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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">IL-21 signalling via STAT3 primes human naïve B cells to respond to IL-2 to enhance their differentiation into plasmablasts</title>
<author><name sortKey="Berglund, Lucinda J" sort="Berglund, Lucinda J" uniqKey="Berglund L" first="Lucinda J." last="Berglund">Lucinda J. Berglund</name>
<affiliation><nlm:aff id="aff1">Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">St Vincent’s Clinical School, University of New South Wales, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Department of Immunology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Avery, Danielle T" sort="Avery, Danielle T" uniqKey="Avery D" first="Danielle T." last="Avery">Danielle T. Avery</name>
<affiliation><nlm:aff id="aff1">Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ma, Cindy S" sort="Ma, Cindy S" uniqKey="Ma C" first="Cindy S." last="Ma">Cindy S. Ma</name>
<affiliation><nlm:aff id="aff1">Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">St Vincent’s Clinical School, University of New South Wales, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Moens, Leen" sort="Moens, Leen" uniqKey="Moens L" first="Leen" last="Moens">Leen Moens</name>
<affiliation><nlm:aff id="aff1">Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Deenick, Elissa K" sort="Deenick, Elissa K" uniqKey="Deenick E" first="Elissa K." last="Deenick">Elissa K. Deenick</name>
<affiliation><nlm:aff id="aff1">Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">St Vincent’s Clinical School, University of New South Wales, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bustamante, Jacinta" sort="Bustamante, Jacinta" uniqKey="Bustamante J" first="Jacinta" last="Bustamante">Jacinta Bustamante</name>
<affiliation><nlm:aff id="aff4">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U980, Necker Medical School, University Paris Descartes, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Study Center for Primary Immunodeficiencies, AP-HP, Necker Hospital, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff6">Université Paris Descartes, Institut Imagine, Paris, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Boisson Dupuis, Stephanie" sort="Boisson Dupuis, Stephanie" uniqKey="Boisson Dupuis S" first="Stephanie" last="Boisson-Dupuis">Stephanie Boisson-Dupuis</name>
<affiliation><nlm:aff id="aff4">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U980, Necker Medical School, University Paris Descartes, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff7">Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wong, Melanie" sort="Wong, Melanie" uniqKey="Wong M" first="Melanie" last="Wong">Melanie Wong</name>
<affiliation><nlm:aff id="aff8">Department of Immunology, Children’s Hospital at Westmead, Westmead, NSW, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Adelstein, Stephen" sort="Adelstein, Stephen" uniqKey="Adelstein S" first="Stephen" last="Adelstein">Stephen Adelstein</name>
<affiliation><nlm:aff id="aff9">Clinical Immunology, Royal Prince Alfred Hospital, Sydney, NSW, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Arkwright, Peter D" sort="Arkwright, Peter D" uniqKey="Arkwright P" first="Peter D." last="Arkwright">Peter D. Arkwright</name>
<affiliation><nlm:aff id="aff10">University of Manchester, Royal Manchester Children’s Hospital, Manchester, United Kingdom;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bacchetta, Rosa" sort="Bacchetta, Rosa" uniqKey="Bacchetta R" first="Rosa" last="Bacchetta">Rosa Bacchetta</name>
<affiliation><nlm:aff id="aff11">San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), San Raffaele Scientific Institute, Milan, Italy;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bezrodnik, Liliana" sort="Bezrodnik, Liliana" uniqKey="Bezrodnik L" first="Liliana" last="Bezrodnik">Liliana Bezrodnik</name>
<affiliation><nlm:aff id="aff12">Immunology Unit, Ricardo Gutiérrez Children Hosptial, Ciudad Autónoma de Buenos Aires, Argentina;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dadi, Harjit" sort="Dadi, Harjit" uniqKey="Dadi H" first="Harjit" last="Dadi">Harjit Dadi</name>
<affiliation><nlm:aff id="aff13">Canadian Centre for Primary Immunodeficiency, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Roifman, Chaim M" sort="Roifman, Chaim M" uniqKey="Roifman C" first="Chaim M." last="Roifman">Chaim M. Roifman</name>
<affiliation><nlm:aff id="aff13">Canadian Centre for Primary Immunodeficiency, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fulcher, David A" sort="Fulcher, David A" uniqKey="Fulcher D" first="David A." last="Fulcher">David A. Fulcher</name>
<affiliation><nlm:aff id="aff3">Department of Immunology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ziegler, John B" sort="Ziegler, John B" uniqKey="Ziegler J" first="John B." last="Ziegler">John B. Ziegler</name>
<affiliation><nlm:aff id="aff14">Department of Immunology, Sydney Children's Hospital, Randwick, NSW, Australia and School of Women’s and Children’s Health, University of NSW, Randwick, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Smart, Joanne M" sort="Smart, Joanne M" uniqKey="Smart J" first="Joanne M." last="Smart">Joanne M. Smart</name>
<affiliation><nlm:aff id="aff15">Department of Allergy and Immunology, Royal Children’s Hospital Melbourne, Melbourne, VIC, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kobayashi, Masao" sort="Kobayashi, Masao" uniqKey="Kobayashi M" first="Masao" last="Kobayashi">Masao Kobayashi</name>
<affiliation><nlm:aff id="aff16">Department of Pediatrics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name>
<affiliation><nlm:aff id="aff4">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U980, Necker Medical School, University Paris Descartes, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Study Center for Primary Immunodeficiencies, AP-HP, Necker Hospital, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff6">Université Paris Descartes, Institut Imagine, Paris, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Durandy, Anne" sort="Durandy, Anne" uniqKey="Durandy A" first="Anne" last="Durandy">Anne Durandy</name>
<affiliation><nlm:aff id="aff5">Study Center for Primary Immunodeficiencies, AP-HP, Necker Hospital, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff6">Université Paris Descartes, Institut Imagine, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff17">INSERM, Unité U768, Hôpital Necker Enfants-Malades, Paris, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cook, Matthew C" sort="Cook, Matthew C" uniqKey="Cook M" first="Matthew C." last="Cook">Matthew C. Cook</name>
<affiliation><nlm:aff wicri:cut=", and" id="aff18">Australian National University Medical School</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff19">John Curtin School of Medical Research, Australian National University, ACT, Canberra, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut="; and" id="aff20">Department of Immunology, The Canberra Hospital, Canberra, ACT, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name>
<affiliation><nlm:aff id="aff4">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U980, Necker Medical School, University Paris Descartes, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff6">Université Paris Descartes, Institut Imagine, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff7">Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Uzel, Gulbu" sort="Uzel, Gulbu" uniqKey="Uzel G" first="Gulbu" last="Uzel">Gulbu Uzel</name>
<affiliation><nlm:aff id="aff21">Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tangye, Stuart G" sort="Tangye, Stuart G" uniqKey="Tangye S" first="Stuart G." last="Tangye">Stuart G. Tangye</name>
<affiliation><nlm:aff id="aff1">Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">St Vincent’s Clinical School, University of New South Wales, Australia;</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24159173</idno>
<idno type="pmc">3854113</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854113</idno>
<idno type="RBID">PMC:3854113</idno>
<idno type="doi">10.1182/blood-2013-06-506865</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">001801</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001801</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">IL-21 signalling via STAT3 primes human naïve B cells to respond to IL-2 to enhance their differentiation into plasmablasts</title>
<author><name sortKey="Berglund, Lucinda J" sort="Berglund, Lucinda J" uniqKey="Berglund L" first="Lucinda J." last="Berglund">Lucinda J. Berglund</name>
<affiliation><nlm:aff id="aff1">Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">St Vincent’s Clinical School, University of New South Wales, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Department of Immunology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Avery, Danielle T" sort="Avery, Danielle T" uniqKey="Avery D" first="Danielle T." last="Avery">Danielle T. Avery</name>
<affiliation><nlm:aff id="aff1">Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ma, Cindy S" sort="Ma, Cindy S" uniqKey="Ma C" first="Cindy S." last="Ma">Cindy S. Ma</name>
<affiliation><nlm:aff id="aff1">Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">St Vincent’s Clinical School, University of New South Wales, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Moens, Leen" sort="Moens, Leen" uniqKey="Moens L" first="Leen" last="Moens">Leen Moens</name>
<affiliation><nlm:aff id="aff1">Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Deenick, Elissa K" sort="Deenick, Elissa K" uniqKey="Deenick E" first="Elissa K." last="Deenick">Elissa K. Deenick</name>
<affiliation><nlm:aff id="aff1">Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">St Vincent’s Clinical School, University of New South Wales, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bustamante, Jacinta" sort="Bustamante, Jacinta" uniqKey="Bustamante J" first="Jacinta" last="Bustamante">Jacinta Bustamante</name>
<affiliation><nlm:aff id="aff4">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U980, Necker Medical School, University Paris Descartes, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Study Center for Primary Immunodeficiencies, AP-HP, Necker Hospital, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff6">Université Paris Descartes, Institut Imagine, Paris, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Boisson Dupuis, Stephanie" sort="Boisson Dupuis, Stephanie" uniqKey="Boisson Dupuis S" first="Stephanie" last="Boisson-Dupuis">Stephanie Boisson-Dupuis</name>
<affiliation><nlm:aff id="aff4">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U980, Necker Medical School, University Paris Descartes, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff7">Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wong, Melanie" sort="Wong, Melanie" uniqKey="Wong M" first="Melanie" last="Wong">Melanie Wong</name>
<affiliation><nlm:aff id="aff8">Department of Immunology, Children’s Hospital at Westmead, Westmead, NSW, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Adelstein, Stephen" sort="Adelstein, Stephen" uniqKey="Adelstein S" first="Stephen" last="Adelstein">Stephen Adelstein</name>
<affiliation><nlm:aff id="aff9">Clinical Immunology, Royal Prince Alfred Hospital, Sydney, NSW, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Arkwright, Peter D" sort="Arkwright, Peter D" uniqKey="Arkwright P" first="Peter D." last="Arkwright">Peter D. Arkwright</name>
<affiliation><nlm:aff id="aff10">University of Manchester, Royal Manchester Children’s Hospital, Manchester, United Kingdom;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bacchetta, Rosa" sort="Bacchetta, Rosa" uniqKey="Bacchetta R" first="Rosa" last="Bacchetta">Rosa Bacchetta</name>
<affiliation><nlm:aff id="aff11">San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), San Raffaele Scientific Institute, Milan, Italy;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bezrodnik, Liliana" sort="Bezrodnik, Liliana" uniqKey="Bezrodnik L" first="Liliana" last="Bezrodnik">Liliana Bezrodnik</name>
<affiliation><nlm:aff id="aff12">Immunology Unit, Ricardo Gutiérrez Children Hosptial, Ciudad Autónoma de Buenos Aires, Argentina;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dadi, Harjit" sort="Dadi, Harjit" uniqKey="Dadi H" first="Harjit" last="Dadi">Harjit Dadi</name>
<affiliation><nlm:aff id="aff13">Canadian Centre for Primary Immunodeficiency, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Roifman, Chaim M" sort="Roifman, Chaim M" uniqKey="Roifman C" first="Chaim M." last="Roifman">Chaim M. Roifman</name>
<affiliation><nlm:aff id="aff13">Canadian Centre for Primary Immunodeficiency, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fulcher, David A" sort="Fulcher, David A" uniqKey="Fulcher D" first="David A." last="Fulcher">David A. Fulcher</name>
<affiliation><nlm:aff id="aff3">Department of Immunology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ziegler, John B" sort="Ziegler, John B" uniqKey="Ziegler J" first="John B." last="Ziegler">John B. Ziegler</name>
<affiliation><nlm:aff id="aff14">Department of Immunology, Sydney Children's Hospital, Randwick, NSW, Australia and School of Women’s and Children’s Health, University of NSW, Randwick, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Smart, Joanne M" sort="Smart, Joanne M" uniqKey="Smart J" first="Joanne M." last="Smart">Joanne M. Smart</name>
<affiliation><nlm:aff id="aff15">Department of Allergy and Immunology, Royal Children’s Hospital Melbourne, Melbourne, VIC, Australia;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kobayashi, Masao" sort="Kobayashi, Masao" uniqKey="Kobayashi M" first="Masao" last="Kobayashi">Masao Kobayashi</name>
<affiliation><nlm:aff id="aff16">Department of Pediatrics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name>
<affiliation><nlm:aff id="aff4">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U980, Necker Medical School, University Paris Descartes, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Study Center for Primary Immunodeficiencies, AP-HP, Necker Hospital, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff6">Université Paris Descartes, Institut Imagine, Paris, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Durandy, Anne" sort="Durandy, Anne" uniqKey="Durandy A" first="Anne" last="Durandy">Anne Durandy</name>
<affiliation><nlm:aff id="aff5">Study Center for Primary Immunodeficiencies, AP-HP, Necker Hospital, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff6">Université Paris Descartes, Institut Imagine, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff17">INSERM, Unité U768, Hôpital Necker Enfants-Malades, Paris, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cook, Matthew C" sort="Cook, Matthew C" uniqKey="Cook M" first="Matthew C." last="Cook">Matthew C. Cook</name>
<affiliation><nlm:aff wicri:cut=", and" id="aff18">Australian National University Medical School</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff19">John Curtin School of Medical Research, Australian National University, ACT, Canberra, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut="; and" id="aff20">Department of Immunology, The Canberra Hospital, Canberra, ACT, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name>
<affiliation><nlm:aff id="aff4">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U980, Necker Medical School, University Paris Descartes, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff6">Université Paris Descartes, Institut Imagine, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff7">Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Uzel, Gulbu" sort="Uzel, Gulbu" uniqKey="Uzel G" first="Gulbu" last="Uzel">Gulbu Uzel</name>
<affiliation><nlm:aff id="aff21">Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tangye, Stuart G" sort="Tangye, Stuart G" uniqKey="Tangye S" first="Stuart G." last="Tangye">Stuart G. Tangye</name>
<affiliation><nlm:aff id="aff1">Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">St Vincent’s Clinical School, University of New South Wales, Australia;</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Blood</title>
<idno type="ISSN">0006-4971</idno>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Key Points</title>
<p><list list-type="bullet"><list-item><p>IL21-mediated induction of CD25 expression on naïve human B cells requires STAT3.</p>
</list-item>
<list-item><p>A lack of response to IL-2 may amplify humoral immunodeficiency in patients with <italic>STAT3</italic>
, <italic>IL2RG</italic>
, or <italic>IL21R</italic>
mutations due to unresponsiveness to IL21.</p>
</list-item>
</list>
</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id>
<journal-id journal-id-type="iso-abbrev">Blood</journal-id>
<journal-id journal-id-type="hwp">bloodjournal</journal-id>
<journal-id journal-id-type="pmc">blood</journal-id>
<journal-id journal-id-type="publisher-id">Blood</journal-id>
<journal-title-group><journal-title>Blood</journal-title>
</journal-title-group>
<issn pub-type="ppub">0006-4971</issn>
<issn pub-type="epub">1528-0020</issn>
<publisher><publisher-name>American Society of Hematology</publisher-name>
<publisher-loc>Washington, DC</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24159173</article-id>
<article-id pub-id-type="pmc">3854113</article-id>
<article-id pub-id-type="publisher-id">2013/506865</article-id>
<article-id pub-id-type="doi">10.1182/blood-2013-06-506865</article-id>
<article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>12</subject>
</subj-group>
<subj-group subj-group-type="heading"><subject>Immunobiology</subject>
</subj-group>
</article-categories>
<title-group><article-title>IL-21 signalling via STAT3 primes human naïve B cells to respond to IL-2 to enhance their differentiation into plasmablasts</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Berglund</surname>
<given-names>Lucinda J.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Avery</surname>
<given-names>Danielle T.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ma</surname>
<given-names>Cindy S.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Moens</surname>
<given-names>Leen</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Deenick</surname>
<given-names>Elissa K.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bustamante</surname>
<given-names>Jacinta</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
<xref ref-type="aff" rid="aff5">5</xref>
<xref ref-type="aff" rid="aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Boisson-Dupuis</surname>
<given-names>Stephanie</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
<xref ref-type="aff" rid="aff7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wong</surname>
<given-names>Melanie</given-names>
</name>
<xref ref-type="aff" rid="aff8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Adelstein</surname>
<given-names>Stephen</given-names>
</name>
<xref ref-type="aff" rid="aff9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Arkwright</surname>
<given-names>Peter D.</given-names>
</name>
<xref ref-type="aff" rid="aff10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bacchetta</surname>
<given-names>Rosa</given-names>
</name>
<xref ref-type="aff" rid="aff11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bezrodnik</surname>
<given-names>Liliana</given-names>
</name>
<xref ref-type="aff" rid="aff12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dadi</surname>
<given-names>Harjit</given-names>
</name>
<xref ref-type="aff" rid="aff13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Roifman</surname>
<given-names>Chaim M.</given-names>
</name>
<xref ref-type="aff" rid="aff13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fulcher</surname>
<given-names>David A.</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ziegler</surname>
<given-names>John B.</given-names>
</name>
<xref ref-type="aff" rid="aff14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Smart</surname>
<given-names>Joanne M.</given-names>
</name>
<xref ref-type="aff" rid="aff15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kobayashi</surname>
<given-names>Masao</given-names>
</name>
<xref ref-type="aff" rid="aff16">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Picard</surname>
<given-names>Capucine</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
<xref ref-type="aff" rid="aff5">5</xref>
<xref ref-type="aff" rid="aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Durandy</surname>
<given-names>Anne</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
<xref ref-type="aff" rid="aff6">6</xref>
<xref ref-type="aff" rid="aff17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cook</surname>
<given-names>Matthew C.</given-names>
</name>
<xref ref-type="aff" rid="aff18">18</xref>
<xref ref-type="aff" rid="aff19">19</xref>
<xref ref-type="aff" rid="aff20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Casanova</surname>
<given-names>Jean-Laurent</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
<xref ref-type="aff" rid="aff6">6</xref>
<xref ref-type="aff" rid="aff7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Uzel</surname>
<given-names>Gulbu</given-names>
</name>
<xref ref-type="aff" rid="aff21">21</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Tangye</surname>
<given-names>Stuart G.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<aff id="aff1"><label>1</label>
Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia;</aff>
<aff id="aff2"><label>2</label>
St Vincent’s Clinical School, University of New South Wales, Australia;</aff>
<aff id="aff3"><label>3</label>
Department of Immunology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia;</aff>
<aff id="aff4"><label>4</label>
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U980, Necker Medical School, University Paris Descartes, Paris, France;</aff>
<aff id="aff5"><label>5</label>
Study Center for Primary Immunodeficiencies, AP-HP, Necker Hospital, Paris, France;</aff>
<aff id="aff6"><label>6</label>
Université Paris Descartes, Institut Imagine, Paris, France;</aff>
<aff id="aff7"><label>7</label>
Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY;</aff>
<aff id="aff8"><label>8</label>
Department of Immunology, Children’s Hospital at Westmead, Westmead, NSW, Australia;</aff>
<aff id="aff9"><label>9</label>
Clinical Immunology, Royal Prince Alfred Hospital, Sydney, NSW, Australia;</aff>
<aff id="aff10"><label>10</label>
University of Manchester, Royal Manchester Children’s Hospital, Manchester, United Kingdom;</aff>
<aff id="aff11"><label>11</label>
San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), San Raffaele Scientific Institute, Milan, Italy;</aff>
<aff id="aff12"><label>12</label>
Immunology Unit, Ricardo Gutiérrez Children Hosptial, Ciudad Autónoma de Buenos Aires, Argentina;</aff>
<aff id="aff13"><label>13</label>
Canadian Centre for Primary Immunodeficiency, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada;</aff>
<aff id="aff14"><label>14</label>
Department of Immunology, Sydney Children's Hospital, Randwick, NSW, Australia and School of Women’s and Children’s Health, University of NSW, Randwick, Australia;</aff>
<aff id="aff15"><label>15</label>
Department of Allergy and Immunology, Royal Children’s Hospital Melbourne, Melbourne, VIC, Australia;</aff>
<aff id="aff16"><label>16</label>
Department of Pediatrics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan;</aff>
<aff id="aff17"><label>17</label>
INSERM, Unité U768, Hôpital Necker Enfants-Malades, Paris, France;</aff>
<aff id="aff18"><label>18</label>
Australian National University Medical School, and</aff>
<aff id="aff19"><label>19</label>
John Curtin School of Medical Research, Australian National University, ACT, Canberra, Australia;</aff>
<aff id="aff20"><label>20</label>
Department of Immunology, The Canberra Hospital, Canberra, ACT, Australia; and</aff>
<aff id="aff21"><label>21</label>
Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD</aff>
</contrib-group>
<pub-date pub-type="ppub"><day>5</day>
<month>12</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epreprint"><day>24</day>
<month>10</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>5</day>
<month>12</month>
<year>2014</year>
</pub-date>
<volume>122</volume>
<issue>24</issue>
<fpage>3940</fpage>
<lpage>3950</lpage>
<history><date date-type="received"><day>03</day>
<month>6</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>10</day>
<month>10</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-year>2013</copyright-year>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="3940.pdf"></self-uri>
<abstract abstract-type="executive-summary"><title>Key Points</title>
<p><list list-type="bullet"><list-item><p>IL21-mediated induction of CD25 expression on naïve human B cells requires STAT3.</p>
</list-item>
<list-item><p>A lack of response to IL-2 may amplify humoral immunodeficiency in patients with <italic>STAT3</italic>
, <italic>IL2RG</italic>
, or <italic>IL21R</italic>
mutations due to unresponsiveness to IL21.</p>
</list-item>
</list>
</p>
</abstract>
<abstract><p>B-cell responses are guided by the integration of signals through the B-cell receptor (BCR), CD40, and cytokine receptors. The common γ chain (γc)-binding cytokine interleukin (IL)-21 drives humoral immune responses via STAT3-dependent induction of transcription factors required for plasma cell generation. We investigated additional mechanisms by which IL-21/STAT3 signaling modulates human B-cell responses by studying patients with <italic>STAT3</italic>
mutations. IL-21 strongly induced CD25 (IL-2Rα) in normal, but not STAT3-deficient, CD40L-stimulated naïve B cells. Chromatin immunoprecipitation confirmed <italic>IL2RA</italic>
as a direct target of STAT3. IL-21–induced CD25 expression was also impaired on B cells from patients with <italic>IL2RG</italic>
or <italic>IL21R</italic>
mutations, confirming a requirement for intact IL-21R signaling in this process. IL-2 increased plasmablast generation and immunoglobulin secretion from normal, but not CD25-deficient, naïve B cells stimulated with CD40L/IL-21. IL-2 and IL-21 were produced by T follicular helper cells, and neutralizing both cytokines abolished the B-cell helper capacity of these cells. Our results demonstrate that IL-21, via STAT3, sensitizes B cells to the stimulatory effects of IL-2. Thus, IL-2 may play an adjunctive role in IL-21–induced B-cell differentiation. Lack of this secondary effect of IL-21 may amplify the humoral immunodeficiency in patients with mutations in <italic>STAT3</italic>
, <italic>IL2RG</italic>
, or <italic>IL21R</italic>
due to impaired responsiveness to IL-21.</p>
</abstract>
<counts><page-count count="11"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
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