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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Etiologic Heterogeneity Among Non-Hodgkin Lymphoma Subtypes: The InterLymph Non-Hodgkin Lymphoma Subtypes Project</title><author><name sortKey="Morton, Lindsay M" sort="Morton, Lindsay M" uniqKey="Morton L" first="Lindsay M." last="Morton">Lindsay M. Morton</name></author><author><name sortKey="Slager, Susan L" sort="Slager, Susan L" uniqKey="Slager S" first="Susan L." last="Slager">Susan L. Slager</name></author><author><name sortKey="Cerhan, James R" sort="Cerhan, James R" uniqKey="Cerhan J" first="James R." last="Cerhan">James R. Cerhan</name></author><author><name sortKey="Wang, Sophia S" sort="Wang, Sophia S" uniqKey="Wang S" first="Sophia S." last="Wang">Sophia S. Wang</name></author><author><name sortKey="Vajdic, Claire M" sort="Vajdic, Claire M" uniqKey="Vajdic C" first="Claire M." last="Vajdic">Claire M. Vajdic</name></author><author><name sortKey="Skibola, Christine F" sort="Skibola, Christine F" uniqKey="Skibola C" first="Christine F." last="Skibola">Christine F. Skibola</name></author><author><name sortKey="Bracci, Paige M" sort="Bracci, Paige M" uniqKey="Bracci P" first="Paige M." last="Bracci">Paige M. Bracci</name></author><author><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjosé">Silvia De Sanjosé</name></author><author><name sortKey="Smedby, Karin E" sort="Smedby, Karin E" uniqKey="Smedby K" first="Karin E." last="Smedby">Karin E. Smedby</name></author><author><name sortKey="Chiu, Brian C H" sort="Chiu, Brian C H" uniqKey="Chiu B" first="Brian C. H." last="Chiu">Brian C. H. Chiu</name></author><author><name sortKey="Zhang, Yawei" sort="Zhang, Yawei" uniqKey="Zhang Y" first="Yawei" last="Zhang">Yawei Zhang</name></author><author><name sortKey="Mbulaiteye, Sam M" sort="Mbulaiteye, Sam M" uniqKey="Mbulaiteye S" first="Sam M." last="Mbulaiteye">Sam M. Mbulaiteye</name></author><author><name sortKey="Monnereau, Alain" sort="Monnereau, Alain" uniqKey="Monnereau A" first="Alain" last="Monnereau">Alain Monnereau</name></author><author><name sortKey="Turner, Jennifer J" sort="Turner, Jennifer J" uniqKey="Turner J" first="Jennifer J." last="Turner">Jennifer J. Turner</name></author><author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name></author><author><name sortKey="Adami, Hans Olov" sort="Adami, Hans Olov" uniqKey="Adami H" first="Hans-Olov" last="Adami">Hans-Olov Adami</name></author><author><name sortKey="Chang, Ellen T" sort="Chang, Ellen T" uniqKey="Chang E" first="Ellen T." last="Chang">Ellen T. Chang</name></author><author><name sortKey="Glimelius, Bengt" sort="Glimelius, Bengt" uniqKey="Glimelius B" first="Bengt" last="Glimelius">Bengt Glimelius</name></author><author><name sortKey="Hjalgrim, Henrik" sort="Hjalgrim, Henrik" uniqKey="Hjalgrim H" first="Henrik" last="Hjalgrim">Henrik Hjalgrim</name></author><author><name sortKey="Melbye, Mads" sort="Melbye, Mads" uniqKey="Melbye M" first="Mads" last="Melbye">Mads Melbye</name></author><author><name sortKey="Crosignani, Paolo" sort="Crosignani, Paolo" uniqKey="Crosignani P" first="Paolo" last="Crosignani">Paolo Crosignani</name></author><author><name sortKey="Di Lollo, Simonetta" sort="Di Lollo, Simonetta" uniqKey="Di Lollo S" first="Simonetta" last="Di Lollo">Simonetta Di Lollo</name></author><author><name sortKey="Miligi, Lucia" sort="Miligi, Lucia" uniqKey="Miligi L" first="Lucia" last="Miligi">Lucia Miligi</name></author><author><name sortKey="Nanni, Oriana" sort="Nanni, Oriana" uniqKey="Nanni O" first="Oriana" last="Nanni">Oriana Nanni</name></author><author><name sortKey="Ramazzotti, Valerio" sort="Ramazzotti, Valerio" uniqKey="Ramazzotti V" first="Valerio" last="Ramazzotti">Valerio Ramazzotti</name></author><author><name sortKey="Rodella, Stefania" sort="Rodella, Stefania" uniqKey="Rodella S" first="Stefania" last="Rodella">Stefania Rodella</name></author><author><name sortKey="Costantini, Adele Seniori" sort="Costantini, Adele Seniori" uniqKey="Costantini A" first="Adele Seniori" last="Costantini">Adele Seniori Costantini</name></author><author><name sortKey="Stagnaro, Emanuele" sort="Stagnaro, Emanuele" uniqKey="Stagnaro E" first="Emanuele" last="Stagnaro">Emanuele Stagnaro</name></author><author><name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name></author><author><name sortKey="Vindigni, Carla" sort="Vindigni, Carla" uniqKey="Vindigni C" first="Carla" last="Vindigni">Carla Vindigni</name></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name></author><author><name sortKey="Becker, Nikolaus" sort="Becker, Nikolaus" uniqKey="Becker N" first="Nikolaus" last="Becker">Nikolaus Becker</name></author><author><name sortKey="Benavente, Yolanda" sort="Benavente, Yolanda" uniqKey="Benavente Y" first="Yolanda" last="Benavente">Yolanda Benavente</name></author><author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name></author><author><name sortKey="Cocco, Pierluigi" sort="Cocco, Pierluigi" uniqKey="Cocco P" first="Pierluigi" last="Cocco">Pierluigi Cocco</name></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name></author><author><name sortKey="Maynadie, Marc" sort="Maynadie, Marc" uniqKey="Maynadie M" first="Marc" last="Maynadié">Marc Maynadié</name></author><author><name sortKey="Nieters, Alexandra" sort="Nieters, Alexandra" uniqKey="Nieters A" first="Alexandra" last="Nieters">Alexandra Nieters</name></author><author><name sortKey="Staines, Anthony" sort="Staines, Anthony" uniqKey="Staines A" first="Anthony" last="Staines">Anthony Staines</name></author><author><name sortKey="Colt, Joanne S" sort="Colt, Joanne S" uniqKey="Colt J" first="Joanne S." last="Colt">Joanne S. Colt</name></author><author><name sortKey="Cozen, Wendy" sort="Cozen, Wendy" uniqKey="Cozen W" first="Wendy" last="Cozen">Wendy Cozen</name></author><author><name sortKey="Davis, Scott" sort="Davis, Scott" uniqKey="Davis S" first="Scott" last="Davis">Scott Davis</name></author><author><name sortKey="De Roos, Anneclaire J" sort="De Roos, Anneclaire J" uniqKey="De Roos A" first="Anneclaire J." last="De Roos">Anneclaire J. De Roos</name></author><author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name></author><author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name></author><author><name sortKey="Severson, Richard K" sort="Severson, Richard K" uniqKey="Severson R" first="Richard K." last="Severson">Richard K. Severson</name></author><author><name sortKey="Holly, Elizabeth A" sort="Holly, Elizabeth A" uniqKey="Holly E" first="Elizabeth A." last="Holly">Elizabeth A. Holly</name></author><author><name sortKey="Call, Timothy G" sort="Call, Timothy G" uniqKey="Call T" first="Timothy G." last="Call">Timothy G. Call</name></author><author><name sortKey="Feldman, Andrew L" sort="Feldman, Andrew L" uniqKey="Feldman A" first="Andrew L." last="Feldman">Andrew L. Feldman</name></author><author><name sortKey="Habermann, Thomas M" sort="Habermann, Thomas M" uniqKey="Habermann T" first="Thomas M." last="Habermann">Thomas M. Habermann</name></author><author><name sortKey="Liebow, Mark" sort="Liebow, Mark" uniqKey="Liebow M" first="Mark" last="Liebow">Mark Liebow</name></author><author><name sortKey="Blair, Aaron" sort="Blair, Aaron" uniqKey="Blair A" first="Aaron" last="Blair">Aaron Blair</name></author><author><name sortKey="Cantor, Kenneth P" sort="Cantor, Kenneth P" uniqKey="Cantor K" first="Kenneth P." last="Cantor">Kenneth P. Cantor</name></author><author><name sortKey="Kane, Eleanor V" sort="Kane, Eleanor V" uniqKey="Kane E" first="Eleanor V." last="Kane">Eleanor V. Kane</name></author><author><name sortKey="Lightfoot, Tracy" sort="Lightfoot, Tracy" uniqKey="Lightfoot T" first="Tracy" last="Lightfoot">Tracy Lightfoot</name></author><author><name sortKey="Roman, Eve" sort="Roman, Eve" uniqKey="Roman E" first="Eve" last="Roman">Eve Roman</name></author><author><name sortKey="Smith, Alex" sort="Smith, Alex" uniqKey="Smith A" first="Alex" last="Smith">Alex Smith</name></author><author><name sortKey="Brooks Wilson, Angela" sort="Brooks Wilson, Angela" uniqKey="Brooks Wilson A" first="Angela" last="Brooks-Wilson">Angela Brooks-Wilson</name></author><author><name sortKey="Connors, Joseph M" sort="Connors, Joseph M" uniqKey="Connors J" first="Joseph M." last="Connors">Joseph M. Connors</name></author><author><name sortKey="Gascoyne, Randy D" sort="Gascoyne, Randy D" uniqKey="Gascoyne R" first="Randy D." last="Gascoyne">Randy D. Gascoyne</name></author><author><name sortKey="Spinelli, John J" sort="Spinelli, John J" uniqKey="Spinelli J" first="John J." last="Spinelli">John J. Spinelli</name></author><author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K." last="Armstrong">Bruce K. Armstrong</name></author><author><name sortKey="Kricker, Anne" sort="Kricker, Anne" uniqKey="Kricker A" first="Anne" last="Kricker">Anne Kricker</name></author><author><name sortKey="Holford, Theodore R" sort="Holford, Theodore R" uniqKey="Holford T" first="Theodore R." last="Holford">Theodore R. Holford</name></author><author><name sortKey="Lan, Qing" sort="Lan, Qing" uniqKey="Lan Q" first="Qing" last="Lan">Qing Lan</name></author><author><name sortKey="Zheng, Tongzhang" sort="Zheng, Tongzhang" uniqKey="Zheng T" first="Tongzhang" last="Zheng">Tongzhang Zheng</name></author><author><name sortKey="Orsi, Laurent" sort="Orsi, Laurent" uniqKey="Orsi L" first="Laurent" last="Orsi">Laurent Orsi</name></author><author><name sortKey="Dal Maso, Luigino" sort="Dal Maso, Luigino" uniqKey="Dal Maso L" first="Luigino" last="Dal Maso">Luigino Dal Maso</name></author><author><name sortKey="Franceschi, Silvia" sort="Franceschi, Silvia" uniqKey="Franceschi S" first="Silvia" last="Franceschi">Silvia Franceschi</name></author><author><name sortKey="La Vecchia, Carlo" sort="La Vecchia, Carlo" uniqKey="La Vecchia C" first="Carlo" last="La Vecchia">Carlo La Vecchia</name></author><author><name sortKey="Negri, Eva" sort="Negri, Eva" uniqKey="Negri E" first="Eva" last="Negri">Eva Negri</name></author><author><name sortKey="Serraino, Diego" sort="Serraino, Diego" uniqKey="Serraino D" first="Diego" last="Serraino">Diego Serraino</name></author><author><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name></author><author><name sortKey="Levine, Alexandra" sort="Levine, Alexandra" uniqKey="Levine A" first="Alexandra" last="Levine">Alexandra Levine</name></author><author><name sortKey="Friedberg, Jonathan W" sort="Friedberg, Jonathan W" uniqKey="Friedberg J" first="Jonathan W." last="Friedberg">Jonathan W. Friedberg</name></author><author><name sortKey="Kelly, Jennifer L" sort="Kelly, Jennifer L" uniqKey="Kelly J" first="Jennifer L." last="Kelly">Jennifer L. Kelly</name></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name></author><author><name sortKey="Birmann, Brenda M" sort="Birmann, Brenda M" uniqKey="Birmann B" first="Brenda M." last="Birmann">Brenda M. Birmann</name></author><author><name sortKey="Clarke, Christina A" sort="Clarke, Christina A" uniqKey="Clarke C" first="Christina A." last="Clarke">Christina A. Clarke</name></author><author><name sortKey="Flowers, Christopher R" sort="Flowers, Christopher R" uniqKey="Flowers C" first="Christopher R." last="Flowers">Christopher R. Flowers</name></author><author><name sortKey="Foran, James M" sort="Foran, James M" uniqKey="Foran J" first="James M." last="Foran">James M. Foran</name></author><author><name sortKey="Kadin, Marshall E" sort="Kadin, Marshall E" uniqKey="Kadin M" first="Marshall E." last="Kadin">Marshall E. Kadin</name></author><author><name sortKey="Paltiel, Ora" sort="Paltiel, Ora" uniqKey="Paltiel O" first="Ora" last="Paltiel">Ora Paltiel</name></author><author><name sortKey="Weisenburger, Dennis D" sort="Weisenburger, Dennis D" uniqKey="Weisenburger D" first="Dennis D." last="Weisenburger">Dennis D. Weisenburger</name></author><author><name sortKey="Linet, Martha S" sort="Linet, Martha S" uniqKey="Linet M" first="Martha S." last="Linet">Martha S. Linet</name></author><author><name sortKey="Sampson, Joshua N" sort="Sampson, Joshua N" uniqKey="Sampson J" first="Joshua N." last="Sampson">Joshua N. Sampson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25174034</idno><idno type="pmc">4155467</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155467</idno><idno type="RBID">PMC:4155467</idno><idno type="doi">10.1093/jncimonographs/lgu013</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001984</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001984</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Etiologic Heterogeneity Among Non-Hodgkin Lymphoma Subtypes: The InterLymph Non-Hodgkin Lymphoma Subtypes Project</title><author><name sortKey="Morton, Lindsay M" sort="Morton, Lindsay M" uniqKey="Morton L" first="Lindsay M." last="Morton">Lindsay M. Morton</name></author><author><name sortKey="Slager, Susan L" sort="Slager, Susan L" uniqKey="Slager S" first="Susan L." last="Slager">Susan L. Slager</name></author><author><name sortKey="Cerhan, James R" sort="Cerhan, James R" uniqKey="Cerhan J" first="James R." last="Cerhan">James R. Cerhan</name></author><author><name sortKey="Wang, Sophia S" sort="Wang, Sophia S" uniqKey="Wang S" first="Sophia S." last="Wang">Sophia S. Wang</name></author><author><name sortKey="Vajdic, Claire M" sort="Vajdic, Claire M" uniqKey="Vajdic C" first="Claire M." last="Vajdic">Claire M. Vajdic</name></author><author><name sortKey="Skibola, Christine F" sort="Skibola, Christine F" uniqKey="Skibola C" first="Christine F." last="Skibola">Christine F. Skibola</name></author><author><name sortKey="Bracci, Paige M" sort="Bracci, Paige M" uniqKey="Bracci P" first="Paige M." last="Bracci">Paige M. Bracci</name></author><author><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjosé">Silvia De Sanjosé</name></author><author><name sortKey="Smedby, Karin E" sort="Smedby, Karin E" uniqKey="Smedby K" first="Karin E." last="Smedby">Karin E. Smedby</name></author><author><name sortKey="Chiu, Brian C H" sort="Chiu, Brian C H" uniqKey="Chiu B" first="Brian C. H." last="Chiu">Brian C. H. Chiu</name></author><author><name sortKey="Zhang, Yawei" sort="Zhang, Yawei" uniqKey="Zhang Y" first="Yawei" last="Zhang">Yawei Zhang</name></author><author><name sortKey="Mbulaiteye, Sam M" sort="Mbulaiteye, Sam M" uniqKey="Mbulaiteye S" first="Sam M." last="Mbulaiteye">Sam M. Mbulaiteye</name></author><author><name sortKey="Monnereau, Alain" sort="Monnereau, Alain" uniqKey="Monnereau A" first="Alain" last="Monnereau">Alain Monnereau</name></author><author><name sortKey="Turner, Jennifer J" sort="Turner, Jennifer J" uniqKey="Turner J" first="Jennifer J." last="Turner">Jennifer J. Turner</name></author><author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name></author><author><name sortKey="Adami, Hans Olov" sort="Adami, Hans Olov" uniqKey="Adami H" first="Hans-Olov" last="Adami">Hans-Olov Adami</name></author><author><name sortKey="Chang, Ellen T" sort="Chang, Ellen T" uniqKey="Chang E" first="Ellen T." last="Chang">Ellen T. Chang</name></author><author><name sortKey="Glimelius, Bengt" sort="Glimelius, Bengt" uniqKey="Glimelius B" first="Bengt" last="Glimelius">Bengt Glimelius</name></author><author><name sortKey="Hjalgrim, Henrik" sort="Hjalgrim, Henrik" uniqKey="Hjalgrim H" first="Henrik" last="Hjalgrim">Henrik Hjalgrim</name></author><author><name sortKey="Melbye, Mads" sort="Melbye, Mads" uniqKey="Melbye M" first="Mads" last="Melbye">Mads Melbye</name></author><author><name sortKey="Crosignani, Paolo" sort="Crosignani, Paolo" uniqKey="Crosignani P" first="Paolo" last="Crosignani">Paolo Crosignani</name></author><author><name sortKey="Di Lollo, Simonetta" sort="Di Lollo, Simonetta" uniqKey="Di Lollo S" first="Simonetta" last="Di Lollo">Simonetta Di Lollo</name></author><author><name sortKey="Miligi, Lucia" sort="Miligi, Lucia" uniqKey="Miligi L" first="Lucia" last="Miligi">Lucia Miligi</name></author><author><name sortKey="Nanni, Oriana" sort="Nanni, Oriana" uniqKey="Nanni O" first="Oriana" last="Nanni">Oriana Nanni</name></author><author><name sortKey="Ramazzotti, Valerio" sort="Ramazzotti, Valerio" uniqKey="Ramazzotti V" first="Valerio" last="Ramazzotti">Valerio Ramazzotti</name></author><author><name sortKey="Rodella, Stefania" sort="Rodella, Stefania" uniqKey="Rodella S" first="Stefania" last="Rodella">Stefania Rodella</name></author><author><name sortKey="Costantini, Adele Seniori" sort="Costantini, Adele Seniori" uniqKey="Costantini A" first="Adele Seniori" last="Costantini">Adele Seniori Costantini</name></author><author><name sortKey="Stagnaro, Emanuele" sort="Stagnaro, Emanuele" uniqKey="Stagnaro E" first="Emanuele" last="Stagnaro">Emanuele Stagnaro</name></author><author><name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name></author><author><name sortKey="Vindigni, Carla" sort="Vindigni, Carla" uniqKey="Vindigni C" first="Carla" last="Vindigni">Carla Vindigni</name></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name></author><author><name sortKey="Becker, Nikolaus" sort="Becker, Nikolaus" uniqKey="Becker N" first="Nikolaus" last="Becker">Nikolaus Becker</name></author><author><name sortKey="Benavente, Yolanda" sort="Benavente, Yolanda" uniqKey="Benavente Y" first="Yolanda" last="Benavente">Yolanda Benavente</name></author><author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name></author><author><name sortKey="Cocco, Pierluigi" sort="Cocco, Pierluigi" uniqKey="Cocco P" first="Pierluigi" last="Cocco">Pierluigi Cocco</name></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name></author><author><name sortKey="Maynadie, Marc" sort="Maynadie, Marc" uniqKey="Maynadie M" first="Marc" last="Maynadié">Marc Maynadié</name></author><author><name sortKey="Nieters, Alexandra" sort="Nieters, Alexandra" uniqKey="Nieters A" first="Alexandra" last="Nieters">Alexandra Nieters</name></author><author><name sortKey="Staines, Anthony" sort="Staines, Anthony" uniqKey="Staines A" first="Anthony" last="Staines">Anthony Staines</name></author><author><name sortKey="Colt, Joanne S" sort="Colt, Joanne S" uniqKey="Colt J" first="Joanne S." last="Colt">Joanne S. Colt</name></author><author><name sortKey="Cozen, Wendy" sort="Cozen, Wendy" uniqKey="Cozen W" first="Wendy" last="Cozen">Wendy Cozen</name></author><author><name sortKey="Davis, Scott" sort="Davis, Scott" uniqKey="Davis S" first="Scott" last="Davis">Scott Davis</name></author><author><name sortKey="De Roos, Anneclaire J" sort="De Roos, Anneclaire J" uniqKey="De Roos A" first="Anneclaire J." last="De Roos">Anneclaire J. De Roos</name></author><author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name></author><author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name></author><author><name sortKey="Severson, Richard K" sort="Severson, Richard K" uniqKey="Severson R" first="Richard K." last="Severson">Richard K. Severson</name></author><author><name sortKey="Holly, Elizabeth A" sort="Holly, Elizabeth A" uniqKey="Holly E" first="Elizabeth A." last="Holly">Elizabeth A. Holly</name></author><author><name sortKey="Call, Timothy G" sort="Call, Timothy G" uniqKey="Call T" first="Timothy G." last="Call">Timothy G. Call</name></author><author><name sortKey="Feldman, Andrew L" sort="Feldman, Andrew L" uniqKey="Feldman A" first="Andrew L." last="Feldman">Andrew L. Feldman</name></author><author><name sortKey="Habermann, Thomas M" sort="Habermann, Thomas M" uniqKey="Habermann T" first="Thomas M." last="Habermann">Thomas M. Habermann</name></author><author><name sortKey="Liebow, Mark" sort="Liebow, Mark" uniqKey="Liebow M" first="Mark" last="Liebow">Mark Liebow</name></author><author><name sortKey="Blair, Aaron" sort="Blair, Aaron" uniqKey="Blair A" first="Aaron" last="Blair">Aaron Blair</name></author><author><name sortKey="Cantor, Kenneth P" sort="Cantor, Kenneth P" uniqKey="Cantor K" first="Kenneth P." last="Cantor">Kenneth P. Cantor</name></author><author><name sortKey="Kane, Eleanor V" sort="Kane, Eleanor V" uniqKey="Kane E" first="Eleanor V." last="Kane">Eleanor V. Kane</name></author><author><name sortKey="Lightfoot, Tracy" sort="Lightfoot, Tracy" uniqKey="Lightfoot T" first="Tracy" last="Lightfoot">Tracy Lightfoot</name></author><author><name sortKey="Roman, Eve" sort="Roman, Eve" uniqKey="Roman E" first="Eve" last="Roman">Eve Roman</name></author><author><name sortKey="Smith, Alex" sort="Smith, Alex" uniqKey="Smith A" first="Alex" last="Smith">Alex Smith</name></author><author><name sortKey="Brooks Wilson, Angela" sort="Brooks Wilson, Angela" uniqKey="Brooks Wilson A" first="Angela" last="Brooks-Wilson">Angela Brooks-Wilson</name></author><author><name sortKey="Connors, Joseph M" sort="Connors, Joseph M" uniqKey="Connors J" first="Joseph M." last="Connors">Joseph M. Connors</name></author><author><name sortKey="Gascoyne, Randy D" sort="Gascoyne, Randy D" uniqKey="Gascoyne R" first="Randy D." last="Gascoyne">Randy D. Gascoyne</name></author><author><name sortKey="Spinelli, John J" sort="Spinelli, John J" uniqKey="Spinelli J" first="John J." last="Spinelli">John J. Spinelli</name></author><author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K." last="Armstrong">Bruce K. Armstrong</name></author><author><name sortKey="Kricker, Anne" sort="Kricker, Anne" uniqKey="Kricker A" first="Anne" last="Kricker">Anne Kricker</name></author><author><name sortKey="Holford, Theodore R" sort="Holford, Theodore R" uniqKey="Holford T" first="Theodore R." last="Holford">Theodore R. Holford</name></author><author><name sortKey="Lan, Qing" sort="Lan, Qing" uniqKey="Lan Q" first="Qing" last="Lan">Qing Lan</name></author><author><name sortKey="Zheng, Tongzhang" sort="Zheng, Tongzhang" uniqKey="Zheng T" first="Tongzhang" last="Zheng">Tongzhang Zheng</name></author><author><name sortKey="Orsi, Laurent" sort="Orsi, Laurent" uniqKey="Orsi L" first="Laurent" last="Orsi">Laurent Orsi</name></author><author><name sortKey="Dal Maso, Luigino" sort="Dal Maso, Luigino" uniqKey="Dal Maso L" first="Luigino" last="Dal Maso">Luigino Dal Maso</name></author><author><name sortKey="Franceschi, Silvia" sort="Franceschi, Silvia" uniqKey="Franceschi S" first="Silvia" last="Franceschi">Silvia Franceschi</name></author><author><name sortKey="La Vecchia, Carlo" sort="La Vecchia, Carlo" uniqKey="La Vecchia C" first="Carlo" last="La Vecchia">Carlo La Vecchia</name></author><author><name sortKey="Negri, Eva" sort="Negri, Eva" uniqKey="Negri E" first="Eva" last="Negri">Eva Negri</name></author><author><name sortKey="Serraino, Diego" sort="Serraino, Diego" uniqKey="Serraino D" first="Diego" last="Serraino">Diego Serraino</name></author><author><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name></author><author><name sortKey="Levine, Alexandra" sort="Levine, Alexandra" uniqKey="Levine A" first="Alexandra" last="Levine">Alexandra Levine</name></author><author><name sortKey="Friedberg, Jonathan W" sort="Friedberg, Jonathan W" uniqKey="Friedberg J" first="Jonathan W." last="Friedberg">Jonathan W. Friedberg</name></author><author><name sortKey="Kelly, Jennifer L" sort="Kelly, Jennifer L" uniqKey="Kelly J" first="Jennifer L." last="Kelly">Jennifer L. Kelly</name></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name></author><author><name sortKey="Birmann, Brenda M" sort="Birmann, Brenda M" uniqKey="Birmann B" first="Brenda M." last="Birmann">Brenda M. Birmann</name></author><author><name sortKey="Clarke, Christina A" sort="Clarke, Christina A" uniqKey="Clarke C" first="Christina A." last="Clarke">Christina A. Clarke</name></author><author><name sortKey="Flowers, Christopher R" sort="Flowers, Christopher R" uniqKey="Flowers C" first="Christopher R." last="Flowers">Christopher R. Flowers</name></author><author><name sortKey="Foran, James M" sort="Foran, James M" uniqKey="Foran J" first="James M." last="Foran">James M. Foran</name></author><author><name sortKey="Kadin, Marshall E" sort="Kadin, Marshall E" uniqKey="Kadin M" first="Marshall E." last="Kadin">Marshall E. Kadin</name></author><author><name sortKey="Paltiel, Ora" sort="Paltiel, Ora" uniqKey="Paltiel O" first="Ora" last="Paltiel">Ora Paltiel</name></author><author><name sortKey="Weisenburger, Dennis D" sort="Weisenburger, Dennis D" uniqKey="Weisenburger D" first="Dennis D." last="Weisenburger">Dennis D. Weisenburger</name></author><author><name sortKey="Linet, Martha S" sort="Linet, Martha S" uniqKey="Linet M" first="Martha S." last="Linet">Martha S. Linet</name></author><author><name sortKey="Sampson, Joshua N" sort="Sampson, Joshua N" uniqKey="Sampson J" first="Joshua N." last="Sampson">Joshua N. Sampson</name></author></analytic><series><title level="j">Journal of the National Cancer Institute. Monographs</title><idno type="ISSN">1052-6773</idno><idno type="eISSN">1745-6614</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Non-Hodgkin lymphoma (NHL) comprises biologically and clinically heterogeneous subtypes. Previously, study size has limited the ability to compare and contrast the risk factor profiles among these heterogeneous subtypes.</p></sec><sec sec-type="methods"><title>Methods</title><p>We pooled individual-level data from 17 471 NHL cases and 23 096 controls in 20 case–control studies from the International Lymphoma Epidemiology Consortium (InterLymph). We estimated the associations, measured as odds ratios, between each of 11 NHL subtypes and self-reported medical history, family history of hematologic malignancy, lifestyle factors, and occupation. We then assessed the heterogeneity of associations by evaluating the variability (<italic>Q</italic> value) of the estimated odds ratios for a given exposure among subtypes. Finally, we organized the subtypes into a hierarchical tree to identify groups that had similar risk factor profiles. Statistical significance of tree partitions was estimated by permutation-based <italic>P</italic> values (<italic>P</italic><sub>NODE</sub>).</p></sec><sec><title>Results</title><p>Risks differed statistically significantly among NHL subtypes for medical history factors (autoimmune diseases, hepatitis C virus seropositivity, eczema, and blood transfusion), family history of leukemia and multiple myeloma, alcohol consumption, cigarette smoking, and certain occupations, whereas generally homogeneous risks among subtypes were observed for family history of NHL, recreational sun exposure, hay fever, allergy, and socioeconomic status. Overall, the greatest difference in risk factors occurred between T-cell and B-cell lymphomas (<italic>P</italic><sub>NODE</sub> < 1.0×10<sup>−4</sup>), with increased risks generally restricted to T-cell lymphomas for eczema, T-cell-activating autoimmune diseases, family history of multiple myeloma, and occupation as a painter. We further observed substantial heterogeneity among B-cell lymphomas (<italic>P</italic><sub>NODE</sub> < 1.0×10<sup>−4</sup>). Increased risks for B-cell-activating autoimmune disease and hepatitis C virus seropositivity and decreased risks for alcohol consumption and occupation as a teacher generally were restricted to marginal zone lymphoma, Burkitt/Burkitt-like lymphoma/leukemia, diffuse large B-cell lymphoma, and/or lymphoplasmacytic lymphoma/Waldenström macroglobulinemia.</p></sec><sec><title>Conclusions</title><p>Using a novel approach to investigate etiologic heterogeneity among NHL subtypes, we identified risk factors that were common among subtypes as well as risk factors that appeared to be distinct among individual or a few subtypes, suggesting both subtype-specific and shared underlying mechanisms. Further research is needed to test putative mechanisms, investigate other risk factors (eg, other infections, environmental exposures, and diet), and evaluate potential joint effects with genetic susceptibility.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Natl Cancer Inst Monogr</journal-id><journal-id journal-id-type="iso-abbrev">J. Natl. Cancer Inst. Monographs</journal-id><journal-id journal-id-type="hwp">jncimono</journal-id><journal-id journal-id-type="publisher-id">jncmon</journal-id><journal-title-group><journal-title>Journal of the National Cancer Institute. Monographs</journal-title></journal-title-group><issn pub-type="ppub">1052-6773</issn><issn pub-type="epub">1745-6614</issn><publisher><publisher-name>Oxford University Press</publisher-name><publisher-loc>US</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25174034</article-id><article-id pub-id-type="pmc">4155467</article-id><article-id pub-id-type="doi">10.1093/jncimonographs/lgu013</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Etiologic Heterogeneity Among Non-Hodgkin Lymphoma Subtypes: The InterLymph Non-Hodgkin Lymphoma Subtypes Project</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Morton</surname><given-names>Lindsay M.</given-names></name><xref ref-type="corresp" rid="c2">*</xref></contrib><contrib contrib-type="author"><name><surname>Slager</surname><given-names>Susan L.</given-names></name><xref ref-type="corresp" rid="c2">*</xref></contrib><contrib contrib-type="author"><name><surname>Cerhan</surname><given-names>James R.</given-names></name><xref ref-type="corresp" rid="c2">*</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Sophia S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Vajdic</surname><given-names>Claire M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Skibola</surname><given-names>Christine F.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bracci</surname><given-names>Paige M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>de Sanjosé</surname><given-names>Silvia</given-names></name></contrib><contrib contrib-type="author"><name><surname>Smedby</surname><given-names>Karin E.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Chiu</surname><given-names>Brian C. 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Seniori</given-names></name></contrib><contrib contrib-type="author"><name><surname>Stagnaro</surname><given-names>Emanuele</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tumino</surname><given-names>Rosario</given-names></name></contrib><contrib contrib-type="author"><name><surname>Vindigni</surname><given-names>Carla</given-names></name></contrib><contrib contrib-type="author"><name><surname>Vineis</surname><given-names>Paolo</given-names></name></contrib><contrib contrib-type="author"><name><surname>Becker</surname><given-names>Nikolaus</given-names></name></contrib><contrib contrib-type="author"><name><surname>Benavente</surname><given-names>Yolanda</given-names></name></contrib><contrib contrib-type="author"><name><surname>Boffetta</surname><given-names>Paolo</given-names></name></contrib><contrib contrib-type="author"><name><surname>Brennan</surname><given-names>Paul</given-names></name></contrib><contrib contrib-type="author"><name><surname>Cocco</surname><given-names>Pierluigi</given-names></name></contrib><contrib contrib-type="author"><name><surname>Foretova</surname><given-names>Lenka</given-names></name></contrib><contrib contrib-type="author"><name><surname>Maynadié</surname><given-names>Marc</given-names></name></contrib><contrib contrib-type="author"><name><surname>Nieters</surname><given-names>Alexandra</given-names></name></contrib><contrib contrib-type="author"><name><surname>Staines</surname><given-names>Anthony</given-names></name></contrib><contrib contrib-type="author"><name><surname>Colt</surname><given-names>Joanne S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Cozen</surname><given-names>Wendy</given-names></name></contrib><contrib contrib-type="author"><name><surname>Davis</surname><given-names>Scott</given-names></name></contrib><contrib contrib-type="author"><name><surname>de Roos</surname><given-names>Anneclaire J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hartge</surname><given-names>Patricia</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rothman</surname><given-names>Nathaniel</given-names></name></contrib><contrib contrib-type="author"><name><surname>Severson</surname><given-names>Richard K.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Holly</surname><given-names>Elizabeth A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Call</surname><given-names>Timothy G.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Feldman</surname><given-names>Andrew L.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Habermann</surname><given-names>Thomas M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Liebow</surname><given-names>Mark</given-names></name></contrib><contrib contrib-type="author"><name><surname>Blair</surname><given-names>Aaron</given-names></name></contrib><contrib contrib-type="author"><name><surname>Cantor</surname><given-names>Kenneth P.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kane</surname><given-names>Eleanor V.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lightfoot</surname><given-names>Tracy</given-names></name></contrib><contrib contrib-type="author"><name><surname>Roman</surname><given-names>Eve</given-names></name></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Alex</given-names></name></contrib><contrib contrib-type="author"><name><surname>Brooks-Wilson</surname><given-names>Angela</given-names></name></contrib><contrib contrib-type="author"><name><surname>Connors</surname><given-names>Joseph M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Gascoyne</surname><given-names>Randy D.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Spinelli</surname><given-names>John J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Armstrong</surname><given-names>Bruce K.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kricker</surname><given-names>Anne</given-names></name></contrib><contrib contrib-type="author"><name><surname>Holford</surname><given-names>Theodore R.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lan</surname><given-names>Qing</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Tongzhang</given-names></name></contrib><contrib contrib-type="author"><name><surname>Orsi</surname><given-names>Laurent</given-names></name></contrib><contrib contrib-type="author"><name><surname>Dal Maso</surname><given-names>Luigino</given-names></name></contrib><contrib contrib-type="author"><name><surname>Franceschi</surname><given-names>Silvia</given-names></name></contrib><contrib contrib-type="author"><name><surname>La Vecchia</surname><given-names>Carlo</given-names></name></contrib><contrib contrib-type="author"><name><surname>Negri</surname><given-names>Eva</given-names></name></contrib><contrib contrib-type="author"><name><surname>Serraino</surname><given-names>Diego</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bernstein</surname><given-names>Leslie</given-names></name></contrib><contrib contrib-type="author"><name><surname>Levine</surname><given-names>Alexandra</given-names></name></contrib><contrib contrib-type="author"><name><surname>Friedberg</surname><given-names>Jonathan W.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kelly</surname><given-names>Jennifer L.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Berndt</surname><given-names>Sonja I.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Birmann</surname><given-names>Brenda M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Clarke</surname><given-names>Christina A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Flowers</surname><given-names>Christopher R.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Foran</surname><given-names>James M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kadin</surname><given-names>Marshall E.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Paltiel</surname><given-names>Ora</given-names></name></contrib><contrib contrib-type="author"><name><surname>Weisenburger</surname><given-names>Dennis D.</given-names></name><xref ref-type="corresp" rid="c2">*</xref></contrib><contrib contrib-type="author"><name><surname>Linet</surname><given-names>Martha S.</given-names></name><xref ref-type="corresp" rid="c2">*</xref></contrib><contrib contrib-type="author"><name><surname>Sampson</surname><given-names>Joshua N.</given-names></name><xref ref-type="corresp" rid="c2">*</xref></contrib><aff id="AF0001"><bold>Affiliations of authors:</bold><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute,</institution><addr-line>National Institutes of Health, Bethesda, MD</addr-line> (LMM, SMM, JSC, PH, NR, AB, KPC, QL, SIB, MSL, JNS);<institution>Department of Health Sciences Research (SLS, JRC, TMH), Division of Hematology (TGC), and Divison of General Internal Medicine (ML), College of Medicine, Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>;<institution>Department of Cancer Etiology, City of Hope Beckman Research Institute</institution>,<addr-line>Duarte, CA</addr-line> (SSW, LB, AL);<institution>Prince of Wales Clinical School, University of New South Wales</institution>,<addr-line>Sydney,</addr-line><country>Australia</country> (CMV);<institution>Department of Epidemiology, Comprehensive Cancer Center, University of Alabama</institution>,<addr-line>Birmingham, AL</addr-line> (CFS);<institution>Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco</institution>,<addr-line>San Francisco, CA</addr-line> (PMB, EAH);<institution>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Català d’ Oncologia, IDIBELL, L’Hospitalet de Llobregat</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,<institution>CIBER de Epidemiología y Salud Pública (CIBERESP)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country> (SdS, YB);<institution>Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country> (KES);<institution>Department of Health Studies, University of Chicago</institution>,<addr-line>Chicago, IL</addr-line> (BCHC);<institution>Department of Environmental Health Sciences (YZ, TZ) and Department of Biostatistics (TRH), Yale School of Public Health</institution>,<addr-line>New Haven, CT</addr-line>;<institution>INSERM, Centre for Research in Epidemiology and Population Health (CESP), U1018, Environmental Epidemiology of Cancer Group</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,<institution>Univ Paris Sud, UMRS 1018</institution>,<addr-line>Villejuif</addr-line>,<country>France</country> (AM, JC, LO);<institution>Registry of Hematological Malignancies in Gironde, Bergonié Institute</institution>,<addr-line>33076 Bordeaux</addr-line>,<country>France</country> (AM);<institution>Department of Histopathology, Douglass Hanly Moir Pathology, Macquarie Park, Australia, The Australian School of Advanced Medicine, Macquarie University</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country> (JJT);<institution>Department of Medical Epidemiology and Biostatistics (H-OA) and Department of Oncology and Pathology (BG), Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>;<institution>Department of Epidemiology, Harvard School of Public Health</institution>,<addr-line>Boston, MA</addr-line> (H-OA);<institution>Health Sciences Practice, Exponent, Inc.</institution>,<addr-line>Menlo Park, CA</addr-line>,<institution>Department of Health Research and Policy, Stanford University School of Medicine</institution>,<addr-line>Stanford, CA</addr-line> (ETC);<institution>Department of Radiology, Oncology and Radiation Science, Uppsala University</institution>,<addr-line>Uppsala</addr-line>,<country>Sweden</country> (BG);<institution>Department of Epidemiology Research, Statens Serum Institut</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country> (HH, MM);<institution>Epidemiology Unit, Fondazione IRCCS Istituto dei Tumori</institution>,<addr-line>Milan</addr-line>,<country>Italy</country> (PC);<institution>Department of Surgery and Translational Medicine, University of Florence</institution>,<addr-line>Florence</addr-line>,<country>Italy</country> (SdL);<institution>Unit of Occupational and Environmental Epidemiology, Cancer Prevention and Research Institute ISPO</institution>,<addr-line>Florence</addr-line>,<country>Italy</country> (LM, ASC);<institution>Biostatistics and Clinical Trials Unit—IRCCS IRST</institution>,<addr-line>Meldola</addr-line>,<country>Italy</country> (ON);<institution>Epidemiology Unit, Regina Elena National Cancer Institute</institution>,<addr-line>Rome</addr-line>,<country>Italy</country> (VR);<institution>Healthcare Development and Evaluation Unit, Agency for Health and Social Care</institution>,<addr-line>Bologna</addr-line>,<country>Italy</country> (SR);<institution>Unit of Epidemiology, Biostatistics and Clinical Trials, IRCCS AOU San Martino-IST</institution>,<addr-line>Genoa</addr-line>,<country>Italy</country> (ES);<institution>Cancer Registry and Histopathology Unit, “Civile - M.P. Arezzo” Hospital, ASP Ragusa</institution>,<addr-line>Ragusa</addr-line>,<country>Italy</country> (RT);<institution>Pathology Unit, Azienda Ospedaliera Universitaria Senese</institution>,<addr-line>Siena</addr-line>,<country>Italy</country> (CV);<institution>Cancer Epidemiology Unit, Imperial College London</institution>,<addr-line>London</addr-line>,<country>UK</country> (PV);<institution>Division of Cancer Epidemiology, German Cancer Research Center</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country> (NB);<institution>Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai</institution>,<addr-line>New York, NY</addr-line> (PBo);<institution>International Agency for Research on Cancer</institution>,<addr-line>Lyon</addr-line>,<country>France</country> (PBr, SF);<institution>Department of Public Health, Clinical and Molecular Medicine, Occupational Health Section, University of Cagliari</institution>,<addr-line>Cagliari</addr-line>,<country>Italy</country> (PC);<institution>Cancer Epidemiology & Genetics, Masaryk Memorial Cancer Institute</institution>,<addr-line>Brno</addr-line>,<country>Czech Republic</country> (LF);<institution>Biological Hematology Unit, CRB Ferdinand Cabanne, Universitary Hospital of Dijon</institution>,<addr-line>Dijon</addr-line>,<country>France</country>,<institution>EA4184, University of Burgundy</institution>,<addr-line>Dijon</addr-line>,<country>France</country> (MM);<institution>Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg</institution>,<addr-line>Freiburg</addr-line>,<country>Germany</country> (AN);<institution>School of Nursing and Human Sciences, Dublin City University</institution>,<addr-line>Dublin</addr-line>,<country>Ireland</country> (ASt);<institution>Department of Preventive Medicine and Pathology and Norris Comprehensive Cancer Center, USC Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line> (WC);<institution>Fred Hutchinson Cancer Research Center, Seattle, WA, School of Public Health University of Washington</institution>,<addr-line>Seattle, WA</addr-line> (SD);<institution>Department of Environmental and Occupational Health, Drexel University School of Public Health</institution>,<addr-line>Philadelphia, PA</addr-line> (AJdR);<institution>Department of Family Medicine and Public Health Sciences, Wayne State University</institution>,<addr-line>Detroit, MI</addr-line> (RKS); Department of Laboratory Medicine and Pathology,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line> (ALF);<institution>Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York</institution>,<addr-line>York</addr-line>,<country>UK</country> (EVK, TL, ER, ASm);<institution>Genome Sciences Centre (AB-W), Centre for Lymphoid Cancer (JMC, RDG), and Cancer Control Research (JJS), BC Cancer Agency</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country>;<institution>Department of Biomedical Physiology and Kinesiology, Simon Fraser University</institution>,<addr-line>Burnaby, BC</addr-line>,<country>Canada</country> (AB-W);<institution> Department of Pathology and Laboratory Medicine, (RDG) and School of Population and Public Health (JJS), University of British Columbia</institution>,<addr-line>Vancouver, BC</addr-line>,<country>Canada</country>;<institution>Sydney School of Public Health, University of Sydney</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country> (BKA, AK);<institution> Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS</institution>,<addr-line>Aviano</addr-line>,<country>Italy</country> (LDM, DS);<institution>Department of Epidemiology, IRCCS, Istituto di Ricerche Farmacologiche Mario Negri</institution>,<addr-line>Milan</addr-line>,<country>Italy</country> (CLV, EN);<institution>Department of Clinical Sciences and Community Health, University of Milan</institution>,<addr-line>Milan</addr-line>,<country>Italy</country> (CLV);<institution>James P. Wilmot Cancer Center, University of Rochester</institution>,<addr-line>Rochester, NY</addr-line> (JWF, JLK);<institution>Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line> (BMB);<institution>Cancer Prevention Institute of California</institution>,<addr-line>Fremont, CA</addr-line> (CAC);<institution>Winship Cancer Institute, Emory University</institution>,<addr-line>Atlanta, GA</addr-line> (CRF);<institution>Department of Cancer Biology, Mayo Clinic Cancer Center</institution>,<addr-line>Jacksonville, FL</addr-line> (JMF);<institution>Department of Dermatology, Boston University</institution>,<addr-line>Boston, MA</addr-line>,<institution>Roger Williams Medical Center</institution>,<addr-line>Providence, RI</addr-line> (MEK);<institution>Hadassah-Hebrew University</institution>,<addr-line>Jerusalem</addr-line>,<country>Israel</country> (OP);<institution>Department of Pathology, City of Hope National Medical Center</institution>,<addr-line>Duarte, CA</addr-line> (DDW).</aff></contrib-group><author-notes><corresp id="c2">*These authors contributed equally to this work.</corresp><corresp id="c1"><bold>Correspondence to:</bold> Lindsay M. Morton, PhD, Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Room 7E-454, Bethesda, MD 20892-9778 (e-mail: <email>mortonli@mail.nih.gov</email>).</corresp></author-notes><pub-date pub-type="ppub"><month>8</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>30</day><month>8</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>8</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>2014</volume><issue>48</issue><fpage>130</fpage><lpage>144</lpage><permissions><copyright-statement>Published by Oxford University Press 2014.</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><sec><title>Background</title><p>Non-Hodgkin lymphoma (NHL) comprises biologically and clinically heterogeneous subtypes. Previously, study size has limited the ability to compare and contrast the risk factor profiles among these heterogeneous subtypes.</p></sec><sec sec-type="methods"><title>Methods</title><p>We pooled individual-level data from 17 471 NHL cases and 23 096 controls in 20 case–control studies from the International Lymphoma Epidemiology Consortium (InterLymph). We estimated the associations, measured as odds ratios, between each of 11 NHL subtypes and self-reported medical history, family history of hematologic malignancy, lifestyle factors, and occupation. We then assessed the heterogeneity of associations by evaluating the variability (<italic>Q</italic> value) of the estimated odds ratios for a given exposure among subtypes. Finally, we organized the subtypes into a hierarchical tree to identify groups that had similar risk factor profiles. Statistical significance of tree partitions was estimated by permutation-based <italic>P</italic> values (<italic>P</italic><sub>NODE</sub>).</p></sec><sec><title>Results</title><p>Risks differed statistically significantly among NHL subtypes for medical history factors (autoimmune diseases, hepatitis C virus seropositivity, eczema, and blood transfusion), family history of leukemia and multiple myeloma, alcohol consumption, cigarette smoking, and certain occupations, whereas generally homogeneous risks among subtypes were observed for family history of NHL, recreational sun exposure, hay fever, allergy, and socioeconomic status. Overall, the greatest difference in risk factors occurred between T-cell and B-cell lymphomas (<italic>P</italic><sub>NODE</sub> < 1.0×10<sup>−4</sup>), with increased risks generally restricted to T-cell lymphomas for eczema, T-cell-activating autoimmune diseases, family history of multiple myeloma, and occupation as a painter. We further observed substantial heterogeneity among B-cell lymphomas (<italic>P</italic><sub>NODE</sub> < 1.0×10<sup>−4</sup>). Increased risks for B-cell-activating autoimmune disease and hepatitis C virus seropositivity and decreased risks for alcohol consumption and occupation as a teacher generally were restricted to marginal zone lymphoma, Burkitt/Burkitt-like lymphoma/leukemia, diffuse large B-cell lymphoma, and/or lymphoplasmacytic lymphoma/Waldenström macroglobulinemia.</p></sec><sec><title>Conclusions</title><p>Using a novel approach to investigate etiologic heterogeneity among NHL subtypes, we identified risk factors that were common among subtypes as well as risk factors that appeared to be distinct among individual or a few subtypes, suggesting both subtype-specific and shared underlying mechanisms. Further research is needed to test putative mechanisms, investigate other risk factors (eg, other infections, environmental exposures, and diet), and evaluate potential joint effects with genetic susceptibility.</p></sec></abstract><counts><page-count count="15"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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