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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Regulation of memory B-cell survival by the BH3-only protein Puma</title>
<author><name sortKey="Clybouw, Cyril" sort="Clybouw, Cyril" uniqKey="Clybouw C" first="Cyril" last="Clybouw">Cyril Clybouw</name>
<affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fischer, Silke" sort="Fischer, Silke" uniqKey="Fischer S" first="Silke" last="Fischer">Silke Fischer</name>
<affiliation><nlm:aff id="aff3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Auffredou, Marie Therese" sort="Auffredou, Marie Therese" uniqKey="Auffredou M" first="Marie Thérèse" last="Auffredou">Marie Thérèse Auffredou</name>
<affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hugues, Patricia" sort="Hugues, Patricia" uniqKey="Hugues P" first="Patricia" last="Hugues">Patricia Hugues</name>
<affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Inserm UMR-S 802 and Assistance Publique–Hôpitanx de Paris Hopital Bicêtre, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Alexia, Catherine" sort="Alexia, Catherine" uniqKey="Alexia C" first="Catherine" last="Alexia">Catherine Alexia</name>
<affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bouillet, Philippe" sort="Bouillet, Philippe" uniqKey="Bouillet P" first="Philippe" last="Bouillet">Philippe Bouillet</name>
<affiliation><nlm:aff id="aff3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Raphael, Martine" sort="Raphael, Martine" uniqKey="Raphael M" first="Martine" last="Raphael">Martine Raphael</name>
<affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Inserm UMR-S 802 and Assistance Publique–Hôpitanx de Paris Hopital Bicêtre, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Leca, Gerald" sort="Leca, Gerald" uniqKey="Leca G" first="Gérald" last="Leca">Gérald Leca</name>
<affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Strasser, Andreas" sort="Strasser, Andreas" uniqKey="Strasser A" first="Andreas" last="Strasser">Andreas Strasser</name>
<affiliation><nlm:aff id="aff3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tarlinton, David M" sort="Tarlinton, David M" uniqKey="Tarlinton D" first="David M." last="Tarlinton">David M. Tarlinton</name>
<affiliation><nlm:aff id="aff3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vazquez, Aime" sort="Vazquez, Aime" uniqKey="Vazquez A" first="Aimé" last="Vazquez">Aimé Vazquez</name>
<affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21868573</idno>
<idno type="pmc">3204730</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204730</idno>
<idno type="RBID">PMC:3204730</idno>
<idno type="doi">10.1182/blood-2011-04-347096</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">001792</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001792</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Regulation of memory B-cell survival by the BH3-only protein Puma</title>
<author><name sortKey="Clybouw, Cyril" sort="Clybouw, Cyril" uniqKey="Clybouw C" first="Cyril" last="Clybouw">Cyril Clybouw</name>
<affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fischer, Silke" sort="Fischer, Silke" uniqKey="Fischer S" first="Silke" last="Fischer">Silke Fischer</name>
<affiliation><nlm:aff id="aff3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Auffredou, Marie Therese" sort="Auffredou, Marie Therese" uniqKey="Auffredou M" first="Marie Thérèse" last="Auffredou">Marie Thérèse Auffredou</name>
<affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hugues, Patricia" sort="Hugues, Patricia" uniqKey="Hugues P" first="Patricia" last="Hugues">Patricia Hugues</name>
<affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Inserm UMR-S 802 and Assistance Publique–Hôpitanx de Paris Hopital Bicêtre, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Alexia, Catherine" sort="Alexia, Catherine" uniqKey="Alexia C" first="Catherine" last="Alexia">Catherine Alexia</name>
<affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bouillet, Philippe" sort="Bouillet, Philippe" uniqKey="Bouillet P" first="Philippe" last="Bouillet">Philippe Bouillet</name>
<affiliation><nlm:aff id="aff3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Raphael, Martine" sort="Raphael, Martine" uniqKey="Raphael M" first="Martine" last="Raphael">Martine Raphael</name>
<affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Inserm UMR-S 802 and Assistance Publique–Hôpitanx de Paris Hopital Bicêtre, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Leca, Gerald" sort="Leca, Gerald" uniqKey="Leca G" first="Gérald" last="Leca">Gérald Leca</name>
<affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Strasser, Andreas" sort="Strasser, Andreas" uniqKey="Strasser A" first="Andreas" last="Strasser">Andreas Strasser</name>
<affiliation><nlm:aff id="aff3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tarlinton, David M" sort="Tarlinton, David M" uniqKey="Tarlinton D" first="David M." last="Tarlinton">David M. Tarlinton</name>
<affiliation><nlm:aff id="aff3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Medical Biology, Melbourne University, Melbourne, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vazquez, Aime" sort="Vazquez, Aime" uniqKey="Vazquez A" first="Aimé" last="Vazquez">Aimé Vazquez</name>
<affiliation><nlm:aff id="aff1">Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Université Paris-Sud, Paris, France;</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Blood</title>
<idno type="ISSN">0006-4971</idno>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Apoptosis is crucial for immune system homeostasis, including selection and survival of long-lived antibody-forming cells and memory cells. The interactions between proapoptotic and pro-survival proteins of the Bcl-2 family are critical for this process. In this report, we show that expression of the proapoptotic BH3-only Bcl-2 family member Puma was selectively up-regulated on in vitro activation with antigens or mitogens of both human and mouse B cells. Puma expression coincided in vivo, with the prosurvival Bcl-2 family member Mcl-1 within the germinal centers and its expression correlates with the germinal center like phenotype of Burkitt lymphoma. Experiments performed in Puma-deficient mice revealed that Puma is essential for apoptosis of mitogen-activated B cells in vitro and for the control of memory B-cell survival. In conclusion, using both human and murine models, our data show that Puma has a major role in the T cell– dependent B-cell immune response. These data demonstrate that Puma is a major regulator of memory B lymphocyte survival and therefore a key molecule in the control of the immune response.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id>
