Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Kunjin Virus Replicon-Based Vaccines Expressing Ebola Virus Glycoprotein GP Protect the Guinea Pig Against Lethal Ebola Virus Infection</title><author><name sortKey="Reynard, O" sort="Reynard, O" uniqKey="Reynard O" first="O." last="Reynard">O. Reynard</name><affiliation><nlm:aff id="aff1">Filovirus Laboratory, INSERM U758, Human Virology Department, Claude Bernard University Lyon-1, Université de Lyon, Ecole Normale Supérieure de Lyon</nlm:aff></affiliation></author><author><name sortKey="Mokhonov, V" sort="Mokhonov, V" uniqKey="Mokhonov V" first="V." last="Mokhonov">V. Mokhonov</name><affiliation><nlm:aff id="aff3">Centre for Infectious Disease Research, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Mokhonova, E" sort="Mokhonova, E" uniqKey="Mokhonova E" first="E." last="Mokhonova">E. Mokhonova</name><affiliation><nlm:aff id="aff3">Centre for Infectious Disease Research, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Leung, J" sort="Leung, J" uniqKey="Leung J" first="J." last="Leung">J. Leung</name><affiliation><nlm:aff id="aff3">Centre for Infectious Disease Research, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Page, A" sort="Page, A" uniqKey="Page A" first="A." last="Page">A. Page</name><affiliation><nlm:aff id="aff1">Filovirus Laboratory, INSERM U758, Human Virology Department, Claude Bernard University Lyon-1, Université de Lyon, Ecole Normale Supérieure de Lyon</nlm:aff></affiliation></author><author><name sortKey="Mateo, M" sort="Mateo, M" uniqKey="Mateo M" first="M." last="Mateo">M. Mateo</name><affiliation><nlm:aff id="aff1">Filovirus Laboratory, INSERM U758, Human Virology Department, Claude Bernard University Lyon-1, Université de Lyon, Ecole Normale Supérieure de Lyon</nlm:aff></affiliation></author><author><name sortKey="Pyankova, O" sort="Pyankova, O" uniqKey="Pyankova O" first="O." last="Pyankova">O. Pyankova</name><affiliation><nlm:aff id="aff3">Centre for Infectious Disease Research, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Georges Courbot, M C" sort="Georges Courbot, M C" uniqKey="Georges Courbot M" first="M. C." last="Georges-Courbot">M. C. Georges-Courbot</name><affiliation><nlm:aff id="aff2">Laboratoire Inserm P4 Jean Mérieux, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Raoul, H" sort="Raoul, H" uniqKey="Raoul H" first="H." last="Raoul">H. Raoul</name><affiliation><nlm:aff id="aff2">Laboratoire Inserm P4 Jean Mérieux, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Khromykh, A A" sort="Khromykh, A A" uniqKey="Khromykh A" first="A. A." last="Khromykh">A. A. Khromykh</name><affiliation><nlm:aff id="aff3">Centre for Infectious Disease Research, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Volchkov, V E" sort="Volchkov, V E" uniqKey="Volchkov V" first="V. E." last="Volchkov">V. E. Volchkov</name><affiliation><nlm:aff id="aff1">Filovirus Laboratory, INSERM U758, Human Virology Department, Claude Bernard University Lyon-1, Université de Lyon, Ecole Normale Supérieure de Lyon</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21987742</idno><idno type="pmc">3189994</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189994</idno><idno type="RBID">PMC:3189994</idno><idno type="doi">10.1093/infdis/jir347</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001969</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001969</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Kunjin Virus Replicon-Based Vaccines Expressing Ebola Virus Glycoprotein GP Protect the Guinea Pig Against Lethal Ebola Virus Infection</title><author><name sortKey="Reynard, O" sort="Reynard, O" uniqKey="Reynard O" first="O." last="Reynard">O. Reynard</name><affiliation><nlm:aff id="aff1">Filovirus Laboratory, INSERM U758, Human Virology Department, Claude Bernard University Lyon-1, Université de Lyon, Ecole Normale Supérieure de Lyon</nlm:aff></affiliation></author><author><name sortKey="Mokhonov, V" sort="Mokhonov, V" uniqKey="Mokhonov V" first="V." last="Mokhonov">V. Mokhonov</name><affiliation><nlm:aff id="aff3">Centre for Infectious Disease Research, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Mokhonova, E" sort="Mokhonova, E" uniqKey="Mokhonova E" first="E." last="Mokhonova">E. Mokhonova</name><affiliation><nlm:aff id="aff3">Centre for Infectious Disease Research, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Leung, J" sort="Leung, J" uniqKey="Leung J" first="J." last="Leung">J. Leung</name><affiliation><nlm:aff id="aff3">Centre for Infectious Disease Research, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Page, A" sort="Page, A" uniqKey="Page A" first="A." last="Page">A. Page</name><affiliation><nlm:aff id="aff1">Filovirus Laboratory, INSERM U758, Human Virology Department, Claude Bernard University Lyon-1, Université de Lyon, Ecole Normale Supérieure de Lyon</nlm:aff></affiliation></author><author><name sortKey="Mateo, M" sort="Mateo, M" uniqKey="Mateo M" first="M." last="Mateo">M. Mateo</name><affiliation><nlm:aff id="aff1">Filovirus Laboratory, INSERM U758, Human Virology Department, Claude Bernard University Lyon-1, Université de Lyon, Ecole Normale Supérieure de Lyon</nlm:aff></affiliation></author><author><name sortKey="Pyankova, O" sort="Pyankova, O" uniqKey="Pyankova O" first="O." last="Pyankova">O. Pyankova</name><affiliation><nlm:aff id="aff3">Centre for Infectious Disease Research, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Georges Courbot, M C" sort="Georges Courbot, M C" uniqKey="Georges Courbot M" first="M. C." last="Georges-Courbot">M. C. Georges-Courbot</name><affiliation><nlm:aff id="aff2">Laboratoire Inserm P4 Jean Mérieux, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Raoul, H" sort="Raoul, H" uniqKey="Raoul H" first="H." last="Raoul">H. Raoul</name><affiliation><nlm:aff id="aff2">Laboratoire Inserm P4 Jean Mérieux, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Khromykh, A A" sort="Khromykh, A A" uniqKey="Khromykh A" first="A. A." last="Khromykh">A. A. Khromykh</name><affiliation><nlm:aff id="aff3">Centre for Infectious Disease Research, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Volchkov, V E" sort="Volchkov, V E" uniqKey="Volchkov V" first="V. E." last="Volchkov">V. E. Volchkov</name><affiliation><nlm:aff id="aff1">Filovirus Laboratory, INSERM U758, Human Virology Department, Claude Bernard University Lyon-1, Université de Lyon, Ecole Normale Supérieure de Lyon</nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Pre- or postexposure treatments against the filoviral hemorrhagic fevers are currently not available for human use. We evaluated, in a guinea pig model, the immunogenic potential of Kunjin virus (KUN)–derived replicons as a vaccine candidate against Ebola virus (EBOV). Virus like particles (VLPs) containing KUN replicons expressing EBOV wild-type glycoprotein GP, membrane anchor-truncated GP (GP/Ctr), and mutated GP (D637L) with enhanced shedding capacity were generated and assayed for their protective efficacy. Immunization with KUN VLPs expressing full-length wild-type and D637L-mutated GPs but not membrane anchor–truncated GP induced dose-dependent protection against a challenge of a lethal dose of recombinant guinea pig-adapted EBOV. The surviving animals showed complete clearance of the virus. Our results demonstrate the potential for KUN replicon vectors as vaccine candidates against EBOV infection.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">J. Infect. Dis</journal-id><journal-id journal-id-type="hwp">jinfdis</journal-id><journal-id journal-id-type="publisher-id">jinfdis</journal-id><journal-title-group><journal-title>The Journal of Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">0022-1899</issn><issn pub-type="epub">1537-6613</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21987742</article-id><article-id pub-id-type="pmc">3189994</article-id><article-id pub-id-type="doi">10.1093/infdis/jir347</article-id><article-categories><subj-group subj-group-type="heading"><subject>Prophylaxis and Therapy</subject></subj-group></article-categories><title-group><article-title>Kunjin Virus Replicon-Based Vaccines Expressing Ebola Virus Glycoprotein GP Protect the Guinea Pig Against Lethal Ebola Virus Infection</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Reynard</surname><given-names>O.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mokhonov</surname><given-names>V.</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Mokhonova</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Leung</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="author-notes" rid="fn1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Page</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mateo</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Pyankova</surname><given-names>O.</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Georges-Courbot</surname><given-names>M. C.</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Raoul</surname><given-names>H.</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Khromykh</surname><given-names>A. A.</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Volchkov</surname><given-names>V. E.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Filovirus Laboratory, INSERM U758, Human Virology Department, Claude Bernard University Lyon-1, Université de Lyon, Ecole Normale Supérieure de Lyon</aff><aff id="aff2"><label>2</label>Laboratoire Inserm P4 Jean Mérieux, Lyon, France</aff><aff id="aff3"><label>3</label>Centre for Infectious Disease Research, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia</aff><author-notes><corresp>Correspondence: V. E. Volchkov, PhD, Filovirus Laboratory, INSERM U758, ENS Lyon, Claude Bernard University Lyon 1, 21, Ave Tony Garnier, 69365 Lyon Cedex 07, France (<email>viktor.volchkov@inserm.fr</email>).</corresp><fn><p>Potential conflicts of interest: none reported.</p></fn><fn><p>Presented in part: 5th European Meeting on Viral Zoonosis, St. Raphael, France, 26–29 September 2009. Abstract P39.</p></fn><fn id="fn1"><label>a</label><p>Present affiliation: National University Singapore, Singapore.</p></fn></author-notes><pub-date pub-type="ppub"><day>01</day><month>11</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>11</month><year>2012</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>204</volume><issue>Suppl 3</issue><issue-title>FILOVIRUSES</issue-title><fpage>S1060</fpage><lpage>S1065</lpage><permissions><copyright-statement>© The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><p>Pre- or postexposure treatments against the filoviral hemorrhagic fevers are currently not available for human use. We evaluated, in a guinea pig model, the immunogenic potential of Kunjin virus (KUN)–derived replicons as a vaccine candidate against Ebola virus (EBOV). Virus like particles (VLPs) containing KUN replicons expressing EBOV wild-type glycoprotein GP, membrane anchor-truncated GP (GP/Ctr), and mutated GP (D637L) with enhanced shedding capacity were generated and assayed for their protective efficacy. Immunization with KUN VLPs expressing full-length wild-type and D637L-mutated GPs but not membrane anchor–truncated GP induced dose-dependent protection against a challenge of a lethal dose of recombinant guinea pig-adapted EBOV. The surviving animals showed complete clearance of the virus. Our results demonstrate the potential for KUN replicon vectors as vaccine candidates against EBOV infection.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 0019698 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 0019698 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |