Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Specific function of phosphoinositide 3-kinase beta in the control of DNA replication</title><author><name sortKey="Marques, Miriam" sort="Marques, Miriam" uniqKey="Marques M" first="Miriam" last="Marqués">Miriam Marqués</name><affiliation><nlm:aff id="aff1">Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, Madrid E-28049, Spain;</nlm:aff></affiliation></author><author><name sortKey="Kumar, Amit" sort="Kumar, Amit" uniqKey="Kumar A" first="Amit" last="Kumar">Amit Kumar</name><affiliation><nlm:aff id="aff1">Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, Madrid E-28049, Spain;</nlm:aff></affiliation></author><author><name sortKey="Poveda, Ana M" sort="Poveda, Ana M" uniqKey="Poveda A" first="Ana M." last="Poveda">Ana M. Poveda</name><affiliation><nlm:aff wicri:cut="; and" id="aff2">Institute of Human Genetics, Centre National de la Recherche Scientifique Unité Propre de Recherche 1142, 141 Rue de la Cardonille, F-34396 Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Zuluaga, Susana" sort="Zuluaga, Susana" uniqKey="Zuluaga S" first="Susana" last="Zuluaga">Susana Zuluaga</name><affiliation><nlm:aff id="aff1">Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, Madrid E-28049, Spain;</nlm:aff></affiliation></author><author><name sortKey="Hernandez, Carmen" sort="Hernandez, Carmen" uniqKey="Hernandez C" first="Carmen" last="Hernández">Carmen Hernández</name><affiliation><nlm:aff id="aff1">Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, Madrid E-28049, Spain;</nlm:aff></affiliation></author><author><name sortKey="Jackson, Shaun" sort="Jackson, Shaun" uniqKey="Jackson S" first="Shaun" last="Jackson">Shaun Jackson</name><affiliation><nlm:aff id="aff3">Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia</nlm:aff></affiliation></author><author><name sortKey="Pasero, Philippe" sort="Pasero, Philippe" uniqKey="Pasero P" first="Philippe" last="Pasero">Philippe Pasero</name><affiliation><nlm:aff wicri:cut="; and" id="aff2">Institute of Human Genetics, Centre National de la Recherche Scientifique Unité Propre de Recherche 1142, 141 Rue de la Cardonille, F-34396 Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Carrera, Ana C" sort="Carrera, Ana C" uniqKey="Carrera A" first="Ana C." last="Carrera">Ana C. Carrera</name><affiliation><nlm:aff id="aff1">Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, Madrid E-28049, Spain;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19416922</idno><idno type="pmc">2678616</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678616</idno><idno type="RBID">PMC:2678616</idno><idno type="doi">10.1073/pnas.0812000106</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">001B28</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001B28</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Specific function of phosphoinositide 3-kinase beta in the control of DNA replication</title><author><name sortKey="Marques, Miriam" sort="Marques, Miriam" uniqKey="Marques M" first="Miriam" last="Marqués">Miriam Marqués</name><affiliation><nlm:aff id="aff1">Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, Madrid E-28049, Spain;</nlm:aff></affiliation></author><author><name sortKey="Kumar, Amit" sort="Kumar, Amit" uniqKey="Kumar A" first="Amit" last="Kumar">Amit Kumar</name><affiliation><nlm:aff id="aff1">Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, Madrid E-28049, Spain;</nlm:aff></affiliation></author><author><name sortKey="Poveda, Ana M" sort="Poveda, Ana M" uniqKey="Poveda A" first="Ana M." last="Poveda">Ana M. Poveda</name><affiliation><nlm:aff wicri:cut="; and" id="aff2">Institute of Human Genetics, Centre National de la Recherche Scientifique Unité Propre de Recherche 1142, 141 Rue de la Cardonille, F-34396 Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Zuluaga, Susana" sort="Zuluaga, Susana" uniqKey="Zuluaga S" first="Susana" last="Zuluaga">Susana Zuluaga</name><affiliation><nlm:aff id="aff1">Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, Madrid E-28049, Spain;</nlm:aff></affiliation></author><author><name sortKey="Hernandez, Carmen" sort="Hernandez, Carmen" uniqKey="Hernandez C" first="Carmen" last="Hernández">Carmen Hernández</name><affiliation><nlm:aff id="aff1">Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, Madrid E-28049, Spain;</nlm:aff></affiliation></author><author><name sortKey="Jackson, Shaun" sort="Jackson, Shaun" uniqKey="Jackson S" first="Shaun" last="Jackson">Shaun Jackson</name><affiliation><nlm:aff id="aff3">Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia</nlm:aff></affiliation></author><author><name sortKey="Pasero, Philippe" sort="Pasero, Philippe" uniqKey="Pasero P" first="Philippe" last="Pasero">Philippe Pasero</name><affiliation><nlm:aff wicri:cut="; and" id="aff2">Institute of Human Genetics, Centre National de la Recherche Scientifique Unité Propre de Recherche 1142, 141 Rue de la Cardonille, F-34396 Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Carrera, Ana C" sort="Carrera, Ana C" uniqKey="Carrera A" first="Ana C." last="Carrera">Ana C. Carrera</name><affiliation><nlm:aff id="aff1">Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, Madrid E-28049, Spain;</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Class I<sub>A</sub> phosphoinositide 3-kinase (PI3K) are enzymes comprised of a p85 regulatory and a p110 catalytic subunit that induce formation of 3-polyphosphoinositides, which activate numerous downstream targets. PI3K controls cell division. Of the 2 ubiquitous PI3K isoforms, α has selective action in cell growth and cell cycle entry, but no specific function in cell division has been described for β. We report here a unique function for PI3Kβ in the control of DNA replication. PI3Kβ regulated DNA replication through kinase-dependent and kinase-independent mechanisms. PI3Kβ was found in the nucleus, where it associated PKB. Modulation of PI3Kβ activity altered the DNA replication rate by controlling proliferating cell nuclear antigen (PCNA) binding to chromatin and to DNA polymerase δ. PI3Kβ exerted this action by regulating the nuclear activation of PKB in S phase, and in turn phosphorylation of PCNA negative regulator p21<sup>Cip</sup>. Also, p110β associated with PCNA and controlled PCNA loading onto chromatin in a kinase-independent manner. These results show a selective function of PI3Kβ in the control of DNA replication.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Proc Natl Acad Sci U S A</journal-id><journal-id journal-id-type="hwp">pnas</journal-id><journal-id journal-id-type="pmc">pnas</journal-id><journal-id journal-id-type="publisher-id">PNAS</journal-id><journal-title-group><journal-title>Proceedings of the National Academy of Sciences of the United States of America</journal-title></journal-title-group><issn pub-type="ppub">0027-8424</issn><issn pub-type="epub">1091-6490</issn><publisher><publisher-name>National Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19416922</article-id><article-id pub-id-type="pmc">2678616</article-id><article-id pub-id-type="publisher-id">7811</article-id><article-id pub-id-type="doi">10.1073/pnas.0812000106</article-id><article-categories><subj-group subj-group-type="heading"><subject>Biological Sciences</subject><subj-group><subject>Medical Sciences</subject></subj-group></subj-group></article-categories><title-group><article-title>Specific function of phosphoinositide 3-kinase beta in the control of DNA replication</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Marqués</surname><given-names>Miriam</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="author-notes" rid="FN1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kumar</surname><given-names>Amit</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="author-notes" rid="FN1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Poveda</surname><given-names>Ana M.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zuluaga</surname><given-names>Susana</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hernández</surname><given-names>Carmen</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jackson</surname><given-names>Shaun</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pasero</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Carrera</surname><given-names>Ana C.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="corresp" rid="cor1"><sup>2</sup></xref></contrib><aff id="aff1"><sup>a</sup>Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, Madrid E-28049, Spain;</aff><aff id="aff2"><sup>b</sup>Institute of Human Genetics, Centre National de la Recherche Scientifique Unité Propre de Recherche 1142, 141 Rue de la Cardonille, F-34396 Montpellier, France; and</aff><aff id="aff3"><sup>c</sup>Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia</aff></contrib-group><author-notes><corresp id="cor1"><sup>2</sup>To whom correspondence should be addressed. E-mail: <email>acarrera@cnb.csic.es</email></corresp><fn fn-type="edited-by"><p>Edited by Inder M. Verma, The Salk Institute for Biological Studies, La Jolla, CA, and approved March 20, 2009</p></fn><fn fn-type="con"><p>Author contributions: A.C.C. designed research; M.M., A.K., A.M.P., S.Z., and C.H. performed research; S.J. contributed new reagents/analytic tools; M.M., A.K., P.P., and A.C.C. analyzed data; and A.C.C. wrote the paper.</p></fn><fn id="FN1" fn-type="equal"><p><sup>1</sup>M.M. and A.K. contributed equally to this work.</p></fn></author-notes><pub-date pub-type="ppub"><day>5</day><month>5</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>22</day><month>4</month><year>2009</year></pub-date><volume>106</volume><issue>18</issue><fpage>7525</fpage><lpage>7530</lpage><history><date date-type="received"><day>25</day><month>11</month><year>2008</year></date></history><permissions></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zpq01809007525.pdf"></self-uri><abstract><p>Class I<sub>A</sub> phosphoinositide 3-kinase (PI3K) are enzymes comprised of a p85 regulatory and a p110 catalytic subunit that induce formation of 3-polyphosphoinositides, which activate numerous downstream targets. PI3K controls cell division. Of the 2 ubiquitous PI3K isoforms, α has selective action in cell growth and cell cycle entry, but no specific function in cell division has been described for β. We report here a unique function for PI3Kβ in the control of DNA replication. PI3Kβ regulated DNA replication through kinase-dependent and kinase-independent mechanisms. PI3Kβ was found in the nucleus, where it associated PKB. Modulation of PI3Kβ activity altered the DNA replication rate by controlling proliferating cell nuclear antigen (PCNA) binding to chromatin and to DNA polymerase δ. PI3Kβ exerted this action by regulating the nuclear activation of PKB in S phase, and in turn phosphorylation of PCNA negative regulator p21<sup>Cip</sup>. Also, p110β associated with PCNA and controlled PCNA loading onto chromatin in a kinase-independent manner. These results show a selective function of PI3Kβ in the control of DNA replication.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B28 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001B28 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |