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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages</title><author><name sortKey="Labadie, Karine" sort="Labadie, Karine" uniqKey="Labadie K" first="Karine" last="Labadie">Karine Labadie</name><affiliation><nlm:aff id="JCI40104">CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.</nlm:aff></affiliation><affiliation><nlm:aff id="JCI40104">UMR-E1, Paris-Sud 11, Orsay, France.</nlm:aff></affiliation></author><author><name sortKey="Larcher, Thibaut" sort="Larcher, Thibaut" uniqKey="Larcher T" first="Thibaut" last="Larcher">Thibaut Larcher</name><affiliation><nlm:aff id="JCI40104">INRA, UMR 703, Ecole Nationale Vétérinaire, Nantes, France.</nlm:aff></affiliation></author><author><name sortKey="Joubert, Christophe" sort="Joubert, Christophe" uniqKey="Joubert C" first="Christophe" last="Joubert">Christophe Joubert</name><affiliation><nlm:aff id="JCI40104">CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.</nlm:aff></affiliation><affiliation><nlm:aff id="JCI40104">UMR-E1, Paris-Sud 11, Orsay, France.</nlm:aff></affiliation></author><author><name sortKey="Mannioui, Abdelkrim" sort="Mannioui, Abdelkrim" uniqKey="Mannioui A" first="Abdelkrim" last="Mannioui">Abdelkrim Mannioui</name><affiliation><nlm:aff id="JCI40104">CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.</nlm:aff></affiliation><affiliation><nlm:aff id="JCI40104">UMR-E1, Paris-Sud 11, Orsay, France.</nlm:aff></affiliation></author><author><name sortKey="Delache, Benoit" sort="Delache, Benoit" uniqKey="Delache B" first="Benoit" last="Delache">Benoit Delache</name><affiliation><nlm:aff id="JCI40104">CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.</nlm:aff></affiliation><affiliation><nlm:aff id="JCI40104">UMR-E1, Paris-Sud 11, Orsay, France.</nlm:aff></affiliation></author><author><name sortKey="Brochard, Patricia" sort="Brochard, Patricia" uniqKey="Brochard P" first="Patricia" last="Brochard">Patricia Brochard</name><affiliation><nlm:aff id="JCI40104">CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.</nlm:aff></affiliation><affiliation><nlm:aff id="JCI40104">UMR-E1, Paris-Sud 11, Orsay, France.</nlm:aff></affiliation></author><author><name sortKey="Guigand, Lydie" sort="Guigand, Lydie" uniqKey="Guigand L" first="Lydie" last="Guigand">Lydie Guigand</name><affiliation><nlm:aff id="JCI40104">INRA, UMR 703, Ecole Nationale Vétérinaire, Nantes, France.</nlm:aff></affiliation></author><author><name sortKey="Dubreil, Laurence" sort="Dubreil, Laurence" uniqKey="Dubreil L" first="Laurence" last="Dubreil">Laurence Dubreil</name><affiliation><nlm:aff id="JCI40104">INRA, UMR 703, Ecole Nationale Vétérinaire, Nantes, France.</nlm:aff></affiliation></author><author><name sortKey="Lebon, Pierre" sort="Lebon, Pierre" uniqKey="Lebon P" first="Pierre" last="Lebon">Pierre Lebon</name><affiliation><nlm:aff id="JCI40104">Université Paris V, Hôpital Cochin-St Vincent de Paul, Service de virologie, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Verrier, Bernard" sort="Verrier, Bernard" uniqKey="Verrier B" first="Bernard" last="Verrier">Bernard Verrier</name><affiliation><nlm:aff id="JCI40104">CNRS, UMR 5086, IBCP-IFR 128, Lyon, France.</nlm:aff></affiliation></author><author><name sortKey="De Lamballerie, Xavier" sort="De Lamballerie, Xavier" uniqKey="De Lamballerie X" first="Xavier" last="De Lamballerie">Xavier De Lamballerie</name><affiliation><nlm:aff id="JCI40104">Université de la Méditerranée, Unité des Virus Emergents, Marseille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="JCI40104">Institut de Recherche pour le Développement, Marseille, France.</nlm:aff></affiliation></author><author><name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name><affiliation><nlm:aff id="JCI40104">Australian Centre for International and Tropical Health, Queensland Institute of Medical Research, Brisbane, Australia.</nlm:aff></affiliation></author><author><name sortKey="Cherel, Yan" sort="Cherel, Yan" uniqKey="Cherel Y" first="Yan" last="Cherel">Yan Cherel</name><affiliation><nlm:aff id="JCI40104">INRA, UMR 703, Ecole Nationale Vétérinaire, Nantes, France.</nlm:aff></affiliation></author><author><name sortKey="Le Grand, Roger" sort="Le Grand, Roger" uniqKey="Le Grand R" first="Roger" last="Le Grand">Roger Le Grand</name><affiliation><nlm:aff id="JCI40104">CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.</nlm:aff></affiliation><affiliation><nlm:aff id="JCI40104">UMR-E1, Paris-Sud 11, Orsay, France.</nlm:aff></affiliation></author><author><name sortKey="Roques, Pierre" sort="Roques, Pierre" uniqKey="Roques P" first="Pierre" last="Roques">Pierre Roques</name><affiliation><nlm:aff id="JCI40104">CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.</nlm:aff></affiliation><affiliation><nlm:aff id="JCI40104">UMR-E1, Paris-Sud 11, Orsay, France.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20179353</idno><idno type="pmc">2827953</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827953</idno><idno type="RBID">PMC:2827953</idno><idno type="doi">10.1172/JCI40104</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">001931</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001931</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages</title><author><name sortKey="Labadie, Karine" sort="Labadie, Karine" uniqKey="Labadie K" first="Karine" last="Labadie">Karine Labadie</name><affiliation><nlm:aff id="JCI40104">CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.</nlm:aff></affiliation><affiliation><nlm:aff id="JCI40104">UMR-E1, Paris-Sud 11, Orsay, France.</nlm:aff></affiliation></author><author><name sortKey="Larcher, Thibaut" sort="Larcher, Thibaut" uniqKey="Larcher T" first="Thibaut" last="Larcher">Thibaut Larcher</name><affiliation><nlm:aff id="JCI40104">INRA, UMR 703, Ecole Nationale Vétérinaire, Nantes, France.</nlm:aff></affiliation></author><author><name sortKey="Joubert, Christophe" sort="Joubert, Christophe" uniqKey="Joubert C" first="Christophe" last="Joubert">Christophe Joubert</name><affiliation><nlm:aff id="JCI40104">CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.</nlm:aff></affiliation><affiliation><nlm:aff id="JCI40104">UMR-E1, Paris-Sud 11, Orsay, France.</nlm:aff></affiliation></author><author><name sortKey="Mannioui, Abdelkrim" sort="Mannioui, Abdelkrim" uniqKey="Mannioui A" first="Abdelkrim" last="Mannioui">Abdelkrim Mannioui</name><affiliation><nlm:aff id="JCI40104">CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.</nlm:aff></affiliation><affiliation><nlm:aff id="JCI40104">UMR-E1, Paris-Sud 11, Orsay, France.</nlm:aff></affiliation></author><author><name sortKey="Delache, Benoit" sort="Delache, Benoit" uniqKey="Delache B" first="Benoit" last="Delache">Benoit Delache</name><affiliation><nlm:aff id="JCI40104">CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.</nlm:aff></affiliation><affiliation><nlm:aff id="JCI40104">UMR-E1, Paris-Sud 11, Orsay, France.</nlm:aff></affiliation></author><author><name sortKey="Brochard, Patricia" sort="Brochard, Patricia" uniqKey="Brochard P" first="Patricia" last="Brochard">Patricia Brochard</name><affiliation><nlm:aff id="JCI40104">CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.</nlm:aff></affiliation><affiliation><nlm:aff id="JCI40104">UMR-E1, Paris-Sud 11, Orsay, France.</nlm:aff></affiliation></author><author><name sortKey="Guigand, Lydie" sort="Guigand, Lydie" uniqKey="Guigand L" first="Lydie" last="Guigand">Lydie Guigand</name><affiliation><nlm:aff id="JCI40104">INRA, UMR 703, Ecole Nationale Vétérinaire, Nantes, France.</nlm:aff></affiliation></author><author><name sortKey="Dubreil, Laurence" sort="Dubreil, Laurence" uniqKey="Dubreil L" first="Laurence" last="Dubreil">Laurence Dubreil</name><affiliation><nlm:aff id="JCI40104">INRA, UMR 703, Ecole Nationale Vétérinaire, Nantes, France.</nlm:aff></affiliation></author><author><name sortKey="Lebon, Pierre" sort="Lebon, Pierre" uniqKey="Lebon P" first="Pierre" last="Lebon">Pierre Lebon</name><affiliation><nlm:aff id="JCI40104">Université Paris V, Hôpital Cochin-St Vincent de Paul, Service de virologie, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Verrier, Bernard" sort="Verrier, Bernard" uniqKey="Verrier B" first="Bernard" last="Verrier">Bernard Verrier</name><affiliation><nlm:aff id="JCI40104">CNRS, UMR 5086, IBCP-IFR 128, Lyon, France.</nlm:aff></affiliation></author><author><name sortKey="De Lamballerie, Xavier" sort="De Lamballerie, Xavier" uniqKey="De Lamballerie X" first="Xavier" last="De Lamballerie">Xavier De Lamballerie</name><affiliation><nlm:aff id="JCI40104">Université de la Méditerranée, Unité des Virus Emergents, Marseille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="JCI40104">Institut de Recherche pour le Développement, Marseille, France.</nlm:aff></affiliation></author><author><name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name><affiliation><nlm:aff id="JCI40104">Australian Centre for International and Tropical Health, Queensland Institute of Medical Research, Brisbane, Australia.</nlm:aff></affiliation></author><author><name sortKey="Cherel, Yan" sort="Cherel, Yan" uniqKey="Cherel Y" first="Yan" last="Cherel">Yan Cherel</name><affiliation><nlm:aff id="JCI40104">INRA, UMR 703, Ecole Nationale Vétérinaire, Nantes, France.</nlm:aff></affiliation></author><author><name sortKey="Le Grand, Roger" sort="Le Grand, Roger" uniqKey="Le Grand R" first="Roger" last="Le Grand">Roger Le Grand</name><affiliation><nlm:aff id="JCI40104">CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.</nlm:aff></affiliation><affiliation><nlm:aff id="JCI40104">UMR-E1, Paris-Sud 11, Orsay, France.</nlm:aff></affiliation></author><author><name sortKey="Roques, Pierre" sort="Roques, Pierre" uniqKey="Roques P" first="Pierre" last="Roques">Pierre Roques</name><affiliation><nlm:aff id="JCI40104">CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.</nlm:aff></affiliation><affiliation><nlm:aff id="JCI40104">UMR-E1, Paris-Sud 11, Orsay, France.</nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Clinical Investigation</title><idno type="ISSN">0021-9738</idno><idno type="eISSN">1558-8238</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that induces in humans a disease characterized by fever, rash, and pain in muscles and joints. The recent emergence or reemergence of CHIKV in the Indian Ocean Islands and India has stressed the need to better understand the pathogenesis of this disease. Previous CHIKV disease models have used young or immunodeficient mice, but these do not recapitulate human disease patterns and are unsuitable for testing immune-based therapies. Herein, we describe what we believe to be a new model for CHIKV infection in adult, immunocompetent cynomolgus macaques. CHIKV infection in these animals recapitulated the viral, clinical, and pathological features observed in human disease. In the macaques, long-term CHIKV infection was observed in joints, muscles, lymphoid organs, and liver, which could explain the long-lasting CHIKV disease symptoms observed in humans. In addition, the study identified macrophages as the main cellular reservoirs during the late stages of CHIKV infection in vivo. This model of CHIKV physiopathology should allow the development of new therapeutic and/or prophylactic strategies.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Invest</journal-id><journal-id journal-id-type="publisher-id">J CLIN INVEST</journal-id><journal-title-group><journal-title>The Journal of Clinical Investigation</journal-title></journal-title-group><issn pub-type="ppub">0021-9738</issn><issn pub-type="epub">1558-8238</issn><publisher><publisher-name>American Society for Clinical Investigation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20179353</article-id><article-id pub-id-type="pmc">2827953</article-id><article-id pub-id-type="publisher-id">40104</article-id><article-id pub-id-type="doi">10.1172/JCI40104</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Labadie</surname><given-names>Karine</given-names></name><xref ref-type="aff" rid="JCI40104">1</xref><xref ref-type="aff" rid="JCI40104">2</xref></contrib><contrib contrib-type="author"><name><surname>Larcher</surname><given-names>Thibaut</given-names></name><xref ref-type="aff" rid="JCI40104">3</xref></contrib><contrib contrib-type="author"><name><surname>Joubert</surname><given-names>Christophe</given-names></name><xref ref-type="aff" rid="JCI40104">1</xref><xref ref-type="aff" rid="JCI40104">2</xref></contrib><contrib contrib-type="author"><name><surname>Mannioui</surname><given-names>Abdelkrim</given-names></name><xref ref-type="aff" rid="JCI40104">1</xref><xref ref-type="aff" rid="JCI40104">2</xref></contrib><contrib contrib-type="author"><name><surname>Delache</surname><given-names>Benoit</given-names></name><xref ref-type="aff" rid="JCI40104">1</xref><xref ref-type="aff" rid="JCI40104">2</xref></contrib><contrib contrib-type="author"><name><surname>Brochard</surname><given-names>Patricia</given-names></name><xref ref-type="aff" rid="JCI40104">1</xref><xref ref-type="aff" rid="JCI40104">2</xref></contrib><contrib contrib-type="author"><name><surname>Guigand</surname><given-names>Lydie</given-names></name><xref ref-type="aff" rid="JCI40104">3</xref></contrib><contrib contrib-type="author"><name><surname>Dubreil</surname><given-names>Laurence</given-names></name><xref ref-type="aff" rid="JCI40104">3</xref></contrib><contrib contrib-type="author"><name><surname>Lebon</surname><given-names>Pierre</given-names></name><xref ref-type="aff" rid="JCI40104">4</xref></contrib><contrib contrib-type="author"><name><surname>Verrier</surname><given-names>Bernard</given-names></name><xref ref-type="aff" rid="JCI40104">5</xref></contrib><contrib contrib-type="author"><name><surname>de Lamballerie</surname><given-names>Xavier</given-names></name><xref ref-type="aff" rid="JCI40104">6</xref><xref ref-type="aff" rid="JCI40104">7</xref></contrib><contrib contrib-type="author"><name><surname>Suhrbier</surname><given-names>Andreas</given-names></name><xref ref-type="aff" rid="JCI40104">8</xref></contrib><contrib contrib-type="author"><name><surname>Cherel</surname><given-names>Yan</given-names></name><xref ref-type="aff" rid="JCI40104">3</xref></contrib><contrib contrib-type="author"><name><surname>Le Grand</surname><given-names>Roger</given-names></name><xref ref-type="aff" rid="JCI40104">1</xref><xref ref-type="aff" rid="JCI40104">2</xref></contrib><contrib contrib-type="author"><name><surname>Roques</surname><given-names>Pierre</given-names></name><xref ref-type="aff" rid="JCI40104">1</xref><xref ref-type="aff" rid="JCI40104">2</xref></contrib></contrib-group><aff id="JCI40104"><label>1</label>CEA, Division of Immuno-Virology/Institute of Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.<label>2</label>UMR-E1, Paris-Sud 11, Orsay, France.<label>3</label>INRA, UMR 703, Ecole Nationale Vétérinaire, Nantes, France.<label>4</label>Université Paris V, Hôpital Cochin-St Vincent de Paul, Service de virologie, Paris, France.<label>5</label>CNRS, UMR 5086, IBCP-IFR 128, Lyon, France.<label>6</label>Université de la Méditerranée, Unité des Virus Emergents, Marseille, France.<label>7</label>Institut de Recherche pour le Développement, Marseille, France.<label>8</label>Australian Centre for International and Tropical Health, Queensland Institute of Medical Research, Brisbane, Australia.</aff><author-notes><corresp>Address correspondence to: Pierre Roques, Service d’immuno-virologie, Commissariat à l’Energie Atomique, DSV/iMETI, 18 route du Panorama, 92265, Fontenay-aux-Roses, Cedex, France. Phone: 33.1.46.54.91.67; Fax: 33.1.46.54.77.26; E-mail:
<email>pierre.roques@cea.fr</email>.
</corresp></author-notes><pub-date pub-type="epub"><day>22</day><month>2</month><year>2010</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>3</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>22</day><month>2</month><year>2010</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>120</volume><issue>3</issue><fpage>894</fpage><lpage>906</lpage><history><date date-type="received"><day>5</day><month>6</month><year>2009</year></date><date date-type="accepted"><day>6</day><month>1</month><year>2010</year></date></history><permissions><copyright-statement>Copyright © 2010, American Society for Clinical Investigation</copyright-statement></permissions><abstract><p>Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that induces in humans a disease characterized by fever, rash, and pain in muscles and joints. The recent emergence or reemergence of CHIKV in the Indian Ocean Islands and India has stressed the need to better understand the pathogenesis of this disease. Previous CHIKV disease models have used young or immunodeficient mice, but these do not recapitulate human disease patterns and are unsuitable for testing immune-based therapies. Herein, we describe what we believe to be a new model for CHIKV infection in adult, immunocompetent cynomolgus macaques. CHIKV infection in these animals recapitulated the viral, clinical, and pathological features observed in human disease. In the macaques, long-term CHIKV infection was observed in joints, muscles, lymphoid organs, and liver, which could explain the long-lasting CHIKV disease symptoms observed in humans. In addition, the study identified macrophages as the main cellular reservoirs during the late stages of CHIKV infection in vivo. This model of CHIKV physiopathology should allow the development of new therapeutic and/or prophylactic strategies.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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