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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CESA TRAFFICKING INHIBITOR Inhibits Cellulose Deposition and Interferes with the Trafficking of Cellulose Synthase Complexes and Their Associated Proteins KORRIGAN1 and POM2/CELLULOSE SYNTHASE INTERACTIVE PROTEIN1<xref ref-type="fn" rid="fn1"><sup>1</sup>
</xref>
<xref ref-type="fn" rid="fn2"><sup>[OPEN]</sup>
</xref>
</title>
<author><name sortKey="Worden, Natasha" sort="Worden, Natasha" uniqKey="Worden N" first="Natasha" last="Worden">Natasha Worden</name>
</author>
<author><name sortKey="Wilkop, Thomas E" sort="Wilkop, Thomas E" uniqKey="Wilkop T" first="Thomas E." last="Wilkop">Thomas E. Wilkop</name>
</author>
<author><name sortKey="Esteve, Victor Esteva" sort="Esteve, Victor Esteva" uniqKey="Esteve V" first="Victor Esteva" last="Esteve">Victor Esteva Esteve</name>
</author>
<author><name sortKey="Jeannotte, Richard" sort="Jeannotte, Richard" uniqKey="Jeannotte R" first="Richard" last="Jeannotte">Richard Jeannotte</name>
</author>
<author><name sortKey="Lathe, Rahul" sort="Lathe, Rahul" uniqKey="Lathe R" first="Rahul" last="Lathe">Rahul Lathe</name>
</author>
<author><name sortKey="Vernhettes, Samantha" sort="Vernhettes, Samantha" uniqKey="Vernhettes S" first="Samantha" last="Vernhettes">Samantha Vernhettes</name>
</author>
<author><name sortKey="Weimer, Bart" sort="Weimer, Bart" uniqKey="Weimer B" first="Bart" last="Weimer">Bart Weimer</name>
</author>
<author><name sortKey="Hicks, Glenn" sort="Hicks, Glenn" uniqKey="Hicks G" first="Glenn" last="Hicks">Glenn Hicks</name>
</author>
<author><name sortKey="Alonso, Jose" sort="Alonso, Jose" uniqKey="Alonso J" first="Jose" last="Alonso">Jose Alonso</name>
</author>
<author><name sortKey="Labavitch, John" sort="Labavitch, John" uniqKey="Labavitch J" first="John" last="Labavitch">John Labavitch</name>
</author>
<author><name sortKey="Persson, Staffan" sort="Persson, Staffan" uniqKey="Persson S" first="Staffan" last="Persson">Staffan Persson</name>
</author>
<author><name sortKey="Ehrhardt, David" sort="Ehrhardt, David" uniqKey="Ehrhardt D" first="David" last="Ehrhardt">David Ehrhardt</name>
</author>
<author><name sortKey="Drakakaki, Georgia" sort="Drakakaki, Georgia" uniqKey="Drakakaki G" first="Georgia" last="Drakakaki">Georgia Drakakaki</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25535279</idno>
<idno type="pmc">4326758</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326758</idno>
<idno type="RBID">PMC:4326758</idno>
<idno type="doi">10.1104/pp.114.249003</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">001A78</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001A78</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">CESA TRAFFICKING INHIBITOR Inhibits Cellulose Deposition and Interferes with the Trafficking of Cellulose Synthase Complexes and Their Associated Proteins KORRIGAN1 and POM2/CELLULOSE SYNTHASE INTERACTIVE PROTEIN1<xref ref-type="fn" rid="fn1"><sup>1</sup>
</xref>
<xref ref-type="fn" rid="fn2"><sup>[OPEN]</sup>
</xref>
</title>
<author><name sortKey="Worden, Natasha" sort="Worden, Natasha" uniqKey="Worden N" first="Natasha" last="Worden">Natasha Worden</name>
</author>
<author><name sortKey="Wilkop, Thomas E" sort="Wilkop, Thomas E" uniqKey="Wilkop T" first="Thomas E." last="Wilkop">Thomas E. Wilkop</name>
</author>
<author><name sortKey="Esteve, Victor Esteva" sort="Esteve, Victor Esteva" uniqKey="Esteve V" first="Victor Esteva" last="Esteve">Victor Esteva Esteve</name>
</author>
<author><name sortKey="Jeannotte, Richard" sort="Jeannotte, Richard" uniqKey="Jeannotte R" first="Richard" last="Jeannotte">Richard Jeannotte</name>
</author>
<author><name sortKey="Lathe, Rahul" sort="Lathe, Rahul" uniqKey="Lathe R" first="Rahul" last="Lathe">Rahul Lathe</name>
</author>
<author><name sortKey="Vernhettes, Samantha" sort="Vernhettes, Samantha" uniqKey="Vernhettes S" first="Samantha" last="Vernhettes">Samantha Vernhettes</name>
</author>
<author><name sortKey="Weimer, Bart" sort="Weimer, Bart" uniqKey="Weimer B" first="Bart" last="Weimer">Bart Weimer</name>
</author>
<author><name sortKey="Hicks, Glenn" sort="Hicks, Glenn" uniqKey="Hicks G" first="Glenn" last="Hicks">Glenn Hicks</name>
</author>
<author><name sortKey="Alonso, Jose" sort="Alonso, Jose" uniqKey="Alonso J" first="Jose" last="Alonso">Jose Alonso</name>
</author>
<author><name sortKey="Labavitch, John" sort="Labavitch, John" uniqKey="Labavitch J" first="John" last="Labavitch">John Labavitch</name>
</author>
<author><name sortKey="Persson, Staffan" sort="Persson, Staffan" uniqKey="Persson S" first="Staffan" last="Persson">Staffan Persson</name>
</author>
<author><name sortKey="Ehrhardt, David" sort="Ehrhardt, David" uniqKey="Ehrhardt D" first="David" last="Ehrhardt">David Ehrhardt</name>
</author>
<author><name sortKey="Drakakaki, Georgia" sort="Drakakaki, Georgia" uniqKey="Drakakaki G" first="Georgia" last="Drakakaki">Georgia Drakakaki</name>
</author>
</analytic>
<series><title level="j">Plant Physiology</title>
<idno type="ISSN">0032-0889</idno>
<idno type="eISSN">1532-2548</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The compound CESTRIN reduces cellulose content and inhibits the trafficking of CESA in Arabidopsis hypocotyls.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Plant Physiol</journal-id>
<journal-id journal-id-type="iso-abbrev">Plant Physiol</journal-id>
<journal-id journal-id-type="hwp">plantphysiol</journal-id>
<journal-id journal-id-type="publisher-id">aspb</journal-id>
<journal-title-group><journal-title>Plant Physiology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0032-0889</issn>
<issn pub-type="epub">1532-2548</issn>
<publisher><publisher-name>American Society of Plant Biologists</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25535279</article-id>
<article-id pub-id-type="pmc">4326758</article-id>
<article-id pub-id-type="publisher-id">249003</article-id>
<article-id pub-id-type="doi">10.1104/pp.114.249003</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Articles</subject>
<subj-group subj-group-type="heading"><subject>Cell Biology</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>CESA TRAFFICKING INHIBITOR Inhibits Cellulose Deposition and Interferes with the Trafficking of Cellulose Synthase Complexes and Their Associated Proteins KORRIGAN1 and POM2/CELLULOSE SYNTHASE INTERACTIVE PROTEIN1<xref ref-type="fn" rid="fn1"><sup>1</sup>
</xref>
<xref ref-type="fn" rid="fn2"><sup>[OPEN]</sup>
</xref>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-0804-2884</contrib-id>
<name><surname>Worden</surname>
<given-names>Natasha</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Wilkop</surname>
<given-names>Thomas E.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Esteve</surname>
<given-names>Victor Esteva</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Jeannotte</surname>
<given-names>Richard</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Lathe</surname>
<given-names>Rahul</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Vernhettes</surname>
<given-names>Samantha</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Weimer</surname>
<given-names>Bart</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hicks</surname>
<given-names>Glenn</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Alonso</surname>
<given-names>Jose</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Labavitch</surname>
<given-names>John</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Persson</surname>
<given-names>Staffan</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Ehrhardt</surname>
<given-names>David</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Drakakaki</surname>
<given-names>Georgia</given-names>
</name>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<aff id="aff1">Departments of Plant Sciences (N.W., T.E.W., V.E.E., J.L., G.D.) and Veterinary Medicine (R.J., B.W.), University of California, Davis, California 95616;</aff>
<aff id="aff2">Max-Planck-Institute of Molecular Plant Physiology, Science Campus, 14476 Golm, Germany (R.L., S.P.);</aff>
<aff id="aff3">Institut National de la Recherche Agronomique, Institute Jean-Pierre Bourgin, 78026 Versailles, France (S.V.);</aff>
<aff id="aff4">Department of Botany and Plant Sciences, University of California, Riverside, California 92521 (G.H.);</aff>
<aff id="aff5">Department of Plant and Microbial Biology, North Caroline State University, Raleigh, North Carolina 27695 (J.A.);</aff>
<aff id="aff6">Australian Research Council Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia (S.P.); and</aff>
<aff id="aff7">Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305 (D.E.)</aff>
</contrib-group>
<author-notes><fn><p><ext-link ext-link-type="uri" xlink:href="http://www.plantphysiol.org/cgi/doi/10.1104/pp.114.249003">www.plantphysiol.org/cgi/doi/10.1104/pp.114.249003</ext-link>
</p>
</fn>
<corresp id="cor1"><label>*</label>
Address correspondence to <email>gdrakakaki@ucdavis.edu</email>
.</corresp>
<fn id="afn1"><p>The author responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (<ext-link ext-link-type="uri" xlink:href="http://www.plantphysiol.org">www.plantphysiol.org</ext-link>
) is: Georgia Drakakaki (<email>gdrakakaki@ucdavis.edu</email>
).</p>
</fn>
</author-notes>
<pmc-comment>Fake ppub date generated by PMC from publisher pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>2</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>22</day>
<month>12</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>22</day>
<month>12</month>
<year>2014</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
. </pmc-comment>
<volume>167</volume>
<issue>2</issue>
<fpage>381</fpage>
<lpage>393</lpage>
<history><date date-type="received"><day>20</day>
<month>8</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>17</day>
<month>12</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© 2015 American Society of Plant Biologists. All Rights Reserved.</copyright-statement>
<copyright-year>2015</copyright-year>
</permissions>
<self-uri xlink:role="icon" xlink:href="PP_249003_ic1.gif"></self-uri>
<self-uri content-type="alt-lang-pdf zh" xlink:href="PP_249003.chinese.pdf"></self-uri>
<abstract abstract-type="precis"><p>The compound CESTRIN reduces cellulose content and inhibits the trafficking of CESA in Arabidopsis hypocotyls.</p>
</abstract>
<abstract><p>Cellulose synthase complexes (<xref ref-type="def" rid="def2">CSC</xref>
s) at the plasma membrane (<xref ref-type="def" rid="def1">PM</xref>
) are aligned with cortical microtubules (<xref ref-type="def" rid="def4">MT</xref>
s) and direct the biosynthesis of cellulose. The mechanism of the interaction between <xref ref-type="def" rid="def2">CSC</xref>
s and <xref ref-type="def" rid="def4">MT</xref>
s, and the cellular determinants that control the delivery of <xref ref-type="def" rid="def2">CSC</xref>
s at the <xref ref-type="def" rid="def1">PM</xref>
, are not yet well understood. We identified a unique small molecule, CESA TRAFFICKING INHIBITOR (CESTRIN), which reduces cellulose content and alters the anisotropic growth of Arabidopsis (<italic>Arabidopsis thaliana</italic>
) hypocotyls. We monitored the distribution and mobility of fluorescently labeled cellulose synthases (<xref ref-type="def" rid="def3">CESA</xref>
s) in live Arabidopsis cells under chemical exposure to characterize their subcellular effects. CESTRIN reduces the velocity of <xref ref-type="def" rid="def1">PM</xref>
<xref ref-type="def" rid="def2">CSC</xref>
s and causes their accumulation in the cell cortex. The <xref ref-type="def" rid="def2">CSC</xref>
-associated proteins KORRIGAN1 (KOR1) and POM2/CELLULOSE SYNTHASE INTERACTIVE PROTEIN1 (CSI1) were differentially affected by CESTRIN treatment, indicating different forms of association with the <xref ref-type="def" rid="def1">PM</xref>
<xref ref-type="def" rid="def2">CSC</xref>
s. KOR1 accumulated in bodies similar to <xref ref-type="def" rid="def3">CESA</xref>
; however, POM2/CSI1 dissociated into the cytoplasm. In addition, <xref ref-type="def" rid="def4">MT</xref>
stability was altered without direct inhibition of <xref ref-type="def" rid="def4">MT</xref>
polymerization, suggesting a feedback mechanism caused by cellulose interference. The selectivity of CESTRIN was assessed using a variety of subcellular markers for which no morphological effect was observed. The association of <xref ref-type="def" rid="def3">CESA</xref>
s with vesicles decorated by the trans-Golgi network-localized protein SYNTAXIN OF PLANTS61 (SYP61) was increased under CESTRIN treatment, implicating SYP61 compartments in <xref ref-type="def" rid="def3">CESA</xref>
trafficking. The properties of CESTRIN compared with known <xref ref-type="def" rid="def3">CESA</xref>
inhibitors afford unique avenues to study and understand the mechanism under which <xref ref-type="def" rid="def1">PM</xref>
-associated <xref ref-type="def" rid="def2">CSC</xref>
s are maintained and interact with <xref ref-type="def" rid="def4">MT</xref>
s and to dissect their trafficking routes in etiolated hypocotyls.</p>
</abstract>
<counts><page-count count="13"></page-count>
</counts>
<custom-meta-group><custom-meta><meta-name> DJS Export </meta-name>
<meta-value>v1</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><glossary><title>Glossary</title>
<def-list><def-item><term id="term1">PM</term>
<def id="def1"><p>plasma membrane</p>
</def>
</def-item>
<def-item><term id="term2">CSC</term>
<def id="def2"><p>cellulose synthase complex</p>
</def>
</def-item>
<def-item><term id="term3">CESA</term>
<def id="def3"><p>cellulose synthase</p>
</def>
</def-item>
<def-item><term id="term4">MT</term>
<def id="def4"><p>microtubule</p>
</def>
</def-item>
<def-item><term id="term5">ER</term>
<def id="def5"><p>endoplasmic reticulum</p>
</def>
</def-item>
<def-item><term id="term6">TGN</term>
<def id="def6"><p>trans-Golgi network</p>
</def>
</def-item>
<def-item><term id="term7">MASCs</term>
<def id="def7"><p>microtubule-associated cellulose synthase compartments</p>
</def>
</def-item>
<def-item><term id="term8">SmaCCs</term>
<def id="def8"><p>small cellulose synthase compartments</p>
</def>
</def-item>
<def-item><term id="term9">DMSO</term>
<def id="def9"><p>dimethyl sulfoxide</p>
</def>
</def-item>
<def-item><term id="term10">TFA</term>
<def id="def10"><p>trifluoroacetic acid</p>
</def>
</def-item>
<def-item><term id="term11">Col-0</term>
<def id="def11"><p>Columbia</p>
</def>
</def-item>
<def-item><term id="term12">CBI</term>
<def id="def12"><p>cellulose biosynthesis inhibitor</p>
</def>
</def-item>
<def-item><term id="term13">AGM</term>
<def id="def13"><p>Arabidopsis growth medium</p>
</def>
</def-item>
<def-item><term id="term14">YPD</term>
<def id="def14"><p>yeast extract peptone dextrose</p>
</def>
</def-item>
<def-item><term id="term15">AIR</term>
<def id="def15"><p>alcohol-insoluble residues</p>
</def>
</def-item>
<def-item><term id="term16">MS</term>
<def id="def16"><p>Murashige and Skoog</p>
</def>
</def-item>
</def-list>
</glossary>
</notes>
</front>
</pmc>
</record>
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