Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dietary supplementation with polyunsaturated fatty acid during pregnancy modulates DNA methylation at <italic>IGF2/H19</italic> imprinted genes and growth of infants</title><author><name sortKey="Lee, Ho Sun" sort="Lee, Ho Sun" uniqKey="Lee H" first="Ho-Sun" last="Lee">Ho-Sun Lee</name><affiliation><nlm:aff id="aff1">Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, France,</nlm:aff></affiliation></author><author><name sortKey="Barraza Villarreal, Albino" sort="Barraza Villarreal, Albino" uniqKey="Barraza Villarreal A" first="Albino" last="Barraza-Villarreal">Albino Barraza-Villarreal</name><affiliation><nlm:aff id="aff2">Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México,</nlm:aff></affiliation></author><author><name sortKey="Biessy, Carine" sort="Biessy, Carine" uniqKey="Biessy C" first="Carine" last="Biessy">Carine Biessy</name><affiliation><nlm:aff id="aff3">Nutritional Epidemiology Group, IARC, Lyon, France;</nlm:aff></affiliation></author><author><name sortKey="Duarte Salles, Talita" sort="Duarte Salles, Talita" uniqKey="Duarte Salles T" first="Talita" last="Duarte-Salles">Talita Duarte-Salles</name><affiliation><nlm:aff id="aff3">Nutritional Epidemiology Group, IARC, Lyon, France;</nlm:aff></affiliation></author><author><name sortKey="Sly, Peter D" sort="Sly, Peter D" uniqKey="Sly P" first="Peter D." last="Sly">Peter D. Sly</name><affiliation><nlm:aff wicri:cut=", and" id="aff4">Queensland Children's Medical Research Institute, Royal Children's Hospital, Herston, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Ramakrishnan, Usha" sort="Ramakrishnan, Usha" uniqKey="Ramakrishnan U" first="Usha" last="Ramakrishnan">Usha Ramakrishnan</name><affiliation><nlm:aff id="aff5">Nutrition and Health Sciences and the Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia</nlm:aff></affiliation></author><author><name sortKey="Rivera, Juan" sort="Rivera, Juan" uniqKey="Rivera J" first="Juan" last="Rivera">Juan Rivera</name><affiliation><nlm:aff id="aff2">Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México,</nlm:aff></affiliation></author><author><name sortKey="Herceg, Zdenko" sort="Herceg, Zdenko" uniqKey="Herceg Z" first="Zdenko" last="Herceg">Zdenko Herceg</name><affiliation><nlm:aff id="aff1">Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, France,</nlm:aff></affiliation></author><author><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name><affiliation><nlm:aff id="aff2">Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México,</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Nutrition and Health Sciences and the Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25293351</idno><idno type="pmc">4254937</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254937</idno><idno type="RBID">PMC:4254937</idno><idno type="doi">10.1152/physiolgenomics.00061.2014</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001A51</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001A51</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dietary supplementation with polyunsaturated fatty acid during pregnancy modulates DNA methylation at <italic>IGF2/H19</italic> imprinted genes and growth of infants</title><author><name sortKey="Lee, Ho Sun" sort="Lee, Ho Sun" uniqKey="Lee H" first="Ho-Sun" last="Lee">Ho-Sun Lee</name><affiliation><nlm:aff id="aff1">Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, France,</nlm:aff></affiliation></author><author><name sortKey="Barraza Villarreal, Albino" sort="Barraza Villarreal, Albino" uniqKey="Barraza Villarreal A" first="Albino" last="Barraza-Villarreal">Albino Barraza-Villarreal</name><affiliation><nlm:aff id="aff2">Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México,</nlm:aff></affiliation></author><author><name sortKey="Biessy, Carine" sort="Biessy, Carine" uniqKey="Biessy C" first="Carine" last="Biessy">Carine Biessy</name><affiliation><nlm:aff id="aff3">Nutritional Epidemiology Group, IARC, Lyon, France;</nlm:aff></affiliation></author><author><name sortKey="Duarte Salles, Talita" sort="Duarte Salles, Talita" uniqKey="Duarte Salles T" first="Talita" last="Duarte-Salles">Talita Duarte-Salles</name><affiliation><nlm:aff id="aff3">Nutritional Epidemiology Group, IARC, Lyon, France;</nlm:aff></affiliation></author><author><name sortKey="Sly, Peter D" sort="Sly, Peter D" uniqKey="Sly P" first="Peter D." last="Sly">Peter D. Sly</name><affiliation><nlm:aff wicri:cut=", and" id="aff4">Queensland Children's Medical Research Institute, Royal Children's Hospital, Herston, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Ramakrishnan, Usha" sort="Ramakrishnan, Usha" uniqKey="Ramakrishnan U" first="Usha" last="Ramakrishnan">Usha Ramakrishnan</name><affiliation><nlm:aff id="aff5">Nutrition and Health Sciences and the Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia</nlm:aff></affiliation></author><author><name sortKey="Rivera, Juan" sort="Rivera, Juan" uniqKey="Rivera J" first="Juan" last="Rivera">Juan Rivera</name><affiliation><nlm:aff id="aff2">Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México,</nlm:aff></affiliation></author><author><name sortKey="Herceg, Zdenko" sort="Herceg, Zdenko" uniqKey="Herceg Z" first="Zdenko" last="Herceg">Zdenko Herceg</name><affiliation><nlm:aff id="aff1">Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, France,</nlm:aff></affiliation></author><author><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name><affiliation><nlm:aff id="aff2">Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México,</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Nutrition and Health Sciences and the Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia</nlm:aff></affiliation></author></analytic><series><title level="j">Physiological Genomics</title><idno type="ISSN">1094-8341</idno><idno type="eISSN">1531-2267</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Epigenetic regulation of imprinted genes is regarded as a highly plausible explanation for linking dietary exposures in early life with the onset of diseases during childhood and adulthood. We sought to test whether prenatal dietary supplementation with docosahexaenoic acid (DHA) during pregnancy may modulate epigenetic states at birth. This study was based on a randomized intervention trial conducted in Mexican pregnant women supplemented daily with 400 mg of DHA or a placebo from gestation <italic>week 18–22</italic> to parturition. We applied quantitative profiling of DNA methylation states at <italic>IGF2</italic> promoter 3 (<italic>IGF2</italic> P3), <italic>IGF2</italic> differentially methylated region (DMR), and <italic>H19</italic> DMR in cord blood mononuclear cells of the DHA-supplemented group (<italic>n</italic> = 131) and the control group (<italic>n</italic> = 130). In stratified analyses, DNA methylation levels in <italic>IGF2</italic> P3 were significantly higher in the DHA group than the control group in preterm infants (<italic>P</italic> = 0.04). We also observed a positive association between DNA methylation levels and maternal body mass index; <italic>IGF2</italic> DMR methylation was higher in the DHA group than the control group in infants of overweight mothers (<italic>P</italic> = 0.03). In addition, at <italic>H19</italic> DMR, methylation levels were significantly lower in the DHA group than the control group in infants of normal weight mothers (<italic>P</italic> = 0.01). Finally, methylation levels at <italic>IGF2/H19</italic> imprinted regions were associated with maternal BMI. These findings suggest that epigenetic mechanisms may be modulated by DHA, with potential impacts on child growth and development.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Physiol Genomics</journal-id><journal-id journal-id-type="iso-abbrev">Physiol. Genomics</journal-id><journal-id journal-id-type="hwp">physiolgenomics</journal-id><journal-id journal-id-type="pmc">physiolgenomics</journal-id><journal-id journal-id-type="publisher-id">PHYSIOLGENOMICS</journal-id><journal-title-group><journal-title>Physiological Genomics</journal-title></journal-title-group><issn pub-type="ppub">1094-8341</issn><issn pub-type="epub">1531-2267</issn><publisher><publisher-name>American Physiological Society</publisher-name><publisher-loc>Bethesda, MD</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25293351</article-id><article-id pub-id-type="pmc">4254937</article-id><article-id pub-id-type="publisher-id">PG-00061-2014</article-id><article-id pub-id-type="doi">10.1152/physiolgenomics.00061.2014</article-id><article-categories><subj-group subj-group-type="heading"><subject>Nutrient Gene Interaction</subject></subj-group></article-categories><title-group><article-title>Dietary supplementation with polyunsaturated fatty acid during pregnancy modulates DNA methylation at <italic>IGF2/H19</italic> imprinted genes and growth of infants</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Ho-Sun</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Barraza-Villarreal</surname><given-names>Albino</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Biessy</surname><given-names>Carine</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Duarte-Salles</surname><given-names>Talita</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sly</surname><given-names>Peter D.</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ramakrishnan</surname><given-names>Usha</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rivera</surname><given-names>Juan</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Herceg</surname><given-names>Zdenko</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn1">*</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Romieu</surname><given-names>Isabelle</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref><xref ref-type="author-notes" rid="fn1">*</xref></contrib><aff id="aff1"><sup>1</sup>Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, France,</aff><aff id="aff2"><sup>2</sup>Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México,</aff><aff id="aff3"><sup>3</sup>Nutritional Epidemiology Group, IARC, Lyon, France;</aff><aff id="aff4"><sup>4</sup>Queensland Children's Medical Research Institute, Royal Children's Hospital, Herston, Queensland, Australia, and</aff><aff id="aff5"><sup>5</sup>Nutrition and Health Sciences and the Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia</aff></contrib-group><author-notes><fn id="fn1" fn-type="equal"><label>*</label><p>Z. Herceg and I. Romieu contributed equally to this work.</p></fn><corresp id="cor1">Address for reprint requests and other correspondence: I. Romieu, <addr-line>International Agency for Research on Cancer, Nutritional Epidemiology Group, 150, cours Albert Thomas, Lyon, 69372, France</addr-line> (e-mail: <email>romieui@iarc.fr</email>).</corresp></author-notes><pub-date pub-type="epub"><day>7</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>12</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>12</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>46</volume><issue>23</issue><fpage>851</fpage><lpage>857</lpage><history><date date-type="received"><day>30</day><month>5</month><year>2014</year></date><date date-type="accepted"><day>4</day><month>10</month><year>2014</year></date></history><permissions><copyright-statement>Copyright © 2014 the American Physiological Society</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>American Physiological Society</copyright-holder></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zh702314000851.pdf"></self-uri><abstract><p>Epigenetic regulation of imprinted genes is regarded as a highly plausible explanation for linking dietary exposures in early life with the onset of diseases during childhood and adulthood. We sought to test whether prenatal dietary supplementation with docosahexaenoic acid (DHA) during pregnancy may modulate epigenetic states at birth. This study was based on a randomized intervention trial conducted in Mexican pregnant women supplemented daily with 400 mg of DHA or a placebo from gestation <italic>week 18–22</italic> to parturition. We applied quantitative profiling of DNA methylation states at <italic>IGF2</italic> promoter 3 (<italic>IGF2</italic> P3), <italic>IGF2</italic> differentially methylated region (DMR), and <italic>H19</italic> DMR in cord blood mononuclear cells of the DHA-supplemented group (<italic>n</italic> = 131) and the control group (<italic>n</italic> = 130). In stratified analyses, DNA methylation levels in <italic>IGF2</italic> P3 were significantly higher in the DHA group than the control group in preterm infants (<italic>P</italic> = 0.04). We also observed a positive association between DNA methylation levels and maternal body mass index; <italic>IGF2</italic> DMR methylation was higher in the DHA group than the control group in infants of overweight mothers (<italic>P</italic> = 0.03). In addition, at <italic>H19</italic> DMR, methylation levels were significantly lower in the DHA group than the control group in infants of normal weight mothers (<italic>P</italic> = 0.01). Finally, methylation levels at <italic>IGF2/H19</italic> imprinted regions were associated with maternal BMI. These findings suggest that epigenetic mechanisms may be modulated by DHA, with potential impacts on child growth and development.</p></abstract><kwd-group><kwd>epigenetics</kwd><kwd>DHA supplementation</kwd><kwd>pregnancy</kwd><kwd>imprinted genes</kwd><kwd>maternal BMI</kwd><kwd>IGF2</kwd><kwd>H19</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A519 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001A519 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |