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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Emergence of form from function—Mechanical engineering approaches to probe the role of stem cell mechanoadaptation in sealing cell fate</title><author><name sortKey="Knothe Tate, Melissa L" sort="Knothe Tate, Melissa L" uniqKey="Knothe Tate M" first="Melissa L." last="Knothe Tate">Melissa L. Knothe Tate</name><affiliation><nlm:aff id="af0001"><institution>Graduate School of Biomedical Engineering, University of New South Wales</institution>, Sydney,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Gunning, Peter W" sort="Gunning, Peter W" uniqKey="Gunning P" first="Peter W." last="Gunning">Peter W. Gunning</name><affiliation><nlm:aff id="af0002"><institution>School of Medical Sciences, University of New South Wales</institution>, Sydney,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Sansalone, Vittorio" sort="Sansalone, Vittorio" uniqKey="Sansalone V" first="Vittorio" last="Sansalone">Vittorio Sansalone</name><affiliation><nlm:aff id="af0003"><institution>Université Paris-Est Créteil (UPEC), Laboratoire Modélisation et Simulation Multi Echelle</institution>,<addr-line>MSME UMR 8208 CNRS</addr-line>, Créteil,<country>France</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27739911</idno><idno type="pmc">5077068</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077068</idno><idno type="RBID">PMC:5077068</idno><idno type="doi">10.1080/19490992.2016.1229729</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001760</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001760</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Emergence of form from function—Mechanical engineering approaches to probe the role of stem cell mechanoadaptation in sealing cell fate</title><author><name sortKey="Knothe Tate, Melissa L" sort="Knothe Tate, Melissa L" uniqKey="Knothe Tate M" first="Melissa L." last="Knothe Tate">Melissa L. Knothe Tate</name><affiliation><nlm:aff id="af0001"><institution>Graduate School of Biomedical Engineering, University of New South Wales</institution>, Sydney,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Gunning, Peter W" sort="Gunning, Peter W" uniqKey="Gunning P" first="Peter W." last="Gunning">Peter W. Gunning</name><affiliation><nlm:aff id="af0002"><institution>School of Medical Sciences, University of New South Wales</institution>, Sydney,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Sansalone, Vittorio" sort="Sansalone, Vittorio" uniqKey="Sansalone V" first="Vittorio" last="Sansalone">Vittorio Sansalone</name><affiliation><nlm:aff id="af0003"><institution>Université Paris-Est Créteil (UPEC), Laboratoire Modélisation et Simulation Multi Echelle</institution>,<addr-line>MSME UMR 8208 CNRS</addr-line>, Créteil,<country>France</country></nlm:aff></affiliation></author></analytic><series><title level="j">Bioarchitecture</title><idno type="ISSN">1949-0992</idno><idno type="eISSN">1949-100X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>Stem cell “mechanomics” refers to the effect of mechanical cues on stem cell and matrix biology, where cell shape and fate are intrinsic manifestations of form and function. Before specialization, the stem cell itself serves as a sensor and actuator; its structure emerges from its local mechanical <italic>milieu</italic> as the cell adapts over time. Coupling of novel spatiotemporal imaging and computational methods allows for linking of the energy of adaptation to the structure, biology and mechanical function of the cell. Cutting edge imaging methods enable probing of mechanisms by which stem cells' emergent anisotropic architecture and fate commitment occurs. A novel cell-scale model provides a mechanistic framework to describe stem cell growth and remodeling through mechanical feedback; making use of a generalized virtual power principle, the model accounts for the rate of doing work or the rate of using energy to effect the work. This coupled approach provides a basis to elucidate mechanisms underlying the stem cell's innate capacity to adapt to mechanical stimuli as well as the role of mechanoadaptation in lineage commitment. An understanding of stem cell mechanoadaptation is key to deciphering lineage commitment, during prenatal development, postnatal wound healing, and engineering of tissues.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Bioarchitecture</journal-id><journal-id journal-id-type="iso-abbrev">Bioarchitecture</journal-id><journal-id journal-id-type="publisher-id">KBIA</journal-id><journal-id journal-id-type="publisher-id">kbia20</journal-id><journal-title-group><journal-title>Bioarchitecture</journal-title></journal-title-group><issn pub-type="ppub">1949-0992</issn><issn pub-type="epub">1949-100X</issn><publisher><publisher-name>Taylor & Francis</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27739911</article-id><article-id pub-id-type="pmc">5077068</article-id><article-id pub-id-type="publisher-id">1229729</article-id><article-id pub-id-type="doi">10.1080/19490992.2016.1229729</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Paper</subject></subj-group></article-categories><title-group><article-title>Emergence of form from function—Mechanical engineering approaches to probe the role of stem cell mechanoadaptation in sealing cell fate</article-title><alt-title alt-title-type="running-authors">Knothe Tate et al.</alt-title><alt-title alt-title-type="running-title">SEALING STEM CELL FATE THROUGH MECHANOADAPTATION</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Knothe Tate</surname><given-names>Melissa L.</given-names></name><xref ref-type="aff" rid="af0001"><sup>a</sup></xref><xref ref-type="corresp" rid="an0001"></xref></contrib><contrib contrib-type="author"><name><surname>Gunning</surname><given-names>Peter W.</given-names></name><xref ref-type="aff" rid="af0002"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sansalone</surname><given-names>Vittorio</given-names></name><xref ref-type="aff" rid="af0003"><sup>c</sup></xref></contrib><aff id="af0001"><label>a</label><institution>Graduate School of Biomedical Engineering, University of New South Wales</institution>, Sydney,<country>Australia</country></aff><aff id="af0002"><label>b</label><institution>School of Medical Sciences, University of New South Wales</institution>, Sydney,<country>Australia</country></aff><aff id="af0003"><label>c</label><institution>Université Paris-Est Créteil (UPEC), Laboratoire Modélisation et Simulation Multi Echelle</institution>,<addr-line>MSME UMR 8208 CNRS</addr-line>, Créteil,<country>France</country></aff></contrib-group><author-notes><corresp id="an0001">Correspondence to: Melissa L. Knothe Tate, PhD, <institution>Graduate School of Biomedical Engineering, University of New South Wales</institution>, <addr-line>Samuels 509, UNSW Sydney 2052 NSW</addr-line>, <country>Australia</country> Email: <email xlink:href="m.knothetate@unsw.edu.au">m.knothetate@unsw.edu.au</email></corresp><fn><p>Color versions of one or more of the figures in this article can be found online at <ext-link ext-link-type="uri" xlink:href="http://www.tandfonline.com/kbia">www.tandfonline.com/kbia.</ext-link></p></fn></author-notes><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>14</day><month>10</month><year>2016</year></pub-date><volume>6</volume><issue>5</issue><fpage seq="1">85</fpage><lpage>103</lpage><history><date date-type="received"><day>21</day><month>8</month><year>2015</year></date><date date-type="rev-recd"><day>6</day><month>1</month><year>2016</year></date><date date-type="accepted"><day>16</day><month>1</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 Taylor & Francis</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Taylor & Francis</copyright-holder></permissions><self-uri content-type="pdf" xlink:href="kbia-06-05-1229729.pdf"></self-uri><abstract><title>ABSTRACT</title><p>Stem cell “mechanomics” refers to the effect of mechanical cues on stem cell and matrix biology, where cell shape and fate are intrinsic manifestations of form and function. Before specialization, the stem cell itself serves as a sensor and actuator; its structure emerges from its local mechanical <italic>milieu</italic> as the cell adapts over time. Coupling of novel spatiotemporal imaging and computational methods allows for linking of the energy of adaptation to the structure, biology and mechanical function of the cell. Cutting edge imaging methods enable probing of mechanisms by which stem cells' emergent anisotropic architecture and fate commitment occurs. A novel cell-scale model provides a mechanistic framework to describe stem cell growth and remodeling through mechanical feedback; making use of a generalized virtual power principle, the model accounts for the rate of doing work or the rate of using energy to effect the work. This coupled approach provides a basis to elucidate mechanisms underlying the stem cell's innate capacity to adapt to mechanical stimuli as well as the role of mechanoadaptation in lineage commitment. An understanding of stem cell mechanoadaptation is key to deciphering lineage commitment, during prenatal development, postnatal wound healing, and engineering of tissues.</p></abstract><kwd-group kwd-group-type="author"><title>KEYWORDS</title><kwd>cell mechanics</kwd><kwd>fate</kwd><kwd>lineage commitment</kwd><kwd>mechanoadaptation</kwd><kwd>mechanomics</kwd><kwd>stem cell</kwd></kwd-group><counts><fig-count count="7"></fig-count><table-count count="1"></table-count><ref-count count="83"></ref-count><page-count count="19"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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