Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impact of Prevalent Fractures on Quality of Life: Baseline Results From the Global Longitudinal Study of Osteoporosis in Women</title><author><name sortKey="Adachi, Jonathan D" sort="Adachi, Jonathan D" uniqKey="Adachi J" first="Jonathan D." last="Adachi">Jonathan D. Adachi</name></author><author><name sortKey="Adami, Silvano" sort="Adami, Silvano" uniqKey="Adami S" first="Silvano" last="Adami">Silvano Adami</name></author><author><name sortKey="Gehlbach, Stephen" sort="Gehlbach, Stephen" uniqKey="Gehlbach S" first="Stephen" last="Gehlbach">Stephen Gehlbach</name></author><author><name sortKey="Anderson, Frederick A" sort="Anderson, Frederick A" uniqKey="Anderson F" first="Frederick A." last="Anderson">Frederick A. Anderson</name></author><author><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name></author><author><name sortKey="Chapurlat, Roland D" sort="Chapurlat, Roland D" uniqKey="Chapurlat R" first="Roland D." last="Chapurlat">Roland D. Chapurlat</name></author><author><name sortKey="Compston, Juliet E" sort="Compston, Juliet E" uniqKey="Compston J" first="Juliet E." last="Compston">Juliet E. Compston</name></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name></author><author><name sortKey="Delmas, Pierre" sort="Delmas, Pierre" uniqKey="Delmas P" first="Pierre" last="Delmas">Pierre Delmas</name></author><author><name sortKey="Diez Perez, Adolfo" sort="Diez Perez, Adolfo" uniqKey="Diez Perez A" first="Adolfo" last="Díez-Pérez">Adolfo Díez-Pérez</name></author><author><name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L." last="Greenspan">Susan L. Greenspan</name></author><author><name sortKey="Hooven, Frederick H" sort="Hooven, Frederick H" uniqKey="Hooven F" first="Frederick H." last="Hooven">Frederick H. Hooven</name></author><author><name sortKey="Lacroix, Andrea Z" sort="Lacroix, Andrea Z" uniqKey="Lacroix A" first="Andrea Z." last="Lacroix">Andrea Z. Lacroix</name></author><author><name sortKey="Lindsay, Robert" sort="Lindsay, Robert" uniqKey="Lindsay R" first="Robert" last="Lindsay">Robert Lindsay</name></author><author><name sortKey="Netelenbos, J Coen" sort="Netelenbos, J Coen" uniqKey="Netelenbos J" first="J. Coen" last="Netelenbos">J. Coen Netelenbos</name></author><author><name sortKey="Wu, Olivia" sort="Wu, Olivia" uniqKey="Wu O" first="Olivia" last="Wu">Olivia Wu</name></author><author><name sortKey="Pfeilschifter, Johannes" sort="Pfeilschifter, Johannes" uniqKey="Pfeilschifter J" first="Johannes" last="Pfeilschifter">Johannes Pfeilschifter</name></author><author><name sortKey="Roux, Christian" sort="Roux, Christian" uniqKey="Roux C" first="Christian" last="Roux">Christian Roux</name></author><author><name sortKey="Saag, Kenneth G" sort="Saag, Kenneth G" uniqKey="Saag K" first="Kenneth G." last="Saag">Kenneth G. Saag</name></author><author><name sortKey="Sambrook, Philip N" sort="Sambrook, Philip N" uniqKey="Sambrook P" first="Philip N." last="Sambrook">Philip N. Sambrook</name></author><author><name sortKey="Silverman, Stuart" sort="Silverman, Stuart" uniqKey="Silverman S" first="Stuart" last="Silverman">Stuart Silverman</name></author><author><name sortKey="Siris, Ethel S" sort="Siris, Ethel S" uniqKey="Siris E" first="Ethel S." last="Siris">Ethel S. Siris</name></author><author><name sortKey="Nika, Grigor" sort="Nika, Grigor" uniqKey="Nika G" first="Grigor" last="Nika">Grigor Nika</name></author><author><name sortKey="Watts, Nelson B" sort="Watts, Nelson B" uniqKey="Watts N" first="Nelson B." last="Watts">Nelson B. Watts</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20634496</idno><idno type="pmc">2931616</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931616</idno><idno type="RBID">PMC:2931616</idno><idno type="doi">10.4065/mcp.2010.0082</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">001A21</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001A21</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Impact of Prevalent Fractures on Quality of Life: Baseline Results From the Global Longitudinal Study of Osteoporosis in Women</title><author><name sortKey="Adachi, Jonathan D" sort="Adachi, Jonathan D" uniqKey="Adachi J" first="Jonathan D." last="Adachi">Jonathan D. Adachi</name></author><author><name sortKey="Adami, Silvano" sort="Adami, Silvano" uniqKey="Adami S" first="Silvano" last="Adami">Silvano Adami</name></author><author><name sortKey="Gehlbach, Stephen" sort="Gehlbach, Stephen" uniqKey="Gehlbach S" first="Stephen" last="Gehlbach">Stephen Gehlbach</name></author><author><name sortKey="Anderson, Frederick A" sort="Anderson, Frederick A" uniqKey="Anderson F" first="Frederick A." last="Anderson">Frederick A. Anderson</name></author><author><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name></author><author><name sortKey="Chapurlat, Roland D" sort="Chapurlat, Roland D" uniqKey="Chapurlat R" first="Roland D." last="Chapurlat">Roland D. Chapurlat</name></author><author><name sortKey="Compston, Juliet E" sort="Compston, Juliet E" uniqKey="Compston J" first="Juliet E." last="Compston">Juliet E. Compston</name></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name></author><author><name sortKey="Delmas, Pierre" sort="Delmas, Pierre" uniqKey="Delmas P" first="Pierre" last="Delmas">Pierre Delmas</name></author><author><name sortKey="Diez Perez, Adolfo" sort="Diez Perez, Adolfo" uniqKey="Diez Perez A" first="Adolfo" last="Díez-Pérez">Adolfo Díez-Pérez</name></author><author><name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L." last="Greenspan">Susan L. Greenspan</name></author><author><name sortKey="Hooven, Frederick H" sort="Hooven, Frederick H" uniqKey="Hooven F" first="Frederick H." last="Hooven">Frederick H. Hooven</name></author><author><name sortKey="Lacroix, Andrea Z" sort="Lacroix, Andrea Z" uniqKey="Lacroix A" first="Andrea Z." last="Lacroix">Andrea Z. Lacroix</name></author><author><name sortKey="Lindsay, Robert" sort="Lindsay, Robert" uniqKey="Lindsay R" first="Robert" last="Lindsay">Robert Lindsay</name></author><author><name sortKey="Netelenbos, J Coen" sort="Netelenbos, J Coen" uniqKey="Netelenbos J" first="J. Coen" last="Netelenbos">J. Coen Netelenbos</name></author><author><name sortKey="Wu, Olivia" sort="Wu, Olivia" uniqKey="Wu O" first="Olivia" last="Wu">Olivia Wu</name></author><author><name sortKey="Pfeilschifter, Johannes" sort="Pfeilschifter, Johannes" uniqKey="Pfeilschifter J" first="Johannes" last="Pfeilschifter">Johannes Pfeilschifter</name></author><author><name sortKey="Roux, Christian" sort="Roux, Christian" uniqKey="Roux C" first="Christian" last="Roux">Christian Roux</name></author><author><name sortKey="Saag, Kenneth G" sort="Saag, Kenneth G" uniqKey="Saag K" first="Kenneth G." last="Saag">Kenneth G. Saag</name></author><author><name sortKey="Sambrook, Philip N" sort="Sambrook, Philip N" uniqKey="Sambrook P" first="Philip N." last="Sambrook">Philip N. Sambrook</name></author><author><name sortKey="Silverman, Stuart" sort="Silverman, Stuart" uniqKey="Silverman S" first="Stuart" last="Silverman">Stuart Silverman</name></author><author><name sortKey="Siris, Ethel S" sort="Siris, Ethel S" uniqKey="Siris E" first="Ethel S." last="Siris">Ethel S. Siris</name></author><author><name sortKey="Nika, Grigor" sort="Nika, Grigor" uniqKey="Nika G" first="Grigor" last="Nika">Grigor Nika</name></author><author><name sortKey="Watts, Nelson B" sort="Watts, Nelson B" uniqKey="Watts N" first="Nelson B." last="Watts">Nelson B. Watts</name></author></analytic><series><title level="j">Mayo Clinic Proceedings</title><idno type="ISSN">0025-6196</idno><idno type="eISSN">1942-5546</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P28">OBJECTIVE: To examine several dimensions of health-related quality of life (HRQL) in postmenopausal women who report previous fractures, and to provide perspective by comparing these findings with those in other chronic conditions (diabetes, arthritis, lung disease).</p><p id="P29">PATIENTS AND METHODS: Fractures are a major cause of morbidity among older women. Few studies have examined HRQL in women who have had prior fractures and the effect of prior fracture location on HRQL. In this observational study of 57,141 postmenopausal women aged 55 years and older (enrollment from December 2007 to March 2009) from 17 study sites in 10 countries, HRQL was measured using the European Quality of Life 5 Dimensions Index (EQ-5D) and the health status, physical function, and vitality questions of the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36).</p><p id="P30">RESULTS: Reductions in EQ-5D health-utility scores and SF-36–measured health status, physical function, and vitality were seen in association with 9 of 10 fracture locations. Spine, hip, and upper leg fractures resulted in the greatest reductions in quality of life (EQ-5D scores, 0.62, 0.64, and 0.61, respectively, vs 0.79 without prior fracture). Women with fractures at any of these 3 locations, as well as women with a history of multiple fractures (EQ-5D scores, 0.74 for 1 prior fracture, 0.68 for 2, and 0.58 for ≥3), had reductions in HRQL that were similar to or worse than those in women with other chronic diseases (0.67 for diabetes, 0.69 for arthritis, and 0.71 for lung disease).</p><p id="P31">CONCLUSION: Previous fractures at a variety of bone locations, particularly spine, hip, and upper leg, or involving more than 1 location are associated with significant reductions in quality of life.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Mayo Clin Proc</journal-id><journal-id journal-id-type="hwp">mayoclinproc</journal-id><journal-title-group><journal-title>Mayo Clinic Proceedings</journal-title></journal-title-group><issn pub-type="ppub">0025-6196</issn><issn pub-type="epub">1942-5546</issn><publisher><publisher-name>Mayo Foundation for Medical Education and Research</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20634496</article-id><article-id pub-id-type="pmc">2931616</article-id><article-id pub-id-type="doi">10.4065/mcp.2010.0082</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Impact of Prevalent Fractures on Quality of Life: Baseline Results From the Global Longitudinal Study of Osteoporosis in Women</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Adachi</surname><given-names>Jonathan D.</given-names></name><degrees>MD</degrees><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Adami</surname><given-names>Silvano</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Gehlbach</surname><given-names>Stephen</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Anderson</surname><given-names>Frederick A.</given-names><suffix>Jr</suffix></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Boonen</surname><given-names>Steven</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Chapurlat</surname><given-names>Roland D.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Compston</surname><given-names>Juliet E.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Cooper</surname><given-names>Cyrus</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Delmas</surname><given-names>Pierre</given-names></name><degrees>MD</degrees><xref ref-type="author-notes" rid="fn1">*</xref></contrib><contrib contrib-type="author"><name><surname>Díez-Pérez</surname><given-names>Adolfo</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Greenspan</surname><given-names>Susan L.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Hooven</surname><given-names>Frederick H.</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>LaCroix</surname><given-names>Andrea Z.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Lindsay</surname><given-names>Robert</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Netelenbos</surname><given-names>J. Coen</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Olivia</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Pfeilschifter</surname><given-names>Johannes</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Roux</surname><given-names>Christian</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Saag</surname><given-names>Kenneth G.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Sambrook</surname><given-names>Philip N.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Silverman</surname><given-names>Stuart</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Siris</surname><given-names>Ethel S.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Nika</surname><given-names>Grigor</given-names></name><degrees>MS</degrees></contrib><contrib contrib-type="author"><name><surname>Watts</surname><given-names>Nelson B.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><collab>for the GLOW Investigators</collab></contrib></contrib-group><aff>From St. Joseph's Hospital, McMaster University, Hamilton, Ontario (J.D.A.); Department of Rheumatology, University of Verona, Ospedale, Verona, Valeggio, Italy (S.A.); Center for Outcomes Research, University of Massachusetts Medical School, Worcester (S.G., F.A.A., F.H.H., G.N.); Division of Geriatric Medicine, Leuven University Center for Metabolic Bone Diseases, Katholieke Universiteit Leuven, Leuven, Belgium (S.B.); Division of Rheumatology, INSERM U831, Université de Lyon, Hôpital E. Herriot, Lyon, France (R.D.C., P.D.); University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK (J.E.C.); MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital and Norman Collisson Chair of Musculoskeletal Sciences, University of Oxford, Oxford, UK (C.C.); Hospital del Mar-IMIM-Autonomous University of Barcelona, Barcelona, Spain (A.D.-P.); University of Pittsburgh, Pittsburgh, PA (S.L.G.); Fred Hutchinson Cancer Research Center, Seattle, WA (A.Z.L.); Regional Bone Center, Helen Hayes Hospital, West Haverstraw, NY (R.L.); Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands (J.C.N.); Division of Community Based Sciences, Faculty of Medicine, University of Glasgow, Scotland, UK (O.W.); Department of Internal Medicine III, Alfried Krupp Krankenhaus, Essen, Germany (J.P.); Paris Descartes University, Cochin Hospital, Paris, France (C.R.); Division of Clinical Immunology and Rheumatology, University of Alabama-Birmingham, Birmingham (K.G.S.); University of Sydney Royal North Shore Hospital, St. Leonards, Sydney, NSW, Australia (P.N.S.); Department of Rheumatology, David Geffen School of Medicine, Los Angeles, CA (S.S.); Columbia University Medical Center, New York, NY (E.S.S.); and Bone Health and Osteoporosis Center, University of Cincinnati, Cincinnati, OH (N.B.W.)</aff><author-notes><fn id="fn1"><label>*</label><p id="P1">Deceased.</p></fn><fn fn-type="supported-by" id="fn2"><p id="P2">Financial support for the GLOW study is provided by Warner Chilcott Co, LLC and Sanofi-Aventis to the Center for Outcomes Research, University of Massachusetts Medical School. Dr Boonen is senior clinical investigator of the Fund for Scientific Research, Flanders, Belgium (FWO-Vlaanderen) and holder of the Leuven University Chair in Metabolic Bone Diseases. Individual disclosures can be found on page 812.</p></fn><corresp id="cor1">Individual reprints of this article are not available. Address correspondence to Jonathan D. Adachi, MD, St. Joseph's Hospital, McMaster University, 501-25 Charlton Ave E, Hamilton, Ontario, L8N 1Y2, Canada (<email>jd.adachi@sympatico.ca</email>).
</corresp><fn fn-type="supported-by" id="fn3"><p id="P3"><bold>I<sc>ndividual</sc> D<sc>isclosures for</sc> A<sc>uthors</sc></bold></p><p id="P4">Dr Adachi: Consultant/speaker: Amgen, AstraZeneca, Lilly, GlaxoSmithKline, Merck, Novartis, Nycomed, Pfizer, Proctor & Gamble, Roche, Sanofi-Aventis, Servier, Wyeth, Bristol-Myers Squibb. Clinical trials: Amgen, Lilly, GlaxoSmithKline, Merck, Novartis, Pfizer, Proctor & Gamble, Roche, Sanofi-Aventis, Wyeth, Bristol-Myers Squibb. Clinical trials: Stock: nothing to declare.</p><p id="P5">Dr Adami: Speakers' bureau: Merck Sharp & Dohme, Lilly, Roche, Proctor & Gamble, Novartis. Honoraria: Merck Sharp & Dohme, Roche, Proctor & Gamble. Consultant/advisory board: Merck Sharp & Dohme, Amgen.</p><p id="P6">Dr Gehlbach: The Alliance for Better Bone Health (Sanofi-Aventis and Warner Chilcott).</p><p id="P7">Dr Anderson: Research grant: Sanofi-Aventis: GRACE, GLOW, ENDORSE; The Medicines Company; STAT. Scios: Orthopedic Registry. Consultant/advisory board: Sanofi-Aventis, Scios, GlaxoSmithKline, The Medicines Company, Millennium Pharmaceuticals.</p><p id="P8">Dr Boonen: Research grant: Amgen, Lilly, Novartis, Pfizer, Proctor & Gamble, Sanofi-Aventis, Roche, GlaxoSmithKline. Speakers' bureau: Amgen, Lilly, Merck, Novartis, Proctor & Gamble, Sanofi-Aventis, Servier. Honoraria: Amgen, Lilly, Merck, Novartis, Proctor & Gamble, Sanofi-Aventis, Servier. Consultant/advisory board: Amgen, Lilly, Merck, Novartis, Proctor & Gamble, Sanofi-Aventis, Servier.</p><p id="P9">Dr Chapurlat: Research grant: French Ministry of Health, Servier, Lilly, Proctor & Gamble. Speakers' bureau: none. Honoraria: Servier, Novartis, Lilly, Roche, Sanofi-Aventis, Maxence Pharma. Consultant/advisory board: Servier, Nycomed, Novartis, Maxence Pharma.</p><p id="P10">Dr Compston: Paid consultancy work: Servier, Shire, Nycomed, Novartis, Amgen, Proctor & Gamble, Wyeth, Pfizer, The Alliance for Better Bone Health (Sanofi-Aventis and Warner Chilcott), Roche, GlaxoSmithKline. Paid speaking engagements, reimbursement, and travel and accommodation: Servier, Proctor & Gamble, Lilly. Research grants: Servier R&D and Proctor & Gamble. No stocks or shares in relevant companies.</p><p id="P11">Dr Cooper: Received consulting fees and lectured for Amgen, The Alliance for Better Bone Health (Sanofi-Aventis and Warner Chilcott), Lilly, Merck Sharp & Dohme, Servier, Novartis, and Roche-GSK.</p><p id="P12">Dr Delmas: None</p><p id="P13">Dr Diez-Perez: Honoraria: Novartis, Lilly, Amgen, Proctor & Gamble, Roche. Expert witness: Merck. Consultant/advisory board: Novartis, Lilly, Amgen, Proctor & Gamble.</p><p id="P14">Dr Greenspan: Consultant/advisory board: Amgen, Lilly, Merck. Research grants: The Alliance for Better Bone Health (Sanofi-Aventis and Warner Chilcott), Lilly.</p><p id="P15">Dr Hooven: The Alliance for Better Bone Health (Sanofi-Aventis and Warner Chilcott).</p><p id="P16">Dr LaCroix: The Alliance for Better Bone Health (Sanofi-Aventis and Warner Chilcott).</p><p id="P17">Dr Lindsay: The Alliance for Better Bone Health (Sanofi-Aventis and Warner Chilcott).</p><p id="P18">Dr Netelenbos: Paid consultancy work: Roche Diagnostics, Daiichi-Sankyo, Proctor & Gamble, Nycomed. Paid speaking engagements, reimbursement, and travel and accommodation: Roche Diagnostics, Novartis, Daiichi-Sankyo, Proctor & Gamble. Research grants: The Alliance for Better Bone Health (Sanofi-Aventis and Warner Chilcott), Amgen.</p><p id="P19">Dr Wu: Research grant: Center for Outcomes Research (which in turn received funding from Sanofi-Aventis and The Medicines Company).</p><p id="P20">Dr Pfeilschifter: Research grant: Amgen, Kyphon, Novartis, Roche. Other research support: Equipment: GE Lunar. Speakers' bureau: Amgen, Sanofi-Aventis, GlaxoSmithKline, Roche, Lilly Deutschland, Orion Pharma, Merck Sharp & Dohme, Merckle, Nycomed, Proctor & Gamble. Advisory board: Novartis, Roche, Proctor & Gamble, Teva.</p><p id="P21">Dr Roux: Honoraria: The Alliance for Better Bone Health (Sanofi-Aventis and Warner Chilcott), Amgen, Lilly, Merck Sharp & Dohme, Novartis, Nycomed, Roche, GlaxoSmithKline, Servier, Wyeth. Consultant/advisory board: The Alliance for Better Bone Health (Sanofi-Aventis and Warner Chilcott), Amgen, Lilly, Merck Sharp & Dohme, Novartis, Nycomed, Roche, GlaxoSmithKline, Servier, Wyeth.</p><p id="P22">Dr Saag: Speakers' bureau: Novartis. Consulting fees or other remuneration: Lilly, Merck, Novartis, Amgen, Roche, Proctor & Gamble, Sanofi-Aventis. Paid research: Lilly, Merck, Novartis, Amgen, Proctor & Gamble, Sanofi-Aventis. Advisory committee or other paid committee: Lilly.</p><p id="P23">Dr Sambrook: Honoraria: Merck, Sanofi-Aventis, Roche, Servier. Consultant/advisory board: Merck, Sanofi-Aventis, Roche, Servier.</p><p id="P24">Dr Silverman: Research grants: Wyeth, Lilly, Novartis, The Alliance for Better Bone Health (Sanofi-Aventis and Warner Chilcott). Speakers' bureau: Lilly, Novartis, Pfizer, Proctor & Gamble. Honoraria: Proctor & Gamble. Consultant/advisory board: Lilly, Amgen, Wyeth, Merck, Roche, Novartis.</p><p id="P25">Dr Siris: Speakers' bureau: Lilly, Merck, Proctor & Gamble, Sanofi-Aventis, Novartis.</p><p id="P26">Dr Watts: Stock options/holdings, royalties, company owner, patent owner, official role: none. Honoraria for lectures in past year: Amgen, Novartis, Proctor & Gamble, Sanofi-Aventis. Consulting in past year: Amgen, Baxter, InteKrin, Johnson & Johnson, MannKind, Novo Nordisk, NPS, Pfizer, Proctor & Gamble, Sanofi-Aventis, Takeda Pharmaceuticals, Warner Chilcott. Research support (through University): Amgen, Lilly, Merck, NPS.</p></fn></author-notes><pub-date pub-type="ppub"><month>9</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><month>9</month><year>2010</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>85</volume><issue>9</issue><fpage>806</fpage><lpage>813</lpage><permissions><copyright-statement>© 2010 Mayo Foundation for Medical Education and Research</copyright-statement><copyright-year>2010</copyright-year><license license-type="open-access"><license-p>This article is freely available on publication, because the authors have chosen the immediate access option.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="806.pdf"></self-uri><abstract><p id="P28">OBJECTIVE: To examine several dimensions of health-related quality of life (HRQL) in postmenopausal women who report previous fractures, and to provide perspective by comparing these findings with those in other chronic conditions (diabetes, arthritis, lung disease).</p><p id="P29">PATIENTS AND METHODS: Fractures are a major cause of morbidity among older women. Few studies have examined HRQL in women who have had prior fractures and the effect of prior fracture location on HRQL. In this observational study of 57,141 postmenopausal women aged 55 years and older (enrollment from December 2007 to March 2009) from 17 study sites in 10 countries, HRQL was measured using the European Quality of Life 5 Dimensions Index (EQ-5D) and the health status, physical function, and vitality questions of the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36).</p><p id="P30">RESULTS: Reductions in EQ-5D health-utility scores and SF-36–measured health status, physical function, and vitality were seen in association with 9 of 10 fracture locations. Spine, hip, and upper leg fractures resulted in the greatest reductions in quality of life (EQ-5D scores, 0.62, 0.64, and 0.61, respectively, vs 0.79 without prior fracture). Women with fractures at any of these 3 locations, as well as women with a history of multiple fractures (EQ-5D scores, 0.74 for 1 prior fracture, 0.68 for 2, and 0.58 for ≥3), had reductions in HRQL that were similar to or worse than those in women with other chronic diseases (0.67 for diabetes, 0.69 for arthritis, and 0.71 for lung disease).</p><p id="P31">CONCLUSION: Previous fractures at a variety of bone locations, particularly spine, hip, and upper leg, or involving more than 1 location are associated with significant reductions in quality of life.</p></abstract><abstract abstract-type="precis"><p id="P32">This observational study of 57,141 postmenopausal women shows that previous fractures at a variety of bone locations, particularly the spine, hip, and upper leg, or involving more than 1 location are associated with significant reductions in quality of life.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A210 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001A210 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |