Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Distinct Forms of Mitochondrial TOM-TIM Supercomplexes Define Signal-Dependent States of Preprotein Sorting<xref ref-type="fn" rid="fn1">▿</xref> </title><author><name sortKey="Chacinska, Agnieszka" sort="Chacinska, Agnieszka" uniqKey="Chacinska A" first="Agnieszka" last="Chacinska">Agnieszka Chacinska</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Van Der Laan, Martin" sort="Van Der Laan, Martin" uniqKey="Van Der Laan M" first="Martin" last="Van Der Laan">Martin Van Der Laan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mehnert, Carola S" sort="Mehnert, Carola S" uniqKey="Mehnert C" first="Carola S." last="Mehnert">Carola S. Mehnert</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Guiard, Bernard" sort="Guiard, Bernard" uniqKey="Guiard B" first="Bernard" last="Guiard">Bernard Guiard</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mick, David U" sort="Mick, David U" uniqKey="Mick D" first="David U." last="Mick">David U. Mick</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hutu, Dana P" sort="Hutu, Dana P" uniqKey="Hutu D" first="Dana P." last="Hutu">Dana P. Hutu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Truscott, Kaye N" sort="Truscott, Kaye N" uniqKey="Truscott K" first="Kaye N." last="Truscott">Kaye N. Truscott</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wiedemann, Nils" sort="Wiedemann, Nils" uniqKey="Wiedemann N" first="Nils" last="Wiedemann">Nils Wiedemann</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Meisinger, Chris" sort="Meisinger, Chris" uniqKey="Meisinger C" first="Chris" last="Meisinger">Chris Meisinger</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Pfanner, Nikolaus" sort="Pfanner, Nikolaus" uniqKey="Pfanner N" first="Nikolaus" last="Pfanner">Nikolaus Pfanner</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Rehling, Peter" sort="Rehling, Peter" uniqKey="Rehling P" first="Peter" last="Rehling">Peter Rehling</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19884344</idno><idno type="pmc">2798301</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798301</idno><idno type="RBID">PMC:2798301</idno><idno type="doi">10.1128/MCB.00749-09</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">001A24</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001A24</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Distinct Forms of Mitochondrial TOM-TIM Supercomplexes Define Signal-Dependent States of Preprotein Sorting<xref ref-type="fn" rid="fn1">▿</xref> </title><author><name sortKey="Chacinska, Agnieszka" sort="Chacinska, Agnieszka" uniqKey="Chacinska A" first="Agnieszka" last="Chacinska">Agnieszka Chacinska</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Van Der Laan, Martin" sort="Van Der Laan, Martin" uniqKey="Van Der Laan M" first="Martin" last="Van Der Laan">Martin Van Der Laan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mehnert, Carola S" sort="Mehnert, Carola S" uniqKey="Mehnert C" first="Carola S." last="Mehnert">Carola S. Mehnert</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Guiard, Bernard" sort="Guiard, Bernard" uniqKey="Guiard B" first="Bernard" last="Guiard">Bernard Guiard</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mick, David U" sort="Mick, David U" uniqKey="Mick D" first="David U." last="Mick">David U. Mick</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hutu, Dana P" sort="Hutu, Dana P" uniqKey="Hutu D" first="Dana P." last="Hutu">Dana P. Hutu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Truscott, Kaye N" sort="Truscott, Kaye N" uniqKey="Truscott K" first="Kaye N." last="Truscott">Kaye N. Truscott</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wiedemann, Nils" sort="Wiedemann, Nils" uniqKey="Wiedemann N" first="Nils" last="Wiedemann">Nils Wiedemann</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Meisinger, Chris" sort="Meisinger, Chris" uniqKey="Meisinger C" first="Chris" last="Meisinger">Chris Meisinger</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Pfanner, Nikolaus" sort="Pfanner, Nikolaus" uniqKey="Pfanner N" first="Nikolaus" last="Pfanner">Nikolaus Pfanner</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Rehling, Peter" sort="Rehling, Peter" uniqKey="Rehling P" first="Peter" last="Rehling">Peter Rehling</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Molecular and Cellular Biology</title><idno type="ISSN">0270-7306</idno><idno type="eISSN">1098-5549</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Mitochondrial import of cleavable preproteins occurs at translocation contact sites, where the translocase of the outer membrane (TOM) associates with the presequence translocase of the inner membrane (TIM23) in a supercomplex. Different views exist on the mechanism of how TIM23 mediates preprotein sorting to either the matrix or inner membrane. On the one hand, two TIM23 forms were proposed, a matrix transport form containing the presequence translocase-associated motor (PAM; TIM23-PAM) and a sorting form containing Tim21 (TIM23<sup>SORT</sup>). On the other hand, it was reported that TIM23 and PAM are permanently associated in a single-entity translocase. We have accumulated distinct transport intermediates of preproteins to analyze the translocases in their active, preprotein-carrying state. We identified two different forms of active TOM-TIM23 supercomplexes, TOM-TIM23<sup>SORT</sup> and TOM-TIM23-PAM. These two supercomplexes do not represent separate pathways but are in dynamic exchange during preprotein translocation and sorting. Depending on the signals of the preproteins, switches between the different forms of supercomplex and TIM23 are required for the completion of preprotein import.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Mol Cell Biol</journal-id><journal-id journal-id-type="publisher-id">molcellb</journal-id><journal-title-group><journal-title>Molecular and Cellular Biology</journal-title></journal-title-group><issn pub-type="ppub">0270-7306</issn><issn pub-type="epub">1098-5549</issn><publisher><publisher-name>American Society for Microbiology (ASM)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19884344</article-id><article-id pub-id-type="pmc">2798301</article-id><article-id pub-id-type="publisher-id">0749-09</article-id><article-id pub-id-type="doi">10.1128/MCB.00749-09</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Distinct Forms of Mitochondrial TOM-TIM Supercomplexes Define Signal-Dependent States of Preprotein Sorting<xref ref-type="fn" rid="fn1">▿</xref> </article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chacinska</surname><given-names>Agnieszka</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>van der Laan</surname><given-names>Martin</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mehnert</surname><given-names>Carola S.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Guiard</surname><given-names>Bernard</given-names></name><xref ref-type="aff" rid="aff1">4</xref></contrib><contrib contrib-type="author"><name><surname>Mick</surname><given-names>David U.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">3</xref><xref ref-type="aff" rid="aff1">5</xref></contrib><contrib contrib-type="author"><name><surname>Hutu</surname><given-names>Dana P.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">3</xref><xref ref-type="aff" rid="aff1">5</xref></contrib><contrib contrib-type="author"><name><surname>Truscott</surname><given-names>Kaye N.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">6</xref></contrib><contrib contrib-type="author"><name><surname>Wiedemann</surname><given-names>Nils</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Meisinger</surname><given-names>Chris</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Pfanner</surname><given-names>Nikolaus</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Rehling</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">5</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="aff1">Institut für Biochemie und Molekularbiologie, ZBMZ, Universität Freiburg, 79104 Freiburg, Germany,<label>1</label> Centre for Biological Signalling Studies (bioss), Universität Freiburg, 79104 Freiburg, Germany,<label>2</label> Fakultät für Biologie, Universität Freiburg, 79104 Freiburg, Germany,<label>3</label> Centre de Génétique Moléculaire, CNRS, 91190 Gif-sur-Yvette, France,<label>4</label> Abteilung für Biochemie II, Universität Göttingen, 37073 Göttingen, Germany,<label>5</label> Department of Biochemistry, La Trobe University, Melbourne 3086, Australia<label>6</label></aff><author-notes><corresp id="cor1"><label>*</label>Corresponding author. Mailing adress for Nikolaus Pfanner: Institut für Biochemie und Molekularbiologie, ZBMZ, Stefan-Meier-Straße 17, 79104 Freiburg, Germany. Phone: 49 761 2035224. Fax: 49 761 2035261. E-mail: <email>nikolaus.pfanner@biochemie.uni-freiburg.de</email>. Mailing address for Peter Rehling: Abteilung für Biochemie II, Universität Göttingen, Humboldtallee 23, 37073 Göttingen, Germany. Phone: 49 551 395947. Fax: 49 551 395979. E-mail: <email>peter.rehling@medizin.uni-goettingen.de</email></corresp></author-notes><pub-date pub-type="ppub"><month>1</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>2</day><month>11</month><year>2009</year></pub-date><volume>30</volume><issue>1</issue><fpage>307</fpage><lpage>318</lpage><history><date date-type="received"><day>10</day><month>6</month><year>2009</year></date><date date-type="rev-recd"><day>23</day><month>7</month><year>2009</year></date><date date-type="accepted"><day>23</day><month>10</month><year>2009</year></date></history><permissions><copyright-statement>Copyright © 2010, American Society for Microbiology</copyright-statement><copyright-year>2010</copyright-year></permissions><self-uri xlink:title="pdf" xlink:href="zmb00110000307.pdf"></self-uri><abstract><p>Mitochondrial import of cleavable preproteins occurs at translocation contact sites, where the translocase of the outer membrane (TOM) associates with the presequence translocase of the inner membrane (TIM23) in a supercomplex. Different views exist on the mechanism of how TIM23 mediates preprotein sorting to either the matrix or inner membrane. On the one hand, two TIM23 forms were proposed, a matrix transport form containing the presequence translocase-associated motor (PAM; TIM23-PAM) and a sorting form containing Tim21 (TIM23<sup>SORT</sup>). On the other hand, it was reported that TIM23 and PAM are permanently associated in a single-entity translocase. We have accumulated distinct transport intermediates of preproteins to analyze the translocases in their active, preprotein-carrying state. We identified two different forms of active TOM-TIM23 supercomplexes, TOM-TIM23<sup>SORT</sup> and TOM-TIM23-PAM. These two supercomplexes do not represent separate pathways but are in dynamic exchange during preprotein translocation and sorting. Depending on the signals of the preproteins, switches between the different forms of supercomplex and TIM23 are required for the completion of preprotein import.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A24 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001A24 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |