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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium</title><author><name sortKey="Bosetti, C" sort="Bosetti, C" uniqKey="Bosetti C" first="C." last="Bosetti">C. Bosetti</name><affiliation><nlm:aff id="mdu276_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS - Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Rosato, V" sort="Rosato, V" uniqKey="Rosato V" first="V." last="Rosato">V. Rosato</name><affiliation><nlm:aff id="mdu276_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS - Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Li, D" sort="Li, D" uniqKey="Li D" first="D." last="Li">D. Li</name><affiliation><nlm:aff id="mdu276_af2"><addr-line>M.D. Anderson Cancer Center</addr-line>,<institution>University of Texas</institution>,<addr-line>Houston</addr-line></nlm:aff></affiliation></author><author><name sortKey="Silverman, D" sort="Silverman, D" uniqKey="Silverman D" first="D." last="Silverman">D. Silverman</name><affiliation><nlm:aff id="mdu276_af3"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda</addr-line></nlm:aff></affiliation></author><author><name sortKey="Petersen, G M" sort="Petersen, G M" uniqKey="Petersen G" first="G. M." last="Petersen">G. M. Petersen</name><affiliation><nlm:aff id="mdu276_af4"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Medicine and Medical Genetics</institution>,<addr-line>Mayo Clinic, Rochester</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bracci, P M" sort="Bracci, P M" uniqKey="Bracci P" first="P. M." last="Bracci">P. M. Bracci</name><affiliation><nlm:aff id="mdu276_af5"><institution>Department of Epidemiology and Biostatistics, University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Neale, R E" sort="Neale, R E" uniqKey="Neale R" first="R. E." last="Neale">R. E. Neale</name><affiliation><nlm:aff id="mdu276_af6"><institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Muscat, J" sort="Muscat, J" uniqKey="Muscat J" first="J." last="Muscat">J. Muscat</name><affiliation><nlm:aff id="mdu276_af7"><addr-line>Department of Public Health Sciences</addr-line>,<institution>Penn State University</institution>,<addr-line>Penn State</addr-line></nlm:aff></affiliation></author><author><name sortKey="Anderson, K" sort="Anderson, K" uniqKey="Anderson K" first="K." last="Anderson">K. Anderson</name><affiliation><nlm:aff id="mdu276_af8"><addr-line>Division of Epidemiology and Community Health</addr-line>,<institution>University of Minnesota</institution>,<addr-line>Minneapolis</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Gallinger, S" sort="Gallinger, S" uniqKey="Gallinger S" first="S." last="Gallinger">S. Gallinger</name><affiliation><nlm:aff id="mdu276_af9"><addr-line>University Health Network, Department of Surgery</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Olson, S H" sort="Olson, S H" uniqKey="Olson S" first="S. H." last="Olson">S. H. Olson</name><affiliation><nlm:aff id="mdu276_af10"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Memorial Sloan Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Miller, A B" sort="Miller, A B" uniqKey="Miller A" first="A. B." last="Miller">A. B. Miller</name><affiliation><nlm:aff id="mdu276_af11"><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Bas Bueno De Mesquita, H" sort="Bas Bueno De Mesquita, H" uniqKey="Bas Bueno De Mesquita H" first="H." last="Bas Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation><nlm:aff id="mdu276_af12"><institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>Bilthoven</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="mdu276_af13"><addr-line>Department of Gastroenterology and Hepatology</addr-line>,<institution>University Medical Center Utrecht (UMCU)</institution>,<addr-line>Utrecht</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation><affiliation><nlm:aff id="mdu276_af14"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>School of Public Health, Imperial College London</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Scelo, G" sort="Scelo, G" uniqKey="Scelo G" first="G." last="Scelo">G. Scelo</name><affiliation><nlm:aff id="mdu276_af15"><institution>International Agency for Research on Cancer (IARC)</institution>,<addr-line>Lyon</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Janout, V" sort="Janout, V" uniqKey="Janout V" first="V." last="Janout">V. Janout</name><affiliation><nlm:aff id="mdu276_af16"><addr-line>Department of Preventive Medicine, Faculty of Medicine</addr-line>,<institution>Palacky University</institution>,<addr-line>Olomouc</addr-line></nlm:aff></affiliation></author><author><name sortKey="Holcatova, I" sort="Holcatova, I" uniqKey="Holcatova I" first="I." last="Holcatova">I. Holcatova</name><affiliation><nlm:aff id="mdu276_af17"><addr-line>Institute of Hygiene and Epidemiology, 1st Faculty of Medicine</addr-line>,<institution>Charles University in Prague</institution>,<addr-line>Prague</addr-line>,<country>Czech Republic</country></nlm:aff></affiliation></author><author><name sortKey="Lagiou, P" sort="Lagiou, P" uniqKey="Lagiou P" first="P." last="Lagiou">P. Lagiou</name><affiliation><nlm:aff id="mdu276_af18"><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="mdu276_af19"><addr-line>Department of Hygiene, Epidemiology and Medical Statistics</addr-line>,<institution>School of Medicine, University of Athens</institution>,<addr-line>Athens</addr-line>,<country>Greece</country></nlm:aff></affiliation></author><author><name sortKey="Serraino, D" sort="Serraino, D" uniqKey="Serraino D" first="D." last="Serraino">D. Serraino</name><affiliation><nlm:aff id="mdu276_af20"><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>CRO Aviano National Cancer Institute, IRCCS</institution>,<addr-line>Aviano</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lucenteforte, E" sort="Lucenteforte, E" uniqKey="Lucenteforte E" first="E." last="Lucenteforte">E. Lucenteforte</name><affiliation><nlm:aff id="mdu276_af21"><addr-line>Department of Preclinical and Clinical Pharmacology Mario Aiazzi Mancini</addr-line>,<institution>Università degli Studi di Firenze</institution>,<addr-line>Florence</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Fabianova, E" sort="Fabianova, E" uniqKey="Fabianova E" first="E." last="Fabianova">E. Fabianova</name><affiliation><nlm:aff id="mdu276_af22"><institution>Regional Authority of Public Health in Banská Bystrica</institution>,<addr-line>Banská Bystrica</addr-line>,<country>Slovakia</country></nlm:aff></affiliation></author><author><name sortKey="Ghadirian, P" sort="Ghadirian, P" uniqKey="Ghadirian P" first="P." last="Ghadirian">P. Ghadirian</name></author><author><name sortKey="Baghurst, P A" sort="Baghurst, P A" uniqKey="Baghurst P" first="P. A." last="Baghurst">P. A. Baghurst</name><affiliation><nlm:aff id="mdu276_af23"><addr-line>Public Health</addr-line>,<institution>Women's and Children's Hospital</institution>,<addr-line>Adelaide, SA</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Zatonski, W" sort="Zatonski, W" uniqKey="Zatonski W" first="W." last="Zatonski">W. Zatonski</name><affiliation><nlm:aff id="mdu276_af24"><institution>Cancer Center and Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Foretova, L" sort="Foretova, L" uniqKey="Foretova L" first="L." last="Foretova">L. Foretova</name><affiliation><nlm:aff id="mdu276_af25"><addr-line>Department of Cancer Epidemiology and Genetics</addr-line>,<institution>Masaryk Memorial Cancer Institute, Institute and MF MU</institution>,<addr-line>Brno</addr-line>,<country>Czech Republic</country></nlm:aff></affiliation></author><author><name sortKey="Fontham, E" sort="Fontham, E" uniqKey="Fontham E" first="E." last="Fontham">E. Fontham</name><affiliation><nlm:aff id="mdu276_af26"><institution>Louisiana State University School of Public Health</institution>,<addr-line>New Orleans</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Bamlet, W R" sort="Bamlet, W R" uniqKey="Bamlet W" first="W. R." last="Bamlet">W. R. Bamlet</name><affiliation><nlm:aff id="mdu276_af4"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Medicine and Medical Genetics</institution>,<addr-line>Mayo Clinic, Rochester</addr-line></nlm:aff></affiliation></author><author><name sortKey="Holly, E A" sort="Holly, E A" uniqKey="Holly E" first="E. A." last="Holly">E. A. Holly</name><affiliation><nlm:aff id="mdu276_af5"><institution>Department of Epidemiology and Biostatistics, University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E." last="Negri">E. Negri</name><affiliation><nlm:aff id="mdu276_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS - Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Hassan, M" sort="Hassan, M" uniqKey="Hassan M" first="M." last="Hassan">M. Hassan</name><affiliation><nlm:aff id="mdu276_af2"><addr-line>M.D. Anderson Cancer Center</addr-line>,<institution>University of Texas</institution>,<addr-line>Houston</addr-line></nlm:aff></affiliation></author><author><name sortKey="Prizment, A" sort="Prizment, A" uniqKey="Prizment A" first="A." last="Prizment">A. Prizment</name><affiliation><nlm:aff id="mdu276_af8"><addr-line>Division of Epidemiology and Community Health</addr-line>,<institution>University of Minnesota</institution>,<addr-line>Minneapolis</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Cotterchio, M" sort="Cotterchio, M" uniqKey="Cotterchio M" first="M." last="Cotterchio">M. Cotterchio</name><affiliation><nlm:aff id="mdu276_af11"><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="mdu276_af27"><institution>Cancer Care Ontario</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Cleary, S" sort="Cleary, S" uniqKey="Cleary S" first="S." last="Cleary">S. Cleary</name><affiliation><nlm:aff id="mdu276_af9"><addr-line>University Health Network, Department of Surgery</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Kurtz, R C" sort="Kurtz, R C" uniqKey="Kurtz R" first="R. C." last="Kurtz">R. C. Kurtz</name><affiliation><nlm:aff id="mdu276_af28"><addr-line>Department of Medicine</addr-line>,<institution>Memorial Sloan Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Maisonneuve, P" sort="Maisonneuve, P" uniqKey="Maisonneuve P" first="P." last="Maisonneuve">P. Maisonneuve</name><affiliation><nlm:aff id="mdu276_af29"><addr-line>Division of Epidemiology and Biostatistics</addr-line>,<institution>European Institute of Oncology</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Trichopoulos, D" sort="Trichopoulos, D" uniqKey="Trichopoulos D" first="D." last="Trichopoulos">D. Trichopoulos</name><affiliation><nlm:aff id="mdu276_af18"><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J." last="Polesel">J. Polesel</name><affiliation><nlm:aff id="mdu276_af20"><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>CRO Aviano National Cancer Institute, IRCCS</institution>,<addr-line>Aviano</addr-line></nlm:aff></affiliation></author><author><name sortKey="Duell, E J" sort="Duell, E J" uniqKey="Duell E" first="E. J." last="Duell">E. J. Duell</name><affiliation><nlm:aff id="mdu276_af30"><addr-line>Unit of Nutrition, Environment and Cancer</addr-line>,<institution>Catalan Institute of Oncology (ICO-IDIBELL), L'Hospitalet de Llobregat</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name><affiliation><nlm:aff id="mdu276_af31"><institution>The Tisch Cancer Institute and Institute for Translational Epidemiology</institution>,<institution>Icahn School of Medicine at Mount Sinai</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C." last="La Vecchia">C. La Vecchia</name><affiliation><nlm:aff id="mdu276_af32"><addr-line>Department of Clinical Sciences and Community Health</addr-line>,<institution>Università degli Studi di Milano</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25057164</idno><idno type="pmc">4176453</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176453</idno><idno type="RBID">PMC:4176453</idno><idno type="doi">10.1093/annonc/mdu276</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001738</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001738</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium</title><author><name sortKey="Bosetti, C" sort="Bosetti, C" uniqKey="Bosetti C" first="C." last="Bosetti">C. Bosetti</name><affiliation><nlm:aff id="mdu276_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS - Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Rosato, V" sort="Rosato, V" uniqKey="Rosato V" first="V." last="Rosato">V. Rosato</name><affiliation><nlm:aff id="mdu276_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS - Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Li, D" sort="Li, D" uniqKey="Li D" first="D." last="Li">D. Li</name><affiliation><nlm:aff id="mdu276_af2"><addr-line>M.D. Anderson Cancer Center</addr-line>,<institution>University of Texas</institution>,<addr-line>Houston</addr-line></nlm:aff></affiliation></author><author><name sortKey="Silverman, D" sort="Silverman, D" uniqKey="Silverman D" first="D." last="Silverman">D. Silverman</name><affiliation><nlm:aff id="mdu276_af3"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda</addr-line></nlm:aff></affiliation></author><author><name sortKey="Petersen, G M" sort="Petersen, G M" uniqKey="Petersen G" first="G. M." last="Petersen">G. M. Petersen</name><affiliation><nlm:aff id="mdu276_af4"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Medicine and Medical Genetics</institution>,<addr-line>Mayo Clinic, Rochester</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bracci, P M" sort="Bracci, P M" uniqKey="Bracci P" first="P. M." last="Bracci">P. M. Bracci</name><affiliation><nlm:aff id="mdu276_af5"><institution>Department of Epidemiology and Biostatistics, University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Neale, R E" sort="Neale, R E" uniqKey="Neale R" first="R. E." last="Neale">R. E. Neale</name><affiliation><nlm:aff id="mdu276_af6"><institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Muscat, J" sort="Muscat, J" uniqKey="Muscat J" first="J." last="Muscat">J. Muscat</name><affiliation><nlm:aff id="mdu276_af7"><addr-line>Department of Public Health Sciences</addr-line>,<institution>Penn State University</institution>,<addr-line>Penn State</addr-line></nlm:aff></affiliation></author><author><name sortKey="Anderson, K" sort="Anderson, K" uniqKey="Anderson K" first="K." last="Anderson">K. Anderson</name><affiliation><nlm:aff id="mdu276_af8"><addr-line>Division of Epidemiology and Community Health</addr-line>,<institution>University of Minnesota</institution>,<addr-line>Minneapolis</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Gallinger, S" sort="Gallinger, S" uniqKey="Gallinger S" first="S." last="Gallinger">S. Gallinger</name><affiliation><nlm:aff id="mdu276_af9"><addr-line>University Health Network, Department of Surgery</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Olson, S H" sort="Olson, S H" uniqKey="Olson S" first="S. H." last="Olson">S. H. Olson</name><affiliation><nlm:aff id="mdu276_af10"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Memorial Sloan Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Miller, A B" sort="Miller, A B" uniqKey="Miller A" first="A. B." last="Miller">A. B. Miller</name><affiliation><nlm:aff id="mdu276_af11"><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Bas Bueno De Mesquita, H" sort="Bas Bueno De Mesquita, H" uniqKey="Bas Bueno De Mesquita H" first="H." last="Bas Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation><nlm:aff id="mdu276_af12"><institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>Bilthoven</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="mdu276_af13"><addr-line>Department of Gastroenterology and Hepatology</addr-line>,<institution>University Medical Center Utrecht (UMCU)</institution>,<addr-line>Utrecht</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation><affiliation><nlm:aff id="mdu276_af14"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>School of Public Health, Imperial College London</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Scelo, G" sort="Scelo, G" uniqKey="Scelo G" first="G." last="Scelo">G. Scelo</name><affiliation><nlm:aff id="mdu276_af15"><institution>International Agency for Research on Cancer (IARC)</institution>,<addr-line>Lyon</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Janout, V" sort="Janout, V" uniqKey="Janout V" first="V." last="Janout">V. Janout</name><affiliation><nlm:aff id="mdu276_af16"><addr-line>Department of Preventive Medicine, Faculty of Medicine</addr-line>,<institution>Palacky University</institution>,<addr-line>Olomouc</addr-line></nlm:aff></affiliation></author><author><name sortKey="Holcatova, I" sort="Holcatova, I" uniqKey="Holcatova I" first="I." last="Holcatova">I. Holcatova</name><affiliation><nlm:aff id="mdu276_af17"><addr-line>Institute of Hygiene and Epidemiology, 1st Faculty of Medicine</addr-line>,<institution>Charles University in Prague</institution>,<addr-line>Prague</addr-line>,<country>Czech Republic</country></nlm:aff></affiliation></author><author><name sortKey="Lagiou, P" sort="Lagiou, P" uniqKey="Lagiou P" first="P." last="Lagiou">P. Lagiou</name><affiliation><nlm:aff id="mdu276_af18"><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="mdu276_af19"><addr-line>Department of Hygiene, Epidemiology and Medical Statistics</addr-line>,<institution>School of Medicine, University of Athens</institution>,<addr-line>Athens</addr-line>,<country>Greece</country></nlm:aff></affiliation></author><author><name sortKey="Serraino, D" sort="Serraino, D" uniqKey="Serraino D" first="D." last="Serraino">D. Serraino</name><affiliation><nlm:aff id="mdu276_af20"><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>CRO Aviano National Cancer Institute, IRCCS</institution>,<addr-line>Aviano</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lucenteforte, E" sort="Lucenteforte, E" uniqKey="Lucenteforte E" first="E." last="Lucenteforte">E. Lucenteforte</name><affiliation><nlm:aff id="mdu276_af21"><addr-line>Department of Preclinical and Clinical Pharmacology Mario Aiazzi Mancini</addr-line>,<institution>Università degli Studi di Firenze</institution>,<addr-line>Florence</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Fabianova, E" sort="Fabianova, E" uniqKey="Fabianova E" first="E." last="Fabianova">E. Fabianova</name><affiliation><nlm:aff id="mdu276_af22"><institution>Regional Authority of Public Health in Banská Bystrica</institution>,<addr-line>Banská Bystrica</addr-line>,<country>Slovakia</country></nlm:aff></affiliation></author><author><name sortKey="Ghadirian, P" sort="Ghadirian, P" uniqKey="Ghadirian P" first="P." last="Ghadirian">P. Ghadirian</name></author><author><name sortKey="Baghurst, P A" sort="Baghurst, P A" uniqKey="Baghurst P" first="P. A." last="Baghurst">P. A. Baghurst</name><affiliation><nlm:aff id="mdu276_af23"><addr-line>Public Health</addr-line>,<institution>Women's and Children's Hospital</institution>,<addr-line>Adelaide, SA</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Zatonski, W" sort="Zatonski, W" uniqKey="Zatonski W" first="W." last="Zatonski">W. Zatonski</name><affiliation><nlm:aff id="mdu276_af24"><institution>Cancer Center and Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Foretova, L" sort="Foretova, L" uniqKey="Foretova L" first="L." last="Foretova">L. Foretova</name><affiliation><nlm:aff id="mdu276_af25"><addr-line>Department of Cancer Epidemiology and Genetics</addr-line>,<institution>Masaryk Memorial Cancer Institute, Institute and MF MU</institution>,<addr-line>Brno</addr-line>,<country>Czech Republic</country></nlm:aff></affiliation></author><author><name sortKey="Fontham, E" sort="Fontham, E" uniqKey="Fontham E" first="E." last="Fontham">E. Fontham</name><affiliation><nlm:aff id="mdu276_af26"><institution>Louisiana State University School of Public Health</institution>,<addr-line>New Orleans</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Bamlet, W R" sort="Bamlet, W R" uniqKey="Bamlet W" first="W. R." last="Bamlet">W. R. Bamlet</name><affiliation><nlm:aff id="mdu276_af4"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Medicine and Medical Genetics</institution>,<addr-line>Mayo Clinic, Rochester</addr-line></nlm:aff></affiliation></author><author><name sortKey="Holly, E A" sort="Holly, E A" uniqKey="Holly E" first="E. A." last="Holly">E. A. Holly</name><affiliation><nlm:aff id="mdu276_af5"><institution>Department of Epidemiology and Biostatistics, University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E." last="Negri">E. Negri</name><affiliation><nlm:aff id="mdu276_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS - Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Hassan, M" sort="Hassan, M" uniqKey="Hassan M" first="M." last="Hassan">M. Hassan</name><affiliation><nlm:aff id="mdu276_af2"><addr-line>M.D. Anderson Cancer Center</addr-line>,<institution>University of Texas</institution>,<addr-line>Houston</addr-line></nlm:aff></affiliation></author><author><name sortKey="Prizment, A" sort="Prizment, A" uniqKey="Prizment A" first="A." last="Prizment">A. Prizment</name><affiliation><nlm:aff id="mdu276_af8"><addr-line>Division of Epidemiology and Community Health</addr-line>,<institution>University of Minnesota</institution>,<addr-line>Minneapolis</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Cotterchio, M" sort="Cotterchio, M" uniqKey="Cotterchio M" first="M." last="Cotterchio">M. Cotterchio</name><affiliation><nlm:aff id="mdu276_af11"><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="mdu276_af27"><institution>Cancer Care Ontario</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Cleary, S" sort="Cleary, S" uniqKey="Cleary S" first="S." last="Cleary">S. Cleary</name><affiliation><nlm:aff id="mdu276_af9"><addr-line>University Health Network, Department of Surgery</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Kurtz, R C" sort="Kurtz, R C" uniqKey="Kurtz R" first="R. C." last="Kurtz">R. C. Kurtz</name><affiliation><nlm:aff id="mdu276_af28"><addr-line>Department of Medicine</addr-line>,<institution>Memorial Sloan Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Maisonneuve, P" sort="Maisonneuve, P" uniqKey="Maisonneuve P" first="P." last="Maisonneuve">P. Maisonneuve</name><affiliation><nlm:aff id="mdu276_af29"><addr-line>Division of Epidemiology and Biostatistics</addr-line>,<institution>European Institute of Oncology</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Trichopoulos, D" sort="Trichopoulos, D" uniqKey="Trichopoulos D" first="D." last="Trichopoulos">D. Trichopoulos</name><affiliation><nlm:aff id="mdu276_af18"><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J." last="Polesel">J. Polesel</name><affiliation><nlm:aff id="mdu276_af20"><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>CRO Aviano National Cancer Institute, IRCCS</institution>,<addr-line>Aviano</addr-line></nlm:aff></affiliation></author><author><name sortKey="Duell, E J" sort="Duell, E J" uniqKey="Duell E" first="E. J." last="Duell">E. J. Duell</name><affiliation><nlm:aff id="mdu276_af30"><addr-line>Unit of Nutrition, Environment and Cancer</addr-line>,<institution>Catalan Institute of Oncology (ICO-IDIBELL), L'Hospitalet de Llobregat</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name><affiliation><nlm:aff id="mdu276_af31"><institution>The Tisch Cancer Institute and Institute for Translational Epidemiology</institution>,<institution>Icahn School of Medicine at Mount Sinai</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C." last="La Vecchia">C. La Vecchia</name><affiliation><nlm:aff id="mdu276_af32"><addr-line>Department of Clinical Sciences and Community Health</addr-line>,<institution>Università degli Studi di Milano</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author></analytic><series><title level="j">Annals of Oncology</title><idno type="ISSN">0923-7534</idno><idno type="eISSN">1569-8041</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>This study confirms a twofold excess risk of pancreatic cancer in diabetics and shows that a 30% excess risk persists more than two decades after diabetes diagnosis, supporting a causal role of diabetes in pancreatic cancer. Oral antidiabetics may decrease pancreatic cancer risk, whereas insulin showed an inconsistent time-related association.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Ann Oncol</journal-id><journal-id journal-id-type="iso-abbrev">Ann. Oncol</journal-id><journal-id journal-id-type="publisher-id">annonc</journal-id><journal-id journal-id-type="hwp">annonc</journal-id><journal-title-group><journal-title>Annals of Oncology</journal-title></journal-title-group><issn pub-type="ppub">0923-7534</issn><issn pub-type="epub">1569-8041</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25057164</article-id><article-id pub-id-type="pmc">4176453</article-id><article-id pub-id-type="doi">10.1093/annonc/mdu276</article-id><article-id pub-id-type="publisher-id">mdu276</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject><subj-group subj-group-type="overline"><subject>Epidemiology</subject></subj-group></subj-group></article-categories><title-group><article-title>Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bosetti</surname><given-names>C.</given-names></name><xref ref-type="aff" rid="mdu276_af1">1</xref><xref ref-type="corresp" rid="mdu276_cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Rosato</surname><given-names>V.</given-names></name><xref ref-type="aff" rid="mdu276_af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="mdu276_af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Silverman</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="mdu276_af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Petersen</surname><given-names>G. M.</given-names></name><xref ref-type="aff" rid="mdu276_af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Bracci</surname><given-names>P. M.</given-names></name><xref ref-type="aff" rid="mdu276_af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Neale</surname><given-names>R. E.</given-names></name><xref ref-type="aff" rid="mdu276_af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Muscat</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="mdu276_af7">7</xref></contrib><contrib contrib-type="author"><name><surname>Anderson</surname><given-names>K.</given-names></name><xref ref-type="aff" rid="mdu276_af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Gallinger</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="mdu276_af9">9</xref></contrib><contrib contrib-type="author"><name><surname>Olson</surname><given-names>S. H.</given-names></name><xref ref-type="aff" rid="mdu276_af10">10</xref></contrib><contrib contrib-type="author"><name><surname>Miller</surname><given-names>A. B.</given-names></name><xref ref-type="aff" rid="mdu276_af11">11</xref></contrib><contrib contrib-type="author"><name><surname>Bas Bueno-de-Mesquita</surname><given-names>H.</given-names></name><xref ref-type="aff" rid="mdu276_af12">12</xref><xref ref-type="aff" rid="mdu276_af13">13</xref><xref ref-type="aff" rid="mdu276_af14">14</xref></contrib><contrib contrib-type="author"><name><surname>Scelo</surname><given-names>G.</given-names></name><xref ref-type="aff" rid="mdu276_af15">15</xref></contrib><contrib contrib-type="author"><name><surname>Janout</surname><given-names>V.</given-names></name><xref ref-type="aff" rid="mdu276_af16">16</xref></contrib><contrib contrib-type="author"><name><surname>Holcatova</surname><given-names>I.</given-names></name><xref ref-type="aff" rid="mdu276_af17">17</xref></contrib><contrib contrib-type="author"><name><surname>Lagiou</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="mdu276_af18">18</xref><xref ref-type="aff" rid="mdu276_af19">19</xref></contrib><contrib contrib-type="author"><name><surname>Serraino</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="mdu276_af20">20</xref></contrib><contrib contrib-type="author"><name><surname>Lucenteforte</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="mdu276_af21">21</xref></contrib><contrib contrib-type="author"><name><surname>Fabianova</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="mdu276_af22">22</xref></contrib><contrib contrib-type="author"><name><surname>Ghadirian</surname><given-names>P.</given-names></name><xref ref-type="author-notes" rid="mdu276_AN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Baghurst</surname><given-names>P. A.</given-names></name><xref ref-type="aff" rid="mdu276_af23">23</xref></contrib><contrib contrib-type="author"><name><surname>Zatonski</surname><given-names>W.</given-names></name><xref ref-type="aff" rid="mdu276_af24">24</xref></contrib><contrib contrib-type="author"><name><surname>Foretova</surname><given-names>L.</given-names></name><xref ref-type="aff" rid="mdu276_af25">25</xref></contrib><contrib contrib-type="author"><name><surname>Fontham</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="mdu276_af26">26</xref></contrib><contrib contrib-type="author"><name><surname>Bamlet</surname><given-names>W. R.</given-names></name><xref ref-type="aff" rid="mdu276_af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Holly</surname><given-names>E. A.</given-names></name><xref ref-type="aff" rid="mdu276_af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Negri</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="mdu276_af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hassan</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="mdu276_af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Prizment</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="mdu276_af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Cotterchio</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="mdu276_af11">11</xref><xref ref-type="aff" rid="mdu276_af27">27</xref></contrib><contrib contrib-type="author"><name><surname>Cleary</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="mdu276_af9">9</xref></contrib><contrib contrib-type="author"><name><surname>Kurtz</surname><given-names>R. C.</given-names></name><xref ref-type="aff" rid="mdu276_af28">28</xref></contrib><contrib contrib-type="author"><name><surname>Maisonneuve</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="mdu276_af29">29</xref></contrib><contrib contrib-type="author"><name><surname>Trichopoulos</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="mdu276_af18">18</xref></contrib><contrib contrib-type="author"><name><surname>Polesel</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="mdu276_af20">20</xref></contrib><contrib contrib-type="author"><name><surname>Duell</surname><given-names>E. J.</given-names></name><xref ref-type="aff" rid="mdu276_af30">30</xref></contrib><contrib contrib-type="author"><name><surname>Boffetta</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="mdu276_af31">31</xref></contrib><contrib contrib-type="author"><name><surname>La Vecchia</surname><given-names>C.</given-names></name><xref ref-type="aff" rid="mdu276_af32">32</xref></contrib><aff id="mdu276_af1"><label>1</label><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS - Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></aff><aff id="mdu276_af2"><label>2</label><addr-line>M.D. Anderson Cancer Center</addr-line>,<institution>University of Texas</institution>,<addr-line>Houston</addr-line></aff><aff id="mdu276_af3"><label>3</label><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda</addr-line></aff><aff id="mdu276_af4"><label>4</label><addr-line>Department of Health Sciences Research</addr-line>,<institution>Medicine and Medical Genetics</institution>,<addr-line>Mayo Clinic, Rochester</addr-line></aff><aff id="mdu276_af5"><label>5</label><institution>Department of Epidemiology and Biostatistics, University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></aff><aff id="mdu276_af6"><label>6</label><institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></aff><aff id="mdu276_af7"><label>7</label><addr-line>Department of Public Health Sciences</addr-line>,<institution>Penn State University</institution>,<addr-line>Penn State</addr-line></aff><aff id="mdu276_af8"><label>8</label><addr-line>Division of Epidemiology and Community Health</addr-line>,<institution>University of Minnesota</institution>,<addr-line>Minneapolis</addr-line>,<country>USA</country></aff><aff id="mdu276_af9"><label>9</label><addr-line>University Health Network, Department of Surgery</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></aff><aff id="mdu276_af10"><label>10</label><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Memorial Sloan Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></aff><aff id="mdu276_af11"><label>11</label><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></aff><aff id="mdu276_af12"><label>12</label><institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>Bilthoven</addr-line></aff><aff id="mdu276_af13"><label>13</label><addr-line>Department of Gastroenterology and Hepatology</addr-line>,<institution>University Medical Center Utrecht (UMCU)</institution>,<addr-line>Utrecht</addr-line>,<country>The Netherlands</country></aff><aff id="mdu276_af14"><label>14</label><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>School of Public Health, Imperial College London</institution>,<addr-line>London</addr-line>,<country>UK</country></aff><aff id="mdu276_af15"><label>15</label><institution>International Agency for Research on Cancer (IARC)</institution>,<addr-line>Lyon</addr-line>,<country>France</country></aff><aff id="mdu276_af16"><label>16</label><addr-line>Department of Preventive Medicine, Faculty of Medicine</addr-line>,<institution>Palacky University</institution>,<addr-line>Olomouc</addr-line></aff><aff id="mdu276_af17"><label>17</label><addr-line>Institute of Hygiene and Epidemiology, 1st Faculty of Medicine</addr-line>,<institution>Charles University in Prague</institution>,<addr-line>Prague</addr-line>,<country>Czech Republic</country></aff><aff id="mdu276_af18"><label>18</label><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<country>USA</country></aff><aff id="mdu276_af19"><label>19</label><addr-line>Department of Hygiene, Epidemiology and Medical Statistics</addr-line>,<institution>School of Medicine, University of Athens</institution>,<addr-line>Athens</addr-line>,<country>Greece</country></aff><aff id="mdu276_af20"><label>20</label><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>CRO Aviano National Cancer Institute, IRCCS</institution>,<addr-line>Aviano</addr-line></aff><aff id="mdu276_af21"><label>21</label><addr-line>Department of Preclinical and Clinical Pharmacology Mario Aiazzi Mancini</addr-line>,<institution>Università degli Studi di Firenze</institution>,<addr-line>Florence</addr-line>,<country>Italy</country></aff><aff id="mdu276_af22"><label>22</label><institution>Regional Authority of Public Health in Banská Bystrica</institution>,<addr-line>Banská Bystrica</addr-line>,<country>Slovakia</country></aff><aff id="mdu276_af23"><label>23</label><addr-line>Public Health</addr-line>,<institution>Women's and Children's Hospital</institution>,<addr-line>Adelaide, SA</addr-line>,<country>Australia</country></aff><aff id="mdu276_af24"><label>24</label><institution>Cancer Center and Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></aff><aff id="mdu276_af25"><label>25</label><addr-line>Department of Cancer Epidemiology and Genetics</addr-line>,<institution>Masaryk Memorial Cancer Institute, Institute and MF MU</institution>,<addr-line>Brno</addr-line>,<country>Czech Republic</country></aff><aff id="mdu276_af26"><label>26</label><institution>Louisiana State University School of Public Health</institution>,<addr-line>New Orleans</addr-line>,<country>USA</country></aff><aff id="mdu276_af27"><label>27</label><institution>Cancer Care Ontario</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></aff><aff id="mdu276_af28"><label>28</label><addr-line>Department of Medicine</addr-line>,<institution>Memorial Sloan Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></aff><aff id="mdu276_af29"><label>29</label><addr-line>Division of Epidemiology and Biostatistics</addr-line>,<institution>European Institute of Oncology</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></aff><aff id="mdu276_af30"><label>30</label><addr-line>Unit of Nutrition, Environment and Cancer</addr-line>,<institution>Catalan Institute of Oncology (ICO-IDIBELL), L'Hospitalet de Llobregat</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></aff><aff id="mdu276_af31"><label>31</label><institution>The Tisch Cancer Institute and Institute for Translational Epidemiology</institution>,<institution>Icahn School of Medicine at Mount Sinai</institution>,<addr-line>New York</addr-line>,<country>USA</country></aff><aff id="mdu276_af32"><label>32</label><addr-line>Department of Clinical Sciences and Community Health</addr-line>,<institution>Università degli Studi di Milano</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></aff></contrib-group><author-notes><corresp id="mdu276_cor1"><label>*</label><italic>Correspondence to:</italic> Dr Cristina Bosetti, Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via La Masa 19, 2056 Milan, Italy. Tel: +39-0239014-526; Fax: +<fax>39-33200231</fax>; E-mail: <email>cristina.bosetti@marionegri.it</email></corresp><fn id="mdu276_AN1"><label>†</label><p>Deceased.</p></fn></author-notes><pub-date pub-type="ppub"><month>10</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>23</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>10</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>25</volume><issue>10</issue><fpage>2065</fpage><lpage>2072</lpage><history><date date-type="received"><day>19</day><month>5</month><year>2014</year></date><date date-type="rev-recd"><day>30</day><month>6</month><year>2014</year></date><date date-type="accepted"><day>1</day><month>7</month><year>2014</year></date></history><permissions><copyright-statement>© The Author 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</copyright-statement><copyright-year>2014</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="mdu276.pdf"></self-uri><abstract abstract-type="precis"><p>This study confirms a twofold excess risk of pancreatic cancer in diabetics and shows that a 30% excess risk persists more than two decades after diabetes diagnosis, supporting a causal role of diabetes in pancreatic cancer. Oral antidiabetics may decrease pancreatic cancer risk, whereas insulin showed an inconsistent time-related association.</p></abstract><abstract><sec><title>Background</title><p>Type 2 diabetes mellitus has been associated with an excess risk of pancreatic cancer, but the magnitude of the risk and the time–risk relationship are unclear, and there is limited information on the role of antidiabetic medications.</p></sec><sec><title>Patients and methods</title><p>We analyzed individual-level data from 15 case–control studies within the Pancreatic Cancer Case-Control Consortium, including 8305 cases and 13 987 controls. Pooled odds ratios (ORs) were estimated from multiple logistic regression models, adjusted for relevant covariates.</p></sec><sec><title>Results</title><p>Overall, 1155 (15%) cases and 1087 (8%) controls reported a diagnosis of diabetes 2 or more years before cancer diagnosis (or interview, for controls), corresponding to an OR of 1.90 (95% confidence interval, CI, 1.72–2.09). Consistent risk estimates were observed across strata of selected covariates, including body mass index and tobacco smoking. Pancreatic cancer risk decreased with duration of diabetes, but a significant excess risk was still evident 20 or more years after diabetes diagnosis (OR 1.30, 95% CI 1.03–1.63). Among diabetics, long duration of oral antidiabetic use was associated with a decreased pancreatic cancer risk (OR 0.31, 95% CI 0.14–0.69, for ≥15 years). Conversely, insulin use was associated with a pancreatic cancer risk in the short term (OR 5.60, 95% CI 3.75–8.35, for <5 years), but not for longer duration of use (OR 0.95, 95% CI 0.53–1.70, for ≥15 years).</p></sec><sec><title>Conclusion</title><p>This study provides the most definitive quantification to date of an excess risk of pancreatic cancer among diabetics. It also shows that a 30% excess risk persists for more than two decades after diabetes diagnosis, thus supporting a causal role of diabetes in pancreatic cancer. Oral antidiabetics may decrease the risk of pancreatic cancer, whereas insulin showed an inconsistent duration–risk relationship.</p></sec></abstract><kwd-group><kwd>oral antidiabetics</kwd><kwd>case–control study</kwd><kwd>diabetes</kwd><kwd>insulin</kwd><kwd>pancreatic cancer</kwd><kwd>pooled analysis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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