63"><institution>Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02115;</nlm:aff></affiliation></author><author><name sortKey="Daniela, Toniolo" sort="Daniela, Toniolo" uniqKey="Daniela T" first="Toniolo" last="Daniela">Toniolo Daniela</name><affiliation><nlm:aff id="aff12">Division of Genetics and Cell Biology,<institution>San Raffaele Research Institute</institution>, 20132 Milan,<country>Italy</country>;</nlm:aff></affiliation></author><author><name sortKey="De Geus, Eco" sort="De Geus, Eco" uniqKey="De Geus E" first="Eco" last="De Geus">Eco De Geus</name><affiliation><nlm:aff id="aff25">Department of Biological Psychology,<institution>Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research</institution>, 1081 BT Amsterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Deary, Ian" sort="Deary, Ian" uniqKey="Deary I" first="Ian" last="Deary">Ian Deary</name><affiliation><nlm:aff id="aff20">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff64">Psychology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:aff id="aff27"><institution>National Institute for Health and Welfare</institution>, 00271 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff65">Department of General Practice and Primary Health Care,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff66">Unit of General Practice,<institution>Helsinki University Central Hospital</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff67"><institution>Folkhälsan Research Centre</institution>, Public Health Research, 00290 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff68"><institution>Vasa Central Hospital</institution>, 65130 Vasa,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="aff18">Estonian Genome Center,<institution>University of Tartu</institution>, 51010 Tartu,<country>Estonia</country>;</nlm:aff></affiliation></author><author><name sortKey="Eulenburg, Volker" sort="Eulenburg, Volker" uniqKey="Eulenburg V" first="Volker" last="Eulenburg">Volker Eulenburg</name><affiliation><nlm:aff id="aff69">Institute for Biochemistry and Molecular Medicine,<institution>Friedrich Alexander University Erlangen-Nuremberg</institution>, 91054 Erlangen,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name><affiliation><nlm:aff id="aff55">Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="aff15">CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes,<institution>Lille 2 University</institution>, 59000 Lille,<country>France</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff70">Department of Genomics of Common Disease, School of Public Health,<institution>Imperial College London</institution>, London W12 0HR,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="aff45">Department of Molecular Epidemiology, Institute of Epidemiology II,<institution>Helmholtz Zentrum München</institution>, 85764 Neuherberg,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Grabe, Hans J" sort="Grabe, Hans J" uniqKey="Grabe H" first="Hans J." last="Grabe">Hans J. Grabe</name><affiliation><nlm:aff id="aff71">Department of Psychiatry and Psychotherapy,<institution>University Medicine Greifswald</institution>, 17475 Greifswald,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="aff49"><institution>Research Institute, Icelandic Heart Association</institution>, 201 Kopavogur,<country>Iceland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff72">Faculty of Medicine,<institution>University of Iceland</institution>, 101 Reykjavik,<country>Iceland</country>;</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="aff17">Science for Life Laboratory, Department of Immunology, Genetics and Pathology,<institution>Uppsala University</institution>, 75108 Uppsala,<country>Sweden</country>;</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="aff73">National Institute on Aging,<institution>NIH</institution>, Bethesda,<addr-line>MD</addr-line> 20892;</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="aff74">Department of Obstetrics and Gynecology,<institution>Oulu University Hospital</institution>, 90029 Oulu,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff75">Medical Research Center,<institution>University of Oulu</institution>, 90014 Oulu,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff76">Unit of Primary Care,<institution>Oulu University Hospital</institution>, 90220 Oulu,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C." last="Heath">Andrew C. Heath</name><affiliation><nlm:aff id="aff77">Department of Psychiatry,<institution>Washington University School of Medicine in St. Louis</institution>, St. Louis,<addr-line>MO</addr-line> 63110;</nlm:aff></affiliation></author><author><name sortKey="Hocking, Lynne" sort="Hocking, Lynne" uniqKey="Hocking L" first="Lynne" last="Hocking">Lynne Hocking</name><affiliation><nlm:aff id="aff78">Institute of Medical Sciences,<institution>University of Aberdeen</institution>, Aberdeen AB25 2ZD,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="aff55">Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Huth, Cornelia" sort="Huth, Cornelia" uniqKey="Huth C" first="Cornelia" last="Huth">Cornelia Huth</name><affiliation><nlm:aff id="aff79">Institute of Epidemiology II, Helmholtz Zentrum München,<institution>German Research Center for Environmental Health GmbH</institution>, D-85764 Neuherberg,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff76">Unit of Primary Care,<institution>Oulu University Hospital</institution>, 90220 Oulu,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff80">Center for Life Course Epidemiology, Faculty of Medicine,<institution>University of Oulu</institution>, Oulu FI-90014,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff81">Biocenter Oulu,<institution>University of Oulu</institution>, Oulu FI-90014,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><affiliation><nlm:aff id="aff52">Department of Cardiology,<institution>Leiden University Medical Center</institution>, 2300 RC Leiden,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation><nlm:aff id="aff19">Institute for Molecular Medicine,<institution>University of Helsinki</institution>, 00290 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff27"><institution>National Institute for Health and Welfare</institution>, 00271 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff30">Department of Public Health,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><affiliation><nlm:aff id="aff61">Department of Cardiology,<institution>Ealing Hospital</institution>, Middlesex UB1 3HW,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff62"><institution>Imperial College Healthcare National Health Service Trust</institution>, London W12 0HS,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff82">Faculty of Medicine, National Heart & Lung Institute, Cardiovascular Science, Hammersmith Hospital,<institution>Imperial College London</institution>, London W12 0NN,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name><affiliation><nlm:aff id="aff83">Institute of Social and Preventive Medicine,<institution>Centre Hospitalier Universitaire Vaudoise</institution>, 1010 Lausanne,<country>Switzerland</country>;</nlm:aff></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation><nlm:aff id="aff67"><institution>Folkhälsan Research Centre</institution>, Public Health Research, 00290 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff84">Collegium for Advanced Studies,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff85">Institute of Behavioural Sciences,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="aff31">Medical Research Council Epidemiology Unit, Institute of Metabolic Science,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="aff32">Department of Clinical Chemistry,<institution>Fimlab Laboratories and University of Tampere School of Medicine</institution>, Tampere 33520,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation><nlm:aff id="aff86">Wake Forest School of Medicine, Department of Epidemiology & Prevention, Public Health Sciences,<institution>Wake Forest School of Medicine</institution>, Winston-Salem,<addr-line>NC</addr-line> 27157;</nlm:aff></affiliation></author><author><name sortKey="Madden, Pamela A F" sort="Madden, Pamela A F" uniqKey="Madden P" first="Pamela A. F." last="Madden">Pamela A. F. Madden</name><affiliation><nlm:aff id="aff87"><institution>Department of Psychiatry, Washington University School of Medicine</institution>, St. Louis,<addr-line>MO</addr-line> 63110;</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas" sort="Martin, Nicholas" uniqKey="Martin N" first="Nicholas" last="Martin">Nicholas Martin</name><affiliation><nlm:aff id="aff88">Genetic Epidemiology,<institution>Queensland Institute of Medical Research Berghofer Medical Research Institute</institution>, Herston, Brisbane QLD 4029,<country>Australia</country>;</nlm:aff></affiliation></author><author><name sortKey="Morrison, Alanna" sort="Morrison, Alanna" uniqKey="Morrison A" first="Alanna" last="Morrison">Alanna Morrison</name><affiliation><nlm:aff id="aff59">Human Genetics Center,<institution>University of Texas Health Science Center at Houston</institution>, Houston,<addr-line>TX</addr-line> 77225;</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda" sort="Penninx, Brenda" uniqKey="Penninx B" first="Brenda" last="Penninx">Brenda Penninx</name><affiliation><nlm:aff id="aff37">Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam,<institution>Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest</institution>, 1081 HL Amsterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Pirastu, Nicola" sort="Pirastu, Nicola" uniqKey="Pirastu N" first="Nicola" last="Pirastu">Nicola Pirastu</name><affiliation><nlm:aff id="aff26">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH8 9AG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff58">Department of Medical Sciences,<institution>University of Trieste</institution>, 34149 Trieste,<country>Italy</country>;</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name><affiliation><nlm:aff id="aff29">Cardiovascular Health Research Unit, Department of Medicine,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98101;</nlm:aff></affiliation><affiliation><nlm:aff id="aff89">Department of Epidemiology,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98195;</nlm:aff></affiliation><affiliation><nlm:aff id="aff90">Department of Health Services,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98195;</nlm:aff></affiliation><affiliation><nlm:aff id="aff91">Group Health Cooperative,<institution>Group Health Research Institute</institution>, Seattle,<addr-line>WA</addr-line> 98101;</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation><nlm:aff id="aff92">Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital,<institution>University of Turku</institution>, Turku 20520,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff93">Research Centre of Applied and Preventive Cardiovascular Medicine,<institution>University of Turku</institution>, Turku 20520,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul" sort="Ridker, Paul" uniqKey="Ridker P" first="Paul" last="Ridker">Paul Ridker</name><affiliation><nlm:aff id="aff47">Division of Preventive Medicine,<institution>Brigham and Women’s Hospital</institution>, Boston,<addr-line>MA</addr-line> 02215;</nlm:aff></affiliation><affiliation><nlm:aff id="aff63"><institution>Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02115;</nlm:aff></affiliation></author><author><name sortKey="Rose, Richard" sort="Rose, Richard" uniqKey="Rose R" first="Richard" last="Rose">Richard Rose</name><affiliation><nlm:aff id="aff94">Department of Psychological and Brain Sciences,<institution>Indiana University</institution>, Bloomington,<addr-line>IN</addr-line> 47405;</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="aff95">Institute for Translational Genomics and Population Sciences,<institution>Los Angeles Biomedical Research Institute at Harbor–University of California, Los Angeles Medical Center</institution>, Torrance,<addr-line>CA</addr-line> 90509;</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><affiliation><nlm:aff id="aff41">Department of Cardiovascular Sciences, University of Leicester,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff42">National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation><nlm:aff id="aff96">Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine,<institution>Medical University of Graz</institution>, 8010 Graz,<country>Austria</country>;</nlm:aff></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation><nlm:aff id="aff33">Department of Twin Research and Genetic Epidemiology,<institution>King’s College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Stott, David" sort="Stott, David" uniqKey="Stott D" first="David" last="Stott">David Stott</name><affiliation><nlm:aff id="aff97">Institute of Cardiovascular and Medical Sciences, Faculty of Medicine,<institution>University of Glasgow</institution>, Glasgow G31 2ER,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Strachan, David" sort="Strachan, David" uniqKey="Strachan D" first="David" last="Strachan">David Strachan</name><affiliation><nlm:aff id="aff98">Population Health Research Institute, St. George's,<institution>University of London</institution>, London SW17 0RE,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Tzoulaki, Ioanna" sort="Tzoulaki, Ioanna" uniqKey="Tzoulaki I" first="Ioanna" last="Tzoulaki">Ioanna Tzoulaki</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff6">Medical Research Council-Public Health England Centre for Environment and Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff99">Department of Hygiene and Epidemiology,<institution>University of Ioannina Medical School</institution>, 45110 Ioannina,<country>Greece</country>;</nlm:aff></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:aff id="aff56">Department of Cardiology, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff100">Department of Genetics, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff101">Durrer Center for Cardiogenetic Research,<institution>Interuniversity Cardiology Institute of The Netherlands–Netherlands Heart Institute</institution>, 3511GC Utrecht,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="aff9">Genetic Epidemiology Unit, Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name><affiliation><nlm:aff id="aff102">Department of Medicine, Internal Medicine,<institution>Lausanne University Hospital</institution>, 1011 Lausanne,<country>Switzerland</country>;</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="aff102">Department of Medicine, Internal Medicine,<institution>Lausanne University Hospital</institution>, 1011 Lausanne,<country>Switzerland</country>;</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="aff48">Medical Research Council Epidemiology Unit,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name><affiliation><nlm:aff id="aff88">Genetic Epidemiology,<institution>Queensland Institute of Medical Research Berghofer Medical Research Institute</institution>, Herston, Brisbane QLD 4029,<country>Australia</country>;</nlm:aff></affiliation></author><author><name sortKey="Wilson, James" sort="Wilson, James" uniqKey="Wilson J" first="James" last="Wilson">James Wilson</name><affiliation><nlm:aff id="aff26">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH8 9AG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff57">Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh,<institution>Western General Hospital</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce" sort="Wolffenbuttel, Bruce" uniqKey="Wolffenbuttel B" first="Bruce" last="Wolffenbuttel">Bruce Wolffenbuttel</name><affiliation><nlm:aff id="aff103">Department of Endocrinology, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Bakalkin, Georgy" sort="Bakalkin, Georgy" uniqKey="Bakalkin G" first="Georgy" last="Bakalkin">Georgy Bakalkin</name><affiliation><nlm:aff id="aff104">Division of Biological Research on Drug Dependence, Department of Pharmaceutical, Biosciences,<institution>Uppsala University</institution>, 751 24 Uppsala,<country>Sweden</country>;</nlm:aff></affiliation></author><author><name sortKey="Evangelou, Evangelos" sort="Evangelou, Evangelos" uniqKey="Evangelou E" first="Evangelos" last="Evangelou">Evangelos Evangelou</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff99">Department of Hygiene and Epidemiology,<institution>University of Ioannina Medical School</institution>, 45110 Ioannina,<country>Greece</country>;</nlm:aff></affiliation></author><author><name sortKey="Liu, Yun" sort="Liu, Yun" uniqKey="Liu Y" first="Yun" last="Liu">Yun Liu</name><affiliation><nlm:aff id="aff105">Key Laboratory of Metabolism and Molecular Medicine,<institution>Ministry of Education</institution>, 200032 Shanghai,<country>People’s Republic of China</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff106">Department of Biochemistry and Molecular Biology,<institution>Fudan University Shanghai Medical College</institution>, 200032 Shanghai,<country>People’s Republic of China</country>;</nlm:aff></affiliation></author><author><name sortKey="Rice, Kenneth M" sort="Rice, Kenneth M" uniqKey="Rice K" first="Kenneth M." last="Rice">Kenneth M. Rice</name><affiliation><nlm:aff id="aff107">Department of Biostatistics,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98195;</nlm:aff></affiliation></author><author><name sortKey="Desrivieres, Sylvane" sort="Desrivieres, Sylvane" uniqKey="Desrivieres S" first="Sylvane" last="Desrivières">Sylvane Desrivières</name><affiliation><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Kliewer, Steven A" sort="Kliewer, Steven A" uniqKey="Kliewer S" first="Steven A." last="Kliewer">Steven A. Kliewer</name><affiliation><nlm:aff id="aff7">Department of Pharmacology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation><affiliation><nlm:aff id="aff108">Department of Molecular Biology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390</nlm:aff></affiliation></author><author><name sortKey="Mangelsdorf, David J" sort="Mangelsdorf, David J" uniqKey="Mangelsdorf D" first="David J." last="Mangelsdorf">David J. Mangelsdorf</name><affiliation><nlm:aff id="aff7">Department of Pharmacology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation><affiliation><nlm:aff id="aff8"><institution>Howard Hughes Medical Institute</institution>,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation></author><author><name sortKey="Muller, Christian P" sort="Muller, Christian P" uniqKey="Muller C" first="Christian P." last="Müller">Christian P. Müller</name><affiliation><nlm:aff id="aff22">Department of Psychiatry and Psychotherapy,<institution>Friedrich Alexander University Erlangen-Nuremberg</institution>, 91054 Erlangen,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name><affiliation><nlm:aff id="aff2"><institution>The Framingham Heart Study</institution>, Framingham,<addr-line>MA</addr-line> 01702;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">The Population Sciences Branch, Division of Intramural Research,<institution>National Heart, Lung, and Blood Institute</institution>, Bethesda,<addr-line>MD</addr-line> 20824;</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff6">Medical Research Council-Public Health England Centre for Environment and Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27911795</idno><idno type="pmc">5167198</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167198</idno><idno type="RBID">PMC:5167198</idno><idno type="doi">10.1073/pnas.1611243113</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001C11</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C11</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>KLB</italic> is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference</title><author><name sortKey="Schumann, Gunter" sort="Schumann, Gunter" uniqKey="Schumann G" first="Gunter" last="Schumann">Gunter Schumann</name><affiliation><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Liu, Chunyu" sort="Liu, Chunyu" uniqKey="Liu C" first="Chunyu" last="Liu">Chunyu Liu</name><affiliation><nlm:aff id="aff2"><institution>The Framingham Heart Study</institution>, Framingham,<addr-line>MA</addr-line> 01702;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">The Population Sciences Branch, Division of Intramural Research,<institution>National Heart, Lung, and Blood Institute</institution>, Bethesda,<addr-line>MD</addr-line> 20824;</nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>Department of Biostatistics, Boston University School of Public Health</institution>, Boston,<addr-line>MA</addr-line> 02118;</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Paul" sort="O Eilly, Paul" uniqKey="O Eilly P" first="Paul" last="O Eilly">Paul O Eilly</name><affiliation><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Gao, He" sort="Gao, He" uniqKey="Gao H" first="He" last="Gao">He Gao</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff6">Medical Research Council-Public Health England Centre for Environment and Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Song, Parkyong" sort="Song, Parkyong" uniqKey="Song P" first="Parkyong" last="Song">Parkyong Song</name><affiliation><nlm:aff id="aff7">Department of Pharmacology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation><affiliation><nlm:aff id="aff8"><institution>Howard Hughes Medical Institute</institution>,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation></author><author><name sortKey="Xu, Bing" sort="Xu, Bing" uniqKey="Xu B" first="Bing" last="Xu">Bing Xu</name><affiliation><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Ruggeri, Barbara" sort="Ruggeri, Barbara" uniqKey="Ruggeri B" first="Barbara" last="Ruggeri">Barbara Ruggeri</name><affiliation><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:aff id="aff9">Genetic Epidemiology Unit, Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Jia, Tianye" sort="Jia, Tianye" uniqKey="Jia T" first="Tianye" last="Jia">Tianye Jia</name><affiliation><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Preis, Sarah" sort="Preis, Sarah" uniqKey="Preis S" first="Sarah" last="Preis">Sarah Preis</name><affiliation><nlm:aff id="aff4"><institution>Department of Biostatistics, Boston University School of Public Health</institution>, Boston,<addr-line>MA</addr-line> 02118;</nlm:aff></affiliation></author><author><name sortKey="Segura Lepe, Marcelo" sort="Segura Lepe, Marcelo" uniqKey="Segura Lepe M" first="Marcelo" last="Segura Lepe">Marcelo Segura Lepe</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff10"><institution>Section of Bioinformatics, Bayer Pharma AG</institution>, 13342 Berlin,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Akira, Shizuo" sort="Akira, Shizuo" uniqKey="Akira S" first="Shizuo" last="Akira">Shizuo Akira</name><affiliation><nlm:aff id="aff11">Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases,<institution>Osaka University</institution>, Osaka 565-0871,<country>Japan</country>;</nlm:aff></affiliation></author><author><name sortKey="Barbieri, Caterina" sort="Barbieri, Caterina" uniqKey="Barbieri C" first="Caterina" last="Barbieri">Caterina Barbieri</name><affiliation><nlm:aff id="aff12">Division of Genetics and Cell Biology,<institution>San Raffaele Research Institute</institution>, 20132 Milan,<country>Italy</country>;</nlm:aff></affiliation></author><author><name sortKey="Baumeister, Sebastian" sort="Baumeister, Sebastian" uniqKey="Baumeister S" first="Sebastian" last="Baumeister">Sebastian Baumeister</name><affiliation><nlm:aff id="aff13">Institute for Community Medicine,<institution>University Medicine Greifswald</institution>, Greifswald 17475,<country>Germany</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">Department of Epidemiology and Preventive Medicine,<institution>University of Regensburg</institution>, 93053 Regensburg,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Cauchi, Stephane" sort="Cauchi, Stephane" uniqKey="Cauchi S" first="Stephane" last="Cauchi">Stephane Cauchi</name><affiliation><nlm:aff id="aff15">CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes,<institution>Lille 2 University</institution>, 59000 Lille,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Clarke, Toni Kim" sort="Clarke, Toni Kim" uniqKey="Clarke T" first="Toni-Kim" last="Clarke">Toni-Kim Clarke</name><affiliation><nlm:aff id="aff16">Divison of Psychiatry,<institution>University of Edinburgh</institution>, Edinburgh EH10 5HF,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Enroth, Stefan" sort="Enroth, Stefan" uniqKey="Enroth S" first="Stefan" last="Enroth">Stefan Enroth</name><affiliation><nlm:aff id="aff17">Science for Life Laboratory, Department of Immunology, Genetics and Pathology,<institution>Uppsala University</institution>, 75108 Uppsala,<country>Sweden</country>;</nlm:aff></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation><nlm:aff id="aff18">Estonian Genome Center,<institution>University of Tartu</institution>, 51010 Tartu,<country>Estonia</country>;</nlm:aff></affiliation></author><author><name sortKey="H Llfors, Jenni" sort="H Llfors, Jenni" uniqKey="H Llfors J" first="Jenni" last="H Llfors">Jenni H Llfors</name><affiliation><nlm:aff id="aff19">Institute for Molecular Medicine,<institution>University of Helsinki</institution>, 00290 Helsinki,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Harris, Sarah E" sort="Harris, Sarah E" uniqKey="Harris S" first="Sarah E." last="Harris">Sarah E. Harris</name><affiliation><nlm:aff id="aff20">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff21">Centre for Genomic and Experimental Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Hieber, Saskia" sort="Hieber, Saskia" uniqKey="Hieber S" first="Saskia" last="Hieber">Saskia Hieber</name><affiliation><nlm:aff id="aff22">Department of Psychiatry and Psychotherapy,<institution>Friedrich Alexander University Erlangen-Nuremberg</institution>, 91054 Erlangen,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Hofer, Edith" sort="Hofer, Edith" uniqKey="Hofer E" first="Edith" last="Hofer">Edith Hofer</name><affiliation><nlm:aff id="aff23">Clinical Division of Neurogeriatrics, Department of Neurology,<institution>Medical University Graz</institution>, 8036 Graz,<country>Austria</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff24">Institute of Medical Informatics, Statistics and Documentation,<institution>Medical University Graz</institution>, 8036 Graz,<country>Austria</country>;</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="aff25">Department of Biological Psychology,<institution>Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research</institution>, 1081 BT Amsterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="aff17">Science for Life Laboratory, Department of Immunology, Genetics and Pathology,<institution>Uppsala University</institution>, 75108 Uppsala,<country>Sweden</country>;</nlm:aff></affiliation></author><author><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K." last="Joshi">Peter K. Joshi</name><affiliation><nlm:aff id="aff26">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH8 9AG,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Kaartinen, Niina" sort="Kaartinen, Niina" uniqKey="Kaartinen N" first="Niina" last="Kaartinen">Niina Kaartinen</name><affiliation><nlm:aff id="aff27"><institution>National Institute for Health and Welfare</institution>, 00271 Helsinki,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><affiliation><nlm:aff id="aff28"><institution>Quantified Employee-Unit, Finnish Institute of Occupational Health</institution>, 00250 Helsinki,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Lemaitre, Rozenn" sort="Lemaitre, Rozenn" uniqKey="Lemaitre R" first="Rozenn" last="Lemaitre">Rozenn Lemaitre</name><affiliation><nlm:aff id="aff29">Cardiovascular Health Research Unit, Department of Medicine,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98101;</nlm:aff></affiliation></author><author><name sortKey="Loukola, Anu" sort="Loukola, Anu" uniqKey="Loukola A" first="Anu" last="Loukola">Anu Loukola</name><affiliation><nlm:aff id="aff19">Institute for Molecular Medicine,<institution>University of Helsinki</institution>, 00290 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff30">Department of Public Health,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation><nlm:aff id="aff31">Medical Research Council Epidemiology Unit, Institute of Metabolic Science,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation><nlm:aff id="aff32">Department of Clinical Chemistry,<institution>Fimlab Laboratories and University of Tampere School of Medicine</institution>, Tampere 33520,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="aff33">Department of Twin Research and Genetic Epidemiology,<institution>King’s College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff34"><institution>National Institute for Health Research Biomedical Research Centre at Guy’s and St. Thomas’ Foundation Trust</institution>, London SE1 9RT, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Manichaikul, Ani" sort="Manichaikul, Ani" uniqKey="Manichaikul A" first="Ani" last="Manichaikul">Ani Manichaikul</name><affiliation><nlm:aff id="aff35">Center for Public Health Genomics, Department of Public Health Sciences,<institution>University of Virginia</institution>, Charlottesville,<addr-line>VA</addr-line> 22903;</nlm:aff></affiliation><affiliation><nlm:aff id="aff36">Biostatistics Section, Department of Public Health Sciences,<institution>University of Virginia</institution>, Charlottesville,<addr-line>VA</addr-line> 22903;</nlm:aff></affiliation></author><author><name sortKey="Mbarek, Hamdi" sort="Mbarek, Hamdi" uniqKey="Mbarek H" first="Hamdi" last="Mbarek">Hamdi Mbarek</name><affiliation><nlm:aff id="aff25">Department of Biological Psychology,<institution>Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research</institution>, 1081 BT Amsterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Milaneschi, Yuri" sort="Milaneschi, Yuri" uniqKey="Milaneschi Y" first="Yuri" last="Milaneschi">Yuri Milaneschi</name><affiliation><nlm:aff id="aff37">Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam,<institution>Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest</institution>, 1081 HL Amsterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Moayyeri, Alireza" sort="Moayyeri, Alireza" uniqKey="Moayyeri A" first="Alireza" last="Moayyeri">Alireza Moayyeri</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff38">Institute of Health Informatics,<institution>University College London</institution>, London NW1 2DA,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff39"><institution>Farr Institute of Health Informatics Research</institution>, University College London Institute of Health Informatics, London NW1 2DA,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Mukamal, Kenneth" sort="Mukamal, Kenneth" uniqKey="Mukamal K" first="Kenneth" last="Mukamal">Kenneth Mukamal</name><affiliation><nlm:aff id="aff40">Department of Medicine,<institution>Beth Israel Deaconess Medical Center and Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02215;</nlm:aff></affiliation></author><author><name sortKey="Nelson, Christopher" sort="Nelson, Christopher" uniqKey="Nelson C" first="Christopher" last="Nelson">Christopher Nelson</name><affiliation><nlm:aff id="aff41">Department of Cardiovascular Sciences, University of Leicester,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff42">National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Nettleton, Jennifer" sort="Nettleton, Jennifer" uniqKey="Nettleton J" first="Jennifer" last="Nettleton">Jennifer Nettleton</name><affiliation><nlm:aff id="aff43">Division of Epidemiology, Human Genetics, and Environmental Sciences,<institution>University of Texas Health Sciences Center</institution>, Houston,<addr-line>TX</addr-line> 77225;</nlm:aff></affiliation></author><author><name sortKey="Partinen, Eemil" sort="Partinen, Eemil" uniqKey="Partinen E" first="Eemil" last="Partinen">Eemil Partinen</name><affiliation><nlm:aff id="aff44">Faculty of Medicine,<institution>University of Tartu</institution>, 50411 Tartu,<country>Estonia</country>;</nlm:aff></affiliation></author><author><name sortKey="Rawal, Rajesh" sort="Rawal, Rajesh" uniqKey="Rawal R" first="Rajesh" last="Rawal">Rajesh Rawal</name><affiliation><nlm:aff id="aff45">Department of Molecular Epidemiology, Institute of Epidemiology II,<institution>Helmholtz Zentrum München</institution>, 85764 Neuherberg,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><affiliation><nlm:aff id="aff46"><institution>Institute for Maternal and Child Health—Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo</institution>, 34137 Trieste,<country>Italy</country>;</nlm:aff></affiliation></author><author><name sortKey="Rose, Lynda" sort="Rose, Lynda" uniqKey="Rose L" first="Lynda" last="Rose">Lynda Rose</name><affiliation><nlm:aff id="aff47">Division of Preventive Medicine,<institution>Brigham and Women’s Hospital</institution>, Boston,<addr-line>MA</addr-line> 02215;</nlm:aff></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation><nlm:aff id="aff12">Division of Genetics and Cell Biology,<institution>San Raffaele Research Institute</institution>, 20132 Milan,<country>Italy</country>;</nlm:aff></affiliation></author><author><name sortKey="Satoh, Takashi" sort="Satoh, Takashi" uniqKey="Satoh T" first="Takashi" last="Satoh">Takashi Satoh</name><affiliation><nlm:aff id="aff11">Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases,<institution>Osaka University</institution>, Osaka 565-0871,<country>Japan</country>;</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation><nlm:aff id="aff23">Clinical Division of Neurogeriatrics, Department of Neurology,<institution>Medical University Graz</institution>, 8036 Graz,<country>Austria</country>;</nlm:aff></affiliation></author><author><name sortKey="Schraut, Katharina" sort="Schraut, Katharina" uniqKey="Schraut K" first="Katharina" last="Schraut">Katharina Schraut</name><affiliation><nlm:aff id="aff26">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH8 9AG,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Scott, Robert" sort="Scott, Robert" uniqKey="Scott R" first="Robert" last="Scott">Robert Scott</name><affiliation><nlm:aff id="aff48">Medical Research Council Epidemiology Unit,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation><nlm:aff id="aff49"><institution>Research Institute, Icelandic Heart Association</institution>, 201 Kopavogur,<country>Iceland</country>;</nlm:aff></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation><nlm:aff id="aff20">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff50">Alzheimer Scotland Research Centre,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="aff13">Institute for Community Medicine,<institution>University Medicine Greifswald</institution>, Greifswald 17475,<country>Germany</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff51">Interfaculty Institute for Genetics and Functional Genomics,<institution>University Medicine Greifswald</institution>, 17475 Greifswald,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation><nlm:aff id="aff52">Department of Cardiology,<institution>Leiden University Medical Center</institution>, 2300 RC Leiden,<country>The Netherlands</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff53">Department of Gerontology and Geriatrics,<institution>Leiden University Medical Center</institution>, 2300 RC Leiden,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation><nlm:aff id="aff54">Department of internal Medicine,<institution>Erasmus Medical Center</institution>, 3015 CN Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff55">Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Venturini, Cristina" sort="Venturini, Cristina" uniqKey="Venturini C" first="Cristina" last="Venturini">Cristina Venturini</name><affiliation><nlm:aff id="aff33">Department of Twin Research and Genetic Epidemiology,<institution>King’s College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Vergnaud, Anne Claire" sort="Vergnaud, Anne Claire" uniqKey="Vergnaud A" first="Anne-Claire" last="Vergnaud">Anne-Claire Vergnaud</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation><nlm:aff id="aff56">Department of Cardiology, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="aff57">Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh,<institution>Western General Hospital</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Vuckovic, Dragana" sort="Vuckovic, Dragana" uniqKey="Vuckovic D" first="Dragana" last="Vuckovic">Dragana Vuckovic</name><affiliation><nlm:aff id="aff58">Department of Medical Sciences,<institution>University of Trieste</institution>, 34149 Trieste,<country>Italy</country>;</nlm:aff></affiliation></author><author><name sortKey="Wedenoja, Juho" sort="Wedenoja, Juho" uniqKey="Wedenoja J" first="Juho" last="Wedenoja">Juho Wedenoja</name><affiliation><nlm:aff id="aff30">Department of Public Health,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loic" last="Yengo">Loic Yengo</name><affiliation><nlm:aff id="aff15">CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes,<institution>Lille 2 University</institution>, 59000 Lille,<country>France</country>;</nlm:aff></affiliation></author><author><name sortKey="Yu, Bing" sort="Yu, Bing" uniqKey="Yu B" first="Bing" last="Yu">Bing Yu</name><affiliation><nlm:aff id="aff59">Human Genetics Center,<institution>University of Texas Health Science Center at Houston</institution>, Houston,<addr-line>TX</addr-line> 77225;</nlm:aff></affiliation><affiliation><nlm:aff id="aff60">Division of Epidemiology,<institution>University of Texas Health Science Center at Houston</institution>, Houston,<addr-line>TX</addr-line> 77225;</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff61">Department of Cardiology,<institution>Ealing Hospital</institution>, Middlesex UB1 3HW,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="aff48">Medical Research Council Epidemiology Unit,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="aff25">Department of Biological Psychology,<institution>Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research</institution>, 1081 BT Amsterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Chambers, John" sort="Chambers, John" uniqKey="Chambers J" first="John" last="Chambers">John Chambers</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff61">Department of Cardiology,<institution>Ealing Hospital</institution>, Middlesex UB1 3HW,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff62"><institution>Imperial College Healthcare National Health Service Trust</institution>, London W12 0HS,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="aff47">Division of Preventive Medicine,<institution>Brigham and Women’s Hospital</institution>, Boston,<addr-line>MA</addr-line> 02215;</nlm:aff></affiliation><affiliation><nlm:aff id="aff63"><institution>Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02115;</nlm:aff></affiliation></author><author><name sortKey="Daniela, Toniolo" sort="Daniela, Toniolo" uniqKey="Daniela T" first="Toniolo" last="Daniela">Toniolo Daniela</name><affiliation><nlm:aff id="aff12">Division of Genetics and Cell Biology,<institution>San Raffaele Research Institute</institution>, 20132 Milan,<country>Italy</country>;</nlm:aff></affiliation></author><author><name sortKey="De Geus, Eco" sort="De Geus, Eco" uniqKey="De Geus E" first="Eco" last="De Geus">Eco De Geus</name><affiliation><nlm:aff id="aff25">Department of Biological Psychology,<institution>Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research</institution>, 1081 BT Amsterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Deary, Ian" sort="Deary, Ian" uniqKey="Deary I" first="Ian" last="Deary">Ian Deary</name><affiliation><nlm:aff id="aff20">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff64">Psychology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:aff id="aff27"><institution>National Institute for Health and Welfare</institution>, 00271 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff65">Department of General Practice and Primary Health Care,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff66">Unit of General Practice,<institution>Helsinki University Central Hospital</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff67"><institution>Folkhälsan Research Centre</institution>, Public Health Research, 00290 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff68"><institution>Vasa Central Hospital</institution>, 65130 Vasa,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="aff18">Estonian Genome Center,<institution>University of Tartu</institution>, 51010 Tartu,<country>Estonia</country>;</nlm:aff></affiliation></author><author><name sortKey="Eulenburg, Volker" sort="Eulenburg, Volker" uniqKey="Eulenburg V" first="Volker" last="Eulenburg">Volker Eulenburg</name><affiliation><nlm:aff id="aff69">Institute for Biochemistry and Molecular Medicine,<institution>Friedrich Alexander University Erlangen-Nuremberg</institution>, 91054 Erlangen,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name><affiliation><nlm:aff id="aff55">Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="aff15">CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes,<institution>Lille 2 University</institution>, 59000 Lille,<country>France</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff70">Department of Genomics of Common Disease, School of Public Health,<institution>Imperial College London</institution>, London W12 0HR,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="aff45">Department of Molecular Epidemiology, Institute of Epidemiology II,<institution>Helmholtz Zentrum München</institution>, 85764 Neuherberg,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Grabe, Hans J" sort="Grabe, Hans J" uniqKey="Grabe H" first="Hans J." last="Grabe">Hans J. Grabe</name><affiliation><nlm:aff id="aff71">Department of Psychiatry and Psychotherapy,<institution>University Medicine Greifswald</institution>, 17475 Greifswald,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="aff49"><institution>Research Institute, Icelandic Heart Association</institution>, 201 Kopavogur,<country>Iceland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff72">Faculty of Medicine,<institution>University of Iceland</institution>, 101 Reykjavik,<country>Iceland</country>;</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="aff17">Science for Life Laboratory, Department of Immunology, Genetics and Pathology,<institution>Uppsala University</institution>, 75108 Uppsala,<country>Sweden</country>;</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="aff73">National Institute on Aging,<institution>NIH</institution>, Bethesda,<addr-line>MD</addr-line> 20892;</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="aff74">Department of Obstetrics and Gynecology,<institution>Oulu University Hospital</institution>, 90029 Oulu,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff75">Medical Research Center,<institution>University of Oulu</institution>, 90014 Oulu,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff76">Unit of Primary Care,<institution>Oulu University Hospital</institution>, 90220 Oulu,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C." last="Heath">Andrew C. Heath</name><affiliation><nlm:aff id="aff77">Department of Psychiatry,<institution>Washington University School of Medicine in St. Louis</institution>, St. Louis,<addr-line>MO</addr-line> 63110;</nlm:aff></affiliation></author><author><name sortKey="Hocking, Lynne" sort="Hocking, Lynne" uniqKey="Hocking L" first="Lynne" last="Hocking">Lynne Hocking</name><affiliation><nlm:aff id="aff78">Institute of Medical Sciences,<institution>University of Aberdeen</institution>, Aberdeen AB25 2ZD,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="aff55">Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Huth, Cornelia" sort="Huth, Cornelia" uniqKey="Huth C" first="Cornelia" last="Huth">Cornelia Huth</name><affiliation><nlm:aff id="aff79">Institute of Epidemiology II, Helmholtz Zentrum München,<institution>German Research Center for Environmental Health GmbH</institution>, D-85764 Neuherberg,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff76">Unit of Primary Care,<institution>Oulu University Hospital</institution>, 90220 Oulu,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff80">Center for Life Course Epidemiology, Faculty of Medicine,<institution>University of Oulu</institution>, Oulu FI-90014,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff81">Biocenter Oulu,<institution>University of Oulu</institution>, Oulu FI-90014,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><affiliation><nlm:aff id="aff52">Department of Cardiology,<institution>Leiden University Medical Center</institution>, 2300 RC Leiden,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation><nlm:aff id="aff19">Institute for Molecular Medicine,<institution>University of Helsinki</institution>, 00290 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff27"><institution>National Institute for Health and Welfare</institution>, 00271 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff30">Department of Public Health,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><affiliation><nlm:aff id="aff61">Department of Cardiology,<institution>Ealing Hospital</institution>, Middlesex UB1 3HW,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff62"><institution>Imperial College Healthcare National Health Service Trust</institution>, London W12 0HS,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff82">Faculty of Medicine, National Heart & Lung Institute, Cardiovascular Science, Hammersmith Hospital,<institution>Imperial College London</institution>, London W12 0NN,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name><affiliation><nlm:aff id="aff83">Institute of Social and Preventive Medicine,<institution>Centre Hospitalier Universitaire Vaudoise</institution>, 1010 Lausanne,<country>Switzerland</country>;</nlm:aff></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation><nlm:aff id="aff67"><institution>Folkhälsan Research Centre</institution>, Public Health Research, 00290 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff84">Collegium for Advanced Studies,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff85">Institute of Behavioural Sciences,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="aff31">Medical Research Council Epidemiology Unit, Institute of Metabolic Science,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="aff32">Department of Clinical Chemistry,<institution>Fimlab Laboratories and University of Tampere School of Medicine</institution>, Tampere 33520,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation><nlm:aff id="aff86">Wake Forest School of Medicine, Department of Epidemiology & Prevention, Public Health Sciences,<institution>Wake Forest School of Medicine</institution>, Winston-Salem,<addr-line>NC</addr-line> 27157;</nlm:aff></affiliation></author><author><name sortKey="Madden, Pamela A F" sort="Madden, Pamela A F" uniqKey="Madden P" first="Pamela A. F." last="Madden">Pamela A. F. Madden</name><affiliation><nlm:aff id="aff87"><institution>Department of Psychiatry, Washington University School of Medicine</institution>, St. Louis,<addr-line>MO</addr-line> 63110;</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas" sort="Martin, Nicholas" uniqKey="Martin N" first="Nicholas" last="Martin">Nicholas Martin</name><affiliation><nlm:aff id="aff88">Genetic Epidemiology,<institution>Queensland Institute of Medical Research Berghofer Medical Research Institute</institution>, Herston, Brisbane QLD 4029,<country>Australia</country>;</nlm:aff></affiliation></author><author><name sortKey="Morrison, Alanna" sort="Morrison, Alanna" uniqKey="Morrison A" first="Alanna" last="Morrison">Alanna Morrison</name><affiliation><nlm:aff id="aff59">Human Genetics Center,<institution>University of Texas Health Science Center at Houston</institution>, Houston,<addr-line>TX</addr-line> 77225;</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda" sort="Penninx, Brenda" uniqKey="Penninx B" first="Brenda" last="Penninx">Brenda Penninx</name><affiliation><nlm:aff id="aff37">Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam,<institution>Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest</institution>, 1081 HL Amsterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Pirastu, Nicola" sort="Pirastu, Nicola" uniqKey="Pirastu N" first="Nicola" last="Pirastu">Nicola Pirastu</name><affiliation><nlm:aff id="aff26">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH8 9AG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff58">Department of Medical Sciences,<institution>University of Trieste</institution>, 34149 Trieste,<country>Italy</country>;</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name><affiliation><nlm:aff id="aff29">Cardiovascular Health Research Unit, Department of Medicine,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98101;</nlm:aff></affiliation><affiliation><nlm:aff id="aff89">Department of Epidemiology,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98195;</nlm:aff></affiliation><affiliation><nlm:aff id="aff90">Department of Health Services,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98195;</nlm:aff></affiliation><affiliation><nlm:aff id="aff91">Group Health Cooperative,<institution>Group Health Research Institute</institution>, Seattle,<addr-line>WA</addr-line> 98101;</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation><nlm:aff id="aff92">Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital,<institution>University of Turku</institution>, Turku 20520,<country>Finland</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff93">Research Centre of Applied and Preventive Cardiovascular Medicine,<institution>University of Turku</institution>, Turku 20520,<country>Finland</country>;</nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul" sort="Ridker, Paul" uniqKey="Ridker P" first="Paul" last="Ridker">Paul Ridker</name><affiliation><nlm:aff id="aff47">Division of Preventive Medicine,<institution>Brigham and Women’s Hospital</institution>, Boston,<addr-line>MA</addr-line> 02215;</nlm:aff></affiliation><affiliation><nlm:aff id="aff63"><institution>Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02115;</nlm:aff></affiliation></author><author><name sortKey="Rose, Richard" sort="Rose, Richard" uniqKey="Rose R" first="Richard" last="Rose">Richard Rose</name><affiliation><nlm:aff id="aff94">Department of Psychological and Brain Sciences,<institution>Indiana University</institution>, Bloomington,<addr-line>IN</addr-line> 47405;</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="aff95">Institute for Translational Genomics and Population Sciences,<institution>Los Angeles Biomedical Research Institute at Harbor–University of California, Los Angeles Medical Center</institution>, Torrance,<addr-line>CA</addr-line> 90509;</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><affiliation><nlm:aff id="aff41">Department of Cardiovascular Sciences, University of Leicester,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff42">National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation><nlm:aff id="aff96">Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine,<institution>Medical University of Graz</institution>, 8010 Graz,<country>Austria</country>;</nlm:aff></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation><nlm:aff id="aff33">Department of Twin Research and Genetic Epidemiology,<institution>King’s College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Stott, David" sort="Stott, David" uniqKey="Stott D" first="David" last="Stott">David Stott</name><affiliation><nlm:aff id="aff97">Institute of Cardiovascular and Medical Sciences, Faculty of Medicine,<institution>University of Glasgow</institution>, Glasgow G31 2ER,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Strachan, David" sort="Strachan, David" uniqKey="Strachan D" first="David" last="Strachan">David Strachan</name><affiliation><nlm:aff id="aff98">Population Health Research Institute, St. George's,<institution>University of London</institution>, London SW17 0RE,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Tzoulaki, Ioanna" sort="Tzoulaki, Ioanna" uniqKey="Tzoulaki I" first="Ioanna" last="Tzoulaki">Ioanna Tzoulaki</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff6">Medical Research Council-Public Health England Centre for Environment and Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff99">Department of Hygiene and Epidemiology,<institution>University of Ioannina Medical School</institution>, 45110 Ioannina,<country>Greece</country>;</nlm:aff></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:aff id="aff56">Department of Cardiology, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff100">Department of Genetics, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff101">Durrer Center for Cardiogenetic Research,<institution>Interuniversity Cardiology Institute of The Netherlands–Netherlands Heart Institute</institution>, 3511GC Utrecht,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="aff9">Genetic Epidemiology Unit, Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name><affiliation><nlm:aff id="aff102">Department of Medicine, Internal Medicine,<institution>Lausanne University Hospital</institution>, 1011 Lausanne,<country>Switzerland</country>;</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="aff102">Department of Medicine, Internal Medicine,<institution>Lausanne University Hospital</institution>, 1011 Lausanne,<country>Switzerland</country>;</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="aff48">Medical Research Council Epidemiology Unit,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name><affiliation><nlm:aff id="aff88">Genetic Epidemiology,<institution>Queensland Institute of Medical Research Berghofer Medical Research Institute</institution>, Herston, Brisbane QLD 4029,<country>Australia</country>;</nlm:aff></affiliation></author><author><name sortKey="Wilson, James" sort="Wilson, James" uniqKey="Wilson J" first="James" last="Wilson">James Wilson</name><affiliation><nlm:aff id="aff26">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH8 9AG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff57">Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh,<institution>Western General Hospital</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce" sort="Wolffenbuttel, Bruce" uniqKey="Wolffenbuttel B" first="Bruce" last="Wolffenbuttel">Bruce Wolffenbuttel</name><affiliation><nlm:aff id="aff103">Department of Endocrinology, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Bakalkin, Georgy" sort="Bakalkin, Georgy" uniqKey="Bakalkin G" first="Georgy" last="Bakalkin">Georgy Bakalkin</name><affiliation><nlm:aff id="aff104">Division of Biological Research on Drug Dependence, Department of Pharmaceutical, Biosciences,<institution>Uppsala University</institution>, 751 24 Uppsala,<country>Sweden</country>;</nlm:aff></affiliation></author><author><name sortKey="Evangelou, Evangelos" sort="Evangelou, Evangelos" uniqKey="Evangelou E" first="Evangelos" last="Evangelou">Evangelos Evangelou</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff99">Department of Hygiene and Epidemiology,<institution>University of Ioannina Medical School</institution>, 45110 Ioannina,<country>Greece</country>;</nlm:aff></affiliation></author><author><name sortKey="Liu, Yun" sort="Liu, Yun" uniqKey="Liu Y" first="Yun" last="Liu">Yun Liu</name><affiliation><nlm:aff id="aff105">Key Laboratory of Metabolism and Molecular Medicine,<institution>Ministry of Education</institution>, 200032 Shanghai,<country>People’s Republic of China</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff106">Department of Biochemistry and Molecular Biology,<institution>Fudan University Shanghai Medical College</institution>, 200032 Shanghai,<country>People’s Republic of China</country>;</nlm:aff></affiliation></author><author><name sortKey="Rice, Kenneth M" sort="Rice, Kenneth M" uniqKey="Rice K" first="Kenneth M." last="Rice">Kenneth M. Rice</name><affiliation><nlm:aff id="aff107">Department of Biostatistics,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98195;</nlm:aff></affiliation></author><author><name sortKey="Desrivieres, Sylvane" sort="Desrivieres, Sylvane" uniqKey="Desrivieres S" first="Sylvane" last="Desrivières">Sylvane Desrivières</name><affiliation><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff></affiliation></author><author><name sortKey="Kliewer, Steven A" sort="Kliewer, Steven A" uniqKey="Kliewer S" first="Steven A." last="Kliewer">Steven A. Kliewer</name><affiliation><nlm:aff id="aff7">Department of Pharmacology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation><affiliation><nlm:aff id="aff108">Department of Molecular Biology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390</nlm:aff></affiliation></author><author><name sortKey="Mangelsdorf, David J" sort="Mangelsdorf, David J" uniqKey="Mangelsdorf D" first="David J." last="Mangelsdorf">David J. Mangelsdorf</name><affiliation><nlm:aff id="aff7">Department of Pharmacology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation><affiliation><nlm:aff id="aff8"><institution>Howard Hughes Medical Institute</institution>,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation></author><author><name sortKey="Muller, Christian P" sort="Muller, Christian P" uniqKey="Muller C" first="Christian P." last="Müller">Christian P. Müller</name><affiliation><nlm:aff id="aff22">Department of Psychiatry and Psychotherapy,<institution>Friedrich Alexander University Erlangen-Nuremberg</institution>, 91054 Erlangen,<country>Germany</country>;</nlm:aff></affiliation></author><author><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name><affiliation><nlm:aff id="aff2"><institution>The Framingham Heart Study</institution>, Framingham,<addr-line>MA</addr-line> 01702;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">The Population Sciences Branch, Division of Intramural Research,<institution>National Heart, Lung, and Blood Institute</institution>, Bethesda,<addr-line>MD</addr-line> 20824;</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation><affiliation><nlm:aff id="aff6">Medical Research Council-Public Health England Centre for Environment and Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>Alcohol is a widely consumed drug in western societies that can lead to addiction. A small shift in consumption can have dramatic consequences on public health. We performed the largest genome-wide association metaanalysis and replication study to date (>105,000 individuals) and identified a genetic basis for alcohol consumption during nonaddictive drinking. We found that a locus in the gene encoding β-Klotho is associated with alcohol consumption. β-Klotho is an essential receptor component for the endocrine FGFs, FGF19 and FGF21. Using mouse models and pharmacologic administration of FGF21, we show that β-Klotho in the brain controls alcohol drinking. These findings reveal a mechanism regulating alcohol consumption in humans that may be pharmacologically tractable for reducing alcohol intake.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Proc Natl Acad Sci U S A</journal-id><journal-id journal-id-type="iso-abbrev">Proc. Natl. Acad. Sci. U.S.A</journal-id><journal-id journal-id-type="hwp">pnas</journal-id><journal-id journal-id-type="pmc">pnas</journal-id><journal-id journal-id-type="publisher-id">PNAS</journal-id><journal-title-group><journal-title>Proceedings of the National Academy of Sciences of the United States of America</journal-title></journal-title-group><issn pub-type="ppub">0027-8424</issn><issn pub-type="epub">1091-6490</issn><publisher><publisher-name>National Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27911795</article-id><article-id pub-id-type="pmc">5167198</article-id><article-id pub-id-type="publisher-id">201611243</article-id><article-id pub-id-type="doi">10.1073/pnas.1611243113</article-id><article-categories><subj-group subj-group-type="heading"><subject>Biological Sciences</subject><subj-group><subject>Genetics</subject></subj-group></subj-group></article-categories><title-group><article-title><italic>KLB</italic> is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference</article-title><alt-title alt-title-type="short">β-Klotho, FGF21, and alcohol drinking</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Schumann</surname><given-names>Gunter</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Chunyu</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref ref-type="aff" rid="aff3"><sup>c</sup></xref><xref ref-type="aff" rid="aff4"><sup>d</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>O’Reilly</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>He</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref><xref ref-type="aff" rid="aff6"><sup>f</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Song</surname><given-names>Parkyong</given-names></name><xref ref-type="aff" rid="aff7"><sup>g</sup></xref><xref ref-type="aff" rid="aff8"><sup>h</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Bing</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ruggeri</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib 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contrib-type="author"><name><surname>Evangelou</surname><given-names>Evangelos</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref><xref ref-type="aff" rid="aff99"><sup>uuuu</sup></xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Yun</given-names></name><xref ref-type="aff" rid="aff105"><sup>aaaaa</sup></xref><xref ref-type="aff" rid="aff106"><sup>bbbbb</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rice</surname><given-names>Kenneth M.</given-names></name><xref ref-type="aff" rid="aff107"><sup>ccccc</sup></xref></contrib><contrib contrib-type="author"><name><surname>Desrivières</surname><given-names>Sylvane</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kliewer</surname><given-names>Steven A.</given-names></name><xref ref-type="aff" rid="aff7"><sup>g</sup></xref><xref ref-type="aff" rid="aff108"><sup>ddddd</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-4355-0796</contrib-id><name><surname>Mangelsdorf</surname><given-names>David J.</given-names></name><xref ref-type="aff" rid="aff7"><sup>g</sup></xref><xref ref-type="aff" rid="aff8"><sup>h</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Müller</surname><given-names>Christian P.</given-names></name><xref ref-type="aff" rid="aff22"><sup>v</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Levy</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref ref-type="aff" rid="aff3"><sup>c</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Elliott</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref><xref ref-type="aff" rid="aff6"><sup>f</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>2</sup></xref></contrib><aff id="aff1"><sup>a</sup>Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</aff><aff id="aff2"><sup>b</sup><institution>The Framingham Heart Study</institution>, Framingham,<addr-line>MA</addr-line> 01702;</aff><aff id="aff3"><sup>c</sup>The Population Sciences Branch, Division of Intramural Research,<institution>National Heart, Lung, and Blood Institute</institution>, Bethesda,<addr-line>MD</addr-line> 20824;</aff><aff id="aff4"><sup>d</sup><institution>Department of Biostatistics, Boston University School of Public Health</institution>, Boston,<addr-line>MA</addr-line> 02118;</aff><aff id="aff5"><sup>e</sup>Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</aff><aff id="aff6"><sup>f</sup>Medical Research Council-Public Health England Centre for Environment and Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</aff><aff id="aff7"><sup>g</sup>Department of Pharmacology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</aff><aff id="aff8"><sup>h</sup><institution>Howard Hughes Medical Institute</institution>,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</aff><aff id="aff9"><sup>i</sup>Genetic Epidemiology Unit, Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</aff><aff id="aff10"><sup>j</sup><institution>Section of Bioinformatics, Bayer Pharma AG</institution>, 13342 Berlin,<country>Germany</country>;</aff><aff id="aff11"><sup>k</sup>Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases,<institution>Osaka University</institution>, Osaka 565-0871,<country>Japan</country>;</aff><aff id="aff12"><sup>l</sup>Division of Genetics and Cell Biology,<institution>San Raffaele Research Institute</institution>, 20132 Milan,<country>Italy</country>;</aff><aff id="aff13"><sup>m</sup>Institute for Community Medicine,<institution>University Medicine Greifswald</institution>, Greifswald 17475,<country>Germany</country>;</aff><aff id="aff14"><sup>n</sup>Department of Epidemiology and Preventive Medicine,<institution>University of Regensburg</institution>, 93053 Regensburg,<country>Germany</country>;</aff><aff id="aff15"><sup>o</sup>CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes,<institution>Lille 2 University</institution>, 59000 Lille,<country>France</country>;</aff><aff id="aff16"><sup>p</sup>Divison of Psychiatry,<institution>University of Edinburgh</institution>, Edinburgh EH10 5HF,<country>United Kingdom</country>;</aff><aff id="aff17"><sup>q</sup>Science for Life Laboratory, Department of Immunology, Genetics and Pathology,<institution>Uppsala University</institution>, 75108 Uppsala,<country>Sweden</country>;</aff><aff id="aff18"><sup>r</sup>Estonian Genome Center,<institution>University of Tartu</institution>, 51010 Tartu,<country>Estonia</country>;</aff><aff id="aff19"><sup>s</sup>Institute for Molecular Medicine,<institution>University of Helsinki</institution>, 00290 Helsinki,<country>Finland</country>;</aff><aff id="aff20"><sup>t</sup>Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</aff><aff id="aff21"><sup>u</sup>Centre for Genomic and Experimental Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</aff><aff id="aff22"><sup>v</sup>Department of Psychiatry and Psychotherapy,<institution>Friedrich Alexander University Erlangen-Nuremberg</institution>, 91054 Erlangen,<country>Germany</country>;</aff><aff id="aff23"><sup>w</sup>Clinical Division of Neurogeriatrics, Department of Neurology,<institution>Medical University Graz</institution>, 8036 Graz,<country>Austria</country>;</aff><aff id="aff24"><sup>x</sup>Institute of Medical Informatics, Statistics and Documentation,<institution>Medical University Graz</institution>, 8036 Graz,<country>Austria</country>;</aff><aff id="aff25"><sup>y</sup>Department of Biological Psychology,<institution>Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research</institution>, 1081 BT Amsterdam,<country>The Netherlands</country>;</aff><aff id="aff26"><sup>z</sup>Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH8 9AG,<country>United Kingdom</country>;</aff><aff id="aff27"><sup>aa</sup><institution>National Institute for Health and Welfare</institution>, 00271 Helsinki,<country>Finland</country>;</aff><aff id="aff28"><sup>bb</sup><institution>Quantified Employee-Unit, Finnish Institute of Occupational Health</institution>, 00250 Helsinki,<country>Finland</country>;</aff><aff id="aff29"><sup>cc</sup>Cardiovascular Health Research Unit, Department of Medicine,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98101;</aff><aff id="aff30"><sup>dd</sup>Department of Public Health,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</aff><aff id="aff31"><sup>ee</sup>Medical Research Council Epidemiology Unit, Institute of Metabolic Science,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</aff><aff id="aff32"><sup>ff</sup>Department of Clinical Chemistry,<institution>Fimlab Laboratories and University of Tampere School of Medicine</institution>, Tampere 33520,<country>Finland</country>;</aff><aff id="aff33"><sup>gg</sup>Department of Twin Research and Genetic Epidemiology,<institution>King’s College</institution>, London SE1 7EH,<country>United Kingdom</country>;</aff><aff id="aff34"><sup>hh</sup><institution>National Institute for Health Research Biomedical Research Centre at Guy’s and St. Thomas’ Foundation Trust</institution>, London SE1 9RT, United Kingdom;</aff><aff id="aff35"><sup>ii</sup>Center for Public Health Genomics, Department of Public Health Sciences,<institution>University of Virginia</institution>, Charlottesville,<addr-line>VA</addr-line> 22903;</aff><aff id="aff36"><sup>jj</sup>Biostatistics Section, Department of Public Health Sciences,<institution>University of Virginia</institution>, Charlottesville,<addr-line>VA</addr-line> 22903;</aff><aff id="aff37"><sup>kk</sup>Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam,<institution>Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest</institution>, 1081 HL Amsterdam,<country>The Netherlands</country>;</aff><aff id="aff38"><sup>ll</sup>Institute of Health Informatics,<institution>University College London</institution>, London NW1 2DA,<country>United Kingdom</country>;</aff><aff id="aff39"><sup>mm</sup><institution>Farr Institute of Health Informatics Research</institution>, University College London Institute of Health Informatics, London NW1 2DA,<country>United Kingdom</country>;</aff><aff id="aff40"><sup>nn</sup>Department of Medicine,<institution>Beth Israel Deaconess Medical Center and Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02215;</aff><aff id="aff41"><sup>oo</sup>Department of Cardiovascular Sciences, University of Leicester,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</aff><aff id="aff42"><sup>pp</sup>National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</aff><aff id="aff43"><sup>qq</sup>Division of Epidemiology, Human Genetics, and Environmental Sciences,<institution>University of Texas Health Sciences Center</institution>, Houston,<addr-line>TX</addr-line> 77225;</aff><aff id="aff44"><sup>rr</sup>Faculty of Medicine,<institution>University of Tartu</institution>, 50411 Tartu,<country>Estonia</country>;</aff><aff id="aff45"><sup>ss</sup>Department of Molecular Epidemiology, Institute of Epidemiology II,<institution>Helmholtz Zentrum München</institution>, 85764 Neuherberg,<country>Germany</country>;</aff><aff id="aff46"><sup>tt</sup><institution>Institute for Maternal and Child Health—Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo</institution>, 34137 Trieste,<country>Italy</country>;</aff><aff id="aff47"><sup>uu</sup>Division of Preventive Medicine,<institution>Brigham and Women’s Hospital</institution>, Boston,<addr-line>MA</addr-line> 02215;</aff><aff id="aff48"><sup>vv</sup>Medical Research Council Epidemiology Unit,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</aff><aff id="aff49"><sup>ww</sup><institution>Research Institute, Icelandic Heart Association</institution>, 201 Kopavogur,<country>Iceland</country>;</aff><aff id="aff50"><sup>xx</sup>Alzheimer Scotland Research Centre,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</aff><aff id="aff51"><sup>yy</sup>Interfaculty Institute for Genetics and Functional Genomics,<institution>University Medicine Greifswald</institution>, 17475 Greifswald,<country>Germany</country>;</aff><aff id="aff52"><sup>zz</sup>Department of Cardiology,<institution>Leiden University Medical Center</institution>, 2300 RC Leiden,<country>The Netherlands</country>;</aff><aff id="aff53"><sup>aaa</sup>Department of Gerontology and Geriatrics,<institution>Leiden University Medical Center</institution>, 2300 RC Leiden,<country>The Netherlands</country>;</aff><aff id="aff54"><sup>bbb</sup>Department of internal Medicine,<institution>Erasmus Medical Center</institution>, 3015 CN Rotterdam,<country>The Netherlands</country>;</aff><aff id="aff55"><sup>ccc</sup>Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</aff><aff id="aff56"><sup>ddd</sup>Department of Cardiology, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</aff><aff id="aff57"><sup>eee</sup>Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh,<institution>Western General Hospital</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</aff><aff id="aff58"><sup>fff</sup>Department of Medical Sciences,<institution>University of Trieste</institution>, 34149 Trieste,<country>Italy</country>;</aff><aff id="aff59"><sup>ggg</sup>Human Genetics Center,<institution>University of Texas Health Science Center at Houston</institution>, Houston,<addr-line>TX</addr-line> 77225;</aff><aff id="aff60"><sup>hhh</sup>Division of Epidemiology,<institution>University of Texas Health Science Center at Houston</institution>, Houston,<addr-line>TX</addr-line> 77225;</aff><aff id="aff61"><sup>iii</sup>Department of Cardiology,<institution>Ealing Hospital</institution>, Middlesex UB1 3HW,<country>United Kingdom</country>;</aff><aff id="aff62"><sup>jjj</sup><institution>Imperial College Healthcare National Health Service Trust</institution>, London W12 0HS,<country>United Kingdom</country>;</aff><aff id="aff63"><sup>kkk</sup><institution>Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02115;</aff><aff id="aff64"><sup>lll</sup>Psychology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</aff><aff id="aff65"><sup>mmm</sup>Department of General Practice and Primary Health Care,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</aff><aff id="aff66"><sup>nnn</sup>Unit of General Practice,<institution>Helsinki University Central Hospital</institution>, 00014 Helsinki,<country>Finland</country>;</aff><aff id="aff67"><sup>ooo</sup><institution>Folkhälsan Research Centre</institution>, Public Health Research, 00290 Helsinki,<country>Finland</country>;</aff><aff id="aff68"><sup>ppp</sup><institution>Vasa Central Hospital</institution>, 65130 Vasa,<country>Finland</country>;</aff><aff id="aff69"><sup>qqq</sup>Institute for Biochemistry and Molecular Medicine,<institution>Friedrich Alexander University Erlangen-Nuremberg</institution>, 91054 Erlangen,<country>Germany</country>;</aff><aff id="aff70"><sup>rrr</sup>Department of Genomics of Common Disease, School of Public Health,<institution>Imperial College London</institution>, London W12 0HR,<country>United Kingdom</country>;</aff><aff id="aff71"><sup>sss</sup>Department of Psychiatry and Psychotherapy,<institution>University Medicine Greifswald</institution>, 17475 Greifswald,<country>Germany</country>;</aff><aff id="aff72"><sup>ttt</sup>Faculty of Medicine,<institution>University of Iceland</institution>, 101 Reykjavik,<country>Iceland</country>;</aff><aff id="aff73"><sup>uuu</sup>National Institute on Aging,<institution>NIH</institution>, Bethesda,<addr-line>MD</addr-line> 20892;</aff><aff id="aff74"><sup>vvv</sup>Department of Obstetrics and Gynecology,<institution>Oulu University Hospital</institution>, 90029 Oulu,<country>Finland</country>;</aff><aff id="aff75"><sup>www</sup>Medical Research Center,<institution>University of Oulu</institution>, 90014 Oulu,<country>Finland</country>;</aff><aff id="aff76"><sup>xxx</sup>Unit of Primary Care,<institution>Oulu University Hospital</institution>, 90220 Oulu,<country>Finland</country>;</aff><aff id="aff77"><sup>yyy</sup>Department of Psychiatry,<institution>Washington University School of Medicine in St. Louis</institution>, St. Louis,<addr-line>MO</addr-line> 63110;</aff><aff id="aff78"><sup>zzz</sup>Institute of Medical Sciences,<institution>University of Aberdeen</institution>, Aberdeen AB25 2ZD,<country>United Kingdom</country>;</aff><aff id="aff79"><sup>aaaa</sup>Institute of Epidemiology II, Helmholtz Zentrum München,<institution>German Research Center for Environmental Health GmbH</institution>, D-85764 Neuherberg,<country>Germany</country>;</aff><aff id="aff80"><sup>bbbb</sup>Center for Life Course Epidemiology, Faculty of Medicine,<institution>University of Oulu</institution>, Oulu FI-90014,<country>Finland</country>;</aff><aff id="aff81"><sup>cccc</sup>Biocenter Oulu,<institution>University of Oulu</institution>, Oulu FI-90014,<country>Finland</country>;</aff><aff id="aff82"><sup>dddd</sup>Faculty of Medicine, National Heart & Lung Institute, Cardiovascular Science, Hammersmith Hospital,<institution>Imperial College London</institution>, London W12 0NN,<country>United Kingdom</country>;</aff><aff id="aff83"><sup>eeee</sup>Institute of Social and Preventive Medicine,<institution>Centre Hospitalier Universitaire Vaudoise</institution>, 1010 Lausanne,<country>Switzerland</country>;</aff><aff id="aff84"><sup>ffff</sup>Collegium for Advanced Studies,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</aff><aff id="aff85"><sup>gggg</sup>Institute of Behavioural Sciences,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</aff><aff id="aff86"><sup>hhhh</sup>Wake Forest School of Medicine, Department of Epidemiology & Prevention, Public Health Sciences,<institution>Wake Forest School of Medicine</institution>, Winston-Salem,<addr-line>NC</addr-line> 27157;</aff><aff id="aff87"><sup>iiii</sup><institution>Department of Psychiatry, Washington University School of Medicine</institution>, St. Louis,<addr-line>MO</addr-line> 63110;</aff><aff id="aff88"><sup>jjjj</sup>Genetic Epidemiology,<institution>Queensland Institute of Medical Research Berghofer Medical Research Institute</institution>, Herston, Brisbane QLD 4029,<country>Australia</country>;</aff><aff id="aff89"><sup>kkkk</sup>Department of Epidemiology,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98195;</aff><aff id="aff90"><sup>llll</sup>Department of Health Services,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98195;</aff><aff id="aff91"><sup>mmmm</sup>Group Health Cooperative,<institution>Group Health Research Institute</institution>, Seattle,<addr-line>WA</addr-line> 98101;</aff><aff id="aff92"><sup>nnnn</sup>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital,<institution>University of Turku</institution>, Turku 20520,<country>Finland</country>;</aff><aff id="aff93"><sup>oooo</sup>Research Centre of Applied and Preventive Cardiovascular Medicine,<institution>University of Turku</institution>, Turku 20520,<country>Finland</country>;</aff><aff id="aff94"><sup>pppp</sup>Department of Psychological and Brain Sciences,<institution>Indiana University</institution>, Bloomington,<addr-line>IN</addr-line> 47405;</aff><aff id="aff95"><sup>qqqq</sup>Institute for Translational Genomics and Population Sciences,<institution>Los Angeles Biomedical Research Institute at Harbor–University of California, Los Angeles Medical Center</institution>, Torrance,<addr-line>CA</addr-line> 90509;</aff><aff id="aff96"><sup>rrrr</sup>Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine,<institution>Medical University of Graz</institution>, 8010 Graz,<country>Austria</country>;</aff><aff id="aff97"><sup>ssss</sup>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine,<institution>University of Glasgow</institution>, Glasgow G31 2ER,<country>United Kingdom</country>;</aff><aff id="aff98"><sup>tttt</sup>Population Health Research Institute, St. George's,<institution>University of London</institution>, London SW17 0RE,<country>United Kingdom</country>;</aff><aff id="aff99"><sup>uuuu</sup>Department of Hygiene and Epidemiology,<institution>University of Ioannina Medical School</institution>, 45110 Ioannina,<country>Greece</country>;</aff><aff id="aff100"><sup>vvvv</sup>Department of Genetics, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</aff><aff id="aff101"><sup>wwww</sup>Durrer Center for Cardiogenetic Research,<institution>Interuniversity Cardiology Institute of The Netherlands–Netherlands Heart Institute</institution>, 3511GC Utrecht,<country>The Netherlands</country>;</aff><aff id="aff102"><sup>xxxx</sup>Department of Medicine, Internal Medicine,<institution>Lausanne University Hospital</institution>, 1011 Lausanne,<country>Switzerland</country>;</aff><aff id="aff103"><sup>yyyy</sup>Department of Endocrinology, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</aff><aff id="aff104"><sup>zzzz</sup>Division of Biological Research on Drug Dependence, Department of Pharmaceutical, Biosciences,<institution>Uppsala University</institution>, 751 24 Uppsala,<country>Sweden</country>;</aff><aff id="aff105"><sup>aaaaa</sup>Key Laboratory of Metabolism and Molecular Medicine,<institution>Ministry of Education</institution>, 200032 Shanghai,<country>People’s Republic of China</country>;</aff><aff id="aff106"><sup>bbbbb</sup>Department of Biochemistry and Molecular Biology,<institution>Fudan University Shanghai Medical College</institution>, 200032 Shanghai,<country>People’s Republic of China</country>;</aff><aff id="aff107"><sup>ccccc</sup>Department of Biostatistics,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98195;</aff><aff id="aff108"><sup>ddddd</sup>Department of Molecular Biology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390</aff></contrib-group><author-notes><corresp id="cor1"><sup>2</sup>To whom correspondence may be addressed. Email: <email>gunter.schumann@kcl.ac.uk</email>, <email>davo.mango@utsouthwestern.edu</email>, or <email>p.elliott@imperial.ac.uk</email>.</corresp><fn fn-type="edited-by"><p>Contributed by David J. Mangelsdorf, October 18, 2016 (sent for review July 11, 2016; reviewed by Robert Adron Harris and Victor Hesselbrock)</p></fn><fn fn-type="con"><p>Author contributions: G.S., C. Liu, P.S., J. Laitinen, T.S., R. Schmidt, J.M.S., S.T., D.I.B., J.C., D.I.C., T.D., E.d.G., I.D., J.G.E., T.E., O.H.F., P.F., C.G., H.J.G., V.G., U.G., T.B.H., A.-L.H., A.C.H., A.H., C.H., M.-R.J., J.W.J., J.K., J.S.K., T.L., Yongmei Liu, P.A.F.M., N.M., A. Morrison, B. Penninx, N.P., B. Psaty, O.R., P.R., R. Rose, J.I.R., N.J.S., H.S., T.D.S., D. Stott, D. Strachan, I.T., P.v.d.H., C.M.v.D., P.M.-V., N.J.W., J. Wilson, B.W., S.A.K., D.J.M., C.P.M., D.L., and P.E. designed research; P.S. and G.B. performed research; G.S., C. Liu, P.O., H.G., P.S., B.X., B.R., N.A., T.J., S.P., M.S.L., S.A., C.B., S.B., S.C., T.-K.C., S.E., K.F., J.H., S.E.H., S.H., E.H., J.-J.H., A.J., P.K.J., N.K., J. Laitinen, R.L., A.L., J. Luan, L.-P.L., M.M., A. Manichaikul, H.M., Y.M., A. Moayyeri, K.M., C.N., J.N., E.P., R. Rawal, A.R., L.R., C.S., T.S., K.S., R. Scott, A.V.S., J.M.S., A.T., S.T., A.G.U., C.V., A.-C.V., N.V., V.V., D.V., J. Wedenoja, L.Y., B.Y., W.Z., J.H.Z., V.E., C.G., A.C.H., L.H., Z.K., J. Lahti, C. Langenberg, Yongmei Liu, N.M., N.P., D. Strachan, P.V., J.B.W., G.B., E.E., Yun Liu, K.M.R., S.D., S.A.K., D.J.M., C.P.M., D.L., and P.E. analyzed data; C. Liu, S.E.H., N.K., J. Luan, K.M., J.N., C.S., R. Schmidt, J.M.S., A.G.U., C.V., V.V., D.I.B., J.C., D.I.C., E.d.G., I.D., T.E., O.H.F., P.F., V.G., U.G., T.B.H., A.-L.H., A.C.H., L.H., A.H., C.H., M.-R.J., J.W.J., J.K., J.S.K., T.L., Yongmei Liu, P.A.F.M., N.M., A. Morrison, B. Penninx, B. Psaty, O.R., P.R., R. Rose, J.I.R., N.J.S., H.S., D. Stott, D. Strachan, I.T., P.v.d.H., C.M.v.D., P.M.-V., N.J.W., J. Wilson, B.W., G.B., and Yun Liu contributed to data acquisition; and G.S., C. Liu, P.O., H.G., P.S., B.X., B.R., E.E., S.D., S.A.K., D.J.M., C.P.M., D.L., and P.E. wrote the paper.</p></fn><fn fn-type="con"><p>Reviewers: R.A.H., The University of Texas at Austin; and V.H., University of Connecticut Health Center.</p></fn><fn fn-type="equal" id="fn1"><p><sup>1</sup>G.S., C. Liu, P.O., H.G., P.S., S.D., S.A.K., D.J.M., C.P.M., D.L., and P.E. contributed equally to this work.</p></fn></author-notes><pub-date pub-type="ppub"><day>13</day><month>12</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>28</day><month>11</month><year>2016</year></pub-date><volume>113</volume><issue>50</issue><fpage>14372</fpage><lpage>14377</lpage><self-uri xlink:title="pdf" xlink:href="pnas.201611243.pdf"></self-uri><abstract abstract-type="executive-summary"><title>Significance</title><p>Alcohol is a widely consumed drug in western societies that can lead to addiction. A small shift in consumption can have dramatic consequences on public health. We performed the largest genome-wide association metaanalysis and replication study to date (>105,000 individuals) and identified a genetic basis for alcohol consumption during nonaddictive drinking. We found that a locus in the gene encoding β-Klotho is associated with alcohol consumption. β-Klotho is an essential receptor component for the endocrine FGFs, FGF19 and FGF21. Using mouse models and pharmacologic administration of FGF21, we show that β-Klotho in the brain controls alcohol drinking. These findings reveal a mechanism regulating alcohol consumption in humans that may be pharmacologically tractable for reducing alcohol intake.</p></abstract><abstract><p>Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (<italic>KLB</italic>) as a locus associated with alcohol consumption (rs11940694; <italic>P</italic> = 9.2 × 10<sup>−12</sup>). β-Klotho is an obligate coreceptor for the hormone FGF21, which is secreted from the liver and implicated in macronutrient preference in humans. We show that brain-specific β-Klotho KO mice have an increased alcohol preference and that FGF21 inhibits alcohol drinking by acting on the brain. These data suggest that a liver–brain endocrine axis may play an important role in the regulation of alcohol drinking behavior and provide a unique pharmacologic target for reducing alcohol consumption.</p></abstract><kwd-group><kwd>alcohol consumption</kwd><kwd>human</kwd><kwd>β-Klotho</kwd><kwd>FGF21</kwd><kwd>mouse model</kwd></kwd-group><counts><page-count count="6"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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