Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Common Variants in Mendelian Kidney Disease Genes and Their Association with Renal Function</title><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation><nlm:aff id="aff1">Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Fuchsberger, Christian" sort="Fuchsberger, Christian" uniqKey="Fuchsberger C" first="Christian" last="Fuchsberger">Christian Fuchsberger</name><affiliation><nlm:aff id="aff2">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan;</nlm:aff></affiliation></author><author><name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name><affiliation><nlm:aff id="aff3">Renal Division, Freiburg University Clinic, Freiburg, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="O Eaghdha, Conall M" sort="O Eaghdha, Conall M" uniqKey="O Eaghdha C" first="Conall M." last="O Eaghdha">Conall M. O Eaghdha</name><affiliation><nlm:aff id="aff5">National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts;</nlm:aff></affiliation><affiliation><nlm:aff id="aff6">Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Pattaro, Cristian" sort="Pattaro, Cristian" uniqKey="Pattaro C" first="Cristian" last="Pattaro">Cristian Pattaro</name><affiliation><nlm:aff id="aff7">Centre for Biomedicine, European Academy of Bozen/Bolzano, Bolzano, Italy;</nlm:aff></affiliation></author><author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name><affiliation><nlm:aff id="aff8">Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota;</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="aff9">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts;</nlm:aff></affiliation><affiliation><nlm:aff id="aff10">Harvard Medical School, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="aff11">Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Endlich, Karlhans" sort="Endlich, Karlhans" uniqKey="Endlich K" first="Karlhans" last="Endlich">Karlhans Endlich</name><affiliation><nlm:aff id="aff12">Institute of Anatomy and Cell Biology, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Olden, Matthias" sort="Olden, Matthias" uniqKey="Olden M" first="Matthias" last="Olden">Matthias Olden</name><affiliation><nlm:aff id="aff13">Division of Nephrology, Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany;</nlm:aff></affiliation></author><author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name><affiliation><nlm:aff id="aff15">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts;</nlm:aff></affiliation><affiliation><nlm:aff id="aff16">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Tin, Adrienne" sort="Tin, Adrienne" uniqKey="Tin A" first="Adrienne" last="Tin">Adrienne Tin</name><affiliation><nlm:aff id="aff4">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Kim, Young J" sort="Kim, Young J" uniqKey="Kim Y" first="Young J." last="Kim">Young J. Kim</name><affiliation><nlm:aff id="aff17">Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff18">Genomics Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea;</nlm:aff></affiliation></author><author><name sortKey="Taliun, Daniel" sort="Taliun, Daniel" uniqKey="Taliun D" first="Daniel" last="Taliun">Daniel Taliun</name><affiliation><nlm:aff id="aff7">Centre for Biomedicine, European Academy of Bozen/Bolzano, Bolzano, Italy;</nlm:aff></affiliation></author><author><name sortKey="Li, Man" sort="Li, Man" uniqKey="Li M" first="Man" last="Li">Man Li</name><affiliation><nlm:aff id="aff4">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Feitosa, Mary" sort="Feitosa, Mary" uniqKey="Feitosa M" first="Mary" last="Feitosa">Mary Feitosa</name><affiliation><nlm:aff id="aff19">Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri;</nlm:aff></affiliation></author><author><name sortKey="Gorski, Mathias" sort="Gorski, Mathias" uniqKey="Gorski M" first="Mathias" last="Gorski">Mathias Gorski</name><affiliation><nlm:aff id="aff13">Division of Nephrology, Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff20">Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany;</nlm:aff></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation><nlm:aff id="aff16">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Hundertmark, Claudia" sort="Hundertmark, Claudia" uniqKey="Hundertmark C" first="Claudia" last="Hundertmark">Claudia Hundertmark</name><affiliation><nlm:aff id="aff3">Renal Division, Freiburg University Clinic, Freiburg, Germany;</nlm:aff></affiliation></author><author><name sortKey="Foster, Meredith C" sort="Foster, Meredith C" uniqKey="Foster M" first="Meredith C." last="Foster">Meredith C. Foster</name><affiliation><nlm:aff id="aff5">National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Glazer, Nicole" sort="Glazer, Nicole" uniqKey="Glazer N" first="Nicole" last="Glazer">Nicole Glazer</name><affiliation><nlm:aff id="aff21">Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name><affiliation><nlm:aff id="aff22">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands;</nlm:aff></affiliation><affiliation><nlm:aff id="aff23">Centre for Medical Systems Biology, Rotterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Rao, Madhumathi" sort="Rao, Madhumathi" uniqKey="Rao M" first="Madhumathi" last="Rao">Madhumathi Rao</name><affiliation><nlm:aff id="aff24">Division of Nephrology, Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name><affiliation><nlm:aff id="aff25">Research Institute, Icelandic Heart Association, Kopavogur, Iceland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff26">University of Iceland, Reykjavik, Iceland;</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Jeffrey R" sort="O Onnell, Jeffrey R" uniqKey="O Onnell J" first="Jeffrey R." last="O Onnell">Jeffrey R. O Onnell</name><affiliation><nlm:aff id="aff17">Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name><affiliation><nlm:aff id="aff27">Departments of Epidemiology and Biostatistics and Forensic Molecular Biology, Erasmus Medical Center, Rotterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:aff id="aff28">Clinical Research Branch, National Institute of Aging, Baltimore Maryland;</nlm:aff></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation><nlm:aff id="aff29">University of Washington, Seattle, Washington;</nlm:aff></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation><nlm:aff id="aff5">National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Atkinson, Elizabeth J" sort="Atkinson, Elizabeth J" uniqKey="Atkinson E" first="Elizabeth J." last="Atkinson">Elizabeth J. Atkinson</name><affiliation><nlm:aff id="aff8">Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota;</nlm:aff></affiliation></author><author><name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name><affiliation><nlm:aff id="aff30">Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina;</nlm:aff></affiliation></author><author><name sortKey="Cornelis, Marilyn C" sort="Cornelis, Marilyn C" uniqKey="Cornelis M" first="Marilyn C." last="Cornelis">Marilyn C. Cornelis</name><affiliation><nlm:aff id="aff31">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="aff32">Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="aff33">Department of Medicine, University of Leipzig, Leipzig, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff34">Adiposity Diseases Integrated Research and Treatment Center, University of Leipzig, Leipzig, Germany;</nlm:aff></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation><nlm:aff id="aff35">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Couraki, Vincent" sort="Couraki, Vincent" uniqKey="Couraki V" first="Vincent" last="Couraki">Vincent Couraki</name><affiliation><nlm:aff id="aff36">INSERM UMR744, Institut Pasteur, Lille, France;</nlm:aff></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation><nlm:aff id="aff37">Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff38">Centre for Information-Based Medicine, Hunter Medical Research Institute, Newcastle, Australia;</nlm:aff></affiliation></author><author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name><affiliation><nlm:aff id="aff39">Adriano-Buzzati Traverso-CNR Institute of Genetics and Biophysics, Naples, Italy;</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name><affiliation><nlm:aff id="aff40">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff41">Swiss Institute of Bioinformatics, Lausanne, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="aff42">Fimlab Laboratories, Department of Clinical Chemistry, School of Medicine, University of Tampere, Tampere, Finland;</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="aff43">Estonian Genome Center, University of Tartu, Tartu, Estonia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff44">Institute of Molecular and Cell Biology, Estonian Biocentre, University of Tartu, Tartu, Estonia;</nlm:aff></affiliation></author><author><name sortKey="Deshmukh, Harshal" sort="Deshmukh, Harshal" uniqKey="Deshmukh H" first="Harshal" last="Deshmukh">Harshal Deshmukh</name><affiliation><nlm:aff id="aff45">Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, University of Dundee, Ninewells Hospital, Dundee, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name><affiliation><nlm:aff id="aff46">IRCCS Burlo Garofolo Institute for Maternal and Child Health, University of Trieste, Trieste, Italy;</nlm:aff></affiliation></author><author><name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y." last="Chu">Audrey Y. Chu</name><affiliation><nlm:aff id="aff9">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name><affiliation><nlm:aff id="aff47">CNR Institute of Population Genetics, Sassari, Italy;</nlm:aff></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation><nlm:aff id="aff48">Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name><affiliation><nlm:aff id="aff49">Swiss Tropical and Public Health Institute, Basel, Switzerland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff50">University of Basel, Basel, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Kollerits, Barbara" sort="Kollerits, Barbara" uniqKey="Kollerits B" first="Barbara" last="Kollerits">Barbara Kollerits</name><affiliation><nlm:aff id="aff51">Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria;</nlm:aff></affiliation></author><author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><affiliation><nlm:aff id="aff52">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy;</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="aff53">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="aff53">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation><nlm:aff id="aff25">Research Institute, Icelandic Heart Association, Kopavogur, Iceland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff26">University of Iceland, Reykjavik, Iceland;</nlm:aff></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:aff id="aff25">Research Institute, Icelandic Heart Association, Kopavogur, Iceland;</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation><nlm:aff id="aff17">Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="aff54">Human Genetics Center, University of Texas Health Science Center, Houston, Texas;</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation><nlm:aff id="aff55">Austrian Stroke Prevention Study, Department of Neurology, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria;</nlm:aff></affiliation></author><author><name sortKey="Hofer, Edith" sort="Hofer, Edith" uniqKey="Hofer E" first="Edith" last="Hofer">Edith Hofer</name><affiliation><nlm:aff id="aff56">Austrian Stroke Prevention Study, Clinical Division of Neurogeriatrics, Department of Neurology, University Clinic of Neurology, Medical University of Graz, Graz, Austria;</nlm:aff></affiliation></author><author><name sortKey="Hu, Frank" sort="Hu, Frank" uniqKey="Hu F" first="Frank" last="Hu">Frank Hu</name><affiliation><nlm:aff id="aff31">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Demirkan, Ayse" sort="Demirkan, Ayse" uniqKey="Demirkan A" first="Ayse" last="Demirkan">Ayse Demirkan</name><affiliation><nlm:aff id="aff22">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation><nlm:aff id="aff22">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands;</nlm:aff></affiliation><affiliation><nlm:aff id="aff57">Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Turner, Stephen T" sort="Turner, Stephen T" uniqKey="Turner S" first="Stephen T." last="Turner">Stephen T. Turner</name><affiliation><nlm:aff id="aff58">Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota;</nlm:aff></affiliation></author><author><name sortKey="Ding, Jingzhong" sort="Ding, Jingzhong" uniqKey="Ding J" first="Jingzhong" last="Ding">Jingzhong Ding</name><affiliation><nlm:aff id="aff59">Division of Geriatrics, Department of Internal Medicine, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina;</nlm:aff></affiliation></author><author><name sortKey="Andrews, Jeanette S" sort="Andrews, Jeanette S" uniqKey="Andrews J" first="Jeanette S." last="Andrews">Jeanette S. Andrews</name><affiliation><nlm:aff id="aff60">Department of Biostatistical Sciences, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina;</nlm:aff></affiliation></author><author><name sortKey="Freedman, Barry I" sort="Freedman, Barry I" uniqKey="Freedman B" first="Barry I." last="Freedman">Barry I. Freedman</name><affiliation><nlm:aff id="aff61">Division of Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina;</nlm:aff></affiliation></author><author><name sortKey="Giulianini, Franco" sort="Giulianini, Franco" uniqKey="Giulianini F" first="Franco" last="Giulianini">Franco Giulianini</name><affiliation><nlm:aff id="aff9">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation><nlm:aff id="aff62">Department of Internal Medicine II, Ulm University Clinic, University of Ulm, Ulm, Germany;</nlm:aff></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:aff id="aff63">Hanover Unified Biobank, Hanover Medical School, Hanover, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff64">Research Unit of Molecular Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany;</nlm:aff></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation><nlm:aff id="aff65">Institute of Epidemiology I and II, German Research Center for Environmental Health, Neuherberg, Germany;</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H.-Erich" last="Wichmann">H.-Erich Wichmann</name><affiliation><nlm:aff id="aff65">Institute of Epidemiology I and II, German Research Center for Environmental Health, Neuherberg, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff66">Institute for Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-University, Munich, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff67">Grosshadern Clinic, Neuherberg, Germany;</nlm:aff></affiliation></author><author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name><affiliation><nlm:aff id="aff68">Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation><nlm:aff id="aff69">Croatian Centre for Global Health, University of Split Medical School, Split, Croatia;</nlm:aff></affiliation></author><author><name sortKey="Boban, Mladen" sort="Boban, Mladen" uniqKey="Boban M" first="Mladen" last="Boban">Mladen Boban</name><affiliation><nlm:aff id="aff69">Croatian Centre for Global Health, University of Split Medical School, Split, Croatia;</nlm:aff></affiliation></author><author><name sortKey="Minelli, Cosetta" sort="Minelli, Cosetta" uniqKey="Minelli C" first="Cosetta" last="Minelli">Cosetta Minelli</name><affiliation><nlm:aff id="aff7">Centre for Biomedicine, European Academy of Bozen/Bolzano, Bolzano, Italy;</nlm:aff></affiliation></author><author><name sortKey="Wheeler, Heather E" sort="Wheeler, Heather E" uniqKey="Wheeler H" first="Heather E." last="Wheeler">Heather E. Wheeler</name><affiliation><nlm:aff id="aff70">Department of Genetics, Stanford University, Stanford, California;</nlm:aff></affiliation><affiliation><nlm:aff id="aff71">Department of Medicine, University of Chicago, Chicago, Illinois;</nlm:aff></affiliation></author><author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><affiliation><nlm:aff id="aff32">Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Zaboli, Ghazal" sort="Zaboli, Ghazal" uniqKey="Zaboli G" first="Ghazal" last="Zaboli">Ghazal Zaboli</name><affiliation><nlm:aff id="aff32">Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="aff68">Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="aff72">Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="aff68">Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name><affiliation><nlm:aff id="aff73">Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany;</nlm:aff></affiliation></author><author><name sortKey="Nothlings, Ute" sort="Nothlings, Ute" uniqKey="Nothlings U" first="Ute" last="Nöthlings">Ute Nöthlings</name><affiliation><nlm:aff id="aff74">PopGen Biobank, Schleswig-Holstein University Hospital, Kiel, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff75">Institute for Epidemiology, University of Kiel, Kiel, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff76">Department of Nutrition and Food Sciences, University of Bonn, Bonn, Germany;</nlm:aff></affiliation></author><author><name sortKey="Jacobs, Gunnar" sort="Jacobs, Gunnar" uniqKey="Jacobs G" first="Gunnar" last="Jacobs">Gunnar Jacobs</name><affiliation><nlm:aff id="aff74">PopGen Biobank, Schleswig-Holstein University Hospital, Kiel, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff75">Institute for Epidemiology, University of Kiel, Kiel, Germany;</nlm:aff></affiliation></author><author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name><affiliation><nlm:aff id="aff77">Clinic for Prosthodontic Dentistry, Gerostomatology, and Material Science, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name><affiliation><nlm:aff id="aff11">Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation><nlm:aff id="aff11">Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Kroemer, Heyo K" sort="Kroemer, Heyo K" uniqKey="Kroemer H" first="Heyo K." last="Kroemer">Heyo K. Kroemer</name><affiliation><nlm:aff id="aff78">Institute of Pharmacology, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation><nlm:aff id="aff79">Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Stracke, Sylvia" sort="Stracke, Sylvia" uniqKey="Stracke S" first="Sylvia" last="Stracke">Sylvia Stracke</name><affiliation><nlm:aff id="aff80">Clinic for Internal Medicine A, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:aff id="aff11">Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:aff id="aff81">Institute for Community Medicine, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name><affiliation><nlm:aff id="aff33">Department of Medicine, University of Leipzig, Leipzig, Germany;</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="aff33">Department of Medicine, University of Leipzig, Leipzig, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff34">Adiposity Diseases Integrated Research and Treatment Center, University of Leipzig, Leipzig, Germany;</nlm:aff></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation><nlm:aff id="aff43">Estonian Genome Center, University of Tartu, Tartu, Estonia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff82">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="aff35">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="aff83">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="aff83">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S." last="Aulchenko">Yurii S. Aulchenko</name><affiliation><nlm:aff id="aff35">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:aff id="aff69">Croatian Centre for Global Health, University of Split Medical School, Split, Croatia;</nlm:aff></affiliation></author><author><name sortKey="Hastie, Nick" sort="Hastie, Nick" uniqKey="Hastie N" first="Nick" last="Hastie">Nick Hastie</name><affiliation><nlm:aff id="aff72">Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="aff72">Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation><nlm:aff id="aff84">INSERM U897, Institute of Public Health, Victor Segalen Bordeaux II University, Bordeaux, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff85">Victor Segalen Bordeaux II University, Bordeaux, France;</nlm:aff></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation><nlm:aff id="aff86">Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff87">Centre for Eye Research Australia, University of Melbourne, East Melbourne, Australia;</nlm:aff></affiliation></author><author><name sortKey="Stengel, Benedicte" sort="Stengel, Benedicte" uniqKey="Stengel B" first="Bénédicte" last="Stengel">Bénédicte Stengel</name><affiliation><nlm:aff id="aff88">INSERM UMRS 1018, Villejuif, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff89">UMRS 1018, University of Paris-Sud, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name><affiliation><nlm:aff id="aff39">Adriano-Buzzati Traverso-CNR Institute of Genetics and Biophysics, Naples, Italy;</nlm:aff></affiliation></author><author><name sortKey="Bergmann, Sven" sort="Bergmann, Sven" uniqKey="Bergmann S" first="Sven" last="Bergmann">Sven Bergmann</name><affiliation><nlm:aff id="aff41">Swiss Institute of Bioinformatics, Lausanne, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="aff90">Department of Clinical Physiology, Tampere University Hospital, School of Medicine, University of Tampere, Tampere, Finland;</nlm:aff></affiliation></author><author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name><affiliation><nlm:aff id="aff91">Department of Medicine, Turku University Hospital, University of Turku, Turku, Finland;</nlm:aff></affiliation></author><author><name sortKey="Nikopensius, Tiit" sort="Nikopensius, Tiit" uniqKey="Nikopensius T" first="Tiit" last="Nikopensius">Tiit Nikopensius</name><affiliation><nlm:aff id="aff44">Institute of Molecular and Cell Biology, Estonian Biocentre, University of Tartu, Tartu, Estonia;</nlm:aff></affiliation></author><author><name sortKey="Province, Michael" sort="Province, Michael" uniqKey="Province M" first="Michael" last="Province">Michael Province</name><affiliation><nlm:aff id="aff19">Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri;</nlm:aff></affiliation></author><author><name sortKey="Colhoun, Helen" sort="Colhoun, Helen" uniqKey="Colhoun H" first="Helen" last="Colhoun">Helen Colhoun</name><affiliation><nlm:aff id="aff45">Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, University of Dundee, Ninewells Hospital, Dundee, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Doney, Alex" sort="Doney, Alex" uniqKey="Doney A" first="Alex" last="Doney">Alex Doney</name><affiliation><nlm:aff id="aff92">National Health Service Tayside, Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, Dundee, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><affiliation><nlm:aff id="aff46">IRCCS Burlo Garofolo Institute for Maternal and Child Health, University of Trieste, Trieste, Italy;</nlm:aff></affiliation></author><author><name sortKey="Kr Mer, Bernhard K" sort="Kr Mer, Bernhard K" uniqKey="Kr Mer B" first="Bernhard K." last="Kr Mer">Bernhard K. Kr Mer</name><affiliation><nlm:aff id="aff93">Fifth Department of Medicine, Mannheim University Medical Centre, Mannheim, Germany;</nlm:aff></affiliation></author><author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name><affiliation><nlm:aff id="aff47">CNR Institute of Population Genetics, Sassari, Italy;</nlm:aff></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation><nlm:aff id="aff94">Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M." last="Buckley">Brendan M. Buckley</name><affiliation><nlm:aff id="aff95">Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland;</nlm:aff></affiliation></author><author><name sortKey="Adam, Martin" sort="Adam, Martin" uniqKey="Adam M" first="Martin" last="Adam">Martin Adam</name><affiliation><nlm:aff id="aff49">Swiss Tropical and Public Health Institute, Basel, Switzerland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff50">University of Basel, Basel, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Thun, Gian Andri" sort="Thun, Gian Andri" uniqKey="Thun G" first="Gian-Andri" last="Thun">Gian-Andri Thun</name><affiliation><nlm:aff id="aff49">Swiss Tropical and Public Health Institute, Basel, Switzerland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff50">University of Basel, Basel, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name><affiliation><nlm:aff id="aff96">First Department of Internal Medicine, Paracelsus Medical University, Salzburg, Austria;</nlm:aff></affiliation></author><author><name sortKey="Haun, Margot" sort="Haun, Margot" uniqKey="Haun M" first="Margot" last="Haun">Margot Haun</name><affiliation><nlm:aff id="aff51">Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria;</nlm:aff></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation><nlm:aff id="aff52">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy;</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation><nlm:aff id="aff86">Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia;</nlm:aff></affiliation></author><author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name><affiliation><nlm:aff id="aff39">Adriano-Buzzati Traverso-CNR Institute of Genetics and Biophysics, Naples, Italy;</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="aff97">Department of Internal Medicine, Vaudois University Hospital Center, University of Lausanne, Lausanne, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation><nlm:aff id="aff98">Research Centre of Applied and Preventive Cardiovascular Medicine, Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland;</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="aff43">Estonian Genome Center, University of Tartu, Tartu, Estonia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff44">Institute of Molecular and Cell Biology, Estonian Biocentre, University of Tartu, Tartu, Estonia;</nlm:aff></affiliation></author><author><name sortKey="Palmer, Colin" sort="Palmer, Colin" uniqKey="Palmer C" first="Colin" last="Palmer">Colin Palmer</name><affiliation><nlm:aff id="aff99">Biomedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><affiliation><nlm:aff id="aff46">IRCCS Burlo Garofolo Institute for Maternal and Child Health, University of Trieste, Trieste, Italy;</nlm:aff></affiliation></author><author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><affiliation><nlm:aff id="aff47">CNR Institute of Population Genetics, Sassari, Italy;</nlm:aff></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><affiliation><nlm:aff id="aff48">Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands;</nlm:aff></affiliation><affiliation><nlm:aff id="aff100">Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands;</nlm:aff></affiliation><affiliation><nlm:aff id="aff101">Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands;</nlm:aff></affiliation><affiliation><nlm:aff id="aff102">Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M." last="Probst-Hensch">Nicole M. Probst-Hensch</name><affiliation><nlm:aff id="aff49">Swiss Tropical and Public Health Institute, Basel, Switzerland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff50">University of Basel, Basel, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name><affiliation><nlm:aff id="aff51">Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria;</nlm:aff></affiliation></author><author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><affiliation><nlm:aff id="aff52">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy;</nlm:aff></affiliation><affiliation><nlm:aff id="aff103">CNR Institute of Molecular Genetics, Pavia, Italy;</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="aff25">Research Institute, Icelandic Heart Association, Kopavogur, Iceland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff26">University of Iceland, Reykjavik, Iceland;</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="aff17">Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff104">Geriatric Research and Education Clinical Center, Veterans Affairs Medical Center, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name><affiliation><nlm:aff id="aff4">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff105">Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation><nlm:aff id="aff56">Austrian Stroke Prevention Study, Clinical Division of Neurogeriatrics, Department of Neurology, University Clinic of Neurology, Medical University of Graz, Graz, Austria;</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="aff28">Clinical Research Branch, National Institute of Aging, Baltimore Maryland;</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="aff22">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands;</nlm:aff></affiliation><affiliation><nlm:aff id="aff23">Centre for Medical Systems Biology, Rotterdam, The Netherlands;</nlm:aff></affiliation><affiliation><nlm:aff id="aff106">Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, Leiden, the Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid" sort="Borecki, Ingrid" uniqKey="Borecki I" first="Ingrid" last="Borecki">Ingrid Borecki</name><affiliation><nlm:aff id="aff19">Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri;</nlm:aff></affiliation></author><author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name><affiliation><nlm:aff id="aff107">Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan;</nlm:aff></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation><nlm:aff id="aff30">Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina;</nlm:aff></affiliation></author><author><name sortKey="Curhan, Gary C" sort="Curhan, Gary C" uniqKey="Curhan G" first="Gary C." last="Curhan">Gary C. Curhan</name><affiliation><nlm:aff id="aff108">Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="aff68">Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="aff32">Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="aff68">Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name><affiliation><nlm:aff id="aff73">Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany;</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="aff7">Centre for Biomedicine, European Academy of Bozen/Bolzano, Bolzano, Italy;</nlm:aff></affiliation></author><author><name sortKey="Rettig, Rainer" sort="Rettig, Rainer" uniqKey="Rettig R" first="Rainer" last="Rettig">Rainer Rettig</name><affiliation><nlm:aff id="aff109">Institute of Physiology, University of Greifswald, Karlsburg, Germany;</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="aff82">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="aff110">Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline" sort="Witteman, Jacqueline" uniqKey="Witteman J" first="Jacqueline" last="Witteman">Jacqueline Witteman</name><affiliation><nlm:aff id="aff35">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="aff72">Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="aff9">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts;</nlm:aff></affiliation><affiliation><nlm:aff id="aff10">Harvard Medical School, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation><nlm:aff id="aff111">University Institute of Social and Preventive Medicine, Vaudois University Hospital Center, University of Lausanne, Lausanne, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name><affiliation><nlm:aff id="aff14">Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany;</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut="; and" id="aff112">Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name><affiliation><nlm:aff id="aff29">University of Washington, Seattle, Washington;</nlm:aff></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name><affiliation><nlm:aff id="aff5">National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts;</nlm:aff></affiliation><affiliation><nlm:aff id="aff113">Division of Endocrinology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Kao, W Linda" sort="Kao, W Linda" uniqKey="Kao W" first="W. Linda" last="Kao">W. Linda Kao</name><affiliation><nlm:aff id="aff4">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff105">Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Boger, Carsten A" sort="Boger, Carsten A" uniqKey="Boger C" first="Carsten A." last="Böger">Carsten A. Böger</name><affiliation><nlm:aff id="aff13">Division of Nephrology, Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24029420</idno><idno type="pmc">3839542</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839542</idno><idno type="RBID">PMC:3839542</idno><idno type="doi">10.1681/ASN.2012100983</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001904</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001904</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common Variants in Mendelian Kidney Disease Genes and Their Association with Renal Function</title><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation><nlm:aff id="aff1">Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Fuchsberger, Christian" sort="Fuchsberger, Christian" uniqKey="Fuchsberger C" first="Christian" last="Fuchsberger">Christian Fuchsberger</name><affiliation><nlm:aff id="aff2">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan;</nlm:aff></affiliation></author><author><name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name><affiliation><nlm:aff id="aff3">Renal Division, Freiburg University Clinic, Freiburg, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="O Eaghdha, Conall M" sort="O Eaghdha, Conall M" uniqKey="O Eaghdha C" first="Conall M." last="O Eaghdha">Conall M. O Eaghdha</name><affiliation><nlm:aff id="aff5">National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts;</nlm:aff></affiliation><affiliation><nlm:aff id="aff6">Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Pattaro, Cristian" sort="Pattaro, Cristian" uniqKey="Pattaro C" first="Cristian" last="Pattaro">Cristian Pattaro</name><affiliation><nlm:aff id="aff7">Centre for Biomedicine, European Academy of Bozen/Bolzano, Bolzano, Italy;</nlm:aff></affiliation></author><author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name><affiliation><nlm:aff id="aff8">Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota;</nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="aff9">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts;</nlm:aff></affiliation><affiliation><nlm:aff id="aff10">Harvard Medical School, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="aff11">Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Endlich, Karlhans" sort="Endlich, Karlhans" uniqKey="Endlich K" first="Karlhans" last="Endlich">Karlhans Endlich</name><affiliation><nlm:aff id="aff12">Institute of Anatomy and Cell Biology, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Olden, Matthias" sort="Olden, Matthias" uniqKey="Olden M" first="Matthias" last="Olden">Matthias Olden</name><affiliation><nlm:aff id="aff13">Division of Nephrology, Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany;</nlm:aff></affiliation></author><author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name><affiliation><nlm:aff id="aff15">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts;</nlm:aff></affiliation><affiliation><nlm:aff id="aff16">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Tin, Adrienne" sort="Tin, Adrienne" uniqKey="Tin A" first="Adrienne" last="Tin">Adrienne Tin</name><affiliation><nlm:aff id="aff4">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Kim, Young J" sort="Kim, Young J" uniqKey="Kim Y" first="Young J." last="Kim">Young J. Kim</name><affiliation><nlm:aff id="aff17">Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff18">Genomics Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea;</nlm:aff></affiliation></author><author><name sortKey="Taliun, Daniel" sort="Taliun, Daniel" uniqKey="Taliun D" first="Daniel" last="Taliun">Daniel Taliun</name><affiliation><nlm:aff id="aff7">Centre for Biomedicine, European Academy of Bozen/Bolzano, Bolzano, Italy;</nlm:aff></affiliation></author><author><name sortKey="Li, Man" sort="Li, Man" uniqKey="Li M" first="Man" last="Li">Man Li</name><affiliation><nlm:aff id="aff4">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Feitosa, Mary" sort="Feitosa, Mary" uniqKey="Feitosa M" first="Mary" last="Feitosa">Mary Feitosa</name><affiliation><nlm:aff id="aff19">Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri;</nlm:aff></affiliation></author><author><name sortKey="Gorski, Mathias" sort="Gorski, Mathias" uniqKey="Gorski M" first="Mathias" last="Gorski">Mathias Gorski</name><affiliation><nlm:aff id="aff13">Division of Nephrology, Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff20">Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany;</nlm:aff></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation><nlm:aff id="aff16">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Hundertmark, Claudia" sort="Hundertmark, Claudia" uniqKey="Hundertmark C" first="Claudia" last="Hundertmark">Claudia Hundertmark</name><affiliation><nlm:aff id="aff3">Renal Division, Freiburg University Clinic, Freiburg, Germany;</nlm:aff></affiliation></author><author><name sortKey="Foster, Meredith C" sort="Foster, Meredith C" uniqKey="Foster M" first="Meredith C." last="Foster">Meredith C. Foster</name><affiliation><nlm:aff id="aff5">National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Glazer, Nicole" sort="Glazer, Nicole" uniqKey="Glazer N" first="Nicole" last="Glazer">Nicole Glazer</name><affiliation><nlm:aff id="aff21">Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name><affiliation><nlm:aff id="aff22">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands;</nlm:aff></affiliation><affiliation><nlm:aff id="aff23">Centre for Medical Systems Biology, Rotterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Rao, Madhumathi" sort="Rao, Madhumathi" uniqKey="Rao M" first="Madhumathi" last="Rao">Madhumathi Rao</name><affiliation><nlm:aff id="aff24">Division of Nephrology, Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name><affiliation><nlm:aff id="aff25">Research Institute, Icelandic Heart Association, Kopavogur, Iceland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff26">University of Iceland, Reykjavik, Iceland;</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Jeffrey R" sort="O Onnell, Jeffrey R" uniqKey="O Onnell J" first="Jeffrey R." last="O Onnell">Jeffrey R. O Onnell</name><affiliation><nlm:aff id="aff17">Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name><affiliation><nlm:aff id="aff27">Departments of Epidemiology and Biostatistics and Forensic Molecular Biology, Erasmus Medical Center, Rotterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:aff id="aff28">Clinical Research Branch, National Institute of Aging, Baltimore Maryland;</nlm:aff></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation><nlm:aff id="aff29">University of Washington, Seattle, Washington;</nlm:aff></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation><nlm:aff id="aff5">National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Atkinson, Elizabeth J" sort="Atkinson, Elizabeth J" uniqKey="Atkinson E" first="Elizabeth J." last="Atkinson">Elizabeth J. Atkinson</name><affiliation><nlm:aff id="aff8">Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota;</nlm:aff></affiliation></author><author><name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name><affiliation><nlm:aff id="aff30">Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina;</nlm:aff></affiliation></author><author><name sortKey="Cornelis, Marilyn C" sort="Cornelis, Marilyn C" uniqKey="Cornelis M" first="Marilyn C." last="Cornelis">Marilyn C. Cornelis</name><affiliation><nlm:aff id="aff31">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="aff32">Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="aff33">Department of Medicine, University of Leipzig, Leipzig, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff34">Adiposity Diseases Integrated Research and Treatment Center, University of Leipzig, Leipzig, Germany;</nlm:aff></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation><nlm:aff id="aff35">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Couraki, Vincent" sort="Couraki, Vincent" uniqKey="Couraki V" first="Vincent" last="Couraki">Vincent Couraki</name><affiliation><nlm:aff id="aff36">INSERM UMR744, Institut Pasteur, Lille, France;</nlm:aff></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation><nlm:aff id="aff37">Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff38">Centre for Information-Based Medicine, Hunter Medical Research Institute, Newcastle, Australia;</nlm:aff></affiliation></author><author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name><affiliation><nlm:aff id="aff39">Adriano-Buzzati Traverso-CNR Institute of Genetics and Biophysics, Naples, Italy;</nlm:aff></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name><affiliation><nlm:aff id="aff40">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff41">Swiss Institute of Bioinformatics, Lausanne, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="aff42">Fimlab Laboratories, Department of Clinical Chemistry, School of Medicine, University of Tampere, Tampere, Finland;</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="aff43">Estonian Genome Center, University of Tartu, Tartu, Estonia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff44">Institute of Molecular and Cell Biology, Estonian Biocentre, University of Tartu, Tartu, Estonia;</nlm:aff></affiliation></author><author><name sortKey="Deshmukh, Harshal" sort="Deshmukh, Harshal" uniqKey="Deshmukh H" first="Harshal" last="Deshmukh">Harshal Deshmukh</name><affiliation><nlm:aff id="aff45">Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, University of Dundee, Ninewells Hospital, Dundee, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name><affiliation><nlm:aff id="aff46">IRCCS Burlo Garofolo Institute for Maternal and Child Health, University of Trieste, Trieste, Italy;</nlm:aff></affiliation></author><author><name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y." last="Chu">Audrey Y. Chu</name><affiliation><nlm:aff id="aff9">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name><affiliation><nlm:aff id="aff47">CNR Institute of Population Genetics, Sassari, Italy;</nlm:aff></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation><nlm:aff id="aff48">Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name><affiliation><nlm:aff id="aff49">Swiss Tropical and Public Health Institute, Basel, Switzerland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff50">University of Basel, Basel, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Kollerits, Barbara" sort="Kollerits, Barbara" uniqKey="Kollerits B" first="Barbara" last="Kollerits">Barbara Kollerits</name><affiliation><nlm:aff id="aff51">Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria;</nlm:aff></affiliation></author><author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><affiliation><nlm:aff id="aff52">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy;</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="aff53">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="aff53">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation><nlm:aff id="aff25">Research Institute, Icelandic Heart Association, Kopavogur, Iceland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff26">University of Iceland, Reykjavik, Iceland;</nlm:aff></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:aff id="aff25">Research Institute, Icelandic Heart Association, Kopavogur, Iceland;</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation><nlm:aff id="aff17">Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="aff54">Human Genetics Center, University of Texas Health Science Center, Houston, Texas;</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation><nlm:aff id="aff55">Austrian Stroke Prevention Study, Department of Neurology, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria;</nlm:aff></affiliation></author><author><name sortKey="Hofer, Edith" sort="Hofer, Edith" uniqKey="Hofer E" first="Edith" last="Hofer">Edith Hofer</name><affiliation><nlm:aff id="aff56">Austrian Stroke Prevention Study, Clinical Division of Neurogeriatrics, Department of Neurology, University Clinic of Neurology, Medical University of Graz, Graz, Austria;</nlm:aff></affiliation></author><author><name sortKey="Hu, Frank" sort="Hu, Frank" uniqKey="Hu F" first="Frank" last="Hu">Frank Hu</name><affiliation><nlm:aff id="aff31">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Demirkan, Ayse" sort="Demirkan, Ayse" uniqKey="Demirkan A" first="Ayse" last="Demirkan">Ayse Demirkan</name><affiliation><nlm:aff id="aff22">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation><nlm:aff id="aff22">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands;</nlm:aff></affiliation><affiliation><nlm:aff id="aff57">Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Turner, Stephen T" sort="Turner, Stephen T" uniqKey="Turner S" first="Stephen T." last="Turner">Stephen T. Turner</name><affiliation><nlm:aff id="aff58">Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota;</nlm:aff></affiliation></author><author><name sortKey="Ding, Jingzhong" sort="Ding, Jingzhong" uniqKey="Ding J" first="Jingzhong" last="Ding">Jingzhong Ding</name><affiliation><nlm:aff id="aff59">Division of Geriatrics, Department of Internal Medicine, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina;</nlm:aff></affiliation></author><author><name sortKey="Andrews, Jeanette S" sort="Andrews, Jeanette S" uniqKey="Andrews J" first="Jeanette S." last="Andrews">Jeanette S. Andrews</name><affiliation><nlm:aff id="aff60">Department of Biostatistical Sciences, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina;</nlm:aff></affiliation></author><author><name sortKey="Freedman, Barry I" sort="Freedman, Barry I" uniqKey="Freedman B" first="Barry I." last="Freedman">Barry I. Freedman</name><affiliation><nlm:aff id="aff61">Division of Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina;</nlm:aff></affiliation></author><author><name sortKey="Giulianini, Franco" sort="Giulianini, Franco" uniqKey="Giulianini F" first="Franco" last="Giulianini">Franco Giulianini</name><affiliation><nlm:aff id="aff9">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation><nlm:aff id="aff62">Department of Internal Medicine II, Ulm University Clinic, University of Ulm, Ulm, Germany;</nlm:aff></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:aff id="aff63">Hanover Unified Biobank, Hanover Medical School, Hanover, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff64">Research Unit of Molecular Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany;</nlm:aff></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation><nlm:aff id="aff65">Institute of Epidemiology I and II, German Research Center for Environmental Health, Neuherberg, Germany;</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H.-Erich" last="Wichmann">H.-Erich Wichmann</name><affiliation><nlm:aff id="aff65">Institute of Epidemiology I and II, German Research Center for Environmental Health, Neuherberg, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff66">Institute for Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-University, Munich, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff67">Grosshadern Clinic, Neuherberg, Germany;</nlm:aff></affiliation></author><author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name><affiliation><nlm:aff id="aff68">Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation><nlm:aff id="aff69">Croatian Centre for Global Health, University of Split Medical School, Split, Croatia;</nlm:aff></affiliation></author><author><name sortKey="Boban, Mladen" sort="Boban, Mladen" uniqKey="Boban M" first="Mladen" last="Boban">Mladen Boban</name><affiliation><nlm:aff id="aff69">Croatian Centre for Global Health, University of Split Medical School, Split, Croatia;</nlm:aff></affiliation></author><author><name sortKey="Minelli, Cosetta" sort="Minelli, Cosetta" uniqKey="Minelli C" first="Cosetta" last="Minelli">Cosetta Minelli</name><affiliation><nlm:aff id="aff7">Centre for Biomedicine, European Academy of Bozen/Bolzano, Bolzano, Italy;</nlm:aff></affiliation></author><author><name sortKey="Wheeler, Heather E" sort="Wheeler, Heather E" uniqKey="Wheeler H" first="Heather E." last="Wheeler">Heather E. Wheeler</name><affiliation><nlm:aff id="aff70">Department of Genetics, Stanford University, Stanford, California;</nlm:aff></affiliation><affiliation><nlm:aff id="aff71">Department of Medicine, University of Chicago, Chicago, Illinois;</nlm:aff></affiliation></author><author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><affiliation><nlm:aff id="aff32">Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Zaboli, Ghazal" sort="Zaboli, Ghazal" uniqKey="Zaboli G" first="Ghazal" last="Zaboli">Ghazal Zaboli</name><affiliation><nlm:aff id="aff32">Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="aff68">Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="aff72">Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="aff68">Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name><affiliation><nlm:aff id="aff73">Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany;</nlm:aff></affiliation></author><author><name sortKey="Nothlings, Ute" sort="Nothlings, Ute" uniqKey="Nothlings U" first="Ute" last="Nöthlings">Ute Nöthlings</name><affiliation><nlm:aff id="aff74">PopGen Biobank, Schleswig-Holstein University Hospital, Kiel, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff75">Institute for Epidemiology, University of Kiel, Kiel, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff76">Department of Nutrition and Food Sciences, University of Bonn, Bonn, Germany;</nlm:aff></affiliation></author><author><name sortKey="Jacobs, Gunnar" sort="Jacobs, Gunnar" uniqKey="Jacobs G" first="Gunnar" last="Jacobs">Gunnar Jacobs</name><affiliation><nlm:aff id="aff74">PopGen Biobank, Schleswig-Holstein University Hospital, Kiel, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff75">Institute for Epidemiology, University of Kiel, Kiel, Germany;</nlm:aff></affiliation></author><author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name><affiliation><nlm:aff id="aff77">Clinic for Prosthodontic Dentistry, Gerostomatology, and Material Science, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name><affiliation><nlm:aff id="aff11">Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation><nlm:aff id="aff11">Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Kroemer, Heyo K" sort="Kroemer, Heyo K" uniqKey="Kroemer H" first="Heyo K." last="Kroemer">Heyo K. Kroemer</name><affiliation><nlm:aff id="aff78">Institute of Pharmacology, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation><nlm:aff id="aff79">Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Stracke, Sylvia" sort="Stracke, Sylvia" uniqKey="Stracke S" first="Sylvia" last="Stracke">Sylvia Stracke</name><affiliation><nlm:aff id="aff80">Clinic for Internal Medicine A, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:aff id="aff11">Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:aff id="aff81">Institute for Community Medicine, University of Greifswald, Greifswald, Germany;</nlm:aff></affiliation></author><author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name><affiliation><nlm:aff id="aff33">Department of Medicine, University of Leipzig, Leipzig, Germany;</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="aff33">Department of Medicine, University of Leipzig, Leipzig, Germany;</nlm:aff></affiliation><affiliation><nlm:aff id="aff34">Adiposity Diseases Integrated Research and Treatment Center, University of Leipzig, Leipzig, Germany;</nlm:aff></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation><nlm:aff id="aff43">Estonian Genome Center, University of Tartu, Tartu, Estonia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff82">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="aff35">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="aff83">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="aff83">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S." last="Aulchenko">Yurii S. Aulchenko</name><affiliation><nlm:aff id="aff35">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:aff id="aff69">Croatian Centre for Global Health, University of Split Medical School, Split, Croatia;</nlm:aff></affiliation></author><author><name sortKey="Hastie, Nick" sort="Hastie, Nick" uniqKey="Hastie N" first="Nick" last="Hastie">Nick Hastie</name><affiliation><nlm:aff id="aff72">Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="aff72">Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation><nlm:aff id="aff84">INSERM U897, Institute of Public Health, Victor Segalen Bordeaux II University, Bordeaux, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff85">Victor Segalen Bordeaux II University, Bordeaux, France;</nlm:aff></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation><nlm:aff id="aff86">Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff87">Centre for Eye Research Australia, University of Melbourne, East Melbourne, Australia;</nlm:aff></affiliation></author><author><name sortKey="Stengel, Benedicte" sort="Stengel, Benedicte" uniqKey="Stengel B" first="Bénédicte" last="Stengel">Bénédicte Stengel</name><affiliation><nlm:aff id="aff88">INSERM UMRS 1018, Villejuif, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff89">UMRS 1018, University of Paris-Sud, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name><affiliation><nlm:aff id="aff39">Adriano-Buzzati Traverso-CNR Institute of Genetics and Biophysics, Naples, Italy;</nlm:aff></affiliation></author><author><name sortKey="Bergmann, Sven" sort="Bergmann, Sven" uniqKey="Bergmann S" first="Sven" last="Bergmann">Sven Bergmann</name><affiliation><nlm:aff id="aff41">Swiss Institute of Bioinformatics, Lausanne, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="aff90">Department of Clinical Physiology, Tampere University Hospital, School of Medicine, University of Tampere, Tampere, Finland;</nlm:aff></affiliation></author><author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name><affiliation><nlm:aff id="aff91">Department of Medicine, Turku University Hospital, University of Turku, Turku, Finland;</nlm:aff></affiliation></author><author><name sortKey="Nikopensius, Tiit" sort="Nikopensius, Tiit" uniqKey="Nikopensius T" first="Tiit" last="Nikopensius">Tiit Nikopensius</name><affiliation><nlm:aff id="aff44">Institute of Molecular and Cell Biology, Estonian Biocentre, University of Tartu, Tartu, Estonia;</nlm:aff></affiliation></author><author><name sortKey="Province, Michael" sort="Province, Michael" uniqKey="Province M" first="Michael" last="Province">Michael Province</name><affiliation><nlm:aff id="aff19">Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri;</nlm:aff></affiliation></author><author><name sortKey="Colhoun, Helen" sort="Colhoun, Helen" uniqKey="Colhoun H" first="Helen" last="Colhoun">Helen Colhoun</name><affiliation><nlm:aff id="aff45">Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, University of Dundee, Ninewells Hospital, Dundee, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Doney, Alex" sort="Doney, Alex" uniqKey="Doney A" first="Alex" last="Doney">Alex Doney</name><affiliation><nlm:aff id="aff92">National Health Service Tayside, Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, Dundee, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><affiliation><nlm:aff id="aff46">IRCCS Burlo Garofolo Institute for Maternal and Child Health, University of Trieste, Trieste, Italy;</nlm:aff></affiliation></author><author><name sortKey="Kr Mer, Bernhard K" sort="Kr Mer, Bernhard K" uniqKey="Kr Mer B" first="Bernhard K." last="Kr Mer">Bernhard K. Kr Mer</name><affiliation><nlm:aff id="aff93">Fifth Department of Medicine, Mannheim University Medical Centre, Mannheim, Germany;</nlm:aff></affiliation></author><author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name><affiliation><nlm:aff id="aff47">CNR Institute of Population Genetics, Sassari, Italy;</nlm:aff></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation><nlm:aff id="aff94">Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M." last="Buckley">Brendan M. Buckley</name><affiliation><nlm:aff id="aff95">Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland;</nlm:aff></affiliation></author><author><name sortKey="Adam, Martin" sort="Adam, Martin" uniqKey="Adam M" first="Martin" last="Adam">Martin Adam</name><affiliation><nlm:aff id="aff49">Swiss Tropical and Public Health Institute, Basel, Switzerland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff50">University of Basel, Basel, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Thun, Gian Andri" sort="Thun, Gian Andri" uniqKey="Thun G" first="Gian-Andri" last="Thun">Gian-Andri Thun</name><affiliation><nlm:aff id="aff49">Swiss Tropical and Public Health Institute, Basel, Switzerland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff50">University of Basel, Basel, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name><affiliation><nlm:aff id="aff96">First Department of Internal Medicine, Paracelsus Medical University, Salzburg, Austria;</nlm:aff></affiliation></author><author><name sortKey="Haun, Margot" sort="Haun, Margot" uniqKey="Haun M" first="Margot" last="Haun">Margot Haun</name><affiliation><nlm:aff id="aff51">Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria;</nlm:aff></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation><nlm:aff id="aff52">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy;</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation><nlm:aff id="aff86">Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia;</nlm:aff></affiliation></author><author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name><affiliation><nlm:aff id="aff39">Adriano-Buzzati Traverso-CNR Institute of Genetics and Biophysics, Naples, Italy;</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="aff97">Department of Internal Medicine, Vaudois University Hospital Center, University of Lausanne, Lausanne, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation><nlm:aff id="aff98">Research Centre of Applied and Preventive Cardiovascular Medicine, Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland;</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="aff43">Estonian Genome Center, University of Tartu, Tartu, Estonia;</nlm:aff></affiliation><affiliation><nlm:aff id="aff44">Institute of Molecular and Cell Biology, Estonian Biocentre, University of Tartu, Tartu, Estonia;</nlm:aff></affiliation></author><author><name sortKey="Palmer, Colin" sort="Palmer, Colin" uniqKey="Palmer C" first="Colin" last="Palmer">Colin Palmer</name><affiliation><nlm:aff id="aff99">Biomedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><affiliation><nlm:aff id="aff46">IRCCS Burlo Garofolo Institute for Maternal and Child Health, University of Trieste, Trieste, Italy;</nlm:aff></affiliation></author><author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><affiliation><nlm:aff id="aff47">CNR Institute of Population Genetics, Sassari, Italy;</nlm:aff></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><affiliation><nlm:aff id="aff48">Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands;</nlm:aff></affiliation><affiliation><nlm:aff id="aff100">Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands;</nlm:aff></affiliation><affiliation><nlm:aff id="aff101">Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands;</nlm:aff></affiliation><affiliation><nlm:aff id="aff102">Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M." last="Probst-Hensch">Nicole M. Probst-Hensch</name><affiliation><nlm:aff id="aff49">Swiss Tropical and Public Health Institute, Basel, Switzerland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff50">University of Basel, Basel, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name><affiliation><nlm:aff id="aff51">Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria;</nlm:aff></affiliation></author><author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><affiliation><nlm:aff id="aff52">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy;</nlm:aff></affiliation><affiliation><nlm:aff id="aff103">CNR Institute of Molecular Genetics, Pavia, Italy;</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="aff25">Research Institute, Icelandic Heart Association, Kopavogur, Iceland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff26">University of Iceland, Reykjavik, Iceland;</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="aff17">Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff104">Geriatric Research and Education Clinical Center, Veterans Affairs Medical Center, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name><affiliation><nlm:aff id="aff4">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff105">Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation><nlm:aff id="aff56">Austrian Stroke Prevention Study, Clinical Division of Neurogeriatrics, Department of Neurology, University Clinic of Neurology, Medical University of Graz, Graz, Austria;</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="aff28">Clinical Research Branch, National Institute of Aging, Baltimore Maryland;</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="aff22">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands;</nlm:aff></affiliation><affiliation><nlm:aff id="aff23">Centre for Medical Systems Biology, Rotterdam, The Netherlands;</nlm:aff></affiliation><affiliation><nlm:aff id="aff106">Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, Leiden, the Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid" sort="Borecki, Ingrid" uniqKey="Borecki I" first="Ingrid" last="Borecki">Ingrid Borecki</name><affiliation><nlm:aff id="aff19">Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri;</nlm:aff></affiliation></author><author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name><affiliation><nlm:aff id="aff107">Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan;</nlm:aff></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation><nlm:aff id="aff30">Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina;</nlm:aff></affiliation></author><author><name sortKey="Curhan, Gary C" sort="Curhan, Gary C" uniqKey="Curhan G" first="Gary C." last="Curhan">Gary C. Curhan</name><affiliation><nlm:aff id="aff108">Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="aff68">Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="aff32">Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="aff68">Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name><affiliation><nlm:aff id="aff73">Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany;</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="aff7">Centre for Biomedicine, European Academy of Bozen/Bolzano, Bolzano, Italy;</nlm:aff></affiliation></author><author><name sortKey="Rettig, Rainer" sort="Rettig, Rainer" uniqKey="Rettig R" first="Rainer" last="Rettig">Rainer Rettig</name><affiliation><nlm:aff id="aff109">Institute of Physiology, University of Greifswald, Karlsburg, Germany;</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="aff82">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="aff110">Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline" sort="Witteman, Jacqueline" uniqKey="Witteman J" first="Jacqueline" last="Witteman">Jacqueline Witteman</name><affiliation><nlm:aff id="aff35">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="aff72">Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="aff9">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts;</nlm:aff></affiliation><affiliation><nlm:aff id="aff10">Harvard Medical School, Boston, Massachusetts;</nlm:aff></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation><nlm:aff id="aff111">University Institute of Social and Preventive Medicine, Vaudois University Hospital Center, University of Lausanne, Lausanne, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name><affiliation><nlm:aff id="aff14">Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany;</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut="; and" id="aff112">Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name><affiliation><nlm:aff id="aff29">University of Washington, Seattle, Washington;</nlm:aff></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name><affiliation><nlm:aff id="aff5">National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts;</nlm:aff></affiliation><affiliation><nlm:aff id="aff113">Division of Endocrinology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Kao, W Linda" sort="Kao, W Linda" uniqKey="Kao W" first="W. Linda" last="Kao">W. Linda Kao</name><affiliation><nlm:aff id="aff4">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;</nlm:aff></affiliation><affiliation><nlm:aff id="aff105">Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland;</nlm:aff></affiliation></author><author><name sortKey="Boger, Carsten A" sort="Boger, Carsten A" uniqKey="Boger C" first="Carsten A." last="Böger">Carsten A. Böger</name><affiliation><nlm:aff id="aff13">Division of Nephrology, Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany;</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of the American Society of Nephrology : JASN</title><idno type="ISSN">1046-6673</idno><idno type="eISSN">1533-3450</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Many common genetic variants identified by genome-wide association studies for complex traits map to genes previously linked to rare inherited Mendelian disorders. A systematic analysis of common single-nucleotide polymorphisms (SNPs) in genes responsible for Mendelian diseases with kidney phenotypes has not been performed. We thus developed a comprehensive database of genes for Mendelian kidney conditions and evaluated the association between common genetic variants within these genes and kidney function in the general population. Using the Online Mendelian Inheritance in Man database, we identified 731 unique disease entries related to specific renal search terms and confirmed a kidney phenotype in 218 of these entries, corresponding to mutations in 258 genes. We interrogated common SNPs (minor allele frequency >5%) within these genes for association with the estimated GFR in 74,354 European-ancestry participants from the CKDGen Consortium. However, the top four candidate SNPs (rs6433115 at <italic>LRP2</italic>, rs1050700 at <italic>TSC1</italic>, rs249942 at <italic>PALB2</italic>, and rs9827843 at <italic>ROBO2</italic>) did not achieve significance in a stage 2 meta-analysis performed in 56,246 additional independent individuals, indicating that these common SNPs are not associated with estimated GFR. The effect of less common or rare variants in these genes on kidney function in the general population and disease-specific cohorts requires further research.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Am Soc Nephrol</journal-id><journal-id journal-id-type="iso-abbrev">J. Am. Soc. Nephrol</journal-id><journal-id journal-id-type="hwp">jnephrol</journal-id><journal-id journal-id-type="pmc">jnephrol</journal-id><journal-id journal-id-type="publisher-id">ASN</journal-id><journal-title-group><journal-title>Journal of the American Society of Nephrology : JASN</journal-title></journal-title-group><issn pub-type="ppub">1046-6673</issn><issn pub-type="epub">1533-3450</issn><publisher><publisher-name>American Society of Nephrology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24029420</article-id><article-id pub-id-type="pmc">3839542</article-id><article-id pub-id-type="publisher-id">2012100983</article-id><article-id pub-id-type="doi">10.1681/ASN.2012100983</article-id><article-categories><subj-group subj-group-type="heading"><subject>Clinical Research</subject></subj-group></article-categories><title-group><article-title>Common Variants in Mendelian Kidney Disease Genes and Their Association with Renal Function</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Parsa</surname><given-names>Afshin</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fuchsberger</surname><given-names>Christian</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Köttgen</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>O’Seaghdha</surname><given-names>Conall M.</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pattaro</surname><given-names>Cristian</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>de Andrade</surname><given-names>Mariza</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chasman</surname><given-names>Daniel I.</given-names></name><xref ref-type="aff" rid="aff9"><sup>9</sup></xref><xref ref-type="aff" rid="aff10"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Teumer</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="aff11"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Endlich</surname><given-names>Karlhans</given-names></name><xref ref-type="aff" rid="aff12"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Olden</surname><given-names>Matthias</given-names></name><xref ref-type="aff" rid="aff13"><sup>13</sup></xref><xref ref-type="aff" rid="aff14"><sup>14</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Ming-Huei</given-names></name><xref ref-type="aff" rid="aff15"><sup>15</sup></xref><xref ref-type="aff" rid="aff16"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tin</surname><given-names>Adrienne</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Young J.</given-names></name><xref ref-type="aff" rid="aff17"><sup>17</sup></xref><xref ref-type="aff" rid="aff18"><sup>18</sup></xref></contrib><contrib contrib-type="author"><name><surname>Taliun</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Man</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Feitosa</surname><given-names>Mary</given-names></name><xref ref-type="aff" rid="aff19"><sup>19</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gorski</surname><given-names>Mathias</given-names></name><xref ref-type="aff" rid="aff13"><sup>13</sup></xref><xref ref-type="aff" rid="aff20"><sup>20</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Qiong</given-names></name><xref ref-type="aff" rid="aff16"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hundertmark</surname><given-names>Claudia</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Foster</surname><given-names>Meredith C.</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Glazer</surname><given-names>Nicole</given-names></name><xref ref-type="aff" rid="aff21"><sup>21</sup></xref></contrib><contrib contrib-type="author"><name><surname>Isaacs</surname><given-names>Aaron</given-names></name><xref ref-type="aff" rid="aff22"><sup>22</sup></xref><xref ref-type="aff" rid="aff23"><sup>23</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rao</surname><given-names>Madhumathi</given-names></name><xref ref-type="aff" rid="aff24"><sup>24</sup></xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Albert V.</given-names></name><xref ref-type="aff" rid="aff25"><sup>25</sup></xref><xref ref-type="aff" rid="aff26"><sup>26</sup></xref></contrib><contrib contrib-type="author"><name><surname>O’Connell</surname><given-names>Jeffrey R.</given-names></name><xref ref-type="aff" rid="aff17"><sup>17</sup></xref></contrib><contrib contrib-type="author"><name><surname>Struchalin</surname><given-names>Maksim</given-names></name><xref ref-type="aff" rid="aff27"><sup>27</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tanaka</surname><given-names>Toshiko</given-names></name><xref ref-type="aff" rid="aff28"><sup>28</sup></xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Guo</given-names></name><xref ref-type="aff" rid="aff29"><sup>29</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hwang</surname><given-names>Shih-Jen</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Atkinson</surname><given-names>Elizabeth J.</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lohman</surname><given-names>Kurt</given-names></name><xref ref-type="aff" rid="aff30"><sup>30</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cornelis</surname><given-names>Marilyn C.</given-names></name><xref ref-type="aff" rid="aff31"><sup>31</sup></xref></contrib><contrib contrib-type="author"><name><surname>Johansson</surname><given-names>Åsa</given-names></name><xref ref-type="aff" rid="aff32"><sup>32</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tönjes</surname><given-names>Anke</given-names></name><xref ref-type="aff" rid="aff33"><sup>33</sup></xref><xref ref-type="aff" rid="aff34"><sup>34</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dehghan</surname><given-names>Abbas</given-names></name><xref ref-type="aff" rid="aff35"><sup>35</sup></xref></contrib><contrib contrib-type="author"><name><surname>Couraki</surname><given-names>Vincent</given-names></name><xref ref-type="aff" rid="aff36"><sup>36</sup></xref></contrib><contrib contrib-type="author"><name><surname>Holliday</surname><given-names>Elizabeth G.</given-names></name><xref ref-type="aff" rid="aff37"><sup>37</sup></xref><xref ref-type="aff" rid="aff38"><sup>38</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sorice</surname><given-names>Rossella</given-names></name><xref ref-type="aff" rid="aff39"><sup>39</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kutalik</surname><given-names>Zoltan</given-names></name><xref ref-type="aff" rid="aff40"><sup>40</sup></xref><xref ref-type="aff" rid="aff41"><sup>41</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lehtimäki</surname><given-names>Terho</given-names></name><xref ref-type="aff" rid="aff42"><sup>42</sup></xref></contrib><contrib contrib-type="author"><name><surname>Esko</surname><given-names>Tõnu</given-names></name><xref ref-type="aff" rid="aff43"><sup>43</sup></xref><xref ref-type="aff" rid="aff44"><sup>44</sup></xref></contrib><contrib contrib-type="author"><name><surname>Deshmukh</surname><given-names>Harshal</given-names></name><xref ref-type="aff" rid="aff45"><sup>45</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ulivi</surname><given-names>Sheila</given-names></name><xref ref-type="aff" rid="aff46"><sup>46</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chu</surname><given-names>Audrey Y.</given-names></name><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Murgia</surname><given-names>Federico</given-names></name><xref ref-type="aff" rid="aff47"><sup>47</sup></xref></contrib><contrib contrib-type="author"><name><surname>Trompet</surname><given-names>Stella</given-names></name><xref ref-type="aff" rid="aff48"><sup>48</sup></xref></contrib><contrib contrib-type="author"><name><surname>Imboden</surname><given-names>Medea</given-names></name><xref ref-type="aff" rid="aff49"><sup>49</sup></xref><xref ref-type="aff" rid="aff50"><sup>50</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kollerits</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="aff51"><sup>51</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pistis</surname><given-names>Giorgio</given-names></name><xref ref-type="aff" rid="aff52"><sup>52</sup></xref></contrib><contrib contrib-type="author"><name><surname>Harris</surname><given-names>Tamara B.</given-names></name><xref ref-type="aff" rid="aff53"><sup>53</sup></xref></contrib><contrib contrib-type="author"><name><surname>Launer</surname><given-names>Lenore J.</given-names></name><xref ref-type="aff" rid="aff53"><sup>53</sup></xref></contrib><contrib contrib-type="author"><name><surname>Aspelund</surname><given-names>Thor</given-names></name><xref ref-type="aff" rid="aff25"><sup>25</sup></xref><xref ref-type="aff" rid="aff26"><sup>26</sup></xref></contrib><contrib contrib-type="author"><name><surname>Eiriksdottir</surname><given-names>Gudny</given-names></name><xref ref-type="aff" rid="aff25"><sup>25</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mitchell</surname><given-names>Braxton D.</given-names></name><xref ref-type="aff" rid="aff17"><sup>17</sup></xref></contrib><contrib contrib-type="author"><name><surname>Boerwinkle</surname><given-names>Eric</given-names></name><xref ref-type="aff" rid="aff54"><sup>54</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Helena</given-names></name><xref ref-type="aff" rid="aff55"><sup>55</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hofer</surname><given-names>Edith</given-names></name><xref ref-type="aff" rid="aff56"><sup>56</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hu</surname><given-names>Frank</given-names></name><xref ref-type="aff" rid="aff31"><sup>31</sup></xref></contrib><contrib contrib-type="author"><name><surname>Demirkan</surname><given-names>Ayse</given-names></name><xref ref-type="aff" rid="aff22"><sup>22</sup></xref></contrib><contrib contrib-type="author"><name><surname>Oostra</surname><given-names>Ben A.</given-names></name><xref ref-type="aff" rid="aff22"><sup>22</sup></xref><xref ref-type="aff" rid="aff57"><sup>57</sup></xref></contrib><contrib contrib-type="author"><name><surname>Turner</surname><given-names>Stephen T.</given-names></name><xref ref-type="aff" rid="aff58"><sup>58</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ding</surname><given-names>Jingzhong</given-names></name><xref ref-type="aff" rid="aff59"><sup>59</sup></xref></contrib><contrib contrib-type="author"><name><surname>Andrews</surname><given-names>Jeanette S.</given-names></name><xref ref-type="aff" rid="aff60"><sup>60</sup></xref></contrib><contrib contrib-type="author"><name><surname>Freedman</surname><given-names>Barry I.</given-names></name><xref ref-type="aff" rid="aff61"><sup>61</sup></xref></contrib><contrib contrib-type="author"><name><surname>Giulianini</surname><given-names>Franco</given-names></name><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Koenig</surname><given-names>Wolfgang</given-names></name><xref ref-type="aff" rid="aff62"><sup>62</sup></xref></contrib><contrib contrib-type="author"><name><surname>Illig</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="aff63"><sup>63</sup></xref><xref ref-type="aff" rid="aff64"><sup>64</sup></xref></contrib><contrib contrib-type="author"><name><surname>Döring</surname><given-names>Angela</given-names></name><xref ref-type="aff" rid="aff65"><sup>65</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wichmann</surname><given-names>H.-Erich</given-names></name><xref ref-type="aff" rid="aff65"><sup>65</sup></xref><xref ref-type="aff" rid="aff66"><sup>66</sup></xref><xref ref-type="aff" rid="aff67"><sup>67</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zgaga</surname><given-names>Lina</given-names></name><xref ref-type="aff" rid="aff68"><sup>68</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zemunik</surname><given-names>Tatijana</given-names></name><xref ref-type="aff" rid="aff69"><sup>69</sup></xref></contrib><contrib contrib-type="author"><name><surname>Boban</surname><given-names>Mladen</given-names></name><xref ref-type="aff" rid="aff69"><sup>69</sup></xref></contrib><contrib contrib-type="author"><name><surname>Minelli</surname><given-names>Cosetta</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wheeler</surname><given-names>Heather E.</given-names></name><xref ref-type="aff" rid="aff70"><sup>70</sup></xref><xref ref-type="aff" rid="aff71"><sup>71</sup></xref></contrib><contrib contrib-type="author"><name><surname>Igl</surname><given-names>Wilmar</given-names></name><xref ref-type="aff" rid="aff32"><sup>32</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zaboli</surname><given-names>Ghazal</given-names></name><xref ref-type="aff" rid="aff32"><sup>32</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wild</surname><given-names>Sarah H.</given-names></name><xref ref-type="aff" rid="aff68"><sup>68</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wright</surname><given-names>Alan F.</given-names></name><xref ref-type="aff" rid="aff72"><sup>72</sup></xref></contrib><contrib contrib-type="author"><name><surname>Campbell</surname><given-names>Harry</given-names></name><xref ref-type="aff" rid="aff68"><sup>68</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ellinghaus</surname><given-names>David</given-names></name><xref ref-type="aff" rid="aff73"><sup>73</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nöthlings</surname><given-names>Ute</given-names></name><xref ref-type="aff" rid="aff74"><sup>74</sup></xref><xref ref-type="aff" rid="aff75"><sup>75</sup></xref><xref ref-type="aff" rid="aff76"><sup>76</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jacobs</surname><given-names>Gunnar</given-names></name><xref ref-type="aff" rid="aff74"><sup>74</sup></xref><xref ref-type="aff" rid="aff75"><sup>75</sup></xref></contrib><contrib contrib-type="author"><name><surname>Biffar</surname><given-names>Reiner</given-names></name><xref ref-type="aff" rid="aff77"><sup>77</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ernst</surname><given-names>Florian</given-names></name><xref ref-type="aff" rid="aff11"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Homuth</surname><given-names>Georg</given-names></name><xref ref-type="aff" rid="aff11"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kroemer</surname><given-names>Heyo K.</given-names></name><xref ref-type="aff" rid="aff78"><sup>78</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nauck</surname><given-names>Matthias</given-names></name><xref ref-type="aff" rid="aff79"><sup>79</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stracke</surname><given-names>Sylvia</given-names></name><xref ref-type="aff" rid="aff80"><sup>80</sup></xref></contrib><contrib contrib-type="author"><name><surname>Völker</surname><given-names>Uwe</given-names></name><xref ref-type="aff" rid="aff11"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Völzke</surname><given-names>Henry</given-names></name><xref ref-type="aff" rid="aff81"><sup>81</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kovacs</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="aff33"><sup>33</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stumvoll</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="aff33"><sup>33</sup></xref><xref ref-type="aff" rid="aff34"><sup>34</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mägi</surname><given-names>Reedik</given-names></name><xref ref-type="aff" rid="aff43"><sup>43</sup></xref><xref ref-type="aff" rid="aff82"><sup>82</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hofman</surname><given-names>Albert</given-names></name><xref ref-type="aff" rid="aff35"><sup>35</sup></xref></contrib><contrib contrib-type="author"><name><surname>Uitterlinden</surname><given-names>Andre G.</given-names></name><xref ref-type="aff" rid="aff83"><sup>83</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rivadeneira</surname><given-names>Fernando</given-names></name><xref ref-type="aff" rid="aff83"><sup>83</sup></xref></contrib><contrib contrib-type="author"><name><surname>Aulchenko</surname><given-names>Yurii S.</given-names></name><xref ref-type="aff" rid="aff35"><sup>35</sup></xref></contrib><contrib contrib-type="author"><name><surname>Polasek</surname><given-names>Ozren</given-names></name><xref ref-type="aff" rid="aff69"><sup>69</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hastie</surname><given-names>Nick</given-names></name><xref ref-type="aff" rid="aff72"><sup>72</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vitart</surname><given-names>Veronique</given-names></name><xref ref-type="aff" rid="aff72"><sup>72</sup></xref></contrib><contrib contrib-type="author"><name><surname>Helmer</surname><given-names>Catherine</given-names></name><xref ref-type="aff" rid="aff84"><sup>84</sup></xref><xref ref-type="aff" rid="aff85"><sup>85</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Jie Jin</given-names></name><xref ref-type="aff" rid="aff86"><sup>86</sup></xref><xref ref-type="aff" rid="aff87"><sup>87</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stengel</surname><given-names>Bénédicte</given-names></name><xref ref-type="aff" rid="aff88"><sup>88</sup></xref><xref ref-type="aff" rid="aff89"><sup>89</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ruggiero</surname><given-names>Daniela</given-names></name><xref ref-type="aff" rid="aff39"><sup>39</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bergmann</surname><given-names>Sven</given-names></name><xref ref-type="aff" rid="aff41"><sup>41</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kähönen</surname><given-names>Mika</given-names></name><xref ref-type="aff" rid="aff90"><sup>90</sup></xref></contrib><contrib contrib-type="author"><name><surname>Viikari</surname><given-names>Jorma</given-names></name><xref ref-type="aff" rid="aff91"><sup>91</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nikopensius</surname><given-names>Tiit</given-names></name><xref ref-type="aff" rid="aff44"><sup>44</sup></xref></contrib><contrib contrib-type="author"><name><surname>Province</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="aff19"><sup>19</sup></xref></contrib><contrib contrib-type="author"><name><surname>Colhoun</surname><given-names>Helen</given-names></name><xref ref-type="aff" rid="aff45"><sup>45</sup></xref></contrib><contrib contrib-type="author"><name><surname>Doney</surname><given-names>Alex</given-names></name><xref ref-type="aff" rid="aff92"><sup>92</sup></xref></contrib><contrib contrib-type="author"><name><surname>Robino</surname><given-names>Antonietta</given-names></name><xref ref-type="aff" rid="aff46"><sup>46</sup></xref></contrib><contrib contrib-type="author"><name><surname>Krämer</surname><given-names>Bernhard K.</given-names></name><xref ref-type="aff" rid="aff93"><sup>93</sup></xref></contrib><contrib contrib-type="author"><name><surname>Portas</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="aff47"><sup>47</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ford</surname><given-names>Ian</given-names></name><xref ref-type="aff" rid="aff94"><sup>94</sup></xref></contrib><contrib contrib-type="author"><name><surname>Buckley</surname><given-names>Brendan M.</given-names></name><xref ref-type="aff" rid="aff95"><sup>95</sup></xref></contrib><contrib contrib-type="author"><name><surname>Adam</surname><given-names>Martin</given-names></name><xref ref-type="aff" rid="aff49"><sup>49</sup></xref><xref ref-type="aff" rid="aff50"><sup>50</sup></xref></contrib><contrib contrib-type="author"><name><surname>Thun</surname><given-names>Gian-Andri</given-names></name><xref ref-type="aff" rid="aff49"><sup>49</sup></xref><xref ref-type="aff" rid="aff50"><sup>50</sup></xref></contrib><contrib contrib-type="author"><name><surname>Paulweber</surname><given-names>Bernhard</given-names></name><xref ref-type="aff" rid="aff96"><sup>96</sup></xref></contrib><contrib contrib-type="author"><name><surname>Haun</surname><given-names>Margot</given-names></name><xref ref-type="aff" rid="aff51"><sup>51</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sala</surname><given-names>Cinzia</given-names></name><xref ref-type="aff" rid="aff52"><sup>52</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mitchell</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="aff86"><sup>86</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ciullo</surname><given-names>Marina</given-names></name><xref ref-type="aff" rid="aff39"><sup>39</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vollenweider</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="aff97"><sup>97</sup></xref></contrib><contrib contrib-type="author"><name><surname>Raitakari</surname><given-names>Olli</given-names></name><xref ref-type="aff" rid="aff98"><sup>98</sup></xref></contrib><contrib contrib-type="author"><name><surname>Metspalu</surname><given-names>Andres</given-names></name><xref ref-type="aff" rid="aff43"><sup>43</sup></xref><xref ref-type="aff" rid="aff44"><sup>44</sup></xref></contrib><contrib contrib-type="author"><name><surname>Palmer</surname><given-names>Colin</given-names></name><xref ref-type="aff" rid="aff99"><sup>99</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gasparini</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="aff46"><sup>46</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pirastu</surname><given-names>Mario</given-names></name><xref ref-type="aff" rid="aff47"><sup>47</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jukema</surname><given-names>J. Wouter</given-names></name><xref ref-type="aff" rid="aff48"><sup>48</sup></xref><xref ref-type="aff" rid="aff100"><sup>100</sup></xref><xref ref-type="aff" rid="aff101"><sup>101</sup></xref><xref ref-type="aff" rid="aff102"><sup>102</sup></xref></contrib><contrib contrib-type="author"><name><surname>Probst-Hensch</surname><given-names>Nicole M.</given-names></name><xref ref-type="aff" rid="aff49"><sup>49</sup></xref><xref ref-type="aff" rid="aff50"><sup>50</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kronenberg</surname><given-names>Florian</given-names></name><xref ref-type="aff" rid="aff51"><sup>51</sup></xref></contrib><contrib contrib-type="author"><name><surname>Toniolo</surname><given-names>Daniela</given-names></name><xref ref-type="aff" rid="aff52"><sup>52</sup></xref><xref ref-type="aff" rid="aff103"><sup>103</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gudnason</surname><given-names>Vilmundur</given-names></name><xref ref-type="aff" rid="aff25"><sup>25</sup></xref><xref ref-type="aff" rid="aff26"><sup>26</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shuldiner</surname><given-names>Alan R.</given-names></name><xref ref-type="aff" rid="aff17"><sup>17</sup></xref><xref ref-type="aff" rid="aff104"><sup>104</sup></xref></contrib><contrib contrib-type="author"><name><surname>Coresh</surname><given-names>Josef</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><xref ref-type="aff" rid="aff105"><sup>105</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Reinhold</given-names></name><xref ref-type="aff" rid="aff56"><sup>56</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ferrucci</surname><given-names>Luigi</given-names></name><xref ref-type="aff" rid="aff28"><sup>28</sup></xref></contrib><contrib contrib-type="author"><name><surname>van Duijn</surname><given-names>Cornelia M.</given-names></name><xref ref-type="aff" rid="aff22"><sup>22</sup></xref><xref ref-type="aff" rid="aff23"><sup>23</sup></xref><xref ref-type="aff" rid="aff106"><sup>106</sup></xref></contrib><contrib contrib-type="author"><name><surname>Borecki</surname><given-names>Ingrid</given-names></name><xref ref-type="aff" rid="aff19"><sup>19</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kardia</surname><given-names>Sharon L.R.</given-names></name><xref ref-type="aff" rid="aff107"><sup>107</sup></xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Yongmei</given-names></name><xref ref-type="aff" rid="aff30"><sup>30</sup></xref></contrib><contrib contrib-type="author"><name><surname>Curhan</surname><given-names>Gary C.</given-names></name><xref ref-type="aff" rid="aff108"><sup>108</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rudan</surname><given-names>Igor</given-names></name><xref ref-type="aff" rid="aff68"><sup>68</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gyllensten</surname><given-names>Ulf</given-names></name><xref ref-type="aff" rid="aff32"><sup>32</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>James F.</given-names></name><xref ref-type="aff" rid="aff68"><sup>68</sup></xref></contrib><contrib contrib-type="author"><name><surname>Franke</surname><given-names>Andre</given-names></name><xref ref-type="aff" rid="aff73"><sup>73</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pramstaller</surname><given-names>Peter P.</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rettig</surname><given-names>Rainer</given-names></name><xref ref-type="aff" rid="aff109"><sup>109</sup></xref></contrib><contrib contrib-type="author"><name><surname>Prokopenko</surname><given-names>Inga</given-names></name><xref ref-type="aff" rid="aff82"><sup>82</sup></xref><xref ref-type="aff" rid="aff110"><sup>110</sup></xref></contrib><contrib contrib-type="author"><name><surname>Witteman</surname><given-names>Jacqueline</given-names></name><xref ref-type="aff" rid="aff35"><sup>35</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hayward</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="aff72"><sup>72</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ridker</surname><given-names>Paul M.</given-names></name><xref ref-type="aff" rid="aff9"><sup>9</sup></xref><xref ref-type="aff" rid="aff10"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bochud</surname><given-names>Murielle</given-names></name><xref ref-type="aff" rid="aff111"><sup>111</sup></xref></contrib><contrib contrib-type="author"><name><surname>Heid</surname><given-names>Iris M.</given-names></name><xref ref-type="aff" rid="aff14"><sup>14</sup></xref><xref ref-type="aff" rid="aff112"><sup>112</sup></xref></contrib><contrib contrib-type="author"><name><surname>Siscovick</surname><given-names>David S.</given-names></name><xref ref-type="aff" rid="aff29"><sup>29</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fox</surname><given-names>Caroline S.</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref><xref ref-type="aff" rid="aff113"><sup>113</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kao</surname><given-names>W. Linda</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><xref ref-type="aff" rid="aff105"><sup>105</sup></xref></contrib><contrib contrib-type="author"><name><surname>Böger</surname><given-names>Carsten A.</given-names></name><xref ref-type="aff" rid="aff13"><sup>13</sup></xref></contrib><aff id="aff1"><label>1</label>Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland;</aff><aff id="aff2"><label>2</label>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan;</aff><aff id="aff3"><label>3</label>Renal Division, Freiburg University Clinic, Freiburg, Germany;</aff><aff id="aff4"><label>4</label>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;</aff><aff id="aff5"><label>5</label>National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts;</aff><aff id="aff6"><label>6</label>Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts;</aff><aff id="aff7"><label>7</label>Centre for Biomedicine, European Academy of Bozen/Bolzano, Bolzano, Italy;</aff><aff id="aff8"><label>8</label>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota;</aff><aff id="aff9"><label>9</label>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts;</aff><aff id="aff10"><label>10</label>Harvard Medical School, Boston, Massachusetts;</aff><aff id="aff11"><label>11</label>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany;</aff><aff id="aff12"><label>12</label>Institute of Anatomy and Cell Biology, University of Greifswald, Greifswald, Germany;</aff><aff id="aff13"><label>13</label>Division of Nephrology, Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany;</aff><aff id="aff14"><label>14</label>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany;</aff><aff id="aff15"><label>15</label>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts;</aff><aff id="aff16"><label>16</label>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts;</aff><aff id="aff17"><label>17</label>Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland;</aff><aff id="aff18"><label>18</label>Genomics Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea;</aff><aff id="aff19"><label>19</label>Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri;</aff><aff id="aff20"><label>20</label>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany;</aff><aff id="aff21"><label>21</label>Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts;</aff><aff id="aff22"><label>22</label>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands;</aff><aff id="aff23"><label>23</label>Centre for Medical Systems Biology, Rotterdam, The Netherlands;</aff><aff id="aff24"><label>24</label>Division of Nephrology, Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts;</aff><aff id="aff25"><label>25</label>Research Institute, Icelandic Heart Association, Kopavogur, Iceland;</aff><aff id="aff26"><label>26</label>University of Iceland, Reykjavik, Iceland;</aff><aff id="aff27"><label>27</label>Departments of Epidemiology and Biostatistics and Forensic Molecular Biology, Erasmus Medical Center, Rotterdam, The Netherlands;</aff><aff id="aff28"><label>28</label>Clinical Research Branch, National Institute of Aging, Baltimore Maryland;</aff><aff id="aff29"><label>29</label>University of Washington, Seattle, Washington;</aff><aff id="aff30"><label>30</label>Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina;</aff><aff id="aff31"><label>31</label>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts;</aff><aff id="aff32"><label>32</label>Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden;</aff><aff id="aff33"><label>33</label>Department of Medicine, University of Leipzig, Leipzig, Germany;</aff><aff id="aff34"><label>34</label>Adiposity Diseases Integrated Research and Treatment Center, University of Leipzig, Leipzig, Germany;</aff><aff id="aff35"><label>35</label>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;</aff><aff id="aff36"><label>36</label>INSERM UMR744, Institut Pasteur, Lille, France;</aff><aff id="aff37"><label>37</label>Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia;</aff><aff id="aff38"><label>38</label>Centre for Information-Based Medicine, Hunter Medical Research Institute, Newcastle, Australia;</aff><aff id="aff39"><label>39</label>Adriano-Buzzati Traverso-CNR Institute of Genetics and Biophysics, Naples, Italy;</aff><aff id="aff40"><label>40</label>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland;</aff><aff id="aff41"><label>41</label>Swiss Institute of Bioinformatics, Lausanne, Switzerland;</aff><aff id="aff42"><label>42</label>Fimlab Laboratories, Department of Clinical Chemistry, School of Medicine, University of Tampere, Tampere, Finland;</aff><aff id="aff43"><label>43</label>Estonian Genome Center, University of Tartu, Tartu, Estonia;</aff><aff id="aff44"><label>44</label>Institute of Molecular and Cell Biology, Estonian Biocentre, University of Tartu, Tartu, Estonia;</aff><aff id="aff45"><label>45</label>Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, University of Dundee, Ninewells Hospital, Dundee, United Kingdom;</aff><aff id="aff46"><label>46</label>IRCCS Burlo Garofolo Institute for Maternal and Child Health, University of Trieste, Trieste, Italy;</aff><aff id="aff47"><label>47</label>CNR Institute of Population Genetics, Sassari, Italy;</aff><aff id="aff48"><label>48</label>Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands;</aff><aff id="aff49"><label>49</label>Swiss Tropical and Public Health Institute, Basel, Switzerland;</aff><aff id="aff50"><label>50</label>University of Basel, Basel, Switzerland;</aff><aff id="aff51"><label>51</label>Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria;</aff><aff id="aff52"><label>52</label>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy;</aff><aff id="aff53"><label>53</label>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland;</aff><aff id="aff54"><label>54</label>Human Genetics Center, University of Texas Health Science Center, Houston, Texas;</aff><aff id="aff55"><label>55</label>Austrian Stroke Prevention Study, Department of Neurology, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria;</aff><aff id="aff56"><label>56</label>Austrian Stroke Prevention Study, Clinical Division of Neurogeriatrics, Department of Neurology, University Clinic of Neurology, Medical University of Graz, Graz, Austria;</aff><aff id="aff57"><label>57</label>Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands;</aff><aff id="aff58"><label>58</label>Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota;</aff><aff id="aff59"><label>59</label>Division of Geriatrics, Department of Internal Medicine, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina;</aff><aff id="aff60"><label>60</label>Department of Biostatistical Sciences, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina;</aff><aff id="aff61"><label>61</label>Division of Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina;</aff><aff id="aff62"><label>62</label>Department of Internal Medicine II, Ulm University Clinic, University of Ulm, Ulm, Germany;</aff><aff id="aff63"><label>63</label>Hanover Unified Biobank, Hanover Medical School, Hanover, Germany;</aff><aff id="aff64"><label>64</label>Research Unit of Molecular Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany;</aff><aff id="aff65"><label>65</label>Institute of Epidemiology I and II, German Research Center for Environmental Health, Neuherberg, Germany;</aff><aff id="aff66"><label>66</label>Institute for Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-University, Munich, Germany;</aff><aff id="aff67"><label>67</label>Grosshadern Clinic, Neuherberg, Germany;</aff><aff id="aff68"><label>68</label>Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom;</aff><aff id="aff69"><label>69</label>Croatian Centre for Global Health, University of Split Medical School, Split, Croatia;</aff><aff id="aff70"><label>70</label>Department of Genetics, Stanford University, Stanford, California;</aff><aff id="aff71"><label>71</label>Department of Medicine, University of Chicago, Chicago, Illinois;</aff><aff id="aff72"><label>72</label>Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom;</aff><aff id="aff73"><label>73</label>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany;</aff><aff id="aff74"><label>74</label>PopGen Biobank, Schleswig-Holstein University Hospital, Kiel, Germany;</aff><aff id="aff75"><label>75</label>Institute for Epidemiology, University of Kiel, Kiel, Germany;</aff><aff id="aff76"><label>76</label>Department of Nutrition and Food Sciences, University of Bonn, Bonn, Germany;</aff><aff id="aff77"><label>77</label>Clinic for Prosthodontic Dentistry, Gerostomatology, and Material Science, University of Greifswald, Greifswald, Germany;</aff><aff id="aff78"><label>78</label>Institute of Pharmacology, University of Greifswald, Greifswald, Germany;</aff><aff id="aff79"><label>79</label>Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Greifswald, Germany;</aff><aff id="aff80"><label>80</label>Clinic for Internal Medicine A, University of Greifswald, Greifswald, Germany;</aff><aff id="aff81"><label>81</label>Institute for Community Medicine, University of Greifswald, Greifswald, Germany;</aff><aff id="aff82"><label>82</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom;</aff><aff id="aff83"><label>83</label>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands;</aff><aff id="aff84"><label>84</label>INSERM U897, Institute of Public Health, Victor Segalen Bordeaux II University, Bordeaux, France;</aff><aff id="aff85"><label>85</label>Victor Segalen Bordeaux II University, Bordeaux, France;</aff><aff id="aff86"><label>86</label>Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia;</aff><aff id="aff87"><label>87</label>Centre for Eye Research Australia, University of Melbourne, East Melbourne, Australia;</aff><aff id="aff88"><label>88</label>INSERM UMRS 1018, Villejuif, France;</aff><aff id="aff89"><label>89</label>UMRS 1018, University of Paris-Sud, Paris, France;</aff><aff id="aff90"><label>90</label>Department of Clinical Physiology, Tampere University Hospital, School of Medicine, University of Tampere, Tampere, Finland;</aff><aff id="aff91"><label>91</label>Department of Medicine, Turku University Hospital, University of Turku, Turku, Finland;</aff><aff id="aff92"><label>92</label>National Health Service Tayside, Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, Dundee, United Kingdom;</aff><aff id="aff93"><label>93</label>Fifth Department of Medicine, Mannheim University Medical Centre, Mannheim, Germany;</aff><aff id="aff94"><label>94</label>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom;</aff><aff id="aff95"><label>95</label>Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland;</aff><aff id="aff96"><label>96</label>First Department of Internal Medicine, Paracelsus Medical University, Salzburg, Austria;</aff><aff id="aff97"><label>97</label>Department of Internal Medicine, Vaudois University Hospital Center, University of Lausanne, Lausanne, Switzerland;</aff><aff id="aff98"><label>98</label>Research Centre of Applied and Preventive Cardiovascular Medicine, Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland;</aff><aff id="aff99"><label>99</label>Biomedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom;</aff><aff id="aff100"><label>100</label>Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands;</aff><aff id="aff101"><label>101</label>Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands;</aff><aff id="aff102"><label>102</label>Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands;</aff><aff id="aff103"><label>103</label>CNR Institute of Molecular Genetics, Pavia, Italy;</aff><aff id="aff104"><label>104</label>Geriatric Research and Education Clinical Center, Veterans Affairs Medical Center, Baltimore, Maryland;</aff><aff id="aff105"><label>105</label>Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland;</aff><aff id="aff106"><label>106</label>Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, Leiden, the Netherlands;</aff><aff id="aff107"><label>107</label>Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan;</aff><aff id="aff108"><label>108</label>Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts;</aff><aff id="aff109"><label>109</label>Institute of Physiology, University of Greifswald, Karlsburg, Germany;</aff><aff id="aff110"><label>110</label>Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom;</aff><aff id="aff111"><label>111</label>University Institute of Social and Preventive Medicine, Vaudois University Hospital Center, University of Lausanne, Lausanne, Switzerland;</aff><aff id="aff112"><label>112</label>Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany; and</aff><aff id="aff113"><label>113</label>Division of Endocrinology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts</aff></contrib-group><author-notes><corresp id="cor1"><bold>Correspondence:</bold> Dr. Afshin Parsa, <addr-line>Division of Nephrology, University of Maryland School of Medicine, 685 W. Baltimore Street, MSTF 314, Baltimore, MD, 21201</addr-line>. Email: <email>aparsa@medicine.umaryland.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>12</day><month>9</month><year>2013</year></pub-date><volume>24</volume><issue>12</issue><fpage>2105</fpage><lpage>2117</lpage><history><date date-type="received"><day>8</day><month>10</month><year>2012</year></date><date date-type="accepted"><day>10</day><month>7</month><year>2013</year></date></history><permissions><copyright-statement>Copyright © 2013 by the American Society of Nephrology</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="ASN.2012100983.pdf"></self-uri><abstract><p>Many common genetic variants identified by genome-wide association studies for complex traits map to genes previously linked to rare inherited Mendelian disorders. A systematic analysis of common single-nucleotide polymorphisms (SNPs) in genes responsible for Mendelian diseases with kidney phenotypes has not been performed. We thus developed a comprehensive database of genes for Mendelian kidney conditions and evaluated the association between common genetic variants within these genes and kidney function in the general population. Using the Online Mendelian Inheritance in Man database, we identified 731 unique disease entries related to specific renal search terms and confirmed a kidney phenotype in 218 of these entries, corresponding to mutations in 258 genes. We interrogated common SNPs (minor allele frequency >5%) within these genes for association with the estimated GFR in 74,354 European-ancestry participants from the CKDGen Consortium. However, the top four candidate SNPs (rs6433115 at <italic>LRP2</italic>, rs1050700 at <italic>TSC1</italic>, rs249942 at <italic>PALB2</italic>, and rs9827843 at <italic>ROBO2</italic>) did not achieve significance in a stage 2 meta-analysis performed in 56,246 additional independent individuals, indicating that these common SNPs are not associated with estimated GFR. The effect of less common or rare variants in these genes on kidney function in the general population and disease-specific cohorts requires further research.</p></abstract><counts><page-count count="13"></page-count></counts><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>December 2013</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001904 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001904 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |