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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11</title><author><name sortKey="Siddiq, Afshan" sort="Siddiq, Afshan" uniqKey="Siddiq A" first="Afshan" last="Siddiq">Afshan Siddiq</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Department of Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Genomics of Common Disease, School of Public Health</addr-line>,<institution>Imperial College London</institution>,<addr-line>London</addr-line><country>, UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="af3"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af4"><addr-line>Department of Laboratory Medicine and Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chen, Gary K" sort="Chen, Gary K" uniqKey="Chen G" first="Gary K." last="Chen">Gary K. Chen</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><affiliation><nlm:aff wicri:cut=" and" id="af9"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name><affiliation><nlm:aff id="af11"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Millikan, Robert C" sort="Millikan, Robert C" uniqKey="Millikan R" first="Robert C." last="Millikan">Robert C. Millikan</name><affiliation><nlm:aff id="af12"><addr-line>Department of Epidemiology, Gillings School of Global Public Health, and Lineberger Comprehensive Cancer Center</addr-line>,<institution>University of North Carolina</institution>,<addr-line>Chapel Hill, NC</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff wicri:cut=" and" id="af13"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Beckmann, Lars" sort="Beckmann, Lars" uniqKey="Beckmann L" first="Lars" last="Beckmann">Lars Beckmann</name><affiliation><nlm:aff id="af15"><addr-line>Institute for Quality and Efficiency in Health Care</addr-line>,<institution>IQWiG</institution>,<addr-line>Cologne</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Rhie, Suhn Kyong" sort="Rhie, Suhn Kyong" uniqKey="Rhie S" first="Suhn Kyong" last="Rhie">Suhn Kyong Rhie</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B." last="Ambrosone">Christine B. Ambrosone</name><affiliation><nlm:aff id="af16"><addr-line>Department of Cancer Prevention and Control</addr-line>,<institution>Roswell Park Cancer Institute</institution>,<addr-line>Buffalo, NY</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff wicri:cut=" and" id="af17"><addr-line>Department of Clinical Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Amiano, Pilar" sort="Amiano, Pilar" uniqKey="Amiano P" first="Pilar" last="Amiano">Pilar Amiano</name><affiliation><nlm:aff id="af20"><institution>Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af23"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Bandera, Elisa V" sort="Bandera, Elisa V" uniqKey="Bandera E" first="Elisa V." last="Bandera">Elisa V. Bandera</name><affiliation><nlm:aff id="af26"><institution>The Cancer Institute of New Jersey</institution>,<addr-line>New Brunswick, NJ</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="af27"><addr-line>Department of Gynecology and Obstetrics</addr-line>,<institution>Friedrich-Alexander University Erlangen-Nuremberg</institution>,<institution>University Hospital Erlangen</institution>,<institution>University Breast Center Franconia</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Berg, Christine D" sort="Berg, Christine D" uniqKey="Berg C" first="Christine D." last="Berg">Christine D. Berg</name><affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Early Detection Research Group, Division of Cancer Prevention</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name><affiliation><nlm:aff id="af32"><addr-line>Division of Cancer Etiology, Department of Population Science</addr-line>,<institution>Beckman Research Institute</institution>,<addr-line>City of Hope, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="af19"><addr-line>Department of Oncology</addr-line>,<institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name><affiliation><nlm:aff id="af31"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Bui, Quang M" sort="Bui, Quang M" uniqKey="Bui Q" first="Quang M." last="Bui">Quang M. Bui</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Buring, Julie E" sort="Buring, Julie E" uniqKey="Buring J" first="Julie E." last="Buring">Julie E. Buring</name><affiliation><nlm:aff id="af35"><addr-line>Brigham and Women's Hospital and Harvard Medical School, Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name><affiliation><nlm:aff id="af37"><addr-line>Huntsman Cancer Institute</addr-line>,<institution>University of Utah</institution>,<addr-line>Salt Lake City, UT</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Campa, Daniele" sort="Campa, Daniele" uniqKey="Campa D" first="Daniele" last="Campa">Daniele Campa</name><affiliation><nlm:aff wicri:cut=" and" id="af38"><addr-line>Genomic Epidemiology Group</addr-line></nlm:aff></affiliation></author><author><name sortKey="Carpenter, Jane E" sort="Carpenter, Jane E" uniqKey="Carpenter J" first="Jane E." last="Carpenter">Jane E. Carpenter</name><affiliation><nlm:aff wicri:cut=" and" id="af24"><addr-line>Australian Breast Cancer Tissue Bank, Westmead Millennium Institute</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="af36"><addr-line>Division of Preventive Medicine</addr-line>,<institution>Brigham and Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff wicri:cut=" and" id="af39"><addr-line>Division of Cancer Epidemiology</addr-line>,<institution>German Cancer Research Center</institution></nlm:aff></affiliation></author><author><name sortKey="Chen, Constance" sort="Chen, Constance" uniqKey="Chen C" first="Constance" last="Chen">Constance Chen</name><affiliation><nlm:aff wicri:cut=" and" id="af9"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Clavel Chapelon, Francoise" sort="Clavel Chapelon, Francoise" uniqKey="Clavel Chapelon F" first="Françoise" last="Clavel-Chapelon">Françoise Clavel-Chapelon</name><affiliation><nlm:aff id="af41"><addr-line>INSERM UMR 1018, Team 9: Nutrition, Hormones et Santé desfemmes, Centre de Recherche en Epidémiologie et Santé des Populations</addr-line>,<institution>Hôpital Paul Brousse</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff wicri:cut=" and" id="af42"><addr-line>Institute for Cancer Studies, Department of Oncology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="af43"><addr-line>Academic Unit of Pathology, Department of Neuroscience, Faculty of Medicine, Dentistry and Health</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="af44"><addr-line>Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Deming, Sandra L" sort="Deming, Sandra L" uniqKey="Deming S" first="Sandra L." last="Deming">Sandra L. Deming</name><affiliation><nlm:aff id="af45"><addr-line>Division of Epidemiology, Department of Medicine</addr-line>,<institution>Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Diasio, Robert B" sort="Diasio, Robert B" uniqKey="Diasio R" first="Robert B." last="Diasio">Robert B. Diasio</name><affiliation><nlm:aff id="af5"><addr-line>Department of Pharmacology</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name><affiliation><nlm:aff id="af46"><addr-line>Epidemiology Research Program</addr-line>,<institution>American Cancer Society</institution>,<addr-line>Atlanta, GA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="af14"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Durcan, Lorraine" sort="Durcan, Lorraine" uniqKey="Durcan L" first="Lorraine" last="Durcan">Lorraine Durcan</name><affiliation><nlm:aff id="af11"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="af47"><institution>Friedrich-Alexander University Erlangen-Nuremberg, Institute of Human Genetics</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="af27"><addr-line>Department of Gynecology and Obstetrics</addr-line>,<institution>Friedrich-Alexander University Erlangen-Nuremberg</institution>,<institution>University Hospital Erlangen</institution>,<institution>University Breast Center Franconia</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af48"><addr-line>David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology</addr-line>,<institution>University of California at Los Angeles</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Feigelson, Heather Spencer" sort="Feigelson, Heather Spencer" uniqKey="Feigelson H" first="Heather Spencer" last="Feigelson">Heather Spencer Feigelson</name><affiliation><nlm:aff id="af51"><addr-line>Institute for Health Research</addr-line>,<institution>Kaiser Permanente</institution>,<addr-line>Denver, CO</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Fejerman, Laura" sort="Fejerman, Laura" uniqKey="Fejerman L" first="Laura" last="Fejerman">Laura Fejerman</name><affiliation><nlm:aff id="af52"><addr-line>Division of General Internal Medicine, Department of Medicine, Institute for Human Genetics and Helen Diller Family Comprehensive Cancer Center</addr-line>,<institution>University of California</institution>,<addr-line>San Francisco, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:aff id="af31"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="af53"><addr-line>Institute of Cancer Research</addr-line>,<institution>Breakthrough Breast Cancer Research Centre</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="af54"><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry</addr-line>,<institution>University Cancer Center Hamburg (UCCH)</institution> ,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af55"><addr-line>Department of Medical Biometrics and Epidemiology</addr-line>,<institution>University Medical Center Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="af46"><addr-line>Epidemiology Research Program</addr-line>,<institution>American Cancer Society</institution>,<addr-line>Atlanta, GA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Gerty, Susan M" sort="Gerty, Susan M" uniqKey="Gerty S" first="Susan M." last="Gerty">Susan M. Gerty</name><affiliation><nlm:aff id="af11"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Rodriguez Gil, Jorge L" sort="Rodriguez Gil, Jorge L" uniqKey="Rodriguez Gil J" first="Jorge L." last="Rodriguez-Gil">Jorge L. Rodriguez-Gil</name><affiliation><nlm:aff id="af60"><addr-line>Sylvester Comprehensive Cancer Center and Department of Epidemiology and Public Health</addr-line>,<institution>University of Miami Miller School of Medicine</institution>,<addr-line>Miami, FL</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af23"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Van Gils, Carla H" sort="Van Gils, Carla H" uniqKey="Van Gils C" first="Carla H." last="Van Gils">Carla H. Van Gils</name><affiliation><nlm:aff id="af61"><institution>Julius Center, University Medical Center</institution>,<addr-line>Utrecht</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="af62"><addr-line>Department of Pathology and Laboratory Medicine</addr-line>,<institution>Kansas University Medical Center</institution>,<addr-line>Kansas City, KS</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Graham, Nikki" sort="Graham, Nikki" uniqKey="Graham N" first="Nikki" last="Graham">Nikki Graham</name><affiliation><nlm:aff id="af11"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Greco, Dario" sort="Greco, Dario" uniqKey="Greco D" first="Dario" last="Greco">Dario Greco</name><affiliation><nlm:aff wicri:cut=" and" id="af18"><addr-line>Department of Obstetrics and Gynecology</addr-line>,<institution>University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="af44"><addr-line>Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name><affiliation><nlm:aff id="af35"><addr-line>Brigham and Women's Hospital and Harvard Medical School, Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hartmann, Arndt" sort="Hartmann, Arndt" uniqKey="Hartmann A" first="Arndt" last="Hartmann">Arndt Hartmann</name><affiliation><nlm:aff wicri:cut=" and" id="af28"><addr-line>Institute of Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation><nlm:aff wicri:cut=" and" id="af39"><addr-line>Division of Cancer Epidemiology</addr-line>,<institution>German Cancer Research Center</institution></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af63"><addr-line>PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Heinz, Judith" sort="Heinz, Judith" uniqKey="Heinz J" first="Judith" last="Heinz">Judith Heinz</name><affiliation><nlm:aff id="af54"><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry</addr-line>,<institution>University Cancer Center Hamburg (UCCH)</institution> ,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af55"><addr-line>Department of Medical Biometrics and Epidemiology</addr-line>,<institution>University Medical Center Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N." last="Hoover">Robert N. Hoover</name><affiliation><nlm:aff id="af31"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hu, Jennifer J" sort="Hu, Jennifer J" uniqKey="Hu J" first="Jennifer J." last="Hu">Jennifer J. Hu</name><affiliation><nlm:aff id="af60"><addr-line>Sylvester Comprehensive Cancer Center and Department of Epidemiology and Public Health</addr-line>,<institution>University of Miami Miller School of Medicine</institution>,<addr-line>Miami, FL</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Huntsman, Scott" sort="Huntsman, Scott" uniqKey="Huntsman S" first="Scott" last="Huntsman">Scott Huntsman</name><affiliation><nlm:aff id="af51"><addr-line>Institute for Health Research</addr-line>,<institution>Kaiser Permanente</institution>,<addr-line>Denver, CO</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ingles, Sue A" sort="Ingles, Sue A" uniqKey="Ingles S" first="Sue A." last="Ingles">Sue A. Ingles</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation><nlm:aff id="af65"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><affiliation><nlm:aff id="af66"><addr-line>Lombardi Comprehensive Cancer Center</addr-line>,<institution>Georgetown University</institution>,<addr-line>Washington, DC</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Jacobs, Kevin B" sort="Jacobs, Kevin B" uniqKey="Jacobs K" first="Kevin B." last="Jacobs">Kevin B. Jacobs</name><affiliation><nlm:aff id="af31"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af67"><addr-line>Core Genotyping Facility</addr-line>,<institution>SAIC-Frederick Inc., NCI-Frederick</institution>,<addr-line>Frederick, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af68"><institution>Bioinformed Consulting Services</institution>,<addr-line>Gaithersburg, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="af69"><addr-line>Cancer Prevention Institute of California, Fremont, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af70"><addr-line>Stanford University School of Medicine</addr-line>,<institution>Stanford Cancer Institute</institution>,<addr-line>Stanford, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:aff wicri:cut=" and" id="af39"><addr-line>Division of Cancer Epidemiology</addr-line>,<institution>German Cancer Research Center</institution></nlm:aff></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><affiliation><nlm:aff id="af71"><addr-line>Epidemiology Program</addr-line>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Coetzee, Gerhard A" sort="Coetzee, Gerhard A" uniqKey="Coetzee G" first="Gerhard A." last="Coetzee">Gerhard A. Coetzee</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af8"><addr-line>Department of Urology</addr-line>,<institution>Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA 90089</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:aff id="af72"><institution>Centre National de Genotypage</institution>,<addr-line>Evry</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af73"><institution>Fondation Jean Dausset, CEPH</institution>,<addr-line>Paris</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="af71"><addr-line>Epidemiology Program</addr-line>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lee, Adam M" sort="Lee, Adam M" uniqKey="Lee A" first="Adam M." last="Lee">Adam M. Lee</name><affiliation><nlm:aff id="af5"><addr-line>Department of Pharmacology</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lee, I Min" sort="Lee, I Min" uniqKey="Lee I" first="I-Min" last="Lee">I-Min Lee</name><affiliation><nlm:aff id="af35"><addr-line>Brigham and Women's Hospital and Harvard Medical School, Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lesnick, Timothy" sort="Lesnick, Timothy" uniqKey="Lesnick T" first="Timothy" last="Lesnick">Timothy Lesnick</name><affiliation><nlm:aff id="af3"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation><nlm:aff id="af74"><addr-line>Institute of Human Genetics</addr-line>,<institution>Helmholtz Zentrum München, German Research Center for Environmental Health</institution>,<addr-line>Neuherberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="af65"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff></affiliation></author><author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name><affiliation><nlm:aff id="af75"><addr-line>Institute of Community Medicine</addr-line>,<institution>University of Tromsø</institution>,<addr-line>Tromsø</addr-line>,<country>Norway</country>,</nlm:aff></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="af76"><addr-line>QIMR GWAS Collective</addr-line>,<institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona A" sort="Mclean, Catriona A" uniqKey="Mclean C" first="Catriona A." last="Mclean">Catriona A. Mclean</name><affiliation><nlm:aff id="af77"><institution>The Alfred Hospital</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><affiliation><nlm:aff id="af78"><addr-line>Department of Clinical Genetics</addr-line>,<institution>VU University Medical Center, section Oncogenetics</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="af79"><addr-line>Clinic of Gynaecology and Obstetrics, Division for Gynaecological Tumor-Genetics</addr-line>,<institution>Technische Universität München</institution>,<addr-line>München</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Miron, Penelope" sort="Miron, Penelope" uniqKey="Miron P" first="Penelope" last="Miron">Penelope Miron</name><affiliation><nlm:aff id="af80"><institution>Dana Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Monroe, Kristine R" sort="Monroe, Kristine R" uniqKey="Monroe K" first="Kristine R." last="Monroe">Kristine R. Monroe</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="af76"><addr-line>QIMR GWAS Collective</addr-line>,<institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation><nlm:aff id="af81"><institution>Max Planck Institute of Psychiatry</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Nickels, Stefan" sort="Nickels, Stefan" uniqKey="Nickels S" first="Stefan" last="Nickels">Stefan Nickels</name><affiliation><nlm:aff wicri:cut=" and" id="af39"><addr-line>Division of Cancer Epidemiology</addr-line>,<institution>German Cancer Research Center</institution></nlm:aff></affiliation></author><author><name sortKey="Nyante, Sarah J" sort="Nyante, Sarah J" uniqKey="Nyante S" first="Sarah J." last="Nyante">Sarah J. Nyante</name><affiliation><nlm:aff id="af31"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Olswold, Curtis" sort="Olswold, Curtis" uniqKey="Olswold C" first="Curtis" last="Olswold">Curtis Olswold</name><affiliation><nlm:aff id="af3"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation><nlm:aff id="af82"><addr-line>Department of Cardiology, Center for Cardiovascular Research</addr-line>,<institution>Aalborg Hospital</institution>,<institution>Aarhus University Hospital</institution>,<addr-line>Aalborg</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><affiliation><nlm:aff id="af83"><addr-line>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute</addr-line>,<institution>ISPO</institution>,<addr-line>Florence</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J." last="Park">Daniel J. Park</name><affiliation><nlm:aff id="af22"><addr-line>Genetic Epidemiology Laboratory, Department of Pathology</addr-line>,<institution>The University of Melbourne</institution>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Palmer, Julie R" sort="Palmer, Julie R" uniqKey="Palmer J" first="Julie R." last="Palmer">Julie R. Palmer</name><affiliation><nlm:aff id="af84"><institution>Slone Epidemiology Center at Boston University</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Pathak, Harsh" sort="Pathak, Harsh" uniqKey="Pathak H" first="Harsh" last="Pathak">Harsh Pathak</name><affiliation><nlm:aff id="af62"><addr-line>Department of Pathology and Laboratory Medicine</addr-line>,<institution>Kansas University Medical Center</institution>,<addr-line>Kansas City, KS</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="af85"><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul" sort="Pharoah, Paul" uniqKey="Pharoah P" first="Paul" last="Pharoah">Paul Pharoah</name><affiliation><nlm:aff id="af14"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation><nlm:aff wicri:cut=" and" id="af49"><addr-line>Section of Cancer Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="af86"><addr-line>Department of Internal Medicine and Epidemiology</addr-line>,<institution>Erasmus Medical Center</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F." last="Schmidt">Daniel F. Schmidt</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="af64"><addr-line>Division of Molecular Gynaeco-Oncology, Department of Obstetrics and Gynaecology</addr-line>,<institution>University of Cologne</institution>,<addr-line>Cologne</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation><nlm:aff id="af3"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="af22"><addr-line>Genetic Epidemiology Laboratory, Department of Pathology</addr-line>,<institution>The University of Melbourne</institution>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Stevens, Kristen N" sort="Stevens, Kristen N" uniqKey="Stevens K" first="Kristen N." last="Stevens">Kristen N. Stevens</name><affiliation><nlm:aff id="af3"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Sinn, Hans Peter" sort="Sinn, Hans Peter" uniqKey="Sinn H" first="Hans-Peter" last="Sinn">Hans-Peter Sinn</name><affiliation><nlm:aff id="af87"><addr-line>Department of Pathology</addr-line>,<institution>University Hospital Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Press, Michael F" sort="Press, Michael F" uniqKey="Press M" first="Michael F." last="Press">Michael F. Press</name><affiliation><nlm:aff id="af7"><addr-line>Department of Pathology</addr-line>,<institution>Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ross, Eric" sort="Ross, Eric" uniqKey="Ross E" first="Eric" last="Ross">Eric Ross</name><affiliation><nlm:aff wicri:cut=" and" id="af88"><addr-line>Department of Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Department of Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="af36"><addr-line>Division of Preventive Medicine</addr-line>,<institution>Brigham and Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af23"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos Santos Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="af85"><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name><affiliation><nlm:aff wicri:cut=" and" id="af90"><addr-line>Department of Surgery</addr-line>,<institution>Umeå University</institution>,<addr-line>Umea</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Tapper, William J" sort="Tapper, William J" uniqKey="Tapper W" first="William J." last="Tapper">William J. Tapper</name><affiliation><nlm:aff id="af11"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Thun, Michael J" sort="Thun, Michael J" uniqKey="Thun M" first="Michael J." last="Thun">Michael J. Thun</name><affiliation><nlm:aff id="af46"><addr-line>Epidemiology Research Program</addr-line>,<institution>American Cancer Society</institution>,<addr-line>Atlanta, GA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="af91"><addr-line>Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation><nlm:aff wicri:cut=" and" id="af49"><addr-line>Section of Cancer Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="af86"><addr-line>Department of Internal Medicine and Epidemiology</addr-line>,<institution>Erasmus Medical Center</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Waisfisz, Quinten" sort="Waisfisz, Quinten" uniqKey="Waisfisz Q" first="Quinten" last="Waisfisz">Quinten Waisfisz</name><affiliation><nlm:aff id="af78"><addr-line>Department of Clinical Genetics</addr-line>,<institution>VU University Medical Center, section Oncogenetics</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff wicri:cut=" and" id="af4"><addr-line>Department of Laboratory Medicine and Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation><nlm:aff id="af31"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af67"><addr-line>Core Genotyping Facility</addr-line>,<institution>SAIC-Frederick Inc., NCI-Frederick</institution>,<addr-line>Frederick, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Weaver, Joellen" sort="Weaver, Joellen" uniqKey="Weaver J" first="Joellen" last="Weaver">Joellen Weaver</name><affiliation><nlm:aff id="af89"><addr-line>Biosample Repository</addr-line>,<institution>Fox Chase Cancer Center</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Schulz Wendtland, Rudiger" sort="Schulz Wendtland, Rudiger" uniqKey="Schulz Wendtland R" first="Rüdiger" last="Schulz-Wendtland">Rüdiger Schulz-Wendtland</name><affiliation><nlm:aff id="af29"><addr-line>Institute of Diagnostic Radiology</addr-line>,<institution>Friedrich-Alexander University Erlangen-Nuremberg</institution>,<institution>University Hospital Erlangen</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Wilkens, Lynne R" sort="Wilkens, Lynne R" uniqKey="Wilkens L" first="Lynne R." last="Wilkens">Lynne R. Wilkens</name><affiliation><nlm:aff id="af71"><addr-line>Epidemiology Program</addr-line>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, David" sort="Van Den Berg, David" uniqKey="Van Den Berg D" first="David" last="Van Den Berg">David Van Den Berg</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="af45"><addr-line>Division of Epidemiology, Department of Medicine</addr-line>,<institution>Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G." last="Ziegler">Regina G. Ziegler</name><affiliation><nlm:aff id="af31"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ziv, Elad" sort="Ziv, Elad" uniqKey="Ziv E" first="Elad" last="Ziv">Elad Ziv</name><affiliation><nlm:aff id="af52"><addr-line>Division of General Internal Medicine, Department of Medicine, Institute for Human Genetics and Helen Diller Family Comprehensive Cancer Center</addr-line>,<institution>University of California</institution>,<addr-line>San Francisco, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff wicri:cut=" and" id="af18"><addr-line>Department of Obstetrics and Gynecology</addr-line>,<institution>University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="af14"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff wicri:cut=" and" id="af9"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af10"><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="af31"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation><nlm:aff id="af50"><addr-line>Section of Epidemiology and Genetics</addr-line>,<institution>Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff wicri:cut=" and" id="af9"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine M" sort="Vachon, Celine M" uniqKey="Vachon C" first="Celine M." last="Vachon">Celine M. Vachon</name><affiliation><nlm:aff id="af3"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22976474</idno><idno type="pmc">3510753</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510753</idno><idno type="RBID">PMC:3510753</idno><idno type="doi">10.1093/hmg/dds381</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001868</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001868</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11</title><author><name sortKey="Siddiq, Afshan" sort="Siddiq, Afshan" uniqKey="Siddiq A" first="Afshan" last="Siddiq">Afshan Siddiq</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Department of Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Genomics of Common Disease, School of Public Health</addr-line>,<institution>Imperial College London</institution>,<addr-line>London</addr-line><country>, UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="af3"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af4"><addr-line>Department of Laboratory Medicine and Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chen, Gary K" sort="Chen, Gary K" uniqKey="Chen G" first="Gary K." last="Chen">Gary K. Chen</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><affiliation><nlm:aff wicri:cut=" and" id="af9"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name><affiliation><nlm:aff id="af11"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Millikan, Robert C" sort="Millikan, Robert C" uniqKey="Millikan R" first="Robert C." last="Millikan">Robert C. Millikan</name><affiliation><nlm:aff id="af12"><addr-line>Department of Epidemiology, Gillings School of Global Public Health, and Lineberger Comprehensive Cancer Center</addr-line>,<institution>University of North Carolina</institution>,<addr-line>Chapel Hill, NC</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff wicri:cut=" and" id="af13"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Beckmann, Lars" sort="Beckmann, Lars" uniqKey="Beckmann L" first="Lars" last="Beckmann">Lars Beckmann</name><affiliation><nlm:aff id="af15"><addr-line>Institute for Quality and Efficiency in Health Care</addr-line>,<institution>IQWiG</institution>,<addr-line>Cologne</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Rhie, Suhn Kyong" sort="Rhie, Suhn Kyong" uniqKey="Rhie S" first="Suhn Kyong" last="Rhie">Suhn Kyong Rhie</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B." last="Ambrosone">Christine B. Ambrosone</name><affiliation><nlm:aff id="af16"><addr-line>Department of Cancer Prevention and Control</addr-line>,<institution>Roswell Park Cancer Institute</institution>,<addr-line>Buffalo, NY</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff wicri:cut=" and" id="af17"><addr-line>Department of Clinical Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Amiano, Pilar" sort="Amiano, Pilar" uniqKey="Amiano P" first="Pilar" last="Amiano">Pilar Amiano</name><affiliation><nlm:aff id="af20"><institution>Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af23"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Bandera, Elisa V" sort="Bandera, Elisa V" uniqKey="Bandera E" first="Elisa V." last="Bandera">Elisa V. Bandera</name><affiliation><nlm:aff id="af26"><institution>The Cancer Institute of New Jersey</institution>,<addr-line>New Brunswick, NJ</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="af27"><addr-line>Department of Gynecology and Obstetrics</addr-line>,<institution>Friedrich-Alexander University Erlangen-Nuremberg</institution>,<institution>University Hospital Erlangen</institution>,<institution>University Breast Center Franconia</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Berg, Christine D" sort="Berg, Christine D" uniqKey="Berg C" first="Christine D." last="Berg">Christine D. Berg</name><affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Early Detection Research Group, Division of Cancer Prevention</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name><affiliation><nlm:aff id="af32"><addr-line>Division of Cancer Etiology, Department of Population Science</addr-line>,<institution>Beckman Research Institute</institution>,<addr-line>City of Hope, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="af19"><addr-line>Department of Oncology</addr-line>,<institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name><affiliation><nlm:aff id="af31"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Bui, Quang M" sort="Bui, Quang M" uniqKey="Bui Q" first="Quang M." last="Bui">Quang M. Bui</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Buring, Julie E" sort="Buring, Julie E" uniqKey="Buring J" first="Julie E." last="Buring">Julie E. Buring</name><affiliation><nlm:aff id="af35"><addr-line>Brigham and Women's Hospital and Harvard Medical School, Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name><affiliation><nlm:aff id="af37"><addr-line>Huntsman Cancer Institute</addr-line>,<institution>University of Utah</institution>,<addr-line>Salt Lake City, UT</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Campa, Daniele" sort="Campa, Daniele" uniqKey="Campa D" first="Daniele" last="Campa">Daniele Campa</name><affiliation><nlm:aff wicri:cut=" and" id="af38"><addr-line>Genomic Epidemiology Group</addr-line></nlm:aff></affiliation></author><author><name sortKey="Carpenter, Jane E" sort="Carpenter, Jane E" uniqKey="Carpenter J" first="Jane E." last="Carpenter">Jane E. Carpenter</name><affiliation><nlm:aff wicri:cut=" and" id="af24"><addr-line>Australian Breast Cancer Tissue Bank, Westmead Millennium Institute</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="af36"><addr-line>Division of Preventive Medicine</addr-line>,<institution>Brigham and Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff wicri:cut=" and" id="af39"><addr-line>Division of Cancer Epidemiology</addr-line>,<institution>German Cancer Research Center</institution></nlm:aff></affiliation></author><author><name sortKey="Chen, Constance" sort="Chen, Constance" uniqKey="Chen C" first="Constance" last="Chen">Constance Chen</name><affiliation><nlm:aff wicri:cut=" and" id="af9"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Clavel Chapelon, Francoise" sort="Clavel Chapelon, Francoise" uniqKey="Clavel Chapelon F" first="Françoise" last="Clavel-Chapelon">Françoise Clavel-Chapelon</name><affiliation><nlm:aff id="af41"><addr-line>INSERM UMR 1018, Team 9: Nutrition, Hormones et Santé desfemmes, Centre de Recherche en Epidémiologie et Santé des Populations</addr-line>,<institution>Hôpital Paul Brousse</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff wicri:cut=" and" id="af42"><addr-line>Institute for Cancer Studies, Department of Oncology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="af43"><addr-line>Academic Unit of Pathology, Department of Neuroscience, Faculty of Medicine, Dentistry and Health</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="af44"><addr-line>Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Deming, Sandra L" sort="Deming, Sandra L" uniqKey="Deming S" first="Sandra L." last="Deming">Sandra L. Deming</name><affiliation><nlm:aff id="af45"><addr-line>Division of Epidemiology, Department of Medicine</addr-line>,<institution>Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Diasio, Robert B" sort="Diasio, Robert B" uniqKey="Diasio R" first="Robert B." last="Diasio">Robert B. Diasio</name><affiliation><nlm:aff id="af5"><addr-line>Department of Pharmacology</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name><affiliation><nlm:aff id="af46"><addr-line>Epidemiology Research Program</addr-line>,<institution>American Cancer Society</institution>,<addr-line>Atlanta, GA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="af14"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Durcan, Lorraine" sort="Durcan, Lorraine" uniqKey="Durcan L" first="Lorraine" last="Durcan">Lorraine Durcan</name><affiliation><nlm:aff id="af11"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="af47"><institution>Friedrich-Alexander University Erlangen-Nuremberg, Institute of Human Genetics</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="af27"><addr-line>Department of Gynecology and Obstetrics</addr-line>,<institution>Friedrich-Alexander University Erlangen-Nuremberg</institution>,<institution>University Hospital Erlangen</institution>,<institution>University Breast Center Franconia</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af48"><addr-line>David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology</addr-line>,<institution>University of California at Los Angeles</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Feigelson, Heather Spencer" sort="Feigelson, Heather Spencer" uniqKey="Feigelson H" first="Heather Spencer" last="Feigelson">Heather Spencer Feigelson</name><affiliation><nlm:aff id="af51"><addr-line>Institute for Health Research</addr-line>,<institution>Kaiser Permanente</institution>,<addr-line>Denver, CO</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Fejerman, Laura" sort="Fejerman, Laura" uniqKey="Fejerman L" first="Laura" last="Fejerman">Laura Fejerman</name><affiliation><nlm:aff id="af52"><addr-line>Division of General Internal Medicine, Department of Medicine, Institute for Human Genetics and Helen Diller Family Comprehensive Cancer Center</addr-line>,<institution>University of California</institution>,<addr-line>San Francisco, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:aff id="af31"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="af53"><addr-line>Institute of Cancer Research</addr-line>,<institution>Breakthrough Breast Cancer Research Centre</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="af54"><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry</addr-line>,<institution>University Cancer Center Hamburg (UCCH)</institution> ,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af55"><addr-line>Department of Medical Biometrics and Epidemiology</addr-line>,<institution>University Medical Center Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="af46"><addr-line>Epidemiology Research Program</addr-line>,<institution>American Cancer Society</institution>,<addr-line>Atlanta, GA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Gerty, Susan M" sort="Gerty, Susan M" uniqKey="Gerty S" first="Susan M." last="Gerty">Susan M. Gerty</name><affiliation><nlm:aff id="af11"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Rodriguez Gil, Jorge L" sort="Rodriguez Gil, Jorge L" uniqKey="Rodriguez Gil J" first="Jorge L." last="Rodriguez-Gil">Jorge L. Rodriguez-Gil</name><affiliation><nlm:aff id="af60"><addr-line>Sylvester Comprehensive Cancer Center and Department of Epidemiology and Public Health</addr-line>,<institution>University of Miami Miller School of Medicine</institution>,<addr-line>Miami, FL</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af23"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Van Gils, Carla H" sort="Van Gils, Carla H" uniqKey="Van Gils C" first="Carla H." last="Van Gils">Carla H. Van Gils</name><affiliation><nlm:aff id="af61"><institution>Julius Center, University Medical Center</institution>,<addr-line>Utrecht</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="af62"><addr-line>Department of Pathology and Laboratory Medicine</addr-line>,<institution>Kansas University Medical Center</institution>,<addr-line>Kansas City, KS</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Graham, Nikki" sort="Graham, Nikki" uniqKey="Graham N" first="Nikki" last="Graham">Nikki Graham</name><affiliation><nlm:aff id="af11"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Greco, Dario" sort="Greco, Dario" uniqKey="Greco D" first="Dario" last="Greco">Dario Greco</name><affiliation><nlm:aff wicri:cut=" and" id="af18"><addr-line>Department of Obstetrics and Gynecology</addr-line>,<institution>University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="af44"><addr-line>Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name><affiliation><nlm:aff id="af35"><addr-line>Brigham and Women's Hospital and Harvard Medical School, Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hartmann, Arndt" sort="Hartmann, Arndt" uniqKey="Hartmann A" first="Arndt" last="Hartmann">Arndt Hartmann</name><affiliation><nlm:aff wicri:cut=" and" id="af28"><addr-line>Institute of Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation><nlm:aff wicri:cut=" and" id="af39"><addr-line>Division of Cancer Epidemiology</addr-line>,<institution>German Cancer Research Center</institution></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af63"><addr-line>PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Heinz, Judith" sort="Heinz, Judith" uniqKey="Heinz J" first="Judith" last="Heinz">Judith Heinz</name><affiliation><nlm:aff id="af54"><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry</addr-line>,<institution>University Cancer Center Hamburg (UCCH)</institution> ,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af55"><addr-line>Department of Medical Biometrics and Epidemiology</addr-line>,<institution>University Medical Center Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N." last="Hoover">Robert N. Hoover</name><affiliation><nlm:aff id="af31"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hu, Jennifer J" sort="Hu, Jennifer J" uniqKey="Hu J" first="Jennifer J." last="Hu">Jennifer J. Hu</name><affiliation><nlm:aff id="af60"><addr-line>Sylvester Comprehensive Cancer Center and Department of Epidemiology and Public Health</addr-line>,<institution>University of Miami Miller School of Medicine</institution>,<addr-line>Miami, FL</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Huntsman, Scott" sort="Huntsman, Scott" uniqKey="Huntsman S" first="Scott" last="Huntsman">Scott Huntsman</name><affiliation><nlm:aff id="af51"><addr-line>Institute for Health Research</addr-line>,<institution>Kaiser Permanente</institution>,<addr-line>Denver, CO</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ingles, Sue A" sort="Ingles, Sue A" uniqKey="Ingles S" first="Sue A." last="Ingles">Sue A. Ingles</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation><nlm:aff id="af65"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><affiliation><nlm:aff id="af66"><addr-line>Lombardi Comprehensive Cancer Center</addr-line>,<institution>Georgetown University</institution>,<addr-line>Washington, DC</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Jacobs, Kevin B" sort="Jacobs, Kevin B" uniqKey="Jacobs K" first="Kevin B." last="Jacobs">Kevin B. Jacobs</name><affiliation><nlm:aff id="af31"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af67"><addr-line>Core Genotyping Facility</addr-line>,<institution>SAIC-Frederick Inc., NCI-Frederick</institution>,<addr-line>Frederick, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af68"><institution>Bioinformed Consulting Services</institution>,<addr-line>Gaithersburg, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="af69"><addr-line>Cancer Prevention Institute of California, Fremont, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af70"><addr-line>Stanford University School of Medicine</addr-line>,<institution>Stanford Cancer Institute</institution>,<addr-line>Stanford, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name><affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:aff wicri:cut=" and" id="af39"><addr-line>Division of Cancer Epidemiology</addr-line>,<institution>German Cancer Research Center</institution></nlm:aff></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><affiliation><nlm:aff id="af71"><addr-line>Epidemiology Program</addr-line>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Coetzee, Gerhard A" sort="Coetzee, Gerhard A" uniqKey="Coetzee G" first="Gerhard A." last="Coetzee">Gerhard A. Coetzee</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af8"><addr-line>Department of Urology</addr-line>,<institution>Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA 90089</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:aff id="af72"><institution>Centre National de Genotypage</institution>,<addr-line>Evry</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af73"><institution>Fondation Jean Dausset, CEPH</institution>,<addr-line>Paris</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="af71"><addr-line>Epidemiology Program</addr-line>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lee, Adam M" sort="Lee, Adam M" uniqKey="Lee A" first="Adam M." last="Lee">Adam M. Lee</name><affiliation><nlm:aff id="af5"><addr-line>Department of Pharmacology</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lee, I Min" sort="Lee, I Min" uniqKey="Lee I" first="I-Min" last="Lee">I-Min Lee</name><affiliation><nlm:aff id="af35"><addr-line>Brigham and Women's Hospital and Harvard Medical School, Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lesnick, Timothy" sort="Lesnick, Timothy" uniqKey="Lesnick T" first="Timothy" last="Lesnick">Timothy Lesnick</name><affiliation><nlm:aff id="af3"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation><nlm:aff id="af74"><addr-line>Institute of Human Genetics</addr-line>,<institution>Helmholtz Zentrum München, German Research Center for Environmental Health</institution>,<addr-line>Neuherberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="af65"><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff></affiliation></author><author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name><affiliation><nlm:aff id="af75"><addr-line>Institute of Community Medicine</addr-line>,<institution>University of Tromsø</institution>,<addr-line>Tromsø</addr-line>,<country>Norway</country>,</nlm:aff></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="af76"><addr-line>QIMR GWAS Collective</addr-line>,<institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona A" sort="Mclean, Catriona A" uniqKey="Mclean C" first="Catriona A." last="Mclean">Catriona A. Mclean</name><affiliation><nlm:aff id="af77"><institution>The Alfred Hospital</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><affiliation><nlm:aff id="af78"><addr-line>Department of Clinical Genetics</addr-line>,<institution>VU University Medical Center, section Oncogenetics</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="af79"><addr-line>Clinic of Gynaecology and Obstetrics, Division for Gynaecological Tumor-Genetics</addr-line>,<institution>Technische Universität München</institution>,<addr-line>München</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Miron, Penelope" sort="Miron, Penelope" uniqKey="Miron P" first="Penelope" last="Miron">Penelope Miron</name><affiliation><nlm:aff id="af80"><institution>Dana Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Monroe, Kristine R" sort="Monroe, Kristine R" uniqKey="Monroe K" first="Kristine R." last="Monroe">Kristine R. Monroe</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="af76"><addr-line>QIMR GWAS Collective</addr-line>,<institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation><nlm:aff id="af81"><institution>Max Planck Institute of Psychiatry</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Nickels, Stefan" sort="Nickels, Stefan" uniqKey="Nickels S" first="Stefan" last="Nickels">Stefan Nickels</name><affiliation><nlm:aff wicri:cut=" and" id="af39"><addr-line>Division of Cancer Epidemiology</addr-line>,<institution>German Cancer Research Center</institution></nlm:aff></affiliation></author><author><name sortKey="Nyante, Sarah J" sort="Nyante, Sarah J" uniqKey="Nyante S" first="Sarah J." last="Nyante">Sarah J. Nyante</name><affiliation><nlm:aff id="af31"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Olswold, Curtis" sort="Olswold, Curtis" uniqKey="Olswold C" first="Curtis" last="Olswold">Curtis Olswold</name><affiliation><nlm:aff id="af3"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation><nlm:aff id="af82"><addr-line>Department of Cardiology, Center for Cardiovascular Research</addr-line>,<institution>Aalborg Hospital</institution>,<institution>Aarhus University Hospital</institution>,<addr-line>Aalborg</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><affiliation><nlm:aff id="af83"><addr-line>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute</addr-line>,<institution>ISPO</institution>,<addr-line>Florence</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J." last="Park">Daniel J. Park</name><affiliation><nlm:aff id="af22"><addr-line>Genetic Epidemiology Laboratory, Department of Pathology</addr-line>,<institution>The University of Melbourne</institution>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Palmer, Julie R" sort="Palmer, Julie R" uniqKey="Palmer J" first="Julie R." last="Palmer">Julie R. Palmer</name><affiliation><nlm:aff id="af84"><institution>Slone Epidemiology Center at Boston University</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Pathak, Harsh" sort="Pathak, Harsh" uniqKey="Pathak H" first="Harsh" last="Pathak">Harsh Pathak</name><affiliation><nlm:aff id="af62"><addr-line>Department of Pathology and Laboratory Medicine</addr-line>,<institution>Kansas University Medical Center</institution>,<addr-line>Kansas City, KS</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="af85"><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul" sort="Pharoah, Paul" uniqKey="Pharoah P" first="Paul" last="Pharoah">Paul Pharoah</name><affiliation><nlm:aff id="af14"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation><nlm:aff wicri:cut=" and" id="af49"><addr-line>Section of Cancer Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:aff id="af86"><addr-line>Department of Internal Medicine and Epidemiology</addr-line>,<institution>Erasmus Medical Center</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F." last="Schmidt">Daniel F. Schmidt</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="af64"><addr-line>Division of Molecular Gynaeco-Oncology, Department of Obstetrics and Gynaecology</addr-line>,<institution>University of Cologne</institution>,<addr-line>Cologne</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation><nlm:aff id="af3"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="af22"><addr-line>Genetic Epidemiology Laboratory, Department of Pathology</addr-line>,<institution>The University of Melbourne</institution>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Stevens, Kristen N" sort="Stevens, Kristen N" uniqKey="Stevens K" first="Kristen N." last="Stevens">Kristen N. Stevens</name><affiliation><nlm:aff id="af3"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Sinn, Hans Peter" sort="Sinn, Hans Peter" uniqKey="Sinn H" first="Hans-Peter" last="Sinn">Hans-Peter Sinn</name><affiliation><nlm:aff id="af87"><addr-line>Department of Pathology</addr-line>,<institution>University Hospital Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Press, Michael F" sort="Press, Michael F" uniqKey="Press M" first="Michael F." last="Press">Michael F. Press</name><affiliation><nlm:aff id="af7"><addr-line>Department of Pathology</addr-line>,<institution>Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ross, Eric" sort="Ross, Eric" uniqKey="Ross E" first="Eric" last="Ross">Eric Ross</name><affiliation><nlm:aff wicri:cut=" and" id="af88"><addr-line>Department of Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Department of Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name><affiliation><nlm:aff id="af36"><addr-line>Division of Preventive Medicine</addr-line>,<institution>Brigham and Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af23"><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos Santos Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="af85"><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name><affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name><affiliation><nlm:aff wicri:cut=" and" id="af90"><addr-line>Department of Surgery</addr-line>,<institution>Umeå University</institution>,<addr-line>Umea</addr-line>,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Tapper, William J" sort="Tapper, William J" uniqKey="Tapper W" first="William J." last="Tapper">William J. Tapper</name><affiliation><nlm:aff id="af11"><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Thun, Michael J" sort="Thun, Michael J" uniqKey="Thun M" first="Michael J." last="Thun">Michael J. Thun</name><affiliation><nlm:aff id="af46"><addr-line>Epidemiology Research Program</addr-line>,<institution>American Cancer Society</institution>,<addr-line>Atlanta, GA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="af91"><addr-line>Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation><nlm:aff wicri:cut=" and" id="af49"><addr-line>Section of Cancer Genetics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="af86"><addr-line>Department of Internal Medicine and Epidemiology</addr-line>,<institution>Erasmus Medical Center</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Waisfisz, Quinten" sort="Waisfisz, Quinten" uniqKey="Waisfisz Q" first="Quinten" last="Waisfisz">Quinten Waisfisz</name><affiliation><nlm:aff id="af78"><addr-line>Department of Clinical Genetics</addr-line>,<institution>VU University Medical Center, section Oncogenetics</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff wicri:cut=" and" id="af4"><addr-line>Department of Laboratory Medicine and Pathology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation><nlm:aff id="af31"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="af67"><addr-line>Core Genotyping Facility</addr-line>,<institution>SAIC-Frederick Inc., NCI-Frederick</institution>,<addr-line>Frederick, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Weaver, Joellen" sort="Weaver, Joellen" uniqKey="Weaver J" first="Joellen" last="Weaver">Joellen Weaver</name><affiliation><nlm:aff id="af89"><addr-line>Biosample Repository</addr-line>,<institution>Fox Chase Cancer Center</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Schulz Wendtland, Rudiger" sort="Schulz Wendtland, Rudiger" uniqKey="Schulz Wendtland R" first="Rüdiger" last="Schulz-Wendtland">Rüdiger Schulz-Wendtland</name><affiliation><nlm:aff id="af29"><addr-line>Institute of Diagnostic Radiology</addr-line>,<institution>Friedrich-Alexander University Erlangen-Nuremberg</institution>,<institution>University Hospital Erlangen</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Wilkens, Lynne R" sort="Wilkens, Lynne R" uniqKey="Wilkens L" first="Lynne R." last="Wilkens">Lynne R. Wilkens</name><affiliation><nlm:aff id="af71"><addr-line>Epidemiology Program</addr-line>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, David" sort="Van Den Berg, David" uniqKey="Van Den Berg D" first="David" last="Van Den Berg">David Van Den Berg</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="af45"><addr-line>Division of Epidemiology, Department of Medicine</addr-line>,<institution>Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G." last="Ziegler">Regina G. Ziegler</name><affiliation><nlm:aff id="af31"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Ziv, Elad" sort="Ziv, Elad" uniqKey="Ziv E" first="Elad" last="Ziv">Elad Ziv</name><affiliation><nlm:aff id="af52"><addr-line>Division of General Internal Medicine, Department of Medicine, Institute for Human Genetics and Helen Diller Family Comprehensive Cancer Center</addr-line>,<institution>University of California</institution>,<addr-line>San Francisco, CA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff wicri:cut=" and" id="af18"><addr-line>Department of Obstetrics and Gynecology</addr-line>,<institution>University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="af14"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff wicri:cut=" and" id="af9"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af10"><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="af31"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation><nlm:aff id="af50"><addr-line>Section of Epidemiology and Genetics</addr-line>,<institution>Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff wicri:cut=" and" id="af9"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Preventive Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine M" sort="Vachon, Celine M" uniqKey="Vachon C" first="Celine M." last="Vachon">Celine M. Vachon</name><affiliation><nlm:aff id="af3"><addr-line>Department of Health Sciences Research</addr-line>,</nlm:aff></affiliation></author></analytic><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Genome-wide association studies (GWAS) of breast cancer defined by hormone receptor status have revealed loci contributing to susceptibility of estrogen receptor (ER)-negative subtypes. To identify additional genetic variants for ER-negative breast cancer, we conducted the largest meta-analysis of ER-negative disease to date, comprising 4754 ER-negative cases and 31 663 controls from three GWAS: NCI Breast and Prostate Cancer Cohort Consortium (BPC3) (2188 ER-negative cases; 25 519 controls of European ancestry), Triple Negative Breast Cancer Consortium (TNBCC) (1562 triple negative cases; 3399 controls of European ancestry) and African American Breast Cancer Consortium (AABC) (1004 ER-negative cases; 2745 controls). We performed <italic>in silico</italic> replication of 86 SNPs at <italic>P</italic> ≤ 1 × 10<sup>-5</sup> in an additional 11 209 breast cancer cases (946 with ER-negative disease) and 16 057 controls of Japanese, Latino and European ancestry. We identified two novel loci for breast cancer at 20q11 and 6q14. SNP rs2284378 at 20q11 was associated with ER-negative breast cancer (combined two-stage OR = 1.16; <italic>P</italic> = 1.1 × 10<sup>−8</sup>) but showed a weaker association with overall breast cancer (OR = 1.08, <italic>P</italic> = 1.3 × 10<sup>–6</sup>) based on 17 869 cases and 43 745 controls and no association with ER-positive disease (OR = 1.01, <italic>P</italic> = 0.67) based on 9965 cases and 22 902 controls. Similarly, rs17530068 at 6q14 was associated with breast cancer (OR = 1.12; <italic>P</italic> = 1.1 × 10<sup>−9</sup>), and with both ER-positive (OR = 1.09; <italic>P</italic> = 1.5 × 10<sup>−5</sup>) and ER-negative (OR = 1.16, <italic>P</italic> = 2.5 × 10<sup>−7</sup>) disease. We also confirmed three known loci associated with ER-negative (19p13) and both ER-negative and ER-positive breast cancer (6q25 and 12p11). Our results highlight the value of large-scale collaborative studies to identify novel breast cancer risk loci.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Mol Genet</journal-id><journal-id journal-id-type="iso-abbrev">Hum. Mol. Genet</journal-id><journal-id journal-id-type="publisher-id">hmg</journal-id><journal-id journal-id-type="hwp">hmg</journal-id><journal-title-group><journal-title>Human Molecular Genetics</journal-title></journal-title-group><issn pub-type="ppub">0964-6906</issn><issn pub-type="epub">1460-2083</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22976474</article-id><article-id pub-id-type="pmc">3510753</article-id><article-id pub-id-type="doi">10.1093/hmg/dds381</article-id><article-id pub-id-type="publisher-id">dds381</article-id><article-categories><subj-group subj-group-type="heading"><subject>Association Studies Articles</subject></subj-group></article-categories><title-group><article-title>A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11</article-title></title-group><contrib-group><contrib 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contrib-type="author"><name><surname>Schulz-Wendtland</surname><given-names>Rüdiger</given-names></name><xref ref-type="aff" rid="af29">29</xref></contrib><contrib contrib-type="author"><name><surname>Wilkens</surname><given-names>Lynne R.</given-names></name><xref ref-type="aff" rid="af71">71</xref></contrib><contrib contrib-type="author"><name><surname>Van Den Berg</surname><given-names>David</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Wei</given-names></name><xref ref-type="aff" rid="af45">45</xref></contrib><contrib contrib-type="author"><name><surname>Ziegler</surname><given-names>Regina G.</given-names></name><xref ref-type="aff" rid="af31">31</xref></contrib><contrib contrib-type="author"><name><surname>Ziv</surname><given-names>Elad</given-names></name><xref ref-type="aff" rid="af52">52</xref></contrib><contrib contrib-type="author"><name><surname>Nevanlinna</surname><given-names>Heli</given-names></name><xref ref-type="aff" rid="af18">18</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="af14">14</xref></contrib><contrib contrib-type="author"><name><surname>Hunter</surname><given-names>David J.</given-names></name><xref ref-type="aff" rid="af9">9</xref><xref ref-type="aff" rid="af10">10</xref></contrib><contrib contrib-type="author"><name><surname>Henderson</surname><given-names>Brian E.</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Chanock</surname><given-names>Stephen J.</given-names></name><xref ref-type="aff" rid="af31">31</xref></contrib><contrib contrib-type="author"><name><surname>Garcia-Closas</surname><given-names>Montserrat</given-names></name><xref ref-type="aff" rid="af50">50</xref></contrib><contrib contrib-type="author"><name><surname>Kraft</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="af9">9</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Haiman</surname><given-names>Christopher A.</given-names></name><xref ref-type="aff" rid="af6">6</xref><xref ref-type="corresp" rid="cor1">*</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Vachon</surname><given-names>Celine M.</given-names></name><xref ref-type="aff" rid="af3">3</xref><xref ref-type="corresp" rid="cor1">*</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>Department of Epidemiology and Biostatistics</addr-line> and</aff><aff id="af2"><label>2</label><addr-line>Department of Genomics of Common Disease, School of Public Health</addr-line>,<institution>Imperial College London</institution>,<addr-line>London</addr-line><country>, UK</country>,</aff><aff id="af3"><label>3</label><addr-line>Department of Health Sciences Research</addr-line>,</aff><aff id="af4"><label>4</label><addr-line>Department of Laboratory Medicine and Pathology</addr-line> and</aff><aff id="af5"><label>5</label><addr-line>Department of Pharmacology</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>USA</country>,</aff><aff id="af6"><label>6</label><addr-line>Department of Preventive Medicine</addr-line> and</aff><aff id="af7"><label>7</label><addr-line>Department of Pathology</addr-line>,<institution>Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</aff><aff id="af8"><label>8</label><addr-line>Department of Urology</addr-line>,<institution>Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA 90089</addr-line>,<country>USA</country>,</aff><aff id="af9"><label>9</label><addr-line>Program in Molecular and Genetic Epidemiology</addr-line> and</aff><aff id="af10"><label>10</label><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</aff><aff id="af11"><label>11</label><addr-line>Faculty of Medicine</addr-line>,<institution>University of Southampton</institution>,<addr-line>Southampton</addr-line>,<country>UK</country>,</aff><aff id="af12"><label>12</label><addr-line>Department of Epidemiology, Gillings School of Global Public Health, and Lineberger Comprehensive Cancer Center</addr-line>,<institution>University of North Carolina</institution>,<addr-line>Chapel Hill, NC</addr-line>,<country>USA</country>,</aff><aff id="af13"><label>13</label><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care</addr-line> and</aff><aff id="af14"><label>14</label><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</aff><aff id="af15"><label>15</label><addr-line>Institute for Quality and Efficiency in Health Care</addr-line>,<institution>IQWiG</institution>,<addr-line>Cologne</addr-line>,<country>Germany</country>,</aff><aff id="af16"><label>16</label><addr-line>Department of Cancer Prevention and Control</addr-line>,<institution>Roswell Park Cancer Institute</institution>,<addr-line>Buffalo, NY</addr-line>,<country>USA</country>,</aff><aff id="af17"><label>17</label><addr-line>Department of Clinical Genetics</addr-line> and</aff><aff id="af18"><label>18</label><addr-line>Department of Obstetrics and Gynecology</addr-line>,<institution>University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country> and</aff><aff id="af19"><label>19</label><addr-line>Department of Oncology</addr-line>,<institution>Helsinki University Central Hospital</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</aff><aff id="af20"><label>20</label><institution>Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP)</institution>,<addr-line>Madrid</addr-line>,<country>Spain</country>,</aff><aff id="af21"><label>21</label><addr-line>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health</addr-line> and</aff><aff id="af22"><label>22</label><addr-line>Genetic Epidemiology Laboratory, Department of Pathology</addr-line>,<institution>The University of Melbourne</institution>,<country>Australia</country>,</aff><aff id="af23"><label>23</label><addr-line>Cancer Epidemiology Centre</addr-line>,<institution>The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</aff><aff id="af24"><label>24</label><addr-line>Australian Breast Cancer Tissue Bank, Westmead Millennium Institute</addr-line> and</aff><aff id="af25"><label>25</label><addr-line>ABCTB</addr-line>,<institution>University of Sydney</institution>,<addr-line>NSW</addr-line>,<country>Australia</country>,</aff><aff id="af26"><label>26</label><institution>The Cancer Institute of New Jersey</institution>,<addr-line>New Brunswick, NJ</addr-line>,<country>USA</country>,</aff><aff id="af27"><label>27</label><addr-line>Department of Gynecology and Obstetrics</addr-line>,<institution>Friedrich-Alexander University Erlangen-Nuremberg</institution>,<institution>University Hospital Erlangen</institution>,<institution>University Breast Center Franconia</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country>,</aff><aff id="af28"><label>28</label><addr-line>Institute of Pathology</addr-line> and</aff><aff id="af29"><label>29</label><addr-line>Institute of Diagnostic Radiology</addr-line>,<institution>Friedrich-Alexander University Erlangen-Nuremberg</institution>,<institution>University Hospital Erlangen</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country>,</aff><aff id="af30"><label>30</label><addr-line>Early Detection Research Group, Division of Cancer Prevention</addr-line> and</aff><aff id="af31"><label>31</label><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Rockville, MD</addr-line>,<country>USA</country>,</aff><aff id="af32"><label>32</label><addr-line>Division of Cancer Etiology, Department of Population Science</addr-line>,<institution>Beckman Research Institute</institution>,<addr-line>City of Hope, CA</addr-line>,<country>USA</country>,</aff><aff id="af33"><label>33</label><addr-line>Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology</addr-line> and</aff><aff id="af34"><label>34</label><addr-line>Gene Environment Interaction and Breast Cancer in Germany (GENICA): Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology</addr-line>,<institution>University Tübingen</institution>,<addr-line>Stuttgart</addr-line>,<country>Germany</country>,</aff><aff id="af35"><label>35</label><addr-line>Brigham and Women's Hospital and Harvard Medical School, Boston, MA</addr-line>,<country>USA</country>,</aff><aff id="af36"><label>36</label><addr-line>Division of Preventive Medicine</addr-line>,<institution>Brigham and Women's Hospital and Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</aff><aff id="af37"><label>37</label><addr-line>Huntsman Cancer Institute</addr-line>,<institution>University of Utah</institution>,<addr-line>Salt Lake City, UT</addr-line>,<country>USA</country>,</aff><aff id="af38"><label>38</label><addr-line>Genomic Epidemiology Group</addr-line> and</aff><aff id="af39"><label>39</label><addr-line>Division of Cancer Epidemiology</addr-line>,<institution>German Cancer Research Center</institution> and</aff><aff id="af40"><label>40</label><addr-line>Molecular Genetics of Breast Cancer</addr-line>,<institution>Deutsches Krebsforschungszentrum (DKFZ)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="af41"><label>41</label><addr-line>INSERM UMR 1018, Team 9: Nutrition, Hormones et Santé desfemmes, Centre de Recherche en Epidémiologie et Santé des Populations</addr-line>,<institution>Hôpital Paul Brousse</institution>,<addr-line>Villejuif</addr-line>,<country>France</country>,</aff><aff id="af42"><label>42</label><addr-line>Institute for Cancer Studies, Department of Oncology</addr-line> and</aff><aff id="af43"><label>43</label><addr-line>Academic Unit of Pathology, Department of Neuroscience, Faculty of Medicine, Dentistry and Health</addr-line>,<institution>University of Sheffield</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country>,</aff><aff id="af44"><label>44</label><addr-line>Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm 17177</addr-line>,<country>Sweden</country>,</aff><aff id="af45"><label>45</label><addr-line>Division of Epidemiology, Department of Medicine</addr-line>,<institution>Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN</addr-line>,<country>USA</country>,</aff><aff id="af46"><label>46</label><addr-line>Epidemiology Research Program</addr-line>,<institution>American Cancer Society</institution>,<addr-line>Atlanta, GA</addr-line>,<country>USA</country>,</aff><aff id="af47"><label>47</label><institution>Friedrich-Alexander University Erlangen-Nuremberg, Institute of Human Genetics</institution>,<addr-line>Erlangen</addr-line>,<country>Germany</country>,</aff><aff id="af48"><label>48</label><addr-line>David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology</addr-line>,<institution>University of California at Los Angeles</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</aff><aff id="af49"><label>49</label><addr-line>Section of Cancer Genetics</addr-line> and</aff><aff id="af50"><label>50</label><addr-line>Section of Epidemiology and Genetics</addr-line>,<institution>Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country>,</aff><aff id="af51"><label>51</label><addr-line>Institute for Health Research</addr-line>,<institution>Kaiser Permanente</institution>,<addr-line>Denver, CO</addr-line>,<country>USA</country>,</aff><aff id="af52"><label>52</label><addr-line>Division of General Internal Medicine, Department of Medicine, Institute for Human Genetics and Helen Diller Family Comprehensive Cancer Center</addr-line>,<institution>University of California</institution>,<addr-line>San Francisco, CA</addr-line>,<country>USA</country>,</aff><aff id="af53"><label>53</label><addr-line>Institute of Cancer Research</addr-line>,<institution>Breakthrough Breast Cancer Research Centre</institution>,<addr-line>London</addr-line>,<country>UK</country>,</aff><aff id="af54"><label>54</label><addr-line>Department of Cancer Epidemiology/Clinical Cancer Registry</addr-line>,<institution>University Cancer Center Hamburg (UCCH)</institution> ,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</aff><aff id="af55"><label>55</label><addr-line>Department of Medical Biometrics and Epidemiology</addr-line>,<institution>University Medical Center Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country>,</aff><aff id="af56"><label>56</label><addr-line>Department of Internal Medicine</addr-line>,<institution>Evangelische Kliniken Bonn gGmbH</institution>,<addr-line>Johanniter Krankenhaus, Bonn</addr-line>,<country>Germany</country>,</aff><aff id="af57"><label>57</label><addr-line>Institute of Pathology</addr-line>,<institution>Medical Faculty of the University of Bonn</institution>,<country>Germany</country>,</aff><aff id="af58"><label>58</label><institution>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)</institution>,<addr-line>Bochum</addr-line>,<country>Germany</country>,</aff><aff id="af59"><label>59</label><addr-line>Institute and Outpatient Clinic of Occupational Medicine</addr-line>,<institution>Saarland University Medical Center and Saarland University Faculty of Medicine</institution>,<addr-line>Homburg</addr-line>,<country>Germany</country>,</aff><aff id="af60"><label>60</label><addr-line>Sylvester Comprehensive Cancer Center and Department of Epidemiology and Public Health</addr-line>,<institution>University of Miami Miller School of Medicine</institution>,<addr-line>Miami, FL</addr-line>,<country>USA</country>,</aff><aff id="af61"><label>61</label><institution>Julius Center, University Medical Center</institution>,<addr-line>Utrecht</addr-line>,<country>The Netherlands</country>,</aff><aff id="af62"><label>62</label><addr-line>Department of Pathology and Laboratory Medicine</addr-line>,<institution>Kansas University Medical Center</institution>,<addr-line>Kansas City, KS</addr-line>,<country>USA</country>,</aff><aff id="af63"><label>63</label><addr-line>PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy</addr-line> and</aff><aff id="af64"><label>64</label><addr-line>Division of Molecular Gynaeco-Oncology, Department of Obstetrics and Gynaecology</addr-line>,<institution>University of Cologne</institution>,<addr-line>Cologne</addr-line>,<country>Germany</country>,</aff><aff id="af65"><label>65</label><addr-line>Human Genetics Division</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</aff><aff id="af66"><label>66</label><addr-line>Lombardi Comprehensive Cancer Center</addr-line>,<institution>Georgetown University</institution>,<addr-line>Washington, DC</addr-line>,<country>USA</country>,</aff><aff id="af67"><label>67</label><addr-line>Core Genotyping Facility</addr-line>,<institution>SAIC-Frederick Inc., NCI-Frederick</institution>,<addr-line>Frederick, MD</addr-line>,<country>USA</country>,</aff><aff id="af68"><label>68</label><institution>Bioinformed Consulting Services</institution>,<addr-line>Gaithersburg, MD</addr-line>,<country>USA</country>,</aff><aff id="af69"><label>69</label><addr-line>Cancer Prevention Institute of California, Fremont, CA</addr-line>,<country>USA</country>,</aff><aff id="af70"><label>70</label><addr-line>Stanford University School of Medicine</addr-line>,<institution>Stanford Cancer Institute</institution>,<addr-line>Stanford, CA</addr-line>,<country>USA</country>,</aff><aff id="af71"><label>71</label><addr-line>Epidemiology Program</addr-line>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</aff><aff id="af72"><label>72</label><institution>Centre National de Genotypage</institution>,<addr-line>Evry</addr-line>,<country>France</country>,</aff><aff id="af73"><label>73</label><institution>Fondation Jean Dausset, CEPH</institution>,<addr-line>Paris</addr-line>,<country>France</country>,</aff><aff id="af74"><label>74</label><addr-line>Institute of Human Genetics</addr-line>,<institution>Helmholtz Zentrum München, German Research Center for Environmental Health</institution>,<addr-line>Neuherberg</addr-line>,<country>Germany</country>,</aff><aff id="af75"><label>75</label><addr-line>Institute of Community Medicine</addr-line>,<institution>University of Tromsø</institution>,<addr-line>Tromsø</addr-line>,<country>Norway</country>,</aff><aff id="af76"><label>76</label><addr-line>QIMR GWAS Collective</addr-line>,<institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country>,</aff><aff id="af77"><label>77</label><institution>The Alfred Hospital</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</aff><aff id="af78"><label>78</label><addr-line>Department of Clinical Genetics</addr-line>,<institution>VU University Medical Center, section Oncogenetics</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country>,</aff><aff id="af79"><label>79</label><addr-line>Clinic of Gynaecology and Obstetrics, Division for Gynaecological Tumor-Genetics</addr-line>,<institution>Technische Universität München</institution>,<addr-line>München</addr-line>,<country>Germany</country>,</aff><aff id="af80"><label>80</label><institution>Dana Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</aff><aff id="af81"><label>81</label><institution>Max Planck Institute of Psychiatry</institution>,<addr-line>Munich</addr-line>,<country>Germany</country>,</aff><aff id="af82"><label>82</label><addr-line>Department of Cardiology, Center for Cardiovascular Research</addr-line>,<institution>Aalborg Hospital</institution>,<institution>Aarhus University Hospital</institution>,<addr-line>Aalborg</addr-line>,<country>Denmark</country>,</aff><aff id="af83"><label>83</label><addr-line>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute</addr-line>,<institution>ISPO</institution>,<addr-line>Florence</addr-line>,<country>Italy</country>,</aff><aff id="af84"><label>84</label><institution>Slone Epidemiology Center at Boston University</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</aff><aff id="af85"><label>85</label><addr-line>Non-communicable Disease Epidemiology Department</addr-line>,<institution>London School of Hygiene and Tropical Medicine</institution>,<addr-line>London</addr-line>,<country>UK</country>,</aff><aff id="af86"><label>86</label><addr-line>Department of Internal Medicine and Epidemiology</addr-line>,<institution>Erasmus Medical Center</institution>,<addr-line>Rotterdam</addr-line>,<country>The Netherlands</country>,</aff><aff id="af87"><label>87</label><addr-line>Department of Pathology</addr-line>,<institution>University Hospital Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="af88"><label>88</label><addr-line>Department of Biostatistics</addr-line> and</aff><aff id="af89"><label>89</label><addr-line>Biosample Repository</addr-line>,<institution>Fox Chase Cancer Center</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>USA</country>,</aff><aff id="af90"><label>90</label><addr-line>Department of Surgery</addr-line>,<institution>Umeå University</institution>,<addr-line>Umea</addr-line>,<country>Sweden</country> and</aff><aff id="af91"><label>91</label><addr-line>Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country></aff><author-notes><corresp id="cor1"><label>*</label>To whom correspondence should be addressed at: Mayo Clinic, 200 First St SW, Charlton 6-239, Rochester, MN 55905, USA. Tel: +<phone>1 5072849977</phone>; Fax: +<fax>1 5072662478</fax>; Email: <email>vachon.celine@mayo.edu</email> (C.M.V.); Harlyne Norris Research Tower, 1450 Biggy Street, Room 1504, Los Angeles, CA 90033, USA. Email: <email>christopher.haiman@med.usc.edu</email> (C.A.H.)</corresp><fn id="AN1"><label>†</label><p>These authors contributed equally.</p></fn></author-notes><pub-date pub-type="ppub"><day>15</day><month>12</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>13</day><month>9</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>12</month><year>2013</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>21</volume><issue>24</issue><fpage>5373</fpage><lpage>5384</lpage><history><date date-type="received"><day>26</day><month>3</month><year>2012</year></date><date date-type="accepted"><day>6</day><month>9</month><year>2012</year></date></history><permissions><copyright-statement>© The Author 2012. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="dds381.pdf"></self-uri><abstract><p>Genome-wide association studies (GWAS) of breast cancer defined by hormone receptor status have revealed loci contributing to susceptibility of estrogen receptor (ER)-negative subtypes. To identify additional genetic variants for ER-negative breast cancer, we conducted the largest meta-analysis of ER-negative disease to date, comprising 4754 ER-negative cases and 31 663 controls from three GWAS: NCI Breast and Prostate Cancer Cohort Consortium (BPC3) (2188 ER-negative cases; 25 519 controls of European ancestry), Triple Negative Breast Cancer Consortium (TNBCC) (1562 triple negative cases; 3399 controls of European ancestry) and African American Breast Cancer Consortium (AABC) (1004 ER-negative cases; 2745 controls). We performed <italic>in silico</italic> replication of 86 SNPs at <italic>P</italic> ≤ 1 × 10<sup>-5</sup> in an additional 11 209 breast cancer cases (946 with ER-negative disease) and 16 057 controls of Japanese, Latino and European ancestry. We identified two novel loci for breast cancer at 20q11 and 6q14. SNP rs2284378 at 20q11 was associated with ER-negative breast cancer (combined two-stage OR = 1.16; <italic>P</italic> = 1.1 × 10<sup>−8</sup>) but showed a weaker association with overall breast cancer (OR = 1.08, <italic>P</italic> = 1.3 × 10<sup>–6</sup>) based on 17 869 cases and 43 745 controls and no association with ER-positive disease (OR = 1.01, <italic>P</italic> = 0.67) based on 9965 cases and 22 902 controls. Similarly, rs17530068 at 6q14 was associated with breast cancer (OR = 1.12; <italic>P</italic> = 1.1 × 10<sup>−9</sup>), and with both ER-positive (OR = 1.09; <italic>P</italic> = 1.5 × 10<sup>−5</sup>) and ER-negative (OR = 1.16, <italic>P</italic> = 2.5 × 10<sup>−7</sup>) disease. We also confirmed three known loci associated with ER-negative (19p13) and both ER-negative and ER-positive breast cancer (6q25 and 12p11). Our results highlight the value of large-scale collaborative studies to identify novel breast cancer risk loci.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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