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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CESA TRAFFICKING INHIBITOR Inhibits Cellulose Deposition and Interferes with the Trafficking of Cellulose Synthase Complexes and Their Associated Proteins KORRIGAN1 and POM2/CELLULOSE SYNTHASE INTERACTIVE PROTEIN1<xref ref-type="fn" rid="fn1"><sup>1</sup></xref><xref ref-type="fn" rid="fn2"><sup>[OPEN]</sup></xref></title><author><name sortKey="Worden, Natasha" sort="Worden, Natasha" uniqKey="Worden N" first="Natasha" last="Worden">Natasha Worden</name></author><author><name sortKey="Wilkop, Thomas E" sort="Wilkop, Thomas E" uniqKey="Wilkop T" first="Thomas E." last="Wilkop">Thomas E. Wilkop</name></author><author><name sortKey="Esteve, Victor Esteva" sort="Esteve, Victor Esteva" uniqKey="Esteve V" first="Victor Esteva" last="Esteve">Victor Esteva Esteve</name></author><author><name sortKey="Jeannotte, Richard" sort="Jeannotte, Richard" uniqKey="Jeannotte R" first="Richard" last="Jeannotte">Richard Jeannotte</name></author><author><name sortKey="Lathe, Rahul" sort="Lathe, Rahul" uniqKey="Lathe R" first="Rahul" last="Lathe">Rahul Lathe</name></author><author><name sortKey="Vernhettes, Samantha" sort="Vernhettes, Samantha" uniqKey="Vernhettes S" first="Samantha" last="Vernhettes">Samantha Vernhettes</name></author><author><name sortKey="Weimer, Bart" sort="Weimer, Bart" uniqKey="Weimer B" first="Bart" last="Weimer">Bart Weimer</name></author><author><name sortKey="Hicks, Glenn" sort="Hicks, Glenn" uniqKey="Hicks G" first="Glenn" last="Hicks">Glenn Hicks</name></author><author><name sortKey="Alonso, Jose" sort="Alonso, Jose" uniqKey="Alonso J" first="Jose" last="Alonso">Jose Alonso</name></author><author><name sortKey="Labavitch, John" sort="Labavitch, John" uniqKey="Labavitch J" first="John" last="Labavitch">John Labavitch</name></author><author><name sortKey="Persson, Staffan" sort="Persson, Staffan" uniqKey="Persson S" first="Staffan" last="Persson">Staffan Persson</name></author><author><name sortKey="Ehrhardt, David" sort="Ehrhardt, David" uniqKey="Ehrhardt D" first="David" last="Ehrhardt">David Ehrhardt</name></author><author><name sortKey="Drakakaki, Georgia" sort="Drakakaki, Georgia" uniqKey="Drakakaki G" first="Georgia" last="Drakakaki">Georgia Drakakaki</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25535279</idno><idno type="pmc">4326758</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326758</idno><idno type="RBID">PMC:4326758</idno><idno type="doi">10.1104/pp.114.249003</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001A78</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001A78</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">CESA TRAFFICKING INHIBITOR Inhibits Cellulose Deposition and Interferes with the Trafficking of Cellulose Synthase Complexes and Their Associated Proteins KORRIGAN1 and POM2/CELLULOSE SYNTHASE INTERACTIVE PROTEIN1<xref ref-type="fn" rid="fn1"><sup>1</sup></xref><xref ref-type="fn" rid="fn2"><sup>[OPEN]</sup></xref></title><author><name sortKey="Worden, Natasha" sort="Worden, Natasha" uniqKey="Worden N" first="Natasha" last="Worden">Natasha Worden</name></author><author><name sortKey="Wilkop, Thomas E" sort="Wilkop, Thomas E" uniqKey="Wilkop T" first="Thomas E." last="Wilkop">Thomas E. Wilkop</name></author><author><name sortKey="Esteve, Victor Esteva" sort="Esteve, Victor Esteva" uniqKey="Esteve V" first="Victor Esteva" last="Esteve">Victor Esteva Esteve</name></author><author><name sortKey="Jeannotte, Richard" sort="Jeannotte, Richard" uniqKey="Jeannotte R" first="Richard" last="Jeannotte">Richard Jeannotte</name></author><author><name sortKey="Lathe, Rahul" sort="Lathe, Rahul" uniqKey="Lathe R" first="Rahul" last="Lathe">Rahul Lathe</name></author><author><name sortKey="Vernhettes, Samantha" sort="Vernhettes, Samantha" uniqKey="Vernhettes S" first="Samantha" last="Vernhettes">Samantha Vernhettes</name></author><author><name sortKey="Weimer, Bart" sort="Weimer, Bart" uniqKey="Weimer B" first="Bart" last="Weimer">Bart Weimer</name></author><author><name sortKey="Hicks, Glenn" sort="Hicks, Glenn" uniqKey="Hicks G" first="Glenn" last="Hicks">Glenn Hicks</name></author><author><name sortKey="Alonso, Jose" sort="Alonso, Jose" uniqKey="Alonso J" first="Jose" last="Alonso">Jose Alonso</name></author><author><name sortKey="Labavitch, John" sort="Labavitch, John" uniqKey="Labavitch J" first="John" last="Labavitch">John Labavitch</name></author><author><name sortKey="Persson, Staffan" sort="Persson, Staffan" uniqKey="Persson S" first="Staffan" last="Persson">Staffan Persson</name></author><author><name sortKey="Ehrhardt, David" sort="Ehrhardt, David" uniqKey="Ehrhardt D" first="David" last="Ehrhardt">David Ehrhardt</name></author><author><name sortKey="Drakakaki, Georgia" sort="Drakakaki, Georgia" uniqKey="Drakakaki G" first="Georgia" last="Drakakaki">Georgia Drakakaki</name></author></analytic><series><title level="j">Plant Physiology</title><idno type="ISSN">0032-0889</idno><idno type="eISSN">1532-2548</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The compound CESTRIN reduces cellulose content and inhibits the trafficking of CESA in Arabidopsis hypocotyls.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Plant Physiol</journal-id><journal-id journal-id-type="iso-abbrev">Plant Physiol</journal-id><journal-id journal-id-type="hwp">plantphysiol</journal-id><journal-id journal-id-type="publisher-id">aspb</journal-id><journal-title-group><journal-title>Plant Physiology</journal-title></journal-title-group><issn pub-type="ppub">0032-0889</issn><issn pub-type="epub">1532-2548</issn><publisher><publisher-name>American Society of Plant Biologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25535279</article-id><article-id pub-id-type="pmc">4326758</article-id><article-id pub-id-type="publisher-id">249003</article-id><article-id pub-id-type="doi">10.1104/pp.114.249003</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject><subj-group subj-group-type="heading"><subject>Cell Biology</subject></subj-group></subj-group></article-categories><title-group><article-title>CESA TRAFFICKING INHIBITOR Inhibits Cellulose Deposition and Interferes with the Trafficking of Cellulose Synthase Complexes and Their Associated Proteins KORRIGAN1 and POM2/CELLULOSE SYNTHASE INTERACTIVE PROTEIN1<xref ref-type="fn" rid="fn1"><sup>1</sup></xref><xref ref-type="fn" rid="fn2"><sup>[OPEN]</sup></xref></article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-0804-2884</contrib-id><name><surname>Worden</surname><given-names>Natasha</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wilkop</surname><given-names>Thomas E.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Esteve</surname><given-names>Victor Esteva</given-names></name></contrib><contrib contrib-type="author"><name><surname>Jeannotte</surname><given-names>Richard</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lathe</surname><given-names>Rahul</given-names></name></contrib><contrib contrib-type="author"><name><surname>Vernhettes</surname><given-names>Samantha</given-names></name></contrib><contrib contrib-type="author"><name><surname>Weimer</surname><given-names>Bart</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hicks</surname><given-names>Glenn</given-names></name></contrib><contrib contrib-type="author"><name><surname>Alonso</surname><given-names>Jose</given-names></name></contrib><contrib contrib-type="author"><name><surname>Labavitch</surname><given-names>John</given-names></name></contrib><contrib contrib-type="author"><name><surname>Persson</surname><given-names>Staffan</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ehrhardt</surname><given-names>David</given-names></name></contrib><contrib contrib-type="author"><name><surname>Drakakaki</surname><given-names>Georgia</given-names></name><xref ref-type="corresp" rid="cor1">*</xref></contrib><aff id="aff1">Departments of Plant Sciences (N.W., T.E.W., V.E.E., J.L., G.D.) and Veterinary Medicine (R.J., B.W.), University of California, Davis, California 95616;</aff><aff id="aff2">Max-Planck-Institute of Molecular Plant Physiology, Science Campus, 14476 Golm, Germany (R.L., S.P.);</aff><aff id="aff3">Institut National de la Recherche Agronomique, Institute Jean-Pierre Bourgin, 78026 Versailles, France (S.V.);</aff><aff id="aff4">Department of Botany and Plant Sciences, University of California, Riverside, California 92521 (G.H.);</aff><aff id="aff5">Department of Plant and Microbial Biology, North Caroline State University, Raleigh, North Carolina 27695 (J.A.);</aff><aff id="aff6">Australian Research Council Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Parkville, Victoria 3010, Australia (S.P.); and</aff><aff id="aff7">Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305 (D.E.)</aff></contrib-group><author-notes><fn><p><ext-link ext-link-type="uri" xlink:href="http://www.plantphysiol.org/cgi/doi/10.1104/pp.114.249003">www.plantphysiol.org/cgi/doi/10.1104/pp.114.249003</ext-link></p></fn><corresp id="cor1"><label>*</label>Address correspondence to <email>gdrakakaki@ucdavis.edu</email>.</corresp><fn id="afn1"><p>The author responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (<ext-link ext-link-type="uri" xlink:href="http://www.plantphysiol.org">www.plantphysiol.org</ext-link>) is: Georgia Drakakaki (<email>gdrakakaki@ucdavis.edu</email>).</p></fn></author-notes><pmc-comment>Fake ppub date generated by PMC from publisher pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>2</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>22</day><month>12</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>22</day><month>12</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>167</volume><issue>2</issue><fpage>381</fpage><lpage>393</lpage><history><date date-type="received"><day>20</day><month>8</month><year>2014</year></date><date date-type="accepted"><day>17</day><month>12</month><year>2014</year></date></history><permissions><copyright-statement>© 2015 American Society of Plant Biologists. All Rights Reserved.</copyright-statement><copyright-year>2015</copyright-year></permissions><self-uri xlink:role="icon" xlink:href="PP_249003_ic1.gif"></self-uri><self-uri content-type="alt-lang-pdf zh" xlink:href="PP_249003.chinese.pdf"></self-uri><abstract abstract-type="precis"><p>The compound CESTRIN reduces cellulose content and inhibits the trafficking of CESA in Arabidopsis hypocotyls.</p></abstract><abstract><p>Cellulose synthase complexes (<xref ref-type="def" rid="def2">CSC</xref>s) at the plasma membrane (<xref ref-type="def" rid="def1">PM</xref>) are aligned with cortical microtubules (<xref ref-type="def" rid="def4">MT</xref>s) and direct the biosynthesis of cellulose. The mechanism of the interaction between <xref ref-type="def" rid="def2">CSC</xref>s and <xref ref-type="def" rid="def4">MT</xref>s, and the cellular determinants that control the delivery of <xref ref-type="def" rid="def2">CSC</xref>s at the <xref ref-type="def" rid="def1">PM</xref>, are not yet well understood. We identified a unique small molecule, CESA TRAFFICKING INHIBITOR (CESTRIN), which reduces cellulose content and alters the anisotropic growth of Arabidopsis (<italic>Arabidopsis thaliana</italic>) hypocotyls. We monitored the distribution and mobility of fluorescently labeled cellulose synthases (<xref ref-type="def" rid="def3">CESA</xref>s) in live Arabidopsis cells under chemical exposure to characterize their subcellular effects. CESTRIN reduces the velocity of <xref ref-type="def" rid="def1">PM</xref><xref ref-type="def" rid="def2">CSC</xref>s and causes their accumulation in the cell cortex. The <xref ref-type="def" rid="def2">CSC</xref>-associated proteins KORRIGAN1 (KOR1) and POM2/CELLULOSE SYNTHASE INTERACTIVE PROTEIN1 (CSI1) were differentially affected by CESTRIN treatment, indicating different forms of association with the <xref ref-type="def" rid="def1">PM</xref><xref ref-type="def" rid="def2">CSC</xref>s. KOR1 accumulated in bodies similar to <xref ref-type="def" rid="def3">CESA</xref>; however, POM2/CSI1 dissociated into the cytoplasm. In addition, <xref ref-type="def" rid="def4">MT</xref> stability was altered without direct inhibition of <xref ref-type="def" rid="def4">MT</xref> polymerization, suggesting a feedback mechanism caused by cellulose interference. The selectivity of CESTRIN was assessed using a variety of subcellular markers for which no morphological effect was observed. The association of <xref ref-type="def" rid="def3">CESA</xref>s with vesicles decorated by the trans-Golgi network-localized protein SYNTAXIN OF PLANTS61 (SYP61) was increased under CESTRIN treatment, implicating SYP61 compartments in <xref ref-type="def" rid="def3">CESA</xref> trafficking. The properties of CESTRIN compared with known <xref ref-type="def" rid="def3">CESA</xref> inhibitors afford unique avenues to study and understand the mechanism under which <xref ref-type="def" rid="def1">PM</xref>-associated <xref ref-type="def" rid="def2">CSC</xref>s are maintained and interact with <xref ref-type="def" rid="def4">MT</xref>s and to dissect their trafficking routes in etiolated hypocotyls.</p></abstract><counts><page-count count="13"></page-count></counts><custom-meta-group><custom-meta><meta-name> DJS Export </meta-name><meta-value>v1</meta-value></custom-meta></custom-meta-group></article-meta><notes><glossary><title>Glossary</title><def-list><def-item><term id="term1">PM</term><def id="def1"><p>plasma membrane</p></def></def-item><def-item><term id="term2">CSC</term><def id="def2"><p>cellulose synthase complex</p></def></def-item><def-item><term id="term3">CESA</term><def id="def3"><p>cellulose synthase</p></def></def-item><def-item><term id="term4">MT</term><def id="def4"><p>microtubule</p></def></def-item><def-item><term id="term5">ER</term><def id="def5"><p>endoplasmic reticulum</p></def></def-item><def-item><term id="term6">TGN</term><def id="def6"><p>trans-Golgi network</p></def></def-item><def-item><term id="term7">MASCs</term><def id="def7"><p>microtubule-associated cellulose synthase compartments</p></def></def-item><def-item><term id="term8">SmaCCs</term><def id="def8"><p>small cellulose synthase compartments</p></def></def-item><def-item><term id="term9">DMSO</term><def id="def9"><p>dimethyl sulfoxide</p></def></def-item><def-item><term id="term10">TFA</term><def id="def10"><p>trifluoroacetic acid</p></def></def-item><def-item><term id="term11">Col-0</term><def id="def11"><p>Columbia</p></def></def-item><def-item><term id="term12">CBI</term><def id="def12"><p>cellulose biosynthesis inhibitor</p></def></def-item><def-item><term id="term13">AGM</term><def id="def13"><p>Arabidopsis growth medium</p></def></def-item><def-item><term id="term14">YPD</term><def id="def14"><p>yeast extract peptone dextrose</p></def></def-item><def-item><term id="term15">AIR</term><def id="def15"><p>alcohol-insoluble residues</p></def></def-item><def-item><term id="term16">MS</term><def id="def16"><p>Murashige and Skoog</p></def></def-item></def-list></glossary></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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