Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7</title>
<author><name sortKey="Huntington, Nicholas D" sort="Huntington, Nicholas D" uniqKey="Huntington N" first="Nicholas D." last="Huntington">Nicholas D. Huntington</name>
<affiliation><nlm:aff id="aff1">Cytokines and Lymphoid Development Unit, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Inserm U668, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Labi, Verena" sort="Labi, Verena" uniqKey="Labi V" first="Verena" last="Labi">Verena Labi</name>
<affiliation><nlm:aff id="aff3">Division of Developmental Immunology, Department of Biocenter, Innsbruck Medical University, Innsbruck, Austria</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cumano, Ana" sort="Cumano, Ana" uniqKey="Cumano A" first="Ana" last="Cumano">Ana Cumano</name>
<affiliation><nlm:aff id="aff2">Inserm U668, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff4">Lymphocyte Development Unit, Institut Pasteur, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vieira, Paulo" sort="Vieira, Paulo" uniqKey="Vieira P" first="Paulo" last="Vieira">Paulo Vieira</name>
<affiliation><nlm:aff id="aff2">Inserm U668, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff4">Lymphocyte Development Unit, Institut Pasteur, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Strasser, Andreas" sort="Strasser, Andreas" uniqKey="Strasser A" first="Andreas" last="Strasser">Andreas Strasser</name>
<affiliation><nlm:aff id="aff5">Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Villunger, Andreas" sort="Villunger, Andreas" uniqKey="Villunger A" first="Andreas" last="Villunger">Andreas Villunger</name>
<affiliation><nlm:aff id="aff3">Division of Developmental Immunology, Department of Biocenter, Innsbruck Medical University, Innsbruck, Austria</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Di Santo, James P" sort="Di Santo, James P" uniqKey="Di Santo J" first="James P." last="Di Santo">James P. Di Santo</name>
<affiliation><nlm:aff id="aff1">Cytokines and Lymphoid Development Unit, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Inserm U668, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Alves, Nuno L" sort="Alves, Nuno L" uniqKey="Alves N" first="Nuno L." last="Alves">Nuno L. Alves</name>
<affiliation><nlm:aff id="aff1">Cytokines and Lymphoid Development Unit, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Inserm U668, Paris, France</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19454543</idno>
<idno type="pmc">2980998</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980998</idno>
<idno type="RBID">PMC:2980998</idno>
<idno type="doi">10.1093/intimm/dxp043</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">001897</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001897</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7</title>
<author><name sortKey="Huntington, Nicholas D" sort="Huntington, Nicholas D" uniqKey="Huntington N" first="Nicholas D." last="Huntington">Nicholas D. Huntington</name>
<affiliation><nlm:aff id="aff1">Cytokines and Lymphoid Development Unit, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Inserm U668, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Labi, Verena" sort="Labi, Verena" uniqKey="Labi V" first="Verena" last="Labi">Verena Labi</name>
<affiliation><nlm:aff id="aff3">Division of Developmental Immunology, Department of Biocenter, Innsbruck Medical University, Innsbruck, Austria</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cumano, Ana" sort="Cumano, Ana" uniqKey="Cumano A" first="Ana" last="Cumano">Ana Cumano</name>
<affiliation><nlm:aff id="aff2">Inserm U668, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff4">Lymphocyte Development Unit, Institut Pasteur, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vieira, Paulo" sort="Vieira, Paulo" uniqKey="Vieira P" first="Paulo" last="Vieira">Paulo Vieira</name>
<affiliation><nlm:aff id="aff2">Inserm U668, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff4">Lymphocyte Development Unit, Institut Pasteur, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Strasser, Andreas" sort="Strasser, Andreas" uniqKey="Strasser A" first="Andreas" last="Strasser">Andreas Strasser</name>
<affiliation><nlm:aff id="aff5">Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Villunger, Andreas" sort="Villunger, Andreas" uniqKey="Villunger A" first="Andreas" last="Villunger">Andreas Villunger</name>
<affiliation><nlm:aff id="aff3">Division of Developmental Immunology, Department of Biocenter, Innsbruck Medical University, Innsbruck, Austria</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Di Santo, James P" sort="Di Santo, James P" uniqKey="Di Santo J" first="James P." last="Di Santo">James P. Di Santo</name>
<affiliation><nlm:aff id="aff1">Cytokines and Lymphoid Development Unit, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Inserm U668, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Alves, Nuno L" sort="Alves, Nuno L" uniqKey="Alves N" first="Nuno L." last="Alves">Nuno L. Alves</name>
<affiliation><nlm:aff id="aff1">Cytokines and Lymphoid Development Unit, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Inserm U668, Paris, France</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">International Immunology</title>
<idno type="ISSN">0953-8178</idno>
<idno type="eISSN">1460-2377</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>IL-7 is pivotal for B cell development. Proteins of the Bcl-2 family are essential regulators of lymphocyte survival. Particularly, the pro-apoptotic BH3-only members Bim and Puma mediate lymphocyte apoptosis provoked by cytokine deprivation. Herein, we addressed whether the absence of Bim or Puma within the hematopoietic compartment could bypass the requirement for IL-7-driven B cell development in adult mice. We found that deficiency of Bim, but not Puma, partially rescued B cell development in the absence of IL-7. The numbers of both sIgM<sup>−</sup>
and sIgM<sup>+</sup>
B cells were markedly increased in the bone marrow of recipients lacking IL-7 upon reconstitution with Bim-deficient hematopoietic progenitors, compared with their control or Puma-deficient counterparts. The augmentation of B cell lymphopoiesis in the absence of Bim was reflected in the mature peripheral compartment by an increase in both the number of immature and mature B cells in the spleen and in the circulating IgM levels. Bim-deficient B cells were also increased in IL-7-sufficient recipients suggesting that peripheral B cells homeostasis is governed by a Bim-dependent and IL-7-independent mechanism. Our data highlight the role of Bim as a key regulator of cell survival during B lymphocyte development <italic>in vivo</italic>
.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int Immunol</journal-id>
<journal-id journal-id-type="hwp">intimm</journal-id>
<journal-id journal-id-type="publisher-id">intimm</journal-id>
<journal-title-group><journal-title>International Immunology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0953-8178</issn>
<issn pub-type="epub">1460-2377</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19454543</article-id>
<article-id pub-id-type="pmc">2980998</article-id>
<article-id pub-id-type="doi">10.1093/intimm/dxp043</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Research Papers</subject>
</subj-group>
</article-categories>
<title-group><article-title>Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Huntington</surname>
<given-names>Nicholas D.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Labi</surname>
<given-names>Verena</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cumano</surname>
<given-names>Ana</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vieira</surname>
<given-names>Paulo</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Strasser</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Villunger</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Di Santo</surname>
<given-names>James P.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Alves</surname>
<given-names>Nuno L.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
Cytokines and Lymphoid Development Unit, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France</aff>
<aff id="aff2"><label>2</label>
Inserm U668, Paris, France</aff>
<aff id="aff3"><label>3</label>
Division of Developmental Immunology, Department of Biocenter, Innsbruck Medical University, Innsbruck, Austria</aff>
<aff id="aff4"><label>4</label>
Lymphocyte Development Unit, Institut Pasteur, Paris, France</aff>
<aff id="aff5"><label>5</label>
Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia</aff>
<author-notes><corresp><italic>Correspondence to</italic>
: N. L. Alves; E-mail: <email>nalves@pasteur.fr</email>
</corresp>
<fn><p><italic>Transmitting editor</italic>
: D. Tarlinton</p>
</fn>
</author-notes>
<pmc-comment>Fake ppub date generated by PMC from publisher pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>6</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="epub"><day>19</day>
<month>5</month>
<year>2009</year>
</pub-date>
<volume>21</volume>
<issue>6</issue>
<fpage>715</fpage>
<lpage>725</lpage>
<history><date date-type="received"><day>12</day>
<month>1</month>
<year>2009</year>
</date>
<date date-type="accepted"><day>13</day>
<month>4</month>
<year>2009</year>
</date>
</history>
<permissions><copyright-statement>© The Japanese Society for Immunology. 2009. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org</copyright-statement>
<copyright-year>2009</copyright-year>
</permissions>
<abstract><p>IL-7 is pivotal for B cell development. Proteins of the Bcl-2 family are essential regulators of lymphocyte survival. Particularly, the pro-apoptotic BH3-only members Bim and Puma mediate lymphocyte apoptosis provoked by cytokine deprivation. Herein, we addressed whether the absence of Bim or Puma within the hematopoietic compartment could bypass the requirement for IL-7-driven B cell development in adult mice. We found that deficiency of Bim, but not Puma, partially rescued B cell development in the absence of IL-7. The numbers of both sIgM<sup>−</sup>
and sIgM<sup>+</sup>
B cells were markedly increased in the bone marrow of recipients lacking IL-7 upon reconstitution with Bim-deficient hematopoietic progenitors, compared with their control or Puma-deficient counterparts. The augmentation of B cell lymphopoiesis in the absence of Bim was reflected in the mature peripheral compartment by an increase in both the number of immature and mature B cells in the spleen and in the circulating IgM levels. Bim-deficient B cells were also increased in IL-7-sufficient recipients suggesting that peripheral B cells homeostasis is governed by a Bim-dependent and IL-7-independent mechanism. Our data highlight the role of Bim as a key regulator of cell survival during B lymphocyte development <italic>in vivo</italic>
.</p>
</abstract>
<kwd-group><kwd>Bim</kwd>
<kwd>B lymphopoiesis</kwd>
<kwd>IL-7</kwd>
<kwd>Puma</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001897 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001897 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Pmc |étape= Corpus |type= RBID |clé= |texte= }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |