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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">High-Dose Chemotherapy With Autologous Stem-Cell Support As Adjuvant Therapy in Breast Cancer: Overview of 15 Randomized Trials</title><author><name sortKey="Berry, Donald A" sort="Berry, Donald A" uniqKey="Berry D" first="Donald A." last="Berry">Donald A. Berry</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Ueno, Naoto T" sort="Ueno, Naoto T" uniqKey="Ueno N" first="Naoto T." last="Ueno">Naoto T. Ueno</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Johnson, Marcella M" sort="Johnson, Marcella M" uniqKey="Johnson M" first="Marcella M." last="Johnson">Marcella M. Johnson</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Lei, Xiudong" sort="Lei, Xiudong" uniqKey="Lei X" first="Xiudong" last="Lei">Xiudong Lei</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Caputo, Jean" sort="Caputo, Jean" uniqKey="Caputo J" first="Jean" last="Caputo">Jean Caputo</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Rodenhuis, Sjoerd" sort="Rodenhuis, Sjoerd" uniqKey="Rodenhuis S" first="Sjoerd" last="Rodenhuis">Sjoerd Rodenhuis</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Peters, William P" sort="Peters, William P" uniqKey="Peters W" first="William P." last="Peters">William P. Peters</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Leonard, Robert C" sort="Leonard, Robert C" uniqKey="Leonard R" first="Robert C." last="Leonard">Robert C. Leonard</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Barlow, William E" sort="Barlow, William E" uniqKey="Barlow W" first="William E." last="Barlow">William E. Barlow</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Tallman, Martin S" sort="Tallman, Martin S" uniqKey="Tallman M" first="Martin S." last="Tallman">Martin S. Tallman</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Bergh, Jonas" sort="Bergh, Jonas" uniqKey="Bergh J" first="Jonas" last="Bergh">Jonas Bergh</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Nitz, Ulrike A" sort="Nitz, Ulrike A" uniqKey="Nitz U" first="Ulrike A." last="Nitz">Ulrike A. Nitz</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Gianni, Alessandro M" sort="Gianni, Alessandro M" uniqKey="Gianni A" first="Alessandro M." last="Gianni">Alessandro M. Gianni</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Basser, Russell L" sort="Basser, Russell L" uniqKey="Basser R" first="Russell L." last="Basser">Russell L. Basser</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Zander, Axel R" sort="Zander, Axel R" uniqKey="Zander A" first="Axel R." last="Zander">Axel R. Zander</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Coombes, R Charles" sort="Coombes, R Charles" uniqKey="Coombes R" first="R. Charles" last="Coombes">R. Charles Coombes</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Roche, Henri" sort="Roche, Henri" uniqKey="Roche H" first="Henri" last="Roché">Henri Roché</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Tokuda, Yutaka" sort="Tokuda, Yutaka" uniqKey="Tokuda Y" first="Yutaka" last="Tokuda">Yutaka Tokuda</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="De Vries, Elisabeth G E" sort="De Vries, Elisabeth G E" uniqKey="De Vries E" first="Elisabeth G. E." last="De Vries">Elisabeth G. E. De Vries</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Hortobagyi, Gabriel N" sort="Hortobagyi, Gabriel N" uniqKey="Hortobagyi G" first="Gabriel N." last="Hortobagyi">Gabriel N. Hortobagyi</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Crown, John P" sort="Crown, John P" uniqKey="Crown J" first="John P." last="Crown">John P. Crown</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Pedrazzoli, Paolo" sort="Pedrazzoli, Paolo" uniqKey="Pedrazzoli P" first="Paolo" last="Pedrazzoli">Paolo Pedrazzoli</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Bregni, Marco" sort="Bregni, Marco" uniqKey="Bregni M" first="Marco" last="Bregni">Marco Bregni</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Demirer, Taner" sort="Demirer, Taner" uniqKey="Demirer T" first="Taner" last="Demirer">Taner Demirer</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21768471</idno><idno type="pmc">4322115</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322115</idno><idno type="RBID">PMC:4322115</idno><idno type="doi">10.1200/JCO.2010.32.5910</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001946</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001946</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">High-Dose Chemotherapy With Autologous Stem-Cell Support As Adjuvant Therapy in Breast Cancer: Overview of 15 Randomized Trials</title><author><name sortKey="Berry, Donald A" sort="Berry, Donald A" uniqKey="Berry D" first="Donald A." last="Berry">Donald A. Berry</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Ueno, Naoto T" sort="Ueno, Naoto T" uniqKey="Ueno N" first="Naoto T." last="Ueno">Naoto T. Ueno</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Johnson, Marcella M" sort="Johnson, Marcella M" uniqKey="Johnson M" first="Marcella M." last="Johnson">Marcella M. Johnson</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Lei, Xiudong" sort="Lei, Xiudong" uniqKey="Lei X" first="Xiudong" last="Lei">Xiudong Lei</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Caputo, Jean" sort="Caputo, Jean" uniqKey="Caputo J" first="Jean" last="Caputo">Jean Caputo</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Rodenhuis, Sjoerd" sort="Rodenhuis, Sjoerd" uniqKey="Rodenhuis S" first="Sjoerd" last="Rodenhuis">Sjoerd Rodenhuis</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Peters, William P" sort="Peters, William P" uniqKey="Peters W" first="William P." last="Peters">William P. Peters</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Leonard, Robert C" sort="Leonard, Robert C" uniqKey="Leonard R" first="Robert C." last="Leonard">Robert C. Leonard</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Barlow, William E" sort="Barlow, William E" uniqKey="Barlow W" first="William E." last="Barlow">William E. Barlow</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Tallman, Martin S" sort="Tallman, Martin S" uniqKey="Tallman M" first="Martin S." last="Tallman">Martin S. Tallman</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Bergh, Jonas" sort="Bergh, Jonas" uniqKey="Bergh J" first="Jonas" last="Bergh">Jonas Bergh</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Nitz, Ulrike A" sort="Nitz, Ulrike A" uniqKey="Nitz U" first="Ulrike A." last="Nitz">Ulrike A. Nitz</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Gianni, Alessandro M" sort="Gianni, Alessandro M" uniqKey="Gianni A" first="Alessandro M." last="Gianni">Alessandro M. Gianni</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Basser, Russell L" sort="Basser, Russell L" uniqKey="Basser R" first="Russell L." last="Basser">Russell L. Basser</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Zander, Axel R" sort="Zander, Axel R" uniqKey="Zander A" first="Axel R." last="Zander">Axel R. Zander</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Coombes, R Charles" sort="Coombes, R Charles" uniqKey="Coombes R" first="R. Charles" last="Coombes">R. Charles Coombes</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Roche, Henri" sort="Roche, Henri" uniqKey="Roche H" first="Henri" last="Roché">Henri Roché</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Tokuda, Yutaka" sort="Tokuda, Yutaka" uniqKey="Tokuda Y" first="Yutaka" last="Tokuda">Yutaka Tokuda</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="De Vries, Elisabeth G E" sort="De Vries, Elisabeth G E" uniqKey="De Vries E" first="Elisabeth G. E." last="De Vries">Elisabeth G. E. De Vries</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Hortobagyi, Gabriel N" sort="Hortobagyi, Gabriel N" uniqKey="Hortobagyi G" first="Gabriel N." last="Hortobagyi">Gabriel N. Hortobagyi</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Crown, John P" sort="Crown, John P" uniqKey="Crown J" first="John P." last="Crown">John P. Crown</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Pedrazzoli, Paolo" sort="Pedrazzoli, Paolo" uniqKey="Pedrazzoli P" first="Paolo" last="Pedrazzoli">Paolo Pedrazzoli</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Bregni, Marco" sort="Bregni, Marco" uniqKey="Bregni M" first="Marco" last="Bregni">Marco Bregni</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Demirer, Taner" sort="Demirer, Taner" uniqKey="Demirer T" first="Taner" last="Demirer">Taner Demirer</name><affiliation><nlm:aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Clinical Oncology</title><idno type="ISSN">0732-183X</idno><idno type="eISSN">1527-7755</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>Adjuvant high-dose chemotherapy (HDC) with autologous hematopoietic stem-cell transplantation (AHST) for high-risk primary breast cancer has not been shown to prolong survival. Individual trials have had limited power to show overall benefit or benefits within subsets.</p></sec><sec><title>Methods</title><p>We assembled individual patient data from 15 randomized trials that compared HDC versus control therapy without stem-cell support. Prospectively defined primary end points were relapse-free survival (RFS) and overall survival (OS). We compared the effect of HDC versus control by using log-rank tests and proportional hazards regression, and we adjusted for clinically relevant covariates. Subset analyses were by age, number of positive lymph nodes, tumor size, histology, hormone receptor (HmR) status, and human epidermal growth factor receptor 2 (HER2) status.</p></sec><sec><title>Results</title><p>Of 6,210 total patients (n = 3,118, HDC; n = 3,092 control), the median age was 46 years; 69% were premenopausal, 29% were postmenopausal, and 2% were unknown menopausal status; 49.5% were HmR positive; 33.5% were HmR negative, and 17% were unknown HmR status. The median follow-up was 6 years. After analysis was adjusted for covariates, HDC was found to prolong relapse-free survival (RFS; hazard ratio [HR], 0.87; 95% CI, 0.81 to 0.93; <italic>P</italic> < .001) but not overall survival (OS; HR, 0.94; 95% CI, 0.87 to 1.02; <italic>P</italic> = .13). For OS, no covariates had statistically significant interactions with treatment effect, and no subsets evinced a significant effect of HDC. Younger patients had a significantly better RFS on HDC than did older patients.</p></sec><sec><title>Conclusion</title><p>Adjuvant HDC with AHST prolonged RFS in high-risk primary breast cancer compared with control, but this did not translate into a significant OS benefit. Whether HDC benefits patients in the context of targeted therapies is unknown.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Oncol</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Oncol</journal-id><journal-id journal-id-type="hwp">jco</journal-id><journal-id journal-id-type="pmc">jco</journal-id><journal-id journal-id-type="publisher-id">JCO</journal-id><journal-title-group><journal-title>Journal of Clinical Oncology</journal-title></journal-title-group><issn pub-type="ppub">0732-183X</issn><issn pub-type="epub">1527-7755</issn><publisher><publisher-name>American Society of Clinical Oncology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21768471</article-id><article-id pub-id-type="pmc">4322115</article-id><article-id pub-id-type="publisher-id">25910</article-id><article-id pub-id-type="doi">10.1200/JCO.2010.32.5910</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>Bc5</subject></subj-group><subj-group subj-group-type="heading"><subject>ORIGINAL REPORTS</subject><subj-group><subject>Breast Cancer</subject></subj-group></subj-group></article-categories><title-group><article-title>High-Dose Chemotherapy With Autologous Stem-Cell Support As Adjuvant Therapy in Breast Cancer: Overview of 15 Randomized Trials</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Berry</surname><given-names>Donald A.</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Ueno</surname><given-names>Naoto T.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Marcella M.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Lei</surname><given-names>Xiudong</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Caputo</surname><given-names>Jean</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Rodenhuis</surname><given-names>Sjoerd</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Peters</surname><given-names>William P.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Leonard</surname><given-names>Robert C.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Barlow</surname><given-names>William E.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Tallman</surname><given-names>Martin S.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Bergh</surname><given-names>Jonas</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Nitz</surname><given-names>Ulrike A.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Gianni</surname><given-names>Alessandro M.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Basser</surname><given-names>Russell L.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Zander</surname><given-names>Axel R.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Coombes</surname><given-names>R. Charles</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Roché</surname><given-names>Henri</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Tokuda</surname><given-names>Yutaka</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>de Vries</surname><given-names>Elisabeth G.E.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Hortobagyi</surname><given-names>Gabriel N.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Crown</surname><given-names>John P.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Pedrazzoli</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Bregni</surname><given-names>Marco</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Demirer</surname><given-names>Taner</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><aff id="aff1">Donald A. Berry, Naoto T. Ueno, Marcella M. Johnson, Xiudong Lei, Jean Caputo, Gabriel N. Hortobagyi, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Sjoerd Rodenhuis, the Netherlands Cancer Institute, Amsterdam, the Netherlands; William P. Peters, Regional Consultants in Hematology Oncology, Amelia Island, FL; Robert C. Leonard, Charing Cross Hospital, London, United Kingdom; William E. Barlow, Southwest Oncology Group Statistical Center, Seattle, WA; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, New York, NY; Jonas Bergh, Karolinska Institutet and University Hospital, Stockholm, Sweden; Ulrike A. Nitz, West German Study Group, Düsseldorf, Germany; Alessandro M. Gianni, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Russel L. Basser, Royal Melbourne Hospital, Parkville, Victoria, Australia; Axel R. Zander, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; R. Charles Coombes, Imperial College London, London, United Kingdom; Henri Roché, Institut Claudius Regaud, Toulouse, France; Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan; Elisabeth G.E. de Vries, University Medical Center Groningen, Groningen, the Netherlands; John P. Crown, St Vincent's University Hospital, Dublin, Ireland; Paolo Pedrazzoli, Gruppo Italiano Trapianto di Midollo Oncologia, Policlinico San Matteo, Pavia, Italy; Marco Bregni, San Raffaele Scientific Institute, Milan, Italy; Taner Demirer, Ankara University, Ankara, Turkey.</aff></contrib-group><author-notes><corresp id="cor1">Corresponding author: Donald A. Berry, PhD, Professor, Division of Quantitative Sciences, Department of Biostatistics, The University of Texas MD Anderson Cancer Center, PO Box 301402, Unit 1409, Houston, TX 77230-1402; e-mail: <email>dberry@mdanderson.org</email>.</corresp></author-notes><pub-date pub-type="ppub"><day>20</day><month>8</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>18</day><month>7</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>20</day><month>8</month><year>2012</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>29</volume><issue>24</issue><fpage>3214</fpage><lpage>3223</lpage><history><date date-type="received"><day>7</day><month>10</month><year>2010</year></date><date date-type="accepted"><day>25</day><month>5</month><year>2011</year></date></history><permissions><copyright-statement>© 2011 by American Society of Clinical Oncology</copyright-statement><copyright-year>2011</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zlj02411003214.pdf"></self-uri><abstract><sec><title>Purpose</title><p>Adjuvant high-dose chemotherapy (HDC) with autologous hematopoietic stem-cell transplantation (AHST) for high-risk primary breast cancer has not been shown to prolong survival. Individual trials have had limited power to show overall benefit or benefits within subsets.</p></sec><sec><title>Methods</title><p>We assembled individual patient data from 15 randomized trials that compared HDC versus control therapy without stem-cell support. Prospectively defined primary end points were relapse-free survival (RFS) and overall survival (OS). We compared the effect of HDC versus control by using log-rank tests and proportional hazards regression, and we adjusted for clinically relevant covariates. Subset analyses were by age, number of positive lymph nodes, tumor size, histology, hormone receptor (HmR) status, and human epidermal growth factor receptor 2 (HER2) status.</p></sec><sec><title>Results</title><p>Of 6,210 total patients (n = 3,118, HDC; n = 3,092 control), the median age was 46 years; 69% were premenopausal, 29% were postmenopausal, and 2% were unknown menopausal status; 49.5% were HmR positive; 33.5% were HmR negative, and 17% were unknown HmR status. The median follow-up was 6 years. After analysis was adjusted for covariates, HDC was found to prolong relapse-free survival (RFS; hazard ratio [HR], 0.87; 95% CI, 0.81 to 0.93; <italic>P</italic> < .001) but not overall survival (OS; HR, 0.94; 95% CI, 0.87 to 1.02; <italic>P</italic> = .13). For OS, no covariates had statistically significant interactions with treatment effect, and no subsets evinced a significant effect of HDC. Younger patients had a significantly better RFS on HDC than did older patients.</p></sec><sec><title>Conclusion</title><p>Adjuvant HDC with AHST prolonged RFS in high-risk primary breast cancer compared with control, but this did not translate into a significant OS benefit. Whether HDC benefits patients in the context of targeted therapies is unknown.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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