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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">HLA-C expression levels define permissible mismatches in hematopoietic cell transplantation</title><author><name sortKey="Petersdorf, Effie W" sort="Petersdorf, Effie W" uniqKey="Petersdorf E" first="Effie W." last="Petersdorf">Effie W. Petersdorf</name><affiliation><nlm:aff id="aff1">Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Medicine, University of Washington School of Medicine, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Gooley, Theodore A" sort="Gooley, Theodore A" uniqKey="Gooley T" first="Theodore A." last="Gooley">Theodore A. Gooley</name><affiliation><nlm:aff id="aff1">Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Malkki, Mari" sort="Malkki, Mari" uniqKey="Malkki M" first="Mari" last="Malkki">Mari Malkki</name><affiliation><nlm:aff id="aff1">Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Bacigalupo, Andrea P" sort="Bacigalupo, Andrea P" uniqKey="Bacigalupo A" first="Andrea P." last="Bacigalupo">Andrea P. Bacigalupo</name><affiliation><nlm:aff id="aff3">Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria San Martino, Genova, Italy;</nlm:aff></affiliation></author><author><name sortKey="Cesbron, Anne" sort="Cesbron, Anne" uniqKey="Cesbron A" first="Anne" last="Cesbron">Anne Cesbron</name><affiliation><nlm:aff id="aff4">Laboratoire d'Histocompatibilité et d'Immunogénétique, Etablissement Français du Sang Pays de Loire, Nantes, France;</nlm:aff></affiliation></author><author><name sortKey="Du Toit, Ernette" sort="Du Toit, Ernette" uniqKey="Du Toit E" first="Ernette" last="Du Toit">Ernette Du Toit</name><affiliation><nlm:aff id="aff5">University of Cape Town, Cape Town and South African Bone Marrow Registry, Cape Town, South Africa;</nlm:aff></affiliation></author><author><name sortKey="Ehninger, Gerhard" sort="Ehninger, Gerhard" uniqKey="Ehninger G" first="Gerhard" last="Ehninger">Gerhard Ehninger</name><affiliation><nlm:aff id="aff6">Universitätsklinikum Carl Gustav Carus, Dresden, Germany;</nlm:aff></affiliation></author><author><name sortKey="Egeland, Torstein" sort="Egeland, Torstein" uniqKey="Egeland T" first="Torstein" last="Egeland">Torstein Egeland</name><affiliation><nlm:aff id="aff7">Department of Immunology, Oslo University Hospital, Oslo, Norway;</nlm:aff></affiliation></author><author><name sortKey="Fischer, Gottfried F" sort="Fischer, Gottfried F" uniqKey="Fischer G" first="Gottfried F." last="Fischer">Gottfried F. Fischer</name><affiliation><nlm:aff id="aff8">Department for Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria;</nlm:aff></affiliation></author><author><name sortKey="Gervais, Thibaut" sort="Gervais, Thibaut" uniqKey="Gervais T" first="Thibaut" last="Gervais">Thibaut Gervais</name><affiliation><nlm:aff id="aff9">Cliniques St. Luc, Université Catholique de Louvain, Brussels, Belgium;</nlm:aff></affiliation></author><author><name sortKey="Haagenson, Michael D" sort="Haagenson, Michael D" uniqKey="Haagenson M" first="Michael D." last="Haagenson">Michael D. Haagenson</name><affiliation><nlm:aff id="aff10">Center for International Blood and Marrow Transplant Research, Minneapolis, MN;</nlm:aff></affiliation></author><author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name><affiliation><nlm:aff id="aff11">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI;</nlm:aff></affiliation></author><author><name sortKey="Hsu, Katharine" sort="Hsu, Katharine" uniqKey="Hsu K" first="Katharine" last="Hsu">Katharine Hsu</name><affiliation><nlm:aff id="aff12">Memorial Sloan-Kettering Cancer Center, New York, NY;</nlm:aff></affiliation></author><author><name sortKey="Jindra, Pavel" sort="Jindra, Pavel" uniqKey="Jindra P" first="Pavel" last="Jindra">Pavel Jindra</name><affiliation><nlm:aff id="aff13">University Hospital, Pilsen, Czech Republic;</nlm:aff></affiliation></author><author><name sortKey="Madrigal, Alejandro" sort="Madrigal, Alejandro" uniqKey="Madrigal A" first="Alejandro" last="Madrigal">Alejandro Madrigal</name><affiliation><nlm:aff id="aff14">Anthony Nolan Research Institute, The Royal Free Hampstead NHS Trust, London, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Oudshoorn, Machteld" sort="Oudshoorn, Machteld" uniqKey="Oudshoorn M" first="Machteld" last="Oudshoorn">Machteld Oudshoorn</name><affiliation><nlm:aff id="aff15">Leiden University Medical Center and Europdonor Foundation, Leiden, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Ringden, Olle" sort="Ringden, Olle" uniqKey="Ringden O" first="Olle" last="Ringdén">Olle Ringdén</name><affiliation><nlm:aff id="aff16">Division of Therapeutic Immunology, Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Huddinge, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Schroeder, Marlis L" sort="Schroeder, Marlis L" uniqKey="Schroeder M" first="Marlis L." last="Schroeder">Marlis L. Schroeder</name><affiliation><nlm:aff id="aff17">Cancer Care Manitoba, University of Manitoba, Winnipeg, MB, Canada;</nlm:aff></affiliation></author><author><name sortKey="Spellman, Stephen R" sort="Spellman, Stephen R" uniqKey="Spellman S" first="Stephen R." last="Spellman">Stephen R. Spellman</name><affiliation><nlm:aff id="aff10">Center for International Blood and Marrow Transplant Research, Minneapolis, MN;</nlm:aff></affiliation></author><author><name sortKey="Tiercy, Jean Marie" sort="Tiercy, Jean Marie" uniqKey="Tiercy J" first="Jean-Marie" last="Tiercy">Jean-Marie Tiercy</name><affiliation><nlm:aff id="aff18">National Reference Laboratory for Histocompatibility, Department of Genetics and Laboratory Medicine, University Hospital Geneva, Geneva, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Velardi, Andrea" sort="Velardi, Andrea" uniqKey="Velardi A" first="Andrea" last="Velardi">Andrea Velardi</name><affiliation><nlm:aff id="aff19">European Group for Blood and Marrow Transplantation and University of Perugia, Perugia, Italy;</nlm:aff></affiliation></author><author><name sortKey="Witt, Campbell S" sort="Witt, Campbell S" uniqKey="Witt C" first="Campbell S." last="Witt">Campbell S. Witt</name><affiliation><nlm:aff id="aff20">Department of Clinical Immunology, Royal Perth Hospital, Perth, Australia;</nlm:aff></affiliation></author><author><name sortKey="O Uigin, Colm" sort="O Uigin, Colm" uniqKey="O Uigin C" first="Colm" last="O Uigin">Colm O Uigin</name><affiliation><nlm:aff wicri:cut="; and" id="aff21">Cancer and Inflammation Program, SAIC Frederick, Inc., Frederick National Laboratories for Cancer Research, Frederick, MD</nlm:aff></affiliation></author><author><name sortKey="Apps, Richard" sort="Apps, Richard" uniqKey="Apps R" first="Richard" last="Apps">Richard Apps</name><affiliation><nlm:aff wicri:cut="; and" id="aff21">Cancer and Inflammation Program, SAIC Frederick, Inc., Frederick National Laboratories for Cancer Research, Frederick, MD</nlm:aff></affiliation><affiliation><nlm:aff id="aff22">Ragon Institute of the Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Carrington, Mary" sort="Carrington, Mary" uniqKey="Carrington M" first="Mary" last="Carrington">Mary Carrington</name><affiliation><nlm:aff wicri:cut="; and" id="aff21">Cancer and Inflammation Program, SAIC Frederick, Inc., Frederick National Laboratories for Cancer Research, Frederick, MD</nlm:aff></affiliation><affiliation><nlm:aff id="aff22">Ragon Institute of the Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25323824</idno><idno type="pmc">4271183</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271183</idno><idno type="RBID">PMC:4271183</idno><idno type="doi">10.1182/blood-2014-09-599969</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001805</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001805</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">HLA-C expression levels define permissible mismatches in hematopoietic cell transplantation</title><author><name sortKey="Petersdorf, Effie W" sort="Petersdorf, Effie W" uniqKey="Petersdorf E" first="Effie W." last="Petersdorf">Effie W. Petersdorf</name><affiliation><nlm:aff id="aff1">Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Medicine, University of Washington School of Medicine, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Gooley, Theodore A" sort="Gooley, Theodore A" uniqKey="Gooley T" first="Theodore A." last="Gooley">Theodore A. Gooley</name><affiliation><nlm:aff id="aff1">Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Malkki, Mari" sort="Malkki, Mari" uniqKey="Malkki M" first="Mari" last="Malkki">Mari Malkki</name><affiliation><nlm:aff id="aff1">Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Bacigalupo, Andrea P" sort="Bacigalupo, Andrea P" uniqKey="Bacigalupo A" first="Andrea P." last="Bacigalupo">Andrea P. Bacigalupo</name><affiliation><nlm:aff id="aff3">Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria San Martino, Genova, Italy;</nlm:aff></affiliation></author><author><name sortKey="Cesbron, Anne" sort="Cesbron, Anne" uniqKey="Cesbron A" first="Anne" last="Cesbron">Anne Cesbron</name><affiliation><nlm:aff id="aff4">Laboratoire d'Histocompatibilité et d'Immunogénétique, Etablissement Français du Sang Pays de Loire, Nantes, France;</nlm:aff></affiliation></author><author><name sortKey="Du Toit, Ernette" sort="Du Toit, Ernette" uniqKey="Du Toit E" first="Ernette" last="Du Toit">Ernette Du Toit</name><affiliation><nlm:aff id="aff5">University of Cape Town, Cape Town and South African Bone Marrow Registry, Cape Town, South Africa;</nlm:aff></affiliation></author><author><name sortKey="Ehninger, Gerhard" sort="Ehninger, Gerhard" uniqKey="Ehninger G" first="Gerhard" last="Ehninger">Gerhard Ehninger</name><affiliation><nlm:aff id="aff6">Universitätsklinikum Carl Gustav Carus, Dresden, Germany;</nlm:aff></affiliation></author><author><name sortKey="Egeland, Torstein" sort="Egeland, Torstein" uniqKey="Egeland T" first="Torstein" last="Egeland">Torstein Egeland</name><affiliation><nlm:aff id="aff7">Department of Immunology, Oslo University Hospital, Oslo, Norway;</nlm:aff></affiliation></author><author><name sortKey="Fischer, Gottfried F" sort="Fischer, Gottfried F" uniqKey="Fischer G" first="Gottfried F." last="Fischer">Gottfried F. Fischer</name><affiliation><nlm:aff id="aff8">Department for Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria;</nlm:aff></affiliation></author><author><name sortKey="Gervais, Thibaut" sort="Gervais, Thibaut" uniqKey="Gervais T" first="Thibaut" last="Gervais">Thibaut Gervais</name><affiliation><nlm:aff id="aff9">Cliniques St. Luc, Université Catholique de Louvain, Brussels, Belgium;</nlm:aff></affiliation></author><author><name sortKey="Haagenson, Michael D" sort="Haagenson, Michael D" uniqKey="Haagenson M" first="Michael D." last="Haagenson">Michael D. Haagenson</name><affiliation><nlm:aff id="aff10">Center for International Blood and Marrow Transplant Research, Minneapolis, MN;</nlm:aff></affiliation></author><author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name><affiliation><nlm:aff id="aff11">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI;</nlm:aff></affiliation></author><author><name sortKey="Hsu, Katharine" sort="Hsu, Katharine" uniqKey="Hsu K" first="Katharine" last="Hsu">Katharine Hsu</name><affiliation><nlm:aff id="aff12">Memorial Sloan-Kettering Cancer Center, New York, NY;</nlm:aff></affiliation></author><author><name sortKey="Jindra, Pavel" sort="Jindra, Pavel" uniqKey="Jindra P" first="Pavel" last="Jindra">Pavel Jindra</name><affiliation><nlm:aff id="aff13">University Hospital, Pilsen, Czech Republic;</nlm:aff></affiliation></author><author><name sortKey="Madrigal, Alejandro" sort="Madrigal, Alejandro" uniqKey="Madrigal A" first="Alejandro" last="Madrigal">Alejandro Madrigal</name><affiliation><nlm:aff id="aff14">Anthony Nolan Research Institute, The Royal Free Hampstead NHS Trust, London, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Oudshoorn, Machteld" sort="Oudshoorn, Machteld" uniqKey="Oudshoorn M" first="Machteld" last="Oudshoorn">Machteld Oudshoorn</name><affiliation><nlm:aff id="aff15">Leiden University Medical Center and Europdonor Foundation, Leiden, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Ringden, Olle" sort="Ringden, Olle" uniqKey="Ringden O" first="Olle" last="Ringdén">Olle Ringdén</name><affiliation><nlm:aff id="aff16">Division of Therapeutic Immunology, Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Huddinge, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Schroeder, Marlis L" sort="Schroeder, Marlis L" uniqKey="Schroeder M" first="Marlis L." last="Schroeder">Marlis L. Schroeder</name><affiliation><nlm:aff id="aff17">Cancer Care Manitoba, University of Manitoba, Winnipeg, MB, Canada;</nlm:aff></affiliation></author><author><name sortKey="Spellman, Stephen R" sort="Spellman, Stephen R" uniqKey="Spellman S" first="Stephen R." last="Spellman">Stephen R. Spellman</name><affiliation><nlm:aff id="aff10">Center for International Blood and Marrow Transplant Research, Minneapolis, MN;</nlm:aff></affiliation></author><author><name sortKey="Tiercy, Jean Marie" sort="Tiercy, Jean Marie" uniqKey="Tiercy J" first="Jean-Marie" last="Tiercy">Jean-Marie Tiercy</name><affiliation><nlm:aff id="aff18">National Reference Laboratory for Histocompatibility, Department of Genetics and Laboratory Medicine, University Hospital Geneva, Geneva, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Velardi, Andrea" sort="Velardi, Andrea" uniqKey="Velardi A" first="Andrea" last="Velardi">Andrea Velardi</name><affiliation><nlm:aff id="aff19">European Group for Blood and Marrow Transplantation and University of Perugia, Perugia, Italy;</nlm:aff></affiliation></author><author><name sortKey="Witt, Campbell S" sort="Witt, Campbell S" uniqKey="Witt C" first="Campbell S." last="Witt">Campbell S. Witt</name><affiliation><nlm:aff id="aff20">Department of Clinical Immunology, Royal Perth Hospital, Perth, Australia;</nlm:aff></affiliation></author><author><name sortKey="O Uigin, Colm" sort="O Uigin, Colm" uniqKey="O Uigin C" first="Colm" last="O Uigin">Colm O Uigin</name><affiliation><nlm:aff wicri:cut="; and" id="aff21">Cancer and Inflammation Program, SAIC Frederick, Inc., Frederick National Laboratories for Cancer Research, Frederick, MD</nlm:aff></affiliation></author><author><name sortKey="Apps, Richard" sort="Apps, Richard" uniqKey="Apps R" first="Richard" last="Apps">Richard Apps</name><affiliation><nlm:aff wicri:cut="; and" id="aff21">Cancer and Inflammation Program, SAIC Frederick, Inc., Frederick National Laboratories for Cancer Research, Frederick, MD</nlm:aff></affiliation><affiliation><nlm:aff id="aff22">Ragon Institute of the Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Carrington, Mary" sort="Carrington, Mary" uniqKey="Carrington M" first="Mary" last="Carrington">Mary Carrington</name><affiliation><nlm:aff wicri:cut="; and" id="aff21">Cancer and Inflammation Program, SAIC Frederick, Inc., Frederick National Laboratories for Cancer Research, Frederick, MD</nlm:aff></affiliation><affiliation><nlm:aff id="aff22">Ragon Institute of the Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA</nlm:aff></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Key Points</title><p><list list-type="bullet"><list-item><p>The expression level of patient HLA-C allotypes affects GVHD and mortality after HCT from HLA-C-mismatched unrelated donors.</p></list-item><list-item><p>Transplant outcome can be improved by avoiding high-risk HLA-C-mismatched donors when no matched stem cell source is available.</p></list-item></list></p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id><journal-id journal-id-type="iso-abbrev">Blood</journal-id><journal-id journal-id-type="hwp">bloodjournal</journal-id><journal-id journal-id-type="pmc">blood</journal-id><journal-id journal-id-type="publisher-id">Blood</journal-id><journal-title-group><journal-title>Blood</journal-title></journal-title-group><issn pub-type="ppub">0006-4971</issn><issn pub-type="epub">1528-0020</issn><publisher><publisher-name>American Society of Hematology</publisher-name><publisher-loc>Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25323824</article-id><article-id pub-id-type="pmc">4271183</article-id><article-id pub-id-type="publisher-id">2014/599969</article-id><article-id pub-id-type="doi">10.1182/blood-2014-09-599969</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>17</subject></subj-group><subj-group subj-group-type="heading"><subject>Transplantation</subject></subj-group></article-categories><title-group><article-title>HLA-C expression levels define permissible mismatches in hematopoietic cell transplantation</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Petersdorf</surname><given-names>Effie W.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Gooley</surname><given-names>Theodore A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Malkki</surname><given-names>Mari</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bacigalupo</surname><given-names>Andrea P.</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Cesbron</surname><given-names>Anne</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Du Toit</surname><given-names>Ernette</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Ehninger</surname><given-names>Gerhard</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Egeland</surname><given-names>Torstein</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Fischer</surname><given-names>Gottfried F.</given-names></name><xref ref-type="aff" rid="aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>Gervais</surname><given-names>Thibaut</given-names></name><xref ref-type="aff" rid="aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Haagenson</surname><given-names>Michael D.</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Horowitz</surname><given-names>Mary M.</given-names></name><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Hsu</surname><given-names>Katharine</given-names></name><xref ref-type="aff" rid="aff12">12</xref></contrib><contrib contrib-type="author"><name><surname>Jindra</surname><given-names>Pavel</given-names></name><xref ref-type="aff" rid="aff13">13</xref></contrib><contrib contrib-type="author"><name><surname>Madrigal</surname><given-names>Alejandro</given-names></name><xref ref-type="aff" rid="aff14">14</xref></contrib><contrib contrib-type="author"><name><surname>Oudshoorn</surname><given-names>Machteld</given-names></name><xref ref-type="aff" rid="aff15">15</xref></contrib><contrib contrib-type="author"><name><surname>Ringdén</surname><given-names>Olle</given-names></name><xref ref-type="aff" rid="aff16">16</xref></contrib><contrib contrib-type="author"><name><surname>Schroeder</surname><given-names>Marlis L.</given-names></name><xref ref-type="aff" rid="aff17">17</xref></contrib><contrib contrib-type="author"><name><surname>Spellman</surname><given-names>Stephen R.</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Tiercy</surname><given-names>Jean-Marie</given-names></name><xref ref-type="aff" rid="aff18">18</xref></contrib><contrib contrib-type="author"><name><surname>Velardi</surname><given-names>Andrea</given-names></name><xref ref-type="aff" rid="aff19">19</xref></contrib><contrib contrib-type="author"><name><surname>Witt</surname><given-names>Campbell S.</given-names></name><xref ref-type="aff" rid="aff20">20</xref></contrib><contrib contrib-type="author"><name><surname>O’Huigin</surname><given-names>Colm</given-names></name><xref ref-type="aff" rid="aff21">21</xref></contrib><contrib contrib-type="author"><name><surname>Apps</surname><given-names>Richard</given-names></name><xref ref-type="aff" rid="aff21">21</xref><xref ref-type="aff" rid="aff22">22</xref></contrib><contrib contrib-type="author"><name><surname>Carrington</surname><given-names>Mary</given-names></name><xref ref-type="aff" rid="aff21">21</xref><xref ref-type="aff" rid="aff22">22</xref></contrib><on-behalf-of>for the International Histocompatibility Working Group in Hematopoietic Cell Transplantation</on-behalf-of><aff id="aff1"><label>1</label>Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA;</aff><aff id="aff2"><label>2</label>Department of Medicine, University of Washington School of Medicine, Seattle, WA;</aff><aff id="aff3"><label>3</label>Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria San Martino, Genova, Italy;</aff><aff id="aff4"><label>4</label>Laboratoire d'Histocompatibilité et d'Immunogénétique, Etablissement Français du Sang Pays de Loire, Nantes, France;</aff><aff id="aff5"><label>5</label>University of Cape Town, Cape Town and South African Bone Marrow Registry, Cape Town, South Africa;</aff><aff id="aff6"><label>6</label>Universitätsklinikum Carl Gustav Carus, Dresden, Germany;</aff><aff id="aff7"><label>7</label>Department of Immunology, Oslo University Hospital, Oslo, Norway;</aff><aff id="aff8"><label>8</label>Department for Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria;</aff><aff id="aff9"><label>9</label>Cliniques St. Luc, Université Catholique de Louvain, Brussels, Belgium;</aff><aff id="aff10"><label>10</label>Center for International Blood and Marrow Transplant Research, Minneapolis, MN;</aff><aff id="aff11"><label>11</label>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI;</aff><aff id="aff12"><label>12</label>Memorial Sloan-Kettering Cancer Center, New York, NY;</aff><aff id="aff13"><label>13</label>University Hospital, Pilsen, Czech Republic;</aff><aff id="aff14"><label>14</label>Anthony Nolan Research Institute, The Royal Free Hampstead NHS Trust, London, United Kingdom;</aff><aff id="aff15"><label>15</label>Leiden University Medical Center and Europdonor Foundation, Leiden, The Netherlands;</aff><aff id="aff16"><label>16</label>Division of Therapeutic Immunology, Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Huddinge, Sweden;</aff><aff id="aff17"><label>17</label>Cancer Care Manitoba, University of Manitoba, Winnipeg, MB, Canada;</aff><aff id="aff18"><label>18</label>National Reference Laboratory for Histocompatibility, Department of Genetics and Laboratory Medicine, University Hospital Geneva, Geneva, Switzerland;</aff><aff id="aff19"><label>19</label>European Group for Blood and Marrow Transplantation and University of Perugia, Perugia, Italy;</aff><aff id="aff20"><label>20</label>Department of Clinical Immunology, Royal Perth Hospital, Perth, Australia;</aff><aff id="aff21"><label>21</label>Cancer and Inflammation Program, SAIC Frederick, Inc., Frederick National Laboratories for Cancer Research, Frederick, MD; and</aff><aff id="aff22"><label>22</label>Ragon Institute of the Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA</aff></contrib-group><pub-date pub-type="ppub"><day>18</day><month>12</month><year>2014</year></pub-date><pub-date pub-type="epreprint"><day>16</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>18</day><month>12</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>124</volume><issue>26</issue><fpage>3996</fpage><lpage>4003</lpage><history><date date-type="received"><day>08</day><month>9</month><year>2014</year></date><date date-type="accepted"><day>03</day><month>10</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 by The American Society of Hematology</copyright-statement><copyright-year>2014</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="3996.pdf"></self-uri><related-article id="d35e383" related-article-type="article-reference" ext-link-type="doi" xlink:href="10.1182/blood-2014-10-607853">Fernández-Viña</related-article><abstract abstract-type="executive-summary"><title>Key Points</title><p><list list-type="bullet"><list-item><p>The expression level of patient HLA-C allotypes affects GVHD and mortality after HCT from HLA-C-mismatched unrelated donors.</p></list-item><list-item><p>Transplant outcome can be improved by avoiding high-risk HLA-C-mismatched donors when no matched stem cell source is available.</p></list-item></list></p></abstract><abstract><p>Life-threatening graft-versus-host disease (GVHD) limits the use of HLA-C-mismatched unrelated donors in transplantation. Clinicians lack criteria for donor selection when HLA-C-mismatched donors are a patient’s only option for cure. We examined the role for HLA-C expression levels to identify permissible HLA-C mismatches. The median fluorescence intensity, a proxy of HLA-C expression, was assigned to each HLA-C allotype in 1975 patients and their HLA-C-mismatched unrelated transplant donors. The association of outcome with the level of expression of patients’ and donors’ HLA-C allotypes was evaluated in multivariable models. Increasing expression level of the patient’s mismatched HLA-C allotype was associated with increased risks of grades III to IV acute GVHD, nonrelapse mortality, and mortality. Increasing expression level among HLA-C mismatches with residue 116 or residue 77/80 mismatching was associated with increased nonrelapse mortality. The immunogenicity of HLA-C mismatches in unrelated donor transplantation is influenced by the expression level of the patient’s mismatched HLA-C allotype. HLA-C expression levels provide new information on mismatches that should be avoided and extend understanding of HLA-C-mediated immune responses in human disease.</p></abstract><funding-group><award-group><funding-source id="CS100">National Institutes of Health</funding-source></award-group></funding-group><counts><page-count count="8"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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