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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chikungunya Virus Arthritis in Adult Wild-Type Mice<xref ref-type="fn" rid="fn2">▿</xref> <xref ref-type="fn" rid="fn1">†</xref> </title><author><name sortKey="Gardner, Joy" sort="Gardner, Joy" uniqKey="Gardner J" first="Joy" last="Gardner">Joy Gardner</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Anraku, Itaru" sort="Anraku, Itaru" uniqKey="Anraku I" first="Itaru" last="Anraku">Itaru Anraku</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Le, Thuy T" sort="Le, Thuy T" uniqKey="Le T" first="Thuy T." last="Le">Thuy T. Le</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Larcher, Thibaut" sort="Larcher, Thibaut" uniqKey="Larcher T" first="Thibaut" last="Larcher">Thibaut Larcher</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Major, Lee" sort="Major, Lee" uniqKey="Major L" first="Lee" last="Major">Lee Major</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Roques, Pierre" sort="Roques, Pierre" uniqKey="Roques P" first="Pierre" last="Roques">Pierre Roques</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Schroder, Wayne A" sort="Schroder, Wayne A" uniqKey="Schroder W" first="Wayne A." last="Schroder">Wayne A. Schroder</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Higgs, Stephen" sort="Higgs, Stephen" uniqKey="Higgs S" first="Stephen" last="Higgs">Stephen Higgs</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20519386</idno><idno type="pmc">2916516</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916516</idno><idno type="RBID">PMC:2916516</idno><idno type="doi">10.1128/JVI.02603-09</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">001A19</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001A19</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Chikungunya Virus Arthritis in Adult Wild-Type Mice<xref ref-type="fn" rid="fn2">▿</xref> <xref ref-type="fn" rid="fn1">†</xref> </title><author><name sortKey="Gardner, Joy" sort="Gardner, Joy" uniqKey="Gardner J" first="Joy" last="Gardner">Joy Gardner</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Anraku, Itaru" sort="Anraku, Itaru" uniqKey="Anraku I" first="Itaru" last="Anraku">Itaru Anraku</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Le, Thuy T" sort="Le, Thuy T" uniqKey="Le T" first="Thuy T." last="Le">Thuy T. Le</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Larcher, Thibaut" sort="Larcher, Thibaut" uniqKey="Larcher T" first="Thibaut" last="Larcher">Thibaut Larcher</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Major, Lee" sort="Major, Lee" uniqKey="Major L" first="Lee" last="Major">Lee Major</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Roques, Pierre" sort="Roques, Pierre" uniqKey="Roques P" first="Pierre" last="Roques">Pierre Roques</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Schroder, Wayne A" sort="Schroder, Wayne A" uniqKey="Schroder W" first="Wayne A." last="Schroder">Wayne A. Schroder</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Higgs, Stephen" sort="Higgs, Stephen" uniqKey="Higgs S" first="Stephen" last="Higgs">Stephen Higgs</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Chikungunya virus is a mosquito-borne arthrogenic alphavirus that has recently reemerged to produce the largest epidemic ever documented for this virus. Here we describe a new adult wild-type mouse model of chikungunya virus arthritis, which recapitulates the self-limiting arthritis, tenosynovitis, and myositis seen in humans. Rheumatic disease was associated with a prolific infiltrate of monocytes, macrophages, and NK cells and the production of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-α), and gamma interferon (IFN-γ). Infection with a virus isolate from the recent Reunion Island epidemic induced significantly more mononuclear infiltrates, proinflammatory mediators, and foot swelling than did an Asian isolate from the 1960s. Primary mouse macrophages were shown to be productively infected with chikungunya virus; however, the depletion of macrophages ameliorated rheumatic disease and prolonged the viremia. Only 1 μg of an unadjuvanted, inactivated, whole-virus vaccine derived from the Asian isolate completely protected against viremia and arthritis induced by the Reunion Island isolate, illustrating that protection is not strain specific and that low levels of immunity are sufficient to mediate protection. IFN-α treatment was able to prevent arthritis only if given before infection, suggesting that IFN-α is not a viable therapy. Prior infection with Ross River virus, a related arthrogenic alphavirus, and anti-Ross River virus antibodies protected mice against chikungunya virus disease, suggesting that individuals previously exposed to Ross River virus should be protected from chikungunya virus disease. This new mouse model of chikungunya virus disease thus provides insights into pathogenesis and a simple and convenient system to test potential new interventions.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="publisher-id">jvirol</journal-id><journal-title-group><journal-title>Journal of Virology</journal-title></journal-title-group><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology (ASM)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20519386</article-id><article-id pub-id-type="pmc">2916516</article-id><article-id pub-id-type="publisher-id">2603-09</article-id><article-id pub-id-type="doi">10.1128/JVI.02603-09</article-id><article-categories><subj-group subj-group-type="heading"><subject>Pathogenesis and Immunity</subject></subj-group></article-categories><title-group><article-title>Chikungunya Virus Arthritis in Adult Wild-Type Mice<xref ref-type="fn" rid="fn2">▿</xref> <xref ref-type="fn" rid="fn1">†</xref> </article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gardner</surname><given-names>Joy</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Anraku</surname><given-names>Itaru</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Le</surname><given-names>Thuy T.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Larcher</surname><given-names>Thibaut</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Major</surname><given-names>Lee</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Roques</surname><given-names>Pierre</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Schroder</surname><given-names>Wayne A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Higgs</surname><given-names>Stephen</given-names></name><xref ref-type="aff" rid="aff1">4</xref></contrib><contrib contrib-type="author"><name><surname>Suhrbier</surname><given-names>Andreas</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">5</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="aff1">Queensland Institute of Medical Research, Australian Centre for International and Tropical Health, Brisbane, Australia,<label>1</label> Institut National de Recherche Agronomique, Unité Mixte de Recherche 703, Ecole Nationale Vétérinaire, Nantes, France,<label>2</label> CEA, Division of Immuno-Virology, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses, France,<label>3</label> Department of Pathology, University of Texas Medical Branch, Galveston, Texas,<label>4</label> Griffith Medical Research College, Griffith University, Brisbane, Australia<label>5</label></aff><author-notes><corresp id="cor1"><label>*</label>Corresponding author. Mailing address: Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029, Australia. Phone: 61-7-33620415. Fax: 61-7-33620107. E-mail: <email>andreasS@qimr.edu.au</email></corresp></author-notes><pub-date pub-type="ppub"><month>8</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>2</day><month>6</month><year>2010</year></pub-date><volume>84</volume><issue>16</issue><fpage>8021</fpage><lpage>8032</lpage><history><date date-type="received"><day>12</day><month>12</month><year>2009</year></date><date date-type="accepted"><day>25</day><month>5</month><year>2010</year></date></history><permissions><copyright-statement>Copyright © 2010, American Society for Microbiology</copyright-statement><copyright-year>2010</copyright-year></permissions><self-uri xlink:title="pdf" xlink:href="zjv01610008021.pdf"></self-uri><abstract><p>Chikungunya virus is a mosquito-borne arthrogenic alphavirus that has recently reemerged to produce the largest epidemic ever documented for this virus. Here we describe a new adult wild-type mouse model of chikungunya virus arthritis, which recapitulates the self-limiting arthritis, tenosynovitis, and myositis seen in humans. Rheumatic disease was associated with a prolific infiltrate of monocytes, macrophages, and NK cells and the production of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-α), and gamma interferon (IFN-γ). Infection with a virus isolate from the recent Reunion Island epidemic induced significantly more mononuclear infiltrates, proinflammatory mediators, and foot swelling than did an Asian isolate from the 1960s. Primary mouse macrophages were shown to be productively infected with chikungunya virus; however, the depletion of macrophages ameliorated rheumatic disease and prolonged the viremia. Only 1 μg of an unadjuvanted, inactivated, whole-virus vaccine derived from the Asian isolate completely protected against viremia and arthritis induced by the Reunion Island isolate, illustrating that protection is not strain specific and that low levels of immunity are sufficient to mediate protection. IFN-α treatment was able to prevent arthritis only if given before infection, suggesting that IFN-α is not a viable therapy. Prior infection with Ross River virus, a related arthrogenic alphavirus, and anti-Ross River virus antibodies protected mice against chikungunya virus disease, suggesting that individuals previously exposed to Ross River virus should be protected from chikungunya virus disease. This new mouse model of chikungunya virus disease thus provides insights into pathogenesis and a simple and convenient system to test potential new interventions.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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