<journal-id journal-id-type="hwp">bloodjournal</journal-id>
<journal-id journal-id-type="pmc">blood</journal-id>
<journal-id journal-id-type="publisher-id">Blood</journal-id>
<journal-title-group><journal-title>Blood</journal-title>
</journal-title-group>
<issn pub-type="ppub">0006-4971</issn>
<issn pub-type="epub">1528-0020</issn>
<publisher><publisher-name>American Society of Hematology</publisher-name>
<publisher-loc>Washington, DC</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21868573</article-id>
<article-id pub-id-type="pmc">3204730</article-id>
<article-id pub-id-type="publisher-id">2011/347096</article-id>
<article-id pub-id-type="doi">10.1182/blood-2011-04-347096</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Immunobiology</subject>
</subj-group>
</article-categories>
<title-group><article-title>Regulation of memory B-cell survival by the BH3-only protein Puma</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Clybouw</surname>
<given-names>Cyril</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2"></xref>
<xref ref-type="aff" rid="aff3"></xref>
<xref ref-type="aff" rid="aff4">4</xref>
<xref ref-type="author-notes" rid="FN1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fischer</surname>
<given-names>Silke</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
<xref ref-type="aff" rid="aff4">4</xref>
<xref ref-type="author-notes" rid="FN1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Auffredou</surname>
<given-names>Marie Thérèse</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hugues</surname>
<given-names>Patricia</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Alexia</surname>
<given-names>Catherine</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bouillet</surname>
<given-names>Philippe</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Raphael</surname>
<given-names>Martine</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leca</surname>
<given-names>Gérald</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Strasser</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
<xref ref-type="aff" rid="aff4">4</xref>
<xref ref-type="author-notes" rid="FN2">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tarlinton</surname>
<given-names>David M.</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
<xref ref-type="aff" rid="aff4">4</xref>
<xref ref-type="author-notes" rid="FN2">†</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Vazquez</surname>
<given-names>Aimé</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="author-notes" rid="FN2">†</xref>
</contrib>
<aff id="aff1"><label>1</label>
Inserm Unité Mixte de Recherche (UMR)-S 1014, Villejuif, France;</aff>
<aff id="aff2"><label>2</label>
Université Paris-Sud, Paris, France;</aff>
<aff id="aff3"><label>3</label>
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;</aff>
<aff id="aff4"><label>4</label>
Department of Medical Biology, Melbourne University, Melbourne, Australia; and</aff>
<aff id="aff5"><label>5</label>
Inserm UMR-S 802 and Assistance Publique–Hôpitanx de Paris Hopital Bicêtre, Paris, France</aff>
</contrib-group>
<author-notes><fn fn-type="other" id="FN1"><label>*</label>
<p>C.C. and S.F. share first authorship.</p>
</fn>
<fn fn-type="equal" id="FN2"><label>†</label>
<p>A.S., D.M.T., and A.V. contributed equally to this article.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>13</day>
<month>10</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epreprint"><day>25</day>
<month>8</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>13</day>
<month>10</month>
<year>2012</year>
</pub-date>
<pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
. </pmc-comment>
<volume>118</volume>
<issue>15</issue>
<fpage>4120</fpage>
<lpage>4128</lpage>
<history><date date-type="received"><day>6</day>
<month>4</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>19</day>
<month>7</month>
<year>2011</year>
</date>
</history>
<permissions><copyright-statement>© 2011 by The American Society of Hematology</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zh804111004120.pdf"></self-uri>
<abstract><p>Apoptosis is crucial for immune system homeostasis, including selection and survival of long-lived antibody-forming cells and memory cells. The interactions between proapoptotic and pro-survival proteins of the Bcl-2 family are critical for this process. In this report, we show that expression of the proapoptotic BH3-only Bcl-2 family member Puma was selectively up-regulated on in vitro activation with antigens or mitogens of both human and mouse B cells. Puma expression coincided in vivo, with the prosurvival Bcl-2 family member Mcl-1 within the germinal centers and its expression correlates with the germinal center like phenotype of Burkitt lymphoma. Experiments performed in Puma-deficient mice revealed that Puma is essential for apoptosis of mitogen-activated B cells in vitro and for the control of memory B-cell survival. In conclusion, using both human and murine models, our data show that Puma has a major role in the T cell– dependent B-cell immune response. These data demonstrate that Puma is a major regulator of memory B lymphocyte survival and therefore a key molecule in the control of the immune response.</p>
</abstract>
<funding-group><award-group><funding-source id="CS100">National Institutes of Health</funding-source>
<award-id rid="CS100">CA80188</award-id>
<award-id rid="CS100">CA43540</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>
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