Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Regulation of memory B-cell survival by the BH3-only protein Puma</title><author><name sortKey="Clybouw, Cyril" sort="Clybouw, Cyril" uniqKey="Clybouw C" first="Cyril" last="Clybouw">Cyril Clybouw</name><affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Fischer, Silke" sort="Fischer, Silke" uniqKey="Fischer S" first="Silke" last="Fischer">Silke Fischer</name><affiliation><nlm:aff id="aff3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Auffredou, Marie Therese" sort="Auffredou, Marie Therese" uniqKey="Auffredou M" first="Marie Thérèse" last="Auffredou">Marie Thérèse Auffredou</name><affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Hugues, Patricia" sort="Hugues, Patricia" uniqKey="Hugues P" first="Patricia" last="Hugues">Patricia Hugues</name><affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Inserm UMR-S 802 and Assistance Publique–Hôpitanx de Paris Hopital Bicêtre, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Alexia, Catherine" sort="Alexia, Catherine" uniqKey="Alexia C" first="Catherine" last="Alexia">Catherine Alexia</name><affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Bouillet, Philippe" sort="Bouillet, Philippe" uniqKey="Bouillet P" first="Philippe" last="Bouillet">Philippe Bouillet</name><affiliation><nlm:aff id="aff3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Raphael, Martine" sort="Raphael, Martine" uniqKey="Raphael M" first="Martine" last="Raphael">Martine Raphael</name><affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Inserm UMR-S 802 and Assistance Publique–Hôpitanx de Paris Hopital Bicêtre, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Leca, Gerald" sort="Leca, Gerald" uniqKey="Leca G" first="Gérald" last="Leca">Gérald Leca</name><affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Strasser, Andreas" sort="Strasser, Andreas" uniqKey="Strasser A" first="Andreas" last="Strasser">Andreas Strasser</name><affiliation><nlm:aff id="aff3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Tarlinton, David M" sort="Tarlinton, David M" uniqKey="Tarlinton D" first="David M." last="Tarlinton">David M. Tarlinton</name><affiliation><nlm:aff id="aff3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Vazquez, Aime" sort="Vazquez, Aime" uniqKey="Vazquez A" first="Aimé" last="Vazquez">Aimé Vazquez</name><affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21868573</idno><idno type="pmc">3204730</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204730</idno><idno type="RBID">PMC:3204730</idno><idno type="doi">10.1182/blood-2011-04-347096</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001792</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001792</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Regulation of memory B-cell survival by the BH3-only protein Puma</title><author><name sortKey="Clybouw, Cyril" sort="Clybouw, Cyril" uniqKey="Clybouw C" first="Cyril" last="Clybouw">Cyril Clybouw</name><affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Fischer, Silke" sort="Fischer, Silke" uniqKey="Fischer S" first="Silke" last="Fischer">Silke Fischer</name><affiliation><nlm:aff id="aff3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Auffredou, Marie Therese" sort="Auffredou, Marie Therese" uniqKey="Auffredou M" first="Marie Thérèse" last="Auffredou">Marie Thérèse Auffredou</name><affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Hugues, Patricia" sort="Hugues, Patricia" uniqKey="Hugues P" first="Patricia" last="Hugues">Patricia Hugues</name><affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Inserm UMR-S 802 and Assistance Publique–Hôpitanx de Paris Hopital Bicêtre, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Alexia, Catherine" sort="Alexia, Catherine" uniqKey="Alexia C" first="Catherine" last="Alexia">Catherine Alexia</name><affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Bouillet, Philippe" sort="Bouillet, Philippe" uniqKey="Bouillet P" first="Philippe" last="Bouillet">Philippe Bouillet</name><affiliation><nlm:aff id="aff3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Raphael, Martine" sort="Raphael, Martine" uniqKey="Raphael M" first="Martine" last="Raphael">Martine Raphael</name><affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Inserm UMR-S 802 and Assistance Publique–Hôpitanx de Paris Hopital Bicêtre, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Leca, Gerald" sort="Leca, Gerald" uniqKey="Leca G" first="Gérald" last="Leca">Gérald Leca</name><affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff></affiliation></author><author><name sortKey="Strasser, Andreas" sort="Strasser, Andreas" uniqKey="Strasser A" first="Andreas" last="Strasser">Andreas Strasser</name><affiliation><nlm:aff id="aff3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Tarlinton, David M" sort="Tarlinton, David M" uniqKey="Tarlinton D" first="David M." last="Tarlinton">David M. Tarlinton</name><affiliation><nlm:aff id="aff3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Vazquez, Aime" sort="Vazquez, Aime" uniqKey="Vazquez A" first="Aimé" last="Vazquez">Aimé Vazquez</name><affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Apoptosis is crucial for immune system homeostasis, including selection and survival of long-lived antibody-forming cells and memory cells. The interactions between proapoptotic and pro-survival proteins of the Bcl-2 family are critical for this process. In this report, we show that expression of the proapoptotic BH3-only Bcl-2 family member Puma was selectively up-regulated on in vitro activation with antigens or mitogens of both human and mouse B cells. Puma expression coincided in vivo, with the prosurvival Bcl-2 family member Mcl-1 within the germinal centers and its expression correlates with the germinal center like phenotype of Burkitt lymphoma. Experiments performed in Puma-deficient mice revealed that Puma is essential for apoptosis of mitogen-activated B cells in vitro and for the control of memory B-cell survival. In conclusion, using both human and murine models, our data show that Puma has a major role in the T cell– dependent B-cell immune response. These data demonstrate that Puma is a major regulator of memory B lymphocyte survival and therefore a key molecule in the control of the immune response.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id><journal-id journal-id-type="hwp">bloodjournal</journal-id><journal-id journal-id-type="pmc">blood</journal-id><journal-id journal-id-type="publisher-id">Blood</journal-id><journal-title-group><journal-title>Blood</journal-title></journal-title-group><issn pub-type="ppub">0006-4971</issn><issn pub-type="epub">1528-0020</issn><publisher><publisher-name>American Society of Hematology</publisher-name><publisher-loc>Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21868573</article-id><article-id pub-id-type="pmc">3204730</article-id><article-id pub-id-type="publisher-id">2011/347096</article-id><article-id pub-id-type="doi">10.1182/blood-2011-04-347096</article-id><article-categories><subj-group subj-group-type="heading"><subject>Immunobiology</subject></subj-group></article-categories><title-group><article-title>Regulation of memory B-cell survival by the BH3-only protein Puma</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Clybouw</surname><given-names>Cyril</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2"></xref><xref ref-type="aff" rid="aff3"></xref><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Fischer</surname><given-names>Silke</given-names></name><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Auffredou</surname><given-names>Marie Thérèse</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hugues</surname><given-names>Patricia</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Alexia</surname><given-names>Catherine</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Bouillet</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Raphael</surname><given-names>Martine</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Leca</surname><given-names>Gérald</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Strasser</surname><given-names>Andreas</given-names></name><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="author-notes" rid="FN2">†</xref></contrib><contrib contrib-type="author"><name><surname>Tarlinton</surname><given-names>David M.</given-names></name><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="author-notes" rid="FN2">†</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Vazquez</surname><given-names>Aimé</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="author-notes" rid="FN2">†</xref></contrib><aff id="aff1"><label>1</label>Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</aff><aff id="aff2"><label>2</label>Université Paris-Sud, Paris, France;</aff><aff id="aff3"><label>3</label>The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</aff><aff id="aff4"><label>4</label>Department of Medical Biology, Melbourne University, Melbourne, Australia; and</aff><aff id="aff5"><label>5</label>Inserm UMR-S 802 and Assistance Publique–Hôpitanx de Paris Hopital Bicêtre, Paris, France</aff></contrib-group><author-notes><fn fn-type="other" id="FN1"><label>*</label><p>C.C. and S.F. share first authorship.</p></fn><fn fn-type="equal" id="FN2"><label>†</label><p>A.S., D.M.T., and A.V. contributed equally to this article.</p></fn></author-notes><pub-date pub-type="ppub"><day>13</day><month>10</month><year>2011</year></pub-date><pub-date pub-type="epreprint"><day>25</day><month>8</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>13</day><month>10</month><year>2012</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>118</volume><issue>15</issue><fpage>4120</fpage><lpage>4128</lpage><history><date date-type="received"><day>6</day><month>4</month><year>2011</year></date><date date-type="accepted"><day>19</day><month>7</month><year>2011</year></date></history><permissions><copyright-statement>© 2011 by The American Society of Hematology</copyright-statement><copyright-year>2011</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zh804111004120.pdf"></self-uri><abstract><p>Apoptosis is crucial for immune system homeostasis, including selection and survival of long-lived antibody-forming cells and memory cells. The interactions between proapoptotic and pro-survival proteins of the Bcl-2 family are critical for this process. In this report, we show that expression of the proapoptotic BH3-only Bcl-2 family member Puma was selectively up-regulated on in vitro activation with antigens or mitogens of both human and mouse B cells. Puma expression coincided in vivo, with the prosurvival Bcl-2 family member Mcl-1 within the germinal centers and its expression correlates with the germinal center like phenotype of Burkitt lymphoma. Experiments performed in Puma-deficient mice revealed that Puma is essential for apoptosis of mitogen-activated B cells in vitro and for the control of memory B-cell survival. In conclusion, using both human and murine models, our data show that Puma has a major role in the T cell– dependent B-cell immune response. These data demonstrate that Puma is a major regulator of memory B lymphocyte survival and therefore a key molecule in the control of the immune response.</p></abstract><funding-group><award-group><funding-source id="CS100">National Institutes of Health</funding-source><award-id rid="CS100">CA80188</award-id><award-id rid="CS100">CA43540</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001792 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001792 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |