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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study</title><author><name sortKey="Pappo, Alberto S" sort="Pappo, Alberto S" uniqKey="Pappo A" first="Alberto S." last="Pappo">Alberto S. Pappo</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Patel, Shreyaskumar R" sort="Patel, Shreyaskumar R" uniqKey="Patel S" first="Shreyaskumar R." last="Patel">Shreyaskumar R. Patel</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Crowley, John" sort="Crowley, John" uniqKey="Crowley J" first="John" last="Crowley">John Crowley</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Reinke, Denise K" sort="Reinke, Denise K" uniqKey="Reinke D" first="Denise K." last="Reinke">Denise K. Reinke</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Kuenkele, Klaus Peter" sort="Kuenkele, Klaus Peter" uniqKey="Kuenkele K" first="Klaus-Peter" last="Kuenkele">Klaus-Peter Kuenkele</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Chawla, Sant P" sort="Chawla, Sant P" uniqKey="Chawla S" first="Sant P." last="Chawla">Sant P. Chawla</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Toner, Guy C" sort="Toner, Guy C" uniqKey="Toner G" first="Guy C." last="Toner">Guy C. Toner</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Maki, Robert G" sort="Maki, Robert G" uniqKey="Maki R" first="Robert G." last="Maki">Robert G. Maki</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Meyers, Paul A" sort="Meyers, Paul A" uniqKey="Meyers P" first="Paul A." last="Meyers">Paul A. Meyers</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Chugh, Rashmi" sort="Chugh, Rashmi" uniqKey="Chugh R" first="Rashmi" last="Chugh">Rashmi Chugh</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Ganjoo, Kristen N" sort="Ganjoo, Kristen N" uniqKey="Ganjoo K" first="Kristen N." last="Ganjoo">Kristen N. Ganjoo</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Schuetze, Scott M" sort="Schuetze, Scott M" uniqKey="Schuetze S" first="Scott M." last="Schuetze">Scott M. Schuetze</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Juergens, Heribert" sort="Juergens, Heribert" uniqKey="Juergens H" first="Heribert" last="Juergens">Heribert Juergens</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Leahy, Michael G" sort="Leahy, Michael G" uniqKey="Leahy M" first="Michael G." last="Leahy">Michael G. Leahy</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Geoerger, Birgit" sort="Geoerger, Birgit" uniqKey="Geoerger B" first="Birgit" last="Geoerger">Birgit Geoerger</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Benjamin, Robert S" sort="Benjamin, Robert S" uniqKey="Benjamin R" first="Robert S." last="Benjamin">Robert S. Benjamin</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Helman, Lee J" sort="Helman, Lee J" uniqKey="Helman L" first="Lee J." last="Helman">Lee J. Helman</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Baker, Laurence H" sort="Baker, Laurence H" uniqKey="Baker L" first="Laurence H." last="Baker">Laurence H. Baker</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22025149</idno><idno type="pmc">3236654</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236654</idno><idno type="RBID">PMC:3236654</idno><idno type="doi">10.1200/JCO.2010.34.0000</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001940</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001940</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study</title><author><name sortKey="Pappo, Alberto S" sort="Pappo, Alberto S" uniqKey="Pappo A" first="Alberto S." last="Pappo">Alberto S. Pappo</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Patel, Shreyaskumar R" sort="Patel, Shreyaskumar R" uniqKey="Patel S" first="Shreyaskumar R." last="Patel">Shreyaskumar R. Patel</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Crowley, John" sort="Crowley, John" uniqKey="Crowley J" first="John" last="Crowley">John Crowley</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Reinke, Denise K" sort="Reinke, Denise K" uniqKey="Reinke D" first="Denise K." last="Reinke">Denise K. Reinke</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Kuenkele, Klaus Peter" sort="Kuenkele, Klaus Peter" uniqKey="Kuenkele K" first="Klaus-Peter" last="Kuenkele">Klaus-Peter Kuenkele</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Chawla, Sant P" sort="Chawla, Sant P" uniqKey="Chawla S" first="Sant P." last="Chawla">Sant P. Chawla</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Toner, Guy C" sort="Toner, Guy C" uniqKey="Toner G" first="Guy C." last="Toner">Guy C. Toner</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Maki, Robert G" sort="Maki, Robert G" uniqKey="Maki R" first="Robert G." last="Maki">Robert G. Maki</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Meyers, Paul A" sort="Meyers, Paul A" uniqKey="Meyers P" first="Paul A." last="Meyers">Paul A. Meyers</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Chugh, Rashmi" sort="Chugh, Rashmi" uniqKey="Chugh R" first="Rashmi" last="Chugh">Rashmi Chugh</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Ganjoo, Kristen N" sort="Ganjoo, Kristen N" uniqKey="Ganjoo K" first="Kristen N." last="Ganjoo">Kristen N. Ganjoo</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Schuetze, Scott M" sort="Schuetze, Scott M" uniqKey="Schuetze S" first="Scott M." last="Schuetze">Scott M. Schuetze</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Juergens, Heribert" sort="Juergens, Heribert" uniqKey="Juergens H" first="Heribert" last="Juergens">Heribert Juergens</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Leahy, Michael G" sort="Leahy, Michael G" uniqKey="Leahy M" first="Michael G." last="Leahy">Michael G. Leahy</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Geoerger, Birgit" sort="Geoerger, Birgit" uniqKey="Geoerger B" first="Birgit" last="Geoerger">Birgit Geoerger</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Benjamin, Robert S" sort="Benjamin, Robert S" uniqKey="Benjamin R" first="Robert S." last="Benjamin">Robert S. Benjamin</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Helman, Lee J" sort="Helman, Lee J" uniqKey="Helman L" first="Lee J." last="Helman">Lee J. Helman</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author><author><name sortKey="Baker, Laurence H" sort="Baker, Laurence H" uniqKey="Baker L" first="Laurence H." last="Baker">Laurence H. Baker</name><affiliation><nlm:aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Clinical Oncology</title><idno type="ISSN">0732-183X</idno><idno type="eISSN">1527-7755</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>The type 1 insulin-like growth factor 1 receptor (IGF-1R) has been implicated in the pathogenesis of the Ewing sarcoma family of tumors (ESFT). We conducted a multicenter phase II study of the fully human IGF-1R monoclonal antibody R1507 in patients with recurrent or refractory ESFT.</p></sec><sec><title>Patients and Methods</title><p>Patients ≥ 2 years of age with refractory or recurrent ESFT received R1507 at doses of 9 mg/kg intravenously one a week or 27 mg/kg intravenously every three weeks. Response was measured by using WHO criteria. Tumor imaging was performed every 6 weeks for 24 weeks and then every 12 weeks.</p></sec><sec><title>Results</title><p>From December 2007 through April 2010, 115 eligible patients from 31 different institutions were enrolled. The median age was 25 years (range, 8 to 78 years). The location of the primary tumor was bone in 57% of patients and extraskeletal in 43% of patients. A total of 109 patients were treated with R1507 9 mg/kg/wk, and six patients were treated with 27 mg/kg/3 wk. The overall complete response/partial response rate was 10% (95% CI, 4.9% to 16.5%). The median duration of response was 29 weeks (range, 12 to 94 weeks), and the median overall survival was 7.6 months (95% CI, 6 to 9.7 months). Ten of 11 responses were observed in patients who presented with primary bone tumors (<italic>P</italic> = .016). The most common adverse events of grades 3 to 4 were pain (15%), anemia (8%), thrombocytopenia (7%), and asthenia (5%).</p></sec><sec><title>Conclusion</title><p>R1507 was a well-tolerated agent that had meaningful and durable benefit in a subgroup of patients with ESFT. The identification of markers that are predictive of a benefit is necessary to fully capitalize on this approach.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Oncol</journal-id><journal-id journal-id-type="hwp">jco</journal-id><journal-id journal-id-type="pmc">jco</journal-id><journal-id journal-id-type="publisher-id">JCO</journal-id><journal-title-group><journal-title>Journal of Clinical Oncology</journal-title></journal-title-group><issn pub-type="ppub">0732-183X</issn><issn pub-type="epub">1527-7755</issn><publisher><publisher-name>American Society of Clinical Oncology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22025149</article-id><article-id pub-id-type="pmc">3236654</article-id><article-id pub-id-type="publisher-id">40000</article-id><article-id pub-id-type="doi">10.1200/JCO.2010.34.0000</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>Pedi5</subject><subject>Sarc1</subject></subj-group><subj-group subj-group-type="heading"><subject>Original Reports</subject><subj-group><subject>Sarcomas</subject></subj-group></subj-group></article-categories><title-group><article-title>R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study</article-title><alt-title alt-title-type="short">SARC Study of IGF-1R Antibody in Ewing Sarcoma</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Pappo</surname><given-names>Alberto S.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Patel</surname><given-names>Shreyaskumar R.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Crowley</surname><given-names>John</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Reinke</surname><given-names>Denise K.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Kuenkele</surname><given-names>Klaus-Peter</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Chawla</surname><given-names>Sant P.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Toner</surname><given-names>Guy C.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Maki</surname><given-names>Robert G.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Meyers</surname><given-names>Paul A.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Chugh</surname><given-names>Rashmi</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Ganjoo</surname><given-names>Kristen N.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Schuetze</surname><given-names>Scott M.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Juergens</surname><given-names>Heribert</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Leahy</surname><given-names>Michael G.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Geoerger</surname><given-names>Birgit</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Benjamin</surname><given-names>Robert S.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Helman</surname><given-names>Lee J.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Baker</surname><given-names>Laurence H.</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><aff id="aff1">Alberto S. Pappo, St Jude Children's Research Hospital, Memphis, TN; Shreyaskumar R. Patel and Robert S. Benjamin, MD Anderson Cancer Center, Houston, TX; John Crowley, Cancer Research and Biostatistics, Seattle, WA; Denise K. Reinke, Sarcoma Alliance for Research through Collaboration; Rashmi Chugh, Scott M. Schuetze, and Laurence H. Baker, University of Michigan, Ann Arbor, MI; Klaus-Peter Kuenkele, Roche, Penzberg; Heribert Juergens, University Children's Hospital, Muenster, Germany; Sant P. Chawla, Sarcoma Oncology, Santa Monica; Kristen N. Ganjoo, Stanford University, Stanford, CA; Guy C. Toner, Peter MacCallum Cancer Centre, Victoria, Australia; Robert G. Maki and Paul A. Meyers, Memorial Sloan-Kettering Cancer Center, New York, NY; Michael G. Leahy, Christie Hospital National Health Service Foundation Trust, Manchester, United Kingdom; Birgit Geoerger, Institut Gustave Roussy, Villejuif, France; and Lee J. Helman, National Cancer Institute, Bethesda, MD.</aff></contrib-group><author-notes><corresp id="cor1">Corresponding author: Laurence H. Baker, DO, 24 Frank Lloyd Wright Dr, Room Lobby A 3400, Ann Arbor, MI 48105-5731; e-mail: <email>bakerl@umich.edu</email>.</corresp></author-notes><pub-date pub-type="ppub"><day>1</day><month>12</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>24</day><month>10</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>12</month><year>2012</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>29</volume><issue>34</issue><fpage>4541</fpage><lpage>4547</lpage><history><date date-type="received"><day>3</day><month>12</month><year>2010</year></date><date date-type="accepted"><day>26</day><month>8</month><year>2011</year></date></history><permissions><copyright-statement>© 2011 by American Society of Clinical Oncology</copyright-statement><copyright-year>2011</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zlj03411004541.pdf"></self-uri><abstract><sec><title>Purpose</title><p>The type 1 insulin-like growth factor 1 receptor (IGF-1R) has been implicated in the pathogenesis of the Ewing sarcoma family of tumors (ESFT). We conducted a multicenter phase II study of the fully human IGF-1R monoclonal antibody R1507 in patients with recurrent or refractory ESFT.</p></sec><sec><title>Patients and Methods</title><p>Patients ≥ 2 years of age with refractory or recurrent ESFT received R1507 at doses of 9 mg/kg intravenously one a week or 27 mg/kg intravenously every three weeks. Response was measured by using WHO criteria. Tumor imaging was performed every 6 weeks for 24 weeks and then every 12 weeks.</p></sec><sec><title>Results</title><p>From December 2007 through April 2010, 115 eligible patients from 31 different institutions were enrolled. The median age was 25 years (range, 8 to 78 years). The location of the primary tumor was bone in 57% of patients and extraskeletal in 43% of patients. A total of 109 patients were treated with R1507 9 mg/kg/wk, and six patients were treated with 27 mg/kg/3 wk. The overall complete response/partial response rate was 10% (95% CI, 4.9% to 16.5%). The median duration of response was 29 weeks (range, 12 to 94 weeks), and the median overall survival was 7.6 months (95% CI, 6 to 9.7 months). Ten of 11 responses were observed in patients who presented with primary bone tumors (<italic>P</italic> = .016). The most common adverse events of grades 3 to 4 were pain (15%), anemia (8%), thrombocytopenia (7%), and asthenia (5%).</p></sec><sec><title>Conclusion</title><p>R1507 was a well-tolerated agent that had meaningful and durable benefit in a subgroup of patients with ESFT. The identification of markers that are predictive of a benefit is necessary to fully capitalize on this approach.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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