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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease</title><author><name sortKey="Amin Al Olama, Ali" sort="Amin Al Olama, Ali" uniqKey="Amin Al Olama A" first="Ali" last="Amin Al Olama">Ali Amin Al Olama</name><affiliation><nlm:aff id="af1"><addr-line>Strangeways Laboratory</addr-line>,<institution>Centre for Cancer Genetic Epidemiology</institution>,<addr-line>Worts Causeway, Cambridge CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation><nlm:aff id="af3"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Centre</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation><nlm:aff id="af4"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institute</institution>,<addr-line>Stockholm SE-171 77</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation><nlm:aff id="af5"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute, NIH</institution>,<addr-line>Bethesda, MD 20892</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af6"><addr-line>Core Genotyping Facility</addr-line>,<institution>SAIC-Frederick, Inc., National Cancer Institute, NIH</institution>,<addr-line>Gaithersburg, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Benlloch, Sara" sort="Benlloch, Sara" uniqKey="Benlloch S" first="Sara" last="Benlloch">Sara Benlloch</name><affiliation><nlm:aff id="af1"><addr-line>Strangeways Laboratory</addr-line>,<institution>Centre for Cancer Genetic Epidemiology</institution>,<addr-line>Worts Causeway, Cambridge CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="af7"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>1 Rathdowne Street, Carlton, VIC 3053</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af8"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>723 Swanston Street, Carlton, VIC 3053</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="af7"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>1 Rathdowne Street, Carlton, VIC 3053</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af8"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>723 Swanston Street, Carlton, VIC 3053</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><affiliation><nlm:aff id="af9"><addr-line>Surgical Oncology (Uro-Oncology: S4)</addr-line>,<institution>Addenbrooke's Hospital, University of Cambridge</institution>,<addr-line>Box 279, Hills Road, Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af10"><institution>Li Ka Shing Centre, Cancer Research UK Cambridge Research Institute</institution>,<addr-line>Cambridge CB2 2QQ</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C." last="Hamdy">Freddie C. Hamdy</name><affiliation><nlm:aff wicri:cut=" and" id="af11"><addr-line>Nuffield Department of Surgery</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af13"><addr-line>Faculty of Medical Science</addr-line>,<institution>University of Oxford, John Radcliffe Hospital</institution>,<addr-line>Oxford OX3 9DU</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L." last="Donovan">Jenny L. Donovan</name><affiliation><nlm:aff id="af14"><addr-line>School of Social and Community Medicine</addr-line>,<institution>University of Bristol</institution>,<addr-line>Canynge Hall, 39 Whatley Road, Bristol BS8 2PS</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Program in Molecular and Genetic Epidemiology, Department of Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="af3"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Centre</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Thun, Michael J" sort="Thun, Michael J" uniqKey="Thun M" first="Michael J." last="Thun">Michael J. Thun</name><affiliation><nlm:aff id="af17"><addr-line>Epidemiology Research Program</addr-line>,<institution>American Cancer Society</institution>,<addr-line>Atlanta, GA 30303</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Gaziano, Michael" sort="Gaziano, Michael" uniqKey="Gaziano M" first="Michael" last="Gaziano">Michael Gaziano</name><affiliation><nlm:aff id="af18"><institution>Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) and Geriatric Research, Education, and Clinical Center (GRECC), Boston Veterans Affairs Healthcare System</institution>,<addr-line>Boston, MA 02114</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af19"><addr-line>Division of Aging, Department of Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA 02215</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name><affiliation><nlm:aff id="af16"><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Siddiq, Afshan" sort="Siddiq, Afshan" uniqKey="Siddiq A" first="Afshan" last="Siddiq">Afshan Siddiq</name><affiliation><nlm:aff id="af20"><addr-line>Department of Genomics of Common Disease</addr-line>,<institution>School of Public Health, Imperial College</institution>,<addr-line>London SW7 2AZ</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="af12"><addr-line>Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Cox, David G" sort="Cox, David G" uniqKey="Cox D" first="David G." last="Cox">David G. Cox</name><affiliation><nlm:aff id="af21"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>School of Public Health, Imperial College London</institution>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af22"><addr-line>Lyon Cancer Research Center</addr-line>,<institution>INSERM U1052</institution>,<addr-line>Lyon</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation><nlm:aff id="af23"><addr-line>Genomic Epidemiology Group</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:aff id="af21"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>School of Public Health, Imperial College London</institution>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J." last="Key">Timothy J. Key</name><affiliation><nlm:aff id="af12"><addr-line>Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Andriole, Gerald" sort="Andriole, Gerald" uniqKey="Andriole G" first="Gerald" last="Andriole">Gerald Andriole</name><affiliation><nlm:aff id="af26"><addr-line>Division of Urologic Surgery</addr-line>,<institution>Washington University School of Medicine</institution>,<addr-line>St Louis, MO</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation><nlm:aff id="af5"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute, NIH</institution>,<addr-line>Bethesda, MD 20892</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B." last="Hayes">Richard B. Hayes</name><affiliation><nlm:aff id="af27"><addr-line>Division of Epidemiology, Department of Environmental Medicine</addr-line>,<institution>NYU Langone Medical Centre, NYU Cancer Institute</institution>,<addr-line>New York, NY 10016</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Schleutker, Johanna" sort="Schleutker, Johanna" uniqKey="Schleutker J" first="Johanna" last="Schleutker">Johanna Schleutker</name><affiliation><nlm:aff wicri:cut=" and" id="af28"><institution>Institute of Biomedical Technology/BioMediTech, University of Tampere</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af32"><addr-line>Department of Medical Biochemistry and Genetics</addr-line>,<institution>University of Turku</institution>,<addr-line>Turku</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Auvinen, Anssi" sort="Auvinen, Anssi" uniqKey="Auvinen A" first="Anssi" last="Auvinen">Anssi Auvinen</name><affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Department of Epidemiology</addr-line>,<institution>School of Health Sciences</institution></nlm:aff></affiliation></author><author><name sortKey="Tammela, Teuvo L J" sort="Tammela, Teuvo L J" uniqKey="Tammela T" first="Teuvo L. J." last="Tammela">Teuvo L. J. Tammela</name><affiliation><nlm:aff id="af31"><addr-line>Department of Urology</addr-line>,<institution>Tampere University Hospital and Medical School, University of Tampere</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Weischer, Maren" sort="Weischer, Maren" uniqKey="Weischer M" first="Maren" last="Weischer">Maren Weischer</name><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Clinical Biochemistry</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stanford, Janet L" sort="Stanford, Janet L" uniqKey="Stanford J" first="Janet L." last="Stanford">Janet L. Stanford</name><affiliation><nlm:aff id="af35"><addr-line>Division of Public Health Sciences</addr-line>,<institution>Fred Hutchinson Cancer Research Centre</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af36"><addr-line>Department of Epidemiology</addr-line>,<institution>School of Public Health, University of Washington</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ostrander, Elaine A" sort="Ostrander, Elaine A" uniqKey="Ostrander E" first="Elaine A." last="Ostrander">Elaine A. Ostrander</name><affiliation><nlm:aff id="af37"><institution>National Human Genome Research Institute, National Institutes of Health</institution>,<addr-line>50 South Drive, Room 5351, Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name><affiliation><nlm:aff id="af38"><addr-line>Department of Genetics and Pathology, International Hereditary Cancer Center</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="af38"><addr-line>Department of Genetics and Pathology, International Hereditary Cancer Center</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Thibodeau, Stephen N" sort="Thibodeau, Stephen N" uniqKey="Thibodeau S" first="Stephen N." last="Thibodeau">Stephen N. Thibodeau</name><affiliation><nlm:aff id="af39"><institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Schaid, Daniel J" sort="Schaid, Daniel J" uniqKey="Schaid D" first="Daniel J." last="Schaid">Daniel J. Schaid</name><affiliation><nlm:aff id="af39"><institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Sorensen, Karina D" sort="Sorensen, Karina D" uniqKey="Sorensen K" first="Karina D." last="Sorensen">Karina D. Sorensen</name><affiliation><nlm:aff wicri:cut=" and" id="af40"><addr-line>Department of Molecular Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Batra, Jyotsna" sort="Batra, Jyotsna" uniqKey="Batra J" first="Jyotsna" last="Batra">Jyotsna Batra</name><affiliation><nlm:aff id="af42"><institution>Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation, Queensland University of Technology</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Clements, Judith A" sort="Clements, Judith A" uniqKey="Clements J" first="Judith A." last="Clements">Judith A. Clements</name><affiliation><nlm:aff id="af42"><institution>Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation, Queensland University of Technology</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Chambers, Suzanne" sort="Chambers, Suzanne" uniqKey="Chambers S" first="Suzanne" last="Chambers">Suzanne Chambers</name><affiliation><nlm:aff id="af43"><institution>Griffith Health Institute, Griffith University</institution>,<addr-line>Gold Coast, QLD</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af44"><institution>Viertel Centre for Research in Cancer Control, Cancer Council Queensland</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af45"><institution>Centre for Clinical Research, University of Queensland</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Aitken, Joanne" sort="Aitken, Joanne" uniqKey="Aitken J" first="Joanne" last="Aitken">Joanne Aitken</name><affiliation><nlm:aff id="af44"><institution>Viertel Centre for Research in Cancer Control, Cancer Council Queensland</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Gardiner, Robert A" sort="Gardiner, Robert A" uniqKey="Gardiner R" first="Robert A." last="Gardiner">Robert A. Gardiner</name><affiliation><nlm:aff id="af45"><institution>Centre for Clinical Research, University of Queensland</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Maier, Christiane" sort="Maier, Christiane" uniqKey="Maier C" first="Christiane" last="Maier">Christiane Maier</name><affiliation><nlm:aff wicri:cut=" and" id="af46"><addr-line>Department of Urology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af47"><institution>Institute of Human Genetics, University Hospital Ulm</institution>,<addr-line>Ulm</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Vogel, Walther" sort="Vogel, Walther" uniqKey="Vogel W" first="Walther" last="Vogel">Walther Vogel</name><affiliation><nlm:aff id="af47"><institution>Institute of Human Genetics, University Hospital Ulm</institution>,<addr-line>Ulm</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="af48"><institution>Hannover Medical School</institution>,<addr-line>Hannover</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff wicri:cut=" and" id="af24"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation></author><author><name sortKey="Habuchi, Tomonori" sort="Habuchi, Tomonori" uniqKey="Habuchi T" first="Tomonori" last="Habuchi">Tomonori Habuchi</name><affiliation><nlm:aff id="af49"><addr-line>Department of Urology,</addr-line><institution>Akita University Graduate School of Medicine</institution>,<addr-line>1-1-1 Hondo, Akita 010-8543</addr-line>,<country>Japan</country>,</nlm:aff></affiliation></author><author><name sortKey="Ingles, Sue" sort="Ingles, Sue" uniqKey="Ingles S" first="Sue" last="Ingles">Sue Ingles</name><affiliation><nlm:aff id="af3"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Centre</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="af50"><institution>Cancer Prevention Institute of California</institution>,<addr-line>Fremont</addr-line>, CA,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af51"><institution>Division of Epidemiology, Department of Health Research and Policy and Stanford Cancer Institute, Stanford University School of Medicine</institution>,<addr-line>Stanford, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Dickinson, Joanne L" sort="Dickinson, Joanne L" uniqKey="Dickinson J" first="Joanne L." last="Dickinson">Joanne L. Dickinson</name><affiliation><nlm:aff id="af52"><institution>Menzies Research Institute Tasmania, University of Tasmania</institution>,<addr-line>Hobart, TAS</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Cannon Albright, Lisa" sort="Cannon Albright, Lisa" uniqKey="Cannon Albright L" first="Lisa" last="Cannon-Albright">Lisa Cannon-Albright</name><affiliation><nlm:aff id="af53"><addr-line>Division of Genetic Epidemiology, Department of Internal Medicine</addr-line>,<institution>University of Utah School of Medicine</institution>,<addr-line>Salt Lake City, UT</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af54"><addr-line>George E. Wahlen Department of Veterans Affairs Medical Centre, Salt Lake City, UT</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R." last="Teixeira">Manuel R. Teixeira</name><affiliation><nlm:aff id="af55"><addr-line>Department of Genetics</addr-line>,<institution>Portuguese Oncology Institute and Biomedical Sciences Institute (ICBAS), Porto University</institution>,<addr-line>Porto</addr-line>,<country>Portugal</country>,</nlm:aff></affiliation></author><author><name sortKey="Kaneva, Radka" sort="Kaneva, Radka" uniqKey="Kaneva R" first="Radka" last="Kaneva">Radka Kaneva</name><affiliation><nlm:aff id="af56"><addr-line>Molecular Medicine Centre, Department of Medical Chemistry and Biochemistry</addr-line>,<institution>Medical University of Sofia</institution>,<addr-line>2 Zdrave St, Sofia 1431</addr-line>,<country>Bulgaria</country>,</nlm:aff></affiliation></author><author><name sortKey="Zhang, Hong Wei" sort="Zhang, Hong Wei" uniqKey="Zhang H" first="Hong-Wei" last="Zhang">Hong-Wei Zhang</name><affiliation><nlm:aff id="af57"><addr-line>Department of Epidemiology</addr-line>,<institution>Second Military Medical University</institution>,<addr-line>Shanghai</addr-line>,<country>China</country>,</nlm:aff></affiliation></author><author><name sortKey="Lu, Yong Jie" sort="Lu, Yong Jie" uniqKey="Lu Y" first="Yong-Jie" last="Lu">Yong-Jie Lu</name><affiliation><nlm:aff id="af58"><institution>Centre for Molecular Oncology and Imaging, Barts Cancer Institute, Queen Mary University of London</institution>,<addr-line>Charterhouse Square, London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Park, Jong Y" sort="Park, Jong Y" uniqKey="Park J" first="Jong Y." last="Park">Jong Y. Park</name><affiliation><nlm:aff id="af59"><addr-line>Division of Cancer Prevention and Control</addr-line>,<institution>H. Lee Moffitt Cancer Centre</institution>,<addr-line>12902 Magnolia Drive, Tampa, FL</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Cooney, Kathleen A" sort="Cooney, Kathleen A" uniqKey="Cooney K" first="Kathleen A." last="Cooney">Kathleen A. Cooney</name><affiliation><nlm:aff wicri:cut=" and" id="af60"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af61"><addr-line>Department of Urology</addr-line>,<institution>University of Michigan Medical School</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth R" sort="Muir, Kenneth R" uniqKey="Muir K" first="Kenneth R." last="Muir">Kenneth R. Muir</name><affiliation><nlm:aff id="af62"><institution>Warwick Medical School, University of Warwick</institution>,<addr-line>Coventry</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Leongamornlert, Daniel A" sort="Leongamornlert, Daniel A" uniqKey="Leongamornlert D" first="Daniel A." last="Leongamornlert">Daniel A. Leongamornlert</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Saunders, Edward" sort="Saunders, Edward" uniqKey="Saunders E" first="Edward" last="Saunders">Edward Saunders</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Tymrakiewicz, Malgorzata" sort="Tymrakiewicz, Malgorzata" uniqKey="Tymrakiewicz M" first="Malgorzata" last="Tymrakiewicz">Malgorzata Tymrakiewicz</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Mahmud, Nadiya" sort="Mahmud, Nadiya" uniqKey="Mahmud N" first="Nadiya" last="Mahmud">Nadiya Mahmud</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Guy, Michelle" sort="Guy, Michelle" uniqKey="Guy M" first="Michelle" last="Guy">Michelle Guy</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Govindasami, Koveela" sort="Govindasami, Koveela" uniqKey="Govindasami K" first="Koveela" last="Govindasami">Koveela Govindasami</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="O Brien, Lynne T" sort="O Brien, Lynne T" uniqKey="O Brien L" first="Lynne T." last="O'Brien">Lynne T. O'Brien</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Wilkinson, Rosemary A" sort="Wilkinson, Rosemary A" uniqKey="Wilkinson R" first="Rosemary A." last="Wilkinson">Rosemary A. Wilkinson</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hall, Amanda L" sort="Hall, Amanda L" uniqKey="Hall A" first="Amanda L." last="Hall">Amanda L. Hall</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Emma J" sort="Sawyer, Emma J" uniqKey="Sawyer E" first="Emma J." last="Sawyer">Emma J. Sawyer</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Dadaev, Tokhir" sort="Dadaev, Tokhir" uniqKey="Dadaev T" first="Tokhir" last="Dadaev">Tokhir Dadaev</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Morrison, Jonathan" sort="Morrison, Jonathan" uniqKey="Morrison J" first="Jonathan" last="Morrison">Jonathan Morrison</name><affiliation><nlm:aff id="af1"><addr-line>Strangeways Laboratory</addr-line>,<institution>Centre for Cancer Genetic Epidemiology</institution>,<addr-line>Worts Causeway, Cambridge CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Dearnaley, David P" sort="Dearnaley, David P" uniqKey="Dearnaley D" first="David P." last="Dearnaley">David P. Dearnaley</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Horwich, Alan" sort="Horwich, Alan" uniqKey="Horwich A" first="Alan" last="Horwich">Alan Horwich</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Huddart, Robert A" sort="Huddart, Robert A" uniqKey="Huddart R" first="Robert A." last="Huddart">Robert A. Huddart</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Khoo, Vincent S" sort="Khoo, Vincent S" uniqKey="Khoo V" first="Vincent S." last="Khoo">Vincent S. Khoo</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Parker, Christopher C" sort="Parker, Christopher C" uniqKey="Parker C" first="Christopher C." last="Parker">Christopher C. Parker</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Van As, Nicholas" sort="Van As, Nicholas" uniqKey="Van As N" first="Nicholas" last="Van As">Nicholas Van As</name><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Woodhouse, Christopher J" sort="Woodhouse, Christopher J" uniqKey="Woodhouse C" first="Christopher J." last="Woodhouse">Christopher J. Woodhouse</name><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Thompson, Alan" sort="Thompson, Alan" uniqKey="Thompson A" first="Alan" last="Thompson">Alan Thompson</name><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Dudderidge, Tim" sort="Dudderidge, Tim" uniqKey="Dudderidge T" first="Tim" last="Dudderidge">Tim Dudderidge</name><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Ogden, Chris" sort="Ogden, Chris" uniqKey="Ogden C" first="Chris" last="Ogden">Chris Ogden</name><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Cooper, Colin S" sort="Cooper, Colin S" uniqKey="Cooper C" first="Colin S." last="Cooper">Colin S. Cooper</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Lophatonanon, Artitaya" sort="Lophatonanon, Artitaya" uniqKey="Lophatonanon A" first="Artitaya" last="Lophatonanon">Artitaya Lophatonanon</name><affiliation><nlm:aff id="af62"><institution>Warwick Medical School, University of Warwick</institution>,<addr-line>Coventry</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="af64"><addr-line>Genetic Epidemiology Laboratory, Department of Pathology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Grattan street, Parkville, VIC</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="af65"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>1 Rathdowne Street, Carlton, VIC</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="English, Dallas" sort="English, Dallas" uniqKey="English D" first="Dallas" last="English">Dallas English</name><affiliation><nlm:aff id="af65"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>1 Rathdowne Street, Carlton, VIC</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af66"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>723 Swanston Street, Carlton, VIC</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation><nlm:aff id="af67"><addr-line>Department of Chronic Disease Prevention</addr-line>,<institution>National Institute for Health and Welfare</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="af68"><addr-line>Epidemiology Program, University of Hawaii Cancer Centre, Department of Medicine, John A. Burns School of Medicine</addr-line>,<institution>University of Hawaii</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Campa, Daniele" sort="Campa, Daniele" uniqKey="Campa D" first="Daniele" last="Campa">Daniele Campa</name><affiliation><nlm:aff id="af22"><addr-line>Lyon Cancer Research Center</addr-line>,<institution>INSERM U1052</institution>,<addr-line>Lyon</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:aff id="af25"><addr-line>Division of Cancer Epidemiology</addr-line>,<institution>German Cancer Research Centre (DKFZ)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Program in Molecular and Genetic Epidemiology, Department of Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name><affiliation><nlm:aff id="af17"><addr-line>Epidemiology Research Program</addr-line>,<institution>American Cancer Society</institution>,<addr-line>Atlanta, GA 30303</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Gapstur, Susan" sort="Gapstur, Susan" uniqKey="Gapstur S" first="Susan" last="Gapstur">Susan Gapstur</name><affiliation><nlm:aff id="af17"><addr-line>Epidemiology Research Program</addr-line>,<institution>American Cancer Society</institution>,<addr-line>Atlanta, GA 30303</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Yeager, Meredith" sort="Yeager, Meredith" uniqKey="Yeager M" first="Meredith" last="Yeager">Meredith Yeager</name><affiliation><nlm:aff id="af5"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute, NIH</institution>,<addr-line>Bethesda, MD 20892</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af6"><addr-line>Core Genotyping Facility</addr-line>,<institution>SAIC-Frederick, Inc., National Cancer Institute, NIH</institution>,<addr-line>Gaithersburg, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="af69"><addr-line>Department of Oncology</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Stern, Mariana C" sort="Stern, Mariana C" uniqKey="Stern M" first="Mariana C." last="Stern">Mariana C. Stern</name><affiliation><nlm:aff id="af3"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Centre</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Corral, Roman" sort="Corral, Roman" uniqKey="Corral R" first="Roman" last="Corral">Roman Corral</name><affiliation><nlm:aff id="af3"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Centre</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Aly, Markus" sort="Aly, Markus" uniqKey="Aly M" first="Markus" last="Aly">Markus Aly</name><affiliation><nlm:aff id="af4"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institute</institution>,<addr-line>Stockholm SE-171 77</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af70"><addr-line>Division of Urology, Department of Clinical Sciences</addr-line>,<institution>Danderyd Hospital</institution></nlm:aff></affiliation></author><author><name sortKey="Isaacs, William" sort="Isaacs, William" uniqKey="Isaacs W" first="William" last="Isaacs">William Isaacs</name><affiliation><nlm:aff id="af72"><addr-line>School of Medicine</addr-line>,<institution>Johns Hopkins University</institution>,<addr-line>115 Marburg Building, 600 North Wolfe Street, Baltimore, MD 21205</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Adolfsson, Jan" sort="Adolfsson, Jan" uniqKey="Adolfsson J" first="Jan" last="Adolfsson">Jan Adolfsson</name><affiliation><nlm:aff id="af71"><institution>Oncological Centre, CLINTEC, Karolinska Institute</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Xu, Jianfeng" sort="Xu, Jianfeng" uniqKey="Xu J" first="Jianfeng" last="Xu">Jianfeng Xu</name><affiliation><nlm:aff id="af73"><institution>Center for Cancer Genomics, Wake Forest University School of Medicine, Medical Center Boulevard</institution>,<addr-line>Winston-Salem, NC 27157</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Zheng, S Lilly" sort="Zheng, S Lilly" uniqKey="Zheng S" first="S. Lilly" last="Zheng">S. Lilly Zheng</name><affiliation><nlm:aff id="af73"><institution>Center for Cancer Genomics, Wake Forest University School of Medicine, Medical Center Boulevard</institution>,<addr-line>Winston-Salem, NC 27157</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wahlfors, Tiina" sort="Wahlfors, Tiina" uniqKey="Wahlfors T" first="Tiina" last="Wahlfors">Tiina Wahlfors</name><affiliation><nlm:aff id="af31"><addr-line>Department of Urology</addr-line>,<institution>Tampere University Hospital and Medical School, University of Tampere</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Taari, Kimmo" sort="Taari, Kimmo" uniqKey="Taari K" first="Kimmo" last="Taari">Kimmo Taari</name><affiliation><nlm:aff id="af74"><addr-line>Department of Urology</addr-line>,<institution>Helsinki University Central Hospital, University of Helsinki</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Kujala, Paula" sort="Kujala, Paula" uniqKey="Kujala P" first="Paula" last="Kujala">Paula Kujala</name><affiliation><nlm:aff id="af29"><addr-line>Department of Pathology, Centre for Laboratory Medicine</addr-line>,<institution>Tampere University Hospital</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Klarskov, Peter" sort="Klarskov, Peter" uniqKey="Klarskov P" first="Peter" last="Klarskov">Peter Klarskov</name><affiliation><nlm:aff id="af34"><addr-line>Department of Urology</addr-line>,<institution>Herlev Hospital, Copenhagen University Hospital</institution>,<addr-line>Herlev Ringvej 75, Herlev DK-2730</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Clinical Biochemistry</addr-line></nlm:aff></affiliation></author><author><name sortKey="R Der, M Andreas" sort="R Der, M Andreas" uniqKey="R Der M" first="M. Andreas" last="R Der">M. Andreas R Der</name><affiliation><nlm:aff wicri:cut=" and" id="af75"><addr-line>Department of Urology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Frikke Schmidt, Ruth" sort="Frikke Schmidt, Ruth" uniqKey="Frikke Schmidt R" first="Ruth" last="Frikke-Schmidt">Ruth Frikke-Schmidt</name><affiliation><nlm:aff id="af76"><addr-line>Department of Clinical Biochemistry</addr-line>,<institution>Rigshospitalet, Copenhagen University Hospital</institution>,<addr-line>Blegdamsvej 9, Copenhagen DK-2100</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Clinical Biochemistry</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M." last="Fitzgerald">Liesel M. Fitzgerald</name><affiliation><nlm:aff id="af35"><addr-line>Division of Public Health Sciences</addr-line>,<institution>Fred Hutchinson Cancer Research Centre</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Kolb, Suzanne" sort="Kolb, Suzanne" uniqKey="Kolb S" first="Suzanne" last="Kolb">Suzanne Kolb</name><affiliation><nlm:aff id="af35"><addr-line>Division of Public Health Sciences</addr-line>,<institution>Fred Hutchinson Cancer Research Centre</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Kwon, Erika M" sort="Kwon, Erika M" uniqKey="Kwon E" first="Erika M." last="Kwon">Erika M. Kwon</name><affiliation><nlm:aff id="af37"><institution>National Human Genome Research Institute, National Institutes of Health</institution>,<addr-line>50 South Drive, Room 5351, Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Karyadi, Danielle M" sort="Karyadi, Danielle M" uniqKey="Karyadi D" first="Danielle M." last="Karyadi">Danielle M. Karyadi</name><affiliation><nlm:aff id="af37"><institution>National Human Genome Research Institute, National Institutes of Health</institution>,<addr-line>50 South Drive, Room 5351, Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Orntoft, Torben Falck" sort="Orntoft, Torben Falck" uniqKey="Orntoft T" first="Torben Falck" last="Orntoft">Torben Falck Orntoft</name><affiliation><nlm:aff wicri:cut=" and" id="af40"><addr-line>Department of Molecular Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Borre, Michael" sort="Borre, Michael" uniqKey="Borre M" first="Michael" last="Borre">Michael Borre</name><affiliation><nlm:aff id="af41"><addr-line>Department of Urology</addr-line>,<institution>Aarhus University Hospital</institution>,<addr-line>Skejby</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Rinckleb, Antje" sort="Rinckleb, Antje" uniqKey="Rinckleb A" first="Antje" last="Rinckleb">Antje Rinckleb</name><affiliation><nlm:aff wicri:cut=" and" id="af46"><addr-line>Department of Urology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Luedeke, Manuel" sort="Luedeke, Manuel" uniqKey="Luedeke M" first="Manuel" last="Luedeke">Manuel Luedeke</name><affiliation><nlm:aff id="af47"><institution>Institute of Human Genetics, University Hospital Ulm</institution>,<addr-line>Ulm</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Herkommer, Kathleen" sort="Herkommer, Kathleen" uniqKey="Herkommer K" first="Kathleen" last="Herkommer">Kathleen Herkommer</name><affiliation><nlm:aff id="af77"><addr-line>Department of Urology</addr-line>,<institution>Rechts der Isar Medical Centre, Technical University of Munich</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Meyer, Andreas" sort="Meyer, Andreas" uniqKey="Meyer A" first="Andreas" last="Meyer">Andreas Meyer</name><affiliation><nlm:aff id="af48"><institution>Hannover Medical School</institution>,<addr-line>Hannover</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Serth, Jurgen" sort="Serth, Jurgen" uniqKey="Serth J" first="Jürgen" last="Serth">Jürgen Serth</name><affiliation><nlm:aff id="af48"><institution>Hannover Medical School</institution>,<addr-line>Hannover</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Marthick, James R" sort="Marthick, James R" uniqKey="Marthick J" first="James R." last="Marthick">James R. Marthick</name><affiliation><nlm:aff id="af52"><institution>Menzies Research Institute Tasmania, University of Tasmania</institution>,<addr-line>Hobart, TAS</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Patterson, Briony" sort="Patterson, Briony" uniqKey="Patterson B" first="Briony" last="Patterson">Briony Patterson</name><affiliation><nlm:aff id="af52"><institution>Menzies Research Institute Tasmania, University of Tasmania</institution>,<addr-line>Hobart, TAS</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Wokolorczyk, Dominika" sort="Wokolorczyk, Dominika" uniqKey="Wokolorczyk D" first="Dominika" last="Wokolorczyk">Dominika Wokolorczyk</name><affiliation><nlm:aff id="af38"><addr-line>Department of Genetics and Pathology, International Hereditary Cancer Center</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda" sort="Spurdle, Amanda" uniqKey="Spurdle A" first="Amanda" last="Spurdle">Amanda Spurdle</name><affiliation><nlm:aff wicri:cut=" and" id="af79"><institution>Huntsman Cancer Institute</institution>,<addr-line>Salt Lake City, UT</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lose, Felicity" sort="Lose, Felicity" uniqKey="Lose F" first="Felicity" last="Lose">Felicity Lose</name><affiliation><nlm:aff id="af78"><addr-line>Molecular Cancer Epidemiology Laboratory</addr-line>,<institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Mcdonnell, Shannon K" sort="Mcdonnell, Shannon K" uniqKey="Mcdonnell S" first="Shannon K." last="Mcdonnell">Shannon K. Mcdonnell</name><affiliation><nlm:aff id="af39"><institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Joshi, Amit D" sort="Joshi, Amit D" uniqKey="Joshi A" first="Amit D." last="Joshi">Amit D. Joshi</name><affiliation><nlm:aff id="af3"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Centre</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Shahabi, Ahva" sort="Shahabi, Ahva" uniqKey="Shahabi A" first="Ahva" last="Shahabi">Ahva Shahabi</name><affiliation><nlm:aff id="af3"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Centre</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Pinto, Pedro" sort="Pinto, Pedro" uniqKey="Pinto P" first="Pedro" last="Pinto">Pedro Pinto</name><affiliation><nlm:aff id="af55"><addr-line>Department of Genetics</addr-line>,<institution>Portuguese Oncology Institute and Biomedical Sciences Institute (ICBAS), Porto University</institution>,<addr-line>Porto</addr-line>,<country>Portugal</country>,</nlm:aff></affiliation></author><author><name sortKey="Santos, Joana" sort="Santos, Joana" uniqKey="Santos J" first="Joana" last="Santos">Joana Santos</name><affiliation><nlm:aff id="af55"><addr-line>Department of Genetics</addr-line>,<institution>Portuguese Oncology Institute and Biomedical Sciences Institute (ICBAS), Porto University</institution>,<addr-line>Porto</addr-line>,<country>Portugal</country>,</nlm:aff></affiliation></author><author><name sortKey="Ray, Ana" sort="Ray, Ana" uniqKey="Ray A" first="Ana" last="Ray">Ana Ray</name><affiliation><nlm:aff wicri:cut=" and" id="af60"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af61"><addr-line>Department of Urology</addr-line>,<institution>University of Michigan Medical School</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name><affiliation><nlm:aff id="af59"><addr-line>Division of Cancer Prevention and Control</addr-line>,<institution>H. Lee Moffitt Cancer Centre</institution>,<addr-line>12902 Magnolia Drive, Tampa, FL</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lin, Hui Yi" sort="Lin, Hui Yi" uniqKey="Lin H" first="Hui-Yi" last="Lin">Hui-Yi Lin</name><affiliation><nlm:aff id="af59"><addr-line>Division of Cancer Prevention and Control</addr-line>,<institution>H. Lee Moffitt Cancer Centre</institution>,<addr-line>12902 Magnolia Drive, Tampa, FL</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Stephenson, Robert A" sort="Stephenson, Robert A" uniqKey="Stephenson R" first="Robert A." last="Stephenson">Robert A. Stephenson</name><affiliation><nlm:aff wicri:cut=" and" id="af79"><institution>Huntsman Cancer Institute</institution>,<addr-line>Salt Lake City, UT</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Teerlink, Craig" sort="Teerlink, Craig" uniqKey="Teerlink C" first="Craig" last="Teerlink">Craig Teerlink</name><affiliation><nlm:aff id="af53"><addr-line>Division of Genetic Epidemiology, Department of Internal Medicine</addr-line>,<institution>University of Utah School of Medicine</institution>,<addr-line>Salt Lake City, UT</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Muller">Heiko Muller</name><affiliation><nlm:aff wicri:cut=" and" id="af24"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rothenbacher, Dietrich" sort="Rothenbacher, Dietrich" uniqKey="Rothenbacher D" first="Dietrich" last="Rothenbacher">Dietrich Rothenbacher</name><affiliation><nlm:aff wicri:cut=" and" id="af24"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tsuchiya, Norihiko" sort="Tsuchiya, Norihiko" uniqKey="Tsuchiya N" first="Norihiko" last="Tsuchiya">Norihiko Tsuchiya</name><affiliation><nlm:aff id="af49"><addr-line>Department of Urology,</addr-line><institution>Akita University Graduate School of Medicine</institution>,<addr-line>1-1-1 Hondo, Akita 010-8543</addr-line>,<country>Japan</country>,</nlm:aff></affiliation></author><author><name sortKey="Narita, Shintaro" sort="Narita, Shintaro" uniqKey="Narita S" first="Shintaro" last="Narita">Shintaro Narita</name><affiliation><nlm:aff id="af49"><addr-line>Department of Urology,</addr-line><institution>Akita University Graduate School of Medicine</institution>,<addr-line>1-1-1 Hondo, Akita 010-8543</addr-line>,<country>Japan</country>,</nlm:aff></affiliation></author><author><name sortKey="Cao, Guang Wen" sort="Cao, Guang Wen" uniqKey="Cao G" first="Guang-Wen" last="Cao">Guang-Wen Cao</name><affiliation><nlm:aff id="af57"><addr-line>Department of Epidemiology</addr-line>,<institution>Second Military Medical University</institution>,<addr-line>Shanghai</addr-line>,<country>China</country>,</nlm:aff></affiliation></author><author><name sortKey="Slavov, Chavdar" sort="Slavov, Chavdar" uniqKey="Slavov C" first="Chavdar" last="Slavov">Chavdar Slavov</name><affiliation><nlm:aff id="af80"><addr-line>Department of Urology and Alexandrovska University Hospital,</addr-line><institution>Medical University of Sofia</institution>,<addr-line>Sofia</addr-line>,<country>Bulgaria</country></nlm:aff></affiliation></author><author><name sortKey="Mitev, Vanio" sort="Mitev, Vanio" uniqKey="Mitev V" first="Vanio" last="Mitev">Vanio Mitev</name><affiliation><nlm:aff id="af56"><addr-line>Molecular Medicine Centre, Department of Medical Chemistry and Biochemistry</addr-line>,<institution>Medical University of Sofia</institution>,<addr-line>2 Zdrave St, Sofia 