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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer</title><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation><nlm:aff id="AF0001"><institution>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Lorenzo Bermejo, Justo" sort="Lorenzo Bermejo, Justo" uniqKey="Lorenzo Bermejo J" first="Justo" last="Lorenzo Bermejo">Justo Lorenzo Bermejo</name><affiliation><nlm:aff id="AF0002"><institution>Institute of Medical Biometry and Informatics, University Hospital Heidelberg</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Dunnebier, Thomas" sort="Dunnebier, Thomas" uniqKey="Dunnebier T" first="Thomas" last="Dünnebier">Thomas Dünnebier</name><affiliation><nlm:aff id="AF0001"><institution>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Ying, Shibo" sort="Ying, Shibo" uniqKey="Ying S" first="Shibo" last="Ying">Shibo Ying</name><affiliation><nlm:aff id="AF0001"><institution>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff wicri:cut=" and" id="AF0003"><institution>Department of Public Health and Primary Care</institution></nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff wicri:cut=" and" id="AF0003"><institution>Department of Public Health and Primary Care</institution></nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff wicri:cut=" and" id="AF0003"><institution>Department of Public Health and Primary Care</institution></nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff wicri:cut=" and" id="AF0003"><institution>Department of Public Health and Primary Care</institution></nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="AF0004"><institution>Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>,<addr-line>Cambridge, CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Perkins, Barbara J" sort="Perkins, Barbara J" uniqKey="Perkins B" first="Barbara J." last="Perkins">Barbara J. Perkins</name><affiliation><nlm:aff id="AF0004"><institution>Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>,<addr-line>Cambridge, CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="AF0005"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm, SE-17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="AF0005"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm, SE-17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name><affiliation><nlm:aff id="AF0005"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm, SE-17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="AF0006"><institution>Copenhagen General Population Study</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="AF0007"><institution>Department of Clinical Biochemistry</institution></nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="AF0006"><institution>Copenhagen General Population Study</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="AF0007"><institution>Department of Clinical Biochemistry</institution></nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="AF0006"><institution>Copenhagen General Population Study</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="AF0007"><institution>Department of Clinical Biochemistry</institution></nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="AF0008"><institution>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital</institution>,<addr-line>2730 Herlev</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="AF0009"><institution>Vesalius Research Center, VIB</institution>,<addr-line>3000 Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0010"><institution>Department of Oncology, Laboratory for Translational Genetics, University of Leuven</institution>,<addr-line>3000 Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation></author><author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name><affiliation><nlm:aff id="AF0011"><institution>Department of Oncology, KU Leuven (University of Leuven), Multidisciplinary Breast Center, University Hospitals Leuven</institution>,<addr-line>3000 Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation></author><author><name sortKey="Peeters, Stephanie" sort="Peeters, Stephanie" uniqKey="Peeters S" first="Stephanie" last="Peeters">Stephanie Peeters</name><affiliation><nlm:aff id="AF0011"><institution>Department of Oncology, KU Leuven (University of Leuven), Multidisciplinary Breast Center, University Hospitals Leuven</institution>,<addr-line>3000 Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation></author><author><name sortKey="Weltens, Caroline" sort="Weltens, Caroline" uniqKey="Weltens C" first="Caroline" last="Weltens">Caroline Weltens</name><affiliation><nlm:aff id="AF0011"><institution>Department of Oncology, KU Leuven (University of Leuven), Multidisciplinary Breast Center, University Hospitals Leuven</institution>,<addr-line>3000 Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff wicri:cut=" and" id="AF0012"><institution>Department of Laboratory Medicine and Pathology</institution></nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="AF0013"><institution>Department of Health Sciences Research, Mayo Clinic</institution>,<addr-line>Rochester, MN 55905</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff wicri:cut=" and" id="AF0012"><institution>Department of Laboratory Medicine and Pathology</institution></nlm:aff></affiliation></author><author><name sortKey="Purrington, Kristen" sort="Purrington, Kristen" uniqKey="Purrington K" first="Kristen" last="Purrington">Kristen Purrington</name><affiliation><nlm:aff id="AF0014"><institution>Karmanos Cancer Institute</institution>,<addr-line>Detroit, MI 48201</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="AF0015"><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="AF0015"><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Seibold, Petra" sort="Seibold, Petra" uniqKey="Seibold P" first="Petra" last="Seibold">Petra Seibold</name><affiliation><nlm:aff id="AF0015"><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="AF0016"><institution>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf</institution>,<addr-line>20246 Hamburg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="AF0017"><institution>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine</institution>,<country>London</country>,<addr-line>WC1E 7HT</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:aff id="AF0017"><institution>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine</institution>,<country>London</country>,<addr-line>WC1E 7HT</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="AF0018"><institution>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research</institution>,<addr-line>London, SW3 6JB</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="AF0018"><institution>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research</institution>,<addr-line>London, SW3 6JB</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="AF0019"><institution>Department of Obstetrics and Gynecology</institution>,</nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="AF0019"><institution>Department of Obstetrics and Gynecology</institution>,</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff wicri:cut=" and" id="AF0020"><institution>Department of Clinical Genetics</institution></nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="AF0021"><institution>Department of Oncology, University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>FI-00029 Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="AF0022"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>1066 CX Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="AF0022"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>1066 CX Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Cornelissen, Sten" sort="Cornelissen, Sten" uniqKey="Cornelissen S" first="Sten" last="Cornelissen">Sten Cornelissen</name><affiliation><nlm:aff id="AF0022"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>1066 CX Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name><affiliation><nlm:aff id="AF0022"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>1066 CX Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="AF0023"><institution>Human Genetics Division, Genome Institute of Singapore</institution>,<addr-line>Singapore 138672</addr-line>,<country>Singapore</country>,</nlm:aff></affiliation></author><author><name sortKey="Brand, Judith S" sort="Brand, Judith S" uniqKey="Brand J" first="Judith S." last="Brand">Judith S. Brand</name><affiliation><nlm:aff id="AF0005"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm, SE-17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="AF0005"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm, SE-17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="AF0024"><institution>National Institute of Health and Medical Research, Center for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0025"><institution>University Paris-Sud</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="AF0024"><institution>National Institute of Health and Medical Research, Center for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0025"><institution>University Paris-Sud</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation><nlm:aff id="AF0024"><institution>National Institute of Health and Medical Research, Center for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0025"><institution>University Paris-Sud</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Sanchez, Marie" sort="Sanchez, Marie" uniqKey="Sanchez M" first="Marie" last="Sanchez">Marie Sanchez</name><affiliation><nlm:aff id="AF0024"><institution>National Institute of Health and Medical Research, Center for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0025"><institution>University Paris-Sud</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="AF0026"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0027"><institution>Molecular Epidemiology Group, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marmé">Frederik Marmé</name><affiliation><nlm:aff id="AF0026"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0028"><institution>National Center for Tumor Diseases, University of Heidelberg</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Yang, Rongxi" sort="Yang, Rongxi" uniqKey="Yang R" first="Rongxi" last="Yang">Rongxi Yang</name><affiliation><nlm:aff id="AF0026"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0027"><institution>Molecular Epidemiology Group, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Bugert, Peter" sort="Bugert, Peter" uniqKey="Bugert P" first="Peter" last="Bugert">Peter Bugert</name><affiliation><nlm:aff id="AF0029"><institution>Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University</institution>,<addr-line>68167 Mannheim</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation><nlm:aff id="AF0030"><institution>Human Genotyping-CEGEN Unit</institution>and</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name></author><author><name sortKey="Pilar Zamora, M" sort="Pilar Zamora, M" uniqKey="Pilar Zamora M" first="M." last="Pilar Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="AF0033"><institution>Servicio de Oncología Médica, Hospital Universitario La Paz</institution>,<addr-line>28046 Madrid</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Arias Perez, Jose I" sort="Arias Perez, Jose I" uniqKey="Arias Perez J" first="Jose I." last="Arias Perez">Jose I. Arias Perez</name><affiliation><nlm:aff id="AF0034"><institution>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco</institution>,<addr-line>33012 Oviedo</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="AF0035"><institution>Department of Oncology, University of Sheffield</institution>,<addr-line>Sheffield, S10 2RX</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="AF0036"><institution>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield</institution>,<addr-line>Sheffield S10 2HQ</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="AF0035"><institution>Department of Oncology, University of Sheffield</institution>,<addr-line>Sheffield, S10 2RX</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="AF0037"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto, ON M5G 1X5</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0038"><institution>Department of Molecular Genetics, University of Toronto</institution>,<addr-line>Toronto, ON M5S 1A8</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="AF0039"><institution>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto, ON M5G 1X5</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0040"><institution>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto</institution>,<addr-line>Toronto, ON M5T 3M7</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="AF0041"><institution>ON Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto, ON, M5G 1X5</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name><affiliation><nlm:aff id="AF0037"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto, ON M5G 1X5</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="AF0042"><institution>Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital</institution>,<addr-line>London SE1 9RT</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="AF0043"><institution>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford</institution>,<addr-line>Oxford OX3 7BN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name><affiliation><nlm:aff id="AF0044"><institution>Clinical Science Institute, University Hospital Galway</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country>,</nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="AF0044"><institution>Clinical Science Institute, University Hospital Galway</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country>,</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="AF0047"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation><nlm:aff id="AF0047"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="AF0047"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="AF0048"><institution>Epidemiology Program, University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI 96813</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff wicri:cut=" and" id="AF0049"><institution>Department of Molecular Medicine and Surgery</institution></nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="AF0050"><institution>Department of Oncology - Pathology, Karolinska Institutet</institution>,<addr-line>Stockholm SE-17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff wicri:cut=" and" id="AF0051"><institution>Department of Medical Oncology</institution></nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff wicri:cut=" and" id="AF0051"><institution>Department of Medical Oncology</institution></nlm:aff></affiliation></author><author><name sortKey="Kriege, Mieke" sort="Kriege, Mieke" uniqKey="Kriege M" first="Mieke" last="Kriege">Mieke Kriege</name><affiliation><nlm:aff wicri:cut=" and" id="AF0051"><institution>Department of Medical Oncology</institution></nlm:aff></affiliation></author><author><name sortKey="Koppert, Linetta B" sort="Koppert, Linetta B" uniqKey="Koppert L" first="Linetta B." last="Koppert">Linetta B. Koppert</name><affiliation><nlm:aff id="AF0052"><institution>Department of Surgical Oncology, Erasmus MC Cancer Institute</institution>,<addr-line>3008 AE Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff wicri:cut=" and" id="AF0053"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</institution></nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="AF0054"><institution>Department of Pathology, The University of Melbourne</institution>,<addr-line>Melbourne, Victoria 3010</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation><nlm:aff id="AF0054"><institution>Department of Pathology, The University of Melbourne</institution>,<addr-line>Melbourne, Victoria 3010</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff wicri:cut=" and" id="AF0053"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</institution></nlm:aff></affiliation></author><author><name sortKey="Slettedahl, Seth" sort="Slettedahl, Seth" uniqKey="Slettedahl S" first="Seth" last="Slettedahl">Seth Slettedahl</name><affiliation><nlm:aff id="AF0013"><institution>Department of Health Sciences Research, Mayo Clinic</institution>,<addr-line>Rochester, MN 55905</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="AF0055"><institution>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University</institution>,<addr-line>Columbus, OH 43210</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="AF0013"><institution>Department of Health Sciences Research, Mayo Clinic</institution>,<addr-line>Rochester, MN 55905</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation><nlm:aff id="AF0056"><institution>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Aghia Paraskevi Attikis, 153 10 Athens</addr-line>,<country>Greece</country>,</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff wicri:cut=" and" id="AF0053"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</institution></nlm:aff></affiliation><affiliation><nlm:aff id="AF0057"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>,<addr-line>Melbourne, Victoria 3053</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff wicri:cut=" and" id="AF0053"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</institution></nlm:aff></affiliation><affiliation><nlm:aff id="AF0057"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>,<addr-line>Melbourne, Victoria 3053</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="AF0058"><institution>Anatomical Pathology, The Alfred Hospital</institution>,<addr-line>Melbourne, Victoria 3004</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name></author><author><name sortKey="Ruebner, Matthias" sort="Ruebner, Matthias" uniqKey="Ruebner M" first="Matthias" last="Ruebner">Matthias Ruebner</name><affiliation><nlm:aff id="AF0059"><institution>Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg</institution>,<addr-line>91054 Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0060"><institution>Comprehensive Cancer Center Erlangen-EMN</institution>,<addr-line>91054 Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="AF0060"><institution>Comprehensive Cancer Center Erlangen-EMN</institution>,<addr-line>91054 Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0062"><institution>Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg</institution>,<addr-line>91054 Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="AF0059"><institution>Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg</institution>,<addr-line>91054 Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0060"><institution>Comprehensive Cancer Center Erlangen-EMN</institution>,<addr-line>91054 Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="AF0063"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0064"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Dieffenbach, Aida K" sort="Dieffenbach, Aida K" uniqKey="Dieffenbach A" first="Aida K." last="Dieffenbach">Aida K. Dieffenbach</name><affiliation><nlm:aff id="AF0063"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0064"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="AF0063"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="AF0065"><institution>Saarland Cancer Registry</institution>,<addr-line>66119 Saarbrücken</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="AF0018"><institution>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research</institution>,<addr-line>London, SW3 6JB</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Orr, Nicholas" sort="Orr, Nicholas" uniqKey="Orr N" first="Nicholas" last="Orr">Nicholas Orr</name><affiliation><nlm:aff id="AF0018"><institution>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research</institution>,<addr-line>London, SW3 6JB</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J." last="Schoemaker">Minouk J. Schoemaker</name><affiliation><nlm:aff wicri:cut=" and" id="AF0066"><institution>Division of Genetics and Epidemiology</institution></nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff wicri:cut=" and" id="AF0066"><institution>Division of Genetics and Epidemiology</institution></nlm:aff></affiliation><affiliation><nlm:aff id="AF0067"><institution>Division of Breast Cancer Research, Institute of Cancer Research</institution>,<addr-line>London, SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="AF0018"><institution>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research</institution>,<addr-line>London, SW3 6JB</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="AF0066"><institution>Division of Genetics and Epidemiology</institution></nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="AF0068"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>,<addr-line>Rockville, MD 20850</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="AF0068"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>,<addr-line>Rockville, MD 20850</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="AF0069"><institution>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology</institution>,<addr-line>02-781 Warsaw</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name><affiliation><nlm:aff id="AF0070"><institution>Department of Medicine, McGill University</institution>,<addr-line>Montreal, QC, H3G 2M1</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0071"><institution>Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital</institution>,<addr-line>Montreal, QC H3G 2M1</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Labreche, France" sort="Labreche, France" uniqKey="Labreche F" first="France" last="Labrèche">France Labrèche</name><affiliation><nlm:aff id="AF0072"><institution>Département de santé environnementale et santé au travail, Département de médecine sociale et preventive, École de santé publique, Université de Montréal</institution>,<addr-line>Montreal, QC, H3T 1A8</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="AF0073"><institution>Centre Hospitalier Universitaire de Québec Research Center and Laval University</institution>,<addr-line>QC, G1V 4G2</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="AF0074"><institution>Department of Clinical Chemistry and Biocenter Oulu, Laboratory of Cancer Genetics and Tumor Biology, University of Oulu, NordLab Oulu/Oulu University Hospital</institution>,<addr-line>FI-90220 Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="AF0074"><institution>Department of Clinical Chemistry and Biocenter Oulu, Laboratory of Cancer Genetics and Tumor Biology, University of Oulu, NordLab Oulu/Oulu University Hospital</institution>,<addr-line>FI-90220 Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff wicri:cut=" and" id="AF0075"><institution>Department of Oncology</institution></nlm:aff></affiliation></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name><affiliation><nlm:aff id="AF0076"><institution>Department of Surgery, Oulu University Hospital, University of Oulu</institution>,<addr-line>FI-90220 Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="AF0080"><institution>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA)</institution>,<addr-line>44789 Bochum</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation><nlm:aff id="AF0081"><institution>Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus</institution>,<addr-line>53113 Bonn</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="AF0084"><institution>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>20133 Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="AF0085"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>20139 Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Scuvera, Giulietta" sort="Scuvera, Giulietta" uniqKey="Scuvera G" first="Giulietta" last="Scuvera">Giulietta Scuvera</name><affiliation><nlm:aff id="AF0086"><institution>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>20133 Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Fortuzzi, Stefano" sort="Fortuzzi, Stefano" uniqKey="Fortuzzi S" first="Stefano" last="Fortuzzi">Stefano Fortuzzi</name><affiliation><nlm:aff id="AF0085"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>20139 Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0087"><institution>Cogentech Cancer Genetic Test Laboratory</institution>,<addr-line>20139 Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia" sort="Bogdanova, Natalia" uniqKey="Bogdanova N" first="Natalia" last="Bogdanova">Natalia Bogdanova</name><affiliation><nlm:aff wicri:cut=" and" id="AF0088"><institution>Department of Radiation Oncology</institution></nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="AF0089"><institution>Department of Obstetrics and Gynaecology, Hannover Medical School</institution>,<addr-line>30625 Hannover</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="AF0096"><institution>Department of Human Genetics and Department of Pathology</institution>,</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff wicri:cut=" and" id="AF0097"><institution>Department of Surgical Oncology</institution></nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff wicri:cut=" and" id="AF0051"><institution>Department of Medical Oncology</institution></nlm:aff></affiliation></author><author><name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J." last="Van Asperen">Christi J. Van Asperen</name><affiliation><nlm:aff id="AF0098"><institution>Department of Clinical Genetics, Leiden University Medical Center</institution>,<addr-line>2333 ZC Leiden</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="AF0099"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>,<addr-line>70–115 Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="AF0099"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>,<addr-line>70–115 Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name><affiliation><nlm:aff id="AF0099"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>,<addr-line>70–115 Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="AF0099"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>,<addr-line>70–115 Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="AF0100"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37203</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Martha J" sort="Shrubsole, Martha J" uniqKey="Shrubsole M" first="Martha J." last="Shrubsole">Martha J. Shrubsole</name><affiliation><nlm:aff id="AF0100"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37203</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="AF0100"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37203</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation><nlm:aff id="AF0001"><institution>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0101"><institution>Institute of Human Genetics, Pontificia Universidad Javeriana</institution>,<addr-line>11001000 Bogotá</addr-line>,<country>Colombia</country>,</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="AF0102"><institution>Department of Epidemiology, University of California Irvine</institution>,<addr-line>Irvine, CA 92697</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name></author><author><name sortKey="Bacot, Francois" sort="Bacot, Francois" uniqKey="Bacot F" first="François" last="Bacot">François Bacot</name><affiliation><nlm:aff wicri:cut=" and" id="AF0106"><institution>McGill University and Génome Québec Innovation Centre</institution>,<addr-line>Montréal, QC H3A 0G1</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Tessier, Daniel C" sort="Tessier, Daniel C" uniqKey="Tessier D" first="Daniel C." last="Tessier">Daniel C. Tessier</name><affiliation><nlm:aff wicri:cut=" and" id="AF0106"><institution>McGill University and Génome Québec Innovation Centre</institution>,<addr-line>Montréal, QC H3A 0G1</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name><affiliation><nlm:aff wicri:cut=" and" id="AF0106"><institution>McGill University and Génome Québec Innovation Centre</institution>,<addr-line>Montréal, QC H3A 0G1</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name><affiliation><nlm:aff id="AF0004"><institution>Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>,<addr-line>Cambridge, CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name><affiliation><nlm:aff id="AF0004"><institution>Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>,<addr-line>Cambridge, CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name><affiliation><nlm:aff id="AF0004"><institution>Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>,<addr-line>Cambridge, CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Maranian, Mel" sort="Maranian, Mel" uniqKey="Maranian M" first="Mel" last="Maranian">Mel Maranian</name><affiliation><nlm:aff id="AF0004"><institution>Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>,<addr-line>Cambridge, CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="AF0073"><institution>Centre Hospitalier Universitaire de Québec Research Center and Laval University</institution>,<addr-line>QC, G1V 4G2</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="AF0107"><institution>Department of Genetics, QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane, QLD 4006</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="AF0005"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm, SE-17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="AF0034"><institution>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco</institution>,<addr-line>33012 Oviedo</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="AF0004"><institution>Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>,<addr-line>Cambridge, CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="AF0034"><institution>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco</institution>,<addr-line>33012 Oviedo</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="AF0001"><institution>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25586992</idno><idno type="pmc">4335262</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335262</idno><idno type="RBID">PMC:4335262</idno><idno type="doi">10.1093/carcin/bgu326</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001822</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001822</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer</title><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation><nlm:aff id="AF0001"><institution>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Lorenzo Bermejo, Justo" sort="Lorenzo Bermejo, Justo" uniqKey="Lorenzo Bermejo J" first="Justo" last="Lorenzo Bermejo">Justo Lorenzo Bermejo</name><affiliation><nlm:aff id="AF0002"><institution>Institute of Medical Biometry and Informatics, University Hospital Heidelberg</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Dunnebier, Thomas" sort="Dunnebier, Thomas" uniqKey="Dunnebier T" first="Thomas" last="Dünnebier">Thomas Dünnebier</name><affiliation><nlm:aff id="AF0001"><institution>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Ying, Shibo" sort="Ying, Shibo" uniqKey="Ying S" first="Shibo" last="Ying">Shibo Ying</name><affiliation><nlm:aff id="AF0001"><institution>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff wicri:cut=" and" id="AF0003"><institution>Department of Public Health and Primary Care</institution></nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff wicri:cut=" and" id="AF0003"><institution>Department of Public Health and Primary Care</institution></nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff wicri:cut=" and" id="AF0003"><institution>Department of Public Health and Primary Care</institution></nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff wicri:cut=" and" id="AF0003"><institution>Department of Public Health and Primary Care</institution></nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="AF0004"><institution>Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>,<addr-line>Cambridge, CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Perkins, Barbara J" sort="Perkins, Barbara J" uniqKey="Perkins B" first="Barbara J." last="Perkins">Barbara J. Perkins</name><affiliation><nlm:aff id="AF0004"><institution>Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>,<addr-line>Cambridge, CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="AF0005"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm, SE-17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="AF0005"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm, SE-17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name><affiliation><nlm:aff id="AF0005"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm, SE-17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="AF0006"><institution>Copenhagen General Population Study</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="AF0007"><institution>Department of Clinical Biochemistry</institution></nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="AF0006"><institution>Copenhagen General Population Study</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="AF0007"><institution>Department of Clinical Biochemistry</institution></nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="AF0006"><institution>Copenhagen General Population Study</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="AF0007"><institution>Department of Clinical Biochemistry</institution></nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="AF0008"><institution>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital</institution>,<addr-line>2730 Herlev</addr-line>,<country>Denmark</country>,</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="AF0009"><institution>Vesalius Research Center, VIB</institution>,<addr-line>3000 Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0010"><institution>Department of Oncology, Laboratory for Translational Genetics, University of Leuven</institution>,<addr-line>3000 Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation></author><author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name><affiliation><nlm:aff id="AF0011"><institution>Department of Oncology, KU Leuven (University of Leuven), Multidisciplinary Breast Center, University Hospitals Leuven</institution>,<addr-line>3000 Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation></author><author><name sortKey="Peeters, Stephanie" sort="Peeters, Stephanie" uniqKey="Peeters S" first="Stephanie" last="Peeters">Stephanie Peeters</name><affiliation><nlm:aff id="AF0011"><institution>Department of Oncology, KU Leuven (University of Leuven), Multidisciplinary Breast Center, University Hospitals Leuven</institution>,<addr-line>3000 Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation></author><author><name sortKey="Weltens, Caroline" sort="Weltens, Caroline" uniqKey="Weltens C" first="Caroline" last="Weltens">Caroline Weltens</name><affiliation><nlm:aff id="AF0011"><institution>Department of Oncology, KU Leuven (University of Leuven), Multidisciplinary Breast Center, University Hospitals Leuven</institution>,<addr-line>3000 Leuven</addr-line>,<country>Belgium</country>,</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff wicri:cut=" and" id="AF0012"><institution>Department of Laboratory Medicine and Pathology</institution></nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="AF0013"><institution>Department of Health Sciences Research, Mayo Clinic</institution>,<addr-line>Rochester, MN 55905</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff wicri:cut=" and" id="AF0012"><institution>Department of Laboratory Medicine and Pathology</institution></nlm:aff></affiliation></author><author><name sortKey="Purrington, Kristen" sort="Purrington, Kristen" uniqKey="Purrington K" first="Kristen" last="Purrington">Kristen Purrington</name><affiliation><nlm:aff id="AF0014"><institution>Karmanos Cancer Institute</institution>,<addr-line>Detroit, MI 48201</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="AF0015"><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="AF0015"><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Seibold, Petra" sort="Seibold, Petra" uniqKey="Seibold P" first="Petra" last="Seibold">Petra Seibold</name><affiliation><nlm:aff id="AF0015"><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="AF0016"><institution>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf</institution>,<addr-line>20246 Hamburg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="AF0017"><institution>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine</institution>,<country>London</country>,<addr-line>WC1E 7HT</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:aff id="AF0017"><institution>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine</institution>,<country>London</country>,<addr-line>WC1E 7HT</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="AF0018"><institution>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research</institution>,<addr-line>London, SW3 6JB</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="AF0018"><institution>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research</institution>,<addr-line>London, SW3 6JB</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="AF0019"><institution>Department of Obstetrics and Gynecology</institution>,</nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="AF0019"><institution>Department of Obstetrics and Gynecology</institution>,</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff wicri:cut=" and" id="AF0020"><institution>Department of Clinical Genetics</institution></nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="AF0021"><institution>Department of Oncology, University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>FI-00029 Helsinki</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="AF0022"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>1066 CX Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="AF0022"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>1066 CX Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Cornelissen, Sten" sort="Cornelissen, Sten" uniqKey="Cornelissen S" first="Sten" last="Cornelissen">Sten Cornelissen</name><affiliation><nlm:aff id="AF0022"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>1066 CX Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name><affiliation><nlm:aff id="AF0022"><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>1066 CX Amsterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="AF0023"><institution>Human Genetics Division, Genome Institute of Singapore</institution>,<addr-line>Singapore 138672</addr-line>,<country>Singapore</country>,</nlm:aff></affiliation></author><author><name sortKey="Brand, Judith S" sort="Brand, Judith S" uniqKey="Brand J" first="Judith S." last="Brand">Judith S. Brand</name><affiliation><nlm:aff id="AF0005"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm, SE-17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="AF0005"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm, SE-17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="AF0024"><institution>National Institute of Health and Medical Research, Center for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0025"><institution>University Paris-Sud</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="AF0024"><institution>National Institute of Health and Medical Research, Center for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0025"><institution>University Paris-Sud</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation><nlm:aff id="AF0024"><institution>National Institute of Health and Medical Research, Center for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0025"><institution>University Paris-Sud</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Sanchez, Marie" sort="Sanchez, Marie" uniqKey="Sanchez M" first="Marie" last="Sanchez">Marie Sanchez</name><affiliation><nlm:aff id="AF0024"><institution>National Institute of Health and Medical Research, Center for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0025"><institution>University Paris-Sud</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="AF0026"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0027"><institution>Molecular Epidemiology Group, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marmé">Frederik Marmé</name><affiliation><nlm:aff id="AF0026"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0028"><institution>National Center for Tumor Diseases, University of Heidelberg</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Yang, Rongxi" sort="Yang, Rongxi" uniqKey="Yang R" first="Rongxi" last="Yang">Rongxi Yang</name><affiliation><nlm:aff id="AF0026"><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0027"><institution>Molecular Epidemiology Group, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Bugert, Peter" sort="Bugert, Peter" uniqKey="Bugert P" first="Peter" last="Bugert">Peter Bugert</name><affiliation><nlm:aff id="AF0029"><institution>Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University</institution>,<addr-line>68167 Mannheim</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation><nlm:aff id="AF0030"><institution>Human Genotyping-CEGEN Unit</institution>and</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name></author><author><name sortKey="Pilar Zamora, M" sort="Pilar Zamora, M" uniqKey="Pilar Zamora M" first="M." last="Pilar Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="AF0033"><institution>Servicio de Oncología Médica, Hospital Universitario La Paz</institution>,<addr-line>28046 Madrid</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Arias Perez, Jose I" sort="Arias Perez, Jose I" uniqKey="Arias Perez J" first="Jose I." last="Arias Perez">Jose I. Arias Perez</name><affiliation><nlm:aff id="AF0034"><institution>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco</institution>,<addr-line>33012 Oviedo</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="AF0035"><institution>Department of Oncology, University of Sheffield</institution>,<addr-line>Sheffield, S10 2RX</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="AF0036"><institution>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield</institution>,<addr-line>Sheffield S10 2HQ</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="AF0035"><institution>Department of Oncology, University of Sheffield</institution>,<addr-line>Sheffield, S10 2RX</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="AF0037"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto, ON M5G 1X5</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0038"><institution>Department of Molecular Genetics, University of Toronto</institution>,<addr-line>Toronto, ON M5S 1A8</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="AF0039"><institution>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto, ON M5G 1X5</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0040"><institution>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto</institution>,<addr-line>Toronto, ON M5T 3M7</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="AF0041"><institution>ON Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto, ON, M5G 1X5</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name><affiliation><nlm:aff id="AF0037"><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto, ON M5G 1X5</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="AF0042"><institution>Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital</institution>,<addr-line>London SE1 9RT</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="AF0043"><institution>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford</institution>,<addr-line>Oxford OX3 7BN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name><affiliation><nlm:aff id="AF0044"><institution>Clinical Science Institute, University Hospital Galway</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country>,</nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="AF0044"><institution>Clinical Science Institute, University Hospital Galway</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country>,</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="AF0047"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation><nlm:aff id="AF0047"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="AF0047"><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="AF0048"><institution>Epidemiology Program, University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI 96813</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff wicri:cut=" and" id="AF0049"><institution>Department of Molecular Medicine and Surgery</institution></nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="AF0050"><institution>Department of Oncology - Pathology, Karolinska Institutet</institution>,<addr-line>Stockholm SE-17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff wicri:cut=" and" id="AF0051"><institution>Department of Medical Oncology</institution></nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff wicri:cut=" and" id="AF0051"><institution>Department of Medical Oncology</institution></nlm:aff></affiliation></author><author><name sortKey="Kriege, Mieke" sort="Kriege, Mieke" uniqKey="Kriege M" first="Mieke" last="Kriege">Mieke Kriege</name><affiliation><nlm:aff wicri:cut=" and" id="AF0051"><institution>Department of Medical Oncology</institution></nlm:aff></affiliation></author><author><name sortKey="Koppert, Linetta B" sort="Koppert, Linetta B" uniqKey="Koppert L" first="Linetta B." last="Koppert">Linetta B. Koppert</name><affiliation><nlm:aff id="AF0052"><institution>Department of Surgical Oncology, Erasmus MC Cancer Institute</institution>,<addr-line>3008 AE Rotterdam</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff wicri:cut=" and" id="AF0053"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</institution></nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="AF0054"><institution>Department of Pathology, The University of Melbourne</institution>,<addr-line>Melbourne, Victoria 3010</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation><nlm:aff id="AF0054"><institution>Department of Pathology, The University of Melbourne</institution>,<addr-line>Melbourne, Victoria 3010</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff wicri:cut=" and" id="AF0053"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</institution></nlm:aff></affiliation></author><author><name sortKey="Slettedahl, Seth" sort="Slettedahl, Seth" uniqKey="Slettedahl S" first="Seth" last="Slettedahl">Seth Slettedahl</name><affiliation><nlm:aff id="AF0013"><institution>Department of Health Sciences Research, Mayo Clinic</institution>,<addr-line>Rochester, MN 55905</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="AF0055"><institution>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University</institution>,<addr-line>Columbus, OH 43210</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="AF0013"><institution>Department of Health Sciences Research, Mayo Clinic</institution>,<addr-line>Rochester, MN 55905</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation><nlm:aff id="AF0056"><institution>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Aghia Paraskevi Attikis, 153 10 Athens</addr-line>,<country>Greece</country>,</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff wicri:cut=" and" id="AF0053"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</institution></nlm:aff></affiliation><affiliation><nlm:aff id="AF0057"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>,<addr-line>Melbourne, Victoria 3053</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff wicri:cut=" and" id="AF0053"><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</institution></nlm:aff></affiliation><affiliation><nlm:aff id="AF0057"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>,<addr-line>Melbourne, Victoria 3053</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="AF0058"><institution>Anatomical Pathology, The Alfred Hospital</institution>,<addr-line>Melbourne, Victoria 3004</addr-line>,<country>Australia</country>,</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name></author><author><name sortKey="Ruebner, Matthias" sort="Ruebner, Matthias" uniqKey="Ruebner M" first="Matthias" last="Ruebner">Matthias Ruebner</name><affiliation><nlm:aff id="AF0059"><institution>Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg</institution>,<addr-line>91054 Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0060"><institution>Comprehensive Cancer Center Erlangen-EMN</institution>,<addr-line>91054 Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="AF0060"><institution>Comprehensive Cancer Center Erlangen-EMN</institution>,<addr-line>91054 Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0062"><institution>Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg</institution>,<addr-line>91054 Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="AF0059"><institution>Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg</institution>,<addr-line>91054 Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0060"><institution>Comprehensive Cancer Center Erlangen-EMN</institution>,<addr-line>91054 Erlangen</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="AF0063"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0064"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Dieffenbach, Aida K" sort="Dieffenbach, Aida K" uniqKey="Dieffenbach A" first="Aida K." last="Dieffenbach">Aida K. Dieffenbach</name><affiliation><nlm:aff id="AF0063"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0064"><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="AF0063"><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="AF0065"><institution>Saarland Cancer Registry</institution>,<addr-line>66119 Saarbrücken</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="AF0018"><institution>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research</institution>,<addr-line>London, SW3 6JB</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Orr, Nicholas" sort="Orr, Nicholas" uniqKey="Orr N" first="Nicholas" last="Orr">Nicholas Orr</name><affiliation><nlm:aff id="AF0018"><institution>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research</institution>,<addr-line>London, SW3 6JB</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J." last="Schoemaker">Minouk J. Schoemaker</name><affiliation><nlm:aff wicri:cut=" and" id="AF0066"><institution>Division of Genetics and Epidemiology</institution></nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff wicri:cut=" and" id="AF0066"><institution>Division of Genetics and Epidemiology</institution></nlm:aff></affiliation><affiliation><nlm:aff id="AF0067"><institution>Division of Breast Cancer Research, Institute of Cancer Research</institution>,<addr-line>London, SM2 5NG</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="AF0018"><institution>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research</institution>,<addr-line>London, SW3 6JB</addr-line>,<country>UK</country>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="AF0066"><institution>Division of Genetics and Epidemiology</institution></nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="AF0068"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>,<addr-line>Rockville, MD 20850</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="AF0068"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>,<addr-line>Rockville, MD 20850</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="AF0069"><institution>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology</institution>,<addr-line>02-781 Warsaw</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name><affiliation><nlm:aff id="AF0070"><institution>Department of Medicine, McGill University</institution>,<addr-line>Montreal, QC, H3G 2M1</addr-line>,<country>Canada</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0071"><institution>Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital</institution>,<addr-line>Montreal, QC H3G 2M1</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Labreche, France" sort="Labreche, France" uniqKey="Labreche F" first="France" last="Labrèche">France Labrèche</name><affiliation><nlm:aff id="AF0072"><institution>Département de santé environnementale et santé au travail, Département de médecine sociale et preventive, École de santé publique, Université de Montréal</institution>,<addr-line>Montreal, QC, H3T 1A8</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="AF0073"><institution>Centre Hospitalier Universitaire de Québec Research Center and Laval University</institution>,<addr-line>QC, G1V 4G2</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="AF0074"><institution>Department of Clinical Chemistry and Biocenter Oulu, Laboratory of Cancer Genetics and Tumor Biology, University of Oulu, NordLab Oulu/Oulu University Hospital</institution>,<addr-line>FI-90220 Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="AF0074"><institution>Department of Clinical Chemistry and Biocenter Oulu, Laboratory of Cancer Genetics and Tumor Biology, University of Oulu, NordLab Oulu/Oulu University Hospital</institution>,<addr-line>FI-90220 Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff wicri:cut=" and" id="AF0075"><institution>Department of Oncology</institution></nlm:aff></affiliation></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name><affiliation><nlm:aff id="AF0076"><institution>Department of Surgery, Oulu University Hospital, University of Oulu</institution>,<addr-line>FI-90220 Oulu</addr-line>,<country>Finland</country>,</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="AF0080"><institution>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA)</institution>,<addr-line>44789 Bochum</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation><nlm:aff id="AF0081"><institution>Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus</institution>,<addr-line>53113 Bonn</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="AF0084"><institution>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>20133 Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="AF0085"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>20139 Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Scuvera, Giulietta" sort="Scuvera, Giulietta" uniqKey="Scuvera G" first="Giulietta" last="Scuvera">Giulietta Scuvera</name><affiliation><nlm:aff id="AF0086"><institution>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>20133 Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Fortuzzi, Stefano" sort="Fortuzzi, Stefano" uniqKey="Fortuzzi S" first="Stefano" last="Fortuzzi">Stefano Fortuzzi</name><affiliation><nlm:aff id="AF0085"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>20139 Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0087"><institution>Cogentech Cancer Genetic Test Laboratory</institution>,<addr-line>20139 Milan</addr-line>,<country>Italy</country>,</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia" sort="Bogdanova, Natalia" uniqKey="Bogdanova N" first="Natalia" last="Bogdanova">Natalia Bogdanova</name><affiliation><nlm:aff wicri:cut=" and" id="AF0088"><institution>Department of Radiation Oncology</institution></nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="AF0089"><institution>Department of Obstetrics and Gynaecology, Hannover Medical School</institution>,<addr-line>30625 Hannover</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="AF0096"><institution>Department of Human Genetics and Department of Pathology</institution>,</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff wicri:cut=" and" id="AF0097"><institution>Department of Surgical Oncology</institution></nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff wicri:cut=" and" id="AF0051"><institution>Department of Medical Oncology</institution></nlm:aff></affiliation></author><author><name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J." last="Van Asperen">Christi J. Van Asperen</name><affiliation><nlm:aff id="AF0098"><institution>Department of Clinical Genetics, Leiden University Medical Center</institution>,<addr-line>2333 ZC Leiden</addr-line>,<country>The Netherlands</country>,</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="AF0099"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>,<addr-line>70–115 Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="AF0099"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>,<addr-line>70–115 Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name><affiliation><nlm:aff id="AF0099"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>,<addr-line>70–115 Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="AF0099"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>,<addr-line>70–115 Szczecin</addr-line>,<country>Poland</country>,</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="AF0100"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37203</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Martha J" sort="Shrubsole, Martha J" uniqKey="Shrubsole M" first="Martha J." last="Shrubsole">Martha J. Shrubsole</name><affiliation><nlm:aff id="AF0100"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37203</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="AF0100"><institution>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37203</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation><nlm:aff id="AF0001"><institution>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation><affiliation><nlm:aff id="AF0101"><institution>Institute of Human Genetics, Pontificia Universidad Javeriana</institution>,<addr-line>11001000 Bogotá</addr-line>,<country>Colombia</country>,</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="AF0102"><institution>Department of Epidemiology, University of California Irvine</institution>,<addr-line>Irvine, CA 92697</addr-line>,<country>USA</country>,</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name></author><author><name sortKey="Bacot, Francois" sort="Bacot, Francois" uniqKey="Bacot F" first="François" last="Bacot">François Bacot</name><affiliation><nlm:aff wicri:cut=" and" id="AF0106"><institution>McGill University and Génome Québec Innovation Centre</institution>,<addr-line>Montréal, QC H3A 0G1</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Tessier, Daniel C" sort="Tessier, Daniel C" uniqKey="Tessier D" first="Daniel C." last="Tessier">Daniel C. Tessier</name><affiliation><nlm:aff wicri:cut=" and" id="AF0106"><institution>McGill University and Génome Québec Innovation Centre</institution>,<addr-line>Montréal, QC H3A 0G1</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name><affiliation><nlm:aff wicri:cut=" and" id="AF0106"><institution>McGill University and Génome Québec Innovation Centre</institution>,<addr-line>Montréal, QC H3A 0G1</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name><affiliation><nlm:aff id="AF0004"><institution>Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>,<addr-line>Cambridge, CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name><affiliation><nlm:aff id="AF0004"><institution>Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>,<addr-line>Cambridge, CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name><affiliation><nlm:aff id="AF0004"><institution>Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>,<addr-line>Cambridge, CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Maranian, Mel" sort="Maranian, Mel" uniqKey="Maranian M" first="Mel" last="Maranian">Mel Maranian</name><affiliation><nlm:aff id="AF0004"><institution>Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>,<addr-line>Cambridge, CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="AF0073"><institution>Centre Hospitalier Universitaire de Québec Research Center and Laval University</institution>,<addr-line>QC, G1V 4G2</addr-line>,<country>Canada</country>,</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="AF0107"><institution>Department of Genetics, QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane, QLD 4006</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="AF0005"><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm, SE-17177</addr-line>,<country>Sweden</country>,</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="AF0034"><institution>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco</institution>,<addr-line>33012 Oviedo</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="AF0004"><institution>Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>,<addr-line>Cambridge, CB1 8RN</addr-line>,<country>UK</country>,</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="AF0034"><institution>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco</institution>,<addr-line>33012 Oviedo</addr-line>,<country>Spain</country>,</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="AF0001"><institution>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff></affiliation></author></analytic><series><title level="j">Carcinogenesis</title><idno type="ISSN">0143-3334</idno><idno type="eISSN">1460-2180</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>This is the first study investigating the contribution of inherited variants in core genes of the chromosomal passenger complex to breast cancer susceptibility. It was found that several <italic>INCENP</italic> variants are associated with the risk of ER-negative breast cancer in the European population.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Carcinogenesis</journal-id><journal-id journal-id-type="iso-abbrev">Carcinogenesis</journal-id><journal-id journal-id-type="hwp">carcin</journal-id><journal-id journal-id-type="publisher-id">carcin</journal-id><journal-title-group><journal-title>Carcinogenesis</journal-title></journal-title-group><issn pub-type="ppub">0143-3334</issn><issn pub-type="epub">1460-2180</issn><publisher><publisher-name>Oxford University Press</publisher-name><publisher-loc>UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25586992</article-id><article-id pub-id-type="pmc">4335262</article-id><article-id pub-id-type="doi">10.1093/carcin/bgu326</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Manuscript</subject></subj-group></article-categories><title-group><article-title>Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kabisch</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref><xref ref-type="corresp" rid="c2"><sup>†</sup></xref><xref ref-type="corresp" rid="c3"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lorenzo Bermejo</surname><given-names>Justo</given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref><xref ref-type="corresp" rid="c2"><sup>†</sup></xref><xref ref-type="corresp" rid="c3"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dünnebier</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref><xref ref-type="corresp" rid="c3"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ying</surname><given-names>Shibo</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Michailidou</surname><given-names>Kyriaki</given-names></name><xref ref-type="aff" rid="AF0003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bolla</surname><given-names>Manjeet K.</given-names></name><xref ref-type="aff" rid="AF0003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Qin</given-names></name><xref ref-type="aff" rid="AF0003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dennis</surname><given-names>Joe</given-names></name><xref ref-type="aff" rid="AF0003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shah</surname><given-names>Mitul</given-names></name><xref ref-type="aff" rid="AF0004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Perkins</surname><given-names>Barbara J.</given-names></name><xref ref-type="aff" 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contrib-type="author"><name><surname>Weltens</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="AF0011"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus J.</given-names></name><xref ref-type="aff" rid="AF0012"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Olson</surname><given-names>Janet E.</given-names></name><xref ref-type="aff" rid="AF0013"><sup>13</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Xianshu</given-names></name><xref ref-type="aff" rid="AF0012"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Purrington</surname><given-names>Kristen</given-names></name><xref ref-type="aff" rid="AF0014"><sup>14</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><xref ref-type="aff" rid="AF0015"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rudolph</surname><given-names>Anja</given-names></name><xref ref-type="aff" rid="AF0015"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Seibold</surname><given-names>Petra</given-names></name><xref ref-type="aff" rid="AF0015"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Flesch-Janys</surname><given-names>Dieter</given-names></name><xref ref-type="aff" rid="AF0016"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>Peto</surname><given-names>Julian</given-names></name><xref ref-type="aff" rid="AF0017"><sup>17</sup></xref></contrib><contrib contrib-type="author"><name><surname>dos-Santos-Silva</surname><given-names>Isabel</given-names></name><xref ref-type="aff" rid="AF0017"><sup>17</sup></xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Nichola</given-names></name><xref 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rid="AF0030"><sup>30</sup></xref></contrib><contrib contrib-type="author"><name><surname>Benitez</surname><given-names>Javier</given-names></name><xref ref-type="aff" rid="AF0030 AF0031 AF0032"><sup>30–32</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pilar Zamora</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="AF0033"><sup>33</sup></xref></contrib><contrib contrib-type="author"><name><surname>Arias Perez</surname><given-names>Jose I.</given-names></name><xref ref-type="aff" rid="AF0034"><sup>34</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cox</surname><given-names>Angela</given-names></name><xref ref-type="aff" rid="AF0035"><sup>35</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cross</surname><given-names>Simon S.</given-names></name><xref ref-type="aff" rid="AF0036"><sup>36</sup></xref></contrib><contrib contrib-type="author"><name><surname>Reed</surname><given-names>Malcolm 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rid="AF0071"><sup>71</sup></xref></contrib><contrib contrib-type="author"><name><surname>Labrèche</surname><given-names>France</given-names></name><xref ref-type="aff" rid="AF0072"><sup>72</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dumont</surname><given-names>Martine</given-names></name><xref ref-type="aff" rid="AF0073"><sup>73</sup></xref></contrib><contrib contrib-type="author"><name><surname>Winqvist</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="AF0074"><sup>74</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pylkäs</surname><given-names>Katri</given-names></name><xref ref-type="aff" rid="AF0074"><sup>74</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jukkola-Vuorinen</surname><given-names>Arja</given-names></name><xref ref-type="aff" rid="AF0075"><sup>75</sup></xref></contrib><contrib contrib-type="author"><name><surname>Grip</surname><given-names>Mervi</given-names></name><xref ref-type="aff" rid="AF0076"><sup>76</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brauch</surname><given-names>Hiltrud</given-names></name><xref ref-type="aff" rid="AF0077 AF0078 AF0079"><sup>77–79</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brüning</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="AF0080"><sup>80</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ko</surname><given-names>Yon-Dschun</given-names></name><xref ref-type="aff" rid="AF0081"><sup>81</sup></xref></contrib><contrib contrib-type="author"><collab>The GENICA Network</collab><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref><xref ref-type="aff" rid="AF0077 AF0078 AF0079 AF0080 AF0081 AF0082 AF0083"><sup>77–83</sup></xref></contrib><contrib contrib-type="author"><name><surname>Radice</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="AF0084"><sup>84</sup></xref></contrib><contrib contrib-type="author"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="AF0085"><sup>85</sup></xref></contrib><contrib contrib-type="author"><name><surname>Scuvera</surname><given-names>Giulietta</given-names></name><xref ref-type="aff" rid="AF0086"><sup>86</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fortuzzi</surname><given-names>Stefano</given-names></name><xref ref-type="aff" rid="AF0085"><sup>85</sup></xref><xref ref-type="aff" rid="AF0087"><sup>87</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bogdanova</surname><given-names>Natalia</given-names></name><xref ref-type="aff" rid="AF0088"><sup>88</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dörk</surname><given-names>Thilo</given-names></name><xref ref-type="aff" rid="AF0089"><sup>89</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mannermaa</surname><given-names>Arto</given-names></name><xref ref-type="aff" rid="AF0090 AF0091 AF0092"><sup>90–92</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kataja</surname><given-names>Vesa</given-names></name><xref ref-type="aff" rid="AF0093 AF0094 AF0095"><sup>93–95</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kosma</surname><given-names>Veli-Matti</given-names></name><xref ref-type="aff" rid="AF0090 AF0091 AF0092"><sup>90–92</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hartikainen</surname><given-names>Jaana M.</given-names></name><xref ref-type="aff" rid="AF0090 AF0091 AF0092"><sup>90–92</sup></xref></contrib><contrib contrib-type="author"><name><surname>Devilee</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="AF0096"><sup>96</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tollenaar</surname><given-names>Robert A.E.M.</given-names></name><xref ref-type="aff" rid="AF0097"><sup>97</sup></xref></contrib><contrib contrib-type="author"><name><surname>Seynaeve</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="AF0051"><sup>51</sup></xref></contrib><contrib contrib-type="author"><name><surname>Van Asperen</surname><given-names>Christi J.</given-names></name><xref ref-type="aff" rid="AF0098"><sup>98</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jakubowska</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="AF0099"><sup>99</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lubinski</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="AF0099"><sup>99</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jaworska-Bieniek</surname><given-names>Katarzyna</given-names></name><xref ref-type="aff" rid="AF0099"><sup>99</sup></xref></contrib><contrib contrib-type="author"><name><surname>Durda</surname><given-names>Katarzyna</given-names></name><xref ref-type="aff" rid="AF0099"><sup>99</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Wei</given-names></name><xref ref-type="aff" rid="AF0100"><sup>100</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shrubsole</surname><given-names>Martha J.</given-names></name><xref ref-type="aff" rid="AF0100"><sup>100</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cai</surname><given-names>Qiuyin</given-names></name><xref ref-type="aff" rid="AF0100"><sup>100</sup></xref></contrib><contrib contrib-type="author"><name><surname>Torres</surname><given-names>Diana</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref><xref ref-type="aff" rid="AF0101"><sup>101</sup></xref></contrib><contrib contrib-type="author"><name><surname>Anton-Culver</surname><given-names>Hoda</given-names></name><xref ref-type="aff" rid="AF0102"><sup>102</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kristensen</surname><given-names>Vessela</given-names></name><xref ref-type="aff" rid="AF0103 AF0104 AF0105"><sup>103–105</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bacot</surname><given-names>François</given-names></name><xref ref-type="aff" rid="AF0106"><sup>106</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tessier</surname><given-names>Daniel C.</given-names></name><xref ref-type="aff" rid="AF0106"><sup>106</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vincent</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="AF0106"><sup>106</sup></xref></contrib><contrib contrib-type="author"><name><surname>Luccarini</surname><given-names>Craig</given-names></name><xref ref-type="aff" rid="AF0004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Baynes</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="AF0004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ahmed</surname><given-names>Shahana</given-names></name><xref ref-type="aff" rid="AF0004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Maranian</surname><given-names>Mel</given-names></name><xref ref-type="aff" rid="AF0004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Simard</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="AF0073"><sup>73</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="AF0107"><sup>107</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><xref ref-type="aff" rid="AF0005"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul D.P.</given-names></name><xref ref-type="aff" rid="AF0034"><sup>34</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M.</given-names></name><xref ref-type="aff" rid="AF0004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="AF0034"><sup>34</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref><xref ref-type="corresp" rid="c1">*</xref><xref ref-type="corresp" rid="c3"><sup>‡</sup></xref></contrib><aff id="AF0001"><sup>1</sup><institution>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="AF0002"><sup>2</sup><institution>Institute of Medical Biometry and Informatics, University Hospital Heidelberg</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="AF0003"><sup>3</sup><institution>Department of Public Health and Primary Care</institution> and</aff><aff id="AF0004"><sup>4</sup><institution>Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>,<addr-line>Cambridge, CB1 8RN</addr-line>,<country>UK</country>,</aff><aff id="AF0005"><sup>5</sup><institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm, SE-17177</addr-line>,<country>Sweden</country>,</aff><aff id="AF0006"><sup>6</sup><institution>Copenhagen General Population Study</institution>,</aff><aff id="AF0007"><sup>7</sup><institution>Department of Clinical Biochemistry</institution>, and</aff><aff id="AF0008"><sup>8</sup><institution>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital</institution>,<addr-line>2730 Herlev</addr-line>,<country>Denmark</country>,</aff><aff id="AF0009"><sup>9</sup><institution>Vesalius Research Center, VIB</institution>,<addr-line>3000 Leuven</addr-line>,<country>Belgium</country>,</aff><aff id="AF0010"><sup>10</sup><institution>Department of Oncology, Laboratory for Translational Genetics, University of Leuven</institution>,<addr-line>3000 Leuven</addr-line>,<country>Belgium</country>,</aff><aff id="AF0011"><sup>11</sup><institution>Department of Oncology, KU Leuven (University of Leuven), Multidisciplinary Breast Center, University Hospitals Leuven</institution>,<addr-line>3000 Leuven</addr-line>,<country>Belgium</country>,</aff><aff id="AF0012"><sup>12</sup><institution>Department of Laboratory Medicine and Pathology</institution> and</aff><aff id="AF0013"><sup>13</sup><institution>Department of Health Sciences Research, Mayo Clinic</institution>,<addr-line>Rochester, MN 55905</addr-line>,<country>USA</country>,</aff><aff id="AF0014"><sup>14</sup><institution>Karmanos Cancer Institute</institution>,<addr-line>Detroit, MI 48201</addr-line>,<country>USA</country>,</aff><aff id="AF0015"><sup>15</sup><institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="AF0016"><sup>16</sup><institution>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf</institution>,<addr-line>20246 Hamburg</addr-line>,<country>Germany</country>,</aff><aff id="AF0017"><sup>17</sup><institution>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine</institution>,<country>London</country>,<addr-line>WC1E 7HT</addr-line>,<country>UK</country>,</aff><aff id="AF0018"><sup>18</sup><institution>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research</institution>,<addr-line>London, SW3 6JB</addr-line>,<country>UK</country>,</aff><aff id="AF0019"><sup>19</sup><institution>Department of Obstetrics and Gynecology</institution>,</aff><aff id="AF0020"><sup>20</sup><institution>Department of Clinical Genetics</institution> and</aff><aff id="AF0021"><sup>21</sup><institution>Department of Oncology, University of Helsinki and Helsinki University Central Hospital</institution>,<addr-line>FI-00029 Helsinki</addr-line>,<country>Finland</country>,</aff><aff id="AF0022"><sup>22</sup><institution>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital</institution>,<addr-line>1066 CX Amsterdam</addr-line>,<country>The Netherlands</country>,</aff><aff id="AF0023"><sup>23</sup><institution>Human Genetics Division, Genome Institute of Singapore</institution>,<addr-line>Singapore 138672</addr-line>,<country>Singapore</country>,</aff><aff id="AF0024"><sup>24</sup><institution>National Institute of Health and Medical Research, Center for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</aff><aff id="AF0025"><sup>25</sup><institution>University Paris-Sud</institution>,<addr-line>94807 Villejuif</addr-line>,<country>France</country>,</aff><aff id="AF0026"><sup>26</sup><institution>Department of Obstetrics and Gynecology, University of Heidelberg</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="AF0027"><sup>27</sup><institution>Molecular Epidemiology Group, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="AF0028"><sup>28</sup><institution>National Center for Tumor Diseases, University of Heidelberg</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="AF0029"><sup>29</sup><institution>Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University</institution>,<addr-line>68167 Mannheim</addr-line>,<country>Germany</country>,</aff><aff id="AF0030"><sup>30</sup><institution>Human Genotyping-CEGEN Unit</institution>and</aff><aff id="AF0031"><sup>31</sup><institution>Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)</institution>,<addr-line>28029 Madrid</addr-line>,<country>Spain</country>,</aff><aff id="AF0032"><sup>32</sup><institution>Centro de Investigación en Red de Enfermedades Raras</institution>,<addr-line>46010 Valencia</addr-line>,<country>Spain</country>,</aff><aff id="AF0033"><sup>33</sup><institution>Servicio de Oncología Médica, Hospital Universitario La Paz</institution>,<addr-line>28046 Madrid</addr-line>,<country>Spain</country>,</aff><aff id="AF0034"><sup>34</sup><institution>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco</institution>,<addr-line>33012 Oviedo</addr-line>,<country>Spain</country>,</aff><aff id="AF0035"><sup>35</sup><institution>Department of Oncology, University of Sheffield</institution>,<addr-line>Sheffield, S10 2RX</addr-line>,<country>UK</country>,</aff><aff id="AF0036"><sup>36</sup><institution>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield</institution>,<addr-line>Sheffield S10 2HQ</addr-line>,<country>UK</country>,</aff><aff id="AF0037"><sup>37</sup><institution>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto, ON M5G 1X5</addr-line>,<country>Canada</country>,</aff><aff id="AF0038"><sup>38</sup><institution>Department of Molecular Genetics, University of Toronto</institution>,<addr-line>Toronto, ON M5S 1A8</addr-line>,<country>Canada</country>,</aff><aff id="AF0039"><sup>39</sup><institution>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto, ON M5G 1X5</addr-line>,<country>Canada</country>,</aff><aff id="AF0040"><sup>40</sup><institution>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto</institution>,<addr-line>Toronto, ON M5T 3M7</addr-line>,<country>Canada</country>,</aff><aff id="AF0041"><sup>41</sup><institution>ON Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital</institution>,<addr-line>Toronto, ON, M5G 1X5</addr-line>,<country>Canada</country>,</aff><aff id="AF0042"><sup>42</sup><institution>Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital</institution>,<addr-line>London SE1 9RT</addr-line>,<country>UK</country>,</aff><aff id="AF0043"><sup>43</sup><institution>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford</institution>,<addr-line>Oxford OX3 7BN</addr-line>,<country>UK</country>,</aff><aff id="AF0044"><sup>44</sup><institution>Clinical Science Institute, University Hospital Galway</institution>,<addr-line>Galway</addr-line>,<country>Ireland</country>,</aff><aff id="AF0045"><sup>45</sup><institution>Peter MacCallum Cancer Center</institution>,<addr-line>Melbourne, Victoria 3002</addr-line>,<country>Australia</country>,</aff><aff id="AF0046"><sup>46</sup><institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane, QLD 4006</addr-line>,<country>Australia</country>,</aff><aff id="AF0047"><sup>47</sup><institution>Department of Preventive Medicine, Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA 90033</addr-line>,<country>USA</country>,</aff><aff id="AF0048"><sup>48</sup><institution>Epidemiology Program, University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI 96813</addr-line>,<country>USA</country>,</aff><aff id="AF0049"><sup>49</sup><institution>Department of Molecular Medicine and Surgery</institution> and</aff><aff id="AF0050"><sup>50</sup><institution>Department of Oncology - Pathology, Karolinska Institutet</institution>,<addr-line>Stockholm SE-17177</addr-line>,<country>Sweden</country>,</aff><aff id="AF0051"><sup>51</sup><institution>Department of Medical Oncology</institution> and</aff><aff id="AF0052"><sup>52</sup><institution>Department of Surgical Oncology, Erasmus MC Cancer Institute</institution>,<addr-line>3008 AE Rotterdam</addr-line>,<country>The Netherlands</country>,</aff><aff id="AF0053"><sup>53</sup><institution>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health</institution> and</aff><aff id="AF0054"><sup>54</sup><institution>Department of Pathology, The University of Melbourne</institution>,<addr-line>Melbourne, Victoria 3010</addr-line>,<country>Australia</country>,</aff><aff id="AF0055"><sup>55</sup><institution>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University</institution>,<addr-line>Columbus, OH 43210</addr-line>,<country>USA</country>,</aff><aff id="AF0056"><sup>56</sup><institution>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research ‘Demokritos’</institution>,<addr-line>Aghia Paraskevi Attikis, 153 10 Athens</addr-line>,<country>Greece</country>,</aff><aff id="AF0057"><sup>57</sup><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>,<addr-line>Melbourne, Victoria 3053</addr-line>,<country>Australia</country>,</aff><aff id="AF0058"><sup>58</sup><institution>Anatomical Pathology, The Alfred Hospital</institution>,<addr-line>Melbourne, Victoria 3004</addr-line>,<country>Australia</country>,</aff><aff id="AF0059"><sup>59</sup><institution>Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg</institution>,<addr-line>91054 Erlangen</addr-line>,<country>Germany</country>,</aff><aff id="AF0060"><sup>60</sup><institution>Comprehensive Cancer Center Erlangen-EMN</institution>,<addr-line>91054 Erlangen</addr-line>,<country>Germany</country>,</aff><aff id="AF0061"><sup>61</sup><institution>David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California at Los Angeles</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</aff><aff id="AF0062"><sup>62</sup><institution>Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg</institution>,<addr-line>91054 Erlangen</addr-line>,<country>Germany</country>,</aff><aff id="AF0063"><sup>63</sup><institution>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="AF0064"><sup>64</sup><institution>German Cancer Consortium (DKTK)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="AF0065"><sup>65</sup><institution>Saarland Cancer Registry</institution>,<addr-line>66119 Saarbrücken</addr-line>,<country>Germany</country>,</aff><aff id="AF0066"><sup>66</sup><institution>Division of Genetics and Epidemiology</institution> and</aff><aff id="AF0067"><sup>67</sup><institution>Division of Breast Cancer Research, Institute of Cancer Research</institution>,<addr-line>London, SM2 5NG</addr-line>,<country>UK</country>,</aff><aff id="AF0068"><sup>68</sup><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution>,<addr-line>Rockville, MD 20850</addr-line>,<country>USA</country>,</aff><aff id="AF0069"><sup>69</sup><institution>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology</institution>,<addr-line>02-781 Warsaw</addr-line>,<country>Poland</country>,</aff><aff id="AF0070"><sup>70</sup><institution>Department of Medicine, McGill University</institution>,<addr-line>Montreal, QC, H3G 2M1</addr-line>,<country>Canada</country>,</aff><aff id="AF0071"><sup>71</sup><institution>Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital</institution>,<addr-line>Montreal, QC H3G 2M1</addr-line>,<country>Canada</country>,</aff><aff id="AF0072"><sup>72</sup><institution>Département de santé environnementale et santé au travail, Département de médecine sociale et preventive, École de santé publique, Université de Montréal</institution>,<addr-line>Montreal, QC, H3T 1A8</addr-line>,<country>Canada</country>,</aff><aff id="AF0073"><sup>73</sup><institution>Centre Hospitalier Universitaire de Québec Research Center and Laval University</institution>,<addr-line>QC, G1V 4G2</addr-line>,<country>Canada</country>,</aff><aff id="AF0074"><sup>74</sup><institution>Department of Clinical Chemistry and Biocenter Oulu, Laboratory of Cancer Genetics and Tumor Biology, University of Oulu, NordLab Oulu/Oulu University Hospital</institution>,<addr-line>FI-90220 Oulu</addr-line>,<country>Finland</country>,</aff><aff id="AF0075"><sup>75</sup><institution>Department of Oncology</institution> and</aff><aff id="AF0076"><sup>76</sup><institution>Department of Surgery, Oulu University Hospital, University of Oulu</institution>,<addr-line>FI-90220 Oulu</addr-line>,<country>Finland</country>,</aff><aff id="AF0077"><sup>77</sup><institution>Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>,<addr-line>70376 Stuttgart</addr-line>,<country>Germany</country>,</aff><aff id="AF0078"><sup>78</sup><institution>University of Tübingen</institution>,<addr-line>72074 Tübingen</addr-line>,<country>Germany</country>,</aff><aff id="AF0079"><sup>79</sup><institution>German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ)</institution>,<addr-line>69120 Heidelberg</addr-line>,<country>Germany</country>,</aff><aff id="AF0080"><sup>80</sup><institution>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA)</institution>,<addr-line>44789 Bochum</addr-line>,<country>Germany</country>,</aff><aff id="AF0081"><sup>81</sup><institution>Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus</institution>,<addr-line>53113 Bonn</addr-line>,<country>Germany</country>,</aff><aff id="AF0082"><sup>82</sup><institution>Institute of Pathology, Medical Faculty of the University of Bonn</institution>,<addr-line>53127 Bonn</addr-line>,<country>Germany</country>,</aff><aff id="AF0083"><sup>83</sup><institution>Institute of Occupational Medicine and Maritime Medicine, University Medical Center Hamburg-Eppendorf</institution>,<addr-line>20246 Hamburg</addr-line>,<country>Germany</country>,</aff><aff id="AF0084"><sup>84</sup><institution>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>20133 Milan</addr-line>,<country>Italy</country>,</aff><aff id="AF0085"><sup>85</sup><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>,<addr-line>20139 Milan</addr-line>,<country>Italy</country>,</aff><aff id="AF0086"><sup>86</sup><institution>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT)</institution>,<addr-line>20133 Milan</addr-line>,<country>Italy</country>,</aff><aff id="AF0087"><sup>87</sup><institution>Cogentech Cancer Genetic Test Laboratory</institution>,<addr-line>20139 Milan</addr-line>,<country>Italy</country>,</aff><aff id="AF0088"><sup>88</sup><institution>Department of Radiation Oncology</institution> and</aff><aff id="AF0089"><sup>89</sup><institution>Department of Obstetrics and Gynaecology, Hannover Medical School</institution>,<addr-line>30625 Hannover</addr-line>,<country>Germany</country>,</aff><aff id="AF0090"><sup>90</sup><institution>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine</institution> and</aff><aff id="AF0091"><sup>91</sup><institution>Cancer Center of Eastern Finland, University of Eastern Finland</institution>,<addr-line>FI-70211 Kuopio</addr-line>,<country>Finland</country>,</aff><aff id="AF0092"><sup>92</sup><institution>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital</institution>,<addr-line>FI-70211 Kuopio</addr-line>,<country>Finland</country>,</aff><aff id="AF0093"><sup>93</sup><institution>School of Medicine, Institute of Clinical Medicine</institution>,<institution>Oncology</institution>,<institution>University of Eastern Finland</institution>,<addr-line>FI-70211 Kuopio</addr-line>,<country>Finland</country>,</aff><aff id="AF0094"><sup>94</sup><institution>Cancer Center, Kuopio University Hospital</institution>,<addr-line>FI-70210 Kuopio</addr-line>,<country>Finland</country>,</aff><aff id="AF0095"><sup>95</sup><institution>Jyväskylä Central Hospital</institution>,<addr-line>FI-40620 Jyväskylä</addr-line>,<country>Finland</country>,</aff><aff id="AF0096"><sup>96</sup><institution>Department of Human Genetics and Department of Pathology</institution>,</aff><aff id="AF0097"><sup>97</sup><institution>Department of Surgical Oncology</institution> and</aff><aff id="AF0098"><sup>98</sup><institution>Department of Clinical Genetics, Leiden University Medical Center</institution>,<addr-line>2333 ZC Leiden</addr-line>,<country>The Netherlands</country>,</aff><aff id="AF0099"><sup>99</sup><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>,<addr-line>70–115 Szczecin</addr-line>,<country>Poland</country>,</aff><aff id="AF0100"><sup>100</sup><institution>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine</institution>,<addr-line>Nashville, TN 37203</addr-line>,<country>USA</country>,</aff><aff id="AF0101"><sup>101</sup><institution>Institute of Human Genetics, Pontificia Universidad Javeriana</institution>,<addr-line>11001000 Bogotá</addr-line>,<country>Colombia</country>,</aff><aff id="AF0102"><sup>102</sup><institution>Department of Epidemiology, University of California Irvine</institution>,<addr-line>Irvine, CA 92697</addr-line>,<country>USA</country>,</aff><aff id="AF0103"><sup>103</sup><institution>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet</institution>,<addr-line>N-0310 Oslo</addr-line>,<country>Norway</country>,</aff><aff id="AF0104"><sup>104</sup><institution>Institute of Clinical Medicine, Faculty of Medicine</institution> and</aff><aff id="AF0105"><sup>105</sup><institution>Department of Clinical Molecular Biology (EpiGen), University of Oslo</institution>,<addr-line>N-0450 Oslo</addr-line>,<country>Norway</country>,</aff><aff id="AF0106"><sup>106</sup><institution>McGill University and Génome Québec Innovation Centre</institution>,<addr-line>Montréal, QC H3A 0G1</addr-line>,<country>Canada</country> and</aff><aff id="AF0107"><sup>107</sup><institution>Department of Genetics, QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane, QLD 4006</addr-line>,<country>Australia</country></aff></contrib-group><author-notes><corresp id="c2"><sup>†</sup>These authors comprise the manuscript writing group.</corresp><corresp id="c3"><sup>‡</sup>These authors comprise the manuscript writing group.</corresp><corresp id="c1">*To whom correspondence should be addressed. German Cancer Research Center (DKFZ), Molecular Genetics of Breast Cancer (B072), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany. Tel: <phone>+0049 6221 42/2344</phone>; Fax: <fax>+0049 6221 42/4721</fax>; Email: <email>u.hamann@dkfz-heidelberg.de</email></corresp></author-notes><pub-date pub-type="ppub"><month>2</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>13</day><month>1</month><year>2015</year></pub-date><volume>36</volume><issue>2</issue><fpage>256</fpage><lpage>271</lpage><history><date date-type="received"><day>20</day><month>8</month><year>2014</year></date><date date-type="rev-recd"><day>5</day><month>12</month><year>2014</year></date><date date-type="accepted"><day>25</day><month>12</month><year>2014</year></date></history><permissions><copyright-statement>© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract abstract-type="precis"><title>Summary</title><p>This is the first study investigating the contribution of inherited variants in core genes of the chromosomal passenger complex to breast cancer susceptibility. It was found that several <italic>INCENP</italic> variants are associated with the risk of ER-negative breast cancer in the European population.</p></abstract><abstract><p>The chromosomal passenger complex (CPC) plays a pivotal role in the regulation of cell division. Therefore, inherited CPC variability could influence tumor development. The present candidate gene approach investigates the relationship between single nucleotide polymorphisms (SNPs) in genes encoding key CPC components and breast cancer risk. Fifteen SNPs in four CPC genes (<italic>INCENP, AURKB</italic>, <italic>BIRC5</italic> and <italic>CDCA8</italic>) were genotyped in 88 911 European women from 39 case-control studies of the Breast Cancer Association Consortium. Possible associations were investigated in fixed-effects meta-analyses. The synonymous SNP rs1675126 in exon 7 of <italic>INCENP</italic> was associated with overall breast cancer risk [per A allele odds ratio (OR) 0.95, 95% confidence interval (CI) 0.92–0.98, <italic>P</italic> = 0.007] and particularly with estrogen receptor (ER)-negative breast tumors (per A allele OR 0.89, 95% CI 0.83–0.95, <italic>P</italic> = 0.0005). SNPs not directly genotyped were imputed based on 1000 Genomes. The SNPs rs1047739 in the 3ʹ untranslated region and rs144045115 downstream of <italic>INCENP</italic> showed the strongest association signals for overall (per T allele OR 1.03, 95% CI 1.00–1.06, <italic>P</italic> = 0.0009) and ER-negative breast cancer risk (per A allele OR 1.06, 95% CI 1.02–1.10, <italic>P</italic> = 0.0002). Two genotyped SNPs in <italic>BIRC5</italic> were associated with familial breast cancer risk (top SNP rs2071214: per G allele OR 1.12, 95% CI 1.04–1.21, <italic>P</italic> = 0.002). The data suggest that <italic>INCENP</italic> in the CPC pathway contributes to ER-negative breast cancer susceptibility in the European population. In spite of a modest contribution of CPC-inherited variants to the total burden of sporadic and familial breast cancer, their potential as novel targets for breast cancer treatment should be further investigated.</p></abstract><counts><page-count count="16"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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