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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case–Control Consortium (PanC4)</title><author><name sortKey="Lucenteforte, E" sort="Lucenteforte, E" uniqKey="Lucenteforte E" first="E." last="Lucenteforte">E. Lucenteforte</name><affiliation><nlm:aff id="aff1">Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri” Milan</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Occupational Health, University of Milan, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C." last="La Vecchia">C. La Vecchia</name><affiliation><nlm:aff id="aff1">Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri” Milan</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Occupational Health, University of Milan, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Silverman, D" sort="Silverman, D" uniqKey="Silverman D" first="D." last="Silverman">D. Silverman</name><affiliation><nlm:aff id="aff3">National Cancer Institute, Bethesda</nlm:aff></affiliation></author><author><name sortKey="Petersen, G M" sort="Petersen, G M" uniqKey="Petersen G" first="G. M." last="Petersen">G. M. Petersen</name><affiliation><nlm:aff id="aff4">Mayo Clinic, Rochester</nlm:aff></affiliation></author><author><name sortKey="Bracci, P M" sort="Bracci, P M" uniqKey="Bracci P" first="P. M." last="Bracci">P. M. Bracci</name><affiliation><nlm:aff id="aff5">University of California – San Francisco, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Ji, B T" sort="Ji, B T" uniqKey="Ji B" first="B. T." last="Ji">B. T. Ji</name><affiliation><nlm:aff id="aff3">National Cancer Institute, Bethesda</nlm:aff></affiliation></author><author><name sortKey="Bosetti, C" sort="Bosetti, C" uniqKey="Bosetti C" first="C." last="Bosetti">C. Bosetti</name><affiliation><nlm:aff id="aff1">Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri” Milan</nlm:aff></affiliation></author><author><name sortKey="Li, D" sort="Li, D" uniqKey="Li D" first="D." last="Li">D. Li</name><affiliation><nlm:aff id="aff6">MD Anderson Cancer Center, Houston, USA</nlm:aff></affiliation></author><author><name sortKey="Gallinger, S" sort="Gallinger, S" uniqKey="Gallinger S" first="S." last="Gallinger">S. Gallinger</name><affiliation><nlm:aff id="aff7">Toronto General Hospital</nlm:aff></affiliation></author><author><name sortKey="Miller, A B" sort="Miller, A B" uniqKey="Miller A" first="A. B." last="Miller">A. B. Miller</name><affiliation><nlm:aff id="aff8">Dalla Lana School of Public Health, University of Toronto, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H. B." last="Bueno-De-Mesquita">H. B. Bueno-De-Mesquita</name><affiliation><nlm:aff id="aff9">National Institute for Public Health and the Environment (RIVM), Bilthoven</nlm:aff></affiliation><affiliation><nlm:aff id="aff10">Department of Gastroenterology and Hepatology, University Medical Center Utrecht (UMCU), Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Talamini, R" sort="Talamini, R" uniqKey="Talamini R" first="R." last="Talamini">R. Talamini</name><affiliation><nlm:aff id="aff11">Centro di Riferimento Oncologico (CRO) – National Cancer Institute, Aviano (PN), Italy</nlm:aff></affiliation></author><author><name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J." last="Polesel">J. Polesel</name><affiliation><nlm:aff id="aff11">Centro di Riferimento Oncologico (CRO) – National Cancer Institute, Aviano (PN), Italy</nlm:aff></affiliation></author><author><name sortKey="Ghadirian, P" sort="Ghadirian, P" uniqKey="Ghadirian P" first="P." last="Ghadirian">P. Ghadirian</name><affiliation><nlm:aff id="aff12">Epidemiology Research Unit, Research Center of the University of Montreal Hospital Centre (CRCHUM), Montreal, Canada</nlm:aff></affiliation></author><author><name sortKey="Baghurst, P A" sort="Baghurst, P A" uniqKey="Baghurst P" first="P. A." last="Baghurst">P. A. Baghurst</name><affiliation><nlm:aff id="aff13">Public Health, Women's and Children's Hospital, Adelaide, Australia</nlm:aff></affiliation></author><author><name sortKey="Zatonski, W" sort="Zatonski, W" uniqKey="Zatonski W" first="W." last="Zatonski">W. Zatonski</name><affiliation><nlm:aff id="aff14">Cancer Center & Institute of Oncology, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Fontham, E" sort="Fontham, E" uniqKey="Fontham E" first="E." last="Fontham">E. Fontham</name><affiliation><nlm:aff id="aff15">Louisiana State University, New Orleans, USA</nlm:aff></affiliation></author><author><name sortKey="Bamlet, W R" sort="Bamlet, W R" uniqKey="Bamlet W" first="W. R." last="Bamlet">W. R. Bamlet</name><affiliation><nlm:aff id="aff4">Mayo Clinic, Rochester</nlm:aff></affiliation></author><author><name sortKey="Holly, E A" sort="Holly, E A" uniqKey="Holly E" first="E. A." last="Holly">E. A. Holly</name><affiliation><nlm:aff id="aff5">University of California – San Francisco, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Gao, Y T" sort="Gao, Y T" uniqKey="Gao Y" first="Y. T." last="Gao">Y. T. Gao</name><affiliation><nlm:aff id="aff16">Shanghai Cancer Institute, Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E." last="Negri">E. Negri</name><affiliation><nlm:aff id="aff1">Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri” Milan</nlm:aff></affiliation></author><author><name sortKey="Hassan, M" sort="Hassan, M" uniqKey="Hassan M" first="M." last="Hassan">M. Hassan</name><affiliation><nlm:aff id="aff6">MD Anderson Cancer Center, Houston, USA</nlm:aff></affiliation></author><author><name sortKey="Cotterchio, M" sort="Cotterchio, M" uniqKey="Cotterchio M" first="M." last="Cotterchio">M. Cotterchio</name><affiliation><nlm:aff id="aff8">Dalla Lana School of Public Health, University of Toronto, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="aff17">Population Studies and Surveillance, Cancer Care Ontario, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Su, J" sort="Su, J" uniqKey="Su J" first="J." last="Su">J. Su</name><affiliation><nlm:aff id="aff3">National Cancer Institute, Bethesda</nlm:aff></affiliation></author><author><name sortKey="Maisonneuve, P" sort="Maisonneuve, P" uniqKey="Maisonneuve P" first="P." last="Maisonneuve">P. Maisonneuve</name><affiliation><nlm:aff id="aff18">European Institute of Oncology, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name><affiliation><nlm:aff id="aff19">International Prevention Research Institute, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff20">The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Duell, E J" sort="Duell, E J" uniqKey="Duell E" first="E. J." last="Duell">E. J. Duell</name><affiliation><nlm:aff id="aff21">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff22">Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21536662</idno><idno type="pmc">3265544</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265544</idno><idno type="RBID">PMC:3265544</idno><idno type="doi">10.1093/annonc/mdr120</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001734</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001734</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case–Control Consortium (PanC4)</title><author><name sortKey="Lucenteforte, E" sort="Lucenteforte, E" uniqKey="Lucenteforte E" first="E." last="Lucenteforte">E. Lucenteforte</name><affiliation><nlm:aff id="aff1">Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri” Milan</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Occupational Health, University of Milan, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C." last="La Vecchia">C. La Vecchia</name><affiliation><nlm:aff id="aff1">Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri” Milan</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Occupational Health, University of Milan, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Silverman, D" sort="Silverman, D" uniqKey="Silverman D" first="D." last="Silverman">D. Silverman</name><affiliation><nlm:aff id="aff3">National Cancer Institute, Bethesda</nlm:aff></affiliation></author><author><name sortKey="Petersen, G M" sort="Petersen, G M" uniqKey="Petersen G" first="G. M." last="Petersen">G. M. Petersen</name><affiliation><nlm:aff id="aff4">Mayo Clinic, Rochester</nlm:aff></affiliation></author><author><name sortKey="Bracci, P M" sort="Bracci, P M" uniqKey="Bracci P" first="P. M." last="Bracci">P. M. Bracci</name><affiliation><nlm:aff id="aff5">University of California – San Francisco, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Ji, B T" sort="Ji, B T" uniqKey="Ji B" first="B. T." last="Ji">B. T. Ji</name><affiliation><nlm:aff id="aff3">National Cancer Institute, Bethesda</nlm:aff></affiliation></author><author><name sortKey="Bosetti, C" sort="Bosetti, C" uniqKey="Bosetti C" first="C." last="Bosetti">C. Bosetti</name><affiliation><nlm:aff id="aff1">Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri” Milan</nlm:aff></affiliation></author><author><name sortKey="Li, D" sort="Li, D" uniqKey="Li D" first="D." last="Li">D. Li</name><affiliation><nlm:aff id="aff6">MD Anderson Cancer Center, Houston, USA</nlm:aff></affiliation></author><author><name sortKey="Gallinger, S" sort="Gallinger, S" uniqKey="Gallinger S" first="S." last="Gallinger">S. Gallinger</name><affiliation><nlm:aff id="aff7">Toronto General Hospital</nlm:aff></affiliation></author><author><name sortKey="Miller, A B" sort="Miller, A B" uniqKey="Miller A" first="A. B." last="Miller">A. B. Miller</name><affiliation><nlm:aff id="aff8">Dalla Lana School of Public Health, University of Toronto, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H. B." last="Bueno-De-Mesquita">H. B. Bueno-De-Mesquita</name><affiliation><nlm:aff id="aff9">National Institute for Public Health and the Environment (RIVM), Bilthoven</nlm:aff></affiliation><affiliation><nlm:aff id="aff10">Department of Gastroenterology and Hepatology, University Medical Center Utrecht (UMCU), Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Talamini, R" sort="Talamini, R" uniqKey="Talamini R" first="R." last="Talamini">R. Talamini</name><affiliation><nlm:aff id="aff11">Centro di Riferimento Oncologico (CRO) – National Cancer Institute, Aviano (PN), Italy</nlm:aff></affiliation></author><author><name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J." last="Polesel">J. Polesel</name><affiliation><nlm:aff id="aff11">Centro di Riferimento Oncologico (CRO) – National Cancer Institute, Aviano (PN), Italy</nlm:aff></affiliation></author><author><name sortKey="Ghadirian, P" sort="Ghadirian, P" uniqKey="Ghadirian P" first="P." last="Ghadirian">P. Ghadirian</name><affiliation><nlm:aff id="aff12">Epidemiology Research Unit, Research Center of the University of Montreal Hospital Centre (CRCHUM), Montreal, Canada</nlm:aff></affiliation></author><author><name sortKey="Baghurst, P A" sort="Baghurst, P A" uniqKey="Baghurst P" first="P. A." last="Baghurst">P. A. Baghurst</name><affiliation><nlm:aff id="aff13">Public Health, Women's and Children's Hospital, Adelaide, Australia</nlm:aff></affiliation></author><author><name sortKey="Zatonski, W" sort="Zatonski, W" uniqKey="Zatonski W" first="W." last="Zatonski">W. Zatonski</name><affiliation><nlm:aff id="aff14">Cancer Center & Institute of Oncology, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Fontham, E" sort="Fontham, E" uniqKey="Fontham E" first="E." last="Fontham">E. Fontham</name><affiliation><nlm:aff id="aff15">Louisiana State University, New Orleans, USA</nlm:aff></affiliation></author><author><name sortKey="Bamlet, W R" sort="Bamlet, W R" uniqKey="Bamlet W" first="W. R." last="Bamlet">W. R. Bamlet</name><affiliation><nlm:aff id="aff4">Mayo Clinic, Rochester</nlm:aff></affiliation></author><author><name sortKey="Holly, E A" sort="Holly, E A" uniqKey="Holly E" first="E. A." last="Holly">E. A. Holly</name><affiliation><nlm:aff id="aff5">University of California – San Francisco, San Francisco</nlm:aff></affiliation></author><author><name sortKey="Gao, Y T" sort="Gao, Y T" uniqKey="Gao Y" first="Y. T." last="Gao">Y. T. Gao</name><affiliation><nlm:aff id="aff16">Shanghai Cancer Institute, Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E." last="Negri">E. Negri</name><affiliation><nlm:aff id="aff1">Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri” Milan</nlm:aff></affiliation></author><author><name sortKey="Hassan, M" sort="Hassan, M" uniqKey="Hassan M" first="M." last="Hassan">M. Hassan</name><affiliation><nlm:aff id="aff6">MD Anderson Cancer Center, Houston, USA</nlm:aff></affiliation></author><author><name sortKey="Cotterchio, M" sort="Cotterchio, M" uniqKey="Cotterchio M" first="M." last="Cotterchio">M. Cotterchio</name><affiliation><nlm:aff id="aff8">Dalla Lana School of Public Health, University of Toronto, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="aff17">Population Studies and Surveillance, Cancer Care Ontario, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Su, J" sort="Su, J" uniqKey="Su J" first="J." last="Su">J. Su</name><affiliation><nlm:aff id="aff3">National Cancer Institute, Bethesda</nlm:aff></affiliation></author><author><name sortKey="Maisonneuve, P" sort="Maisonneuve, P" uniqKey="Maisonneuve P" first="P." last="Maisonneuve">P. Maisonneuve</name><affiliation><nlm:aff id="aff18">European Institute of Oncology, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name><affiliation><nlm:aff id="aff19">International Prevention Research Institute, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff20">The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Duell, E J" sort="Duell, E J" uniqKey="Duell E" first="E. J." last="Duell">E. J. Duell</name><affiliation><nlm:aff id="aff21">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff22">Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</nlm:aff></affiliation></author></analytic><series><title level="j">Annals of Oncology</title><idno type="ISSN">0923-7534</idno><idno type="eISSN">1569-8041</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Heavy alcohol drinking has been related to pancreatic cancer, but the issue is still unsolved.</p></sec><sec><title>Methods:</title><p>To evaluate the role of alcohol consumption in relation to pancreatic cancer, we conducted a pooled analysis of 10 case–control studies (5585 cases and 11 827 controls) participating in the International Pancreatic Cancer Case–Control Consortium. We computed pooled odds ratios (ORs) by estimating study-specific ORs adjusted for selected covariates and pooling them using random effects models.</p></sec><sec><title>Results:</title><p>Compared with abstainers and occasional drinkers (<1 drink per day), we observed no association for light-to-moderate alcohol consumption (≤4 drinks per day) and pancreatic cancer risk; however, associations were above unity for higher consumption levels (OR = 1.6, 95% confidence interval 1.2–2.2 for subjects drinking ≥9 drinks per day). Results did not change substantially when we evaluated associations by tobacco smoking status, or when we excluded participants who reported a history of pancreatitis, or participants whose data were based upon proxy responses. Further, no notable differences in pooled risk estimates emerged across strata of sex, age, race, study type, and study area.</p></sec><sec><title>Conclusion:</title><p>This collaborative-pooled analysis provides additional evidence for a positive association between heavy alcohol consumption and the risk of pancreatic cancer.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Ann Oncol</journal-id><journal-id journal-id-type="hwp">annonc</journal-id><journal-id journal-id-type="publisher-id">annonc</journal-id><journal-title-group><journal-title>Annals of Oncology</journal-title></journal-title-group><issn pub-type="ppub">0923-7534</issn><issn pub-type="epub">1569-8041</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21536662</article-id><article-id pub-id-type="pmc">3265544</article-id><article-id pub-id-type="doi">10.1093/annonc/mdr120</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject><subj-group><subject>Gastrointestinal Tumors</subject></subj-group></subj-group></article-categories><title-group><article-title>Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case–Control Consortium (PanC4)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lucenteforte</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>La Vecchia</surname><given-names>C.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Silverman</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Petersen</surname><given-names>G. M.</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Bracci</surname><given-names>P. M.</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Ji</surname><given-names>B. T.</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Bosetti</surname><given-names>C.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Gallinger</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Miller</surname><given-names>A. B.</given-names></name><xref ref-type="aff" rid="aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>Bueno-de-Mesquita</surname><given-names>H. B.</given-names></name><xref ref-type="aff" rid="aff9">9</xref><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Talamini</surname><given-names>R.</given-names></name><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Polesel</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Ghadirian</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="aff12">12</xref></contrib><contrib contrib-type="author"><name><surname>Baghurst</surname><given-names>P. A.</given-names></name><xref ref-type="aff" rid="aff13">13</xref></contrib><contrib contrib-type="author"><name><surname>Zatonski</surname><given-names>W.</given-names></name><xref ref-type="aff" rid="aff14">14</xref></contrib><contrib contrib-type="author"><name><surname>Fontham</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="aff15">15</xref></contrib><contrib contrib-type="author"><name><surname>Bamlet</surname><given-names>W. R.</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Holly</surname><given-names>E. A.</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Y. T.</given-names></name><xref ref-type="aff" rid="aff16">16</xref></contrib><contrib contrib-type="author"><name><surname>Negri</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hassan</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Cotterchio</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="aff8">8</xref><xref ref-type="aff" rid="aff17">17</xref></contrib><contrib contrib-type="author"><name><surname>Su</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Maisonneuve</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="aff18">18</xref></contrib><contrib contrib-type="author"><name><surname>Boffetta</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="aff19">19</xref><xref ref-type="aff" rid="aff20">20</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Duell</surname><given-names>E. J.</given-names></name><xref ref-type="aff" rid="aff21">21</xref><xref ref-type="aff" rid="aff22">22</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri” Milan</aff><aff id="aff2"><label>2</label>Department of Occupational Health, University of Milan, Milan, Italy</aff><aff id="aff3"><label>3</label>National Cancer Institute, Bethesda</aff><aff id="aff4"><label>4</label>Mayo Clinic, Rochester</aff><aff id="aff5"><label>5</label>University of California – San Francisco, San Francisco</aff><aff id="aff6"><label>6</label>MD Anderson Cancer Center, Houston, USA</aff><aff id="aff7"><label>7</label>Toronto General Hospital</aff><aff id="aff8"><label>8</label>Dalla Lana School of Public Health, University of Toronto, Toronto, Canada</aff><aff id="aff9"><label>9</label>National Institute for Public Health and the Environment (RIVM), Bilthoven</aff><aff id="aff10"><label>10</label>Department of Gastroenterology and Hepatology, University Medical Center Utrecht (UMCU), Utrecht, The Netherlands</aff><aff id="aff11"><label>11</label>Centro di Riferimento Oncologico (CRO) – National Cancer Institute, Aviano (PN), Italy</aff><aff id="aff12"><label>12</label>Epidemiology Research Unit, Research Center of the University of Montreal Hospital Centre (CRCHUM), Montreal, Canada</aff><aff id="aff13"><label>13</label>Public Health, Women's and Children's Hospital, Adelaide, Australia</aff><aff id="aff14"><label>14</label>Cancer Center & Institute of Oncology, Warsaw, Poland</aff><aff id="aff15"><label>15</label>Louisiana State University, New Orleans, USA</aff><aff id="aff16"><label>16</label>Shanghai Cancer Institute, Shanghai, China</aff><aff id="aff17"><label>17</label>Population Studies and Surveillance, Cancer Care Ontario, Toronto, Canada</aff><aff id="aff18"><label>18</label>European Institute of Oncology, Milan, Italy</aff><aff id="aff19"><label>19</label>International Prevention Research Institute, Lyon, France</aff><aff id="aff20"><label>20</label>The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, USA</aff><aff id="aff21"><label>21</label>International Agency for Research on Cancer, Lyon, France</aff><aff id="aff22"><label>22</label>Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</aff><author-notes><corresp id="cor1"><label>*</label><italic>Correspondence to:</italic> Dr P. Boffetta, The Tisch Cancer Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA. Tel: +1-212-8247073; Fax: +1-212-9960407; E-mail: <email>paolo.boffetta@exchange.mssm.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>2</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>2</day><month>5</month><year>2011</year></pub-date><volume>23</volume><issue>2</issue><fpage>374</fpage><lpage>382</lpage><history><date date-type="received"><day>10</day><month>6</month><year>2011</year></date><date date-type="rev-recd"><day>25</day><month>2</month><year>2011</year></date><date date-type="accepted"><day>28</day><month>2</month><year>2011</year></date></history><permissions><copyright-statement>© The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><sec><title>Background:</title><p>Heavy alcohol drinking has been related to pancreatic cancer, but the issue is still unsolved.</p></sec><sec><title>Methods:</title><p>To evaluate the role of alcohol consumption in relation to pancreatic cancer, we conducted a pooled analysis of 10 case–control studies (5585 cases and 11 827 controls) participating in the International Pancreatic Cancer Case–Control Consortium. We computed pooled odds ratios (ORs) by estimating study-specific ORs adjusted for selected covariates and pooling them using random effects models.</p></sec><sec><title>Results:</title><p>Compared with abstainers and occasional drinkers (<1 drink per day), we observed no association for light-to-moderate alcohol consumption (≤4 drinks per day) and pancreatic cancer risk; however, associations were above unity for higher consumption levels (OR = 1.6, 95% confidence interval 1.2–2.2 for subjects drinking ≥9 drinks per day). Results did not change substantially when we evaluated associations by tobacco smoking status, or when we excluded participants who reported a history of pancreatitis, or participants whose data were based upon proxy responses. Further, no notable differences in pooled risk estimates emerged across strata of sex, age, race, study type, and study area.</p></sec><sec><title>Conclusion:</title><p>This collaborative-pooled analysis provides additional evidence for a positive association between heavy alcohol consumption and the risk of pancreatic cancer.</p></sec></abstract><kwd-group><kwd>alcohol drinking</kwd><kwd>case–control studies</kwd><kwd>ethanol</kwd><kwd>pancreatic cancer</kwd><kwd>pooled analysis</kwd><kwd>risk factors</kwd></kwd-group><counts><page-count count="9"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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