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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Common variants in <italic>LSP1</italic>
, 2q35 and 8q24 and breast cancer risk for <italic>BRCA1</italic>
and <italic>BRCA2</italic>
mutation carriers</title>
<author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name>
<affiliation><nlm:aff id="af2"><addr-line>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents</addr-line>
,<institution>Hospices Civils de Lyon/Centre Léon Bérard, UMR5201 CNRS, Université de Lyon</institution>
,<addr-line>Lyon</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name>
<affiliation><nlm:aff id="af3"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane, QLD 4029</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation><nlm:aff id="af4"><addr-line>Department of Obstetrics and Gynecology</addr-line>
,<institution>Helsinki University Central Hospital</institution>
,<addr-line>Helsinki</addr-line>
,<country>Finland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Heikkinen, Tuomas" sort="Heikkinen, Tuomas" uniqKey="Heikkinen T" first="Tuomas" last="Heikkinen">Tuomas Heikkinen</name>
<affiliation><nlm:aff id="af4"><addr-line>Department of Obstetrics and Gynecology</addr-line>
,<institution>Helsinki University Central Hospital</institution>
,<addr-line>Helsinki</addr-line>
,<country>Finland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<affiliation><nlm:aff id="af5"><addr-line>Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory</addr-line>
,<institution>Centre Hospitalier Universitaire de Québec and Laval University</institution>
,<addr-line>Quebec</addr-line>
,<country>Canada</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name>
<affiliation><nlm:aff id="af3"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane, QLD 4029</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name>
<affiliation><nlm:aff id="af3"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane, QLD 4029</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name>
<affiliation><nlm:aff id="af3"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane, QLD 4029</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name>
<affiliation><nlm:aff id="af7"><addr-line>Department of Epidemiology</addr-line>
,<institution>University of California Irvine</institution>
,<addr-line>Irvine, CA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ding, Yuan C" sort="Ding, Yuan C" uniqKey="Ding Y" first="Yuan C." last="Ding">Yuan C. Ding</name>
<affiliation><nlm:aff id="af7"><addr-line>Department of Epidemiology</addr-line>
,<institution>University of California Irvine</institution>
,<addr-line>Irvine, CA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name>
<affiliation><nlm:aff id="af8"><addr-line>Mayo Clinic, Rochester, MN</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name>
<affiliation><nlm:aff id="af8"><addr-line>Mayo Clinic, Rochester, MN</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fredericksen, Zachary" sort="Fredericksen, Zachary" uniqKey="Fredericksen Z" first="Zachary" last="Fredericksen">Zachary Fredericksen</name>
<affiliation><nlm:aff id="af8"><addr-line>Mayo Clinic, Rochester, MN</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name>
<affiliation><nlm:aff id="af9"><institution>Fondazione IRCCS Istituto Nazionale Tumori</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af10"><institution>Fondazione Istituto FIRC di Oncologia Molecolare</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name>
<affiliation><nlm:aff id="af9"><institution>Fondazione IRCCS Istituto Nazionale Tumori</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name>
<affiliation><nlm:aff id="af11"><institution>Istituto Europeo di Oncologia</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Viel, Alessandra" sort="Viel, Alessandra" uniqKey="Viel A" first="Alessandra" last="Viel">Alessandra Viel</name>
<affiliation><nlm:aff id="af12"><addr-line>Centro di Riferimento Oncologico</addr-line>
,<institution>IRCCS</institution>
,<addr-line>Aviano, PN</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bernard, Loris" sort="Bernard, Loris" uniqKey="Bernard L" first="Loris" last="Bernard">Loris Bernard</name>
<affiliation><nlm:aff id="af11"><institution>Istituto Europeo di Oncologia</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af13"><addr-line>Cogentech</addr-line>
,<institution>Consortium for Genomic Technologies</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
<affiliation><nlm:aff id="af9"><institution>Fondazione IRCCS Istituto Nazionale Tumori</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af10"><institution>Fondazione Istituto FIRC di Oncologia Molecolare</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name>
<affiliation><nlm:aff id="af14"><addr-line>Department of Laboratory Medicine and Pathology</addr-line>
,<institution>Mayo Clinic College of Medicine</institution>
,<addr-line>Rochester, MN</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name>
<affiliation><nlm:aff id="af15"><addr-line>Department of Cancer Epidemiology and Genetics</addr-line>
,<institution>Masaryk Memorial Cancer Institute</institution>
,<addr-line>Brno</addr-line>
,<country>Czech Republic</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zikan, Michal" sort="Zikan, Michal" uniqKey="Zikan M" first="Michal" last="Zikan">Michal Zikan</name>
<affiliation><nlm:aff id="af16"><addr-line>Department of Biochemistry and Experimental Oncology, First Faculty of Medicine</addr-line>
,<institution>Charles University</institution>
,<addr-line>Prague</addr-line>
,<country>Czech Republic</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Claes, Kathleen" sort="Claes, Kathleen" uniqKey="Claes K" first="Kathleen" last="Claes">Kathleen Claes</name>
<affiliation><nlm:aff id="af17"><addr-line>Center for Medical Genetics</addr-line>
,<institution>Ghent University Hospital</institution>
,<addr-line>Ghent</addr-line>
,<country>Belgium</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name>
<affiliation><nlm:aff id="af18"><addr-line>Clinical Genetics Branch</addr-line>
,<institution>US National Cancer Institute</institution>
,<addr-line>Rockville, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name>
<affiliation><nlm:aff id="af18"><addr-line>Clinical Genetics Branch</addr-line>
,<institution>US National Cancer Institute</institution>
,<addr-line>Rockville, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name>
<affiliation><nlm:aff id="af19"><addr-line>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology</addr-line>
,<institution>Carmel Medical Center and B. Rappaport Faculty of Medicine</institution>
,<addr-line>Technion, Haifa</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lejbkowicz, Flavio" sort="Lejbkowicz, Flavio" uniqKey="Lejbkowicz F" first="Flavio" last="Lejbkowicz">Flavio Lejbkowicz</name>
<affiliation><nlm:aff id="af19"><addr-line>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology</addr-line>
,<institution>Carmel Medical Center and B. Rappaport Faculty of Medicine</institution>
,<addr-line>Technion, Haifa</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<affiliation><nlm:aff id="af20"><institution>Ontario Cancer Genetics Network, Cancer Care Ontario</institution>
,<addr-line>Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af21"><addr-line>Fred A. Litwin Center for Cancer Genetics</addr-line>
,<institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
,<addr-line>Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af22"><addr-line>Department of Molecular Genetics</addr-line>
,<institution>University of Toronto</institution>
,<addr-line>Toronto, Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ozcelik, Hilmi" sort="Ozcelik, Hilmi" uniqKey="Ozcelik H" first="Hilmi" last="Ozcelik">Hilmi Ozcelik</name>
<affiliation><nlm:aff id="af21"><addr-line>Fred A. Litwin Center for Cancer Genetics</addr-line>
,<institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
,<addr-line>Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name>
<affiliation><nlm:aff id="af20"><institution>Ontario Cancer Genetics Network, Cancer Care Ontario</institution>
,<addr-line>Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name>
<affiliation><nlm:aff id="af23"><addr-line>Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense</addr-line>
,<country>Denmark</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name>
<affiliation><nlm:aff id="af23"><addr-line>Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense</addr-line>
,<country>Denmark</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sunde, Lone" sort="Sunde, Lone" uniqKey="Sunde L" first="Lone" last="Sunde">Lone Sunde</name>
<affiliation><nlm:aff id="af24"><addr-line>Department of Clinical Genetics</addr-line>
,<institution>Aarhus University Hospital</institution>
,<addr-line>Aarhus</addr-line>
,<country>Denmark</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name>
<affiliation><nlm:aff id="af25"><addr-line>Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology</addr-line>
,<institution>University of Pisa and Pisa University Hospital</institution>
,<addr-line>Pisa</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name>
<affiliation><nlm:aff id="af26"><addr-line>The Susanne Levy Gertner Oncogenetics Unit</addr-line>
,<institution>Chaim Sheba Medical Center</institution>
,<addr-line>Tel Hashomer</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kontorovich, Tair" sort="Kontorovich, Tair" uniqKey="Kontorovich T" first="Tair" last="Kontorovich">Tair Kontorovich</name>
<affiliation><nlm:aff id="af26"><addr-line>The Susanne Levy Gertner Oncogenetics Unit</addr-line>
,<institution>Chaim Sheba Medical Center</institution>
,<addr-line>Tel Hashomer</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cohen, Shimrit" sort="Cohen, Shimrit" uniqKey="Cohen S" first="Shimrit" last="Cohen">Shimrit Cohen</name>
<affiliation><nlm:aff id="af26"><addr-line>The Susanne Levy Gertner Oncogenetics Unit</addr-line>
,<institution>Chaim Sheba Medical Center</institution>
,<addr-line>Tel Hashomer</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kaufman, Bella" sort="Kaufman, Bella" uniqKey="Kaufman B" first="Bella" last="Kaufman">Bella Kaufman</name>
<affiliation><nlm:aff id="af27"><institution>The Oncology Institute Chaim Sheba Medical Center</institution>
,<addr-line>Tel Hashomer</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af28"><addr-line>The Sackler School of Medicine</addr-line>
,<institution>Tel-Aviv University</institution>
,<addr-line>Tel-Aviv</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dagan, Efrat" sort="Dagan, Efrat" uniqKey="Dagan E" first="Efrat" last="Dagan">Efrat Dagan</name>
<affiliation><nlm:aff id="af29"><institution>Genetics Institute Rambam Medical Center</institution>
,<addr-line>Haifa</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baruch, Ruth Gershoni" sort="Baruch, Ruth Gershoni" uniqKey="Baruch R" first="Ruth Gershoni" last="Baruch">Ruth Gershoni Baruch</name>
<affiliation><nlm:aff id="af29"><institution>Genetics Institute Rambam Medical Center</institution>
,<addr-line>Haifa</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name>
<affiliation><nlm:aff id="af26"><addr-line>The Susanne Levy Gertner Oncogenetics Unit</addr-line>
,<institution>Chaim Sheba Medical Center</institution>
,<addr-line>Tel Hashomer</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af28"><addr-line>The Sackler School of Medicine</addr-line>
,<institution>Tel-Aviv University</institution>
,<addr-line>Tel-Aviv</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Harbst, Katja" sort="Harbst, Katja" uniqKey="Harbst K" first="Katja" last="Harbst">Katja Harbst</name>
<affiliation><nlm:aff id="af30"><addr-line>Department Oncology</addr-line>
,<institution>Lund University</institution>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Barbany Bustinza, Gisela" sort="Barbany Bustinza, Gisela" uniqKey="Barbany Bustinza G" first="Gisela" last="Barbany-Bustinza">Gisela Barbany-Bustinza</name>
<affiliation><nlm:aff id="af31"><addr-line>Department of Clinical Genetics</addr-line>
,<institution>Karolinska University Hospital</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rantala, Johanna" sort="Rantala, Johanna" uniqKey="Rantala J" first="Johanna" last="Rantala">Johanna Rantala</name>
<affiliation><nlm:aff id="af31"><addr-line>Department of Clinical Genetics</addr-line>
,<institution>Karolinska University Hospital</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name>
<affiliation><nlm:aff id="af32"><addr-line>Department of Genetics and Pathology</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Karlsson, Per" sort="Karlsson, Per" uniqKey="Karlsson P" first="Per" last="Karlsson">Per Karlsson</name>
<affiliation><nlm:aff id="af33"><addr-line>Department of Oncology</addr-line>
,<institution>Sahlgrenska University</institution>
,<addr-line>Gothenburg</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name>
<affiliation><nlm:aff id="af34"><institution>University of Pennsylvania</institution>
,<addr-line>Philadelphia, PA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name>
<affiliation><nlm:aff id="af34"><institution>University of Pennsylvania</institution>
,<addr-line>Philadelphia, PA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name>
<affiliation><nlm:aff id="af35"><addr-line>Group of Human Genetics, Human Cancer Genetics Programme</addr-line>
,<institution>Spanish National Cancer Centre (CNIO) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERERER), Instituto de Salud Carlos III</institution>
,<addr-line>Madrid</addr-line>
,<country>Spain</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name>
<affiliation><nlm:aff id="af36"><addr-line>Cancer Genetics Counseling Program</addr-line>
,<institution>Catalan Institute of Oncology (ICO)</institution>
,<addr-line>Barcelona</addr-line>
,<country>Spain</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lasa, Adriana" sort="Lasa, Adriana" uniqKey="Lasa A" first="Adriana" last="Lasa">Adriana Lasa</name>
<affiliation><nlm:aff id="af37"><addr-line>Genetics Service</addr-line>
,<institution>Hospital de la Santa Creu i Sant Pau</institution>
,<addr-line>Barcelona</addr-line>
,<country>Spain</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name>
<affiliation><nlm:aff id="af35"><addr-line>Group of Human Genetics, Human Cancer Genetics Programme</addr-line>
,<institution>Spanish National Cancer Centre (CNIO) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERERER), Instituto de Salud Carlos III</institution>
,<addr-line>Madrid</addr-line>
,<country>Spain</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation><nlm:aff id="af38"><addr-line>Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580 69120, Heidelberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name>
<affiliation><nlm:aff id="af39"><addr-line>Family Cancer Clinic, Department of Pathology</addr-line>
,<institution>The Netherlands Cancer Institute</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A." last="Rookus">Matti A. Rookus</name>
<affiliation><nlm:aff id="af40"><addr-line>Department of Epidemiology</addr-line>
,<institution>The Netherlands Cancer Institute</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J. Margriet" last="Collee">J. Margriet Collee</name>
<affiliation><nlm:aff id="af41"><addr-line>Department of Clinical Genetics, Rotterdam Family Cancer Clinic</addr-line>
,<institution>Erasmus University Medical Center</institution>
,<addr-line>Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<affiliation><nlm:aff wicri:cut=" and" id="af42"><addr-line>Department of Genetic Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ligtenberg, Marjolijn J" sort="Ligtenberg, Marjolijn J" uniqKey="Ligtenberg M" first="Marjolijn J." last="Ligtenberg">Marjolijn J. Ligtenberg</name>
<affiliation><nlm:aff id="af44"><addr-line>Department of Human Genetics</addr-line>
,<institution>Radboud University Medical Center</institution>
,<addr-line>Nijmegen</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B." last="Van Der Luijt">Rob B. Van Der Luijt</name>
<affiliation><nlm:aff id="af45"><addr-line>Department of Clinical Molecular Genetics</addr-line>
,<institution>Utrecht University Medical Center</institution>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aalfs, Cora M" sort="Aalfs, Cora M" uniqKey="Aalfs C" first="Cora M." last="Aalfs">Cora M. Aalfs</name>
<affiliation><nlm:aff id="af46"><addr-line>Department of Clinical Genetics</addr-line>
,<institution>Academic Medical Center</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Waisfisz, Quinten" sort="Waisfisz, Quinten" uniqKey="Waisfisz Q" first="Quinten" last="Waisfisz">Quinten Waisfisz</name>
<affiliation><nlm:aff id="af47"><addr-line>Department of Clinical Genetics</addr-line>
,<institution>VU University Medical Center</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wijnen, Juul" sort="Wijnen, Juul" uniqKey="Wijnen J" first="Juul" last="Wijnen">Juul Wijnen</name>
<affiliation><nlm:aff id="af43"><addr-line>Center for Human and Clinical Genetics</addr-line>
,<institution>Leiden University Medical Center</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Roozendaal, Cornelis E P" sort="Van Roozendaal, Cornelis E P" uniqKey="Van Roozendaal C" first="Cornelis E. P." last="Van Roozendaal">Cornelis E. P. Van Roozendaal</name>
<affiliation><nlm:aff id="af48"><addr-line>Department of Clinical Genetics</addr-line>
,<institution>University Medical Center</institution>
,<addr-line>Maastricht</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cook, Margaret" sort="Cook, Margaret" uniqKey="Cook M" first="Margaret" last="Cook">Margaret Cook</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Oliver, Clare" sort="Oliver, Clare" uniqKey="Oliver C" first="Clare" last="Oliver">Clare Oliver</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name>
<affiliation><nlm:aff id="af50"><addr-line>Genetic Medicine, Manchester Academic Health Sciences Centre</addr-line>
,<institution>Central Manchester University Hospitals NHS Foundation Trust</institution>
,<addr-line>Manchester</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lalloo, Fiona" sort="Lalloo, Fiona" uniqKey="Lalloo F" first="Fiona" last="Lalloo">Fiona Lalloo</name>
<affiliation><nlm:aff id="af50"><addr-line>Genetic Medicine, Manchester Academic Health Sciences Centre</addr-line>
,<institution>Central Manchester University Hospitals NHS Foundation Trust</institution>
,<addr-line>Manchester</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eeles, Rosalind" sort="Eeles, Rosalind" uniqKey="Eeles R" first="Rosalind" last="Eeles">Rosalind Eeles</name>
<affiliation><nlm:aff id="af51"><addr-line>Translational Cancer Genetics Team</addr-line>
,<institution>The Institute of Cancer Research and Royal Marsden NHS Foundation Trust</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name>
<affiliation><nlm:aff id="af52"><institution>Clinical Genetics, Guy's Hospital</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Davidson, Rosemarie" sort="Davidson, Rosemarie" uniqKey="Davidson R" first="Rosemarie" last="Davidson">Rosemarie Davidson</name>
<affiliation><nlm:aff id="af53"><institution>Ferguson-Smith Centre for Clinical Genetics</institution>
,<addr-line>Glasgow</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chu, Carol" sort="Chu, Carol" uniqKey="Chu C" first="Carol" last="Chu">Carol Chu</name>
<affiliation><nlm:aff id="af54"><institution>Yorkshire Regional Genetics Service</institution>
,<addr-line>Leeds</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name>
<affiliation><nlm:aff id="af55"><addr-line>Wessex Clinical Genetics Service</addr-line>
,<institution>Princess Anne Hospital</institution>
,<addr-line>Southampton</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cole, Trevor" sort="Cole, Trevor" uniqKey="Cole T" first="Trevor" last="Cole">Trevor Cole</name>
<affiliation><nlm:aff id="af56"><addr-line>West Midlands Regional Genetics Service</addr-line>
,<institution>Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston</institution>
,<addr-line>Birmingham</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hodgson, Shirley" sort="Hodgson, Shirley" uniqKey="Hodgson S" first="Shirley" last="Hodgson">Shirley Hodgson</name>
<affiliation><nlm:aff id="af57"><addr-line>Department of Cancer Genetics</addr-line>
,<institution>St Georges Hospital, University of London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name>
<affiliation><nlm:aff id="af58"><institution>Fox Chase Cancer Center</institution>
,<addr-line>Philadelphia, PA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name>
<affiliation><nlm:aff id="af59"><addr-line>INSERM U509, Service de Génétique Oncologique</addr-line>
,<institution>Institut Curie, and Université Paris-Descartes</institution>
,<addr-line>Paris</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Buecher, Bruno" sort="Buecher, Bruno" uniqKey="Buecher B" first="Bruno" last="Buecher">Bruno Buecher</name>
<affiliation><nlm:aff id="af60"><addr-line>Département de Génétique</addr-line>
,<institution>Institut Curie</institution>
,<addr-line>Paris</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Leone, Melanie" sort="Leone, Melanie" uniqKey="Leone M" first="Mélanie" last="Léoné">Mélanie Léoné</name>
<affiliation><nlm:aff id="af2"><addr-line>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents</addr-line>
,<institution>Hospices Civils de Lyon/Centre Léon Bérard, UMR5201 CNRS, Université de Lyon</institution>
,<addr-line>Lyon</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bressac De Paillerets, Brigitte" sort="Bressac De Paillerets, Brigitte" uniqKey="Bressac De Paillerets B" first="Brigitte" last="Bressac-De Paillerets">Brigitte Bressac-De Paillerets</name>
<affiliation><nlm:aff id="af61"><addr-line>Genetics Department</addr-line>
,<institution>Institut de Cancérologie Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af62"><addr-line>INSERM U946</addr-line>
,<institution>Institut de Cancérologie Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Remenieras, Audrey" sort="Remenieras, Audrey" uniqKey="Remenieras A" first="Audrey" last="Remenieras">Audrey Remenieras</name>
<affiliation><nlm:aff id="af61"><addr-line>Genetics Department</addr-line>
,<institution>Institut de Cancérologie Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Caron, Olivier" sort="Caron, Olivier" uniqKey="Caron O" first="Olivier" last="Caron">Olivier Caron</name>
<affiliation><nlm:aff id="af63"><addr-line>Consultation de Génétique, Département de Médecine</addr-line>
,<institution>Institut de Cancérologie Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lenoir, Gilbert M" sort="Lenoir, Gilbert M" uniqKey="Lenoir G" first="Gilbert M." last="Lenoir">Gilbert M. Lenoir</name>
<affiliation><nlm:aff id="af61"><addr-line>Genetics Department</addr-line>
,<institution>Institut de Cancérologie Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af64"><addr-line>CNRS FRE2939</addr-line>
,<institution>Institut de Cancérologie Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sevenet, Nicolas" sort="Sevenet, Nicolas" uniqKey="Sevenet N" first="Nicolas" last="Sevenet">Nicolas Sevenet</name>
<affiliation><nlm:aff id="af65"><addr-line>Laboratoire de Génétique Constitutionnelle</addr-line>
,<institution>Institut Bergonié</institution>
,<addr-line>Bordeaux</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Longy, Michel" sort="Longy, Michel" uniqKey="Longy M" first="Michel" last="Longy">Michel Longy</name>
<affiliation><nlm:aff id="af65"><addr-line>Laboratoire de Génétique Constitutionnelle</addr-line>
,<institution>Institut Bergonié</institution>
,<addr-line>Bordeaux</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af66"><addr-line>INSERM U916</addr-line>
,<institution>Institut Bergonié</institution>
,<addr-line>Bordeaux</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ferrer, Sandra Fert" sort="Ferrer, Sandra Fert" uniqKey="Ferrer S" first="Sandra Fert" last="Ferrer">Sandra Fert Ferrer</name>
<affiliation><nlm:aff id="af67"><addr-line>Laboratoire de Génétique Chromosomique</addr-line>
,<institution>Hôtel Dieu Centre Hospitalier</institution>
,<addr-line>Chambéry</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Prieur, Fabienne" sort="Prieur, Fabienne" uniqKey="Prieur F" first="Fabienne" last="Prieur">Fabienne Prieur</name>
<affiliation><nlm:aff id="af68"><addr-line>Service de Génétique Clinique Chromosomique et Moléculaire</addr-line>
,<institution>CHU de St Etienne</institution>
,<addr-line>St Etienne</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Goldgar, David" sort="Goldgar, David" uniqKey="Goldgar D" first="David" last="Goldgar">David Goldgar</name>
<affiliation><nlm:aff id="af69"><addr-line>Department of Dermatology</addr-line>
,<institution>University of Utah</institution>
,<addr-line>Utah</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name>
<affiliation><nlm:aff id="af70"><institution>Dana-Farber Cancer Institute</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name>
<affiliation><nlm:aff id="af71"><addr-line>Northern California Cancer Center</addr-line>
,<institution>Fremont and Stanford University School of Medicine</institution>
,<addr-line>Stanford, CA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name>
<affiliation><nlm:aff id="af72"><institution>Huntsman Cancer Institute, University of Utah Health Sciences Centre</institution>
,<addr-line>Salt Lake City, UT</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name>
<affiliation><nlm:aff id="af58"><institution>Fox Chase Cancer Center</institution>
,<addr-line>Philadelphia, PA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation><nlm:aff id="af73"><institution>The University of Melbourne</institution>
,<addr-line>Melbourne</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary Beth" last="Terry">Mary Beth Terry</name>
<affiliation><nlm:aff id="af74"><institution>Columbia University</institution>
,<addr-line>New York, NY</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yassin, Yosuf" sort="Yassin, Yosuf" uniqKey="Yassin Y" first="Yosuf" last="Yassin">Yosuf Yassin</name>
<affiliation><nlm:aff id="af70"><institution>Dana-Farber Cancer Institute</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gschwantler Kaulich, Daphne" sort="Gschwantler Kaulich, Daphne" uniqKey="Gschwantler Kaulich D" first="Daphne" last="Gschwantler-Kaulich">Daphne Gschwantler-Kaulich</name>
<affiliation><nlm:aff id="af75"><addr-line>Division of Special Gynecology, Department of OB/GYN</addr-line>
,<institution>Medical University of Vienna</institution>
,<addr-line>Vienna</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Staudigl, Christine" sort="Staudigl, Christine" uniqKey="Staudigl C" first="Christine" last="Staudigl">Christine Staudigl</name>
<affiliation><nlm:aff id="af75"><addr-line>Division of Special Gynecology, Department of OB/GYN</addr-line>
,<institution>Medical University of Vienna</institution>
,<addr-line>Vienna</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V. O." last="Hansen">Thomas V. O. Hansen</name>
<affiliation><nlm:aff id="af76"><addr-line>Department of Clinical Biochemistry, Rigshospitalet</addr-line>
,<institution>University of Copenhagen</institution>
,<addr-line>Copenhagen</addr-line>
,<country>Denmark</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Barkardottir, Rosa Bjork" sort="Barkardottir, Rosa Bjork" uniqKey="Barkardottir R" first="Rosa Bjork" last="Barkardottir">Rosa Bjork Barkardottir</name>
<affiliation><nlm:aff id="af77"><addr-line>Department of Pathology</addr-line>
,<institution>Landspitali-University Hospital</institution>
,<addr-line>Reykjavik</addr-line>
,<country>Iceland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kirchhoff, Tomas" sort="Kirchhoff, Tomas" uniqKey="Kirchhoff T" first="Tomas" last="Kirchhoff">Tomas Kirchhoff</name>
<affiliation><nlm:aff id="af78"><addr-line>Clinical Genetics Service, Department of Medicine</addr-line>
,<institution>Memorial Sloan-Kettering Cancer Center</institution>
,<addr-line>New York, NY</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pal, Prodipto" sort="Pal, Prodipto" uniqKey="Pal P" first="Prodipto" last="Pal">Prodipto Pal</name>
<affiliation><nlm:aff id="af78"><addr-line>Clinical Genetics Service, Department of Medicine</addr-line>
,<institution>Memorial Sloan-Kettering Cancer Center</institution>
,<addr-line>New York, NY</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kosarin, Kristi" sort="Kosarin, Kristi" uniqKey="Kosarin K" first="Kristi" last="Kosarin">Kristi Kosarin</name>
<affiliation><nlm:aff id="af78"><addr-line>Clinical Genetics Service, Department of Medicine</addr-line>
,<institution>Memorial Sloan-Kettering Cancer Center</institution>
,<addr-line>New York, NY</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name>
<affiliation><nlm:aff id="af78"><addr-line>Clinical Genetics Service, Department of Medicine</addr-line>
,<institution>Memorial Sloan-Kettering Cancer Center</institution>
,<addr-line>New York, NY</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name>
<affiliation><nlm:aff id="af79"><addr-line>GOG Statistical and Data Center</addr-line>
,<institution>Roswell Park Cancer Institute</institution>
,<addr-line>Buffalo, NY 14263</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Gustavo C" sort="Rodriguez, Gustavo C" uniqKey="Rodriguez G" first="Gustavo C." last="Rodriguez">Gustavo C. Rodriguez</name>
<affiliation><nlm:aff id="af80"><institution>NorthShore University Health System, Evanston Northwestern Healthcare</institution>
,<addr-line>Evanston IL 60201</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wakeley, Katie" sort="Wakeley, Katie" uniqKey="Wakeley K" first="Katie" last="Wakeley">Katie Wakeley</name>
<affiliation><nlm:aff id="af81"><institution>New England Medical Center, Tufts University</institution>
,<addr-line>Boston, MA 02111</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Boggess, John F" sort="Boggess, John F" uniqKey="Boggess J" first="John F." last="Boggess">John F. Boggess</name>
<affiliation><nlm:aff id="af82"><institution>University of North Carolina</institution>
,<addr-line>Chapel Hill, NC 27599</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Basil, Jack" sort="Basil, Jack" uniqKey="Basil J" first="Jack" last="Basil">Jack Basil</name>
<affiliation><nlm:aff id="af83"><institution>St Elizabeth Medical Center</institution>
,<addr-line>Edgewood, KY 41017</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schwartz, Peter E" sort="Schwartz, Peter E" uniqKey="Schwartz P" first="Peter E." last="Schwartz">Peter E. Schwartz</name>
<affiliation><nlm:aff id="af84"><institution>Yale University School of Medicine</institution>
,<addr-line>New Haven, CT 06510</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Blank, Stephanie V" sort="Blank, Stephanie V" uniqKey="Blank S" first="Stephanie V." last="Blank">Stephanie V. Blank</name>
<affiliation><nlm:aff id="af85"><institution>New York University School of Medicine</institution>
,<addr-line>New York, NY 10016</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name>
<affiliation><nlm:aff wicri:cut=" and" id="af86"><addr-line>Department of Internal Medicine</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af87"><addr-line>Molecular Virology</addr-line>
,<institution>Immunology and Medical Genetics, Division of Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University</institution>
,<addr-line>Columbus, OH 43210</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name>
<affiliation><nlm:aff id="af88"><institution>Istituto Oncologico Veneto, IRCCS, Immunology and Molecular Oncology Unit</institution>
,<addr-line>Padua</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Casella, Cinzia" sort="Casella, Cinzia" uniqKey="Casella C" first="Cinzia" last="Casella">Cinzia Casella</name>
<affiliation><nlm:aff id="af88"><institution>Istituto Oncologico Veneto, IRCCS, Immunology and Molecular Oncology Unit</institution>
,<addr-line>Padua</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N." last="Imyanitov">Evgeny N. Imyanitov</name>
<affiliation><nlm:aff id="af89"><institution>N.N. Petrov Institute of Oncology</institution>
,<addr-line>St Petersburg</addr-line>
,<country>Russia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Allavena, Anna" sort="Allavena, Anna" uniqKey="Allavena A" first="Anna" last="Allavena">Anna Allavena</name>
<affiliation><nlm:aff id="af90"><addr-line>Department of Genetics, Biology and Biochemistry</addr-line>
,<institution>University of Turin</institution>
,<addr-line>Turin</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name>
<affiliation><nlm:aff id="af91"><addr-line>Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology</addr-line>
,<institution>University of Cologne</institution>
,<addr-line>Cologne</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Versmold, Beatrix" sort="Versmold, Beatrix" uniqKey="Versmold B" first="Beatrix" last="Versmold">Beatrix Versmold</name>
<affiliation><nlm:aff id="af91"><addr-line>Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology</addr-line>
,<institution>University of Cologne</institution>
,<addr-line>Cologne</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name>
<affiliation><nlm:aff id="af92"><institution>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig</institution>
,<addr-line>Leipzig</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation><nlm:aff id="af93"><addr-line>Department of Obstetrics and Gynaecology</addr-line>
,<institution>Technical University Munich</institution>
,<addr-line>Munich</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ditsch, Nina" sort="Ditsch, Nina" uniqKey="Ditsch N" first="Nina" last="Ditsch">Nina Ditsch</name>
<affiliation><nlm:aff id="af94"><addr-line>Department of Obstetrics and Gynecology</addr-line>
,<institution>Ludwig-Maximilian University Munich</institution>
,<addr-line>Munich</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name>
<affiliation><nlm:aff id="af96"><addr-line>Molecular Genetics Laboratory, Department of Obstetrics and Gynaecology</addr-line>
,<institution>University of Duesseldorf</institution>
,<addr-line>Duesseldorf</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name>
<affiliation><nlm:aff id="af96"><addr-line>Molecular Genetics Laboratory, Department of Obstetrics and Gynaecology</addr-line>
,<institution>University of Duesseldorf</institution>
,<addr-line>Duesseldorf</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dei Ler, Helmut" sort="Dei Ler, Helmut" uniqKey="Dei Ler H" first="Helmut" last="Dei Ler">Helmut Dei Ler</name>
<affiliation><nlm:aff id="af97"><addr-line>Department of Obstetrics and Gynaecology</addr-line>
,<institution>University of Ulm</institution>
,<addr-line>Ulm</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fiebig, Britta" sort="Fiebig, Britta" uniqKey="Fiebig B" first="Britta" last="Fiebig">Britta Fiebig</name>
<affiliation><nlm:aff id="af98"><institution>Institute of Human Genetics, University of Regensburg</institution>
,<addr-line>Regensburg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Suttner, Christian" sort="Suttner, Christian" uniqKey="Suttner C" first="Christian" last="Suttner">Christian Suttner</name>
<affiliation><nlm:aff id="af99"><institution>Institute of Human Genetics, University of Heidelberg</institution>
,<addr-line>Heidelberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schonbuchner, Ines" sort="Schonbuchner, Ines" uniqKey="Schonbuchner I" first="Ines" last="Schönbuchner">Ines Schönbuchner</name>
<affiliation><nlm:aff id="af100"><institution>Institute of Human Genetics, University of Würzburg, Würzburg</institution>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gadzicki, Dorothea" sort="Gadzicki, Dorothea" uniqKey="Gadzicki D" first="Dorothea" last="Gadzicki">Dorothea Gadzicki</name>
<affiliation><nlm:aff wicri:cut=" and" id="af101"><institution>Institute of Cellular and Molecular Pathology, Medical University</institution>
,<addr-line>Hannover</addr-line>
,<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name>
<affiliation><nlm:aff id="af102"><institution>Hospital Clinico San Carlos</institution>
<addr-line>28040, Madrid</addr-line>
,<country>Spain</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name>
<affiliation><nlm:aff id="af102"><institution>Hospital Clinico San Carlos</institution>
<addr-line>28040, Madrid</addr-line>
,<country>Spain</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation><nlm:aff id="af3"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane, QLD 4029</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19656774</idno>
<idno type="pmc">2782243</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782243</idno>
<idno type="RBID">PMC:2782243</idno>
<idno type="doi">10.1093/hmg/ddp372</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">001879</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001879</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common variants in <italic>LSP1</italic>
, 2q35 and 8q24 and breast cancer risk for <italic>BRCA1</italic>
and <italic>BRCA2</italic>
mutation carriers</title>
<author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name>
<affiliation><nlm:aff id="af2"><addr-line>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents</addr-line>
,<institution>Hospices Civils de Lyon/Centre Léon Bérard, UMR5201 CNRS, Université de Lyon</institution>
,<addr-line>Lyon</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name>
<affiliation><nlm:aff id="af3"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane, QLD 4029</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation><nlm:aff id="af4"><addr-line>Department of Obstetrics and Gynecology</addr-line>
,<institution>Helsinki University Central Hospital</institution>
,<addr-line>Helsinki</addr-line>
,<country>Finland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Heikkinen, Tuomas" sort="Heikkinen, Tuomas" uniqKey="Heikkinen T" first="Tuomas" last="Heikkinen">Tuomas Heikkinen</name>
<affiliation><nlm:aff id="af4"><addr-line>Department of Obstetrics and Gynecology</addr-line>
,<institution>Helsinki University Central Hospital</institution>
,<addr-line>Helsinki</addr-line>
,<country>Finland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<affiliation><nlm:aff id="af5"><addr-line>Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory</addr-line>
,<institution>Centre Hospitalier Universitaire de Québec and Laval University</institution>
,<addr-line>Quebec</addr-line>
,<country>Canada</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name>
<affiliation><nlm:aff id="af3"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane, QLD 4029</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name>
<affiliation><nlm:aff id="af3"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane, QLD 4029</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name>
<affiliation><nlm:aff id="af3"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane, QLD 4029</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name>
<affiliation><nlm:aff id="af7"><addr-line>Department of Epidemiology</addr-line>
,<institution>University of California Irvine</institution>
,<addr-line>Irvine, CA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ding, Yuan C" sort="Ding, Yuan C" uniqKey="Ding Y" first="Yuan C." last="Ding">Yuan C. Ding</name>
<affiliation><nlm:aff id="af7"><addr-line>Department of Epidemiology</addr-line>
,<institution>University of California Irvine</institution>
,<addr-line>Irvine, CA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name>
<affiliation><nlm:aff id="af8"><addr-line>Mayo Clinic, Rochester, MN</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name>
<affiliation><nlm:aff id="af8"><addr-line>Mayo Clinic, Rochester, MN</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fredericksen, Zachary" sort="Fredericksen, Zachary" uniqKey="Fredericksen Z" first="Zachary" last="Fredericksen">Zachary Fredericksen</name>
<affiliation><nlm:aff id="af8"><addr-line>Mayo Clinic, Rochester, MN</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name>
<affiliation><nlm:aff id="af9"><institution>Fondazione IRCCS Istituto Nazionale Tumori</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af10"><institution>Fondazione Istituto FIRC di Oncologia Molecolare</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name>
<affiliation><nlm:aff id="af9"><institution>Fondazione IRCCS Istituto Nazionale Tumori</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name>
<affiliation><nlm:aff id="af11"><institution>Istituto Europeo di Oncologia</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Viel, Alessandra" sort="Viel, Alessandra" uniqKey="Viel A" first="Alessandra" last="Viel">Alessandra Viel</name>
<affiliation><nlm:aff id="af12"><addr-line>Centro di Riferimento Oncologico</addr-line>
,<institution>IRCCS</institution>
,<addr-line>Aviano, PN</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bernard, Loris" sort="Bernard, Loris" uniqKey="Bernard L" first="Loris" last="Bernard">Loris Bernard</name>
<affiliation><nlm:aff id="af11"><institution>Istituto Europeo di Oncologia</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af13"><addr-line>Cogentech</addr-line>
,<institution>Consortium for Genomic Technologies</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
<affiliation><nlm:aff id="af9"><institution>Fondazione IRCCS Istituto Nazionale Tumori</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af10"><institution>Fondazione Istituto FIRC di Oncologia Molecolare</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name>
<affiliation><nlm:aff id="af14"><addr-line>Department of Laboratory Medicine and Pathology</addr-line>
,<institution>Mayo Clinic College of Medicine</institution>
,<addr-line>Rochester, MN</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name>
<affiliation><nlm:aff id="af15"><addr-line>Department of Cancer Epidemiology and Genetics</addr-line>
,<institution>Masaryk Memorial Cancer Institute</institution>
,<addr-line>Brno</addr-line>
,<country>Czech Republic</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zikan, Michal" sort="Zikan, Michal" uniqKey="Zikan M" first="Michal" last="Zikan">Michal Zikan</name>
<affiliation><nlm:aff id="af16"><addr-line>Department of Biochemistry and Experimental Oncology, First Faculty of Medicine</addr-line>
,<institution>Charles University</institution>
,<addr-line>Prague</addr-line>
,<country>Czech Republic</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Claes, Kathleen" sort="Claes, Kathleen" uniqKey="Claes K" first="Kathleen" last="Claes">Kathleen Claes</name>
<affiliation><nlm:aff id="af17"><addr-line>Center for Medical Genetics</addr-line>
,<institution>Ghent University Hospital</institution>
,<addr-line>Ghent</addr-line>
,<country>Belgium</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name>
<affiliation><nlm:aff id="af18"><addr-line>Clinical Genetics Branch</addr-line>
,<institution>US National Cancer Institute</institution>
,<addr-line>Rockville, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name>
<affiliation><nlm:aff id="af18"><addr-line>Clinical Genetics Branch</addr-line>
,<institution>US National Cancer Institute</institution>
,<addr-line>Rockville, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name>
<affiliation><nlm:aff id="af19"><addr-line>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology</addr-line>
,<institution>Carmel Medical Center and B. Rappaport Faculty of Medicine</institution>
,<addr-line>Technion, Haifa</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lejbkowicz, Flavio" sort="Lejbkowicz, Flavio" uniqKey="Lejbkowicz F" first="Flavio" last="Lejbkowicz">Flavio Lejbkowicz</name>
<affiliation><nlm:aff id="af19"><addr-line>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology</addr-line>
,<institution>Carmel Medical Center and B. Rappaport Faculty of Medicine</institution>
,<addr-line>Technion, Haifa</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<affiliation><nlm:aff id="af20"><institution>Ontario Cancer Genetics Network, Cancer Care Ontario</institution>
,<addr-line>Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af21"><addr-line>Fred A. Litwin Center for Cancer Genetics</addr-line>
,<institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
,<addr-line>Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af22"><addr-line>Department of Molecular Genetics</addr-line>
,<institution>University of Toronto</institution>
,<addr-line>Toronto, Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ozcelik, Hilmi" sort="Ozcelik, Hilmi" uniqKey="Ozcelik H" first="Hilmi" last="Ozcelik">Hilmi Ozcelik</name>
<affiliation><nlm:aff id="af21"><addr-line>Fred A. Litwin Center for Cancer Genetics</addr-line>
,<institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
,<addr-line>Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name>
<affiliation><nlm:aff id="af20"><institution>Ontario Cancer Genetics Network, Cancer Care Ontario</institution>
,<addr-line>Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name>
<affiliation><nlm:aff id="af23"><addr-line>Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense</addr-line>
,<country>Denmark</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name>
<affiliation><nlm:aff id="af23"><addr-line>Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense</addr-line>
,<country>Denmark</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sunde, Lone" sort="Sunde, Lone" uniqKey="Sunde L" first="Lone" last="Sunde">Lone Sunde</name>
<affiliation><nlm:aff id="af24"><addr-line>Department of Clinical Genetics</addr-line>
,<institution>Aarhus University Hospital</institution>
,<addr-line>Aarhus</addr-line>
,<country>Denmark</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name>
<affiliation><nlm:aff id="af25"><addr-line>Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology</addr-line>
,<institution>University of Pisa and Pisa University Hospital</institution>
,<addr-line>Pisa</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name>
<affiliation><nlm:aff id="af26"><addr-line>The Susanne Levy Gertner Oncogenetics Unit</addr-line>
,<institution>Chaim Sheba Medical Center</institution>
,<addr-line>Tel Hashomer</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kontorovich, Tair" sort="Kontorovich, Tair" uniqKey="Kontorovich T" first="Tair" last="Kontorovich">Tair Kontorovich</name>
<affiliation><nlm:aff id="af26"><addr-line>The Susanne Levy Gertner Oncogenetics Unit</addr-line>
,<institution>Chaim Sheba Medical Center</institution>
,<addr-line>Tel Hashomer</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cohen, Shimrit" sort="Cohen, Shimrit" uniqKey="Cohen S" first="Shimrit" last="Cohen">Shimrit Cohen</name>
<affiliation><nlm:aff id="af26"><addr-line>The Susanne Levy Gertner Oncogenetics Unit</addr-line>
,<institution>Chaim Sheba Medical Center</institution>
,<addr-line>Tel Hashomer</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kaufman, Bella" sort="Kaufman, Bella" uniqKey="Kaufman B" first="Bella" last="Kaufman">Bella Kaufman</name>
<affiliation><nlm:aff id="af27"><institution>The Oncology Institute Chaim Sheba Medical Center</institution>
,<addr-line>Tel Hashomer</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af28"><addr-line>The Sackler School of Medicine</addr-line>
,<institution>Tel-Aviv University</institution>
,<addr-line>Tel-Aviv</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dagan, Efrat" sort="Dagan, Efrat" uniqKey="Dagan E" first="Efrat" last="Dagan">Efrat Dagan</name>
<affiliation><nlm:aff id="af29"><institution>Genetics Institute Rambam Medical Center</institution>
,<addr-line>Haifa</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baruch, Ruth Gershoni" sort="Baruch, Ruth Gershoni" uniqKey="Baruch R" first="Ruth Gershoni" last="Baruch">Ruth Gershoni Baruch</name>
<affiliation><nlm:aff id="af29"><institution>Genetics Institute Rambam Medical Center</institution>
,<addr-line>Haifa</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name>
<affiliation><nlm:aff id="af26"><addr-line>The Susanne Levy Gertner Oncogenetics Unit</addr-line>
,<institution>Chaim Sheba Medical Center</institution>
,<addr-line>Tel Hashomer</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af28"><addr-line>The Sackler School of Medicine</addr-line>
,<institution>Tel-Aviv University</institution>
,<addr-line>Tel-Aviv</addr-line>
,<country>Israel</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Harbst, Katja" sort="Harbst, Katja" uniqKey="Harbst K" first="Katja" last="Harbst">Katja Harbst</name>
<affiliation><nlm:aff id="af30"><addr-line>Department Oncology</addr-line>
,<institution>Lund University</institution>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Barbany Bustinza, Gisela" sort="Barbany Bustinza, Gisela" uniqKey="Barbany Bustinza G" first="Gisela" last="Barbany-Bustinza">Gisela Barbany-Bustinza</name>
<affiliation><nlm:aff id="af31"><addr-line>Department of Clinical Genetics</addr-line>
,<institution>Karolinska University Hospital</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rantala, Johanna" sort="Rantala, Johanna" uniqKey="Rantala J" first="Johanna" last="Rantala">Johanna Rantala</name>
<affiliation><nlm:aff id="af31"><addr-line>Department of Clinical Genetics</addr-line>
,<institution>Karolinska University Hospital</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name>
<affiliation><nlm:aff id="af32"><addr-line>Department of Genetics and Pathology</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Karlsson, Per" sort="Karlsson, Per" uniqKey="Karlsson P" first="Per" last="Karlsson">Per Karlsson</name>
<affiliation><nlm:aff id="af33"><addr-line>Department of Oncology</addr-line>
,<institution>Sahlgrenska University</institution>
,<addr-line>Gothenburg</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name>
<affiliation><nlm:aff id="af34"><institution>University of Pennsylvania</institution>
,<addr-line>Philadelphia, PA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name>
<affiliation><nlm:aff id="af34"><institution>University of Pennsylvania</institution>
,<addr-line>Philadelphia, PA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name>
<affiliation><nlm:aff id="af35"><addr-line>Group of Human Genetics, Human Cancer Genetics Programme</addr-line>
,<institution>Spanish National Cancer Centre (CNIO) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERERER), Instituto de Salud Carlos III</institution>
,<addr-line>Madrid</addr-line>
,<country>Spain</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name>
<affiliation><nlm:aff id="af36"><addr-line>Cancer Genetics Counseling Program</addr-line>
,<institution>Catalan Institute of Oncology (ICO)</institution>
,<addr-line>Barcelona</addr-line>
,<country>Spain</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lasa, Adriana" sort="Lasa, Adriana" uniqKey="Lasa A" first="Adriana" last="Lasa">Adriana Lasa</name>
<affiliation><nlm:aff id="af37"><addr-line>Genetics Service</addr-line>
,<institution>Hospital de la Santa Creu i Sant Pau</institution>
,<addr-line>Barcelona</addr-line>
,<country>Spain</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name>
<affiliation><nlm:aff id="af35"><addr-line>Group of Human Genetics, Human Cancer Genetics Programme</addr-line>
,<institution>Spanish National Cancer Centre (CNIO) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERERER), Instituto de Salud Carlos III</institution>
,<addr-line>Madrid</addr-line>
,<country>Spain</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation><nlm:aff id="af38"><addr-line>Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580 69120, Heidelberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name>
<affiliation><nlm:aff id="af39"><addr-line>Family Cancer Clinic, Department of Pathology</addr-line>
,<institution>The Netherlands Cancer Institute</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A." last="Rookus">Matti A. Rookus</name>
<affiliation><nlm:aff id="af40"><addr-line>Department of Epidemiology</addr-line>
,<institution>The Netherlands Cancer Institute</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J. Margriet" last="Collee">J. Margriet Collee</name>
<affiliation><nlm:aff id="af41"><addr-line>Department of Clinical Genetics, Rotterdam Family Cancer Clinic</addr-line>
,<institution>Erasmus University Medical Center</institution>
,<addr-line>Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<affiliation><nlm:aff wicri:cut=" and" id="af42"><addr-line>Department of Genetic Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ligtenberg, Marjolijn J" sort="Ligtenberg, Marjolijn J" uniqKey="Ligtenberg M" first="Marjolijn J." last="Ligtenberg">Marjolijn J. Ligtenberg</name>
<affiliation><nlm:aff id="af44"><addr-line>Department of Human Genetics</addr-line>
,<institution>Radboud University Medical Center</institution>
,<addr-line>Nijmegen</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B." last="Van Der Luijt">Rob B. Van Der Luijt</name>
<affiliation><nlm:aff id="af45"><addr-line>Department of Clinical Molecular Genetics</addr-line>
,<institution>Utrecht University Medical Center</institution>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aalfs, Cora M" sort="Aalfs, Cora M" uniqKey="Aalfs C" first="Cora M." last="Aalfs">Cora M. Aalfs</name>
<affiliation><nlm:aff id="af46"><addr-line>Department of Clinical Genetics</addr-line>
,<institution>Academic Medical Center</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Waisfisz, Quinten" sort="Waisfisz, Quinten" uniqKey="Waisfisz Q" first="Quinten" last="Waisfisz">Quinten Waisfisz</name>
<affiliation><nlm:aff id="af47"><addr-line>Department of Clinical Genetics</addr-line>
,<institution>VU University Medical Center</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wijnen, Juul" sort="Wijnen, Juul" uniqKey="Wijnen J" first="Juul" last="Wijnen">Juul Wijnen</name>
<affiliation><nlm:aff id="af43"><addr-line>Center for Human and Clinical Genetics</addr-line>
,<institution>Leiden University Medical Center</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Roozendaal, Cornelis E P" sort="Van Roozendaal, Cornelis E P" uniqKey="Van Roozendaal C" first="Cornelis E. P." last="Van Roozendaal">Cornelis E. P. Van Roozendaal</name>
<affiliation><nlm:aff id="af48"><addr-line>Department of Clinical Genetics</addr-line>
,<institution>University Medical Center</institution>
,<addr-line>Maastricht</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cook, Margaret" sort="Cook, Margaret" uniqKey="Cook M" first="Margaret" last="Cook">Margaret Cook</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Oliver, Clare" sort="Oliver, Clare" uniqKey="Oliver C" first="Clare" last="Oliver">Clare Oliver</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name>
<affiliation><nlm:aff id="af50"><addr-line>Genetic Medicine, Manchester Academic Health Sciences Centre</addr-line>
,<institution>Central Manchester University Hospitals NHS Foundation Trust</institution>
,<addr-line>Manchester</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lalloo, Fiona" sort="Lalloo, Fiona" uniqKey="Lalloo F" first="Fiona" last="Lalloo">Fiona Lalloo</name>
<affiliation><nlm:aff id="af50"><addr-line>Genetic Medicine, Manchester Academic Health Sciences Centre</addr-line>
,<institution>Central Manchester University Hospitals NHS Foundation Trust</institution>
,<addr-line>Manchester</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eeles, Rosalind" sort="Eeles, Rosalind" uniqKey="Eeles R" first="Rosalind" last="Eeles">Rosalind Eeles</name>
<affiliation><nlm:aff id="af51"><addr-line>Translational Cancer Genetics Team</addr-line>
,<institution>The Institute of Cancer Research and Royal Marsden NHS Foundation Trust</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name>
<affiliation><nlm:aff id="af52"><institution>Clinical Genetics, Guy's Hospital</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Davidson, Rosemarie" sort="Davidson, Rosemarie" uniqKey="Davidson R" first="Rosemarie" last="Davidson">Rosemarie Davidson</name>
<affiliation><nlm:aff id="af53"><institution>Ferguson-Smith Centre for Clinical Genetics</institution>
,<addr-line>Glasgow</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chu, Carol" sort="Chu, Carol" uniqKey="Chu C" first="Carol" last="Chu">Carol Chu</name>
<affiliation><nlm:aff id="af54"><institution>Yorkshire Regional Genetics Service</institution>
,<addr-line>Leeds</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name>
<affiliation><nlm:aff id="af55"><addr-line>Wessex Clinical Genetics Service</addr-line>
,<institution>Princess Anne Hospital</institution>
,<addr-line>Southampton</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cole, Trevor" sort="Cole, Trevor" uniqKey="Cole T" first="Trevor" last="Cole">Trevor Cole</name>
<affiliation><nlm:aff id="af56"><addr-line>West Midlands Regional Genetics Service</addr-line>
,<institution>Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston</institution>
,<addr-line>Birmingham</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hodgson, Shirley" sort="Hodgson, Shirley" uniqKey="Hodgson S" first="Shirley" last="Hodgson">Shirley Hodgson</name>
<affiliation><nlm:aff id="af57"><addr-line>Department of Cancer Genetics</addr-line>
,<institution>St Georges Hospital, University of London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name>
<affiliation><nlm:aff id="af58"><institution>Fox Chase Cancer Center</institution>
,<addr-line>Philadelphia, PA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name>
<affiliation><nlm:aff id="af59"><addr-line>INSERM U509, Service de Génétique Oncologique</addr-line>
,<institution>Institut Curie, and Université Paris-Descartes</institution>
,<addr-line>Paris</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Buecher, Bruno" sort="Buecher, Bruno" uniqKey="Buecher B" first="Bruno" last="Buecher">Bruno Buecher</name>
<affiliation><nlm:aff id="af60"><addr-line>Département de Génétique</addr-line>
,<institution>Institut Curie</institution>
,<addr-line>Paris</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Leone, Melanie" sort="Leone, Melanie" uniqKey="Leone M" first="Mélanie" last="Léoné">Mélanie Léoné</name>
<affiliation><nlm:aff id="af2"><addr-line>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents</addr-line>
,<institution>Hospices Civils de Lyon/Centre Léon Bérard, UMR5201 CNRS, Université de Lyon</institution>
,<addr-line>Lyon</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bressac De Paillerets, Brigitte" sort="Bressac De Paillerets, Brigitte" uniqKey="Bressac De Paillerets B" first="Brigitte" last="Bressac-De Paillerets">Brigitte Bressac-De Paillerets</name>
<affiliation><nlm:aff id="af61"><addr-line>Genetics Department</addr-line>
,<institution>Institut de Cancérologie Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af62"><addr-line>INSERM U946</addr-line>
,<institution>Institut de Cancérologie Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Remenieras, Audrey" sort="Remenieras, Audrey" uniqKey="Remenieras A" first="Audrey" last="Remenieras">Audrey Remenieras</name>
<affiliation><nlm:aff id="af61"><addr-line>Genetics Department</addr-line>
,<institution>Institut de Cancérologie Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Caron, Olivier" sort="Caron, Olivier" uniqKey="Caron O" first="Olivier" last="Caron">Olivier Caron</name>
<affiliation><nlm:aff id="af63"><addr-line>Consultation de Génétique, Département de Médecine</addr-line>
,<institution>Institut de Cancérologie Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lenoir, Gilbert M" sort="Lenoir, Gilbert M" uniqKey="Lenoir G" first="Gilbert M." last="Lenoir">Gilbert M. Lenoir</name>
<affiliation><nlm:aff id="af61"><addr-line>Genetics Department</addr-line>
,<institution>Institut de Cancérologie Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af64"><addr-line>CNRS FRE2939</addr-line>
,<institution>Institut de Cancérologie Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sevenet, Nicolas" sort="Sevenet, Nicolas" uniqKey="Sevenet N" first="Nicolas" last="Sevenet">Nicolas Sevenet</name>
<affiliation><nlm:aff id="af65"><addr-line>Laboratoire de Génétique Constitutionnelle</addr-line>
,<institution>Institut Bergonié</institution>
,<addr-line>Bordeaux</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Longy, Michel" sort="Longy, Michel" uniqKey="Longy M" first="Michel" last="Longy">Michel Longy</name>
<affiliation><nlm:aff id="af65"><addr-line>Laboratoire de Génétique Constitutionnelle</addr-line>
,<institution>Institut Bergonié</institution>
,<addr-line>Bordeaux</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af66"><addr-line>INSERM U916</addr-line>
,<institution>Institut Bergonié</institution>
,<addr-line>Bordeaux</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ferrer, Sandra Fert" sort="Ferrer, Sandra Fert" uniqKey="Ferrer S" first="Sandra Fert" last="Ferrer">Sandra Fert Ferrer</name>
<affiliation><nlm:aff id="af67"><addr-line>Laboratoire de Génétique Chromosomique</addr-line>
,<institution>Hôtel Dieu Centre Hospitalier</institution>
,<addr-line>Chambéry</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Prieur, Fabienne" sort="Prieur, Fabienne" uniqKey="Prieur F" first="Fabienne" last="Prieur">Fabienne Prieur</name>
<affiliation><nlm:aff id="af68"><addr-line>Service de Génétique Clinique Chromosomique et Moléculaire</addr-line>
,<institution>CHU de St Etienne</institution>
,<addr-line>St Etienne</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Goldgar, David" sort="Goldgar, David" uniqKey="Goldgar D" first="David" last="Goldgar">David Goldgar</name>
<affiliation><nlm:aff id="af69"><addr-line>Department of Dermatology</addr-line>
,<institution>University of Utah</institution>
,<addr-line>Utah</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name>
<affiliation><nlm:aff id="af70"><institution>Dana-Farber Cancer Institute</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name>
<affiliation><nlm:aff id="af71"><addr-line>Northern California Cancer Center</addr-line>
,<institution>Fremont and Stanford University School of Medicine</institution>
,<addr-line>Stanford, CA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name>
<affiliation><nlm:aff id="af72"><institution>Huntsman Cancer Institute, University of Utah Health Sciences Centre</institution>
,<addr-line>Salt Lake City, UT</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name>
<affiliation><nlm:aff id="af58"><institution>Fox Chase Cancer Center</institution>
,<addr-line>Philadelphia, PA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation><nlm:aff id="af73"><institution>The University of Melbourne</institution>
,<addr-line>Melbourne</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary Beth" last="Terry">Mary Beth Terry</name>
<affiliation><nlm:aff id="af74"><institution>Columbia University</institution>
,<addr-line>New York, NY</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yassin, Yosuf" sort="Yassin, Yosuf" uniqKey="Yassin Y" first="Yosuf" last="Yassin">Yosuf Yassin</name>
<affiliation><nlm:aff id="af70"><institution>Dana-Farber Cancer Institute</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gschwantler Kaulich, Daphne" sort="Gschwantler Kaulich, Daphne" uniqKey="Gschwantler Kaulich D" first="Daphne" last="Gschwantler-Kaulich">Daphne Gschwantler-Kaulich</name>
<affiliation><nlm:aff id="af75"><addr-line>Division of Special Gynecology, Department of OB/GYN</addr-line>
,<institution>Medical University of Vienna</institution>
,<addr-line>Vienna</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Staudigl, Christine" sort="Staudigl, Christine" uniqKey="Staudigl C" first="Christine" last="Staudigl">Christine Staudigl</name>
<affiliation><nlm:aff id="af75"><addr-line>Division of Special Gynecology, Department of OB/GYN</addr-line>
,<institution>Medical University of Vienna</institution>
,<addr-line>Vienna</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V. O." last="Hansen">Thomas V. O. Hansen</name>
<affiliation><nlm:aff id="af76"><addr-line>Department of Clinical Biochemistry, Rigshospitalet</addr-line>
,<institution>University of Copenhagen</institution>
,<addr-line>Copenhagen</addr-line>
,<country>Denmark</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Barkardottir, Rosa Bjork" sort="Barkardottir, Rosa Bjork" uniqKey="Barkardottir R" first="Rosa Bjork" last="Barkardottir">Rosa Bjork Barkardottir</name>
<affiliation><nlm:aff id="af77"><addr-line>Department of Pathology</addr-line>
,<institution>Landspitali-University Hospital</institution>
,<addr-line>Reykjavik</addr-line>
,<country>Iceland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kirchhoff, Tomas" sort="Kirchhoff, Tomas" uniqKey="Kirchhoff T" first="Tomas" last="Kirchhoff">Tomas Kirchhoff</name>
<affiliation><nlm:aff id="af78"><addr-line>Clinical Genetics Service, Department of Medicine</addr-line>
,<institution>Memorial Sloan-Kettering Cancer Center</institution>
,<addr-line>New York, NY</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pal, Prodipto" sort="Pal, Prodipto" uniqKey="Pal P" first="Prodipto" last="Pal">Prodipto Pal</name>
<affiliation><nlm:aff id="af78"><addr-line>Clinical Genetics Service, Department of Medicine</addr-line>
,<institution>Memorial Sloan-Kettering Cancer Center</institution>
,<addr-line>New York, NY</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kosarin, Kristi" sort="Kosarin, Kristi" uniqKey="Kosarin K" first="Kristi" last="Kosarin">Kristi Kosarin</name>
<affiliation><nlm:aff id="af78"><addr-line>Clinical Genetics Service, Department of Medicine</addr-line>
,<institution>Memorial Sloan-Kettering Cancer Center</institution>
,<addr-line>New York, NY</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name>
<affiliation><nlm:aff id="af78"><addr-line>Clinical Genetics Service, Department of Medicine</addr-line>
,<institution>Memorial Sloan-Kettering Cancer Center</institution>
,<addr-line>New York, NY</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name>
<affiliation><nlm:aff id="af79"><addr-line>GOG Statistical and Data Center</addr-line>
,<institution>Roswell Park Cancer Institute</institution>
,<addr-line>Buffalo, NY 14263</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Gustavo C" sort="Rodriguez, Gustavo C" uniqKey="Rodriguez G" first="Gustavo C." last="Rodriguez">Gustavo C. Rodriguez</name>
<affiliation><nlm:aff id="af80"><institution>NorthShore University Health System, Evanston Northwestern Healthcare</institution>
,<addr-line>Evanston IL 60201</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wakeley, Katie" sort="Wakeley, Katie" uniqKey="Wakeley K" first="Katie" last="Wakeley">Katie Wakeley</name>
<affiliation><nlm:aff id="af81"><institution>New England Medical Center, Tufts University</institution>
,<addr-line>Boston, MA 02111</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Boggess, John F" sort="Boggess, John F" uniqKey="Boggess J" first="John F." last="Boggess">John F. Boggess</name>
<affiliation><nlm:aff id="af82"><institution>University of North Carolina</institution>
,<addr-line>Chapel Hill, NC 27599</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Basil, Jack" sort="Basil, Jack" uniqKey="Basil J" first="Jack" last="Basil">Jack Basil</name>
<affiliation><nlm:aff id="af83"><institution>St Elizabeth Medical Center</institution>
,<addr-line>Edgewood, KY 41017</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schwartz, Peter E" sort="Schwartz, Peter E" uniqKey="Schwartz P" first="Peter E." last="Schwartz">Peter E. Schwartz</name>
<affiliation><nlm:aff id="af84"><institution>Yale University School of Medicine</institution>
,<addr-line>New Haven, CT 06510</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Blank, Stephanie V" sort="Blank, Stephanie V" uniqKey="Blank S" first="Stephanie V." last="Blank">Stephanie V. Blank</name>
<affiliation><nlm:aff id="af85"><institution>New York University School of Medicine</institution>
,<addr-line>New York, NY 10016</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name>
<affiliation><nlm:aff wicri:cut=" and" id="af86"><addr-line>Department of Internal Medicine</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af87"><addr-line>Molecular Virology</addr-line>
,<institution>Immunology and Medical Genetics, Division of Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University</institution>
,<addr-line>Columbus, OH 43210</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name>
<affiliation><nlm:aff id="af88"><institution>Istituto Oncologico Veneto, IRCCS, Immunology and Molecular Oncology Unit</institution>
,<addr-line>Padua</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Casella, Cinzia" sort="Casella, Cinzia" uniqKey="Casella C" first="Cinzia" last="Casella">Cinzia Casella</name>
<affiliation><nlm:aff id="af88"><institution>Istituto Oncologico Veneto, IRCCS, Immunology and Molecular Oncology Unit</institution>
,<addr-line>Padua</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N." last="Imyanitov">Evgeny N. Imyanitov</name>
<affiliation><nlm:aff id="af89"><institution>N.N. Petrov Institute of Oncology</institution>
,<addr-line>St Petersburg</addr-line>
,<country>Russia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Allavena, Anna" sort="Allavena, Anna" uniqKey="Allavena A" first="Anna" last="Allavena">Anna Allavena</name>
<affiliation><nlm:aff id="af90"><addr-line>Department of Genetics, Biology and Biochemistry</addr-line>
,<institution>University of Turin</institution>
,<addr-line>Turin</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name>
<affiliation><nlm:aff id="af91"><addr-line>Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology</addr-line>
,<institution>University of Cologne</institution>
,<addr-line>Cologne</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Versmold, Beatrix" sort="Versmold, Beatrix" uniqKey="Versmold B" first="Beatrix" last="Versmold">Beatrix Versmold</name>
<affiliation><nlm:aff id="af91"><addr-line>Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology</addr-line>
,<institution>University of Cologne</institution>
,<addr-line>Cologne</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name>
<affiliation><nlm:aff id="af92"><institution>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig</institution>
,<addr-line>Leipzig</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation><nlm:aff id="af93"><addr-line>Department of Obstetrics and Gynaecology</addr-line>
,<institution>Technical University Munich</institution>
,<addr-line>Munich</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ditsch, Nina" sort="Ditsch, Nina" uniqKey="Ditsch N" first="Nina" last="Ditsch">Nina Ditsch</name>
<affiliation><nlm:aff id="af94"><addr-line>Department of Obstetrics and Gynecology</addr-line>
,<institution>Ludwig-Maximilian University Munich</institution>
,<addr-line>Munich</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name>
<affiliation><nlm:aff id="af96"><addr-line>Molecular Genetics Laboratory, Department of Obstetrics and Gynaecology</addr-line>
,<institution>University of Duesseldorf</institution>
,<addr-line>Duesseldorf</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name>
<affiliation><nlm:aff id="af96"><addr-line>Molecular Genetics Laboratory, Department of Obstetrics and Gynaecology</addr-line>
,<institution>University of Duesseldorf</institution>
,<addr-line>Duesseldorf</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dei Ler, Helmut" sort="Dei Ler, Helmut" uniqKey="Dei Ler H" first="Helmut" last="Dei Ler">Helmut Dei Ler</name>
<affiliation><nlm:aff id="af97"><addr-line>Department of Obstetrics and Gynaecology</addr-line>
,<institution>University of Ulm</institution>
,<addr-line>Ulm</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fiebig, Britta" sort="Fiebig, Britta" uniqKey="Fiebig B" first="Britta" last="Fiebig">Britta Fiebig</name>
<affiliation><nlm:aff id="af98"><institution>Institute of Human Genetics, University of Regensburg</institution>
,<addr-line>Regensburg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Suttner, Christian" sort="Suttner, Christian" uniqKey="Suttner C" first="Christian" last="Suttner">Christian Suttner</name>
<affiliation><nlm:aff id="af99"><institution>Institute of Human Genetics, University of Heidelberg</institution>
,<addr-line>Heidelberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schonbuchner, Ines" sort="Schonbuchner, Ines" uniqKey="Schonbuchner I" first="Ines" last="Schönbuchner">Ines Schönbuchner</name>
<affiliation><nlm:aff id="af100"><institution>Institute of Human Genetics, University of Würzburg, Würzburg</institution>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gadzicki, Dorothea" sort="Gadzicki, Dorothea" uniqKey="Gadzicki D" first="Dorothea" last="Gadzicki">Dorothea Gadzicki</name>
<affiliation><nlm:aff wicri:cut=" and" id="af101"><institution>Institute of Cellular and Molecular Pathology, Medical University</institution>
,<addr-line>Hannover</addr-line>
,<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name>
<affiliation><nlm:aff id="af102"><institution>Hospital Clinico San Carlos</institution>
<addr-line>28040, Madrid</addr-line>
,<country>Spain</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name>
<affiliation><nlm:aff id="af102"><institution>Hospital Clinico San Carlos</institution>
<addr-line>28040, Madrid</addr-line>
,<country>Spain</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation><nlm:aff id="af3"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane, QLD 4029</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Human Molecular Genetics</title>
<idno type="ISSN">0964-6906</idno>
<idno type="eISSN">1460-2083</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Genome-wide association studies of breast cancer have identified multiple single nucleotide polymorphisms (SNPs) that are associated with increased breast cancer risks in the general population. In a previous study, we demonstrated that the minor alleles at three of these SNPs, in <italic>FGFR2, TNRC9</italic>
and <italic>MAP3K1</italic>
, also confer increased risks of breast cancer for <italic>BRCA1</italic>
or <italic>BRCA2</italic>
mutation carriers. Three additional SNPs rs3817198 at <italic>LSP1</italic>
, rs13387042 at 2q35 and rs13281615 at 8q24 have since been reported to be associated with breast cancer in the general population, and in this study we evaluated their association with breast cancer risk in 9442 <italic>BRCA1</italic>
and 5665 <italic>BRCA2</italic>
mutation carriers from 33 study centres. The minor allele of rs3817198 was associated with increased breast cancer risk only for <italic>BRCA2</italic>
mutation carriers [hazard ratio (HR) = 1.16, 95% CI: 1.07–1.25, <italic>P</italic>
-trend = 2.8 × 10<sup>−4</sup>
]. The best fit for the association of SNP rs13387042 at 2q35 with breast cancer risk was a dominant model for both <italic>BRCA1</italic>
and <italic>BRCA2</italic>
mutation carriers (<italic>BRCA1</italic>
: HR = 1.14, 95% CI: 1.04–1.25, <italic>P</italic>
= 0.0047; <italic>BRCA2</italic>
: HR = 1.18 95% CI: 1.04–1.33, <italic>P</italic>
= 0.0079). SNP rs13281615 at 8q24 was not associated with breast cancer for either <italic>BRCA1</italic>
or <italic>BRCA2</italic>
mutation carriers, but the estimated association for <italic>BRCA2</italic>
mutation carriers (per-allele HR = 1.06, 95% CI: 0.98–1.14) was consistent with odds ratio estimates derived from population-based case–control studies. The <italic>LSP1</italic>
and 2q35 SNPs appear to interact multiplicatively on breast cancer risk for <italic>BRCA2</italic>
mutation carriers. There was no evidence that the associations vary by mutation type depending on whether the mutated protein is predicted to be stable or not.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Mol Genet</journal-id>
<journal-id journal-id-type="publisher-id">hmg</journal-id>
<journal-id journal-id-type="hwp">hmg</journal-id>
<journal-title-group><journal-title>Human Molecular Genetics</journal-title>
</journal-title-group>
<issn pub-type="ppub">0964-6906</issn>
<issn pub-type="epub">1460-2083</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19656774</article-id>
<article-id pub-id-type="pmc">2782243</article-id>
<article-id pub-id-type="doi">10.1093/hmg/ddp372</article-id>
<article-id pub-id-type="publisher-id">ddp372</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Association Studies Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>Common variants in <italic>LSP1</italic>
, 2q35 and 8q24 and breast cancer risk for <italic>BRCA1</italic>
and <italic>BRCA2</italic>
mutation carriers</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Antoniou</surname>
<given-names>Antonis C.</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sinilnikova</surname>
<given-names>Olga M.</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McGuffog</surname>
<given-names>Lesley</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Healey</surname>
<given-names>Sue</given-names>
</name>
<xref ref-type="aff" rid="af3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nevanlinna</surname>
<given-names>Heli</given-names>
</name>
<xref ref-type="aff" rid="af4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Heikkinen</surname>
<given-names>Tuomas</given-names>
</name>
<xref ref-type="aff" rid="af4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Simard</surname>
<given-names>Jacques</given-names>
</name>
<xref ref-type="aff" rid="af5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Spurdle</surname>
<given-names>Amanda B.</given-names>
</name>
<xref ref-type="aff" rid="af3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Beesley</surname>
<given-names>Jonathan</given-names>
</name>
<xref ref-type="aff" rid="af3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Xiaoqing</given-names>
</name>
<xref ref-type="aff" rid="af3">3</xref>
</contrib>
<contrib contrib-type="author"><collab>The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer</collab>
<xref ref-type="aff" rid="af6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Neuhausen</surname>
<given-names>Susan L.</given-names>
</name>
<xref ref-type="aff" rid="af7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ding</surname>
<given-names>Yuan C.</given-names>
</name>
<xref ref-type="aff" rid="af7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Couch</surname>
<given-names>Fergus J.</given-names>
</name>
<xref ref-type="aff" rid="af8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Xianshu</given-names>
</name>
<xref ref-type="aff" rid="af8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fredericksen</surname>
<given-names>Zachary</given-names>
</name>
<xref ref-type="aff" rid="af8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peterlongo</surname>
<given-names>Paolo</given-names>
</name>
<xref ref-type="aff" rid="af9">9</xref>
<xref ref-type="aff" rid="af10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peissel</surname>
<given-names>Bernard</given-names>
</name>
<xref ref-type="aff" rid="af9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bonanni</surname>
<given-names>Bernardo</given-names>
</name>
<xref ref-type="aff" rid="af11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Viel</surname>
<given-names>Alessandra</given-names>
</name>
<xref ref-type="aff" rid="af12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bernard</surname>
<given-names>Loris</given-names>
</name>
<xref ref-type="aff" rid="af11">11</xref>
<xref ref-type="aff" rid="af13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Radice</surname>
<given-names>Paolo</given-names>
</name>
<xref ref-type="aff" rid="af9">9</xref>
<xref ref-type="aff" rid="af10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Szabo</surname>
<given-names>Csilla I.</given-names>
</name>
<xref ref-type="aff" rid="af14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Foretova</surname>
<given-names>Lenka</given-names>
</name>
<xref ref-type="aff" rid="af15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zikan</surname>
<given-names>Michal</given-names>
</name>
<xref ref-type="aff" rid="af16">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Claes</surname>
<given-names>Kathleen</given-names>
</name>
<xref ref-type="aff" rid="af17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Greene</surname>
<given-names>Mark H.</given-names>
</name>
<xref ref-type="aff" rid="af18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mai</surname>
<given-names>Phuong L.</given-names>
</name>
<xref ref-type="aff" rid="af18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rennert</surname>
<given-names>Gad</given-names>
</name>
<xref ref-type="aff" rid="af19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lejbkowicz</surname>
<given-names>Flavio</given-names>
</name>
<xref ref-type="aff" rid="af19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Andrulis</surname>
<given-names>Irene L.</given-names>
</name>
<xref ref-type="aff" rid="af20">20</xref>
<xref ref-type="aff" rid="af21">21</xref>
<xref ref-type="aff" rid="af22">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ozcelik</surname>
<given-names>Hilmi</given-names>
</name>
<xref ref-type="aff" rid="af21">21</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Glendon</surname>
<given-names>Gord</given-names>
</name>
<xref ref-type="aff" rid="af20">20</xref>
</contrib>
<contrib contrib-type="author"><collab>OCGN</collab>
<xref ref-type="aff" rid="af20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gerdes</surname>
<given-names>Anne-Marie</given-names>
</name>
<xref ref-type="aff" rid="af23">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thomassen</surname>
<given-names>Mads</given-names>
</name>
<xref ref-type="aff" rid="af23">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sunde</surname>
<given-names>Lone</given-names>
</name>
<xref ref-type="aff" rid="af24">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Caligo</surname>
<given-names>Maria A.</given-names>
</name>
<xref ref-type="aff" rid="af25">25</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Laitman</surname>
<given-names>Yael</given-names>
</name>
<xref ref-type="aff" rid="af26">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kontorovich</surname>
<given-names>Tair</given-names>
</name>
<xref ref-type="aff" rid="af26">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cohen</surname>
<given-names>Shimrit</given-names>
</name>
<xref ref-type="aff" rid="af26">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kaufman</surname>
<given-names>Bella</given-names>
</name>
<xref ref-type="aff" rid="af27">27</xref>
<xref ref-type="aff" rid="af28">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dagan</surname>
<given-names>Efrat</given-names>
</name>
<xref ref-type="aff" rid="af29">29</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baruch</surname>
<given-names>Ruth Gershoni</given-names>
</name>
<xref ref-type="aff" rid="af29">29</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Friedman</surname>
<given-names>Eitan</given-names>
</name>
<xref ref-type="aff" rid="af26">26</xref>
<xref ref-type="aff" rid="af28">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Harbst</surname>
<given-names>Katja</given-names>
</name>
<xref ref-type="aff" rid="af30">30</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Barbany-Bustinza</surname>
<given-names>Gisela</given-names>
</name>
<xref ref-type="aff" rid="af31">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rantala</surname>
<given-names>Johanna</given-names>
</name>
<xref ref-type="aff" rid="af31">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ehrencrona</surname>
<given-names>Hans</given-names>
</name>
<xref ref-type="aff" rid="af32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Karlsson</surname>
<given-names>Per</given-names>
</name>
<xref ref-type="aff" rid="af33">33</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Domchek</surname>
<given-names>Susan M.</given-names>
</name>
<xref ref-type="aff" rid="af34">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nathanson</surname>
<given-names>Katherine L.</given-names>
</name>
<xref ref-type="aff" rid="af34">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Osorio</surname>
<given-names>Ana</given-names>
</name>
<xref ref-type="aff" rid="af35">35</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blanco</surname>
<given-names>Ignacio</given-names>
</name>
<xref ref-type="aff" rid="af36">36</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lasa</surname>
<given-names>Adriana</given-names>
</name>
<xref ref-type="aff" rid="af37">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Benítez</surname>
<given-names>Javier</given-names>
</name>
<xref ref-type="aff" rid="af35">35</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hamann</surname>
<given-names>Ute</given-names>
</name>
<xref ref-type="aff" rid="af38">38</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hogervorst</surname>
<given-names>Frans B.L.</given-names>
</name>
<xref ref-type="aff" rid="af39">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rookus</surname>
<given-names>Matti A.</given-names>
</name>
<xref ref-type="aff" rid="af40">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Collee</surname>
<given-names>J. Margriet</given-names>
</name>
<xref ref-type="aff" rid="af41">41</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Devilee</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="af42">42</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ligtenberg</surname>
<given-names>Marjolijn J.</given-names>
</name>
<xref ref-type="aff" rid="af44">44</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van der Luijt</surname>
<given-names>Rob B.</given-names>
</name>
<xref ref-type="aff" rid="af45">45</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aalfs</surname>
<given-names>Cora M.</given-names>
</name>
<xref ref-type="aff" rid="af46">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Waisfisz</surname>
<given-names>Quinten</given-names>
</name>
<xref ref-type="aff" rid="af47">47</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wijnen</surname>
<given-names>Juul</given-names>
</name>
<xref ref-type="aff" rid="af43">43</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van Roozendaal</surname>
<given-names>Cornelis E.P.</given-names>
</name>
<xref ref-type="aff" rid="af48">48</xref>
</contrib>
<contrib contrib-type="author"><collab>HEBON</collab>
<xref ref-type="aff" rid="af49">49</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peock</surname>
<given-names>Susan</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cook</surname>
<given-names>Margaret</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Frost</surname>
<given-names>Debra</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Oliver</surname>
<given-names>Clare</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Platte</surname>
<given-names>Radka</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Evans</surname>
<given-names>D. Gareth</given-names>
</name>
<xref ref-type="aff" rid="af50">50</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lalloo</surname>
<given-names>Fiona</given-names>
</name>
<xref ref-type="aff" rid="af50">50</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eeles</surname>
<given-names>Rosalind</given-names>
</name>
<xref ref-type="aff" rid="af51">51</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Izatt</surname>
<given-names>Louise</given-names>
</name>
<xref ref-type="aff" rid="af52">52</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Davidson</surname>
<given-names>Rosemarie</given-names>
</name>
<xref ref-type="aff" rid="af53">53</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chu</surname>
<given-names>Carol</given-names>
</name>
<xref ref-type="aff" rid="af54">54</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eccles</surname>
<given-names>Diana</given-names>
</name>
<xref ref-type="aff" rid="af55">55</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cole</surname>
<given-names>Trevor</given-names>
</name>
<xref ref-type="aff" rid="af56">56</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hodgson</surname>
<given-names>Shirley</given-names>
</name>
<xref ref-type="aff" rid="af57">57</xref>
</contrib>
<contrib contrib-type="author"><collab>EMBRACE</collab>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Godwin</surname>
<given-names>Andrew K.</given-names>
</name>
<xref ref-type="aff" rid="af58">58</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stoppa-Lyonnet</surname>
<given-names>Dominique</given-names>
</name>
<xref ref-type="aff" rid="af59">59</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Buecher</surname>
<given-names>Bruno</given-names>
</name>
<xref ref-type="aff" rid="af60">60</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Léoné</surname>
<given-names>Mélanie</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bressac-de Paillerets</surname>
<given-names>Brigitte</given-names>
</name>
<xref ref-type="aff" rid="af61">61</xref>
<xref ref-type="aff" rid="af62">62</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Remenieras</surname>
<given-names>Audrey</given-names>
</name>
<xref ref-type="aff" rid="af61">61</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Caron</surname>
<given-names>Olivier</given-names>
</name>
<xref ref-type="aff" rid="af63">63</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lenoir</surname>
<given-names>Gilbert M.</given-names>
</name>
<xref ref-type="aff" rid="af61">61</xref>
<xref ref-type="aff" rid="af64">64</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sevenet</surname>
<given-names>Nicolas</given-names>
</name>
<xref ref-type="aff" rid="af65">65</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Longy</surname>
<given-names>Michel</given-names>
</name>
<xref ref-type="aff" rid="af65">65</xref>
<xref ref-type="aff" rid="af66">66</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ferrer</surname>
<given-names>Sandra Fert</given-names>
</name>
<xref ref-type="aff" rid="af67">67</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Prieur</surname>
<given-names>Fabienne</given-names>
</name>
<xref ref-type="aff" rid="af68">68</xref>
</contrib>
<contrib contrib-type="author"><collab>GEMO</collab>
<xref ref-type="aff" rid="af2">2</xref>
<xref ref-type="aff" rid="af59">59</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Goldgar</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="af69">69</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Miron</surname>
<given-names>Alexander</given-names>
</name>
<xref ref-type="aff" rid="af70">70</xref>
</contrib>
<contrib contrib-type="author"><name><surname>John</surname>
<given-names>Esther M.</given-names>
</name>
<xref ref-type="aff" rid="af71">71</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Buys</surname>
<given-names>Saundra S.</given-names>
</name>
<xref ref-type="aff" rid="af72">72</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Daly</surname>
<given-names>Mary B.</given-names>
</name>
<xref ref-type="aff" rid="af58">58</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hopper</surname>
<given-names>John L.</given-names>
</name>
<xref ref-type="aff" rid="af73">73</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Terry</surname>
<given-names>Mary Beth</given-names>
</name>
<xref ref-type="aff" rid="af74">74</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yassin</surname>
<given-names>Yosuf</given-names>
</name>
<xref ref-type="aff" rid="af70">70</xref>
</contrib>
<contrib contrib-type="author"><collab>Breast Cancer Family Registry, Christian Singer</collab>
<xref ref-type="aff" rid="af75">75</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gschwantler-Kaulich</surname>
<given-names>Daphne</given-names>
</name>
<xref ref-type="aff" rid="af75">75</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Staudigl</surname>
<given-names>Christine</given-names>
</name>
<xref ref-type="aff" rid="af75">75</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hansen</surname>
<given-names>Thomas v. O.</given-names>
</name>
<xref ref-type="aff" rid="af76">76</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Barkardottir</surname>
<given-names>Rosa Bjork</given-names>
</name>
<xref ref-type="aff" rid="af77">77</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kirchhoff</surname>
<given-names>Tomas</given-names>
</name>
<xref ref-type="aff" rid="af78">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pal</surname>
<given-names>Prodipto</given-names>
</name>
<xref ref-type="aff" rid="af78">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kosarin</surname>
<given-names>Kristi</given-names>
</name>
<xref ref-type="aff" rid="af78">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Offit</surname>
<given-names>Kenneth</given-names>
</name>
<xref ref-type="aff" rid="af78">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Piedmonte</surname>
<given-names>Marion</given-names>
</name>
<xref ref-type="aff" rid="af79">79</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rodriguez</surname>
<given-names>Gustavo C.</given-names>
</name>
<xref ref-type="aff" rid="af80">80</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wakeley</surname>
<given-names>Katie</given-names>
</name>
<xref ref-type="aff" rid="af81">81</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Boggess</surname>
<given-names>John F.</given-names>
</name>
<xref ref-type="aff" rid="af82">82</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Basil</surname>
<given-names>Jack</given-names>
</name>
<xref ref-type="aff" rid="af83">83</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schwartz</surname>
<given-names>Peter E.</given-names>
</name>
<xref ref-type="aff" rid="af84">84</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blank</surname>
<given-names>Stephanie V.</given-names>
</name>
<xref ref-type="aff" rid="af85">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Toland</surname>
<given-names>Amanda E.</given-names>
</name>
<xref ref-type="aff" rid="af86">86</xref>
<xref ref-type="aff" rid="af87">87</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Montagna</surname>
<given-names>Marco</given-names>
</name>
<xref ref-type="aff" rid="af88">88</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Casella</surname>
<given-names>Cinzia</given-names>
</name>
<xref ref-type="aff" rid="af88">88</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Imyanitov</surname>
<given-names>Evgeny N.</given-names>
</name>
<xref ref-type="aff" rid="af89">89</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Allavena</surname>
<given-names>Anna</given-names>
</name>
<xref ref-type="aff" rid="af90">90</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schmutzler</surname>
<given-names>Rita K.</given-names>
</name>
<xref ref-type="aff" rid="af91">91</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Versmold</surname>
<given-names>Beatrix</given-names>
</name>
<xref ref-type="aff" rid="af91">91</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Engel</surname>
<given-names>Christoph</given-names>
</name>
<xref ref-type="aff" rid="af92">92</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meindl</surname>
<given-names>Alfons</given-names>
</name>
<xref ref-type="aff" rid="af93">93</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ditsch</surname>
<given-names>Nina</given-names>
</name>
<xref ref-type="aff" rid="af94">94</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Arnold</surname>
<given-names>Norbert</given-names>
</name>
<xref ref-type="aff" rid="af96">96</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Niederacher</surname>
<given-names>Dieter</given-names>
</name>
<xref ref-type="aff" rid="af96">96</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Deißler</surname>
<given-names>Helmut</given-names>
</name>
<xref ref-type="aff" rid="af97">97</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fiebig</surname>
<given-names>Britta</given-names>
</name>
<xref ref-type="aff" rid="af98">98</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Suttner</surname>
<given-names>Christian</given-names>
</name>
<xref ref-type="aff" rid="af99">99</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schönbuchner</surname>
<given-names>Ines</given-names>
</name>
<xref ref-type="aff" rid="af100">100</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gadzicki</surname>
<given-names>Dorothea</given-names>
</name>
<xref ref-type="aff" rid="af101">101</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Caldes</surname>
<given-names>Trinidad</given-names>
</name>
<xref ref-type="aff" rid="af102">102</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de la Hoya</surname>
<given-names>Miguel</given-names>
</name>
<xref ref-type="aff" rid="af102">102</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pooley</surname>
<given-names>Karen A.</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Easton</surname>
<given-names>Douglas F.</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chenevix-Trench</surname>
<given-names>Georgia</given-names>
</name>
<xref ref-type="aff" rid="af3">3</xref>
<on-behalf-of>on behalf of CIMBA.</on-behalf-of>
</contrib>
</contrib-group>
<aff id="af1"><label>1</label>
<addr-line>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</aff>
<aff id="af2"><label>2</label>
<addr-line>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents</addr-line>
,<institution>Hospices Civils de Lyon/Centre Léon Bérard, UMR5201 CNRS, Université de Lyon</institution>
,<addr-line>Lyon</addr-line>
,<country>France</country>
,</aff>
<aff id="af3"><label>3</label>
<institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane, QLD 4029</addr-line>
,<country>Australia</country>
,</aff>
<aff id="af4"><label>4</label>
<addr-line>Department of Obstetrics and Gynecology</addr-line>
,<institution>Helsinki University Central Hospital</institution>
,<addr-line>Helsinki</addr-line>
,<country>Finland</country>
,</aff>
<aff id="af5"><label>5</label>
<addr-line>Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory</addr-line>
,<institution>Centre Hospitalier Universitaire de Québec and Laval University</institution>
,<addr-line>Quebec</addr-line>
,<country>Canada</country>
,</aff>
<aff id="af6"><label>6</label>
<institution>Peter MacCallum Cancer Institute</institution>
,<addr-line>Melbourne VIC 3002</addr-line>
,<country>Australia</country>
,</aff>
<aff id="af7"><label>7</label>
<addr-line>Department of Epidemiology</addr-line>
,<institution>University of California Irvine</institution>
,<addr-line>Irvine, CA</addr-line>
,<country>USA</country>
,</aff>
<aff id="af8"><label>8</label>
<addr-line>Mayo Clinic, Rochester, MN</addr-line>
,<country>USA</country>
,</aff>
<aff id="af9"><label>9</label>
<institution>Fondazione IRCCS Istituto Nazionale Tumori</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</aff>
<aff id="af10"><label>10</label>
<institution>Fondazione Istituto FIRC di Oncologia Molecolare</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</aff>
<aff id="af11"><label>11</label>
<institution>Istituto Europeo di Oncologia</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</aff>
<aff id="af12"><label>12</label>
<addr-line>Centro di Riferimento Oncologico</addr-line>
,<institution>IRCCS</institution>
,<addr-line>Aviano, PN</addr-line>
,<country>Italy</country>
,</aff>
<aff id="af13"><label>13</label>
<addr-line>Cogentech</addr-line>
,<institution>Consortium for Genomic Technologies</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</aff>
<aff id="af14"><label>14</label>
<addr-line>Department of Laboratory Medicine and Pathology</addr-line>
,<institution>Mayo Clinic College of Medicine</institution>
,<addr-line>Rochester, MN</addr-line>
,<country>USA</country>
,</aff>
<aff id="af15"><label>15</label>
<addr-line>Department of Cancer Epidemiology and Genetics</addr-line>
,<institution>Masaryk Memorial Cancer Institute</institution>
,<addr-line>Brno</addr-line>
,<country>Czech Republic</country>
,</aff>
<aff id="af16"><label>16</label>
<addr-line>Department of Biochemistry and Experimental Oncology, First Faculty of Medicine</addr-line>
,<institution>Charles University</institution>
,<addr-line>Prague</addr-line>
,<country>Czech Republic</country>
,</aff>
<aff id="af17"><label>17</label>
<addr-line>Center for Medical Genetics</addr-line>
,<institution>Ghent University Hospital</institution>
,<addr-line>Ghent</addr-line>
,<country>Belgium</country>
,</aff>
<aff id="af18"><label>18</label>
<addr-line>Clinical Genetics Branch</addr-line>
,<institution>US National Cancer Institute</institution>
,<addr-line>Rockville, MD</addr-line>
,<country>USA</country>
,</aff>
<aff id="af19"><label>19</label>
<addr-line>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology</addr-line>
,<institution>Carmel Medical Center and B. Rappaport Faculty of Medicine</institution>
,<addr-line>Technion, Haifa</addr-line>
,<country>Israel</country>
,</aff>
<aff id="af20"><label>20</label>
<institution>Ontario Cancer Genetics Network, Cancer Care Ontario</institution>
,<addr-line>Ontario</addr-line>
,<country>Canada</country>
,</aff>
<aff id="af21"><label>21</label>
<addr-line>Fred A. Litwin Center for Cancer Genetics</addr-line>
,<institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
,<addr-line>Ontario</addr-line>
,<country>Canada</country>
,</aff>
<aff id="af22"><label>22</label>
<addr-line>Department of Molecular Genetics</addr-line>
,<institution>University of Toronto</institution>
,<addr-line>Toronto, Ontario</addr-line>
,<country>Canada</country>
,</aff>
<aff id="af23"><label>23</label>
<addr-line>Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense</addr-line>
,<country>Denmark</country>
,</aff>
<aff id="af24"><label>24</label>
<addr-line>Department of Clinical Genetics</addr-line>
,<institution>Aarhus University Hospital</institution>
,<addr-line>Aarhus</addr-line>
,<country>Denmark</country>
,</aff>
<aff id="af25"><label>25</label>
<addr-line>Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology</addr-line>
,<institution>University of Pisa and Pisa University Hospital</institution>
,<addr-line>Pisa</addr-line>
,<country>Italy</country>
,</aff>
<aff id="af26"><label>26</label>
<addr-line>The Susanne Levy Gertner Oncogenetics Unit</addr-line>
,<institution>Chaim Sheba Medical Center</institution>
,<addr-line>Tel Hashomer</addr-line>
,<country>Israel</country>
,</aff>
<aff id="af27"><label>27</label>
<institution>The Oncology Institute Chaim Sheba Medical Center</institution>
,<addr-line>Tel Hashomer</addr-line>
,<country>Israel</country>
,</aff>
<aff id="af28"><label>28</label>
<addr-line>The Sackler School of Medicine</addr-line>
,<institution>Tel-Aviv University</institution>
,<addr-line>Tel-Aviv</addr-line>
,<country>Israel</country>
,</aff>
<aff id="af29"><label>29</label>
<institution>Genetics Institute Rambam Medical Center</institution>
,<addr-line>Haifa</addr-line>
,<country>Israel</country>
,</aff>
<aff id="af30"><label>30</label>
<addr-line>Department Oncology</addr-line>
,<institution>Lund University</institution>
,<country>Sweden</country>
,</aff>
<aff id="af31"><label>31</label>
<addr-line>Department of Clinical Genetics</addr-line>
,<institution>Karolinska University Hospital</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</aff>
<aff id="af32"><label>32</label>
<addr-line>Department of Genetics and Pathology</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>Uppsala</addr-line>
,<country>Sweden</country>
,</aff>
<aff id="af33"><label>33</label>
<addr-line>Department of Oncology</addr-line>
,<institution>Sahlgrenska University</institution>
,<addr-line>Gothenburg</addr-line>
,<country>Sweden</country>
,</aff>
<aff id="af34"><label>34</label>
<institution>University of Pennsylvania</institution>
,<addr-line>Philadelphia, PA</addr-line>
,<country>USA</country>
,</aff>
<aff id="af35"><label>35</label>
<addr-line>Group of Human Genetics, Human Cancer Genetics Programme</addr-line>
,<institution>Spanish National Cancer Centre (CNIO) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERERER), Instituto de Salud Carlos III</institution>
,<addr-line>Madrid</addr-line>
,<country>Spain</country>
,</aff>
<aff id="af36"><label>36</label>
<addr-line>Cancer Genetics Counseling Program</addr-line>
,<institution>Catalan Institute of Oncology (ICO)</institution>
,<addr-line>Barcelona</addr-line>
,<country>Spain</country>
,</aff>
<aff id="af37"><label>37</label>
<addr-line>Genetics Service</addr-line>
,<institution>Hospital de la Santa Creu i Sant Pau</institution>
,<addr-line>Barcelona</addr-line>
,<country>Spain</country>
,</aff>
<aff id="af38"><label>38</label>
<addr-line>Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580 69120, Heidelberg</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af39"><label>39</label>
<addr-line>Family Cancer Clinic, Department of Pathology</addr-line>
,<institution>The Netherlands Cancer Institute</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af40"><label>40</label>
<addr-line>Department of Epidemiology</addr-line>
,<institution>The Netherlands Cancer Institute</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af41"><label>41</label>
<addr-line>Department of Clinical Genetics, Rotterdam Family Cancer Clinic</addr-line>
,<institution>Erasmus University Medical Center</institution>
,<addr-line>Rotterdam</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af42"><label>42</label>
<addr-line>Department of Genetic Epidemiology</addr-line>
and</aff>
<aff id="af43"><label>43</label>
<addr-line>Center for Human and Clinical Genetics</addr-line>
,<institution>Leiden University Medical Center</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af44"><label>44</label>
<addr-line>Department of Human Genetics</addr-line>
,<institution>Radboud University Medical Center</institution>
,<addr-line>Nijmegen</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af45"><label>45</label>
<addr-line>Department of Clinical Molecular Genetics</addr-line>
,<institution>Utrecht University Medical Center</institution>
,<country>The Netherlands</country>
,</aff>
<aff id="af46"><label>46</label>
<addr-line>Department of Clinical Genetics</addr-line>
,<institution>Academic Medical Center</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af47"><label>47</label>
<addr-line>Department of Clinical Genetics</addr-line>
,<institution>VU University Medical Center</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af48"><label>48</label>
<addr-line>Department of Clinical Genetics</addr-line>
,<institution>University Medical Center</institution>
,<addr-line>Maastricht</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af49"><label>49</label>
<institution>HEereditary Breast and Ovarian cancer group Netherlands (HEBON)</institution>
,</aff>
<aff id="af50"><label>50</label>
<addr-line>Genetic Medicine, Manchester Academic Health Sciences Centre</addr-line>
,<institution>Central Manchester University Hospitals NHS Foundation Trust</institution>
,<addr-line>Manchester</addr-line>
,<country>UK</country>
,</aff>
<aff id="af51"><label>51</label>
<addr-line>Translational Cancer Genetics Team</addr-line>
,<institution>The Institute of Cancer Research and Royal Marsden NHS Foundation Trust</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
,</aff>
<aff id="af52"><label>52</label>
<institution>Clinical Genetics, Guy's Hospital</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
,</aff>
<aff id="af53"><label>53</label>
<institution>Ferguson-Smith Centre for Clinical Genetics</institution>
,<addr-line>Glasgow</addr-line>
,<country>UK</country>
,</aff>
<aff id="af54"><label>54</label>
<institution>Yorkshire Regional Genetics Service</institution>
,<addr-line>Leeds</addr-line>
,<country>UK</country>
,</aff>
<aff id="af55"><label>55</label>
<addr-line>Wessex Clinical Genetics Service</addr-line>
,<institution>Princess Anne Hospital</institution>
,<addr-line>Southampton</addr-line>
,<country>UK</country>
,</aff>
<aff id="af56"><label>56</label>
<addr-line>West Midlands Regional Genetics Service</addr-line>
,<institution>Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston</institution>
,<addr-line>Birmingham</addr-line>
,<country>UK</country>
,</aff>
<aff id="af57"><label>57</label>
<addr-line>Department of Cancer Genetics</addr-line>
,<institution>St Georges Hospital, University of London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
,</aff>
<aff id="af58"><label>58</label>
<institution>Fox Chase Cancer Center</institution>
,<addr-line>Philadelphia, PA</addr-line>
,<country>USA</country>
,</aff>
<aff id="af59"><label>59</label>
<addr-line>INSERM U509, Service de Génétique Oncologique</addr-line>
,<institution>Institut Curie, and Université Paris-Descartes</institution>
,<addr-line>Paris</addr-line>
,<country>France</country>
,</aff>
<aff id="af60"><label>60</label>
<addr-line>Département de Génétique</addr-line>
,<institution>Institut Curie</institution>
,<addr-line>Paris</addr-line>
,<country>France</country>
,</aff>
<aff id="af61"><label>61</label>
<addr-line>Genetics Department</addr-line>
,<institution>Institut de Cancérologie Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</aff>
<aff id="af62"><label>62</label>
<addr-line>INSERM U946</addr-line>
,<institution>Institut de Cancérologie Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</aff>
<aff id="af63"><label>63</label>
<addr-line>Consultation de Génétique, Département de Médecine</addr-line>
,<institution>Institut de Cancérologie Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</aff>
<aff id="af64"><label>64</label>
<addr-line>CNRS FRE2939</addr-line>
,<institution>Institut de Cancérologie Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</aff>
<aff id="af65"><label>65</label>
<addr-line>Laboratoire de Génétique Constitutionnelle</addr-line>
,<institution>Institut Bergonié</institution>
,<addr-line>Bordeaux</addr-line>
,<country>France</country>
,</aff>
<aff id="af66"><label>66</label>
<addr-line>INSERM U916</addr-line>
,<institution>Institut Bergonié</institution>
,<addr-line>Bordeaux</addr-line>
,<country>France</country>
,</aff>
<aff id="af67"><label>67</label>
<addr-line>Laboratoire de Génétique Chromosomique</addr-line>
,<institution>Hôtel Dieu Centre Hospitalier</institution>
,<addr-line>Chambéry</addr-line>
,<country>France</country>
,</aff>
<aff id="af68"><label>68</label>
<addr-line>Service de Génétique Clinique Chromosomique et Moléculaire</addr-line>
,<institution>CHU de St Etienne</institution>
,<addr-line>St Etienne</addr-line>
,<country>France</country>
,</aff>
<aff id="af69"><label>69</label>
<addr-line>Department of Dermatology</addr-line>
,<institution>University of Utah</institution>
,<addr-line>Utah</addr-line>
,<country>USA</country>
,</aff>
<aff id="af70"><label>70</label>
<institution>Dana-Farber Cancer Institute</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</aff>
<aff id="af71"><label>71</label>
<addr-line>Northern California Cancer Center</addr-line>
,<institution>Fremont and Stanford University School of Medicine</institution>
,<addr-line>Stanford, CA</addr-line>
,<country>USA</country>
,</aff>
<aff id="af72"><label>72</label>
<institution>Huntsman Cancer Institute, University of Utah Health Sciences Centre</institution>
,<addr-line>Salt Lake City, UT</addr-line>
,<country>USA</country>
,</aff>
<aff id="af73"><label>73</label>
<institution>The University of Melbourne</institution>
,<addr-line>Melbourne</addr-line>
,<country>Australia</country>
,</aff>
<aff id="af74"><label>74</label>
<institution>Columbia University</institution>
,<addr-line>New York, NY</addr-line>
,<country>USA</country>
,</aff>
<aff id="af75"><label>75</label>
<addr-line>Division of Special Gynecology, Department of OB/GYN</addr-line>
,<institution>Medical University of Vienna</institution>
,<addr-line>Vienna</addr-line>
,<country>Austria</country>
,</aff>
<aff id="af76"><label>76</label>
<addr-line>Department of Clinical Biochemistry, Rigshospitalet</addr-line>
,<institution>University of Copenhagen</institution>
,<addr-line>Copenhagen</addr-line>
,<country>Denmark</country>
,</aff>
<aff id="af77"><label>77</label>
<addr-line>Department of Pathology</addr-line>
,<institution>Landspitali-University Hospital</institution>
,<addr-line>Reykjavik</addr-line>
,<country>Iceland</country>
,</aff>
<aff id="af78"><label>78</label>
<addr-line>Clinical Genetics Service, Department of Medicine</addr-line>
,<institution>Memorial Sloan-Kettering Cancer Center</institution>
,<addr-line>New York, NY</addr-line>
,<country>USA</country>
,</aff>
<aff id="af79"><label>79</label>
<addr-line>GOG Statistical and Data Center</addr-line>
,<institution>Roswell Park Cancer Institute</institution>
,<addr-line>Buffalo, NY 14263</addr-line>
,<country>USA</country>
,</aff>
<aff id="af80"><label>80</label>
<institution>NorthShore University Health System, Evanston Northwestern Healthcare</institution>
,<addr-line>Evanston IL 60201</addr-line>
,<country>USA</country>
,</aff>
<aff id="af81"><label>81</label>
<institution>New England Medical Center, Tufts University</institution>
,<addr-line>Boston, MA 02111</addr-line>
,<country>USA</country>
,</aff>
<aff id="af82"><label>82</label>
<institution>University of North Carolina</institution>
,<addr-line>Chapel Hill, NC 27599</addr-line>
,<country>USA</country>
,</aff>
<aff id="af83"><label>83</label>
<institution>St Elizabeth Medical Center</institution>
,<addr-line>Edgewood, KY 41017</addr-line>
,<country>USA</country>
,</aff>
<aff id="af84"><label>84</label>
<institution>Yale University School of Medicine</institution>
,<addr-line>New Haven, CT 06510</addr-line>
,<country>USA</country>
,</aff>
<aff id="af85"><label>85</label>
<institution>New York University School of Medicine</institution>
,<addr-line>New York, NY 10016</addr-line>
,<country>USA</country>
,</aff>
<aff id="af86"><label>86</label>
<addr-line>Department of Internal Medicine</addr-line>
and</aff>
<aff id="af87"><label>87</label>
<addr-line>Molecular Virology</addr-line>
,<institution>Immunology and Medical Genetics, Division of Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University</institution>
,<addr-line>Columbus, OH 43210</addr-line>
,<country>USA</country>
,</aff>
<aff id="af88"><label>88</label>
<institution>Istituto Oncologico Veneto, IRCCS, Immunology and Molecular Oncology Unit</institution>
,<addr-line>Padua</addr-line>
,<country>Italy</country>
,</aff>
<aff id="af89"><label>89</label>
<institution>N.N. Petrov Institute of Oncology</institution>
,<addr-line>St Petersburg</addr-line>
,<country>Russia</country>
,</aff>
<aff id="af90"><label>90</label>
<addr-line>Department of Genetics, Biology and Biochemistry</addr-line>
,<institution>University of Turin</institution>
,<addr-line>Turin</addr-line>
,<country>Italy</country>
,</aff>
<aff id="af91"><label>91</label>
<addr-line>Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology</addr-line>
,<institution>University of Cologne</institution>
,<addr-line>Cologne</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af92"><label>92</label>
<institution>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig</institution>
,<addr-line>Leipzig</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af93"><label>93</label>
<addr-line>Department of Obstetrics and Gynaecology</addr-line>
,<institution>Technical University Munich</institution>
,<addr-line>Munich</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af94"><label>94</label>
<addr-line>Department of Obstetrics and Gynecology</addr-line>
,<institution>Ludwig-Maximilian University Munich</institution>
,<addr-line>Munich</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af95"><label>95</label>
<addr-line>Department of Obstetrics and Gynaecology</addr-line>
,<institution>University of Schleswig-Holstein</institution>
,<addr-line>Campus Kiel</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af96"><label>96</label>
<addr-line>Molecular Genetics Laboratory, Department of Obstetrics and Gynaecology</addr-line>
,<institution>University of Duesseldorf</institution>
,<addr-line>Duesseldorf</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af97"><label>97</label>
<addr-line>Department of Obstetrics and Gynaecology</addr-line>
,<institution>University of Ulm</institution>
,<addr-line>Ulm</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af98"><label>98</label>
<institution>Institute of Human Genetics, University of Regensburg</institution>
,<addr-line>Regensburg</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af99"><label>99</label>
<institution>Institute of Human Genetics, University of Heidelberg</institution>
,<addr-line>Heidelberg</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af100"><label>100</label>
<institution>Institute of Human Genetics, University of Würzburg, Würzburg</institution>
,<country>Germany</country>
,</aff>
<aff id="af101"><label>101</label>
<institution>Institute of Cellular and Molecular Pathology, Medical University</institution>
,<addr-line>Hannover</addr-line>
,<country>Germany</country>
and</aff>
<aff id="af102"><label>102</label>
<institution>Hospital Clinico San Carlos</institution>
<addr-line>28040, Madrid</addr-line>
,<country>Spain</country>
</aff>
<author-notes><corresp id="cor1"><label>*</label>
To whom correspondence should be addressed at: <addr-line>CR-UK Genetic Epidemiology, Strangeways Research Laboratory</addr-line>
, <institution>Worts Causeway</institution>
, <addr-line>Cambridge CB1 8RN</addr-line>
, <country>UK</country>
. Tel: <phone>+44 1223740163</phone>
; fax: <fax>+44 122740159</fax>
; Email: <email>antonis@srl.cam.ac.uk</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>15</day>
<month>11</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="epub"><day>5</day>
<month>8</month>
<year>2009</year>
</pub-date>
<volume>18</volume>
<issue>22</issue>
<fpage>4442</fpage>
<lpage>4456</lpage>
<history><date date-type="received"><day>26</day>
<month>5</month>
<year>2009</year>
</date>
<date date-type="accepted"><day>3</day>
<month>8</month>
<year>2009</year>
</date>
</history>
<permissions><copyright-statement>© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org</copyright-statement>
</permissions>
<abstract><p>Genome-wide association studies of breast cancer have identified multiple single nucleotide polymorphisms (SNPs) that are associated with increased breast cancer risks in the general population. In a previous study, we demonstrated that the minor alleles at three of these SNPs, in <italic>FGFR2, TNRC9</italic>
and <italic>MAP3K1</italic>
, also confer increased risks of breast cancer for <italic>BRCA1</italic>
or <italic>BRCA2</italic>
mutation carriers. Three additional SNPs rs3817198 at <italic>LSP1</italic>
, rs13387042 at 2q35 and rs13281615 at 8q24 have since been reported to be associated with breast cancer in the general population, and in this study we evaluated their association with breast cancer risk in 9442 <italic>BRCA1</italic>
and 5665 <italic>BRCA2</italic>
mutation carriers from 33 study centres. The minor allele of rs3817198 was associated with increased breast cancer risk only for <italic>BRCA2</italic>
mutation carriers [hazard ratio (HR) = 1.16, 95% CI: 1.07–1.25, <italic>P</italic>
-trend = 2.8 × 10<sup>−4</sup>
]. The best fit for the association of SNP rs13387042 at 2q35 with breast cancer risk was a dominant model for both <italic>BRCA1</italic>
and <italic>BRCA2</italic>
mutation carriers (<italic>BRCA1</italic>
: HR = 1.14, 95% CI: 1.04–1.25, <italic>P</italic>
= 0.0047; <italic>BRCA2</italic>
: HR = 1.18 95% CI: 1.04–1.33, <italic>P</italic>
= 0.0079). SNP rs13281615 at 8q24 was not associated with breast cancer for either <italic>BRCA1</italic>
or <italic>BRCA2</italic>
mutation carriers, but the estimated association for <italic>BRCA2</italic>
mutation carriers (per-allele HR = 1.06, 95% CI: 0.98–1.14) was consistent with odds ratio estimates derived from population-based case–control studies. The <italic>LSP1</italic>
and 2q35 SNPs appear to interact multiplicatively on breast cancer risk for <italic>BRCA2</italic>
mutation carriers. There was no evidence that the associations vary by mutation type depending on whether the mutated protein is predicted to be stable or not.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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