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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade</title><author><name sortKey="Purrington, Kristen S" sort="Purrington, Kristen S" uniqKey="Purrington K" first="Kristen S." last="Purrington">Kristen S. Purrington</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Oncology</addr-line>,<institution>Wayne State University School of Medicine and Karmanos Cancer Institute</institution>,<addr-line>Detroit</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Slettedahl, Seth" sort="Slettedahl, Seth" uniqKey="Slettedahl S" first="Seth" last="Slettedahl">Seth Slettedahl</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="af9"><addr-line>Department of Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="af13"><addr-line>Copenhagen General Population Study</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af14"><addr-line>Department of Clinical Biochemistry</addr-line>,<institution>Herlev Hospital, Copenhagen University Hospital, University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="af15"><addr-line>Ontario Cancer Genetics Network</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af18"><addr-line>Department of Molecular Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="af21"><addr-line>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Carpenter, Jane" sort="Carpenter, Jane" uniqKey="Carpenter J" first="Jane" last="Carpenter">Jane Carpenter</name><affiliation><nlm:aff id="af23"><addr-line>Australian Breast Cancer Tissue Bank</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation><nlm:aff id="af25"><addr-line>Molecular Diagnostics Laboratory INRASTES</addr-line>,<institution>National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="af26"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="af27"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af30"><addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology</addr-line>,<institution>University of California at Los Angeles</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="af31"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af32"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="af34"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu</addr-line>,<institution>University of Oulu, Oulu University Hospital/NordLab Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="af35"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af40"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="af7"><addr-line>Department of Molecular Medicine and Surgery</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="af41"><addr-line>Department of Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="af43"><addr-line>Human Genetics Group, Human Cancer Genetics Program</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af44"><addr-line>Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="af45"><addr-line>Division of Genetics and Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af46"><addr-line>Division of Breast Cancer Research</addr-line>,<institution>Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="af47"><addr-line>Department of Genetics, Institute for Cancer Research</addr-line>,<institution>Oslo University Hospital, Radiumhospitalet</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af48"><addr-line>Faculty of Medicine (Faculty Division Ahus)</addr-line>,<institution>University of Oslo (UiO)</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country>,</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="af49"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018</addr-line>,<institution>Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af50"><institution>University Paris-Sud, UMRS 1018</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="af51"><addr-line>Division of Gynaecology and Obstetrics</addr-line>,<institution>Technische Universität München</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Fagerholm, Rainer" sort="Fagerholm, Rainer" uniqKey="Fagerholm R" first="Rainer" last="Fagerholm">Rainer Fagerholm</name><affiliation><nlm:aff id="af10"><addr-line>Department of Obstetrics and Gynecology, Oncology and Clinical Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="af11"><addr-line>Department of Clinical Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="af12"><addr-line>Department of Oncology</addr-line>,<institution>University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="af14"><addr-line>Department of Clinical Biochemistry</addr-line>,<institution>Herlev Hospital, Copenhagen University Hospital, University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="af13"><addr-line>Copenhagen General Population Study</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="af52"><addr-line>Department of Breast Surgery, Herlev Hospital</addr-line>,<institution>Copenhagen University Hospital</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="af2"><addr-line>Department of Laboratory Medicine and Pathology</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Olswold, Curtis" sort="Olswold, Curtis" uniqKey="Olswold C" first="Curtis" last="Olswold">Curtis Olswold</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="af19"><addr-line>Department of Laboratory Medicine and Pathobiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af53"><addr-line>Laboratory Medicine Program</addr-line>,<institution>University Health Network</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="af16"><addr-line>Prosserman Centre for Health Research</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af20"><addr-line>Division of Epidemiology, Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name><affiliation><nlm:aff id="af17"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="af21"><addr-line>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="af22"><addr-line>Academic Unit of Pathology, Department of Neuroscience</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="af54"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="af54"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Clarke, Christine" sort="Clarke, Christine" uniqKey="Clarke C" first="Christine" last="Clarke">Christine Clarke</name><affiliation><nlm:aff id="af24"><addr-line>Westmead Institute for Cancer Research, Sydney Medical School Westmead</addr-line>,<institution>University of Sydney at the Westmead Millennium Institute</institution>,<addr-line>Westmead</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Scott, Rodney" sort="Scott, Rodney" uniqKey="Scott R" first="Rodney" last="Scott">Rodney Scott</name><affiliation><nlm:aff id="af55"><addr-line>Division of Genetics</addr-line>,<institution>Hunter Area Pathology Service and University of Newcastle</institution>,<addr-line>Newcastle</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation><nlm:aff id="af25"><addr-line>Molecular Diagnostics Laboratory INRASTES</addr-line>,<institution>National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</nlm:aff></affiliation></author><author><name sortKey="Fountzilas, George" sort="Fountzilas, George" uniqKey="Fountzilas G" first="George" last="Fountzilas">George Fountzilas</name><affiliation><nlm:aff id="af56"><addr-line>Department of Medical Oncology, “Papageorgiou” Hospital</addr-line>,<institution>Aristotle University of Thessaloniki School of Medicine</institution>,<addr-line>Thessaloniki</addr-line>,<country>Greece</country>,</nlm:aff></affiliation></author><author><name sortKey="Konstantopoulou, Irene" sort="Konstantopoulou, Irene" uniqKey="Konstantopoulou I" first="Irene" last="Konstantopoulou">Irene Konstantopoulou</name><affiliation><nlm:aff id="af25"><addr-line>Molecular Diagnostics Laboratory INRASTES</addr-line>,<institution>National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="af26"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation><nlm:aff id="af26"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="af57"><addr-line>Epidemiology Program, Cancer Research Center</addr-line>,<institution>University of Hawaii</institution>,<addr-line>Honolulu</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="af28"><addr-line>Institute of Human Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Hartmann, Arndt" sort="Hartmann, Arndt" uniqKey="Hartmann A" first="Arndt" last="Hartmann">Arndt Hartmann</name><affiliation><nlm:aff id="af29"><addr-line>Institute of Pathology</addr-line>,<institution>University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="af27"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="af31"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af32"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="af31"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af32"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="af31"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af33"><addr-line>Cancer Center</addr-line>,<institution>Kuopio University Hospital</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="af58"><addr-line>Department of Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="af34"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu</addr-line>,<institution>University of Oulu, Oulu University Hospital/NordLab Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Kauppila, Saila" sort="Kauppila, Saila" uniqKey="Kauppila S" first="Saila" last="Kauppila">Saila Kauppila</name><affiliation><nlm:aff id="af59"><addr-line>Department of Pathology</addr-line>,<institution>Oulu University Hospital, University of Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation><nlm:aff id="af35"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af40"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="af60"><institution>Saarland Cancer Registry</institution>,<addr-line>Saarbrücken</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="af35"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="af8"><addr-line>Department of Oncology–Pathology</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Balleine, Rosemary" sort="Balleine, Rosemary" uniqKey="Balleine R" first="Rosemary" last="Balleine">Rosemary Balleine</name><affiliation><nlm:aff id="af62"><institution>Westmead Millenium Institute for Medical Research</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Perez">Jose Ignacio Arias Perez</name><affiliation><nlm:aff id="af63"><addr-line>Servicio de Cirugía General y Especialidades</addr-line>,<institution>Hospital Monte Naranco</institution>,<addr-line>Oviedo</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Pilar Zamora, M" sort="Pilar Zamora, M" uniqKey="Pilar Zamora M" first="M." last="Pilar Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="af65"><addr-line>Servicio de Oncología Médica</addr-line>,<institution>Hospital Universitario La Paz</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Menendez, Primitiva" sort="Menendez, Primitiva" uniqKey="Menendez P" first="Primitiva" last="Menéndez">Primitiva Menéndez</name><affiliation><nlm:aff id="af64"><addr-line>Servicio de Anatomía Patológica</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="af66"><addr-line>Breakthrough Breast Cancer Research Centre and Division of Breast Cancer Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation><nlm:aff id="af45"><addr-line>Division of Genetics and Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="af66"><addr-line>Breakthrough Breast Cancer Research Centre and Division of Breast Cancer Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Arveux, Patrick" sort="Arveux, Patrick" uniqKey="Arveux P" first="Patrick" last="Arveux">Patrick Arveux</name><affiliation><nlm:aff id="af68"><addr-line>Center Georges-Francois Leclerc</addr-line>,<institution>Registry of Gynecologic Tumors</institution>,<addr-line>Dijon</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Kerbrat, Pierre" sort="Kerbrat, Pierre" uniqKey="Kerbrat P" first="Pierre" last="Kerbrat">Pierre Kerbrat</name><affiliation><nlm:aff id="af69"><institution>Centre Eugène Marquis, Department of Medical Oncology</institution>,<addr-line>Rennes</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="af49"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018</addr-line>,<institution>Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af50"><institution>University Paris-Sud, UMRS 1018</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Bugert, Peter" sort="Bugert, Peter" uniqKey="Bugert P" first="Peter" last="Bugert">Peter Bugert</name><affiliation><nlm:aff id="af70"><institution>German Red Cross Blood Service of Baden-Württemberg-Hessen</institution>,<addr-line>Mannheim</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af71"><addr-line>Medical Faculty Mannheim, Institute of Transfusion Medicine and Immunology</addr-line>,<institution>Heidelberg University</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="af72"><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center</addr-line>,<institution>The Ohio State University</institution>,<addr-line>Columbus</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B." last="Ambrosone">Christine B. Ambrosone</name><affiliation><nlm:aff id="af73"><institution>Roswell Park Cancer Institute</institution>,<addr-line>Buffalo</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Labreche, France" sort="Labreche, France" uniqKey="Labreche F" first="France" last="Labrèche">France Labrèche</name><affiliation><nlm:aff id="af74"><addr-line>Department of Environmental & Occupational Health and of Social & Preventive Medicine</addr-line>,<institution>School of Public Health, Université de Montréal</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name><affiliation><nlm:aff id="af75"><addr-line>Department of Medicine</addr-line>,<institution>McGill University</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af76"><addr-line>Division of Clinical Epidemiology</addr-line>,<institution>McGill University Health Centre, Royal Victoria Hospital</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="af77"><addr-line>Cancer Genomics Laboratory</addr-line>,<institution>Centre Hospitalier Universitaire de Québec Research Center and Laval University</institution>,<addr-line>Quebec City</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation><nlm:aff id="af78"><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lee, Eunjung" sort="Lee, Eunjung" uniqKey="Lee E" first="Eunjung" last="Lee">Eunjung Lee</name><affiliation><nlm:aff id="af26"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Dite, Gillian S" sort="Dite, Gillian S" uniqKey="Dite G" first="Gillian S." last="Dite">Gillian S. Dite</name><affiliation><nlm:aff id="af79"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="af79"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="af80"><addr-line>Department of Pathology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="af82"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center</addr-line>,<institution>Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Martha" sort="Shrubsole, Martha" uniqKey="Shrubsole M" first="Martha" last="Shrubsole">Martha Shrubsole</name><affiliation><nlm:aff id="af72"><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center</addr-line>,<institution>The Ohio State University</institution>,<addr-line>Columbus</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Deming Halverson, Sandra" sort="Deming Halverson, Sandra" uniqKey="Deming Halverson S" first="Sandra" last="Deming-Halverson">Sandra Deming-Halverson</name><affiliation><nlm:aff id="af82"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center</addr-line>,<institution>Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ficarazzi, Filomena" sort="Ficarazzi, Filomena" uniqKey="Ficarazzi F" first="Filomena" last="Ficarazzi">Filomena Ficarazzi</name><affiliation><nlm:aff id="af83"><institution>Cogentech Cancer Genetic Test Laboratory</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af84"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><affiliation><nlm:aff id="af85"><addr-line>Division of Cancer Prevention and Genetics</addr-line>,<institution>Istituto Europeo di Oncologia (IEO)</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="af84"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="af86"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name><affiliation><nlm:aff id="af86"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="af87"><addr-line>Department of Surgical Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="af89"><addr-line>Family Cancer Clinic, Department of Medical Oncology</addr-line>,<institution>Erasmus MC-Daniel den Hoed Cancer Centrer</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="af90"><institution>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)</institution>,<addr-line>Bochum</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation><nlm:aff id="af91"><addr-line>Department of Internal Medicine</addr-line>,<institution>Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus</institution>,<addr-line>Bonn</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H. M." last="Van Deurzen">Carolien H. M. Van Deurzen</name><affiliation><nlm:aff id="af96"><addr-line>Department of Pathology</addr-line>,<institution>Erasmus University Medical Center</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation><nlm:aff id="af97"><addr-line>Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Kriege, Mieke" sort="Kriege, Mieke" uniqKey="Kriege M" first="Mieke" last="Kriege">Mieke Kriege</name><affiliation><nlm:aff id="af97"><addr-line>Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:aff id="af98"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="af98"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="af99"><addr-line>Department of Cancer Epidemiology and Prevention</addr-line>,<institution>M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="af100"><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name><affiliation><nlm:aff id="af101"><addr-line>Clinical Science Institute</addr-line>,<institution>University Hospital Galway</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country>,</nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="af101"><addr-line>Clinical Science Institute</addr-line>,<institution>University Hospital Galway</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country>,</nlm:aff></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation><nlm:aff id="af102"><addr-line>Department of Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af103"><addr-line>National Center for Tumor Diseases</addr-line>,<institution>University of Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Tapper, William J" sort="Tapper, William J" uniqKey="Tapper W" first="William J." last="Tapper">William J. Tapper</name><affiliation><nlm:aff id="af104"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Gerty, Susan M" sort="Gerty, Susan M" uniqKey="Gerty S" first="Susan M." last="Gerty">Susan M. Gerty</name><affiliation><nlm:aff id="af104"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Durcan, Lorraine" sort="Durcan, Lorraine" uniqKey="Durcan L" first="Lorraine" last="Durcan">Lorraine Durcan</name><affiliation><nlm:aff id="af104"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="af105"><addr-line>Anatomical Pathology</addr-line>,<institution>The Alfred Hospital</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="af81"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af106"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="af81"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af106"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos Santos Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="af107"><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="af67"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="af67"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Van T Veer, Laura J" sort="Van T Veer, Laura J" uniqKey="Van T Veer L" first="Laura J." last="Van'T Veer">Laura J. Van'T Veer</name><affiliation><nlm:aff id="af108"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Cornelissen, Sten" sort="Cornelissen, Sten" uniqKey="Cornelissen S" first="Sten" last="Cornelissen">Sten Cornelissen</name><affiliation><nlm:aff id="af108"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Forsti, Asta" sort="Forsti, Asta" uniqKey="Forsti A" first="Asta" last="Försti">Asta Försti</name><affiliation><nlm:aff id="af37"><addr-line>Division of Molecular Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af109"><addr-line>Center for Primary Health Care Research</addr-line>,<institution>University of Lund</institution>,<addr-line>Malmö</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation><nlm:aff id="af36"><addr-line>Molecular Genetics of Breast Cancer</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af110"><addr-line>Institute of Human Genetics</addr-line>,<institution>Pontificia University Javeriana</institution>,<addr-line>Bogota</addr-line>,<country>Colombia</country>,</nlm:aff></affiliation></author><author><name sortKey="Rudiger, Thomas" sort="Rudiger, Thomas" uniqKey="Rudiger T" first="Thomas" last="Rüdiger">Thomas Rüdiger</name><affiliation><nlm:aff id="af111"><addr-line>Institute of Pathology</addr-line>,<institution>Städtisches Klinikum Karlsruhe</institution>,<addr-line>Karlsruhe</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="af112"><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology</addr-line>,<institution>University Clinic Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Nickels, Stefan" sort="Nickels, Stefan" uniqKey="Nickels S" first="Stefan" last="Nickels">Stefan Nickels</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Weltens, Caroline" sort="Weltens, Caroline" uniqKey="Weltens C" first="Caroline" last="Weltens">Caroline Weltens</name><affiliation><nlm:aff id="af113"><institution>Universital Hospital Gasthuisberg</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation><nlm:aff id="af113"><institution>Universital Hospital Gasthuisberg</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation></author><author><name sortKey="Moisse, Matthieu" sort="Moisse, Matthieu" uniqKey="Moisse M" first="Matthieu" last="Moisse">Matthieu Moisse</name><affiliation><nlm:aff id="af114"><addr-line>Laboratory for Translational Genetics, Department of Oncology</addr-line>,<institution>University of Leuven</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af115"><institution>Vesalius Research Center (VRC), VIB</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Brown, Judith" sort="Brown, Judith" uniqKey="Brown J" first="Judith" last="Brown">Judith Brown</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="af77"><addr-line>Cancer Genomics Laboratory</addr-line>,<institution>Centre Hospitalier Universitaire de Québec Research Center and Laval University</institution>,<addr-line>Quebec City</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="af78"><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="af116"><institution>Beckman Research Institute of City of Hope</institution>,<addr-line>Duarte</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="af79"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia" sort="Bogdanova, Natalia" uniqKey="Bogdanova N" first="Natalia" last="Bogdanova">Natalia Bogdanova</name><affiliation><nlm:aff id="af117"><addr-line>Department of Radiation Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="af118"><addr-line>Department of Obstetrics and Gynaecology</addr-line>,<institution>Hannover Medical School</institution>,<addr-line>Hannover</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="af82"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center</addr-line>,<institution>Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff wicri:cut=" and" id="af119"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine</addr-line>,<institution>Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="af86"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="af86"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Devillee, Peter" sort="Devillee, Peter" uniqKey="Devillee P" first="Peter" last="Devillee">Peter Devillee</name><affiliation><nlm:aff id="af88"><addr-line>Department of Human Genetics & Department of Pathology</addr-line>,<institution>Leiden University Medical Center</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="af94"><institution>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>,<addr-line>Stuttgart</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af95"><institution>University of Tübingen</institution>,<addr-line>Tübingen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje" sort="Hooning, Maartje" uniqKey="Hooning M" first="Maartje" last="Hooning">Maartje Hooning</name><affiliation><nlm:aff id="af97"><addr-line>Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="af66"><addr-line>Breakthrough Breast Cancer Research Centre and Division of Breast Cancer Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name><affiliation><nlm:aff id="af120"><addr-line>Division of Cancer Studies</addr-line>,<institution>Kings College London, Guy’s Hospital</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="af102"><addr-line>Department of Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af39"><addr-line>Molecular Epidemiology Group</addr-line>,<institution>German Cancer Research Center (DKFZ)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Marmee, Frederick" sort="Marmee, Frederick" uniqKey="Marmee F" first="Frederick" last="Marmee">Frederick Marmee</name><affiliation><nlm:aff id="af102"><addr-line>Department of Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af103"><addr-line>National Center for Tumor Diseases</addr-line>,<institution>University of Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name><affiliation><nlm:aff id="af104"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="af81"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af106"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="af107"><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka" sort="Schmidt, Marjanka" uniqKey="Schmidt M" first="Marjanka" last="Schmidt">Marjanka Schmidt</name><affiliation><nlm:aff id="af108"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="af108"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="af36"><addr-line>Molecular Genetics of Breast Cancer</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="af114"><addr-line>Laboratory for Translational Genetics, Department of Oncology</addr-line>,<institution>University of Leuven</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af115"><institution>Vesalius Research Center (VRC), VIB</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas" sort="Easton, Douglas" uniqKey="Easton D" first="Douglas" last="Easton">Douglas Easton</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V. Shane" last="Pankratz">V. Shane Pankratz</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine M" sort="Vachon, Celine M" uniqKey="Vachon C" first="Celine M." last="Vachon">Celine M. Vachon</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Laboratory Medicine and Pathology</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24927736</idno><idno type="pmc">4204763</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204763</idno><idno type="RBID">PMC:4204763</idno><idno type="doi">10.1093/hmg/ddu300</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001873</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001873</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade</title><author><name sortKey="Purrington, Kristen S" sort="Purrington, Kristen S" uniqKey="Purrington K" first="Kristen S." last="Purrington">Kristen S. Purrington</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Oncology</addr-line>,<institution>Wayne State University School of Medicine and Karmanos Cancer Institute</institution>,<addr-line>Detroit</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Slettedahl, Seth" sort="Slettedahl, Seth" uniqKey="Slettedahl S" first="Seth" last="Slettedahl">Seth Slettedahl</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="af9"><addr-line>Department of Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="af13"><addr-line>Copenhagen General Population Study</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af14"><addr-line>Department of Clinical Biochemistry</addr-line>,<institution>Herlev Hospital, Copenhagen University Hospital, University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="af15"><addr-line>Ontario Cancer Genetics Network</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af18"><addr-line>Department of Molecular Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="af21"><addr-line>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Carpenter, Jane" sort="Carpenter, Jane" uniqKey="Carpenter J" first="Jane" last="Carpenter">Jane Carpenter</name><affiliation><nlm:aff id="af23"><addr-line>Australian Breast Cancer Tissue Bank</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation><nlm:aff id="af25"><addr-line>Molecular Diagnostics Laboratory INRASTES</addr-line>,<institution>National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="af26"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="af27"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af30"><addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology</addr-line>,<institution>University of California at Los Angeles</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="af31"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af32"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="af34"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu</addr-line>,<institution>University of Oulu, Oulu University Hospital/NordLab Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="af35"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af40"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="af7"><addr-line>Department of Molecular Medicine and Surgery</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="af41"><addr-line>Department of Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="af43"><addr-line>Human Genetics Group, Human Cancer Genetics Program</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af44"><addr-line>Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="af45"><addr-line>Division of Genetics and Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af46"><addr-line>Division of Breast Cancer Research</addr-line>,<institution>Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="af47"><addr-line>Department of Genetics, Institute for Cancer Research</addr-line>,<institution>Oslo University Hospital, Radiumhospitalet</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af48"><addr-line>Faculty of Medicine (Faculty Division Ahus)</addr-line>,<institution>University of Oslo (UiO)</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country>,</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="af49"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018</addr-line>,<institution>Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af50"><institution>University Paris-Sud, UMRS 1018</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="af51"><addr-line>Division of Gynaecology and Obstetrics</addr-line>,<institution>Technische Universität München</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Fagerholm, Rainer" sort="Fagerholm, Rainer" uniqKey="Fagerholm R" first="Rainer" last="Fagerholm">Rainer Fagerholm</name><affiliation><nlm:aff id="af10"><addr-line>Department of Obstetrics and Gynecology, Oncology and Clinical Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="af11"><addr-line>Department of Clinical Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="af12"><addr-line>Department of Oncology</addr-line>,<institution>University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="af14"><addr-line>Department of Clinical Biochemistry</addr-line>,<institution>Herlev Hospital, Copenhagen University Hospital, University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="af13"><addr-line>Copenhagen General Population Study</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="af52"><addr-line>Department of Breast Surgery, Herlev Hospital</addr-line>,<institution>Copenhagen University Hospital</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="af2"><addr-line>Department of Laboratory Medicine and Pathology</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Olswold, Curtis" sort="Olswold, Curtis" uniqKey="Olswold C" first="Curtis" last="Olswold">Curtis Olswold</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="af19"><addr-line>Department of Laboratory Medicine and Pathobiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af53"><addr-line>Laboratory Medicine Program</addr-line>,<institution>University Health Network</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="af16"><addr-line>Prosserman Centre for Health Research</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af20"><addr-line>Division of Epidemiology, Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name><affiliation><nlm:aff id="af17"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="af21"><addr-line>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="af22"><addr-line>Academic Unit of Pathology, Department of Neuroscience</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="af54"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="af54"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="af6"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Clarke, Christine" sort="Clarke, Christine" uniqKey="Clarke C" first="Christine" last="Clarke">Christine Clarke</name><affiliation><nlm:aff id="af24"><addr-line>Westmead Institute for Cancer Research, Sydney Medical School Westmead</addr-line>,<institution>University of Sydney at the Westmead Millennium Institute</institution>,<addr-line>Westmead</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Scott, Rodney" sort="Scott, Rodney" uniqKey="Scott R" first="Rodney" last="Scott">Rodney Scott</name><affiliation><nlm:aff id="af55"><addr-line>Division of Genetics</addr-line>,<institution>Hunter Area Pathology Service and University of Newcastle</institution>,<addr-line>Newcastle</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation><nlm:aff id="af25"><addr-line>Molecular Diagnostics Laboratory INRASTES</addr-line>,<institution>National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</nlm:aff></affiliation></author><author><name sortKey="Fountzilas, George" sort="Fountzilas, George" uniqKey="Fountzilas G" first="George" last="Fountzilas">George Fountzilas</name><affiliation><nlm:aff id="af56"><addr-line>Department of Medical Oncology, “Papageorgiou” Hospital</addr-line>,<institution>Aristotle University of Thessaloniki School of Medicine</institution>,<addr-line>Thessaloniki</addr-line>,<country>Greece</country>,</nlm:aff></affiliation></author><author><name sortKey="Konstantopoulou, Irene" sort="Konstantopoulou, Irene" uniqKey="Konstantopoulou I" first="Irene" last="Konstantopoulou">Irene Konstantopoulou</name><affiliation><nlm:aff id="af25"><addr-line>Molecular Diagnostics Laboratory INRASTES</addr-line>,<institution>National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="af26"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation><nlm:aff id="af26"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="af57"><addr-line>Epidemiology Program, Cancer Research Center</addr-line>,<institution>University of Hawaii</institution>,<addr-line>Honolulu</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="af28"><addr-line>Institute of Human Genetics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Hartmann, Arndt" sort="Hartmann, Arndt" uniqKey="Hartmann A" first="Arndt" last="Hartmann">Arndt Hartmann</name><affiliation><nlm:aff id="af29"><addr-line>Institute of Pathology</addr-line>,<institution>University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="af27"><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="af31"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af32"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="af31"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af32"><addr-line>Imaging Center, Department of Clinical Pathology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="af31"><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af33"><addr-line>Cancer Center</addr-line>,<institution>Kuopio University Hospital</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="af58"><addr-line>Department of Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="af34"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu</addr-line>,<institution>University of Oulu, Oulu University Hospital/NordLab Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Kauppila, Saila" sort="Kauppila, Saila" uniqKey="Kauppila S" first="Saila" last="Kauppila">Saila Kauppila</name><affiliation><nlm:aff id="af59"><addr-line>Department of Pathology</addr-line>,<institution>Oulu University Hospital, University of Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation><nlm:aff id="af35"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af40"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="af60"><institution>Saarland Cancer Registry</institution>,<addr-line>Saarbrücken</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="af35"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="af8"><addr-line>Department of Oncology–Pathology</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Balleine, Rosemary" sort="Balleine, Rosemary" uniqKey="Balleine R" first="Rosemary" last="Balleine">Rosemary Balleine</name><affiliation><nlm:aff id="af62"><institution>Westmead Millenium Institute for Medical Research</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Perez">Jose Ignacio Arias Perez</name><affiliation><nlm:aff id="af63"><addr-line>Servicio de Cirugía General y Especialidades</addr-line>,<institution>Hospital Monte Naranco</institution>,<addr-line>Oviedo</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Pilar Zamora, M" sort="Pilar Zamora, M" uniqKey="Pilar Zamora M" first="M." last="Pilar Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="af65"><addr-line>Servicio de Oncología Médica</addr-line>,<institution>Hospital Universitario La Paz</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Menendez, Primitiva" sort="Menendez, Primitiva" uniqKey="Menendez P" first="Primitiva" last="Menéndez">Primitiva Menéndez</name><affiliation><nlm:aff id="af64"><addr-line>Servicio de Anatomía Patológica</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="af66"><addr-line>Breakthrough Breast Cancer Research Centre and Division of Breast Cancer Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation><nlm:aff id="af45"><addr-line>Division of Genetics and Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="af66"><addr-line>Breakthrough Breast Cancer Research Centre and Division of Breast Cancer Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Arveux, Patrick" sort="Arveux, Patrick" uniqKey="Arveux P" first="Patrick" last="Arveux">Patrick Arveux</name><affiliation><nlm:aff id="af68"><addr-line>Center Georges-Francois Leclerc</addr-line>,<institution>Registry of Gynecologic Tumors</institution>,<addr-line>Dijon</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Kerbrat, Pierre" sort="Kerbrat, Pierre" uniqKey="Kerbrat P" first="Pierre" last="Kerbrat">Pierre Kerbrat</name><affiliation><nlm:aff id="af69"><institution>Centre Eugène Marquis, Department of Medical Oncology</institution>,<addr-line>Rennes</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="af49"><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018</addr-line>,<institution>Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af50"><institution>University Paris-Sud, UMRS 1018</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Bugert, Peter" sort="Bugert, Peter" uniqKey="Bugert P" first="Peter" last="Bugert">Peter Bugert</name><affiliation><nlm:aff id="af70"><institution>German Red Cross Blood Service of Baden-Württemberg-Hessen</institution>,<addr-line>Mannheim</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af71"><addr-line>Medical Faculty Mannheim, Institute of Transfusion Medicine and Immunology</addr-line>,<institution>Heidelberg University</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="af72"><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center</addr-line>,<institution>The Ohio State University</institution>,<addr-line>Columbus</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B." last="Ambrosone">Christine B. Ambrosone</name><affiliation><nlm:aff id="af73"><institution>Roswell Park Cancer Institute</institution>,<addr-line>Buffalo</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Labreche, France" sort="Labreche, France" uniqKey="Labreche F" first="France" last="Labrèche">France Labrèche</name><affiliation><nlm:aff id="af74"><addr-line>Department of Environmental & Occupational Health and of Social & Preventive Medicine</addr-line>,<institution>School of Public Health, Université de Montréal</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name><affiliation><nlm:aff id="af75"><addr-line>Department of Medicine</addr-line>,<institution>McGill University</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af76"><addr-line>Division of Clinical Epidemiology</addr-line>,<institution>McGill University Health Centre, Royal Victoria Hospital</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="af77"><addr-line>Cancer Genomics Laboratory</addr-line>,<institution>Centre Hospitalier Universitaire de Québec Research Center and Laval University</institution>,<addr-line>Quebec City</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation><nlm:aff id="af78"><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lee, Eunjung" sort="Lee, Eunjung" uniqKey="Lee E" first="Eunjung" last="Lee">Eunjung Lee</name><affiliation><nlm:aff id="af26"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Dite, Gillian S" sort="Dite, Gillian S" uniqKey="Dite G" first="Gillian S." last="Dite">Gillian S. Dite</name><affiliation><nlm:aff id="af79"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="af79"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="af80"><addr-line>Department of Pathology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="af82"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center</addr-line>,<institution>Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Martha" sort="Shrubsole, Martha" uniqKey="Shrubsole M" first="Martha" last="Shrubsole">Martha Shrubsole</name><affiliation><nlm:aff id="af72"><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center</addr-line>,<institution>The Ohio State University</institution>,<addr-line>Columbus</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Deming Halverson, Sandra" sort="Deming Halverson, Sandra" uniqKey="Deming Halverson S" first="Sandra" last="Deming-Halverson">Sandra Deming-Halverson</name><affiliation><nlm:aff id="af82"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center</addr-line>,<institution>Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ficarazzi, Filomena" sort="Ficarazzi, Filomena" uniqKey="Ficarazzi F" first="Filomena" last="Ficarazzi">Filomena Ficarazzi</name><affiliation><nlm:aff id="af83"><institution>Cogentech Cancer Genetic Test Laboratory</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af84"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><affiliation><nlm:aff id="af85"><addr-line>Division of Cancer Prevention and Genetics</addr-line>,<institution>Istituto Europeo di Oncologia (IEO)</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="af84"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="af86"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name><affiliation><nlm:aff id="af86"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="af87"><addr-line>Department of Surgical Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="af89"><addr-line>Family Cancer Clinic, Department of Medical Oncology</addr-line>,<institution>Erasmus MC-Daniel den Hoed Cancer Centrer</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="af90"><institution>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)</institution>,<addr-line>Bochum</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation><nlm:aff id="af91"><addr-line>Department of Internal Medicine</addr-line>,<institution>Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus</institution>,<addr-line>Bonn</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H. M." last="Van Deurzen">Carolien H. M. Van Deurzen</name><affiliation><nlm:aff id="af96"><addr-line>Department of Pathology</addr-line>,<institution>Erasmus University Medical Center</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation><nlm:aff id="af97"><addr-line>Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Kriege, Mieke" sort="Kriege, Mieke" uniqKey="Kriege M" first="Mieke" last="Kriege">Mieke Kriege</name><affiliation><nlm:aff id="af97"><addr-line>Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:aff id="af98"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="af98"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="af99"><addr-line>Department of Cancer Epidemiology and Prevention</addr-line>,<institution>M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="af100"><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name><affiliation><nlm:aff id="af101"><addr-line>Clinical Science Institute</addr-line>,<institution>University Hospital Galway</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country>,</nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="af101"><addr-line>Clinical Science Institute</addr-line>,<institution>University Hospital Galway</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country>,</nlm:aff></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation><nlm:aff id="af102"><addr-line>Department of Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af103"><addr-line>National Center for Tumor Diseases</addr-line>,<institution>University of Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Tapper, William J" sort="Tapper, William J" uniqKey="Tapper W" first="William J." last="Tapper">William J. Tapper</name><affiliation><nlm:aff id="af104"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Gerty, Susan M" sort="Gerty, Susan M" uniqKey="Gerty S" first="Susan M." last="Gerty">Susan M. Gerty</name><affiliation><nlm:aff id="af104"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Durcan, Lorraine" sort="Durcan, Lorraine" uniqKey="Durcan L" first="Lorraine" last="Durcan">Lorraine Durcan</name><affiliation><nlm:aff id="af104"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="af105"><addr-line>Anatomical Pathology</addr-line>,<institution>The Alfred Hospital</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="af81"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af106"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="af81"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af106"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos Santos Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="af107"><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="af67"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="af67"><addr-line>Breakthrough Breast Cancer Research Centre</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Van T Veer, Laura J" sort="Van T Veer, Laura J" uniqKey="Van T Veer L" first="Laura J." last="Van'T Veer">Laura J. Van'T Veer</name><affiliation><nlm:aff id="af108"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Cornelissen, Sten" sort="Cornelissen, Sten" uniqKey="Cornelissen S" first="Sten" last="Cornelissen">Sten Cornelissen</name><affiliation><nlm:aff id="af108"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Forsti, Asta" sort="Forsti, Asta" uniqKey="Forsti A" first="Asta" last="Försti">Asta Försti</name><affiliation><nlm:aff id="af37"><addr-line>Division of Molecular Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af109"><addr-line>Center for Primary Health Care Research</addr-line>,<institution>University of Lund</institution>,<addr-line>Malmö</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation><nlm:aff id="af36"><addr-line>Molecular Genetics of Breast Cancer</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af110"><addr-line>Institute of Human Genetics</addr-line>,<institution>Pontificia University Javeriana</institution>,<addr-line>Bogota</addr-line>,<country>Colombia</country>,</nlm:aff></affiliation></author><author><name sortKey="Rudiger, Thomas" sort="Rudiger, Thomas" uniqKey="Rudiger T" first="Thomas" last="Rüdiger">Thomas Rüdiger</name><affiliation><nlm:aff id="af111"><addr-line>Institute of Pathology</addr-line>,<institution>Städtisches Klinikum Karlsruhe</institution>,<addr-line>Karlsruhe</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="af112"><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology</addr-line>,<institution>University Clinic Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Nickels, Stefan" sort="Nickels, Stefan" uniqKey="Nickels S" first="Stefan" last="Nickels">Stefan Nickels</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Weltens, Caroline" sort="Weltens, Caroline" uniqKey="Weltens C" first="Caroline" last="Weltens">Caroline Weltens</name><affiliation><nlm:aff id="af113"><institution>Universital Hospital Gasthuisberg</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation><nlm:aff id="af113"><institution>Universital Hospital Gasthuisberg</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation></author><author><name sortKey="Moisse, Matthieu" sort="Moisse, Matthieu" uniqKey="Moisse M" first="Matthieu" last="Moisse">Matthieu Moisse</name><affiliation><nlm:aff id="af114"><addr-line>Laboratory for Translational Genetics, Department of Oncology</addr-line>,<institution>University of Leuven</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af115"><institution>Vesalius Research Center (VRC), VIB</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Brown, Judith" sort="Brown, Judith" uniqKey="Brown J" first="Judith" last="Brown">Judith Brown</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="af77"><addr-line>Cancer Genomics Laboratory</addr-line>,<institution>Centre Hospitalier Universitaire de Québec Research Center and Laval University</institution>,<addr-line>Quebec City</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="af78"><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="af116"><institution>Beckman Research Institute of City of Hope</institution>,<addr-line>Duarte</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="af79"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia" sort="Bogdanova, Natalia" uniqKey="Bogdanova N" first="Natalia" last="Bogdanova">Natalia Bogdanova</name><affiliation><nlm:aff id="af117"><addr-line>Department of Radiation Oncology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="af118"><addr-line>Department of Obstetrics and Gynaecology</addr-line>,<institution>Hannover Medical School</institution>,<addr-line>Hannover</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="af82"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center</addr-line>,<institution>Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff wicri:cut=" and" id="af119"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine</addr-line>,<institution>Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="af86"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="af86"><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Devillee, Peter" sort="Devillee, Peter" uniqKey="Devillee P" first="Peter" last="Devillee">Peter Devillee</name><affiliation><nlm:aff id="af88"><addr-line>Department of Human Genetics & Department of Pathology</addr-line>,<institution>Leiden University Medical Center</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="af94"><institution>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>,<addr-line>Stuttgart</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af95"><institution>University of Tübingen</institution>,<addr-line>Tübingen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje" sort="Hooning, Maartje" uniqKey="Hooning M" first="Maartje" last="Hooning">Maartje Hooning</name><affiliation><nlm:aff id="af97"><addr-line>Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="af66"><addr-line>Breakthrough Breast Cancer Research Centre and Division of Breast Cancer Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name><affiliation><nlm:aff id="af120"><addr-line>Division of Cancer Studies</addr-line>,<institution>Kings College London, Guy’s Hospital</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="af102"><addr-line>Department of Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af39"><addr-line>Molecular Epidemiology Group</addr-line>,<institution>German Cancer Research Center (DKFZ)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Marmee, Frederick" sort="Marmee, Frederick" uniqKey="Marmee F" first="Frederick" last="Marmee">Frederick Marmee</name><affiliation><nlm:aff id="af102"><addr-line>Department of Obstetrics and Gynecology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af103"><addr-line>National Center for Tumor Diseases</addr-line>,<institution>University of Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name><affiliation><nlm:aff id="af104"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="af81"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af106"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="af107"><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka" sort="Schmidt, Marjanka" uniqKey="Schmidt M" first="Marjanka" last="Schmidt">Marjanka Schmidt</name><affiliation><nlm:aff id="af108"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="af108"><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="af36"><addr-line>Molecular Genetics of Breast Cancer</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="af38"><addr-line>Division of Cancer Epidemiology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="af114"><addr-line>Laboratory for Translational Genetics, Department of Oncology</addr-line>,<institution>University of Leuven</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af115"><institution>Vesalius Research Center (VRC), VIB</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas" sort="Easton, Douglas" uniqKey="Easton D" first="Douglas" last="Easton">Douglas Easton</name><affiliation><nlm:aff id="af4"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V. Shane" last="Pankratz">V. Shane Pankratz</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine M" sort="Vachon, Celine M" uniqKey="Vachon C" first="Celine M." last="Vachon">Celine M. Vachon</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="af1"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Laboratory Medicine and Pathology</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author></analytic><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Mitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. Several small candidate gene studies have reported associations between variation in mitotic genes and breast cancer risk. We measured associations between 2156 single nucleotide polymorphisms (SNPs) from 194 mitotic genes and breast cancer risk, overall and by histologic grade, in the Breast Cancer Association Consortium (BCAC) iCOGS study (<italic>n</italic> = 39 067 cases; <italic>n</italic> = 42 106 controls). SNPs in <italic>TACC2</italic> [rs17550038: odds ratio (OR) = 1.24, 95% confidence interval (CI) 1.16–1.33, <italic>P</italic> = 4.2 × 10<sup>−10</sup>) and <italic>EIF3H</italic> (rs799890: OR = 1.07, 95% CI 1.04–1.11, <italic>P</italic> = 8.7 × 10<sup>−6</sup>) were significantly associated with risk of low-grade breast cancer. The <italic>TACC2</italic> signal was retained (rs17550038: OR = 1.15, 95% CI 1.07–1.23, <italic>P</italic> = 7.9 × 10<sup>−5</sup>) after adjustment for breast cancer risk SNPs in the nearby <italic>FGFR2</italic> gene, suggesting that <italic>TACC2</italic> is a novel, independent genome-wide significant genetic risk locus for low-grade breast cancer. While no SNPs were individually associated with high-grade disease, a pathway-level gene set analysis showed that variation across the 194 mitotic genes was associated with high-grade breast cancer risk (<italic>P</italic> = 2.1 × 10<sup>−3</sup>). These observations will provide insight into the contribution of mitotic defects to histological grade and the etiology of breast cancer.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Mol Genet</journal-id><journal-id journal-id-type="iso-abbrev">Hum. Mol. Genet</journal-id><journal-id journal-id-type="publisher-id">hmg</journal-id><journal-id journal-id-type="hwp">hmg</journal-id><journal-title-group><journal-title>Human Molecular Genetics</journal-title></journal-title-group><issn pub-type="ppub">0964-6906</issn><issn pub-type="epub">1460-2083</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24927736</article-id><article-id pub-id-type="pmc">4204763</article-id><article-id pub-id-type="doi">10.1093/hmg/ddu300</article-id><article-id pub-id-type="publisher-id">ddu300</article-id><article-categories><subj-group subj-group-type="heading"><subject>Association Studies Articles</subject></subj-group></article-categories><title-group><article-title>Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade</article-title></title-group><contrib-group><contrib 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rid="af109">109</xref></contrib><contrib contrib-type="author"><name><surname>Torres</surname><given-names>Diana</given-names></name><xref ref-type="aff" rid="af36">36</xref><xref ref-type="aff" rid="af110">110</xref></contrib><contrib contrib-type="author"><name><surname>Rüdiger</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="af111">111</xref></contrib><contrib contrib-type="author"><name><surname>Rudolph</surname><given-names>Anja</given-names></name><xref ref-type="aff" rid="af38">38</xref></contrib><contrib contrib-type="author"><name><surname>Flesch-Janys</surname><given-names>Dieter</given-names></name><xref ref-type="aff" rid="af112">112</xref></contrib><contrib contrib-type="author"><name><surname>Nickels</surname><given-names>Stefan</given-names></name><xref ref-type="aff" rid="af38">38</xref></contrib><contrib contrib-type="author"><name><surname>Weltens</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="af113">113</xref></contrib><contrib contrib-type="author"><name><surname>Floris</surname><given-names>Giuseppe</given-names></name><xref ref-type="aff" rid="af113">113</xref></contrib><contrib contrib-type="author"><name><surname>Moisse</surname><given-names>Matthieu</given-names></name><xref ref-type="aff" rid="af114">114</xref><xref ref-type="aff" rid="af115">115</xref></contrib><contrib contrib-type="author"><name><surname>Dennis</surname><given-names>Joe</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Qin</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M.</given-names></name><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Shah</surname><given-names>Mitul</given-names></name><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Brown</surname><given-names>Judith</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Simard</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="af77">77</xref></contrib><contrib contrib-type="author"><name><surname>Anton-Culver</surname><given-names>Hoda</given-names></name><xref ref-type="aff" rid="af78">78</xref></contrib><contrib contrib-type="author"><name><surname>Neuhausen</surname><given-names>Susan L.</given-names></name><xref ref-type="aff" rid="af116">116</xref></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John L.</given-names></name><xref ref-type="aff" rid="af79">79</xref></contrib><contrib contrib-type="author"><name><surname>Bogdanova</surname><given-names>Natalia</given-names></name><xref ref-type="aff" rid="af117">117</xref></contrib><contrib contrib-type="author"><name><surname>Dörk</surname><given-names>Thilo</given-names></name><xref ref-type="aff" rid="af118">118</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Wei</given-names></name><xref ref-type="aff" rid="af82">82</xref></contrib><contrib contrib-type="author"><name><surname>Radice</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="af119">119</xref></contrib><contrib contrib-type="author"><name><surname>Jakubowska</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="af86">86</xref></contrib><contrib contrib-type="author"><name><surname>Lubinski</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="af86">86</xref></contrib><contrib contrib-type="author"><name><surname>Devillee</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="af88">88</xref></contrib><contrib contrib-type="author"><name><surname>Brauch</surname><given-names>Hiltrud</given-names></name><xref ref-type="aff" rid="af94">94</xref><xref ref-type="aff" rid="af95">95</xref></contrib><contrib contrib-type="author"><name><surname>Hooning</surname><given-names>Maartje</given-names></name><xref ref-type="aff" rid="af97">97</xref></contrib><contrib contrib-type="author"><name><surname>García-Closas</surname><given-names>Montserrat</given-names></name><xref ref-type="aff" rid="af66">66</xref></contrib><contrib contrib-type="author"><name><surname>Sawyer</surname><given-names>Elinor</given-names></name><xref ref-type="aff" rid="af120">120</xref></contrib><contrib contrib-type="author"><name><surname>Burwinkel</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="af102">102</xref><xref ref-type="aff" rid="af39">39</xref></contrib><contrib contrib-type="author"><name><surname>Marmee</surname><given-names>Frederick</given-names></name><xref ref-type="aff" rid="af102">102</xref><xref ref-type="aff" rid="af103">103</xref></contrib><contrib contrib-type="author"><name><surname>Eccles</surname><given-names>Diana M.</given-names></name><xref ref-type="aff" rid="af104">104</xref></contrib><contrib contrib-type="author"><name><surname>Giles</surname><given-names>Graham G.</given-names></name><xref ref-type="aff" rid="af81">81</xref><xref ref-type="aff" rid="af106">106</xref></contrib><contrib contrib-type="author"><name><surname>Peto</surname><given-names>Julian</given-names></name><xref ref-type="aff" rid="af107">107</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Marjanka</given-names></name><xref ref-type="aff" rid="af108">108</xref></contrib><contrib contrib-type="author"><name><surname>Broeks</surname><given-names>Annegien</given-names></name><xref ref-type="aff" rid="af108">108</xref></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name><xref ref-type="aff" rid="af36">36</xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><xref ref-type="aff" rid="af38">38</xref></contrib><contrib contrib-type="author"><name><surname>Lambrechts</surname><given-names>Diether</given-names></name><xref ref-type="aff" rid="af114">114</xref><xref ref-type="aff" rid="af115">115</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul D.P.</given-names></name><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas</given-names></name><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Pankratz</surname><given-names>V. Shane</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Slager</surname><given-names>Susan</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Vachon</surname><given-names>Celine M.</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus J.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><aff id="af1"><label>1</label><addr-line>Department of Health Sciences Research</addr-line>,</aff><aff id="af2"><label>2</label><addr-line>Department of Laboratory Medicine and Pathology</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester</addr-line>,<country>USA</country>,</aff><aff id="af3"><label>3</label><addr-line>Department of Oncology</addr-line>,<institution>Wayne State University School of Medicine and Karmanos Cancer Institute</institution>,<addr-line>Detroit</addr-line>,<country>USA</country>,</aff><aff id="af4"><label>4</label><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line>,</aff><aff id="af5"><label>5</label><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</aff><aff id="af6"><label>6</label><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,</aff><aff id="af7"><label>7</label><addr-line>Department of Molecular Medicine and Surgery</addr-line>,</aff><aff id="af8"><label>8</label><addr-line>Department of Oncology–Pathology</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</aff><aff id="af9"><label>9</label><addr-line>Department of Obstetrics and Gynecology</addr-line>,</aff><aff id="af10"><label>10</label><addr-line>Department of Obstetrics and Gynecology, Oncology and Clinical Genetics</addr-line>,</aff><aff id="af11"><label>11</label><addr-line>Department of Clinical Genetics</addr-line>,</aff><aff id="af12"><label>12</label><addr-line>Department of Oncology</addr-line>,<institution>University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</aff><aff id="af13"><label>13</label><addr-line>Copenhagen General Population Study</addr-line>,</aff><aff id="af14"><label>14</label><addr-line>Department of Clinical Biochemistry</addr-line>,<institution>Herlev Hospital, Copenhagen University Hospital, University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</aff><aff id="af15"><label>15</label><addr-line>Ontario Cancer Genetics Network</addr-line>,</aff><aff id="af16"><label>16</label><addr-line>Prosserman Centre for Health Research</addr-line>,</aff><aff id="af17"><label>17</label><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</aff><aff id="af18"><label>18</label><addr-line>Department of Molecular Genetics</addr-line>,</aff><aff id="af19"><label>19</label><addr-line>Department of Laboratory Medicine and Pathobiology</addr-line>,</aff><aff id="af20"><label>20</label><addr-line>Division of Epidemiology, Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</aff><aff id="af21"><label>21</label><addr-line>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology</addr-line>,</aff><aff id="af22"><label>22</label><addr-line>Academic Unit of Pathology, Department of Neuroscience</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country>,</aff><aff id="af23"><label>23</label><addr-line>Australian Breast Cancer Tissue Bank</addr-line>,</aff><aff id="af24"><label>24</label><addr-line>Westmead Institute for Cancer Research, Sydney Medical School Westmead</addr-line>,<institution>University of Sydney at the Westmead Millennium Institute</institution>,<addr-line>Westmead</addr-line>,<country>Australia</country>,</aff><aff id="af25"><label>25</label><addr-line>Molecular Diagnostics Laboratory INRASTES</addr-line>,<institution>National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Athens</addr-line>,<country>Greece</country>,</aff><aff id="af26"><label>26</label><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>,<institution>University of Southern California</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</aff><aff id="af27"><label>27</label><addr-line>University Breast Center Franconia, Department of Gynecology and Obstetrics</addr-line>,</aff><aff id="af28"><label>28</label><addr-line>Institute of Human Genetics</addr-line>,</aff><aff id="af29"><label>29</label><addr-line>Institute of Pathology</addr-line>,<institution>University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country>,</aff><aff id="af30"><label>30</label><addr-line>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology</addr-line>,<institution>University of California at Los Angeles</institution>,<addr-line>Los Angeles</addr-line>,<country>USA</country>,</aff><aff id="af31"><label>31</label><addr-line>School of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland</addr-line>,<institution>University of Eastern Finland</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</aff><aff id="af32"><label>32</label><addr-line>Imaging Center, Department of Clinical Pathology</addr-line>,</aff><aff id="af33"><label>33</label><addr-line>Cancer Center</addr-line>,<institution>Kuopio University Hospital</institution>,<addr-line>Kuopio</addr-line>,<country>Finland</country>,</aff><aff id="af34"><label>34</label><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu</addr-line>,<institution>University of Oulu, Oulu University Hospital/NordLab Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</aff><aff id="af35"><label>35</label><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line>,</aff><aff id="af36"><label>36</label><addr-line>Molecular Genetics of Breast Cancer</addr-line>,</aff><aff id="af37"><label>37</label><addr-line>Division of Molecular Genetic Epidemiology</addr-line>,</aff><aff id="af38"><label>38</label><addr-line>Division of Cancer Epidemiology</addr-line>,</aff><aff id="af39"><label>39</label><addr-line>Molecular Epidemiology Group</addr-line>,<institution>German Cancer Research Center (DKFZ)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="af40"><label>40</label><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="af41"><label>41</label><addr-line>Department of Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country>,</aff><aff id="af42"><label>42</label><institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country>,</aff><aff id="af43"><label>43</label><addr-line>Human Genetics Group, Human Cancer Genetics Program</addr-line>,<institution>Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country>,</aff><aff id="af44"><label>44</label><addr-line>Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia</addr-line>,<country>Spain</country>,</aff><aff id="af45"><label>45</label><addr-line>Division of Genetics and Epidemiology</addr-line>,</aff><aff id="af46"><label>46</label><addr-line>Division of Breast Cancer Research</addr-line>,<institution>Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country>,</aff><aff id="af47"><label>47</label><addr-line>Department of Genetics, Institute for Cancer Research</addr-line>,<institution>Oslo University Hospital, Radiumhospitalet</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country>,</aff><aff id="af48"><label>48</label><addr-line>Faculty of Medicine (Faculty Division Ahus)</addr-line>,<institution>University of Oslo (UiO)</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country>,</aff><aff id="af49"><label>49</label><addr-line>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018</addr-line>,<institution>Environmental Epidemiology of Cancer</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</aff><aff id="af50"><label>50</label><institution>University Paris-Sud, UMRS 1018</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</aff><aff id="af51"><label>51</label><addr-line>Division of Gynaecology and Obstetrics</addr-line>,<institution>Technische Universität München</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</aff><aff id="af52"><label>52</label><addr-line>Department of Breast Surgery, Herlev Hospital</addr-line>,<institution>Copenhagen University Hospital</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</aff><aff id="af53"><label>53</label><addr-line>Laboratory Medicine Program</addr-line>,<institution>University Health Network</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country>,</aff><aff id="af54"><label>54</label><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</aff><aff id="af55"><label>55</label><addr-line>Division of Genetics</addr-line>,<institution>Hunter Area Pathology Service and University of Newcastle</institution>,<addr-line>Newcastle</addr-line>,<country>Australia</country>,</aff><aff id="af56"><label>56</label><addr-line>Department of Medical Oncology, “Papageorgiou” Hospital</addr-line>,<institution>Aristotle University of Thessaloniki School of Medicine</institution>,<addr-line>Thessaloniki</addr-line>,<country>Greece</country>,</aff><aff id="af57"><label>57</label><addr-line>Epidemiology Program, Cancer Research Center</addr-line>,<institution>University of Hawaii</institution>,<addr-line>Honolulu</addr-line>,<country>USA</country>,</aff><aff id="af58"><label>58</label><addr-line>Department of Oncology</addr-line>,</aff><aff id="af59"><label>59</label><addr-line>Department of Pathology</addr-line>,<institution>Oulu University Hospital, University of Oulu</institution>,<addr-line>Oulu</addr-line>,<country>Finland</country>,</aff><aff id="af60"><label>60</label><institution>Saarland Cancer Registry</institution>,<addr-line>Saarbrücken</addr-line>,<country>Germany</country>,</aff><aff id="af61"><label>61</label><institution>Peter MacCallum Cancer Center</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</aff><aff id="af62"><label>62</label><institution>Westmead Millenium Institute for Medical Research</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country>,</aff><aff id="af63"><label>63</label><addr-line>Servicio de Cirugía General y Especialidades</addr-line>,<institution>Hospital Monte Naranco</institution>,<addr-line>Oviedo</addr-line>,<country>Spain</country>,</aff><aff id="af64"><label>64</label><addr-line>Servicio de Anatomía Patológica</addr-line>,</aff><aff id="af65"><label>65</label><addr-line>Servicio de Oncología Médica</addr-line>,<institution>Hospital Universitario La Paz</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country>,</aff><aff id="af66"><label>66</label><addr-line>Breakthrough Breast Cancer Research Centre and Division of Breast Cancer Research</addr-line>,</aff><aff id="af67"><label>67</label><addr-line>Breakthrough Breast Cancer Research Centre</addr-line>,<institution>The Institute of Cancer Research</institution>,<addr-line>London</addr-line>,<country>UK</country>,</aff><aff id="af68"><label>68</label><addr-line>Center Georges-Francois Leclerc</addr-line>,<institution>Registry of Gynecologic Tumors</institution>,<addr-line>Dijon</addr-line>,<country>France</country>,</aff><aff id="af69"><label>69</label><institution>Centre Eugène Marquis, Department of Medical Oncology</institution>,<addr-line>Rennes</addr-line>,<country>France</country>,</aff><aff id="af70"><label>70</label><institution>German Red Cross Blood Service of Baden-Württemberg-Hessen</institution>,<addr-line>Mannheim</addr-line>,<country>Germany</country>,</aff><aff id="af71"><label>71</label><addr-line>Medical Faculty Mannheim, Institute of Transfusion Medicine and Immunology</addr-line>,<institution>Heidelberg University</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="af72"><label>72</label><addr-line>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center</addr-line>,<institution>The Ohio State University</institution>,<addr-line>Columbus</addr-line>,<country>USA</country>,</aff><aff id="af73"><label>73</label><institution>Roswell Park Cancer Institute</institution>,<addr-line>Buffalo</addr-line>,<country>USA</country>,</aff><aff id="af74"><label>74</label><addr-line>Department of Environmental & Occupational Health and of Social & Preventive Medicine</addr-line>,<institution>School of Public Health, Université de Montréal</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</aff><aff id="af75"><label>75</label><addr-line>Department of Medicine</addr-line>,<institution>McGill University</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</aff><aff id="af76"><label>76</label><addr-line>Division of Clinical Epidemiology</addr-line>,<institution>McGill University Health Centre, Royal Victoria Hospital</institution>,<addr-line>Montreal</addr-line>,<country>Canada</country>,</aff><aff id="af77"><label>77</label><addr-line>Cancer Genomics Laboratory</addr-line>,<institution>Centre Hospitalier Universitaire de Québec Research Center and Laval University</institution>,<addr-line>Quebec City</addr-line>,<country>Canada</country>,</aff><aff id="af78"><label>78</label><addr-line>Department of Epidemiology</addr-line>,<institution>University of California Irvine</institution>,<addr-line>Irvine</addr-line>,<country>USA</country>,</aff><aff id="af79"><label>79</label><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health</addr-line>,</aff><aff id="af80"><label>80</label><addr-line>Department of Pathology</addr-line>,</aff><aff id="af81"><label>81</label><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</aff><aff id="af82"><label>82</label><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center</addr-line>,<institution>Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville</addr-line>,<country>USA</country>,</aff><aff id="af83"><label>83</label><institution>Cogentech Cancer Genetic Test Laboratory</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</aff><aff id="af84"><label>84</label><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</aff><aff id="af85"><label>85</label><addr-line>Division of Cancer Prevention and Genetics</addr-line>,<institution>Istituto Europeo di Oncologia (IEO)</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</aff><aff id="af86"><label>86</label><addr-line>Department of Genetics and Pathology</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</aff><aff id="af87"><label>87</label><addr-line>Department of Surgical Oncology</addr-line>,</aff><aff id="af88"><label>88</label><addr-line>Department of Human Genetics & Department of Pathology</addr-line>,<institution>Leiden University Medical Center</institution>,<addr-line>Leiden</addr-line>,<country>The Netherlands</country>,</aff><aff id="af89"><label>89</label><addr-line>Family Cancer Clinic, Department of Medical Oncology</addr-line>,<institution>Erasmus MC-Daniel den Hoed Cancer Centrer</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</aff><aff id="af90"><label>90</label><institution>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)</institution>,<addr-line>Bochum</addr-line>,<country>Germany</country>,</aff><aff id="af91"><label>91</label><addr-line>Department of Internal Medicine</addr-line>,<institution>Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus</institution>,<addr-line>Bonn</addr-line>,<country>Germany</country>,</aff><aff id="af92"><label>92</label><institution>Institute of Pathology, Medical Faculty of the University of Bonn</institution>,<addr-line>Bonn</addr-line>,<country>Germany</country>,</aff><aff id="af93"><label>93</label><addr-line>Institute for Occupational Medicine and Maritime Medicine</addr-line>,<institution>University Medical Center Hamburg</institution>,<addr-line>Eppendorf</addr-line>,<country>Germany</country>,</aff><aff id="af94"><label>94</label><institution>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>,<addr-line>Stuttgart</addr-line>,<country>Germany</country>,</aff><aff id="af95"><label>95</label><institution>University of Tübingen</institution>,<addr-line>Tübingen</addr-line>,<country>Germany</country>,</aff><aff id="af96"><label>96</label><addr-line>Department of Pathology</addr-line>,<institution>Erasmus University Medical Center</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</aff><aff id="af97"><label>97</label><addr-line>Department of Medical Oncology</addr-line>,<institution>Erasmus MC Cancer Institute</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</aff><aff id="af98"><label>98</label><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville</addr-line>,<country>USA</country>,</aff><aff id="af99"><label>99</label><addr-line>Department of Cancer Epidemiology and Prevention</addr-line>,<institution>M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country>,</aff><aff id="af100"><label>100</label><addr-line>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</aff><aff id="af101"><label>101</label><addr-line>Clinical Science Institute</addr-line>,<institution>University Hospital Galway</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country>,</aff><aff id="af102"><label>102</label><addr-line>Department of Obstetrics and Gynecology</addr-line>,</aff><aff id="af103"><label>103</label><addr-line>National Center for Tumor Diseases</addr-line>,<institution>University of Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="af104"><label>104</label><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</aff><aff id="af105"><label>105</label><addr-line>Anatomical Pathology</addr-line>,<institution>The Alfred Hospital</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</aff><aff id="af106"><label>106</label><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</aff><aff id="af107"><label>107</label><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country>,</aff><aff id="af108"><label>108</label><addr-line>Netherlands Cancer Institute</addr-line>,<institution>Antoni van Leeuwenhoek Hospital</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</aff><aff id="af109"><label>109</label><addr-line>Center for Primary Health Care Research</addr-line>,<institution>University of Lund</institution>,<addr-line>Malmö</addr-line>,<country>Sweden</country>,</aff><aff id="af110"><label>110</label><addr-line>Institute of Human Genetics</addr-line>,<institution>Pontificia University Javeriana</institution>,<addr-line>Bogota</addr-line>,<country>Colombia</country>,</aff><aff id="af111"><label>111</label><addr-line>Institute of Pathology</addr-line>,<institution>Städtisches Klinikum Karlsruhe</institution>,<addr-line>Karlsruhe</addr-line>,<country>Germany</country>,</aff><aff id="af112"><label>112</label><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology</addr-line>,<institution>University Clinic Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</aff><aff id="af113"><label>113</label><institution>Universital Hospital Gasthuisberg</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</aff><aff id="af114"><label>114</label><addr-line>Laboratory for Translational Genetics, Department of Oncology</addr-line>,<institution>University of Leuven</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</aff><aff id="af115"><label>115</label><institution>Vesalius Research Center (VRC), VIB</institution>,<addr-line>Leuven</addr-line>,<country>Belgium</country>,</aff><aff id="af116"><label>116</label><institution>Beckman Research Institute of City of Hope</institution>,<addr-line>Duarte</addr-line>,<country>USA</country>,</aff><aff id="af117"><label>117</label><addr-line>Department of Radiation Oncology</addr-line>,</aff><aff id="af118"><label>118</label><addr-line>Department of Obstetrics and Gynaecology</addr-line>,<institution>Hannover Medical School</institution>,<addr-line>Hannover</addr-line>,<country>Germany</country>,</aff><aff id="af119"><label>119</label><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine</addr-line>,<institution>Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>Milan</addr-line>,<country>Italy</country> and</aff><aff id="af120"><label>120</label><addr-line>Division of Cancer Studies</addr-line>,<institution>Kings College London, Guy’s Hospital</institution>,<addr-line>London</addr-line>,<country>UK</country></aff></contrib-group><author-notes><corresp id="cor1"><label>*</label>To whom correspondence should be addressed at: Fergus J. Couch, Stabile 2-42, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Tel: +1 5072843623; Fax: +1 5075381937; Email: <email>couch.fergus@mayo.edu</email></corresp></author-notes><pub-date pub-type="ppub"><day>15</day><month>11</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>13</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>11</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>23</volume><issue>22</issue><fpage>6034</fpage><lpage>6046</lpage><history><date date-type="received"><day>19</day><month>11</month><year>2013</year></date><date date-type="rev-recd"><day>20</day><month>5</month><year>2014</year></date><date date-type="accepted"><day>10</day><month>6</month><year>2014</year></date></history><permissions><copyright-statement>Published by Oxford University Press 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.</copyright-statement><copyright-year>2014</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="ddu300.pdf"></self-uri><abstract><p>Mitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. Several small candidate gene studies have reported associations between variation in mitotic genes and breast cancer risk. We measured associations between 2156 single nucleotide polymorphisms (SNPs) from 194 mitotic genes and breast cancer risk, overall and by histologic grade, in the Breast Cancer Association Consortium (BCAC) iCOGS study (<italic>n</italic> = 39 067 cases; <italic>n</italic> = 42 106 controls). SNPs in <italic>TACC2</italic> [rs17550038: odds ratio (OR) = 1.24, 95% confidence interval (CI) 1.16–1.33, <italic>P</italic> = 4.2 × 10<sup>−10</sup>) and <italic>EIF3H</italic> (rs799890: OR = 1.07, 95% CI 1.04–1.11, <italic>P</italic> = 8.7 × 10<sup>−6</sup>) were significantly associated with risk of low-grade breast cancer. The <italic>TACC2</italic> signal was retained (rs17550038: OR = 1.15, 95% CI 1.07–1.23, <italic>P</italic> = 7.9 × 10<sup>−5</sup>) after adjustment for breast cancer risk SNPs in the nearby <italic>FGFR2</italic> gene, suggesting that <italic>TACC2</italic> is a novel, independent genome-wide significant genetic risk locus for low-grade breast cancer. While no SNPs were individually associated with high-grade disease, a pathway-level gene set analysis showed that variation across the 194 mitotic genes was associated with high-grade breast cancer risk (<italic>P</italic> = 2.1 × 10<sup>−3</sup>). These observations will provide insight into the contribution of mitotic defects to histological grade and the etiology of breast cancer.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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