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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Altered retinoic acid signalling underpins dentition evolution</title><author><name sortKey="Gibert, Yann" sort="Gibert, Yann" uniqKey="Gibert Y" first="Yann" last="Gibert">Yann Gibert</name><affiliation><nlm:aff id="af2"><addr-line>Metabolic Genetic Diseases Laboratory, Metabolic Research Unit</addr-line>,<institution>School of Medicine, Deakin University</institution>,<addr-line>75 Pigdons Road, Waurn Ponds, Victoria 3217</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Samarut, Eric" sort="Samarut, Eric" uniqKey="Samarut E" first="Eric" last="Samarut">Eric Samarut</name><affiliation><nlm:aff id="af1"><addr-line>Institut de Génomique Fonctionnelle de Lyon</addr-line>;<institution>UMR 5242 du CNRS; Université de Lyon; Université</institution><institution>Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon</institution>,<addr-line>46 Allée d'Italie, 69364 Lyon Cedex 07</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Pasco Viel, Emmanuel" sort="Pasco Viel, Emmanuel" uniqKey="Pasco Viel E" first="Emmanuel" last="Pasco-Viel">Emmanuel Pasco-Viel</name><affiliation><nlm:aff id="af1"><addr-line>Institut de Génomique Fonctionnelle de Lyon</addr-line>;<institution>UMR 5242 du CNRS; Université de Lyon; Université</institution><institution>Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon</institution>,<addr-line>46 Allée d'Italie, 69364 Lyon Cedex 07</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Bernard, Laure" sort="Bernard, Laure" uniqKey="Bernard L" first="Laure" last="Bernard">Laure Bernard</name><affiliation><nlm:aff id="af1"><addr-line>Institut de Génomique Fonctionnelle de Lyon</addr-line>;<institution>UMR 5242 du CNRS; Université de Lyon; Université</institution><institution>Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon</institution>,<addr-line>46 Allée d'Italie, 69364 Lyon Cedex 07</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Borday Birraux, Veronique" sort="Borday Birraux, Veronique" uniqKey="Borday Birraux V" first="Véronique" last="Borday-Birraux">Véronique Borday-Birraux</name><affiliation><nlm:aff id="af3"><addr-line>Laboratoire EGCE UMR CNRS 9191, IRD247, Université Paris Sud</addr-line>,<institution>Université Paris Diderot Sorbonne Paris Cité</institution>,<addr-line>91198 Gif-sur-Yvette</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Sadier, Alexa" sort="Sadier, Alexa" uniqKey="Sadier A" first="Alexa" last="Sadier">Alexa Sadier</name><affiliation><nlm:aff id="af1"><addr-line>Institut de Génomique Fonctionnelle de Lyon</addr-line>;<institution>UMR 5242 du CNRS; Université de Lyon; Université</institution><institution>Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon</institution>,<addr-line>46 Allée d'Italie, 69364 Lyon Cedex 07</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Labbe, Catherine" sort="Labbe, Catherine" uniqKey="Labbe C" first="Catherine" last="Labbé">Catherine Labbé</name><affiliation><nlm:aff id="af4"><institution>INRA UR 1037 SCRIBE</institution>,<addr-line>IFR 140, 35042 Rennes Cedex</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Viriot, Laurent" sort="Viriot, Laurent" uniqKey="Viriot L" first="Laurent" last="Viriot">Laurent Viriot</name><affiliation><nlm:aff id="af1"><addr-line>Institut de Génomique Fonctionnelle de Lyon</addr-line>;<institution>UMR 5242 du CNRS; Université de Lyon; Université</institution><institution>Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon</institution>,<addr-line>46 Allée d'Italie, 69364 Lyon Cedex 07</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Laudet, Vincent" sort="Laudet, Vincent" uniqKey="Laudet V" first="Vincent" last="Laudet">Vincent Laudet</name><affiliation><nlm:aff id="af1"><addr-line>Institut de Génomique Fonctionnelle de Lyon</addr-line>;<institution>UMR 5242 du CNRS; Université de Lyon; Université</institution><institution>Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon</institution>,<addr-line>46 Allée d'Italie, 69364 Lyon Cedex 07</addr-line>,<country>France</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25652838</idno><idno type="pmc">4344156</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344156</idno><idno type="RBID">PMC:4344156</idno><idno type="doi">10.1098/rspb.2014.2764</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001B00</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001B00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Altered retinoic acid signalling underpins dentition evolution</title><author><name sortKey="Gibert, Yann" sort="Gibert, Yann" uniqKey="Gibert Y" first="Yann" last="Gibert">Yann Gibert</name><affiliation><nlm:aff id="af2"><addr-line>Metabolic Genetic Diseases Laboratory, Metabolic Research Unit</addr-line>,<institution>School of Medicine, Deakin University</institution>,<addr-line>75 Pigdons Road, Waurn Ponds, Victoria 3217</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Samarut, Eric" sort="Samarut, Eric" uniqKey="Samarut E" first="Eric" last="Samarut">Eric Samarut</name><affiliation><nlm:aff id="af1"><addr-line>Institut de Génomique Fonctionnelle de Lyon</addr-line>;<institution>UMR 5242 du CNRS; Université de Lyon; Université</institution><institution>Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon</institution>,<addr-line>46 Allée d'Italie, 69364 Lyon Cedex 07</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Pasco Viel, Emmanuel" sort="Pasco Viel, Emmanuel" uniqKey="Pasco Viel E" first="Emmanuel" last="Pasco-Viel">Emmanuel Pasco-Viel</name><affiliation><nlm:aff id="af1"><addr-line>Institut de Génomique Fonctionnelle de Lyon</addr-line>;<institution>UMR 5242 du CNRS; Université de Lyon; Université</institution><institution>Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon</institution>,<addr-line>46 Allée d'Italie, 69364 Lyon Cedex 07</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Bernard, Laure" sort="Bernard, Laure" uniqKey="Bernard L" first="Laure" last="Bernard">Laure Bernard</name><affiliation><nlm:aff id="af1"><addr-line>Institut de Génomique Fonctionnelle de Lyon</addr-line>;<institution>UMR 5242 du CNRS; Université de Lyon; Université</institution><institution>Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon</institution>,<addr-line>46 Allée d'Italie, 69364 Lyon Cedex 07</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Borday Birraux, Veronique" sort="Borday Birraux, Veronique" uniqKey="Borday Birraux V" first="Véronique" last="Borday-Birraux">Véronique Borday-Birraux</name><affiliation><nlm:aff id="af3"><addr-line>Laboratoire EGCE UMR CNRS 9191, IRD247, Université Paris Sud</addr-line>,<institution>Université Paris Diderot Sorbonne Paris Cité</institution>,<addr-line>91198 Gif-sur-Yvette</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Sadier, Alexa" sort="Sadier, Alexa" uniqKey="Sadier A" first="Alexa" last="Sadier">Alexa Sadier</name><affiliation><nlm:aff id="af1"><addr-line>Institut de Génomique Fonctionnelle de Lyon</addr-line>;<institution>UMR 5242 du CNRS; Université de Lyon; Université</institution><institution>Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon</institution>,<addr-line>46 Allée d'Italie, 69364 Lyon Cedex 07</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Labbe, Catherine" sort="Labbe, Catherine" uniqKey="Labbe C" first="Catherine" last="Labbé">Catherine Labbé</name><affiliation><nlm:aff id="af4"><institution>INRA UR 1037 SCRIBE</institution>,<addr-line>IFR 140, 35042 Rennes Cedex</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Viriot, Laurent" sort="Viriot, Laurent" uniqKey="Viriot L" first="Laurent" last="Viriot">Laurent Viriot</name><affiliation><nlm:aff id="af1"><addr-line>Institut de Génomique Fonctionnelle de Lyon</addr-line>;<institution>UMR 5242 du CNRS; Université de Lyon; Université</institution><institution>Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon</institution>,<addr-line>46 Allée d'Italie, 69364 Lyon Cedex 07</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Laudet, Vincent" sort="Laudet, Vincent" uniqKey="Laudet V" first="Vincent" last="Laudet">Vincent Laudet</name><affiliation><nlm:aff id="af1"><addr-line>Institut de Génomique Fonctionnelle de Lyon</addr-line>;<institution>UMR 5242 du CNRS; Université de Lyon; Université</institution><institution>Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon</institution>,<addr-line>46 Allée d'Italie, 69364 Lyon Cedex 07</addr-line>,<country>France</country></nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the Royal Society B: Biological Sciences</title><idno type="ISSN">0962-8452</idno><idno type="eISSN">1471-2954</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Small variations in signalling pathways have been linked to phenotypic diversity and speciation. In vertebrates, teeth represent a reservoir of adaptive morphological structures that are prone to evolutionary change. Cyprinid fish display an impressive diversity in tooth number, but the signals that generate such diversity are unknown. Here, we show that retinoic acid (RA) availability influences tooth number size in Cyprinids. Heterozygous adult zebrafish heterozygous for the <italic>cyp26b1</italic> mutant that encodes an enzyme able to degrade RA possess an extra tooth in the ventral row. Expression analysis of pharyngeal mesenchyme markers such as <italic>dlx2a</italic> and <italic>lhx6</italic> shows lateral, anterior and dorsal expansion of these markers in RA-treated embryos, whereas the expression of the dental epithelium markers <italic>dlx2b</italic> and <italic>dlx3b</italic> is unchanged. Our analysis suggests that changes in RA signalling play an important role in the diversification of teeth in Cyprinids. Our work illustrates that through subtle changes in the expression of rate-limiting enzymes, the RA pathway is an active player of tooth evolution in fish.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Proc Biol Sci</journal-id><journal-id journal-id-type="iso-abbrev">Proc. Biol. Sci</journal-id><journal-id journal-id-type="publisher-id">RSPB</journal-id><journal-id journal-id-type="hwp">royprsb</journal-id><journal-title-group><journal-title>Proceedings of the Royal Society B: Biological Sciences</journal-title></journal-title-group><issn pub-type="ppub">0962-8452</issn><issn pub-type="epub">1471-2954</issn><publisher><publisher-name>The Royal Society</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25652838</article-id><article-id pub-id-type="pmc">4344156</article-id><article-id pub-id-type="doi">10.1098/rspb.2014.2764</article-id><article-id pub-id-type="publisher-id">rspb20142764</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>1001</subject><subject>70</subject><subject>58</subject><subject>129</subject></subj-group><subj-group subj-group-type="heading"><subject>Research Articles</subject></subj-group></article-categories><title-group><article-title>Altered retinoic acid signalling underpins dentition evolution</article-title><alt-title alt-title-type="short">RA signaling in cypriniforme dentition</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gibert</surname><given-names>Yann</given-names></name><xref ref-type="aff" rid="af2">2</xref><xref ref-type="author-notes" rid="AN2">†</xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Samarut</surname><given-names>Eric</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="author-notes" rid="AN2">†</xref></contrib><contrib contrib-type="author"><name><surname>Pasco-Viel</surname><given-names>Emmanuel</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bernard</surname><given-names>Laure</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Borday-Birraux</surname><given-names>Véronique</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Sadier</surname><given-names>Alexa</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Labbé</surname><given-names>Catherine</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Viriot</surname><given-names>Laurent</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Laudet</surname><given-names>Vincent</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>Institut de Génomique Fonctionnelle de Lyon</addr-line>;<institution>UMR 5242 du CNRS; Université de Lyon; Université</institution><institution>Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon</institution>,<addr-line>46 Allée d'Italie, 69364 Lyon Cedex 07</addr-line>,<country>France</country></aff><aff id="af2"><label>2</label><addr-line>Metabolic Genetic Diseases Laboratory, Metabolic Research Unit</addr-line>,<institution>School of Medicine, Deakin University</institution>,<addr-line>75 Pigdons Road, Waurn Ponds, Victoria 3217</addr-line>,<country>Australia</country></aff><aff id="af3"><label>3</label><addr-line>Laboratoire EGCE UMR CNRS 9191, IRD247, Université Paris Sud</addr-line>,<institution>Université Paris Diderot Sorbonne Paris Cité</institution>,<addr-line>91198 Gif-sur-Yvette</addr-line>,<country>France</country></aff><aff id="af4"><label>4</label><institution>INRA UR 1037 SCRIBE</institution>,<addr-line>IFR 140, 35042 Rennes Cedex</addr-line>,<country>France</country></aff><author-notes><corresp id="cor1">e-mail: <email>vincent.laudet@ens-lyon.fr</email></corresp><fn fn-type="con" id="AN2"><label>†</label><p>These authors contributed equally to this study.</p></fn></author-notes><pub-date pub-type="ppub"><day>7</day><month>3</month><year>2015</year></pub-date><volume>282</volume><issue>1802</issue><elocation-id>20142764</elocation-id><history><date date-type="received"><day>11</day><month>11</month><year>2014</year></date><date date-type="accepted"><day>9</day><month>1</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 The Author(s) Published by the Royal Society. All rights reserved.</copyright-statement><copyright-year>2015</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="rspb20142764.pdf"></self-uri><abstract><p>Small variations in signalling pathways have been linked to phenotypic diversity and speciation. In vertebrates, teeth represent a reservoir of adaptive morphological structures that are prone to evolutionary change. Cyprinid fish display an impressive diversity in tooth number, but the signals that generate such diversity are unknown. Here, we show that retinoic acid (RA) availability influences tooth number size in Cyprinids. Heterozygous adult zebrafish heterozygous for the <italic>cyp26b1</italic> mutant that encodes an enzyme able to degrade RA possess an extra tooth in the ventral row. Expression analysis of pharyngeal mesenchyme markers such as <italic>dlx2a</italic> and <italic>lhx6</italic> shows lateral, anterior and dorsal expansion of these markers in RA-treated embryos, whereas the expression of the dental epithelium markers <italic>dlx2b</italic> and <italic>dlx3b</italic> is unchanged. Our analysis suggests that changes in RA signalling play an important role in the diversification of teeth in Cyprinids. Our work illustrates that through subtle changes in the expression of rate-limiting enzymes, the RA pathway is an active player of tooth evolution in fish.</p></abstract><kwd-group><kwd>retinoic acid</kwd><kwd>tooth</kwd><kwd>cyprinids</kwd><kwd>development</kwd><kwd>evolution</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>March 7, 2015</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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