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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Stroke: Working toward a Prioritized World Agenda</title><author><name sortKey="Hachinski, Vladimir" sort="Hachinski, Vladimir" uniqKey="Hachinski V" first="Vladimir" last="Hachinski">Vladimir Hachinski</name></author><author><name sortKey="Donnan, Geoffrey A" sort="Donnan, Geoffrey A" uniqKey="Donnan G" first="Geoffrey A." last="Donnan">Geoffrey A. Donnan</name></author><author><name sortKey="Gorelick, Philip B" sort="Gorelick, Philip B" uniqKey="Gorelick P" first="Philip B." last="Gorelick">Philip B. Gorelick</name></author><author><name sortKey="Hacke, Werner" sort="Hacke, Werner" uniqKey="Hacke W" first="Werner" last="Hacke">Werner Hacke</name></author><author><name sortKey="Cramer, Steven C" sort="Cramer, Steven C" uniqKey="Cramer S" first="Steven C." last="Cramer">Steven C. Cramer</name></author><author><name sortKey="Kaste, Markku" sort="Kaste, Markku" uniqKey="Kaste M" first="Markku" last="Kaste">Markku Kaste</name></author><author><name sortKey="Fisher, Marc" sort="Fisher, Marc" uniqKey="Fisher M" first="Marc" last="Fisher">Marc Fisher</name></author><author><name sortKey="Brainin, Michael" sort="Brainin, Michael" uniqKey="Brainin M" first="Michael" last="Brainin">Michael Brainin</name></author><author><name sortKey="Buchan, Alastair M" sort="Buchan, Alastair M" uniqKey="Buchan A" first="Alastair M." last="Buchan">Alastair M. Buchan</name></author><author><name sortKey="Lo, Eng H" sort="Lo, Eng H" uniqKey="Lo E" first="Eng H." last="Lo">Eng H. Lo</name></author><author><name sortKey="Skolnick, Brett E" sort="Skolnick, Brett E" uniqKey="Skolnick B" first="Brett E." last="Skolnick">Brett E. Skolnick</name></author><author><name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L." last="Furie">Karen L. Furie</name></author><author><name sortKey="Hankey, Graeme J" sort="Hankey, Graeme J" uniqKey="Hankey G" first="Graeme J." last="Hankey">Graeme J. Hankey</name></author><author><name sortKey="Kivipelto, Miia" sort="Kivipelto, Miia" uniqKey="Kivipelto M" first="Miia" last="Kivipelto">Miia Kivipelto</name></author><author><name sortKey="Morris, John" sort="Morris, John" uniqKey="Morris J" first="John" last="Morris">John Morris</name></author><author><name sortKey="Rothwell, Peter M" sort="Rothwell, Peter M" uniqKey="Rothwell P" first="Peter M." last="Rothwell">Peter M. Rothwell</name></author><author><name sortKey="Sacco, Ralph L" sort="Sacco, Ralph L" uniqKey="Sacco R" first="Ralph L." last="Sacco">Ralph L. Sacco</name></author><author><name sortKey="Smith Jr, Sidney C" sort="Smith Jr, Sidney C" uniqKey="Smith Jr S" first="Sidney C." last="Smith Jr.">Sidney C. Smith Jr.</name></author><author><name sortKey="Wang, Yulun" sort="Wang, Yulun" uniqKey="Wang Y" first="Yulun" last="Wang">Yulun Wang</name></author><author><name sortKey="Bryer, Alan" sort="Bryer, Alan" uniqKey="Bryer A" first="Alan" last="Bryer">Alan Bryer</name></author><author><name sortKey="Ford, Gary A" sort="Ford, Gary A" uniqKey="Ford G" first="Gary A." last="Ford">Gary A. Ford</name></author><author><name sortKey="Iadecola, Costantino" sort="Iadecola, Costantino" uniqKey="Iadecola C" first="Costantino" last="Iadecola">Costantino Iadecola</name></author><author><name sortKey="Martins, Sheila C O" sort="Martins, Sheila C O" uniqKey="Martins S" first="Sheila C. O." last="Martins">Sheila C. O. Martins</name></author><author><name sortKey="Saver, Jeff" sort="Saver, Jeff" uniqKey="Saver J" first="Jeff" last="Saver">Jeff Saver</name></author><author><name sortKey="Skvortsova, Veronika" sort="Skvortsova, Veronika" uniqKey="Skvortsova V" first="Veronika" last="Skvortsova">Veronika Skvortsova</name></author><author><name sortKey="Bayley, Mark" sort="Bayley, Mark" uniqKey="Bayley M" first="Mark" last="Bayley">Mark Bayley</name></author><author><name sortKey="Bednar, Martin M" sort="Bednar, Martin M" uniqKey="Bednar M" first="Martin M." last="Bednar">Martin M. Bednar</name></author><author><name sortKey="Duncan, Pamela" sort="Duncan, Pamela" uniqKey="Duncan P" first="Pamela" last="Duncan">Pamela Duncan</name></author><author><name sortKey="Enney, Lori" sort="Enney, Lori" uniqKey="Enney L" first="Lori" last="Enney">Lori Enney</name></author><author><name sortKey="Finklestein, Seth" sort="Finklestein, Seth" uniqKey="Finklestein S" first="Seth" last="Finklestein">Seth Finklestein</name></author><author><name sortKey="Jones, Theresa A" sort="Jones, Theresa A" uniqKey="Jones T" first="Theresa A." last="Jones">Theresa A. Jones</name></author><author><name sortKey="Kalra, Lalit" sort="Kalra, Lalit" uniqKey="Kalra L" first="Lalit" last="Kalra">Lalit Kalra</name></author><author><name sortKey="Kleim, Jeff" sort="Kleim, Jeff" uniqKey="Kleim J" first="Jeff" last="Kleim">Jeff Kleim</name></author><author><name sortKey="Nitkin, Ralph" sort="Nitkin, Ralph" uniqKey="Nitkin R" first="Ralph" last="Nitkin">Ralph Nitkin</name></author><author><name sortKey="Teasell, Robert" sort="Teasell, Robert" uniqKey="Teasell R" first="Robert" last="Teasell">Robert Teasell</name></author><author><name sortKey="Weiller, Cornelius" sort="Weiller, Cornelius" uniqKey="Weiller C" first="Cornelius" last="Weiller">Cornelius Weiller</name></author><author><name sortKey="Desai, Bhupat" sort="Desai, Bhupat" uniqKey="Desai B" first="Bhupat" last="Desai">Bhupat Desai</name></author><author><name sortKey="Goldberg, Mark P" sort="Goldberg, Mark P" uniqKey="Goldberg M" first="Mark P." last="Goldberg">Mark P. Goldberg</name></author><author><name sortKey="Heiss, Wolf Dieter" sort="Heiss, Wolf Dieter" uniqKey="Heiss W" first="Wolf-Dieter" last="Heiss">Wolf-Dieter Heiss</name></author><author><name sortKey="Saarelma, Osmo" sort="Saarelma, Osmo" uniqKey="Saarelma O" first="Osmo" last="Saarelma">Osmo Saarelma</name></author><author><name sortKey="Schwamm, Lee H" sort="Schwamm, Lee H" uniqKey="Schwamm L" first="Lee H." last="Schwamm">Lee H. Schwamm</name></author><author><name sortKey="Shinohara, Yukito" sort="Shinohara, Yukito" uniqKey="Shinohara Y" first="Yukito" last="Shinohara">Yukito Shinohara</name></author><author><name sortKey="Trivedi, Bhargava" sort="Trivedi, Bhargava" uniqKey="Trivedi B" first="Bhargava" last="Trivedi">Bhargava Trivedi</name></author><author><name sortKey="Wahlgren, Nils" sort="Wahlgren, Nils" uniqKey="Wahlgren N" first="Nils" last="Wahlgren">Nils Wahlgren</name></author><author><name sortKey="Wong, Lawrence K" sort="Wong, Lawrence K" uniqKey="Wong L" first="Lawrence K." last="Wong">Lawrence K. Wong</name></author><author><name sortKey="Hakim, Antoine" sort="Hakim, Antoine" uniqKey="Hakim A" first="Antoine" last="Hakim">Antoine Hakim</name></author><author><name sortKey="Norrving, Bo" sort="Norrving, Bo" uniqKey="Norrving B" first="Bo" last="Norrving">Bo Norrving</name></author><author><name sortKey="Prudhomme, Stephen" sort="Prudhomme, Stephen" uniqKey="Prudhomme S" first="Stephen" last="Prudhomme">Stephen Prudhomme</name></author><author><name sortKey="Bornstein, Natan M" sort="Bornstein, Natan M" uniqKey="Bornstein N" first="Natan M." last="Bornstein">Natan M. Bornstein</name></author><author><name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M." last="Davis">Stephen M. Davis</name></author><author><name sortKey="Goldstein, Larry B" sort="Goldstein, Larry B" uniqKey="Goldstein L" first="Larry B." last="Goldstein">Larry B. Goldstein</name></author><author><name sortKey="Leys, Didier" sort="Leys, Didier" uniqKey="Leys D" first="Didier" last="Leys">Didier Leys</name></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20516682</idno><idno type="pmc">3221270</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221270</idno><idno type="RBID">PMC:3221270</idno><idno type="doi">10.1159/000315099</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">001827</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001827</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Stroke: Working toward a Prioritized World Agenda</title><author><name sortKey="Hachinski, Vladimir" sort="Hachinski, Vladimir" uniqKey="Hachinski V" first="Vladimir" last="Hachinski">Vladimir Hachinski</name></author><author><name sortKey="Donnan, Geoffrey A" sort="Donnan, Geoffrey A" uniqKey="Donnan G" first="Geoffrey A." last="Donnan">Geoffrey A. Donnan</name></author><author><name sortKey="Gorelick, Philip B" sort="Gorelick, Philip B" uniqKey="Gorelick P" first="Philip B." last="Gorelick">Philip B. Gorelick</name></author><author><name sortKey="Hacke, Werner" sort="Hacke, Werner" uniqKey="Hacke W" first="Werner" last="Hacke">Werner Hacke</name></author><author><name sortKey="Cramer, Steven C" sort="Cramer, Steven C" uniqKey="Cramer S" first="Steven C." last="Cramer">Steven C. Cramer</name></author><author><name sortKey="Kaste, Markku" sort="Kaste, Markku" uniqKey="Kaste M" first="Markku" last="Kaste">Markku Kaste</name></author><author><name sortKey="Fisher, Marc" sort="Fisher, Marc" uniqKey="Fisher M" first="Marc" last="Fisher">Marc Fisher</name></author><author><name sortKey="Brainin, Michael" sort="Brainin, Michael" uniqKey="Brainin M" first="Michael" last="Brainin">Michael Brainin</name></author><author><name sortKey="Buchan, Alastair M" sort="Buchan, Alastair M" uniqKey="Buchan A" first="Alastair M." last="Buchan">Alastair M. Buchan</name></author><author><name sortKey="Lo, Eng H" sort="Lo, Eng H" uniqKey="Lo E" first="Eng H." last="Lo">Eng H. Lo</name></author><author><name sortKey="Skolnick, Brett E" sort="Skolnick, Brett E" uniqKey="Skolnick B" first="Brett E." last="Skolnick">Brett E. Skolnick</name></author><author><name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L." last="Furie">Karen L. Furie</name></author><author><name sortKey="Hankey, Graeme J" sort="Hankey, Graeme J" uniqKey="Hankey G" first="Graeme J." last="Hankey">Graeme J. Hankey</name></author><author><name sortKey="Kivipelto, Miia" sort="Kivipelto, Miia" uniqKey="Kivipelto M" first="Miia" last="Kivipelto">Miia Kivipelto</name></author><author><name sortKey="Morris, John" sort="Morris, John" uniqKey="Morris J" first="John" last="Morris">John Morris</name></author><author><name sortKey="Rothwell, Peter M" sort="Rothwell, Peter M" uniqKey="Rothwell P" first="Peter M." last="Rothwell">Peter M. Rothwell</name></author><author><name sortKey="Sacco, Ralph L" sort="Sacco, Ralph L" uniqKey="Sacco R" first="Ralph L." last="Sacco">Ralph L. Sacco</name></author><author><name sortKey="Smith Jr, Sidney C" sort="Smith Jr, Sidney C" uniqKey="Smith Jr S" first="Sidney C." last="Smith Jr.">Sidney C. Smith Jr.</name></author><author><name sortKey="Wang, Yulun" sort="Wang, Yulun" uniqKey="Wang Y" first="Yulun" last="Wang">Yulun Wang</name></author><author><name sortKey="Bryer, Alan" sort="Bryer, Alan" uniqKey="Bryer A" first="Alan" last="Bryer">Alan Bryer</name></author><author><name sortKey="Ford, Gary A" sort="Ford, Gary A" uniqKey="Ford G" first="Gary A." last="Ford">Gary A. Ford</name></author><author><name sortKey="Iadecola, Costantino" sort="Iadecola, Costantino" uniqKey="Iadecola C" first="Costantino" last="Iadecola">Costantino Iadecola</name></author><author><name sortKey="Martins, Sheila C O" sort="Martins, Sheila C O" uniqKey="Martins S" first="Sheila C. O." last="Martins">Sheila C. O. Martins</name></author><author><name sortKey="Saver, Jeff" sort="Saver, Jeff" uniqKey="Saver J" first="Jeff" last="Saver">Jeff Saver</name></author><author><name sortKey="Skvortsova, Veronika" sort="Skvortsova, Veronika" uniqKey="Skvortsova V" first="Veronika" last="Skvortsova">Veronika Skvortsova</name></author><author><name sortKey="Bayley, Mark" sort="Bayley, Mark" uniqKey="Bayley M" first="Mark" last="Bayley">Mark Bayley</name></author><author><name sortKey="Bednar, Martin M" sort="Bednar, Martin M" uniqKey="Bednar M" first="Martin M." last="Bednar">Martin M. Bednar</name></author><author><name sortKey="Duncan, Pamela" sort="Duncan, Pamela" uniqKey="Duncan P" first="Pamela" last="Duncan">Pamela Duncan</name></author><author><name sortKey="Enney, Lori" sort="Enney, Lori" uniqKey="Enney L" first="Lori" last="Enney">Lori Enney</name></author><author><name sortKey="Finklestein, Seth" sort="Finklestein, Seth" uniqKey="Finklestein S" first="Seth" last="Finklestein">Seth Finklestein</name></author><author><name sortKey="Jones, Theresa A" sort="Jones, Theresa A" uniqKey="Jones T" first="Theresa A." last="Jones">Theresa A. Jones</name></author><author><name sortKey="Kalra, Lalit" sort="Kalra, Lalit" uniqKey="Kalra L" first="Lalit" last="Kalra">Lalit Kalra</name></author><author><name sortKey="Kleim, Jeff" sort="Kleim, Jeff" uniqKey="Kleim J" first="Jeff" last="Kleim">Jeff Kleim</name></author><author><name sortKey="Nitkin, Ralph" sort="Nitkin, Ralph" uniqKey="Nitkin R" first="Ralph" last="Nitkin">Ralph Nitkin</name></author><author><name sortKey="Teasell, Robert" sort="Teasell, Robert" uniqKey="Teasell R" first="Robert" last="Teasell">Robert Teasell</name></author><author><name sortKey="Weiller, Cornelius" sort="Weiller, Cornelius" uniqKey="Weiller C" first="Cornelius" last="Weiller">Cornelius Weiller</name></author><author><name sortKey="Desai, Bhupat" sort="Desai, Bhupat" uniqKey="Desai B" first="Bhupat" last="Desai">Bhupat Desai</name></author><author><name sortKey="Goldberg, Mark P" sort="Goldberg, Mark P" uniqKey="Goldberg M" first="Mark P." last="Goldberg">Mark P. Goldberg</name></author><author><name sortKey="Heiss, Wolf Dieter" sort="Heiss, Wolf Dieter" uniqKey="Heiss W" first="Wolf-Dieter" last="Heiss">Wolf-Dieter Heiss</name></author><author><name sortKey="Saarelma, Osmo" sort="Saarelma, Osmo" uniqKey="Saarelma O" first="Osmo" last="Saarelma">Osmo Saarelma</name></author><author><name sortKey="Schwamm, Lee H" sort="Schwamm, Lee H" uniqKey="Schwamm L" first="Lee H." last="Schwamm">Lee H. Schwamm</name></author><author><name sortKey="Shinohara, Yukito" sort="Shinohara, Yukito" uniqKey="Shinohara Y" first="Yukito" last="Shinohara">Yukito Shinohara</name></author><author><name sortKey="Trivedi, Bhargava" sort="Trivedi, Bhargava" uniqKey="Trivedi B" first="Bhargava" last="Trivedi">Bhargava Trivedi</name></author><author><name sortKey="Wahlgren, Nils" sort="Wahlgren, Nils" uniqKey="Wahlgren N" first="Nils" last="Wahlgren">Nils Wahlgren</name></author><author><name sortKey="Wong, Lawrence K" sort="Wong, Lawrence K" uniqKey="Wong L" first="Lawrence K." last="Wong">Lawrence K. Wong</name></author><author><name sortKey="Hakim, Antoine" sort="Hakim, Antoine" uniqKey="Hakim A" first="Antoine" last="Hakim">Antoine Hakim</name></author><author><name sortKey="Norrving, Bo" sort="Norrving, Bo" uniqKey="Norrving B" first="Bo" last="Norrving">Bo Norrving</name></author><author><name sortKey="Prudhomme, Stephen" sort="Prudhomme, Stephen" uniqKey="Prudhomme S" first="Stephen" last="Prudhomme">Stephen Prudhomme</name></author><author><name sortKey="Bornstein, Natan M" sort="Bornstein, Natan M" uniqKey="Bornstein N" first="Natan M." last="Bornstein">Natan M. Bornstein</name></author><author><name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M." last="Davis">Stephen M. Davis</name></author><author><name sortKey="Goldstein, Larry B" sort="Goldstein, Larry B" uniqKey="Goldstein L" first="Larry B." last="Goldstein">Larry B. Goldstein</name></author><author><name sortKey="Leys, Didier" sort="Leys, Didier" uniqKey="Leys D" first="Didier" last="Leys">Didier Leys</name></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name></author></analytic><series><title level="j">Cerebrovascular Diseases (Basel, Switzerland)</title><idno type="ISSN">1015-9770</idno><idno type="eISSN">1421-9786</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background and Purpose</title><p>The aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke.</p></sec><sec><title>Methods</title><p>Preliminary work was performed by 7 working groups of stroke leaders followed by a synergium (a forum for working synergistically together) with approximately 100 additional participants. The resulting draft document had further input from contributors outside the synergium.</p></sec><sec><title>Results</title><p>Recommendations of the Synergium are: <italic>Basic Science, Drug Development and Technology:</italic> There is a need to develop: (1) New systems of working together to break down the prevalent ‘silo’ mentality; (2) New models of vertically integrated basic, clinical, and epidemiological disciplines; and (3) Efficient methods of identifying other relevant areas of science. <italic>Stroke Prevention:</italic> (1) Establish a global chronic disease prevention initiative with stroke as a major focus. (2) Recognize not only abrupt clinical stroke, but subtle subclinical stroke, the commonest type of cerebrovascular disease, leading to impairments of executive function. (3) Develop, implement and evaluate a population approach for stroke prevention. (4) Develop public health communication strategies using traditional and novel (e.g., social media/marketing) techniques. <italic>Acute Stroke Management:</italic> Continue the establishment of stroke centers, stroke units, regional systems of emergency stroke care and telestroke networks. <italic>Brain Recovery and Rehabilitation:</italic> (1) Translate best neuroscience, including animal and human studies, into poststroke recovery research and clinical care. (2) Standardize poststroke rehabilitation based on best evidence. (3) Develop consensus on, then implementation of, standardized clinical and surrogate assessments. (4) Carry out rigorous clinical research to advance stroke recovery. <italic>Into the 21st Century: Web, Technology and Communications:</italic> (1) Work toward global unrestricted access to stroke-related information. (2) Build centralized electronic archives and registries. <italic>Foster Cooperation Among Stakeholders</italic> (large stroke organizations, nongovernmental organizations, governments, patient organizations and industry) to enhance stroke care. <italic>Educate and energize professionals, patients, the public and policy makers</italic> by using a ‘Brain Health’ concept that enables promotion of preventive measures.</p></sec><sec><title>Conclusions</title><p>To accelerate progress in stroke, we must reach beyond the current status scientifically, conceptually, and pragmatically. Advances can be made not only by doing, but ceasing to do. Significant savings in time, money, and effort could result from discontinuing practices driven by unsubstantiated opinion, unproven approaches, and financial gain. Systematic integration of knowledge into programs coupled with careful evaluation can speed the pace of progress.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cerebrovasc Dis</journal-id><journal-id journal-id-type="publisher-id">CED</journal-id><journal-title-group><journal-title>Cerebrovascular Diseases (Basel, Switzerland)</journal-title></journal-title-group><issn pub-type="ppub">1015-9770</issn><issn pub-type="epub">1421-9786</issn><publisher><publisher-name>S. Karger AG</publisher-name><publisher-loc>Allschwilerstrasse 10, P.O. Box · Postfach · Case postale, CH–4009, Basel, Switzerland · Schweiz · Suisse, Phone: +41 61 306 11 11, Fax: +41 61 306 12 34, karger@karger.ch</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20516682</article-id><article-id pub-id-type="pmc">3221270</article-id><article-id pub-id-type="doi">10.1159/000315099</article-id><article-id pub-id-type="publisher-id">ced0030-0127</article-id><article-categories><subj-group subj-group-type="heading"><subject><italic>Stroke</italic> Turns 40</subject></subj-group></article-categories><title-group><article-title>Stroke: Working toward a Prioritized World Agenda</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Hachinski</surname><given-names>Vladimir</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Donnan</surname><given-names>Geoffrey A.</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref><xref ref-type="aff" rid="aff1a"><sup>a</sup></xref><xref ref-type="aff" rid="aff1h"><sup>h</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gorelick</surname><given-names>Philip B.</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref><xref ref-type="aff" rid="aff1b"><sup>b</sup></xref><xref ref-type="aff" rid="aff1h"><sup>h</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hacke</surname><given-names>Werner</given-names></name><xref ref-type="aff" rid="aff30"><sup>30</sup></xref><xref ref-type="aff" rid="aff1c"><sup>c</sup></xref><xref ref-type="aff" rid="aff1h"><sup>h</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cramer</surname><given-names>Steven C.</given-names></name><xref ref-type="aff" rid="aff10"><sup>10</sup></xref><xref ref-type="aff" rid="aff1d"><sup>d</sup></xref><xref ref-type="aff" rid="aff1h"><sup>h</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kaste</surname><given-names>Markku</given-names></name><xref ref-type="aff" rid="aff33"><sup>33</sup></xref><xref ref-type="aff" rid="aff1e"><sup>e</sup></xref><xref ref-type="aff" rid="aff1h"><sup>h</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fisher</surname><given-names>Marc</given-names></name><xref ref-type="aff" rid="aff14"><sup>14</sup></xref><xref ref-type="aff" rid="aff1f"><sup>f</sup></xref><xref ref-type="aff" rid="aff1h"><sup>h</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brainin</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="aff36"><sup>36</sup></xref><xref ref-type="aff" rid="aff1g"><sup>g</sup></xref><xref ref-type="aff" rid="aff1h"><sup>h</sup></xref></contrib><contrib contrib-type="author"><name><surname>Buchan</surname><given-names>Alastair M.</given-names></name><xref ref-type="aff" rid="aff37"><sup>37</sup></xref><xref ref-type="aff" rid="aff1a"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lo</surname><given-names>Eng H.</given-names></name><xref ref-type="aff" rid="aff15"><sup>15</sup></xref><xref ref-type="aff" rid="aff1a"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Skolnick</surname><given-names>Brett E.</given-names></name><xref ref-type="aff" rid="aff17"><sup>17</sup></xref><xref ref-type="aff" rid="aff1a"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Furie</surname><given-names>Karen L.</given-names></name><xref ref-type="aff" rid="aff15"><sup>15</sup></xref><xref ref-type="aff" rid="aff1b"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hankey</surname><given-names>Graeme J.</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref><xref ref-type="aff" rid="aff1b"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kivipelto</surname><given-names>Miia</given-names></name><xref ref-type="aff" rid="aff41"><sup>41</sup></xref><xref ref-type="aff" rid="aff1b"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Morris</surname><given-names>John</given-names></name><xref ref-type="aff" rid="aff18"><sup>18</sup></xref><xref ref-type="aff" rid="aff1b"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rothwell</surname><given-names>Peter M.</given-names></name><xref ref-type="aff" rid="aff38"><sup>38</sup></xref><xref ref-type="aff" rid="aff1b"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sacco</surname><given-names>Ralph L.</given-names></name><xref ref-type="aff" rid="aff19"><sup>19</sup></xref><xref ref-type="aff" rid="aff1b"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Smith, Jr.</surname><given-names>Sidney C.</given-names></name><xref ref-type="aff" rid="aff21"><sup>21</sup></xref><xref ref-type="aff" rid="aff43"><sup>43</sup></xref><xref ref-type="aff" rid="aff1b"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Yulun</given-names></name><xref ref-type="aff" rid="aff12"><sup>12</sup></xref><xref ref-type="aff" rid="aff1b"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bryer</surname><given-names>Alan</given-names></name><xref ref-type="aff" rid="aff44"><sup>44</sup></xref><xref ref-type="aff" rid="aff1c"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ford</surname><given-names>Gary A.</given-names></name><xref ref-type="aff" rid="aff39"><sup>39</sup></xref><xref ref-type="aff" rid="aff1c"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Iadecola</surname><given-names>Costantino</given-names></name><xref ref-type="aff" rid="aff25"><sup>25</sup></xref><xref ref-type="aff" rid="aff1c"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Martins</surname><given-names>Sheila C.O.</given-names></name><xref ref-type="aff" rid="aff45"><sup>45</sup></xref><xref ref-type="aff" rid="aff1c"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Saver</surname><given-names>Jeff</given-names></name><xref ref-type="aff" rid="aff13"><sup>13</sup></xref><xref ref-type="aff" rid="aff1c"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Skvortsova</surname><given-names>Veronika</given-names></name><xref ref-type="aff" rid="aff46"><sup>46</sup></xref><xref ref-type="aff" rid="aff1c"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bayley</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="aff" rid="aff1d"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bednar</surname><given-names>Martin M.</given-names></name><xref ref-type="aff" rid="aff26"><sup>26</sup></xref><xref ref-type="aff" rid="aff1d"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Duncan</surname><given-names>Pamela</given-names></name><xref ref-type="aff" rid="aff22"><sup>22</sup></xref><xref ref-type="aff" rid="aff1d"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Enney</surname><given-names>Lori</given-names></name><xref ref-type="aff" rid="aff23"><sup>23</sup></xref><xref ref-type="aff" rid="aff1d"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Finklestein</surname><given-names>Seth</given-names></name><xref ref-type="aff" rid="aff16"><sup>16</sup></xref><xref ref-type="aff" rid="aff1d"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jones</surname><given-names>Theresa A.</given-names></name><xref ref-type="aff" rid="aff27"><sup>27</sup></xref><xref ref-type="aff" rid="aff1d"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kalra</surname><given-names>Lalit</given-names></name><xref ref-type="aff" rid="aff40"><sup>40</sup></xref><xref ref-type="aff" rid="aff1d"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kleim</surname><given-names>Jeff</given-names></name><xref ref-type="aff" rid="aff20"><sup>20</sup></xref><xref ref-type="aff" rid="aff1d"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nitkin</surname><given-names>Ralph</given-names></name><xref ref-type="aff" rid="aff28"><sup>28</sup></xref><xref ref-type="aff" rid="aff1d"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Teasell</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff1d"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Weiller</surname><given-names>Cornelius</given-names></name><xref ref-type="aff" rid="aff31"><sup>31</sup></xref><xref ref-type="aff" rid="aff1d"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Desai</surname><given-names>Bhupat</given-names></name><xref ref-type="aff" rid="aff11"><sup>11</sup></xref><xref ref-type="aff" rid="aff1e"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Goldberg</surname><given-names>Mark P.</given-names></name><xref ref-type="aff" rid="aff18"><sup>18</sup></xref><xref ref-type="aff" rid="aff1e"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Heiss</surname><given-names>Wolf-Dieter</given-names></name><xref ref-type="aff" rid="aff32"><sup>32</sup></xref><xref ref-type="aff" rid="aff1e"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Saarelma</surname><given-names>Osmo</given-names></name><xref ref-type="aff" rid="aff34"><sup>34</sup></xref><xref ref-type="aff" rid="aff1e"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schwamm</surname><given-names>Lee H.</given-names></name><xref ref-type="aff" rid="aff15"><sup>15</sup></xref><xref ref-type="aff" rid="aff1e"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shinohara</surname><given-names>Yukito</given-names></name><xref ref-type="aff" rid="aff47"><sup>47</sup></xref><xref ref-type="aff" rid="aff1e"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Trivedi</surname><given-names>Bhargava</given-names></name><xref ref-type="aff" rid="aff9"><sup>9</sup></xref><xref ref-type="aff" rid="aff1e"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wahlgren</surname><given-names>Nils</given-names></name><xref ref-type="aff" rid="aff41"><sup>41</sup></xref><xref ref-type="aff" rid="aff1e"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wong</surname><given-names>Lawrence K.</given-names></name><xref ref-type="aff" rid="aff48"><sup>48</sup></xref><xref ref-type="aff" rid="aff1e"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hakim</surname><given-names>Antoine</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><xref ref-type="aff" rid="aff1f"><sup>f</sup></xref></contrib><contrib contrib-type="author"><name><surname>Norrving</surname><given-names>Bo</given-names></name><xref ref-type="aff" rid="aff42"><sup>42</sup></xref><xref ref-type="aff" rid="aff1f"><sup>f</sup></xref></contrib><contrib contrib-type="author"><name><surname>Prudhomme</surname><given-names>Stephen</given-names></name><xref ref-type="aff" rid="aff29"><sup>29</sup></xref><xref ref-type="aff" rid="aff1f"><sup>f</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bornstein</surname><given-names>Natan M.</given-names></name><xref ref-type="aff" rid="aff49"><sup>49</sup></xref><xref ref-type="aff" rid="aff1g"><sup>g</sup></xref></contrib><contrib contrib-type="author"><name><surname>Davis</surname><given-names>Stephen M.</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref><xref ref-type="aff" rid="aff1g"><sup>g</sup></xref></contrib><contrib contrib-type="author"><name><surname>Goldstein</surname><given-names>Larry B.</given-names></name><xref ref-type="aff" rid="aff24"><sup>24</sup></xref><xref ref-type="aff" rid="aff1g"><sup>g</sup></xref></contrib><contrib contrib-type="author"><name><surname>Leys</surname><given-names>Didier</given-names></name><xref ref-type="aff" rid="aff50"><sup>50</sup></xref><xref ref-type="aff" rid="aff1g"><sup>g</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tuomilehto</surname><given-names>Jaakko</given-names></name><xref ref-type="aff" rid="aff35"><sup>35</sup></xref><xref ref-type="aff" rid="aff1g"><sup>g</sup></xref></contrib></contrib-group><aff>Working Groups:</aff><aff id="aff1a"><sup>a</sup>Basic Science, Drug Development, and Technology</aff><aff id="aff1b"><sup>b</sup>Stroke Prevention: Broadening the Approach and Intensifying the Efforts</aff><aff id="aff1c"><sup>c</sup>Acute Stroke Management: Applying and Expanding What We Know</aff><aff id="aff1d"><sup>d</sup>Brain Recovery and Rehabilitation: Harnessing the Regenerative Powers of the Brain and the Individual</aff><aff id="aff1e"><sup>e</sup>Into the 21st Century: The Web, Technology, and Communications: New Tools for Progress</aff><aff id="aff1f"><sup>f</sup>Fostering Cooperation Among Stakeholders to Enhance Stroke Care</aff><aff id="aff1g"><sup>g</sup>Educating and Energizing Professionals, Patients, the Public, and Policymakers.</aff><aff id="aff1h"><sup>h</sup>The coordinator of each group. The work of the coordinators is deemed to have been equal. The other authors are listed according to the sequence of their groups and alphabetically, and their work is also deemed to be equal to each other's.</aff><aff id="aff1"><sup>1</sup> Department of Clinical Neurological Sciences, London Health Sciences Center, University of Western Ontario, Ont., Canada</aff><aff id="aff2"><sup>2</sup> St. Joseph's Healthcare London, London, Ont., Canada</aff><aff id="aff3"><sup>3</sup> Toronto Rehabilitation Institute, Toronto, Ont., Canada</aff><aff id="aff4"><sup>4</sup> The Canadian Stroke Network, The University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Ont., Canada</aff><aff id="aff5"><sup>5</sup> Florey Neurosciences Institutes, Carlton South Victoria, Vic., Australia</aff><aff id="aff6"><sup>6</sup> Director of Neurology, Royal Melbourne Hospital and University of Melbourne, Melbourne, Vic., Australia</aff><aff id="aff7"><sup>7</sup> Royal Perth Hospital, Perth, W.A., Australia</aff><aff id="aff8"><sup>8</sup> University of Illinois at Chicago, Chicago, Ill., USA</aff><aff id="aff9"><sup>9</sup> Southern Illinois Healthcare, Carbondale, Ill., USA</aff><aff id="aff10"><sup>10</sup> University of California – Irvine, Orange, Calif., USA</aff><aff id="aff11"><sup>11</sup> Pomona Valley Hospital Medical Center, Pomona, Calif., USA</aff><aff id="aff12"><sup>12</sup> InTouch Health, Goleta, Calif., USA</aff><aff id="aff13"><sup>13</sup> University of California at Los Angeles Stroke Center, Los Angeles, Calif., USA</aff><aff id="aff14"><sup>14</sup> University of Massachusetts Medical School, Worcester, Mass., USA</aff><aff id="aff15"><sup>15</sup> Massachusetts General Hospital, Charlestown, Mass., USA</aff><aff id="aff16"><sup>16</sup> Biotrofix, Inc., Waltham, Mass., USA</aff><aff id="aff17"><sup>17</sup> Novo Nordisk, Princeton, N.J., USA</aff><aff id="aff18"><sup>18</sup> Washington University School of Medicine, St. Louis, Mo., USA</aff><aff id="aff19"><sup>19</sup> President-elect, AHA, University of Miami, Miami, Fla., USA</aff><aff id="aff20"><sup>20</sup> University of Florida, Gainesville, Fla., USA</aff><aff id="aff21"><sup>21</sup> Center for Cardiovascular Science and Medicine, University of North Carolina, Chapel Hill, N.C., USA</aff><aff id="aff22"><sup>22</sup> Duke University, Durham, N.C., USA</aff><aff id="aff23"><sup>23</sup> GlaxoSmithKline, Durham, N.C., USA</aff><aff id="aff24"><sup>24</sup> Duke University and Durham VA Medical Center, Durham, N.C., USA</aff><aff id="aff25"><sup>25</sup> Weill Cornell Medical College, New York, N.Y., USA</aff><aff id="aff26"><sup>26</sup> Neuroscience Research Unit, Pfizer Inc., Groton, Conn., USA</aff><aff id="aff27"><sup>27</sup> University of Texas at Austin, Austin, Tex., USA</aff><aff id="aff28"><sup>28</sup> National Center for Medical Rehabilitation, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Md., USA</aff><aff id="aff29"><sup>29</sup> American Heart Association, Dallas, Tex., USA</aff><aff id="aff30"><sup>30</sup> University of Heidelberg, Heidelberg, Germany</aff><aff id="aff31"><sup>31</sup> University of Freiburg, Freiburg, Germany</aff><aff id="aff32"><sup>32</sup> Max Planck Institute for Neurological Research, Köln, Germany</aff><aff id="aff33"><sup>33</sup> Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</aff><aff id="aff34"><sup>34</sup> Terveystalo Medical Center, Helsinki, Finland</aff><aff id="aff35"><sup>35</sup> University of Helsinki, Helsinki, Finland</aff><aff id="aff36"><sup>36</sup> University Donau-Universität Krems, Krems, Austria</aff><aff id="aff37"><sup>37</sup> University of Oxford, Oxford, UK</aff><aff id="aff38"><sup>38</sup> John Radcliffe Hospital, Oxford, UK</aff><aff id="aff39"><sup>39</sup> Newcastle University, Newcastle upon Tyne, London, UK</aff><aff id="aff40"><sup>40</sup> Kings College London, London, UK</aff><aff id="aff41"><sup>41</sup> Karolinska Institute, Stockholm, Sweden</aff><aff id="aff42"><sup>42</sup> Lund University Hospital, Lund, Sweden</aff><aff id="aff43"><sup>43</sup> President-elect, World Heart Federation, Geneva, Switzerland</aff><aff id="aff44"><sup>44</sup> Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa</aff><aff id="aff45"><sup>45</sup> Hospital De Clinicas, Porto Alegre, Brazil</aff><aff id="aff46"><sup>46</sup> Russian State Research Stroke Institute, Moscow, Russian Federation</aff><aff id="aff47"><sup>47</sup> Tachikawa Hospital, Tokyo, Japan</aff><aff id="aff48"><sup>48</sup> Chinese University of Hong Kong, Sha Tin, Hong Kong, China</aff><aff id="aff49"><sup>49</sup> Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel</aff><aff id="aff50"><sup>50</sup> University Lille Nord de France, Lille, France</aff><author-notes><corresp id="cor1">*Vladimir Hachinski, MD, FRCPC, DSc, University of Western Ontario, University Hospital, 339 Windermere Road, London, Ont. N6A 5A5 (Canada), E-Mail <email>Vladimir.Hachinski@lhsc.on.ca</email></corresp></author-notes><pub-date pub-type="ppub"><month>7</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>24</day><month>5</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>7</month><year>2011</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>30</volume><issue>2</issue><fpage>127</fpage><lpage>147</lpage><permissions><copyright-statement>Copyright © 2010 by American Heart Association. Inc., S. Karger AG, Basel, and John Wiley & Sons, Inc.</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><sec><title>Background and Purpose</title><p>The aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke.</p></sec><sec><title>Methods</title><p>Preliminary work was performed by 7 working groups of stroke leaders followed by a synergium (a forum for working synergistically together) with approximately 100 additional participants. The resulting draft document had further input from contributors outside the synergium.</p></sec><sec><title>Results</title><p>Recommendations of the Synergium are: <italic>Basic Science, Drug Development and Technology:</italic> There is a need to develop: (1) New systems of working together to break down the prevalent ‘silo’ mentality; (2) New models of vertically integrated basic, clinical, and epidemiological disciplines; and (3) Efficient methods of identifying other relevant areas of science. <italic>Stroke Prevention:</italic> (1) Establish a global chronic disease prevention initiative with stroke as a major focus. (2) Recognize not only abrupt clinical stroke, but subtle subclinical stroke, the commonest type of cerebrovascular disease, leading to impairments of executive function. (3) Develop, implement and evaluate a population approach for stroke prevention. (4) Develop public health communication strategies using traditional and novel (e.g., social media/marketing) techniques. <italic>Acute Stroke Management:</italic> Continue the establishment of stroke centers, stroke units, regional systems of emergency stroke care and telestroke networks. <italic>Brain Recovery and Rehabilitation:</italic> (1) Translate best neuroscience, including animal and human studies, into poststroke recovery research and clinical care. (2) Standardize poststroke rehabilitation based on best evidence. (3) Develop consensus on, then implementation of, standardized clinical and surrogate assessments. (4) Carry out rigorous clinical research to advance stroke recovery. <italic>Into the 21st Century: Web, Technology and Communications:</italic> (1) Work toward global unrestricted access to stroke-related information. (2) Build centralized electronic archives and registries. <italic>Foster Cooperation Among Stakeholders</italic> (large stroke organizations, nongovernmental organizations, governments, patient organizations and industry) to enhance stroke care. <italic>Educate and energize professionals, patients, the public and policy makers</italic> by using a ‘Brain Health’ concept that enables promotion of preventive measures.</p></sec><sec><title>Conclusions</title><p>To accelerate progress in stroke, we must reach beyond the current status scientifically, conceptually, and pragmatically. Advances can be made not only by doing, but ceasing to do. Significant savings in time, money, and effort could result from discontinuing practices driven by unsubstantiated opinion, unproven approaches, and financial gain. Systematic integration of knowledge into programs coupled with careful evaluation can speed the pace of progress.</p></sec></abstract><kwd-group><title>Key Words</title><kwd>Prevention</kwd><kwd>Rehabilitation</kwd><kwd>Stroke</kwd><kwd>Translational</kwd><kwd>Treatment</kwd></kwd-group><counts><fig-count count="1"></fig-count><ref-count count="93"></ref-count><page-count count="21"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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