1431</addr-line>,<country>Bulgaria</country>,</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen" sort="Chanock, Stephen" uniqKey="Chanock S" first="Stephen" last="Chanock">Stephen Chanock</name><affiliation><nlm:aff id="af6"><addr-line>Core Genotyping Facility</addr-line>,<institution>SAIC-Frederick, Inc., National Cancer Institute, NIH</institution>,<addr-line>Gaithersburg, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Gronberg">Henrik Gronberg</name><affiliation><nlm:aff id="af4"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institute</institution>,<addr-line>Stockholm SE-171 77</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="af3"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Centre</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Program in Molecular and Genetic Epidemiology, Department of Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="af1"><addr-line>Strangeways Laboratory</addr-line>,<institution>Centre for Cancer Genetic Epidemiology</institution>,<addr-line>Worts Causeway, Cambridge CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23065704</idno><idno type="pmc">3526158</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526158</idno><idno type="RBID">PMC:3526158</idno><idno type="doi">10.1093/hmg/dds425</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001869</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001869</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease</title><author><name sortKey="Amin Al Olama, Ali" sort="Amin Al Olama, Ali" uniqKey="Amin Al Olama A" first="Ali" last="Amin Al Olama">Ali Amin Al Olama</name><affiliation><nlm:aff id="af1"><addr-line>Strangeways Laboratory</addr-line>,<institution>Centre for Cancer Genetic Epidemiology</institution>,<addr-line>Worts Causeway, Cambridge CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation><nlm:aff id="af3"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Centre</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation><nlm:aff id="af4"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institute</institution>,<addr-line>Stockholm SE-171 77</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation><nlm:aff id="af5"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute, NIH</institution>,<addr-line>Bethesda, MD 20892</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af6"><addr-line>Core Genotyping Facility</addr-line>,<institution>SAIC-Frederick, Inc., National Cancer Institute, NIH</institution>,<addr-line>Gaithersburg, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Benlloch, Sara" sort="Benlloch, Sara" uniqKey="Benlloch S" first="Sara" last="Benlloch">Sara Benlloch</name><affiliation><nlm:aff id="af1"><addr-line>Strangeways Laboratory</addr-line>,<institution>Centre for Cancer Genetic Epidemiology</institution>,<addr-line>Worts Causeway, Cambridge CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="af7"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>1 Rathdowne Street, Carlton, VIC 3053</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af8"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>723 Swanston Street, Carlton, VIC 3053</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="af7"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>1 Rathdowne Street, Carlton, VIC 3053</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af8"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>723 Swanston Street, Carlton, VIC 3053</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><affiliation><nlm:aff id="af9"><addr-line>Surgical Oncology (Uro-Oncology: S4)</addr-line>,<institution>Addenbrooke's Hospital, University of Cambridge</institution>,<addr-line>Box 279, Hills Road, Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af10"><institution>Li Ka Shing Centre, Cancer Research UK Cambridge Research Institute</institution>,<addr-line>Cambridge CB2 2QQ</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C." last="Hamdy">Freddie C. Hamdy</name><affiliation><nlm:aff wicri:cut=" and" id="af11"><addr-line>Nuffield Department of Surgery</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af13"><addr-line>Faculty of Medical Science</addr-line>,<institution>University of Oxford, John Radcliffe Hospital</institution>,<addr-line>Oxford OX3 9DU</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L." last="Donovan">Jenny L. Donovan</name><affiliation><nlm:aff id="af14"><addr-line>School of Social and Community Medicine</addr-line>,<institution>University of Bristol</institution>,<addr-line>Canynge Hall, 39 Whatley Road, Bristol BS8 2PS</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Program in Molecular and Genetic Epidemiology, Department of Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="af3"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Centre</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Thun, Michael J" sort="Thun, Michael J" uniqKey="Thun M" first="Michael J." last="Thun">Michael J. Thun</name><affiliation><nlm:aff id="af17"><addr-line>Epidemiology Research Program</addr-line>,<institution>American Cancer Society</institution>,<addr-line>Atlanta, GA 30303</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Gaziano, Michael" sort="Gaziano, Michael" uniqKey="Gaziano M" first="Michael" last="Gaziano">Michael Gaziano</name><affiliation><nlm:aff id="af18"><institution>Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) and Geriatric Research, Education, and Clinical Center (GRECC), Boston Veterans Affairs Healthcare System</institution>,<addr-line>Boston, MA 02114</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af19"><addr-line>Division of Aging, Department of Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA 02215</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name><affiliation><nlm:aff id="af16"><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Siddiq, Afshan" sort="Siddiq, Afshan" uniqKey="Siddiq A" first="Afshan" last="Siddiq">Afshan Siddiq</name><affiliation><nlm:aff id="af20"><addr-line>Department of Genomics of Common Disease</addr-line>,<institution>School of Public Health, Imperial College</institution>,<addr-line>London SW7 2AZ</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="af12"><addr-line>Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Cox, David G" sort="Cox, David G" uniqKey="Cox D" first="David G." last="Cox">David G. Cox</name><affiliation><nlm:aff id="af21"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>School of Public Health, Imperial College London</institution>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af22"><addr-line>Lyon Cancer Research Center</addr-line>,<institution>INSERM U1052</institution>,<addr-line>Lyon</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation><nlm:aff id="af23"><addr-line>Genomic Epidemiology Group</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:aff id="af21"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>School of Public Health, Imperial College London</institution>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J." last="Key">Timothy J. Key</name><affiliation><nlm:aff id="af12"><addr-line>Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Andriole, Gerald" sort="Andriole, Gerald" uniqKey="Andriole G" first="Gerald" last="Andriole">Gerald Andriole</name><affiliation><nlm:aff id="af26"><addr-line>Division of Urologic Surgery</addr-line>,<institution>Washington University School of Medicine</institution>,<addr-line>St Louis, MO</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation><nlm:aff id="af5"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute, NIH</institution>,<addr-line>Bethesda, MD 20892</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B." last="Hayes">Richard B. Hayes</name><affiliation><nlm:aff id="af27"><addr-line>Division of Epidemiology, Department of Environmental Medicine</addr-line>,<institution>NYU Langone Medical Centre, NYU Cancer Institute</institution>,<addr-line>New York, NY 10016</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Schleutker, Johanna" sort="Schleutker, Johanna" uniqKey="Schleutker J" first="Johanna" last="Schleutker">Johanna Schleutker</name><affiliation><nlm:aff wicri:cut=" and" id="af28"><institution>Institute of Biomedical Technology/BioMediTech, University of Tampere</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af32"><addr-line>Department of Medical Biochemistry and Genetics</addr-line>,<institution>University of Turku</institution>,<addr-line>Turku</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Auvinen, Anssi" sort="Auvinen, Anssi" uniqKey="Auvinen A" first="Anssi" last="Auvinen">Anssi Auvinen</name><affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Department of Epidemiology</addr-line>,<institution>School of Health Sciences</institution></nlm:aff></affiliation></author><author><name sortKey="Tammela, Teuvo L J" sort="Tammela, Teuvo L J" uniqKey="Tammela T" first="Teuvo L. J." last="Tammela">Teuvo L. J. Tammela</name><affiliation><nlm:aff id="af31"><addr-line>Department of Urology</addr-line>,<institution>Tampere University Hospital and Medical School, University of Tampere</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Weischer, Maren" sort="Weischer, Maren" uniqKey="Weischer M" first="Maren" last="Weischer">Maren Weischer</name><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Clinical Biochemistry</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stanford, Janet L" sort="Stanford, Janet L" uniqKey="Stanford J" first="Janet L." last="Stanford">Janet L. Stanford</name><affiliation><nlm:aff id="af35"><addr-line>Division of Public Health Sciences</addr-line>,<institution>Fred Hutchinson Cancer Research Centre</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af36"><addr-line>Department of Epidemiology</addr-line>,<institution>School of Public Health, University of Washington</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ostrander, Elaine A" sort="Ostrander, Elaine A" uniqKey="Ostrander E" first="Elaine A." last="Ostrander">Elaine A. Ostrander</name><affiliation><nlm:aff id="af37"><institution>National Human Genome Research Institute, National Institutes of Health</institution>,<addr-line>50 South Drive, Room 5351, Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name><affiliation><nlm:aff id="af38"><addr-line>Department of Genetics and Pathology, International Hereditary Cancer Center</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="af38"><addr-line>Department of Genetics and Pathology, International Hereditary Cancer Center</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Thibodeau, Stephen N" sort="Thibodeau, Stephen N" uniqKey="Thibodeau S" first="Stephen N." last="Thibodeau">Stephen N. Thibodeau</name><affiliation><nlm:aff id="af39"><institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Schaid, Daniel J" sort="Schaid, Daniel J" uniqKey="Schaid D" first="Daniel J." last="Schaid">Daniel J. Schaid</name><affiliation><nlm:aff id="af39"><institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Sorensen, Karina D" sort="Sorensen, Karina D" uniqKey="Sorensen K" first="Karina D." last="Sorensen">Karina D. Sorensen</name><affiliation><nlm:aff wicri:cut=" and" id="af40"><addr-line>Department of Molecular Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Batra, Jyotsna" sort="Batra, Jyotsna" uniqKey="Batra J" first="Jyotsna" last="Batra">Jyotsna Batra</name><affiliation><nlm:aff id="af42"><institution>Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation, Queensland University of Technology</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Clements, Judith A" sort="Clements, Judith A" uniqKey="Clements J" first="Judith A." last="Clements">Judith A. Clements</name><affiliation><nlm:aff id="af42"><institution>Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation, Queensland University of Technology</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Chambers, Suzanne" sort="Chambers, Suzanne" uniqKey="Chambers S" first="Suzanne" last="Chambers">Suzanne Chambers</name><affiliation><nlm:aff id="af43"><institution>Griffith Health Institute, Griffith University</institution>,<addr-line>Gold Coast, QLD</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af44"><institution>Viertel Centre for Research in Cancer Control, Cancer Council Queensland</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af45"><institution>Centre for Clinical Research, University of Queensland</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Aitken, Joanne" sort="Aitken, Joanne" uniqKey="Aitken J" first="Joanne" last="Aitken">Joanne Aitken</name><affiliation><nlm:aff id="af44"><institution>Viertel Centre for Research in Cancer Control, Cancer Council Queensland</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Gardiner, Robert A" sort="Gardiner, Robert A" uniqKey="Gardiner R" first="Robert A." last="Gardiner">Robert A. Gardiner</name><affiliation><nlm:aff id="af45"><institution>Centre for Clinical Research, University of Queensland</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Maier, Christiane" sort="Maier, Christiane" uniqKey="Maier C" first="Christiane" last="Maier">Christiane Maier</name><affiliation><nlm:aff wicri:cut=" and" id="af46"><addr-line>Department of Urology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af47"><institution>Institute of Human Genetics, University Hospital Ulm</institution>,<addr-line>Ulm</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Vogel, Walther" sort="Vogel, Walther" uniqKey="Vogel W" first="Walther" last="Vogel">Walther Vogel</name><affiliation><nlm:aff id="af47"><institution>Institute of Human Genetics, University Hospital Ulm</institution>,<addr-line>Ulm</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="af48"><institution>Hannover Medical School</institution>,<addr-line>Hannover</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff wicri:cut=" and" id="af24"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation></author><author><name sortKey="Habuchi, Tomonori" sort="Habuchi, Tomonori" uniqKey="Habuchi T" first="Tomonori" last="Habuchi">Tomonori Habuchi</name><affiliation><nlm:aff id="af49"><addr-line>Department of Urology,</addr-line><institution>Akita University Graduate School of Medicine</institution>,<addr-line>1-1-1 Hondo, Akita 010-8543</addr-line>,<country>Japan</country>,</nlm:aff></affiliation></author><author><name sortKey="Ingles, Sue" sort="Ingles, Sue" uniqKey="Ingles S" first="Sue" last="Ingles">Sue Ingles</name><affiliation><nlm:aff id="af3"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Centre</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="af50"><institution>Cancer Prevention Institute of California</institution>,<addr-line>Fremont</addr-line>, CA,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af51"><institution>Division of Epidemiology, Department of Health Research and Policy and Stanford Cancer Institute, Stanford University School of Medicine</institution>,<addr-line>Stanford, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Dickinson, Joanne L" sort="Dickinson, Joanne L" uniqKey="Dickinson J" first="Joanne L." last="Dickinson">Joanne L. Dickinson</name><affiliation><nlm:aff id="af52"><institution>Menzies Research Institute Tasmania, University of Tasmania</institution>,<addr-line>Hobart, TAS</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Cannon Albright, Lisa" sort="Cannon Albright, Lisa" uniqKey="Cannon Albright L" first="Lisa" last="Cannon-Albright">Lisa Cannon-Albright</name><affiliation><nlm:aff id="af53"><addr-line>Division of Genetic Epidemiology, Department of Internal Medicine</addr-line>,<institution>University of Utah School of Medicine</institution>,<addr-line>Salt Lake City, UT</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af54"><addr-line>George E. Wahlen Department of Veterans Affairs Medical Centre, Salt Lake City, UT</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R." last="Teixeira">Manuel R. Teixeira</name><affiliation><nlm:aff id="af55"><addr-line>Department of Genetics</addr-line>,<institution>Portuguese Oncology Institute and Biomedical Sciences Institute (ICBAS), Porto University</institution>,<addr-line>Porto</addr-line>,<country>Portugal</country>,</nlm:aff></affiliation></author><author><name sortKey="Kaneva, Radka" sort="Kaneva, Radka" uniqKey="Kaneva R" first="Radka" last="Kaneva">Radka Kaneva</name><affiliation><nlm:aff id="af56"><addr-line>Molecular Medicine Centre, Department of Medical Chemistry and Biochemistry</addr-line>,<institution>Medical University of Sofia</institution>,<addr-line>2 Zdrave St, Sofia 1431</addr-line>,<country>Bulgaria</country>,</nlm:aff></affiliation></author><author><name sortKey="Zhang, Hong Wei" sort="Zhang, Hong Wei" uniqKey="Zhang H" first="Hong-Wei" last="Zhang">Hong-Wei Zhang</name><affiliation><nlm:aff id="af57"><addr-line>Department of Epidemiology</addr-line>,<institution>Second Military Medical University</institution>,<addr-line>Shanghai</addr-line>,<country>China</country>,</nlm:aff></affiliation></author><author><name sortKey="Lu, Yong Jie" sort="Lu, Yong Jie" uniqKey="Lu Y" first="Yong-Jie" last="Lu">Yong-Jie Lu</name><affiliation><nlm:aff id="af58"><institution>Centre for Molecular Oncology and Imaging, Barts Cancer Institute, Queen Mary University of London</institution>,<addr-line>Charterhouse Square, London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Park, Jong Y" sort="Park, Jong Y" uniqKey="Park J" first="Jong Y." last="Park">Jong Y. Park</name><affiliation><nlm:aff id="af59"><addr-line>Division of Cancer Prevention and Control</addr-line>,<institution>H. Lee Moffitt Cancer Centre</institution>,<addr-line>12902 Magnolia Drive, Tampa, FL</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Cooney, Kathleen A" sort="Cooney, Kathleen A" uniqKey="Cooney K" first="Kathleen A." last="Cooney">Kathleen A. Cooney</name><affiliation><nlm:aff wicri:cut=" and" id="af60"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af61"><addr-line>Department of Urology</addr-line>,<institution>University of Michigan Medical School</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth R" sort="Muir, Kenneth R" uniqKey="Muir K" first="Kenneth R." last="Muir">Kenneth R. Muir</name><affiliation><nlm:aff id="af62"><institution>Warwick Medical School, University of Warwick</institution>,<addr-line>Coventry</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Leongamornlert, Daniel A" sort="Leongamornlert, Daniel A" uniqKey="Leongamornlert D" first="Daniel A." last="Leongamornlert">Daniel A. Leongamornlert</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Saunders, Edward" sort="Saunders, Edward" uniqKey="Saunders E" first="Edward" last="Saunders">Edward Saunders</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Tymrakiewicz, Malgorzata" sort="Tymrakiewicz, Malgorzata" uniqKey="Tymrakiewicz M" first="Malgorzata" last="Tymrakiewicz">Malgorzata Tymrakiewicz</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Mahmud, Nadiya" sort="Mahmud, Nadiya" uniqKey="Mahmud N" first="Nadiya" last="Mahmud">Nadiya Mahmud</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Guy, Michelle" sort="Guy, Michelle" uniqKey="Guy M" first="Michelle" last="Guy">Michelle Guy</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Govindasami, Koveela" sort="Govindasami, Koveela" uniqKey="Govindasami K" first="Koveela" last="Govindasami">Koveela Govindasami</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="O Brien, Lynne T" sort="O Brien, Lynne T" uniqKey="O Brien L" first="Lynne T." last="O'Brien">Lynne T. O'Brien</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Wilkinson, Rosemary A" sort="Wilkinson, Rosemary A" uniqKey="Wilkinson R" first="Rosemary A." last="Wilkinson">Rosemary A. Wilkinson</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hall, Amanda L" sort="Hall, Amanda L" uniqKey="Hall A" first="Amanda L." last="Hall">Amanda L. Hall</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Emma J" sort="Sawyer, Emma J" uniqKey="Sawyer E" first="Emma J." last="Sawyer">Emma J. Sawyer</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Dadaev, Tokhir" sort="Dadaev, Tokhir" uniqKey="Dadaev T" first="Tokhir" last="Dadaev">Tokhir Dadaev</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Morrison, Jonathan" sort="Morrison, Jonathan" uniqKey="Morrison J" first="Jonathan" last="Morrison">Jonathan Morrison</name><affiliation><nlm:aff id="af1"><addr-line>Strangeways Laboratory</addr-line>,<institution>Centre for Cancer Genetic Epidemiology</institution>,<addr-line>Worts Causeway, Cambridge CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Dearnaley, David P" sort="Dearnaley, David P" uniqKey="Dearnaley D" first="David P." last="Dearnaley">David P. Dearnaley</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Horwich, Alan" sort="Horwich, Alan" uniqKey="Horwich A" first="Alan" last="Horwich">Alan Horwich</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Huddart, Robert A" sort="Huddart, Robert A" uniqKey="Huddart R" first="Robert A." last="Huddart">Robert A. Huddart</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Khoo, Vincent S" sort="Khoo, Vincent S" uniqKey="Khoo V" first="Vincent S." last="Khoo">Vincent S. Khoo</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Parker, Christopher C" sort="Parker, Christopher C" uniqKey="Parker C" first="Christopher C." last="Parker">Christopher C. Parker</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Van As, Nicholas" sort="Van As, Nicholas" uniqKey="Van As N" first="Nicholas" last="Van As">Nicholas Van As</name><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Woodhouse, Christopher J" sort="Woodhouse, Christopher J" uniqKey="Woodhouse C" first="Christopher J." last="Woodhouse">Christopher J. Woodhouse</name><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Thompson, Alan" sort="Thompson, Alan" uniqKey="Thompson A" first="Alan" last="Thompson">Alan Thompson</name><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Dudderidge, Tim" sort="Dudderidge, Tim" uniqKey="Dudderidge T" first="Tim" last="Dudderidge">Tim Dudderidge</name><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Ogden, Chris" sort="Ogden, Chris" uniqKey="Ogden C" first="Chris" last="Ogden">Chris Ogden</name><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Cooper, Colin S" sort="Cooper, Colin S" uniqKey="Cooper C" first="Colin S." last="Cooper">Colin S. Cooper</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Lophatonanon, Artitaya" sort="Lophatonanon, Artitaya" uniqKey="Lophatonanon A" first="Artitaya" last="Lophatonanon">Artitaya Lophatonanon</name><affiliation><nlm:aff id="af62"><institution>Warwick Medical School, University of Warwick</institution>,<addr-line>Coventry</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="af64"><addr-line>Genetic Epidemiology Laboratory, Department of Pathology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Grattan street, Parkville, VIC</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="af65"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>1 Rathdowne Street, Carlton, VIC</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="English, Dallas" sort="English, Dallas" uniqKey="English D" first="Dallas" last="English">Dallas English</name><affiliation><nlm:aff id="af65"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>1 Rathdowne Street, Carlton, VIC</addr-line>,<country>Australia</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af66"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>723 Swanston Street, Carlton, VIC</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation><nlm:aff id="af67"><addr-line>Department of Chronic Disease Prevention</addr-line>,<institution>National Institute for Health and Welfare</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="af68"><addr-line>Epidemiology Program, University of Hawaii Cancer Centre, Department of Medicine, John A. Burns School of Medicine</addr-line>,<institution>University of Hawaii</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Campa, Daniele" sort="Campa, Daniele" uniqKey="Campa D" first="Daniele" last="Campa">Daniele Campa</name><affiliation><nlm:aff id="af22"><addr-line>Lyon Cancer Research Center</addr-line>,<institution>INSERM U1052</institution>,<addr-line>Lyon</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:aff id="af25"><addr-line>Division of Cancer Epidemiology</addr-line>,<institution>German Cancer Research Centre (DKFZ)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Program in Molecular and Genetic Epidemiology, Department of Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name><affiliation><nlm:aff id="af17"><addr-line>Epidemiology Research Program</addr-line>,<institution>American Cancer Society</institution>,<addr-line>Atlanta, GA 30303</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Gapstur, Susan" sort="Gapstur, Susan" uniqKey="Gapstur S" first="Susan" last="Gapstur">Susan Gapstur</name><affiliation><nlm:aff id="af17"><addr-line>Epidemiology Research Program</addr-line>,<institution>American Cancer Society</institution>,<addr-line>Atlanta, GA 30303</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Yeager, Meredith" sort="Yeager, Meredith" uniqKey="Yeager M" first="Meredith" last="Yeager">Meredith Yeager</name><affiliation><nlm:aff id="af5"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute, NIH</institution>,<addr-line>Bethesda, MD 20892</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af6"><addr-line>Core Genotyping Facility</addr-line>,<institution>SAIC-Frederick, Inc., National Cancer Institute, NIH</institution>,<addr-line>Gaithersburg, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="af69"><addr-line>Department of Oncology</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Stern, Mariana C" sort="Stern, Mariana C" uniqKey="Stern M" first="Mariana C." last="Stern">Mariana C. Stern</name><affiliation><nlm:aff id="af3"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Centre</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Corral, Roman" sort="Corral, Roman" uniqKey="Corral R" first="Roman" last="Corral">Roman Corral</name><affiliation><nlm:aff id="af3"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Centre</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Aly, Markus" sort="Aly, Markus" uniqKey="Aly M" first="Markus" last="Aly">Markus Aly</name><affiliation><nlm:aff id="af4"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institute</institution>,<addr-line>Stockholm SE-171 77</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af70"><addr-line>Division of Urology, Department of Clinical Sciences</addr-line>,<institution>Danderyd Hospital</institution></nlm:aff></affiliation></author><author><name sortKey="Isaacs, William" sort="Isaacs, William" uniqKey="Isaacs W" first="William" last="Isaacs">William Isaacs</name><affiliation><nlm:aff id="af72"><addr-line>School of Medicine</addr-line>,<institution>Johns Hopkins University</institution>,<addr-line>115 Marburg Building, 600 North Wolfe Street, Baltimore, MD 21205</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Adolfsson, Jan" sort="Adolfsson, Jan" uniqKey="Adolfsson J" first="Jan" last="Adolfsson">Jan Adolfsson</name><affiliation><nlm:aff id="af71"><institution>Oncological Centre, CLINTEC, Karolinska Institute</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Xu, Jianfeng" sort="Xu, Jianfeng" uniqKey="Xu J" first="Jianfeng" last="Xu">Jianfeng Xu</name><affiliation><nlm:aff id="af73"><institution>Center for Cancer Genomics, Wake Forest University School of Medicine, Medical Center Boulevard</institution>,<addr-line>Winston-Salem, NC 27157</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Zheng, S Lilly" sort="Zheng, S Lilly" uniqKey="Zheng S" first="S. Lilly" last="Zheng">S. Lilly Zheng</name><affiliation><nlm:aff id="af73"><institution>Center for Cancer Genomics, Wake Forest University School of Medicine, Medical Center Boulevard</institution>,<addr-line>Winston-Salem, NC 27157</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wahlfors, Tiina" sort="Wahlfors, Tiina" uniqKey="Wahlfors T" first="Tiina" last="Wahlfors">Tiina Wahlfors</name><affiliation><nlm:aff id="af31"><addr-line>Department of Urology</addr-line>,<institution>Tampere University Hospital and Medical School, University of Tampere</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Taari, Kimmo" sort="Taari, Kimmo" uniqKey="Taari K" first="Kimmo" last="Taari">Kimmo Taari</name><affiliation><nlm:aff id="af74"><addr-line>Department of Urology</addr-line>,<institution>Helsinki University Central Hospital, University of Helsinki</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Kujala, Paula" sort="Kujala, Paula" uniqKey="Kujala P" first="Paula" last="Kujala">Paula Kujala</name><affiliation><nlm:aff id="af29"><addr-line>Department of Pathology, Centre for Laboratory Medicine</addr-line>,<institution>Tampere University Hospital</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Klarskov, Peter" sort="Klarskov, Peter" uniqKey="Klarskov P" first="Peter" last="Klarskov">Peter Klarskov</name><affiliation><nlm:aff id="af34"><addr-line>Department of Urology</addr-line>,<institution>Herlev Hospital, Copenhagen University Hospital</institution>,<addr-line>Herlev Ringvej 75, Herlev DK-2730</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Clinical Biochemistry</addr-line></nlm:aff></affiliation></author><author><name sortKey="R Der, M Andreas" sort="R Der, M Andreas" uniqKey="R Der M" first="M. Andreas" last="R Der">M. Andreas R Der</name><affiliation><nlm:aff wicri:cut=" and" id="af75"><addr-line>Department of Urology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Frikke Schmidt, Ruth" sort="Frikke Schmidt, Ruth" uniqKey="Frikke Schmidt R" first="Ruth" last="Frikke-Schmidt">Ruth Frikke-Schmidt</name><affiliation><nlm:aff id="af76"><addr-line>Department of Clinical Biochemistry</addr-line>,<institution>Rigshospitalet, Copenhagen University Hospital</institution>,<addr-line>Blegdamsvej 9, Copenhagen DK-2100</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Clinical Biochemistry</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M." last="Fitzgerald">Liesel M. Fitzgerald</name><affiliation><nlm:aff id="af35"><addr-line>Division of Public Health Sciences</addr-line>,<institution>Fred Hutchinson Cancer Research Centre</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Kolb, Suzanne" sort="Kolb, Suzanne" uniqKey="Kolb S" first="Suzanne" last="Kolb">Suzanne Kolb</name><affiliation><nlm:aff id="af35"><addr-line>Division of Public Health Sciences</addr-line>,<institution>Fred Hutchinson Cancer Research Centre</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Kwon, Erika M" sort="Kwon, Erika M" uniqKey="Kwon E" first="Erika M." last="Kwon">Erika M. Kwon</name><affiliation><nlm:aff id="af37"><institution>National Human Genome Research Institute, National Institutes of Health</institution>,<addr-line>50 South Drive, Room 5351, Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Karyadi, Danielle M" sort="Karyadi, Danielle M" uniqKey="Karyadi D" first="Danielle M." last="Karyadi">Danielle M. Karyadi</name><affiliation><nlm:aff id="af37"><institution>National Human Genome Research Institute, National Institutes of Health</institution>,<addr-line>50 South Drive, Room 5351, Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Orntoft, Torben Falck" sort="Orntoft, Torben Falck" uniqKey="Orntoft T" first="Torben Falck" last="Orntoft">Torben Falck Orntoft</name><affiliation><nlm:aff wicri:cut=" and" id="af40"><addr-line>Department of Molecular Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Borre, Michael" sort="Borre, Michael" uniqKey="Borre M" first="Michael" last="Borre">Michael Borre</name><affiliation><nlm:aff id="af41"><addr-line>Department of Urology</addr-line>,<institution>Aarhus University Hospital</institution>,<addr-line>Skejby</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Rinckleb, Antje" sort="Rinckleb, Antje" uniqKey="Rinckleb A" first="Antje" last="Rinckleb">Antje Rinckleb</name><affiliation><nlm:aff wicri:cut=" and" id="af46"><addr-line>Department of Urology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Luedeke, Manuel" sort="Luedeke, Manuel" uniqKey="Luedeke M" first="Manuel" last="Luedeke">Manuel Luedeke</name><affiliation><nlm:aff id="af47"><institution>Institute of Human Genetics, University Hospital Ulm</institution>,<addr-line>Ulm</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Herkommer, Kathleen" sort="Herkommer, Kathleen" uniqKey="Herkommer K" first="Kathleen" last="Herkommer">Kathleen Herkommer</name><affiliation><nlm:aff id="af77"><addr-line>Department of Urology</addr-line>,<institution>Rechts der Isar Medical Centre, Technical University of Munich</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Meyer, Andreas" sort="Meyer, Andreas" uniqKey="Meyer A" first="Andreas" last="Meyer">Andreas Meyer</name><affiliation><nlm:aff id="af48"><institution>Hannover Medical School</institution>,<addr-line>Hannover</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Serth, Jurgen" sort="Serth, Jurgen" uniqKey="Serth J" first="Jürgen" last="Serth">Jürgen Serth</name><affiliation><nlm:aff id="af48"><institution>Hannover Medical School</institution>,<addr-line>Hannover</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Marthick, James R" sort="Marthick, James R" uniqKey="Marthick J" first="James R." last="Marthick">James R. Marthick</name><affiliation><nlm:aff id="af52"><institution>Menzies Research Institute Tasmania, University of Tasmania</institution>,<addr-line>Hobart, TAS</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Patterson, Briony" sort="Patterson, Briony" uniqKey="Patterson B" first="Briony" last="Patterson">Briony Patterson</name><affiliation><nlm:aff id="af52"><institution>Menzies Research Institute Tasmania, University of Tasmania</institution>,<addr-line>Hobart, TAS</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Wokolorczyk, Dominika" sort="Wokolorczyk, Dominika" uniqKey="Wokolorczyk D" first="Dominika" last="Wokolorczyk">Dominika Wokolorczyk</name><affiliation><nlm:aff id="af38"><addr-line>Department of Genetics and Pathology, International Hereditary Cancer Center</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda" sort="Spurdle, Amanda" uniqKey="Spurdle A" first="Amanda" last="Spurdle">Amanda Spurdle</name><affiliation><nlm:aff wicri:cut=" and" id="af79"><institution>Huntsman Cancer Institute</institution>,<addr-line>Salt Lake City, UT</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lose, Felicity" sort="Lose, Felicity" uniqKey="Lose F" first="Felicity" last="Lose">Felicity Lose</name><affiliation><nlm:aff id="af78"><addr-line>Molecular Cancer Epidemiology Laboratory</addr-line>,<institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Mcdonnell, Shannon K" sort="Mcdonnell, Shannon K" uniqKey="Mcdonnell S" first="Shannon K." last="Mcdonnell">Shannon K. Mcdonnell</name><affiliation><nlm:aff id="af39"><institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Joshi, Amit D" sort="Joshi, Amit D" uniqKey="Joshi A" first="Amit D." last="Joshi">Amit D. Joshi</name><affiliation><nlm:aff id="af3"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Centre</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Shahabi, Ahva" sort="Shahabi, Ahva" uniqKey="Shahabi A" first="Ahva" last="Shahabi">Ahva Shahabi</name><affiliation><nlm:aff id="af3"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Centre</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Pinto, Pedro" sort="Pinto, Pedro" uniqKey="Pinto P" first="Pedro" last="Pinto">Pedro Pinto</name><affiliation><nlm:aff id="af55"><addr-line>Department of Genetics</addr-line>,<institution>Portuguese Oncology Institute and Biomedical Sciences Institute (ICBAS), Porto University</institution>,<addr-line>Porto</addr-line>,<country>Portugal</country>,</nlm:aff></affiliation></author><author><name sortKey="Santos, Joana" sort="Santos, Joana" uniqKey="Santos J" first="Joana" last="Santos">Joana Santos</name><affiliation><nlm:aff id="af55"><addr-line>Department of Genetics</addr-line>,<institution>Portuguese Oncology Institute and Biomedical Sciences Institute (ICBAS), Porto University</institution>,<addr-line>Porto</addr-line>,<country>Portugal</country>,</nlm:aff></affiliation></author><author><name sortKey="Ray, Ana" sort="Ray, Ana" uniqKey="Ray A" first="Ana" last="Ray">Ana Ray</name><affiliation><nlm:aff wicri:cut=" and" id="af60"><addr-line>Department of Internal Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af61"><addr-line>Department of Urology</addr-line>,<institution>University of Michigan Medical School</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name><affiliation><nlm:aff id="af59"><addr-line>Division of Cancer Prevention and Control</addr-line>,<institution>H. Lee Moffitt Cancer Centre</institution>,<addr-line>12902 Magnolia Drive, Tampa, FL</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lin, Hui Yi" sort="Lin, Hui Yi" uniqKey="Lin H" first="Hui-Yi" last="Lin">Hui-Yi Lin</name><affiliation><nlm:aff id="af59"><addr-line>Division of Cancer Prevention and Control</addr-line>,<institution>H. Lee Moffitt Cancer Centre</institution>,<addr-line>12902 Magnolia Drive, Tampa, FL</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Stephenson, Robert A" sort="Stephenson, Robert A" uniqKey="Stephenson R" first="Robert A." last="Stephenson">Robert A. Stephenson</name><affiliation><nlm:aff wicri:cut=" and" id="af79"><institution>Huntsman Cancer Institute</institution>,<addr-line>Salt Lake City, UT</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Teerlink, Craig" sort="Teerlink, Craig" uniqKey="Teerlink C" first="Craig" last="Teerlink">Craig Teerlink</name><affiliation><nlm:aff id="af53"><addr-line>Division of Genetic Epidemiology, Department of Internal Medicine</addr-line>,<institution>University of Utah School of Medicine</institution>,<addr-line>Salt Lake City, UT</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Muller">Heiko Muller</name><affiliation><nlm:aff wicri:cut=" and" id="af24"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rothenbacher, Dietrich" sort="Rothenbacher, Dietrich" uniqKey="Rothenbacher D" first="Dietrich" last="Rothenbacher">Dietrich Rothenbacher</name><affiliation><nlm:aff wicri:cut=" and" id="af24"><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tsuchiya, Norihiko" sort="Tsuchiya, Norihiko" uniqKey="Tsuchiya N" first="Norihiko" last="Tsuchiya">Norihiko Tsuchiya</name><affiliation><nlm:aff id="af49"><addr-line>Department of Urology,</addr-line><institution>Akita University Graduate School of Medicine</institution>,<addr-line>1-1-1 Hondo, Akita 010-8543</addr-line>,<country>Japan</country>,</nlm:aff></affiliation></author><author><name sortKey="Narita, Shintaro" sort="Narita, Shintaro" uniqKey="Narita S" first="Shintaro" last="Narita">Shintaro Narita</name><affiliation><nlm:aff id="af49"><addr-line>Department of Urology,</addr-line><institution>Akita University Graduate School of Medicine</institution>,<addr-line>1-1-1 Hondo, Akita 010-8543</addr-line>,<country>Japan</country>,</nlm:aff></affiliation></author><author><name sortKey="Cao, Guang Wen" sort="Cao, Guang Wen" uniqKey="Cao G" first="Guang-Wen" last="Cao">Guang-Wen Cao</name><affiliation><nlm:aff id="af57"><addr-line>Department of Epidemiology</addr-line>,<institution>Second Military Medical University</institution>,<addr-line>Shanghai</addr-line>,<country>China</country>,</nlm:aff></affiliation></author><author><name sortKey="Slavov, Chavdar" sort="Slavov, Chavdar" uniqKey="Slavov C" first="Chavdar" last="Slavov">Chavdar Slavov</name><affiliation><nlm:aff id="af80"><addr-line>Department of Urology and Alexandrovska University Hospital,</addr-line><institution>Medical University of Sofia</institution>,<addr-line>Sofia</addr-line>,<country>Bulgaria</country></nlm:aff></affiliation></author><author><name sortKey="Mitev, Vanio" sort="Mitev, Vanio" uniqKey="Mitev V" first="Vanio" last="Mitev">Vanio Mitev</name><affiliation><nlm:aff id="af56"><addr-line>Molecular Medicine Centre, Department of Medical Chemistry and Biochemistry</addr-line>,<institution>Medical University of Sofia</institution>,<addr-line>2 Zdrave St, Sofia 1431</addr-line>,<country>Bulgaria</country>,</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen" sort="Chanock, Stephen" uniqKey="Chanock S" first="Stephen" last="Chanock">Stephen Chanock</name><affiliation><nlm:aff id="af6"><addr-line>Core Genotyping Facility</addr-line>,<institution>SAIC-Frederick, Inc., National Cancer Institute, NIH</institution>,<addr-line>Gaithersburg, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Gronberg">Henrik Gronberg</name><affiliation><nlm:aff id="af4"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institute</institution>,<addr-line>Stockholm SE-171 77</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="af3"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Centre</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Program in Molecular and Genetic Epidemiology, Department of Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="af1"><addr-line>Strangeways Laboratory</addr-line>,<institution>Centre for Cancer Genetic Epidemiology</institution>,<addr-line>Worts Causeway, Cambridge CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation><nlm:aff id="af2"><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af63"><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author></analytic><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03–1.21), <italic>P</italic> = 1.4 × 10<sup>−8</sup>]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Mol Genet</journal-id><journal-id journal-id-type="iso-abbrev">Hum. Mol. Genet</journal-id><journal-id journal-id-type="publisher-id">hmg</journal-id><journal-id journal-id-type="hwp">hmg</journal-id><journal-title-group><journal-title>Human Molecular Genetics</journal-title></journal-title-group><issn pub-type="ppub">0964-6906</issn><issn pub-type="epub">1460-2083</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23065704</article-id><article-id pub-id-type="pmc">3526158</article-id><article-id pub-id-type="doi">10.1093/hmg/dds425</article-id><article-id pub-id-type="publisher-id">dds425</article-id><article-categories><subj-group subj-group-type="heading"><subject>Association Studies Articles</subject></subj-group></article-categories><title-group><article-title>A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive 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contrib-type="author"><name><surname>Serth</surname><given-names>Jürgen</given-names></name><xref ref-type="aff" rid="af48">48</xref></contrib><contrib contrib-type="author"><name><surname>Marthick</surname><given-names>James R.</given-names></name><xref ref-type="aff" rid="af52">52</xref></contrib><contrib contrib-type="author"><name><surname>Patterson</surname><given-names>Briony</given-names></name><xref ref-type="aff" rid="af52">52</xref></contrib><contrib contrib-type="author"><name><surname>Wokolorczyk</surname><given-names>Dominika</given-names></name><xref ref-type="aff" rid="af38">38</xref></contrib><contrib contrib-type="author"><name><surname>Spurdle</surname><given-names>Amanda</given-names></name><xref ref-type="aff" rid="af79">79</xref></contrib><contrib contrib-type="author"><name><surname>Lose</surname><given-names>Felicity</given-names></name><xref ref-type="aff" rid="af78">78</xref></contrib><contrib contrib-type="author"><name><surname>McDonnell</surname><given-names>Shannon K.</given-names></name><xref ref-type="aff" rid="af39">39</xref></contrib><contrib contrib-type="author"><name><surname>Joshi</surname><given-names>Amit D.</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Shahabi</surname><given-names>Ahva</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Pinto</surname><given-names>Pedro</given-names></name><xref ref-type="aff" rid="af55">55</xref></contrib><contrib contrib-type="author"><name><surname>Santos</surname><given-names>Joana</given-names></name><xref ref-type="aff" rid="af55">55</xref></contrib><contrib contrib-type="author"><name><surname>Ray</surname><given-names>Ana</given-names></name><xref ref-type="aff" rid="af60">60</xref><xref ref-type="aff" rid="af61">61</xref></contrib><contrib contrib-type="author"><name><surname>Sellers</surname><given-names>Thomas A.</given-names></name><xref ref-type="aff" rid="af59">59</xref></contrib><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Hui-Yi</given-names></name><xref ref-type="aff" rid="af59">59</xref></contrib><contrib contrib-type="author"><name><surname>Stephenson</surname><given-names>Robert A.</given-names></name><xref ref-type="aff" rid="af79">79</xref></contrib><contrib contrib-type="author"><name><surname>Teerlink</surname><given-names>Craig</given-names></name><xref ref-type="aff" rid="af53">53</xref></contrib><contrib contrib-type="author"><name><surname>Muller</surname><given-names>Heiko</given-names></name><xref ref-type="aff" rid="af24">24</xref></contrib><contrib contrib-type="author"><name><surname>Rothenbacher</surname><given-names>Dietrich</given-names></name><xref ref-type="aff" rid="af24">24</xref></contrib><contrib contrib-type="author"><name><surname>Tsuchiya</surname><given-names>Norihiko</given-names></name><xref ref-type="aff" rid="af49">49</xref></contrib><contrib contrib-type="author"><name><surname>Narita</surname><given-names>Shintaro</given-names></name><xref ref-type="aff" rid="af49">49</xref></contrib><contrib contrib-type="author"><name><surname>Cao</surname><given-names>Guang-Wen</given-names></name><xref ref-type="aff" rid="af57">57</xref></contrib><contrib contrib-type="author"><name><surname>Slavov</surname><given-names>Chavdar</given-names></name><xref ref-type="aff" rid="af80">80</xref></contrib><contrib contrib-type="author"><name><surname>Mitev</surname><given-names>Vanio</given-names></name><xref ref-type="aff" rid="af56">56</xref></contrib><contrib contrib-type="author"><collab>The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology</collab><xref ref-type="author-notes" rid="AN3">¶</xref></contrib><contrib contrib-type="author"><collab>The UK ProtecT Study Collaborators</collab><xref ref-type="author-notes" rid="AN4">§</xref></contrib><contrib contrib-type="author"><collab>The Australian Prostate Cancer Bioresource</collab><xref ref-type="author-notes" rid="AN5">‖</xref></contrib><contrib contrib-type="author"><collab>The PRACTICAL Consortium</collab><xref ref-type="author-notes" rid="AN6">#</xref></contrib><contrib contrib-type="author"><name><surname>Chanock</surname><given-names>Stephen</given-names></name><xref ref-type="aff" rid="af6">6</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Gronberg</surname><given-names>Henrik</given-names></name><xref ref-type="aff" rid="af4">4</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Haiman</surname><given-names>Christopher A.</given-names></name><xref ref-type="aff" rid="af3">3</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Kraft</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="af15">15</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Eeles</surname><given-names>Rosalind A.</given-names></name><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af63">63</xref><xref ref-type="corresp" rid="cor1">*</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>Strangeways Laboratory</addr-line>,<institution>Centre for Cancer Genetic Epidemiology</institution>,<addr-line>Worts Causeway, Cambridge CB1 8RN</addr-line>,<country>UK</country>,</aff><aff id="af2"><label>2</label><institution>The Institute of Cancer Research</institution>,<addr-line>15 Cotswold Road, Sutton, Surrey SM2 5NG</addr-line>,<country>UK</country>,</aff><aff id="af3"><label>3</label><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Centre</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</aff><aff id="af4"><label>4</label><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institute</institution>,<addr-line>Stockholm SE-171 77</addr-line>,<country>Sweden</country>,</aff><aff id="af5"><label>5</label><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute, NIH</institution>,<addr-line>Bethesda, MD 20892</addr-line>,<country>USA</country>,</aff><aff id="af6"><label>6</label><addr-line>Core Genotyping Facility</addr-line>,<institution>SAIC-Frederick, Inc., National Cancer Institute, NIH</institution>,<addr-line>Gaithersburg, MD</addr-line>,<country>USA</country>,</aff><aff id="af7"><label>7</label><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>1 Rathdowne Street, Carlton, VIC 3053</addr-line>,<country>Australia</country>,</aff><aff id="af8"><label>8</label><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>723 Swanston Street, Carlton, VIC 3053</addr-line>,<country>Australia</country>,</aff><aff id="af9"><label>9</label><addr-line>Surgical Oncology (Uro-Oncology: S4)</addr-line>,<institution>Addenbrooke's Hospital, University of Cambridge</institution>,<addr-line>Box 279, Hills Road, Cambridge</addr-line>,<country>UK</country>,</aff><aff id="af10"><label>10</label><institution>Li Ka Shing Centre, Cancer Research UK Cambridge Research Institute</institution>,<addr-line>Cambridge CB2 2QQ</addr-line>,<country>UK</country>,</aff><aff id="af11"><label>11</label><addr-line>Nuffield Department of Surgery</addr-line> and</aff><aff id="af12"><label>12</label><addr-line>Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</aff><aff id="af13"><label>13</label><addr-line>Faculty of Medical Science</addr-line>,<institution>University of Oxford, John Radcliffe Hospital</institution>,<addr-line>Oxford OX3 9DU</addr-line>,<country>UK</country>,</aff><aff id="af14"><label>14</label><addr-line>School of Social and Community Medicine</addr-line>,<institution>University of Bristol</institution>,<addr-line>Canynge Hall, 39 Whatley Road, Bristol BS8 2PS</addr-line>,<country>UK</country>,</aff><aff id="af15"><label>15</label><addr-line>Program in Molecular and Genetic Epidemiology, Department of Epidemiology</addr-line> and</aff><aff id="af16"><label>16</label><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston, MA 02115</addr-line>,<country>USA</country>,</aff><aff id="af17"><label>17</label><addr-line>Epidemiology Research Program</addr-line>,<institution>American Cancer Society</institution>,<addr-line>Atlanta, GA 30303</addr-line>,<country>USA</country>,</aff><aff id="af18"><label>18</label><institution>Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) and Geriatric Research, Education, and Clinical Center (GRECC), Boston Veterans Affairs Healthcare System</institution>,<addr-line>Boston, MA 02114</addr-line>,<country>USA</country>,</aff><aff id="af19"><label>19</label><addr-line>Division of Aging, Department of Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA 02215</addr-line>,<country>USA</country>,</aff><aff id="af20"><label>20</label><addr-line>Department of Genomics of Common Disease</addr-line>,<institution>School of Public Health, Imperial College</institution>,<addr-line>London SW7 2AZ</addr-line>,<country>UK</country>,</aff><aff id="af21"><label>21</label><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>School of Public Health, Imperial College London</institution>,<country>UK</country>,</aff><aff id="af22"><label>22</label><addr-line>Lyon Cancer Research Center</addr-line>,<institution>INSERM U1052</institution>,<addr-line>Lyon</addr-line>,<country>France</country>,</aff><aff id="af23"><label>23</label><addr-line>Genomic Epidemiology Group</addr-line>,</aff><aff id="af24"><label>24</label><addr-line>Division of Clinical Epidemiology and Aging Research</addr-line> and</aff><aff id="af25"><label>25</label><addr-line>Division of Cancer Epidemiology</addr-line>,<institution>German Cancer Research Centre (DKFZ)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="af26"><label>26</label><addr-line>Division of Urologic Surgery</addr-line>,<institution>Washington University School of Medicine</institution>,<addr-line>St Louis, MO</addr-line>,<country>USA</country>,</aff><aff id="af27"><label>27</label><addr-line>Division of Epidemiology, Department of Environmental Medicine</addr-line>,<institution>NYU Langone Medical Centre, NYU Cancer Institute</institution>,<addr-line>New York, NY 10016</addr-line>,<country>USA</country>,</aff><aff id="af28"><label>28</label><institution>Institute of Biomedical Technology/BioMediTech, University of Tampere</institution> and</aff><aff id="af29"><label>29</label><addr-line>Department of Pathology, Centre for Laboratory Medicine</addr-line>,<institution>Tampere University Hospital</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</aff><aff id="af30"><label>30</label><addr-line>Department of Epidemiology</addr-line>,<institution>School of Health Sciences</institution> and</aff><aff id="af31"><label>31</label><addr-line>Department of Urology</addr-line>,<institution>Tampere University Hospital and Medical School, University of Tampere</institution>,<addr-line>Tampere</addr-line>,<country>Finland</country>,</aff><aff id="af32"><label>32</label><addr-line>Department of Medical Biochemistry and Genetics</addr-line>,<institution>University of Turku</institution>,<addr-line>Turku</addr-line>,<country>Finland</country>,</aff><aff id="af33"><label>33</label><addr-line>Department of Clinical Biochemistry</addr-line> and</aff><aff id="af34"><label>34</label><addr-line>Department of Urology</addr-line>,<institution>Herlev Hospital, Copenhagen University Hospital</institution>,<addr-line>Herlev Ringvej 75, Herlev DK-2730</addr-line>,<country>Denmark</country>,</aff><aff id="af35"><label>35</label><addr-line>Division of Public Health Sciences</addr-line>,<institution>Fred Hutchinson Cancer Research Centre</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</aff><aff id="af36"><label>36</label><addr-line>Department of Epidemiology</addr-line>,<institution>School of Public Health, University of Washington</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</aff><aff id="af37"><label>37</label><institution>National Human Genome Research Institute, National Institutes of Health</institution>,<addr-line>50 South Drive, Room 5351, Bethesda, MD</addr-line>,<country>USA</country>,</aff><aff id="af38"><label>38</label><addr-line>Department of Genetics and Pathology, International Hereditary Cancer Center</addr-line>,<institution>Pomeranian Medical University</institution>,<addr-line>Szczecin</addr-line>,<country>Poland</country>,</aff><aff id="af39"><label>39</label><institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country>,</aff><aff id="af40"><label>40</label><addr-line>Department of Molecular Medicine</addr-line> and</aff><aff id="af41"><label>41</label><addr-line>Department of Urology</addr-line>,<institution>Aarhus University Hospital</institution>,<addr-line>Skejby</addr-line>,<country>Denmark</country>,</aff><aff id="af42"><label>42</label><institution>Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation, Queensland University of Technology</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</aff><aff id="af43"><label>43</label><institution>Griffith Health Institute, Griffith University</institution>,<addr-line>Gold Coast, QLD</addr-line>,<country>Australia</country>,</aff><aff id="af44"><label>44</label><institution>Viertel Centre for Research in Cancer Control, Cancer Council Queensland</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</aff><aff id="af45"><label>45</label><institution>Centre for Clinical Research, University of Queensland</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</aff><aff id="af46"><label>46</label><addr-line>Department of Urology</addr-line> and</aff><aff id="af47"><label>47</label><institution>Institute of Human Genetics, University Hospital Ulm</institution>,<addr-line>Ulm</addr-line>,<country>Germany</country>,</aff><aff id="af48"><label>48</label><institution>Hannover Medical School</institution>,<addr-line>Hannover</addr-line>,<country>Germany</country>,</aff><aff id="af49"><label>49</label><addr-line>Department of Urology,</addr-line><institution>Akita University Graduate School of Medicine</institution>,<addr-line>1-1-1 Hondo, Akita 010-8543</addr-line>,<country>Japan</country>,</aff><aff id="af50"><label>50</label><institution>Cancer Prevention Institute of California</institution>,<addr-line>Fremont</addr-line>, CA,<country>USA</country>,</aff><aff id="af51"><label>51</label><institution>Division of Epidemiology, Department of Health Research and Policy and Stanford Cancer Institute, Stanford University School of Medicine</institution>,<addr-line>Stanford, CA</addr-line>,<country>USA</country>,</aff><aff id="af52"><label>52</label><institution>Menzies Research Institute Tasmania, University of Tasmania</institution>,<addr-line>Hobart, TAS</addr-line>,<country>Australia</country>,</aff><aff id="af53"><label>53</label><addr-line>Division of Genetic Epidemiology, Department of Internal Medicine</addr-line>,<institution>University of Utah School of Medicine</institution>,<addr-line>Salt Lake City, UT</addr-line>,<country>USA</country>,</aff><aff id="af54"><label>54</label><addr-line>George E. Wahlen Department of Veterans Affairs Medical Centre, Salt Lake City, UT</addr-line>,<country>USA</country>,</aff><aff id="af55"><label>55</label><addr-line>Department of Genetics</addr-line>,<institution>Portuguese Oncology Institute and Biomedical Sciences Institute (ICBAS), Porto University</institution>,<addr-line>Porto</addr-line>,<country>Portugal</country>,</aff><aff id="af56"><label>56</label><addr-line>Molecular Medicine Centre, Department of Medical Chemistry and Biochemistry</addr-line>,<institution>Medical University of Sofia</institution>,<addr-line>2 Zdrave St, Sofia 1431</addr-line>,<country>Bulgaria</country>,</aff><aff id="af57"><label>57</label><addr-line>Department of Epidemiology</addr-line>,<institution>Second Military Medical University</institution>,<addr-line>Shanghai</addr-line>,<country>China</country>,</aff><aff id="af58"><label>58</label><institution>Centre for Molecular Oncology and Imaging, Barts Cancer Institute, Queen Mary University of London</institution>,<addr-line>Charterhouse Square, London</addr-line>,<country>UK</country>,</aff><aff id="af59"><label>59</label><addr-line>Division of Cancer Prevention and Control</addr-line>,<institution>H. Lee Moffitt Cancer Centre</institution>,<addr-line>12902 Magnolia Drive, Tampa, FL</addr-line>,<country>USA</country>,</aff><aff id="af60"><label>60</label><addr-line>Department of Internal Medicine</addr-line> and</aff><aff id="af61"><label>61</label><addr-line>Department of Urology</addr-line>,<institution>University of Michigan Medical School</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</aff><aff id="af62"><label>62</label><institution>Warwick Medical School, University of Warwick</institution>,<addr-line>Coventry</addr-line>,<country>UK</country>,</aff><aff id="af63"><label>63</label><addr-line>Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey</addr-line>,<country>UK</country>,</aff><aff id="af64"><label>64</label><addr-line>Genetic Epidemiology Laboratory, Department of Pathology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Grattan street, Parkville, VIC</addr-line>,<country>Australia</country>,</aff><aff id="af65"><label>65</label><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>Cancer Council Victoria</institution>,<addr-line>1 Rathdowne Street, Carlton, VIC</addr-line>,<country>Australia</country>,</aff><aff id="af66"><label>66</label><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>723 Swanston Street, Carlton, VIC</addr-line>,<country>Australia</country>,</aff><aff id="af67"><label>67</label><addr-line>Department of Chronic Disease Prevention</addr-line>,<institution>National Institute for Health and Welfare</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</aff><aff id="af68"><label>68</label><addr-line>Epidemiology Program, University of Hawaii Cancer Centre, Department of Medicine, John A. Burns School of Medicine</addr-line>,<institution>University of Hawaii</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</aff><aff id="af69"><label>69</label><addr-line>Department of Oncology</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country>,</aff><aff id="af70"><label>70</label><addr-line>Division of Urology, Department of Clinical Sciences</addr-line>,<institution>Danderyd Hospital</institution> and</aff><aff id="af71"><label>71</label><institution>Oncological Centre, CLINTEC, Karolinska Institute</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</aff><aff id="af72"><label>72</label><addr-line>School of Medicine</addr-line>,<institution>Johns Hopkins University</institution>,<addr-line>115 Marburg Building, 600 North Wolfe Street, Baltimore, MD 21205</addr-line>,<country>USA</country>,</aff><aff id="af73"><label>73</label><institution>Center for Cancer Genomics, Wake Forest University School of Medicine, Medical Center Boulevard</institution>,<addr-line>Winston-Salem, NC 27157</addr-line>,<country>USA</country>,</aff><aff id="af74"><label>74</label><addr-line>Department of Urology</addr-line>,<institution>Helsinki University Central Hospital, University of Helsinki</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</aff><aff id="af75"><label>75</label><addr-line>Department of Urology</addr-line> and</aff><aff id="af76"><label>76</label><addr-line>Department of Clinical Biochemistry</addr-line>,<institution>Rigshospitalet, Copenhagen University Hospital</institution>,<addr-line>Blegdamsvej 9, Copenhagen DK-2100</addr-line>,<country>Denmark</country>,</aff><aff id="af77"><label>77</label><addr-line>Department of Urology</addr-line>,<institution>Rechts der Isar Medical Centre, Technical University of Munich</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</aff><aff id="af78"><label>78</label><addr-line>Molecular Cancer Epidemiology Laboratory</addr-line>,<institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</aff><aff id="af79"><label>79</label><institution>Huntsman Cancer Institute</institution>,<addr-line>Salt Lake City, UT</addr-line>,<country>USA</country> and</aff><aff id="af80"><label>80</label><addr-line>Department of Urology and Alexandrovska University Hospital,</addr-line><institution>Medical University of Sofia</institution>,<addr-line>Sofia</addr-line>,<country>Bulgaria</country></aff><author-notes><corresp id="cor1"><label>*</label>To whom correspondence should be addressed at: Oncogenetics Team, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK. Tel: +<phone>44 2086613642</phone>; Fax: +<fax>44 2087701489</fax>; Email: <email>rosalind.eeles@icr.ac.uk</email></corresp><fn id="AN1"><label>†</label><p>These authors jointly directed this work.</p></fn><fn id="AN2"><label>‡</label><p>These authors contributed jointly to this work.</p></fn><fn id="AN3"><label>¶</label><p>UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology—membership list provided in <ext-link ext-link-type="uri" xlink:href="http://hmg.oxfordjournals.org/lookup/suppl/doi:10.1093/hmg/dds425/-/DC1">Supplementary Material, Notes</ext-link>.</p></fn><fn id="AN4"><label>§</label><p>UK ProtecT Study Collaborators—membership list provided in <ext-link ext-link-type="uri" xlink:href="http://hmg.oxfordjournals.org/lookup/suppl/doi:10.1093/hmg/dds425/-/DC1">Supplementary Material, Notes</ext-link>.</p></fn><fn id="AN5"><label>‖</label><p>Full list of participants of The Australian Prostate Cancer BioResource is provided in <ext-link ext-link-type="uri" xlink:href="http://hmg.oxfordjournals.org/lookup/suppl/doi:10.1093/hmg/dds425/-/DC1">Supplementary Material, Notes</ext-link>.</p></fn><fn id="AN6"><label>#</label><p>Full list of participants of The PRACTICAL Consortium is provided in the <ext-link ext-link-type="uri" xlink:href="http://hmg.oxfordjournals.org/lookup/suppl/doi:10.1093/hmg/dds425/-/DC1">Supplementary Material, Notes</ext-link>.</p></fn></author-notes><pub-date pub-type="ppub"><day>15</day><month>1</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>12</day><month>10</month><year>2012</year></pub-date><volume>22</volume><issue>2</issue><fpage>408</fpage><lpage>415</lpage><history><date date-type="received"><day>20</day><month>6</month><year>2012</year></date><date date-type="accepted"><day>4</day><month>10</month><year>2012</year></date></history><permissions><copyright-statement>© The Author 2012. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="dds425.pdf"></self-uri><abstract><p>Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03–1.21), <italic>P</italic> = 1.4 × 10<sup>−8</sup>]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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