Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Analysis of risk factors influencing outcomes after cord blood transplantation in children with juvenile myelomonocytic leukemia: a EUROCORD, EBMT, EWOG-MDS, CIBMTR study</title><author><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name><affiliation><nlm:aff id="aff1">Department of Pediatric Hematology and Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Bambino Gesù, Università di Pavia, Rome, Italy;</nlm:aff></affiliation></author><author><name sortKey="Crotta, Alessandro" sort="Crotta, Alessandro" uniqKey="Crotta A" first="Alessandro" last="Crotta">Alessandro Crotta</name><affiliation><nlm:aff id="aff2">Eurocord, Hôpital Saint Louis Assistance Publique-Hôpitaux de Paris, University Paris VII, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Ruggeri, Annalisa" sort="Ruggeri, Annalisa" uniqKey="Ruggeri A" first="Annalisa" last="Ruggeri">Annalisa Ruggeri</name><affiliation><nlm:aff id="aff2">Eurocord, Hôpital Saint Louis Assistance Publique-Hôpitaux de Paris, University Paris VII, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Rome Transplant Network, University Tor Vergata, Rome, Italy;</nlm:aff></affiliation></author><author><name sortKey="Eapen, Mary" sort="Eapen, Mary" uniqKey="Eapen M" first="Mary" last="Eapen">Mary Eapen</name><affiliation><nlm:aff id="aff4">Center for International Blood and Marrow Transplant Research, Milwaukee, WI;</nlm:aff></affiliation></author><author><name sortKey="Wagner, John E" sort="Wagner, John E" uniqKey="Wagner J" first="John E." last="Wagner">John E. Wagner</name><affiliation><nlm:aff id="aff5">Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN;</nlm:aff></affiliation></author><author><name sortKey="Macmillan, Margaret L" sort="Macmillan, Margaret L" uniqKey="Macmillan M" first="Margaret L." last="Macmillan">Margaret L. Macmillan</name><affiliation><nlm:aff id="aff5">Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN;</nlm:aff></affiliation></author><author><name sortKey="Zecca, Marco" sort="Zecca, Marco" uniqKey="Zecca M" first="Marco" last="Zecca">Marco Zecca</name><affiliation><nlm:aff id="aff6">Pediatric Hematology-Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;</nlm:aff></affiliation></author><author><name sortKey="Kurtzberg, Joanne" sort="Kurtzberg, Joanne" uniqKey="Kurtzberg J" first="Joanne" last="Kurtzberg">Joanne Kurtzberg</name><affiliation><nlm:aff id="aff7">Division of Blood and Marrow Transplantation, Department of Pediatrics, Duke University Medical Center, Durham, NC;</nlm:aff></affiliation></author><author><name sortKey="Bonfim, Carmem" sort="Bonfim, Carmem" uniqKey="Bonfim C" first="Carmem" last="Bonfim">Carmem Bonfim</name><affiliation><nlm:aff id="aff8">Bone Marrow Transplant, Federal University of Parana, Curitiba, Brasil;</nlm:aff></affiliation></author><author><name sortKey="Vora, Ajay" sort="Vora, Ajay" uniqKey="Vora A" first="Ajay" last="Vora">Ajay Vora</name><affiliation><nlm:aff id="aff9">Department of Haematology, Sheffield Children’s Hospital, Sheffield, UK;</nlm:aff></affiliation></author><author><name sortKey="Diaz De Heredia, Cristina" sort="Diaz De Heredia, Cristina" uniqKey="Diaz De Heredia C" first="Cristina" last="Díaz De Heredia">Cristina Díaz De Heredia</name><affiliation><nlm:aff id="aff10">Hospital Vall d’Hebron, Barcelona, Spain;</nlm:aff></affiliation></author><author><name sortKey="Teague, Lochie" sort="Teague, Lochie" uniqKey="Teague L" first="Lochie" last="Teague">Lochie Teague</name><affiliation><nlm:aff id="aff11">Starship Hospital, Auckland, New Zealand;</nlm:aff></affiliation></author><author><name sortKey="Stein, Jerry" sort="Stein, Jerry" uniqKey="Stein J" first="Jerry" last="Stein">Jerry Stein</name><affiliation><nlm:aff id="aff12">Department of Pediatric Hematology Oncology and BMT Unit, Schneider Children’s Medical Center of Israel, Petah-Tikva, Israel;</nlm:aff></affiliation></author><author><name sortKey="O Rien, Tracey A" sort="O Rien, Tracey A" uniqKey="O Rien T" first="Tracey A." last="O Rien">Tracey A. O Rien</name><affiliation><nlm:aff id="aff13">Cord & Marrow Transplant Program, Centre for Children’s Cancer & Blood Disorders, Sydney Children's Hospital, Sydney, Australia;</nlm:aff></affiliation></author><author><name sortKey="Bittencourt, Henrique" sort="Bittencourt, Henrique" uniqKey="Bittencourt H" first="Henrique" last="Bittencourt">Henrique Bittencourt</name><affiliation><nlm:aff id="aff14">Centre Hospitalier Universitaire Sainte-Justine, Montreal, Canada;</nlm:aff></affiliation></author><author><name sortKey="Madureira, Adrienne" sort="Madureira, Adrienne" uniqKey="Madureira A" first="Adrienne" last="Madureira">Adrienne Madureira</name><affiliation><nlm:aff id="aff15">Instituto Nacional de Cancer, Rio de Janeiro, Brasil;</nlm:aff></affiliation></author><author><name sortKey="Strahm, Brigitte" sort="Strahm, Brigitte" uniqKey="Strahm B" first="Brigitte" last="Strahm">Brigitte Strahm</name><affiliation><nlm:aff wicri:cut="; and" id="aff16">Division of Pediatric Hematology and Oncology, University Children's Hospital Freiburg, Freiburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Peters, Christina" sort="Peters, Christina" uniqKey="Peters C" first="Christina" last="Peters">Christina Peters</name><affiliation><nlm:aff id="aff17">Paediatric Diseases Working Party-European Group for Blood and Marrow Transplantation, St-Anna Kinderspital, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Niemeyer, Charlotte" sort="Niemeyer, Charlotte" uniqKey="Niemeyer C" first="Charlotte" last="Niemeyer">Charlotte Niemeyer</name><affiliation><nlm:aff wicri:cut="; and" id="aff16">Division of Pediatric Hematology and Oncology, University Children's Hospital Freiburg, Freiburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name><affiliation><nlm:aff id="aff2">Eurocord, Hôpital Saint Louis Assistance Publique-Hôpitaux de Paris, University Paris VII, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Rocha, Vanderson" sort="Rocha, Vanderson" uniqKey="Rocha V" first="Vanderson" last="Rocha">Vanderson Rocha</name><affiliation><nlm:aff id="aff2">Eurocord, Hôpital Saint Louis Assistance Publique-Hôpitaux de Paris, University Paris VII, Paris, France;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23926304</idno><idno type="pmc">3836039</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836039</idno><idno type="RBID">PMC:3836039</idno><idno type="doi">10.1182/blood-2013-03-491589</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001799</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001799</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Analysis of risk factors influencing outcomes after cord blood transplantation in children with juvenile myelomonocytic leukemia: a EUROCORD, EBMT, EWOG-MDS, CIBMTR study</title><author><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name><affiliation><nlm:aff id="aff1">Department of Pediatric Hematology and Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Bambino Gesù, Università di Pavia, Rome, Italy;</nlm:aff></affiliation></author><author><name sortKey="Crotta, Alessandro" sort="Crotta, Alessandro" uniqKey="Crotta A" first="Alessandro" last="Crotta">Alessandro Crotta</name><affiliation><nlm:aff id="aff2">Eurocord, Hôpital Saint Louis Assistance Publique-Hôpitaux de Paris, University Paris VII, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Ruggeri, Annalisa" sort="Ruggeri, Annalisa" uniqKey="Ruggeri A" first="Annalisa" last="Ruggeri">Annalisa Ruggeri</name><affiliation><nlm:aff id="aff2">Eurocord, Hôpital Saint Louis Assistance Publique-Hôpitaux de Paris, University Paris VII, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Rome Transplant Network, University Tor Vergata, Rome, Italy;</nlm:aff></affiliation></author><author><name sortKey="Eapen, Mary" sort="Eapen, Mary" uniqKey="Eapen M" first="Mary" last="Eapen">Mary Eapen</name><affiliation><nlm:aff id="aff4">Center for International Blood and Marrow Transplant Research, Milwaukee, WI;</nlm:aff></affiliation></author><author><name sortKey="Wagner, John E" sort="Wagner, John E" uniqKey="Wagner J" first="John E." last="Wagner">John E. Wagner</name><affiliation><nlm:aff id="aff5">Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN;</nlm:aff></affiliation></author><author><name sortKey="Macmillan, Margaret L" sort="Macmillan, Margaret L" uniqKey="Macmillan M" first="Margaret L." last="Macmillan">Margaret L. Macmillan</name><affiliation><nlm:aff id="aff5">Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN;</nlm:aff></affiliation></author><author><name sortKey="Zecca, Marco" sort="Zecca, Marco" uniqKey="Zecca M" first="Marco" last="Zecca">Marco Zecca</name><affiliation><nlm:aff id="aff6">Pediatric Hematology-Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;</nlm:aff></affiliation></author><author><name sortKey="Kurtzberg, Joanne" sort="Kurtzberg, Joanne" uniqKey="Kurtzberg J" first="Joanne" last="Kurtzberg">Joanne Kurtzberg</name><affiliation><nlm:aff id="aff7">Division of Blood and Marrow Transplantation, Department of Pediatrics, Duke University Medical Center, Durham, NC;</nlm:aff></affiliation></author><author><name sortKey="Bonfim, Carmem" sort="Bonfim, Carmem" uniqKey="Bonfim C" first="Carmem" last="Bonfim">Carmem Bonfim</name><affiliation><nlm:aff id="aff8">Bone Marrow Transplant, Federal University of Parana, Curitiba, Brasil;</nlm:aff></affiliation></author><author><name sortKey="Vora, Ajay" sort="Vora, Ajay" uniqKey="Vora A" first="Ajay" last="Vora">Ajay Vora</name><affiliation><nlm:aff id="aff9">Department of Haematology, Sheffield Children’s Hospital, Sheffield, UK;</nlm:aff></affiliation></author><author><name sortKey="Diaz De Heredia, Cristina" sort="Diaz De Heredia, Cristina" uniqKey="Diaz De Heredia C" first="Cristina" last="Díaz De Heredia">Cristina Díaz De Heredia</name><affiliation><nlm:aff id="aff10">Hospital Vall d’Hebron, Barcelona, Spain;</nlm:aff></affiliation></author><author><name sortKey="Teague, Lochie" sort="Teague, Lochie" uniqKey="Teague L" first="Lochie" last="Teague">Lochie Teague</name><affiliation><nlm:aff id="aff11">Starship Hospital, Auckland, New Zealand;</nlm:aff></affiliation></author><author><name sortKey="Stein, Jerry" sort="Stein, Jerry" uniqKey="Stein J" first="Jerry" last="Stein">Jerry Stein</name><affiliation><nlm:aff id="aff12">Department of Pediatric Hematology Oncology and BMT Unit, Schneider Children’s Medical Center of Israel, Petah-Tikva, Israel;</nlm:aff></affiliation></author><author><name sortKey="O Rien, Tracey A" sort="O Rien, Tracey A" uniqKey="O Rien T" first="Tracey A." last="O Rien">Tracey A. O Rien</name><affiliation><nlm:aff id="aff13">Cord & Marrow Transplant Program, Centre for Children’s Cancer & Blood Disorders, Sydney Children's Hospital, Sydney, Australia;</nlm:aff></affiliation></author><author><name sortKey="Bittencourt, Henrique" sort="Bittencourt, Henrique" uniqKey="Bittencourt H" first="Henrique" last="Bittencourt">Henrique Bittencourt</name><affiliation><nlm:aff id="aff14">Centre Hospitalier Universitaire Sainte-Justine, Montreal, Canada;</nlm:aff></affiliation></author><author><name sortKey="Madureira, Adrienne" sort="Madureira, Adrienne" uniqKey="Madureira A" first="Adrienne" last="Madureira">Adrienne Madureira</name><affiliation><nlm:aff id="aff15">Instituto Nacional de Cancer, Rio de Janeiro, Brasil;</nlm:aff></affiliation></author><author><name sortKey="Strahm, Brigitte" sort="Strahm, Brigitte" uniqKey="Strahm B" first="Brigitte" last="Strahm">Brigitte Strahm</name><affiliation><nlm:aff wicri:cut="; and" id="aff16">Division of Pediatric Hematology and Oncology, University Children's Hospital Freiburg, Freiburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Peters, Christina" sort="Peters, Christina" uniqKey="Peters C" first="Christina" last="Peters">Christina Peters</name><affiliation><nlm:aff id="aff17">Paediatric Diseases Working Party-European Group for Blood and Marrow Transplantation, St-Anna Kinderspital, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Niemeyer, Charlotte" sort="Niemeyer, Charlotte" uniqKey="Niemeyer C" first="Charlotte" last="Niemeyer">Charlotte Niemeyer</name><affiliation><nlm:aff wicri:cut="; and" id="aff16">Division of Pediatric Hematology and Oncology, University Children's Hospital Freiburg, Freiburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name><affiliation><nlm:aff id="aff2">Eurocord, Hôpital Saint Louis Assistance Publique-Hôpitaux de Paris, University Paris VII, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Rocha, Vanderson" sort="Rocha, Vanderson" uniqKey="Rocha V" first="Vanderson" last="Rocha">Vanderson Rocha</name><affiliation><nlm:aff id="aff2">Eurocord, Hôpital Saint Louis Assistance Publique-Hôpitaux de Paris, University Paris VII, Paris, France;</nlm:aff></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Key Points</title><p><list list-type="bullet"><list-item><p>UCBT is a suitable option for children with JMML, being able to cure a relevant proportion of patients.</p></list-item><list-item><p>Because disease recurrence remains the major cause of treatment failure after UCBT, strategies aimed at reducing relapse are desirable.</p></list-item></list></p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id><journal-id journal-id-type="iso-abbrev">Blood</journal-id><journal-id journal-id-type="hwp">bloodjournal</journal-id><journal-id journal-id-type="pmc">blood</journal-id><journal-id journal-id-type="publisher-id">Blood</journal-id><journal-title-group><journal-title>Blood</journal-title></journal-title-group><issn pub-type="ppub">0006-4971</issn><issn pub-type="epub">1528-0020</issn><publisher><publisher-name>American Society of Hematology</publisher-name><publisher-loc>Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23926304</article-id><article-id pub-id-type="pmc">3836039</article-id><article-id pub-id-type="publisher-id">2013/491589</article-id><article-id pub-id-type="doi">10.1182/blood-2013-03-491589</article-id><article-categories><subj-group subj-group-type="heading"><subject>Transplantation</subject></subj-group></article-categories><title-group><article-title>Analysis of risk factors influencing outcomes after cord blood transplantation in children with juvenile myelomonocytic leukemia: a EUROCORD, EBMT, EWOG-MDS, CIBMTR study</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Locatelli</surname><given-names>Franco</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Crotta</surname><given-names>Alessandro</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ruggeri</surname><given-names>Annalisa</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Eapen</surname><given-names>Mary</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Wagner</surname><given-names>John E.</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>MacMillan</surname><given-names>Margaret L.</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Zecca</surname><given-names>Marco</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Kurtzberg</surname><given-names>Joanne</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Bonfim</surname><given-names>Carmem</given-names></name><xref ref-type="aff" rid="aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>Vora</surname><given-names>Ajay</given-names></name><xref ref-type="aff" rid="aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Díaz de Heredia</surname><given-names>Cristina</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Teague</surname><given-names>Lochie</given-names></name><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Stein</surname><given-names>Jerry</given-names></name><xref ref-type="aff" rid="aff12">12</xref></contrib><contrib contrib-type="author"><name><surname>O’Brien</surname><given-names>Tracey A.</given-names></name><xref ref-type="aff" rid="aff13">13</xref></contrib><contrib contrib-type="author"><name><surname>Bittencourt</surname><given-names>Henrique</given-names></name><xref ref-type="aff" rid="aff14">14</xref></contrib><contrib contrib-type="author"><name><surname>Madureira</surname><given-names>Adrienne</given-names></name><xref ref-type="aff" rid="aff15">15</xref></contrib><contrib contrib-type="author"><name><surname>Strahm</surname><given-names>Brigitte</given-names></name><xref ref-type="aff" rid="aff16">16</xref></contrib><contrib contrib-type="author"><name><surname>Peters</surname><given-names>Christina</given-names></name><xref ref-type="aff" rid="aff17">17</xref></contrib><contrib contrib-type="author"><name><surname>Niemeyer</surname><given-names>Charlotte</given-names></name><xref ref-type="aff" rid="aff16">16</xref></contrib><contrib contrib-type="author"><name><surname>Gluckman</surname><given-names>Eliane</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Rocha</surname><given-names>Vanderson</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><aff id="aff1"><label>1</label>Department of Pediatric Hematology and Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Bambino Gesù, Università di Pavia, Rome, Italy;</aff><aff id="aff2"><label>2</label>Eurocord, Hôpital Saint Louis Assistance Publique-Hôpitaux de Paris, University Paris VII, Paris, France;</aff><aff id="aff3"><label>3</label>Rome Transplant Network, University Tor Vergata, Rome, Italy;</aff><aff id="aff4"><label>4</label>Center for International Blood and Marrow Transplant Research, Milwaukee, WI;</aff><aff id="aff5"><label>5</label>Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN;</aff><aff id="aff6"><label>6</label>Pediatric Hematology-Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;</aff><aff id="aff7"><label>7</label>Division of Blood and Marrow Transplantation, Department of Pediatrics, Duke University Medical Center, Durham, NC;</aff><aff id="aff8"><label>8</label>Bone Marrow Transplant, Federal University of Parana, Curitiba, Brasil;</aff><aff id="aff9"><label>9</label>Department of Haematology, Sheffield Children’s Hospital, Sheffield, UK;</aff><aff id="aff10"><label>10</label>Hospital Vall d’Hebron, Barcelona, Spain;</aff><aff id="aff11"><label>11</label>Starship Hospital, Auckland, New Zealand;</aff><aff id="aff12"><label>12</label>Department of Pediatric Hematology Oncology and BMT Unit, Schneider Children’s Medical Center of Israel, Petah-Tikva, Israel;</aff><aff id="aff13"><label>13</label>Cord & Marrow Transplant Program, Centre for Children’s Cancer & Blood Disorders, Sydney Children's Hospital, Sydney, Australia;</aff><aff id="aff14"><label>14</label>Centre Hospitalier Universitaire Sainte-Justine, Montreal, Canada;</aff><aff id="aff15"><label>15</label>Instituto Nacional de Cancer, Rio de Janeiro, Brasil;</aff><aff id="aff16"><label>16</label>Division of Pediatric Hematology and Oncology, University Children's Hospital Freiburg, Freiburg, Germany; and</aff><aff id="aff17"><label>17</label>Paediatric Diseases Working Party-European Group for Blood and Marrow Transplantation, St-Anna Kinderspital, Vienna, Austria</aff></contrib-group><pub-date pub-type="ppub"><day>19</day><month>9</month><year>2013</year></pub-date><pub-date pub-type="epreprint"><day>07</day><month>8</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>19</day><month>9</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>122</volume><issue>12</issue><fpage>2135</fpage><lpage>2141</lpage><history><date date-type="received"><day>18</day><month>3</month><year>2013</year></date><date date-type="accepted"><day>25</day><month>7</month><year>2013</year></date></history><permissions><copyright-statement>© 2013 by The American Society of Hematology</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="2135.pdf"></self-uri><abstract abstract-type="executive-summary"><title>Key Points</title><p><list list-type="bullet"><list-item><p>UCBT is a suitable option for children with JMML, being able to cure a relevant proportion of patients.</p></list-item><list-item><p>Because disease recurrence remains the major cause of treatment failure after UCBT, strategies aimed at reducing relapse are desirable.</p></list-item></list></p></abstract><abstract><p>We retrospectively analyzed 110 patients with juvenile myelomonocytic leukemia, given single-unit, unrelated donor umbilical cord blood transplantation. Median age at diagnosis and at transplantation was 1.4 years (age range, 0.1-6.4 years) and 2.2 years (age range, 0.5-7.4 years), respectively. Before transplantation, 88 patients received chemotherapy; splenectomy was performed in 24 patients. Monosomy of chromosome 7 was the most frequent cytogenetic abnormality, found in 24% of patients. All but 8 patients received myeloablative conditioning; cyclosporine plus steroids was the most common graft-versus-host disease prophylaxis. Sixteen percent of units were HLA-matched with the recipient, whereas 43% and 35% had either 1 or 2 to 3 HLA disparities, respectively. The median number of nucleated cells infused was 7.1 × 10<sup>7</sup>/kg (range, 1.7-27.6 × 10<sup>7</sup>/kg). With a median follow-up of 64 months (range, 14-174 months), the 5-year cumulative incidences of transplantation-related mortality and relapse were 22% and 33%, respectively. The 5-year disease-free survival rate was 44%. In multivariate analysis, factors predicting better disease-free survival were age younger than 1.4 years at diagnosis (hazard ratio [HR], 0.42; <italic>P</italic> = .005), 0 to 1 HLA disparities in the donor/recipient pair (HR, 0.4; <italic>P</italic> = .009), and karyotype other than monosomy 7 (HR, 0.5; <italic>P</italic> = .02). Umbilical cord blood transplantation may cure a relevant proportion of children with juvenile myelomonocytic leukemia. Because disease recurrence remains the major cause of treatment failure, strategies to reduce incidence of relapse are warranted.</p></abstract><counts><page-count count="7"></page-count></counts><custom-meta-group><custom-meta><meta-name>access</meta-name><meta-value>free</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 0017990 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 0017990 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |