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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case–Control Consortium (PanC4)</title><author><name sortKey="Bosetti, C" sort="Bosetti, C" uniqKey="Bosetti C" first="C." last="Bosetti">C. Bosetti</name><affiliation><nlm:aff id="mdt336_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS, Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lucenteforte, E" sort="Lucenteforte, E" uniqKey="Lucenteforte E" first="E." last="Lucenteforte">E. Lucenteforte</name><affiliation><nlm:aff id="mdt336_af2"><addr-line>Department of Preclinical and Clinical Pharmacology ‘Mario Aiazzi Mancini’</addr-line>,<institution>Università degli Studi di Firenze</institution>,<addr-line>Florence</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Bracci, P M" sort="Bracci, P M" uniqKey="Bracci P" first="P. M." last="Bracci">P. M. Bracci</name><affiliation><nlm:aff id="mdt336_af3"><institution>University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E." last="Negri">E. Negri</name><affiliation><nlm:aff id="mdt336_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS, Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Neale, R E" sort="Neale, R E" uniqKey="Neale R" first="R. E." last="Neale">R. E. Neale</name><affiliation><nlm:aff id="mdt336_af4"><addr-line>Cancer and Population Studies Group</addr-line>,<institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Risch, H A" sort="Risch, H A" uniqKey="Risch H" first="H. A." last="Risch">H. A. Risch</name><affiliation><nlm:aff id="mdt336_af5"><addr-line>Department of Epidemiology and Public Health</addr-line>,<institution>Yale School of Public Health</institution>,<addr-line>New Haven</addr-line></nlm:aff></affiliation></author><author><name sortKey="Olson, S H" sort="Olson, S H" uniqKey="Olson S" first="S. H." last="Olson">S. H. Olson</name><affiliation><nlm:aff id="mdt336_af6"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Memorial Sloan-Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Gallinger, S" sort="Gallinger, S" uniqKey="Gallinger S" first="S." last="Gallinger">S. Gallinger</name><affiliation><nlm:aff id="mdt336_af7"><institution>Toronto General Hospital</institution>,<addr-line>Toronto</addr-line></nlm:aff></affiliation></author><author><name sortKey="Miller, A B" sort="Miller, A B" uniqKey="Miller A" first="A. B." last="Miller">A. B. Miller</name><affiliation><nlm:aff id="mdt336_af8"><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H. B." last="Bueno-De-Mesquita">H. B. Bueno-De-Mesquita</name><affiliation><nlm:aff id="mdt336_af9"><institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>Bilthoven</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="mdt336_af10"><addr-line>Department of Gastroenterology and Hepatology</addr-line>,<institution>University Medical Center Utrecht (UMCU)</institution>,<addr-line>Utrecht</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Talamini, R" sort="Talamini, R" uniqKey="Talamini R" first="R." last="Talamini">R. Talamini</name><affiliation><nlm:aff id="mdt336_af11"><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>Centro di Riferimento Oncologico (CRO)–National Cancer Institute</institution>,<addr-line>Aviano</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J." last="Polesel">J. Polesel</name><affiliation><nlm:aff id="mdt336_af11"><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>Centro di Riferimento Oncologico (CRO)–National Cancer Institute</institution>,<addr-line>Aviano</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Ghadirian, P" sort="Ghadirian, P" uniqKey="Ghadirian P" first="P." last="Ghadirian">P. Ghadirian</name><affiliation><nlm:aff id="mdt336_af12"><addr-line>Epidemiology Research Unit</addr-line>,<institution>Research Centre (CRCHUM)</institution>,<addr-line>Montréal</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Baghurst, P A" sort="Baghurst, P A" uniqKey="Baghurst P" first="P. A." last="Baghurst">P. A. Baghurst</name><affiliation><nlm:aff id="mdt336_af13"><addr-line>Public Health</addr-line>,<institution>Women's and Children's Hospital</institution>,<addr-line>Adelaide SA</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Zatonski, W" sort="Zatonski, W" uniqKey="Zatonski W" first="W." last="Zatonski">W. Zatonski</name><affiliation><nlm:aff id="mdt336_af14"><institution>Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Fontham, E" sort="Fontham, E" uniqKey="Fontham E" first="E." last="Fontham">E. Fontham</name><affiliation><nlm:aff id="mdt336_af15"><institution>Louisiana State University School of Public Health</institution>,<addr-line>New Orleans</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Holly, E A" sort="Holly, E A" uniqKey="Holly E" first="E. A." last="Holly">E. A. Holly</name><affiliation><nlm:aff id="mdt336_af3"><institution>University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Gao, Y T" sort="Gao, Y T" uniqKey="Gao Y" first="Y. T." last="Gao">Y. T. Gao</name><affiliation><nlm:aff id="mdt336_af16"><institution>Shanghai Cancer Institute</institution>,<addr-line>Shanghai</addr-line>,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Yu, H" sort="Yu, H" uniqKey="Yu H" first="H." last="Yu">H. Yu</name><affiliation><nlm:aff id="mdt336_af5"><addr-line>Department of Epidemiology and Public Health</addr-line>,<institution>Yale School of Public Health</institution>,<addr-line>New Haven</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="mdt336_af17"><addr-line>Cancer Epidemiology Program</addr-line>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Kurtz, R C" sort="Kurtz, R C" uniqKey="Kurtz R" first="R. C." last="Kurtz">R. C. Kurtz</name><affiliation><nlm:aff id="mdt336_af6"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Memorial Sloan-Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Cotterchio, M" sort="Cotterchio, M" uniqKey="Cotterchio M" first="M." last="Cotterchio">M. Cotterchio</name><affiliation><nlm:aff id="mdt336_af8"><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="mdt336_af18"><institution>Cancer Care Ontario</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Maisonneuve, P" sort="Maisonneuve, P" uniqKey="Maisonneuve P" first="P." last="Maisonneuve">P. Maisonneuve</name><affiliation><nlm:aff id="mdt336_af19"><institution>European Institute of Oncology</institution>,<addr-line>Milano</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Zeegers, M P" sort="Zeegers, M P" uniqKey="Zeegers M" first="M. P." last="Zeegers">M. P. Zeegers</name><affiliation><nlm:aff id="mdt336_af20"><addr-line>Unit of Complex Genetics, Department of Genetics and Cell Biology, NUTRIM School for Nutrition, Toxicology and Metabolism</addr-line>,<institution>Maastricht University Medical Centre</institution>,<addr-line>Maastricht</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Duell, E J" sort="Duell, E J" uniqKey="Duell E" first="E. J." last="Duell">E. J. Duell</name><affiliation><nlm:aff id="mdt336_af21"><addr-line>Unit of Nutrition, Environment and Cancer</addr-line>,<institution>Catalan Institute of Oncology (ICO-IDIBELL)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name><affiliation><nlm:aff id="mdt336_af22"><addr-line>The Tisch Cancer Institute and Institute for Translational Epidemiology</addr-line>,<institution>Mount Sinai School of Medicine</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="mdt336_af23"><institution>International Prevention Research Institute</institution>,<addr-line>Lyon</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C." last="La Vecchia">C. La Vecchia</name><affiliation><nlm:aff id="mdt336_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS, Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="mdt336_af24"><addr-line>Department of Clinical Sciences and Community Health</addr-line>,<institution>University of Milan</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23970016</idno><idno type="pmc">3811904</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811904</idno><idno type="RBID">PMC:3811904</idno><idno type="doi">10.1093/annonc/mdt336</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001737</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001737</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case–Control Consortium (PanC4)</title><author><name sortKey="Bosetti, C" sort="Bosetti, C" uniqKey="Bosetti C" first="C." last="Bosetti">C. Bosetti</name><affiliation><nlm:aff id="mdt336_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS, Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lucenteforte, E" sort="Lucenteforte, E" uniqKey="Lucenteforte E" first="E." last="Lucenteforte">E. Lucenteforte</name><affiliation><nlm:aff id="mdt336_af2"><addr-line>Department of Preclinical and Clinical Pharmacology ‘Mario Aiazzi Mancini’</addr-line>,<institution>Università degli Studi di Firenze</institution>,<addr-line>Florence</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Bracci, P M" sort="Bracci, P M" uniqKey="Bracci P" first="P. M." last="Bracci">P. M. Bracci</name><affiliation><nlm:aff id="mdt336_af3"><institution>University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E." last="Negri">E. Negri</name><affiliation><nlm:aff id="mdt336_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS, Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line></nlm:aff></affiliation></author><author><name sortKey="Neale, R E" sort="Neale, R E" uniqKey="Neale R" first="R. E." last="Neale">R. E. Neale</name><affiliation><nlm:aff id="mdt336_af4"><addr-line>Cancer and Population Studies Group</addr-line>,<institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Risch, H A" sort="Risch, H A" uniqKey="Risch H" first="H. A." last="Risch">H. A. Risch</name><affiliation><nlm:aff id="mdt336_af5"><addr-line>Department of Epidemiology and Public Health</addr-line>,<institution>Yale School of Public Health</institution>,<addr-line>New Haven</addr-line></nlm:aff></affiliation></author><author><name sortKey="Olson, S H" sort="Olson, S H" uniqKey="Olson S" first="S. H." last="Olson">S. H. Olson</name><affiliation><nlm:aff id="mdt336_af6"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Memorial Sloan-Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Gallinger, S" sort="Gallinger, S" uniqKey="Gallinger S" first="S." last="Gallinger">S. Gallinger</name><affiliation><nlm:aff id="mdt336_af7"><institution>Toronto General Hospital</institution>,<addr-line>Toronto</addr-line></nlm:aff></affiliation></author><author><name sortKey="Miller, A B" sort="Miller, A B" uniqKey="Miller A" first="A. B." last="Miller">A. B. Miller</name><affiliation><nlm:aff id="mdt336_af8"><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H. B." last="Bueno-De-Mesquita">H. B. Bueno-De-Mesquita</name><affiliation><nlm:aff id="mdt336_af9"><institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>Bilthoven</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="mdt336_af10"><addr-line>Department of Gastroenterology and Hepatology</addr-line>,<institution>University Medical Center Utrecht (UMCU)</institution>,<addr-line>Utrecht</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Talamini, R" sort="Talamini, R" uniqKey="Talamini R" first="R." last="Talamini">R. Talamini</name><affiliation><nlm:aff id="mdt336_af11"><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>Centro di Riferimento Oncologico (CRO)–National Cancer Institute</institution>,<addr-line>Aviano</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J." last="Polesel">J. Polesel</name><affiliation><nlm:aff id="mdt336_af11"><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>Centro di Riferimento Oncologico (CRO)–National Cancer Institute</institution>,<addr-line>Aviano</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Ghadirian, P" sort="Ghadirian, P" uniqKey="Ghadirian P" first="P." last="Ghadirian">P. Ghadirian</name><affiliation><nlm:aff id="mdt336_af12"><addr-line>Epidemiology Research Unit</addr-line>,<institution>Research Centre (CRCHUM)</institution>,<addr-line>Montréal</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Baghurst, P A" sort="Baghurst, P A" uniqKey="Baghurst P" first="P. A." last="Baghurst">P. A. Baghurst</name><affiliation><nlm:aff id="mdt336_af13"><addr-line>Public Health</addr-line>,<institution>Women's and Children's Hospital</institution>,<addr-line>Adelaide SA</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Zatonski, W" sort="Zatonski, W" uniqKey="Zatonski W" first="W." last="Zatonski">W. Zatonski</name><affiliation><nlm:aff id="mdt336_af14"><institution>Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Fontham, E" sort="Fontham, E" uniqKey="Fontham E" first="E." last="Fontham">E. Fontham</name><affiliation><nlm:aff id="mdt336_af15"><institution>Louisiana State University School of Public Health</institution>,<addr-line>New Orleans</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Holly, E A" sort="Holly, E A" uniqKey="Holly E" first="E. A." last="Holly">E. A. Holly</name><affiliation><nlm:aff id="mdt336_af3"><institution>University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Gao, Y T" sort="Gao, Y T" uniqKey="Gao Y" first="Y. T." last="Gao">Y. T. Gao</name><affiliation><nlm:aff id="mdt336_af16"><institution>Shanghai Cancer Institute</institution>,<addr-line>Shanghai</addr-line>,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Yu, H" sort="Yu, H" uniqKey="Yu H" first="H." last="Yu">H. Yu</name><affiliation><nlm:aff id="mdt336_af5"><addr-line>Department of Epidemiology and Public Health</addr-line>,<institution>Yale School of Public Health</institution>,<addr-line>New Haven</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="mdt336_af17"><addr-line>Cancer Epidemiology Program</addr-line>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Kurtz, R C" sort="Kurtz, R C" uniqKey="Kurtz R" first="R. C." last="Kurtz">R. C. Kurtz</name><affiliation><nlm:aff id="mdt336_af6"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Memorial Sloan-Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Cotterchio, M" sort="Cotterchio, M" uniqKey="Cotterchio M" first="M." last="Cotterchio">M. Cotterchio</name><affiliation><nlm:aff id="mdt336_af8"><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="mdt336_af18"><institution>Cancer Care Ontario</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Maisonneuve, P" sort="Maisonneuve, P" uniqKey="Maisonneuve P" first="P." last="Maisonneuve">P. Maisonneuve</name><affiliation><nlm:aff id="mdt336_af19"><institution>European Institute of Oncology</institution>,<addr-line>Milano</addr-line>,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Zeegers, M P" sort="Zeegers, M P" uniqKey="Zeegers M" first="M. P." last="Zeegers">M. P. Zeegers</name><affiliation><nlm:aff id="mdt336_af20"><addr-line>Unit of Complex Genetics, Department of Genetics and Cell Biology, NUTRIM School for Nutrition, Toxicology and Metabolism</addr-line>,<institution>Maastricht University Medical Centre</institution>,<addr-line>Maastricht</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Duell, E J" sort="Duell, E J" uniqKey="Duell E" first="E. J." last="Duell">E. J. Duell</name><affiliation><nlm:aff id="mdt336_af21"><addr-line>Unit of Nutrition, Environment and Cancer</addr-line>,<institution>Catalan Institute of Oncology (ICO-IDIBELL)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></nlm:aff></affiliation></author><author><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name><affiliation><nlm:aff id="mdt336_af22"><addr-line>The Tisch Cancer Institute and Institute for Translational Epidemiology</addr-line>,<institution>Mount Sinai School of Medicine</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="mdt336_af23"><institution>International Prevention Research Institute</institution>,<addr-line>Lyon</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C." last="La Vecchia">C. La Vecchia</name><affiliation><nlm:aff id="mdt336_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS, Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="mdt336_af24"><addr-line>Department of Clinical Sciences and Community Health</addr-line>,<institution>University of Milan</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff></affiliation></author></analytic><series><title level="j">Annals of Oncology</title><idno type="ISSN">0923-7534</idno><idno type="eISSN">1569-8041</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Peptic ulcer and its treatments have been associated to pancreatic cancer risk, although the evidence is inconsistent.</p></sec><sec><title>Methods</title><p>We pooled 10 case–control studies within the Pancreatic Cancer Case–control Consortium (PanC4), including 4717 pancreatic cancer cases and 9374 controls, and estimated summary odds ratios (OR) using multivariable logistic regression models.</p></sec><sec><title>Results</title><p>The OR for pancreatic cancer was 1.10 [95% confidence interval (CI) 0.98–1.23] for history of ulcer (OR = 1.08 for gastric and 0.97 for duodenal ulcer). The association was stronger for a diagnosis within 2 years before cancer diagnosis (OR = 2.43 for peptic, 1.75 for gastric, and 1.98 for duodenal ulcer). The OR was 1.53 (95% CI 1.15–2.03) for history of gastrectomy; however, the excess risk was limited to a gastrectomy within 2 years before cancer diagnosis (OR = 6.18, 95% CI 1.82–20.96), while no significant increased risk was observed for longer time since gastrectomy. No associations were observed for pharmacological treatments for ulcer, such as antacids, H2-receptor antagonists, or proton-pump inhibitors.</p></sec><sec><title>Conclusions</title><p>This uniquely large collaborative study does not support the hypothesis that peptic ulcer and its treatment materially affect pancreatic cancer risk. The increased risk for short-term history of ulcer and gastrectomy suggests that any such association is due to increased cancer surveillance.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Ann Oncol</journal-id><journal-id journal-id-type="iso-abbrev">Ann. Oncol</journal-id><journal-id journal-id-type="publisher-id">annonc</journal-id><journal-id journal-id-type="hwp">annonc</journal-id><journal-title-group><journal-title>Annals of Oncology</journal-title></journal-title-group><issn pub-type="ppub">0923-7534</issn><issn pub-type="epub">1569-8041</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23970016</article-id><article-id pub-id-type="pmc">3811904</article-id><article-id pub-id-type="doi">10.1093/annonc/mdt336</article-id><article-id pub-id-type="publisher-id">mdt336</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject><subj-group subj-group-type="heading"><subject>Epidemiology</subject></subj-group></subj-group></article-categories><title-group><article-title>Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case–Control Consortium (PanC4)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bosetti</surname><given-names>C.</given-names></name><xref ref-type="aff" rid="mdt336_af1">1</xref><xref ref-type="corresp" rid="mdt336_cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Lucenteforte</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="mdt336_af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Bracci</surname><given-names>P. M.</given-names></name><xref ref-type="aff" rid="mdt336_af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Negri</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="mdt336_af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Neale</surname><given-names>R. E.</given-names></name><xref ref-type="aff" rid="mdt336_af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Risch</surname><given-names>H. A.</given-names></name><xref ref-type="aff" rid="mdt336_af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Olson</surname><given-names>S. H.</given-names></name><xref ref-type="aff" rid="mdt336_af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Gallinger</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="mdt336_af7">7</xref></contrib><contrib contrib-type="author"><name><surname>Miller</surname><given-names>A. B.</given-names></name><xref ref-type="aff" rid="mdt336_af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Bueno-de-Mesquita</surname><given-names>H. B.</given-names></name><xref ref-type="aff" rid="mdt336_af9">9</xref><xref ref-type="aff" rid="mdt336_af10">10</xref></contrib><contrib contrib-type="author"><name><surname>Talamini</surname><given-names>R.</given-names></name><xref ref-type="aff" rid="mdt336_af11">11</xref></contrib><contrib contrib-type="author"><name><surname>Polesel</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="mdt336_af11">11</xref></contrib><contrib contrib-type="author"><name><surname>Ghadirian</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="mdt336_af12">12</xref></contrib><contrib contrib-type="author"><name><surname>Baghurst</surname><given-names>P. A.</given-names></name><xref ref-type="aff" rid="mdt336_af13">13</xref></contrib><contrib contrib-type="author"><name><surname>Zatonski</surname><given-names>W.</given-names></name><xref ref-type="aff" rid="mdt336_af14">14</xref></contrib><contrib contrib-type="author"><name><surname>Fontham</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="mdt336_af15">15</xref></contrib><contrib contrib-type="author"><name><surname>Holly</surname><given-names>E. A.</given-names></name><xref ref-type="aff" rid="mdt336_af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Y. T.</given-names></name><xref ref-type="aff" rid="mdt336_af16">16</xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>H.</given-names></name><xref ref-type="aff" rid="mdt336_af5">5</xref><xref ref-type="aff" rid="mdt336_af17">17</xref></contrib><contrib contrib-type="author"><name><surname>Kurtz</surname><given-names>R. C.</given-names></name><xref ref-type="aff" rid="mdt336_af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Cotterchio</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="mdt336_af8">8</xref><xref ref-type="aff" rid="mdt336_af18">18</xref></contrib><contrib contrib-type="author"><name><surname>Maisonneuve</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="mdt336_af19">19</xref></contrib><contrib contrib-type="author"><name><surname>Zeegers</surname><given-names>M. P.</given-names></name><xref ref-type="aff" rid="mdt336_af20">20</xref></contrib><contrib contrib-type="author"><name><surname>Duell</surname><given-names>E. J.</given-names></name><xref ref-type="aff" rid="mdt336_af21">21</xref></contrib><contrib contrib-type="author"><name><surname>Boffetta</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="mdt336_af22">22</xref><xref ref-type="aff" rid="mdt336_af23">23</xref></contrib><contrib contrib-type="author"><name><surname>La Vecchia</surname><given-names>C.</given-names></name><xref ref-type="aff" rid="mdt336_af1">1</xref><xref ref-type="aff" rid="mdt336_af24">24</xref></contrib></contrib-group><aff id="mdt336_af1"><label>1</label><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS, Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line></aff><aff id="mdt336_af2"><label>2</label><addr-line>Department of Preclinical and Clinical Pharmacology ‘Mario Aiazzi Mancini’</addr-line>,<institution>Università degli Studi di Firenze</institution>,<addr-line>Florence</addr-line>,<country>Italy</country></aff><aff id="mdt336_af3"><label>3</label><institution>University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></aff><aff id="mdt336_af4"><label>4</label><addr-line>Cancer and Population Studies Group</addr-line>,<institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></aff><aff id="mdt336_af5"><label>5</label><addr-line>Department of Epidemiology and Public Health</addr-line>,<institution>Yale School of Public Health</institution>,<addr-line>New Haven</addr-line></aff><aff id="mdt336_af6"><label>6</label><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Memorial Sloan-Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></aff><aff id="mdt336_af7"><label>7</label><institution>Toronto General Hospital</institution>,<addr-line>Toronto</addr-line></aff><aff id="mdt336_af8"><label>8</label><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></aff><aff id="mdt336_af9"><label>9</label><institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>Bilthoven</addr-line></aff><aff id="mdt336_af10"><label>10</label><addr-line>Department of Gastroenterology and Hepatology</addr-line>,<institution>University Medical Center Utrecht (UMCU)</institution>,<addr-line>Utrecht</addr-line>,<country>The Netherlands</country></aff><aff id="mdt336_af11"><label>11</label><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>Centro di Riferimento Oncologico (CRO)–National Cancer Institute</institution>,<addr-line>Aviano</addr-line>,<country>Italy</country></aff><aff id="mdt336_af12"><label>12</label><addr-line>Epidemiology Research Unit</addr-line>,<institution>Research Centre (CRCHUM)</institution>,<addr-line>Montréal</addr-line>,<country>Canada</country></aff><aff id="mdt336_af13"><label>13</label><addr-line>Public Health</addr-line>,<institution>Women's and Children's Hospital</institution>,<addr-line>Adelaide SA</addr-line>,<country>Australia</country></aff><aff id="mdt336_af14"><label>14</label><institution>Cancer Center & Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></aff><aff id="mdt336_af15"><label>15</label><institution>Louisiana State University School of Public Health</institution>,<addr-line>New Orleans</addr-line>,<country>USA</country></aff><aff id="mdt336_af16"><label>16</label><institution>Shanghai Cancer Institute</institution>,<addr-line>Shanghai</addr-line>,<country>China</country></aff><aff id="mdt336_af17"><label>17</label><addr-line>Cancer Epidemiology Program</addr-line>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu</addr-line>,<country>USA</country></aff><aff id="mdt336_af18"><label>18</label><institution>Cancer Care Ontario</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></aff><aff id="mdt336_af19"><label>19</label><institution>European Institute of Oncology</institution>,<addr-line>Milano</addr-line>,<country>Italy</country></aff><aff id="mdt336_af20"><label>20</label><addr-line>Unit of Complex Genetics, Department of Genetics and Cell Biology, NUTRIM School for Nutrition, Toxicology and Metabolism</addr-line>,<institution>Maastricht University Medical Centre</institution>,<addr-line>Maastricht</addr-line>,<country>The Netherlands</country></aff><aff id="mdt336_af21"><label>21</label><addr-line>Unit of Nutrition, Environment and Cancer</addr-line>,<institution>Catalan Institute of Oncology (ICO-IDIBELL)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></aff><aff id="mdt336_af22"><label>22</label><addr-line>The Tisch Cancer Institute and Institute for Translational Epidemiology</addr-line>,<institution>Mount Sinai School of Medicine</institution>,<addr-line>New York</addr-line>,<country>USA</country></aff><aff id="mdt336_af23"><label>23</label><institution>International Prevention Research Institute</institution>,<addr-line>Lyon</addr-line>,<country>France</country></aff><aff id="mdt336_af24"><label>24</label><addr-line>Department of Clinical Sciences and Community Health</addr-line>,<institution>University of Milan</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></aff><author-notes><corresp id="mdt336_cor1"><label>*</label><italic>Correspondence to:</italic> Dr Cristina Bosetti, Department of Epidemiology, IRCCS, Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via La Masa 19-2056 Milan, Italy. Tel: +39-02-39014-526; Fax: +39-02-3320-0231; E-mail: <email>cristina.bosetti@marionegri.it</email></corresp></author-notes><pub-date pub-type="ppub"><month>11</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>22</day><month>8</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>11</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>24</volume><issue>11</issue><fpage>2903</fpage><lpage>2910</lpage><history><date date-type="received"><day>21</day><month>12</month><year>2012</year></date><date date-type="rev-recd"><day>5</day><month>7</month><year>2013</year></date><date date-type="accepted"><day>8</day><month>7</month><year>2013</year></date></history><permissions><copyright-statement>© The Author 2013. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="mdt336.pdf"></self-uri><abstract><sec><title>Background</title><p>Peptic ulcer and its treatments have been associated to pancreatic cancer risk, although the evidence is inconsistent.</p></sec><sec><title>Methods</title><p>We pooled 10 case–control studies within the Pancreatic Cancer Case–control Consortium (PanC4), including 4717 pancreatic cancer cases and 9374 controls, and estimated summary odds ratios (OR) using multivariable logistic regression models.</p></sec><sec><title>Results</title><p>The OR for pancreatic cancer was 1.10 [95% confidence interval (CI) 0.98–1.23] for history of ulcer (OR = 1.08 for gastric and 0.97 for duodenal ulcer). The association was stronger for a diagnosis within 2 years before cancer diagnosis (OR = 2.43 for peptic, 1.75 for gastric, and 1.98 for duodenal ulcer). The OR was 1.53 (95% CI 1.15–2.03) for history of gastrectomy; however, the excess risk was limited to a gastrectomy within 2 years before cancer diagnosis (OR = 6.18, 95% CI 1.82–20.96), while no significant increased risk was observed for longer time since gastrectomy. No associations were observed for pharmacological treatments for ulcer, such as antacids, H2-receptor antagonists, or proton-pump inhibitors.</p></sec><sec><title>Conclusions</title><p>This uniquely large collaborative study does not support the hypothesis that peptic ulcer and its treatment materially affect pancreatic cancer risk. The increased risk for short-term history of ulcer and gastrectomy suggests that any such association is due to increased cancer surveillance.</p></sec></abstract><kwd-group><kwd>anti-ulcer drugs</kwd><kwd>case–control study</kwd><kwd>gastrectomy</kwd><kwd>pancreatic cancer</kwd><kwd>peptic ulcer</kwd><kwd>pooled analysis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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