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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Novel Nuclear Trafficking Module Regulates the Nucleocytoplasmic Localization of the Rabies Virus Interferon Antagonist, P Protein<xref ref-type="fn" rid="FN1">*</xref><xref ref-type="fn" rid="FN2"><sup><inline-graphic xlink:href="sbox.jpg"></inline-graphic></sup></xref></title><author><name sortKey="Oksayan, Sibil" sort="Oksayan, Sibil" uniqKey="Oksayan S" first="Sibil" last="Oksayan">Sibil Oksayan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff2">Nuclear Signaling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, 3800 Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Wiltzer, Linda" sort="Wiltzer, Linda" uniqKey="Wiltzer L" first="Linda" last="Wiltzer">Linda Wiltzer</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff2">Nuclear Signaling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, 3800 Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Rowe, Caitlin L" sort="Rowe, Caitlin L" uniqKey="Rowe C" first="Caitlin L." last="Rowe">Caitlin L. Rowe</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff2">Nuclear Signaling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, 3800 Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Blondel, Danielle" sort="Blondel, Danielle" uniqKey="Blondel D" first="Danielle" last="Blondel">Danielle Blondel</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Jans, David A" sort="Jans, David A" uniqKey="Jans D" first="David A." last="Jans">David A. Jans</name><affiliation><nlm:aff wicri:cut=" and" id="aff2">Nuclear Signaling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, 3800 Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Moseley, Gregory W" sort="Moseley, Gregory W" uniqKey="Moseley G" first="Gregory W." last="Moseley">Gregory W. Moseley</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22700958</idno><idno type="pmc">3431689</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431689</idno><idno type="RBID">PMC:3431689</idno><idno type="doi">10.1074/jbc.M112.374694</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001917</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001917</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Novel Nuclear Trafficking Module Regulates the Nucleocytoplasmic Localization of the Rabies Virus Interferon Antagonist, P Protein<xref ref-type="fn" rid="FN1">*</xref><xref ref-type="fn" rid="FN2"><sup><inline-graphic xlink:href="sbox.jpg"></inline-graphic></sup></xref></title><author><name sortKey="Oksayan, Sibil" sort="Oksayan, Sibil" uniqKey="Oksayan S" first="Sibil" last="Oksayan">Sibil Oksayan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff2">Nuclear Signaling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, 3800 Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Wiltzer, Linda" sort="Wiltzer, Linda" uniqKey="Wiltzer L" first="Linda" last="Wiltzer">Linda Wiltzer</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff2">Nuclear Signaling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, 3800 Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Rowe, Caitlin L" sort="Rowe, Caitlin L" uniqKey="Rowe C" first="Caitlin L." last="Rowe">Caitlin L. Rowe</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff2">Nuclear Signaling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, 3800 Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Blondel, Danielle" sort="Blondel, Danielle" uniqKey="Blondel D" first="Danielle" last="Blondel">Danielle Blondel</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Jans, David A" sort="Jans, David A" uniqKey="Jans D" first="David A." last="Jans">David A. Jans</name><affiliation><nlm:aff wicri:cut=" and" id="aff2">Nuclear Signaling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, 3800 Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Moseley, Gregory W" sort="Moseley, Gregory W" uniqKey="Moseley G" first="Gregory W." last="Moseley">Gregory W. Moseley</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Biological Chemistry</title><idno type="ISSN">0021-9258</idno><idno type="eISSN">1083-351X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> Rabies virus expresses five isoforms of P protein, which undergo nucleocytoplasmic trafficking important to roles as antagonists of interferon-mediated immunity.</p><p><bold>Results:</bold> P isoform trafficking is mediated by a novel module containing co-regulated overlapping nuclear localization and export signals.</p><p><bold>Conclusion:</bold> P isoform nuclear localization involves a novel trafficking module.</p><p><bold>Significance:</bold> A novel molecular switch regulating trafficking, important to a viral interferon antagonist, is identified.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Biol Chem</journal-id><journal-id journal-id-type="iso-abbrev">J. Biol. Chem</journal-id><journal-id journal-id-type="hwp">jbc</journal-id><journal-id journal-id-type="pmc">jbc</journal-id><journal-id journal-id-type="publisher-id">JBC</journal-id><journal-title-group><journal-title>The Journal of Biological Chemistry</journal-title></journal-title-group><issn pub-type="ppub">0021-9258</issn><issn pub-type="epub">1083-351X</issn><publisher><publisher-name>American Society for Biochemistry and Molecular Biology</publisher-name><publisher-loc>9650 Rockville Pike, Bethesda, MD 20814, U.S.A.</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22700958</article-id><article-id pub-id-type="pmc">3431689</article-id><article-id pub-id-type="publisher-id">M112.374694</article-id><article-id pub-id-type="doi">10.1074/jbc.M112.374694</article-id><article-categories><subj-group subj-group-type="heading"><subject>Cell Biology</subject></subj-group></article-categories><title-group><article-title>A Novel Nuclear Trafficking Module Regulates the Nucleocytoplasmic Localization of the Rabies Virus Interferon Antagonist, P Protein<xref ref-type="fn" rid="FN1">*</xref><xref ref-type="fn" rid="FN2"><sup><inline-graphic xlink:href="sbox.jpg"></inline-graphic></sup></xref></article-title><alt-title alt-title-type="short">Nuclear Localization of Rabies Virus Phosphoprotein</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Oksayan</surname><given-names>Sibil</given-names></name><xref ref-type="aff" rid="aff1"><sup>‡</sup></xref><xref ref-type="aff" rid="aff2"><sup>§</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wiltzer</surname><given-names>Linda</given-names></name><xref ref-type="aff" rid="aff1"><sup>‡</sup></xref><xref ref-type="aff" rid="aff2"><sup>§</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rowe</surname><given-names>Caitlin L.</given-names></name><xref ref-type="aff" rid="aff1"><sup>‡</sup></xref><xref ref-type="aff" rid="aff2"><sup>§</sup></xref></contrib><contrib contrib-type="author"><name><surname>Blondel</surname><given-names>Danielle</given-names></name><xref ref-type="aff" rid="aff3"><sup>¶</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jans</surname><given-names>David A.</given-names></name><xref ref-type="aff" rid="aff2"><sup>§</sup></xref></contrib><contrib contrib-type="author"><name><surname>Moseley</surname><given-names>Gregory W.</given-names></name><xref ref-type="aff" rid="aff1"><sup>‡</sup></xref><xref ref-type="corresp" rid="cor1"><sup>1</sup></xref></contrib><aff id="aff1">From the<label>‡</label>Viral Immune Evasion and Pathogenicity Laboratory and</aff><aff id="aff2"><label>§</label>Nuclear Signaling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, 3800 Victoria, Australia and</aff><aff id="aff3">the<label>¶</label>Laboratoire de Virologie Moléculaire et Structurale, Centre de Recherche de Gif, CNRS 91198 Gif-sur-Yvette, France</aff></contrib-group><author-notes><corresp id="cor1"><label>1</label> To whom correspondence should be addressed. Tel.: <phone>61-3-9902-9354</phone>; Fax: <fax>61-3-9902-9500</fax>; E-mail: <email>greg.moseley@monash.edu</email>.</corresp></author-notes><pub-date pub-type="ppub"><day>10</day><month>8</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>14</day><month>6</month><year>2012</year></pub-date><volume>287</volume><issue>33</issue><fpage>28112</fpage><lpage>28121</lpage><history><date date-type="received"><day>15</day><month>5</month><year>2012</year></date><date date-type="rev-recd"><day>13</day><month>6</month><year>2012</year></date></history><permissions><copyright-statement>© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zbc03312028112.pdf"></self-uri><abstract abstract-type="teaser"><p><bold>Background:</bold> Rabies virus expresses five isoforms of P protein, which undergo nucleocytoplasmic trafficking important to roles as antagonists of interferon-mediated immunity.</p><p><bold>Results:</bold> P isoform trafficking is mediated by a novel module containing co-regulated overlapping nuclear localization and export signals.</p><p><bold>Conclusion:</bold> P isoform nuclear localization involves a novel trafficking module.</p><p><bold>Significance:</bold> A novel molecular switch regulating trafficking, important to a viral interferon antagonist, is identified.</p></abstract><abstract><p>Regulated nucleocytoplasmic transport of proteins is central to cellular function and dysfunction during processes such as viral infection. Active protein trafficking into and out of the nucleus is dependent on the presence within cargo proteins of intrinsic specific modular signals for nuclear import (nuclear localization signals, NLSs) and export (nuclear export signals, NESs). Rabies virus (RabV) phospho (P) protein, which is largely responsible for antagonising the host anti-viral response, is expressed as five isoforms (P1–P5). The subcellular trafficking of these isoforms is thought to depend on a balance between the activities of a dominant N-terminal NES (N-NES) and a distinct C-terminal NLS (C-NLS). Specifically, the N-NES-containing isoforms P1 and P2 are cytoplasmic, whereas the shorter P3–P5 isoforms, which lack the N-NES, are believed to be nuclear through the activity of the C-NLS. Here, we show for the first time that RabV P contains an additional strong NLS in the N-terminal region (N-NLS), which, intriguingly, overlaps with the N-NES. This arrangement represents a novel nuclear trafficking module where the N-NLS is inactive in P1 but becomes activated in P3, concomitant with truncation of the N-NES, to become the principal targeting signal conferring nuclear accumulation. Understanding this unique switch arrangement of overlapping, co-regulated NES/NLS sequences is vital to delineating the critical role of RabV P protein in viral infection.</p></abstract><kwd-group><kwd>Intracellular Trafficking</kwd><kwd>Nuclear Pore</kwd><kwd>Nuclear Translocation</kwd><kwd>Nuclear Transport</kwd><kwd>Viral Protein</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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