Wiring the Brain: The Biology of Neuronal Guidance
Identifieur interne : 001834 ( Pmc/Corpus ); précédent : 001833; suivant : 001835Wiring the Brain: The Biology of Neuronal Guidance
Auteurs : Alain Chédotal ; Linda J. RichardsSource :
- Cold Spring Harbor Perspectives in Biology [ 1943-0264 ] ; 2010.
Abstract
The mammalian brain is the most complex organ in the body. It controls all aspects of our bodily functions and interprets the world around us through our senses. It defines us as human beings through our memories and our ability to plan for the future. Crucial to all these functions is how the brain is wired in order to perform these tasks. The basic map of brain wiring occurs during embryonic and postnatal development through a series of precisely orchestrated developmental events regulated by specific molecular mechanisms. Below we review the most important features of mammalian brain wiring derived from work in both mammals and in nonmammalian species. These mechanisms are highly conserved throughout evolution, simply becoming more complex in the mammalian brain. This fascinating area of biology is uncovering the essence of what makes the mammalian brain able to perform the everyday tasks we take for granted, as well as those which give us the ability for extraordinary achievement.
Url:
DOI: 10.1101/cshperspect.a001917
PubMed: 20463002
PubMed Central: 2869517
Links to Exploration step
PMC:2869517Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Wiring the Brain: The Biology of Neuronal Guidance</title><author><name sortKey="Chedotal, Alain" sort="Chedotal, Alain" uniqKey="Chedotal A" first="Alain" last="Chédotal">Alain Chédotal</name><affiliation><nlm:aff id="af1">INSERM UMRS_968, Institut de la Vision, Department of Development, 17 rue Moreau, 75012 Paris, France; UPMC Univ Paris 06, UMRS_968, F-75012 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Richards, Linda J" sort="Richards, Linda J" uniqKey="Richards L" first="Linda J." last="Richards">Linda J. Richards</name><affiliation><nlm:aff id="af2">The University of Queensland, Queensland Brain Institute and School of Biomedical Sciences, Buidling 79, St Lucia Campus, St Luica, Queensland, Australia, 4072</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20463002</idno><idno type="pmc">2869517</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869517</idno><idno type="RBID">PMC:2869517</idno><idno type="doi">10.1101/cshperspect.a001917</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">001834</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001834</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Wiring the Brain: The Biology of Neuronal Guidance</title><author><name sortKey="Chedotal, Alain" sort="Chedotal, Alain" uniqKey="Chedotal A" first="Alain" last="Chédotal">Alain Chédotal</name><affiliation><nlm:aff id="af1">INSERM UMRS_968, Institut de la Vision, Department of Development, 17 rue Moreau, 75012 Paris, France; UPMC Univ Paris 06, UMRS_968, F-75012 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Richards, Linda J" sort="Richards, Linda J" uniqKey="Richards L" first="Linda J." last="Richards">Linda J. Richards</name><affiliation><nlm:aff id="af2">The University of Queensland, Queensland Brain Institute and School of Biomedical Sciences, Buidling 79, St Lucia Campus, St Luica, Queensland, Australia, 4072</nlm:aff></affiliation></author></analytic><series><title level="j">Cold Spring Harbor Perspectives in Biology</title><idno type="eISSN">1943-0264</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The mammalian brain is the most complex organ in the body. It controls all aspects of our bodily functions and interprets the world around us through our senses. It defines us as human beings through our memories and our ability to plan for the future. Crucial to all these functions is how the brain is wired in order to perform these tasks. The basic map of brain wiring occurs during embryonic and postnatal development through a series of precisely orchestrated developmental events regulated by specific molecular mechanisms. Below we review the most important features of mammalian brain wiring derived from work in both mammals and in nonmammalian species. These mechanisms are highly conserved throughout evolution, simply becoming more complex in the mammalian brain. This fascinating area of biology is uncovering the essence of what makes the mammalian brain able to perform the everyday tasks we take for granted, as well as those which give us the ability for extraordinary achievement.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cold Spring Harb Perspect Biol</journal-id><journal-id journal-id-type="publisher-id">cshperspect</journal-id><journal-id journal-id-type="hwp">cshperspect</journal-id><journal-title-group><journal-title>Cold Spring Harbor Perspectives in Biology</journal-title></journal-title-group><issn pub-type="epub">1943-0264</issn><publisher><publisher-name>Cold Spring Harbor Laboratory Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20463002</article-id><article-id pub-id-type="pmc">2869517</article-id><article-id pub-id-type="doi">10.1101/cshperspect.a001917</article-id><article-id pub-id-type="publisher-id">a001917</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>006</subject></subj-group><subj-group subj-group-type="heading"><subject>Perspectives</subject><subj-group><subject>Neurobiology</subject></subj-group></subj-group></article-categories><title-group><article-title>Wiring the Brain: The Biology of Neuronal Guidance</article-title><alt-title alt-title-type="left-running">A. Chédotal and L.J. Richards</alt-title><alt-title alt-title-type="right-running">Wiring the Mammalian Brain</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chédotal</surname><given-names>Alain</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Richards</surname><given-names>Linda J.</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib></contrib-group><aff id="af1"><label>1</label>INSERM UMRS_968, Institut de la Vision, Department of Development, 17 rue Moreau, 75012 Paris, France; UPMC Univ Paris 06, UMRS_968, F-75012 Paris, France</aff><aff id="af2"><label>2</label>The University of Queensland, Queensland Brain Institute and School of Biomedical Sciences, Buidling 79, St Lucia Campus, St Luica, Queensland, Australia, 4072</aff><author-notes><corresp><italic>Correspondence:</italic><email>richards@uq.edu.au</email></corresp></author-notes><pub-date pub-type="ppub"><month>6</month><year>2010</year></pub-date><volume>2</volume><issue>6</issue><elocation-id>a001917</elocation-id><permissions><copyright-statement>Copyright © 2010 Cold Spring Harbor Laboratory Press; all rights reserved</copyright-statement></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="cshperspect-AXN-a001917.pdf"></self-uri><abstract><p>The mammalian brain is the most complex organ in the body. It controls all aspects of our bodily functions and interprets the world around us through our senses. It defines us as human beings through our memories and our ability to plan for the future. Crucial to all these functions is how the brain is wired in order to perform these tasks. The basic map of brain wiring occurs during embryonic and postnatal development through a series of precisely orchestrated developmental events regulated by specific molecular mechanisms. Below we review the most important features of mammalian brain wiring derived from work in both mammals and in nonmammalian species. These mechanisms are highly conserved throughout evolution, simply becoming more complex in the mammalian brain. This fascinating area of biology is uncovering the essence of what makes the mammalian brain able to perform the everyday tasks we take for granted, as well as those which give us the ability for extraordinary achievement.</p></abstract><abstract abstract-type="precis"><p>Pioneer axons first set the stage for the general axonal map of the brain. Second, neuronal populations are generated and specified by the expression of transcription factors, with these neurons sending out axons that grow towards their final targets through the use of intermediate targets such as glial and corridor cells along the pathway. Target and synapse specificity in the region of the final target is coordinated both through molecular and activity-dependent mechanisms.</p></abstract><counts><page-count count="17"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001834 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001834 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé= PMC:2869517
|texte= Wiring the Brain: The Biology of Neuronal Guidance
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:20463002" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |