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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Better leukemia-free and overall survival in AML in first remission following cyclophosphamide in combination with busulfan compared with TBI</title><author><name sortKey="Copelan, Edward A" sort="Copelan, Edward A" uniqKey="Copelan E" first="Edward A." last="Copelan">Edward A. Copelan</name><affiliation><nlm:aff id="aff1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC;</nlm:aff></affiliation></author><author><name sortKey="Hamilton, Betty K" sort="Hamilton, Betty K" uniqKey="Hamilton B" first="Betty K." last="Hamilton">Betty K. Hamilton</name><affiliation><nlm:aff id="aff2">Cleveland Clinic Foundation, Cleveland, OH;</nlm:aff></affiliation></author><author><name sortKey="Avalos, Belinda" sort="Avalos, Belinda" uniqKey="Avalos B" first="Belinda" last="Avalos">Belinda Avalos</name><affiliation><nlm:aff id="aff1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC;</nlm:aff></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation><nlm:aff id="aff3">Center for International Blood and Marrow Transplant Research, Milwaukee, WI;</nlm:aff></affiliation></author><author><name sortKey="Bolwell, Brian J" sort="Bolwell, Brian J" uniqKey="Bolwell B" first="Brian J." last="Bolwell">Brian J. Bolwell</name><affiliation><nlm:aff id="aff2">Cleveland Clinic Foundation, Cleveland, OH;</nlm:aff></affiliation></author><author><name sortKey="Zhu, Xiaochun" sort="Zhu, Xiaochun" uniqKey="Zhu X" first="Xiaochun" last="Zhu">Xiaochun Zhu</name><affiliation><nlm:aff id="aff3">Center for International Blood and Marrow Transplant Research, Milwaukee, WI;</nlm:aff></affiliation></author><author><name sortKey="Aljurf, Mahmoud" sort="Aljurf, Mahmoud" uniqKey="Aljurf M" first="Mahmoud" last="Aljurf">Mahmoud Aljurf</name><affiliation><nlm:aff id="aff4">King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia;</nlm:aff></affiliation></author><author><name sortKey="Van Besien, Koen" sort="Van Besien, Koen" uniqKey="Van Besien K" first="Koen" last="Van Besien">Koen Van Besien</name><affiliation><nlm:aff id="aff5">Weill Cornell Medical College, New York, NY;</nlm:aff></affiliation></author><author><name sortKey="Bredeson, Christopher" sort="Bredeson, Christopher" uniqKey="Bredeson C" first="Christopher" last="Bredeson">Christopher Bredeson</name><affiliation><nlm:aff id="aff6">Division of Hematology, Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada;</nlm:aff></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation><nlm:aff id="aff7">Department of Hematology, University Hospital, Grenoble, France;</nlm:aff></affiliation></author><author><name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name><affiliation><nlm:aff id="aff8">Medical University of South Carolina, Charleston, SC;</nlm:aff></affiliation></author><author><name sortKey="De Lima, Marcos" sort="De Lima, Marcos" uniqKey="De Lima M" first="Marcos" last="De Lima">Marcos De Lima</name><affiliation><nlm:aff id="aff9">University Hospitals Case Medical Center, Cleveland, OH;</nlm:aff></affiliation></author><author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name><affiliation><nlm:aff id="aff10">Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Hale, Gregory A" sort="Hale, Gregory A" uniqKey="Hale G" first="Gregory A." last="Hale">Gregory A. Hale</name><affiliation><nlm:aff id="aff11">All Children’s Hospital, St. Petersburg, FL;</nlm:aff></affiliation></author><author><name sortKey="Halter, Joerg" sort="Halter, Joerg" uniqKey="Halter J" first="Joerg" last="Halter">Joerg Halter</name><affiliation><nlm:aff id="aff12">University Hospital Basel, Basel, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation><nlm:aff id="aff13">West Virginia University Hospitals, Morgantown, WV;</nlm:aff></affiliation></author><author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name><affiliation><nlm:aff id="aff14">Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Kamble, Rammurti T" sort="Kamble, Rammurti T" uniqKey="Kamble R" first="Rammurti T." last="Kamble">Rammurti T. Kamble</name><affiliation><nlm:aff id="aff15">Baylor College of Medicine Center for Cell and Gene Therapy, Houston, TX;</nlm:aff></affiliation></author><author><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R." last="Litzow">Mark R. Litzow</name><affiliation><nlm:aff id="aff16">Mayo Clinic Rochester, Rochester, MN;</nlm:aff></affiliation></author><author><name sortKey="Loren, Alison W" sort="Loren, Alison W" uniqKey="Loren A" first="Alison W." last="Loren">Alison W. Loren</name><affiliation><nlm:aff id="aff17">Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;</nlm:aff></affiliation></author><author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name><affiliation><nlm:aff id="aff18">Bristol Children’s Hospital, Bristol, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Olavarria, Eduardo" sort="Olavarria, Eduardo" uniqKey="Olavarria E" first="Eduardo" last="Olavarria">Eduardo Olavarria</name><affiliation><nlm:aff id="aff19">Catherine Lewis Center, Pamplona, Spain;</nlm:aff></affiliation></author><author><name sortKey="Roy, Vivek" sort="Roy, Vivek" uniqKey="Roy V" first="Vivek" last="Roy">Vivek Roy</name><affiliation><nlm:aff id="aff20">Mayo Clinic, Jacksonville, FL;</nlm:aff></affiliation></author><author><name sortKey="Sabloff, Mitchell" sort="Sabloff, Mitchell" uniqKey="Sabloff M" first="Mitchell" last="Sabloff">Mitchell Sabloff</name><affiliation><nlm:aff id="aff6">Division of Hematology, Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada;</nlm:aff></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><affiliation><nlm:aff id="aff21">Vanderbilt University Medical Center, Brentwood, TN;</nlm:aff></affiliation></author><author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name><affiliation><nlm:aff id="aff22">Cancer Care Manitoba/University of Manitoba, Winnipeg, Manitoba, Canada;</nlm:aff></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name><affiliation><nlm:aff id="aff23">Academische Ziekenhuis Maastricht, Maastricht, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name><affiliation><nlm:aff id="aff24">University of Minnesota Medical Center, Fairview, Minneapolis, MN;</nlm:aff></affiliation></author><author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name><affiliation><nlm:aff id="aff25">Emory University Hospital, Atlanta, GA;</nlm:aff></affiliation></author><author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name><affiliation><nlm:aff id="aff24">University of Minnesota Medical Center, Fairview, Minneapolis, MN;</nlm:aff></affiliation></author><author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name><affiliation><nlm:aff id="aff26">Shands HealthCare and University of Florida, Gainesville, FL;</nlm:aff></affiliation></author><author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name><affiliation><nlm:aff id="aff3">Center for International Blood and Marrow Transplant Research, Milwaukee, WI;</nlm:aff></affiliation></author><author><name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name><affiliation><nlm:aff id="aff24">University of Minnesota Medical Center, Fairview, Minneapolis, MN;</nlm:aff></affiliation></author><author><name sortKey="Szer, Jeff" sort="Szer, Jeff" uniqKey="Szer J" first="Jeff" last="Szer">Jeff Szer</name><affiliation><nlm:aff id="aff27">Royal Melbourne Hospital City Campus, Victoria, Australia;</nlm:aff></affiliation></author><author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name><affiliation><nlm:aff wicri:cut="; and" id="aff28">MD Anderson Cancer Center, Houston, TX</nlm:aff></affiliation></author><author><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name><affiliation><nlm:aff id="aff2">Cleveland Clinic Foundation, Cleveland, OH;</nlm:aff></affiliation></author><author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name><affiliation><nlm:aff id="aff29">Oregon Health and Science University, Portland, OR</nlm:aff></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation><nlm:aff id="aff3">Center for International Blood and Marrow Transplant Research, Milwaukee, WI;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24065243</idno><idno type="pmc">3854108</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854108</idno><idno type="RBID">PMC:3854108</idno><idno type="doi">10.1182/blood-2013-07-514448</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001800</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001800</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Better leukemia-free and overall survival in AML in first remission following cyclophosphamide in combination with busulfan compared with TBI</title><author><name sortKey="Copelan, Edward A" sort="Copelan, Edward A" uniqKey="Copelan E" first="Edward A." last="Copelan">Edward A. Copelan</name><affiliation><nlm:aff id="aff1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC;</nlm:aff></affiliation></author><author><name sortKey="Hamilton, Betty K" sort="Hamilton, Betty K" uniqKey="Hamilton B" first="Betty K." last="Hamilton">Betty K. Hamilton</name><affiliation><nlm:aff id="aff2">Cleveland Clinic Foundation, Cleveland, OH;</nlm:aff></affiliation></author><author><name sortKey="Avalos, Belinda" sort="Avalos, Belinda" uniqKey="Avalos B" first="Belinda" last="Avalos">Belinda Avalos</name><affiliation><nlm:aff id="aff1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC;</nlm:aff></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation><nlm:aff id="aff3">Center for International Blood and Marrow Transplant Research, Milwaukee, WI;</nlm:aff></affiliation></author><author><name sortKey="Bolwell, Brian J" sort="Bolwell, Brian J" uniqKey="Bolwell B" first="Brian J." last="Bolwell">Brian J. Bolwell</name><affiliation><nlm:aff id="aff2">Cleveland Clinic Foundation, Cleveland, OH;</nlm:aff></affiliation></author><author><name sortKey="Zhu, Xiaochun" sort="Zhu, Xiaochun" uniqKey="Zhu X" first="Xiaochun" last="Zhu">Xiaochun Zhu</name><affiliation><nlm:aff id="aff3">Center for International Blood and Marrow Transplant Research, Milwaukee, WI;</nlm:aff></affiliation></author><author><name sortKey="Aljurf, Mahmoud" sort="Aljurf, Mahmoud" uniqKey="Aljurf M" first="Mahmoud" last="Aljurf">Mahmoud Aljurf</name><affiliation><nlm:aff id="aff4">King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia;</nlm:aff></affiliation></author><author><name sortKey="Van Besien, Koen" sort="Van Besien, Koen" uniqKey="Van Besien K" first="Koen" last="Van Besien">Koen Van Besien</name><affiliation><nlm:aff id="aff5">Weill Cornell Medical College, New York, NY;</nlm:aff></affiliation></author><author><name sortKey="Bredeson, Christopher" sort="Bredeson, Christopher" uniqKey="Bredeson C" first="Christopher" last="Bredeson">Christopher Bredeson</name><affiliation><nlm:aff id="aff6">Division of Hematology, Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada;</nlm:aff></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation><nlm:aff id="aff7">Department of Hematology, University Hospital, Grenoble, France;</nlm:aff></affiliation></author><author><name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name><affiliation><nlm:aff id="aff8">Medical University of South Carolina, Charleston, SC;</nlm:aff></affiliation></author><author><name sortKey="De Lima, Marcos" sort="De Lima, Marcos" uniqKey="De Lima M" first="Marcos" last="De Lima">Marcos De Lima</name><affiliation><nlm:aff id="aff9">University Hospitals Case Medical Center, Cleveland, OH;</nlm:aff></affiliation></author><author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name><affiliation><nlm:aff id="aff10">Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Hale, Gregory A" sort="Hale, Gregory A" uniqKey="Hale G" first="Gregory A." last="Hale">Gregory A. Hale</name><affiliation><nlm:aff id="aff11">All Children’s Hospital, St. Petersburg, FL;</nlm:aff></affiliation></author><author><name sortKey="Halter, Joerg" sort="Halter, Joerg" uniqKey="Halter J" first="Joerg" last="Halter">Joerg Halter</name><affiliation><nlm:aff id="aff12">University Hospital Basel, Basel, Switzerland;</nlm:aff></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation><nlm:aff id="aff13">West Virginia University Hospitals, Morgantown, WV;</nlm:aff></affiliation></author><author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name><affiliation><nlm:aff id="aff14">Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Kamble, Rammurti T" sort="Kamble, Rammurti T" uniqKey="Kamble R" first="Rammurti T." last="Kamble">Rammurti T. Kamble</name><affiliation><nlm:aff id="aff15">Baylor College of Medicine Center for Cell and Gene Therapy, Houston, TX;</nlm:aff></affiliation></author><author><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R." last="Litzow">Mark R. Litzow</name><affiliation><nlm:aff id="aff16">Mayo Clinic Rochester, Rochester, MN;</nlm:aff></affiliation></author><author><name sortKey="Loren, Alison W" sort="Loren, Alison W" uniqKey="Loren A" first="Alison W." last="Loren">Alison W. Loren</name><affiliation><nlm:aff id="aff17">Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;</nlm:aff></affiliation></author><author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name><affiliation><nlm:aff id="aff18">Bristol Children’s Hospital, Bristol, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Olavarria, Eduardo" sort="Olavarria, Eduardo" uniqKey="Olavarria E" first="Eduardo" last="Olavarria">Eduardo Olavarria</name><affiliation><nlm:aff id="aff19">Catherine Lewis Center, Pamplona, Spain;</nlm:aff></affiliation></author><author><name sortKey="Roy, Vivek" sort="Roy, Vivek" uniqKey="Roy V" first="Vivek" last="Roy">Vivek Roy</name><affiliation><nlm:aff id="aff20">Mayo Clinic, Jacksonville, FL;</nlm:aff></affiliation></author><author><name sortKey="Sabloff, Mitchell" sort="Sabloff, Mitchell" uniqKey="Sabloff M" first="Mitchell" last="Sabloff">Mitchell Sabloff</name><affiliation><nlm:aff id="aff6">Division of Hematology, Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada;</nlm:aff></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><affiliation><nlm:aff id="aff21">Vanderbilt University Medical Center, Brentwood, TN;</nlm:aff></affiliation></author><author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name><affiliation><nlm:aff id="aff22">Cancer Care Manitoba/University of Manitoba, Winnipeg, Manitoba, Canada;</nlm:aff></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name><affiliation><nlm:aff id="aff23">Academische Ziekenhuis Maastricht, Maastricht, The Netherlands;</nlm:aff></affiliation></author><author><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name><affiliation><nlm:aff id="aff24">University of Minnesota Medical Center, Fairview, Minneapolis, MN;</nlm:aff></affiliation></author><author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name><affiliation><nlm:aff id="aff25">Emory University Hospital, Atlanta, GA;</nlm:aff></affiliation></author><author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name><affiliation><nlm:aff id="aff24">University of Minnesota Medical Center, Fairview, Minneapolis, MN;</nlm:aff></affiliation></author><author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name><affiliation><nlm:aff id="aff26">Shands HealthCare and University of Florida, Gainesville, FL;</nlm:aff></affiliation></author><author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name><affiliation><nlm:aff id="aff3">Center for International Blood and Marrow Transplant Research, Milwaukee, WI;</nlm:aff></affiliation></author><author><name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name><affiliation><nlm:aff id="aff24">University of Minnesota Medical Center, Fairview, Minneapolis, MN;</nlm:aff></affiliation></author><author><name sortKey="Szer, Jeff" sort="Szer, Jeff" uniqKey="Szer J" first="Jeff" last="Szer">Jeff Szer</name><affiliation><nlm:aff id="aff27">Royal Melbourne Hospital City Campus, Victoria, Australia;</nlm:aff></affiliation></author><author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name><affiliation><nlm:aff wicri:cut="; and" id="aff28">MD Anderson Cancer Center, Houston, TX</nlm:aff></affiliation></author><author><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name><affiliation><nlm:aff id="aff2">Cleveland Clinic Foundation, Cleveland, OH;</nlm:aff></affiliation></author><author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name><affiliation><nlm:aff id="aff29">Oregon Health and Science University, Portland, OR</nlm:aff></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation><nlm:aff id="aff3">Center for International Blood and Marrow Transplant Research, Milwaukee, WI;</nlm:aff></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Key Points</title><p><list list-type="bullet"><list-item><p>In combination with cyclophosphamide, intravenous busulfan is associated with better leukemia-free and overall survival in AML than TBI.</p></list-item></list></p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id><journal-id journal-id-type="iso-abbrev">Blood</journal-id><journal-id journal-id-type="hwp">bloodjournal</journal-id><journal-id journal-id-type="pmc">blood</journal-id><journal-id journal-id-type="publisher-id">Blood</journal-id><journal-title-group><journal-title>Blood</journal-title></journal-title-group><issn pub-type="ppub">0006-4971</issn><issn pub-type="epub">1528-0020</issn><publisher><publisher-name>American Society of Hematology</publisher-name><publisher-loc>Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24065243</article-id><article-id pub-id-type="pmc">3854108</article-id><article-id pub-id-type="publisher-id">2013/514448</article-id><article-id pub-id-type="doi">10.1182/blood-2013-07-514448</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>2</subject><subject>29</subject><subject>33</subject><subject>17</subject></subj-group><subj-group subj-group-type="heading"><subject>Plenary Paper</subject></subj-group></article-categories><title-group><article-title>Better leukemia-free and overall survival in AML in first remission following cyclophosphamide in combination with busulfan compared with TBI</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Copelan</surname><given-names>Edward A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hamilton</surname><given-names>Betty K.</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Avalos</surname><given-names>Belinda</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ahn</surname><given-names>Kwang Woo</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Bolwell</surname><given-names>Brian J.</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhu</surname><given-names>Xiaochun</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Aljurf</surname><given-names>Mahmoud</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>van Besien</surname><given-names>Koen</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Bredeson</surname><given-names>Christopher</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Cahn</surname><given-names>Jean-Yves</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Costa</surname><given-names>Luciano J.</given-names></name><xref ref-type="aff" rid="aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>de Lima</surname><given-names>Marcos</given-names></name><xref ref-type="aff" rid="aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Gale</surname><given-names>Robert Peter</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Hale</surname><given-names>Gregory A.</given-names></name><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Halter</surname><given-names>Joerg</given-names></name><xref ref-type="aff" rid="aff12">12</xref></contrib><contrib 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contrib-type="author"><name><surname>Ustun</surname><given-names>Celalettin</given-names></name><xref ref-type="aff" rid="aff24">24</xref></contrib><contrib contrib-type="author"><name><surname>Waller</surname><given-names>Edmund K.</given-names></name><xref ref-type="aff" rid="aff25">25</xref></contrib><contrib contrib-type="author"><name><surname>Weisdorf</surname><given-names>Daniel J.</given-names></name><xref ref-type="aff" rid="aff24">24</xref></contrib><contrib contrib-type="author"><name><surname>Wirk</surname><given-names>Baldeep</given-names></name><xref ref-type="aff" rid="aff26">26</xref></contrib><contrib contrib-type="author"><name><surname>Horowitz</surname><given-names>Mary M.</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Arora</surname><given-names>Mukta</given-names></name><xref ref-type="aff" rid="aff24">24</xref></contrib><contrib contrib-type="author"><name><surname>Szer</surname><given-names>Jeff</given-names></name><xref ref-type="aff" rid="aff27">27</xref></contrib><contrib contrib-type="author"><name><surname>Cortes</surname><given-names>Jorge</given-names></name><xref ref-type="aff" rid="aff28">28</xref></contrib><contrib contrib-type="author"><name><surname>Kalaycio</surname><given-names>Matt E.</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Maziarz</surname><given-names>Richard T.</given-names></name><xref ref-type="aff" rid="aff29">29</xref></contrib><contrib contrib-type="author"><name><surname>Saber</surname><given-names>Wael</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><aff id="aff1"><label>1</label>Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC;</aff><aff id="aff2"><label>2</label>Cleveland Clinic Foundation, Cleveland, OH;</aff><aff id="aff3"><label>3</label>Center for International Blood and Marrow Transplant Research, Milwaukee, WI;</aff><aff id="aff4"><label>4</label>King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia;</aff><aff id="aff5"><label>5</label>Weill Cornell Medical College, New York, NY;</aff><aff id="aff6"><label>6</label>Division of Hematology, Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada;</aff><aff id="aff7"><label>7</label>Department of Hematology, University Hospital, Grenoble, France;</aff><aff id="aff8"><label>8</label>Medical University of South Carolina, Charleston, SC;</aff><aff id="aff9"><label>9</label>University Hospitals Case Medical Center, Cleveland, OH;</aff><aff id="aff10"><label>10</label>Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London, United Kingdom;</aff><aff id="aff11"><label>11</label>All Children’s Hospital, St. Petersburg, FL;</aff><aff id="aff12"><label>12</label>University Hospital Basel, Basel, Switzerland;</aff><aff id="aff13"><label>13</label>West Virginia University Hospitals, Morgantown, WV;</aff><aff id="aff14"><label>14</label>Fred Hutchinson Cancer Research Center, Seattle, WA;</aff><aff id="aff15"><label>15</label>Baylor College of Medicine Center for Cell and Gene Therapy, Houston, TX;</aff><aff id="aff16"><label>16</label>Mayo Clinic Rochester, Rochester, MN;</aff><aff id="aff17"><label>17</label>Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;</aff><aff id="aff18"><label>18</label>Bristol Children’s Hospital, Bristol, United Kingdom;</aff><aff id="aff19"><label>19</label>Catherine Lewis Center, Pamplona, Spain;</aff><aff id="aff20"><label>20</label>Mayo Clinic, Jacksonville, FL;</aff><aff id="aff21"><label>21</label>Vanderbilt University Medical Center, Brentwood, TN;</aff><aff id="aff22"><label>22</label>Cancer Care Manitoba/University of Manitoba, Winnipeg, Manitoba, Canada;</aff><aff id="aff23"><label>23</label>Academische Ziekenhuis Maastricht, Maastricht, The Netherlands;</aff><aff id="aff24"><label>24</label>University of Minnesota Medical Center, Fairview, Minneapolis, MN;</aff><aff id="aff25"><label>25</label>Emory University Hospital, Atlanta, GA;</aff><aff id="aff26"><label>26</label>Shands HealthCare and University of Florida, Gainesville, FL;</aff><aff id="aff27"><label>27</label>Royal Melbourne Hospital City Campus, Victoria, Australia;</aff><aff id="aff28"><label>28</label>MD Anderson Cancer Center, Houston, TX; and</aff><aff id="aff29"><label>29</label>Oregon Health and Science University, Portland, OR</aff></contrib-group><pub-date pub-type="ppub"><day>5</day><month>12</month><year>2013</year></pub-date><pub-date pub-type="epreprint"><day>24</day><month>9</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>5</day><month>12</month><year>2014</year></pub-date><volume>122</volume><issue>24</issue><fpage>3863</fpage><lpage>3870</lpage><history><date date-type="received"><day>18</day><month>7</month><year>2013</year></date><date date-type="accepted"><day>17</day><month>9</month><year>2013</year></date></history><permissions><copyright-statement>© 2013 by The American Society of Hematology</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="3863.pdf"></self-uri><related-article related-article-type="article-reference" id="d35e515" vol="122" page="3856" issue="24" ext-link-type="pmc"></related-article><related-article related-article-type="article-reference" id="d35e516" vol="122" page="3871" issue="24" ext-link-type="pmc"></related-article><abstract abstract-type="executive-summary"><title>Key Points</title><p><list list-type="bullet"><list-item><p>In combination with cyclophosphamide, intravenous busulfan is associated with better leukemia-free and overall survival in AML than TBI.</p></list-item></list></p></abstract><abstract><p>Cyclophosphamide combined with total body irradiation (Cy/TBI) or busulfan (BuCy) are the most widely used myeloablative conditioning regimens for allotransplants. Recent data regarding their comparative effectiveness are lacking. We analyzed data from the Center for International Blood and Marrow Transplant Research for 1230 subjects receiving a first hematopoietic cell transplant from a human leukocyte antigen-matched sibling or from an unrelated donor during the years 2000 to 2006 for acute myeloid leukemia (AML) in first complete remission (CR) after conditioning with Cy/TBI or oral or intravenous (IV) BuCy. Multivariate analysis showed significantly less nonrelapse mortality (relative risk [RR] = 0.58; 95% confidence interval [CI]: 0.39-0.86; <italic>P</italic> = .007), and relapse after, but not before, 1 year posttransplant (RR = 0.23; 95% CI: 0.08-0.65; <italic>P</italic> = .006), and better leukemia-free survival (RR = 0.70; 95% CI: 0.55-0.88; <italic>P</italic> = .003) and survival (RR = 0.68; 95% CI: 0.52-0.88; <italic>P</italic> = .003) in persons receiving IV, but not oral, Bu compared with TBI. In combination with Cy, IV Bu is associated with superior outcomes compared with TBI in patients with AML in first CR.</p></abstract><funding-group><award-group><funding-source id="CS100">National Institutes of Health</funding-source></award-group></funding-group><counts><page-count count="8"></page-count></counts><custom-meta-group><custom-meta><meta-name>access</meta-name><meta-value>free</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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