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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients</title><author><name sortKey="Magalhaes, Isabelle" sort="Magalhaes, Isabelle" uniqKey="Magalhaes I" first="Isabelle" last="Magalhaes">Isabelle Magalhaes</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Pingris, Karine" sort="Pingris, Karine" uniqKey="Pingris K" first="Karine" last="Pingris">Karine Pingris</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Poitou, Christine" sort="Poitou, Christine" uniqKey="Poitou C" first="Christine" last="Poitou">Christine Poitou</name><affiliation><nlm:aff id="A4">Sorbonne Universités, Université Pierre et Marie Curie, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">INSERM U1166, Institut de Cardiometabolisme et Nutrition (ICAN), Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">ICAN, Nutrition Department, Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital de la Pitié–Salpêtrière, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Bessoles, Stephanie" sort="Bessoles, Stephanie" uniqKey="Bessoles S" first="Stéphanie" last="Bessoles">Stéphanie Bessoles</name><affiliation><nlm:aff id="A7">INSERM U932, Institut Curie, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Venteclef, Nicolas" sort="Venteclef, Nicolas" uniqKey="Venteclef N" first="Nicolas" last="Venteclef">Nicolas Venteclef</name><affiliation><nlm:aff id="A4">Sorbonne Universités, Université Pierre et Marie Curie, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">INSERM U1166, Institut de Cardiometabolisme et Nutrition (ICAN), Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Kiaf, Badr" sort="Kiaf, Badr" uniqKey="Kiaf B" first="Badr" last="Kiaf">Badr Kiaf</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Beaudoin, Lucie" sort="Beaudoin, Lucie" uniqKey="Beaudoin L" first="Lucie" last="Beaudoin">Lucie Beaudoin</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Da Silva, Jennifer" sort="Da Silva, Jennifer" uniqKey="Da Silva J" first="Jennifer" last="Da Silva">Jennifer Da Silva</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Allatif, Omran" sort="Allatif, Omran" uniqKey="Allatif O" first="Omran" last="Allatif">Omran Allatif</name><affiliation><nlm:aff id="A4">Sorbonne Universités, Université Pierre et Marie Curie, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">INSERM U1166, Institut de Cardiometabolisme et Nutrition (ICAN), Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">ICAN, Nutrition Department, Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital de la Pitié–Salpêtrière, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Rossjohn, Jamie" sort="Rossjohn, Jamie" uniqKey="Rossjohn J" first="Jamie" last="Rossjohn">Jamie Rossjohn</name><affiliation><nlm:aff id="A8">ARC, Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Institute of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.</nlm:aff></affiliation></author><author><name sortKey="Kjer Nielsen, Lars" sort="Kjer Nielsen, Lars" uniqKey="Kjer Nielsen L" first="Lars" last="Kjer-Nielsen">Lars Kjer-Nielsen</name><affiliation><nlm:aff id="A10">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.</nlm:aff></affiliation></author><author><name sortKey="Mccluskey, James" sort="Mccluskey, James" uniqKey="Mccluskey J" first="James" last="Mccluskey">James Mccluskey</name><affiliation><nlm:aff id="A10">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.</nlm:aff></affiliation></author><author><name sortKey="Ledoux, Severine" sort="Ledoux, Severine" uniqKey="Ledoux S" first="Séverine" last="Ledoux">Séverine Ledoux</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A11">AP-HP, Service des Explorations Fonctionnelles, Centre de référence de prise en charge de l’obésité, Louis Mourier Hospital, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Genser, Laurent" sort="Genser, Laurent" uniqKey="Genser L" first="Laurent" last="Genser">Laurent Genser</name><affiliation><nlm:aff id="A4">Sorbonne Universités, Université Pierre et Marie Curie, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">INSERM U1166, Institut de Cardiometabolisme et Nutrition (ICAN), Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">ICAN, Nutrition Department, Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital de la Pitié–Salpêtrière, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Torcivia, Adriana" sort="Torcivia, Adriana" uniqKey="Torcivia A" first="Adriana" last="Torcivia">Adriana Torcivia</name><affiliation><nlm:aff id="A12">AP-HP, Département de Chirurgie, Pitié–Salpêtrière Hospital, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Soudais, Claire" sort="Soudais, Claire" uniqKey="Soudais C" first="Claire" last="Soudais">Claire Soudais</name><affiliation><nlm:aff id="A7">INSERM U932, Institut Curie, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Lantz, Olivier" sort="Lantz, Olivier" uniqKey="Lantz O" first="Olivier" last="Lantz">Olivier Lantz</name><affiliation><nlm:aff id="A7">INSERM U932, Institut Curie, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Boitard, Christian" sort="Boitard, Christian" uniqKey="Boitard C" first="Christian" last="Boitard">Christian Boitard</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A13">AP-HP, Département de Diabétologie, Cochin Hospital, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Aron Wisnewsky, Judith" sort="Aron Wisnewsky, Judith" uniqKey="Aron Wisnewsky J" first="Judith" last="Aron-Wisnewsky">Judith Aron-Wisnewsky</name><affiliation><nlm:aff id="A4">Sorbonne Universités, Université Pierre et Marie Curie, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">INSERM U1166, Institut de Cardiometabolisme et Nutrition (ICAN), Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">ICAN, Nutrition Department, Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital de la Pitié–Salpêtrière, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Larger, Etienne" sort="Larger, Etienne" uniqKey="Larger E" first="Etienne" last="Larger">Etienne Larger</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A13">AP-HP, Département de Diabétologie, Cochin Hospital, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Clement, Karine" sort="Clement, Karine" uniqKey="Clement K" first="Karine" last="Clément">Karine Clément</name><affiliation><nlm:aff id="A4">Sorbonne Universités, Université Pierre et Marie Curie, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">INSERM U1166, Institut de Cardiometabolisme et Nutrition (ICAN), Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">ICAN, Nutrition Department, Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital de la Pitié–Salpêtrière, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Lehuen, Agnes" sort="Lehuen, Agnes" uniqKey="Lehuen A" first="Agnès" last="Lehuen">Agnès Lehuen</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A13">AP-HP, Département de Diabétologie, Cochin Hospital, Paris, France.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25751065</idno><idno type="pmc">4396481</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396481</idno><idno type="RBID">PMC:4396481</idno><idno type="doi">10.1172/JCI78941</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001929</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001929</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients</title><author><name sortKey="Magalhaes, Isabelle" sort="Magalhaes, Isabelle" uniqKey="Magalhaes I" first="Isabelle" last="Magalhaes">Isabelle Magalhaes</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Pingris, Karine" sort="Pingris, Karine" uniqKey="Pingris K" first="Karine" last="Pingris">Karine Pingris</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Poitou, Christine" sort="Poitou, Christine" uniqKey="Poitou C" first="Christine" last="Poitou">Christine Poitou</name><affiliation><nlm:aff id="A4">Sorbonne Universités, Université Pierre et Marie Curie, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">INSERM U1166, Institut de Cardiometabolisme et Nutrition (ICAN), Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">ICAN, Nutrition Department, Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital de la Pitié–Salpêtrière, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Bessoles, Stephanie" sort="Bessoles, Stephanie" uniqKey="Bessoles S" first="Stéphanie" last="Bessoles">Stéphanie Bessoles</name><affiliation><nlm:aff id="A7">INSERM U932, Institut Curie, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Venteclef, Nicolas" sort="Venteclef, Nicolas" uniqKey="Venteclef N" first="Nicolas" last="Venteclef">Nicolas Venteclef</name><affiliation><nlm:aff id="A4">Sorbonne Universités, Université Pierre et Marie Curie, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">INSERM U1166, Institut de Cardiometabolisme et Nutrition (ICAN), Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Kiaf, Badr" sort="Kiaf, Badr" uniqKey="Kiaf B" first="Badr" last="Kiaf">Badr Kiaf</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Beaudoin, Lucie" sort="Beaudoin, Lucie" uniqKey="Beaudoin L" first="Lucie" last="Beaudoin">Lucie Beaudoin</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Da Silva, Jennifer" sort="Da Silva, Jennifer" uniqKey="Da Silva J" first="Jennifer" last="Da Silva">Jennifer Da Silva</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Allatif, Omran" sort="Allatif, Omran" uniqKey="Allatif O" first="Omran" last="Allatif">Omran Allatif</name><affiliation><nlm:aff id="A4">Sorbonne Universités, Université Pierre et Marie Curie, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">INSERM U1166, Institut de Cardiometabolisme et Nutrition (ICAN), Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">ICAN, Nutrition Department, Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital de la Pitié–Salpêtrière, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Rossjohn, Jamie" sort="Rossjohn, Jamie" uniqKey="Rossjohn J" first="Jamie" last="Rossjohn">Jamie Rossjohn</name><affiliation><nlm:aff id="A8">ARC, Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Institute of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.</nlm:aff></affiliation></author><author><name sortKey="Kjer Nielsen, Lars" sort="Kjer Nielsen, Lars" uniqKey="Kjer Nielsen L" first="Lars" last="Kjer-Nielsen">Lars Kjer-Nielsen</name><affiliation><nlm:aff id="A10">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.</nlm:aff></affiliation></author><author><name sortKey="Mccluskey, James" sort="Mccluskey, James" uniqKey="Mccluskey J" first="James" last="Mccluskey">James Mccluskey</name><affiliation><nlm:aff id="A10">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.</nlm:aff></affiliation></author><author><name sortKey="Ledoux, Severine" sort="Ledoux, Severine" uniqKey="Ledoux S" first="Séverine" last="Ledoux">Séverine Ledoux</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A11">AP-HP, Service des Explorations Fonctionnelles, Centre de référence de prise en charge de l’obésité, Louis Mourier Hospital, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Genser, Laurent" sort="Genser, Laurent" uniqKey="Genser L" first="Laurent" last="Genser">Laurent Genser</name><affiliation><nlm:aff id="A4">Sorbonne Universités, Université Pierre et Marie Curie, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">INSERM U1166, Institut de Cardiometabolisme et Nutrition (ICAN), Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">ICAN, Nutrition Department, Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital de la Pitié–Salpêtrière, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Torcivia, Adriana" sort="Torcivia, Adriana" uniqKey="Torcivia A" first="Adriana" last="Torcivia">Adriana Torcivia</name><affiliation><nlm:aff id="A12">AP-HP, Département de Chirurgie, Pitié–Salpêtrière Hospital, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Soudais, Claire" sort="Soudais, Claire" uniqKey="Soudais C" first="Claire" last="Soudais">Claire Soudais</name><affiliation><nlm:aff id="A7">INSERM U932, Institut Curie, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Lantz, Olivier" sort="Lantz, Olivier" uniqKey="Lantz O" first="Olivier" last="Lantz">Olivier Lantz</name><affiliation><nlm:aff id="A7">INSERM U932, Institut Curie, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Boitard, Christian" sort="Boitard, Christian" uniqKey="Boitard C" first="Christian" last="Boitard">Christian Boitard</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A13">AP-HP, Département de Diabétologie, Cochin Hospital, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Aron Wisnewsky, Judith" sort="Aron Wisnewsky, Judith" uniqKey="Aron Wisnewsky J" first="Judith" last="Aron-Wisnewsky">Judith Aron-Wisnewsky</name><affiliation><nlm:aff id="A4">Sorbonne Universités, Université Pierre et Marie Curie, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">INSERM U1166, Institut de Cardiometabolisme et Nutrition (ICAN), Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">ICAN, Nutrition Department, Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital de la Pitié–Salpêtrière, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Larger, Etienne" sort="Larger, Etienne" uniqKey="Larger E" first="Etienne" last="Larger">Etienne Larger</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A13">AP-HP, Département de Diabétologie, Cochin Hospital, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Clement, Karine" sort="Clement, Karine" uniqKey="Clement K" first="Karine" last="Clément">Karine Clément</name><affiliation><nlm:aff id="A4">Sorbonne Universités, Université Pierre et Marie Curie, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">INSERM U1166, Institut de Cardiometabolisme et Nutrition (ICAN), Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">ICAN, Nutrition Department, Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital de la Pitié–Salpêtrière, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Lehuen, Agnes" sort="Lehuen, Agnes" uniqKey="Lehuen A" first="Agnès" last="Lehuen">Agnès Lehuen</name><affiliation><nlm:aff id="A1">INSERM U1016, Institut Cochin, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">CNRS, UMR8104, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A13">AP-HP, Département de Diabétologie, Cochin Hospital, Paris, France.</nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Clinical Investigation</title><idno type="ISSN">0021-9738</idno><idno type="eISSN">1558-8238</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Obesity and type 2 diabetes (T2D) are associated with low-grade inflammation, activation of immune cells, and alterations of the gut microbiota. Mucosal-associated invariant T (MAIT) cells, which are innate-like T cells that recognize bacterial ligands, are present in blood and enriched in mucosal and inflamed tissues. Here, we analyzed MAIT cells in the blood and adipose tissues of patients with T2D and/or severe obesity. We determined that circulating MAIT cell frequency was dramatically decreased in both patient groups, and this population was even undetectable in some obese patients. Moreover, in both patient groups, circulating MAIT cells displayed an activated phenotype that was associated with elevated Th1 and Th17 cytokine production. In obese patients, MAIT cells were more abundant in adipose tissue than in the blood and exhibited a striking IL-17 profile. Bariatric surgery in obese patients not only improved their metabolic parameters but also increased circulating MAIT cell frequency at 3 months after surgery. Similarly, cytokine production by blood MAIT cells was strongly decreased after surgery. This study reveals profound MAIT cell abnormalities in patients harboring metabolic disorders, suggesting their potential role in these pathologies.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Invest</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Invest</journal-id><journal-id journal-id-type="publisher-id">J CLIN INVEST</journal-id><journal-title-group><journal-title>The Journal of Clinical Investigation</journal-title></journal-title-group><issn pub-type="ppub">0021-9738</issn><issn pub-type="epub">1558-8238</issn><publisher><publisher-name>American Society for Clinical Investigation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25751065</article-id><article-id pub-id-type="pmc">4396481</article-id><article-id pub-id-type="publisher-id">78941</article-id><article-id pub-id-type="doi">10.1172/JCI78941</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Magalhaes</surname><given-names>Isabelle</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Pingris</surname><given-names>Karine</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Poitou</surname><given-names>Christine</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Bessoles</surname><given-names>Stéphanie</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Venteclef</surname><given-names>Nicolas</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Kiaf</surname><given-names>Badr</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Beaudoin</surname><given-names>Lucie</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Da Silva</surname><given-names>Jennifer</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Allatif</surname><given-names>Omran</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Rossjohn</surname><given-names>Jamie</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Kjer-Nielsen</surname><given-names>Lars</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>McCluskey</surname><given-names>James</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Ledoux</surname><given-names>Séverine</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Genser</surname><given-names>Laurent</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Torcivia</surname><given-names>Adriana</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Soudais</surname><given-names>Claire</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Lantz</surname><given-names>Olivier</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Boitard</surname><given-names>Christian</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Aron-Wisnewsky</surname><given-names>Judith</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Larger</surname><given-names>Etienne</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Clément</surname><given-names>Karine</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Lehuen</surname><given-names>Agnès</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A13">13</xref></contrib></contrib-group><aff id="A1"><label>1</label>INSERM U1016, Institut Cochin, Paris, France.</aff><aff id="A2"><label>2</label>CNRS, UMR8104, Paris, France.</aff><aff id="A3"><label>3</label>Laboratoire d’Excellence INFLAMEX, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</aff><aff id="A4"><label>4</label>Sorbonne Universités, Université Pierre et Marie Curie, Paris, France.</aff><aff id="A5"><label>5</label>INSERM U1166, Institut de Cardiometabolisme et Nutrition (ICAN), Paris, France.</aff><aff id="A6"><label>6</label>ICAN, Nutrition Department, Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital de la Pitié–Salpêtrière, Paris, France.</aff><aff id="A7"><label>7</label>INSERM U932, Institut Curie, Paris, France.</aff><aff id="A8"><label>8</label>ARC, Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.</aff><aff id="A9"><label>9</label>Institute of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.</aff><aff id="A10"><label>10</label>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.</aff><aff id="A11"><label>11</label>AP-HP, Service des Explorations Fonctionnelles, Centre de référence de prise en charge de l’obésité, Louis Mourier Hospital, Paris, France.</aff><aff id="A12"><label>12</label>AP-HP, Département de Chirurgie, Pitié–Salpêtrière Hospital, Paris, France.</aff><aff id="A13"><label>13</label>AP-HP, Département de Diabétologie, Cochin Hospital, Paris, France.</aff><author-notes><corresp>Address correspondence to: Agnès Lehuen, Institut Cochin, INSERM U1016, CNRS UMR8104, 123 Boulevard Port-Royal, 75014 Paris, France. Phone: 331.76.53.55.90; Fax: 331.46.34.64.54; E-mail: <email>agnes.lehuen@inserm.fr</email>.</corresp><fn><p><bold>Authorship note:</bold> Isabelle Magalhaes and Karine Pingris, as well as Karine Clément and Agnès Lehuen, contributed equally to this work.</p></fn></author-notes><pub-date pub-type="epub"><day>9</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>7</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 3 months and
0 days and was based on the
<volume>125</volume><issue>4</issue><fpage>1752</fpage><lpage>1762</lpage><history><date date-type="received"><day>29</day><month>12</month><year>2014</year></date><date date-type="accepted"><day>15</day><month>1</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015, American Society for Clinical Investigation</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>American Society for Clinical Investigation</copyright-holder></permissions><abstract><p>Obesity and type 2 diabetes (T2D) are associated with low-grade inflammation, activation of immune cells, and alterations of the gut microbiota. Mucosal-associated invariant T (MAIT) cells, which are innate-like T cells that recognize bacterial ligands, are present in blood and enriched in mucosal and inflamed tissues. Here, we analyzed MAIT cells in the blood and adipose tissues of patients with T2D and/or severe obesity. We determined that circulating MAIT cell frequency was dramatically decreased in both patient groups, and this population was even undetectable in some obese patients. Moreover, in both patient groups, circulating MAIT cells displayed an activated phenotype that was associated with elevated Th1 and Th17 cytokine production. In obese patients, MAIT cells were more abundant in adipose tissue than in the blood and exhibited a striking IL-17 profile. Bariatric surgery in obese patients not only improved their metabolic parameters but also increased circulating MAIT cell frequency at 3 months after surgery. Similarly, cytokine production by blood MAIT cells was strongly decreased after surgery. This study reveals profound MAIT cell abnormalities in patients harboring metabolic disorders, suggesting their potential role in these pathologies.</p></abstract><kwd-group kwd-group-type="specialties"><kwd>Endocrinology</kwd><kwd>Immunology</kwd><kwd>Metabolism</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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