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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating <italic>MAP3K1</italic></title><author><name sortKey="Glubb, Dylan M" sort="Glubb, Dylan M" uniqKey="Glubb D" first="Dylan M." last="Glubb">Dylan M. Glubb</name><affiliation><nlm:aff id="aff1">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Maranian, Mel J" sort="Maranian, Mel J" uniqKey="Maranian M" first="Mel J." last="Maranian">Mel J. Maranian</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Meyer, Kerstin B" sort="Meyer, Kerstin B" uniqKey="Meyer K" first="Kerstin B." last="Meyer">Kerstin B. Meyer</name><affiliation><nlm:aff id="aff4">Cancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Kar, Siddhartha" sort="Kar, Siddhartha" uniqKey="Kar S" first="Siddhartha" last="Kar">Siddhartha Kar</name><affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Carlebur, Saskia" sort="Carlebur, Saskia" uniqKey="Carlebur S" first="Saskia" last="Carlebur">Saskia Carlebur</name><affiliation><nlm:aff id="aff4">Cancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Martin" sort="O Eilly, Martin" uniqKey="O Eilly M" first="Martin" last="O Eilly">Martin O Eilly</name><affiliation><nlm:aff id="aff4">Cancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Betts, Joshua A" sort="Betts, Joshua A" uniqKey="Betts J" first="Joshua A." last="Betts">Joshua A. Betts</name><affiliation><nlm:aff id="aff1">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia</nlm:aff></affiliation></author><author><name sortKey="Hillman, Kristine M" sort="Hillman, Kristine M" uniqKey="Hillman K" first="Kristine M." last="Hillman">Kristine M. Hillman</name><affiliation><nlm:aff id="aff1">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Kaufmann, Susanne" sort="Kaufmann, Susanne" uniqKey="Kaufmann S" first="Susanne" last="Kaufmann">Susanne Kaufmann</name><affiliation><nlm:aff id="aff1">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="aff1">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Canisius, Sander" sort="Canisius, Sander" uniqKey="Canisius S" first="Sander" last="Canisius">Sander Canisius</name><affiliation><nlm:aff id="aff6">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="aff7">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="aff8">Department of Pathology, University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation><nlm:aff id="aff8">Department of Pathology, University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="aff8">Department of Pathology, University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="aff6">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="aff6">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans B" sort="Hogervorst, Frans B" uniqKey="Hogervorst F" first="Frans B." last="Hogervorst">Frans B. Hogervorst</name><affiliation><nlm:aff id="aff6">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Schoot, C Ellen" sort="Van Der Schoot, C Ellen" uniqKey="Van Der Schoot C" first="C. Ellen" last="Van Der Schoot">C. Ellen Van Der Schoot</name><affiliation><nlm:aff id="aff9">Sanquin Research, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="aff10">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff11">Institute of Population Health, University of Manchester, Manchester M13 9PL, UK</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="aff10">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK</nlm:aff></affiliation></author><author><name sortKey="Stewart Brown, Sarah" sort="Stewart Brown, Sarah" uniqKey="Stewart Brown S" first="Sarah" last="Stewart-Brown">Sarah Stewart-Brown</name><affiliation><nlm:aff id="aff10">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK</nlm:aff></affiliation></author><author><name sortKey="Siriwanarangsan, Pornthep" sort="Siriwanarangsan, Pornthep" uniqKey="Siriwanarangsan P" first="Pornthep" last="Siriwanarangsan">Pornthep Siriwanarangsan</name><affiliation><nlm:aff id="aff12">Ministry of Public Health, Nonthaburi 11000, Thailand</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="aff13">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA</nlm:aff></affiliation></author><author><name sortKey="Ruebner, Matthias" sort="Ruebner, Matthias" uniqKey="Ruebner M" first="Matthias" last="Ruebner">Matthias Ruebner</name><affiliation><nlm:aff id="aff13">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="aff15">Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="aff13">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="aff16">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:aff id="aff16">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="aff17">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="aff17">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="aff18">Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London SE1 9RT, UK</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="aff19">Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name><affiliation><nlm:aff id="aff20">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="aff20">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="aff21">Department of Obstetrics and Gynecology, University of Heidelberg, 69115 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="aff21">Department of Obstetrics and Gynecology, University of Heidelberg, 69115 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff22">National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Yang, Rongxi" sort="Yang, Rongxi" uniqKey="Yang R" first="Rongxi" last="Yang">Rongxi Yang</name><affiliation><nlm:aff id="aff21">Department of Obstetrics and Gynecology, University of Heidelberg, 69115 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff23">Molecular Genetics of Breast Cancer, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Surowy, Harald" sort="Surowy, Harald" uniqKey="Surowy H" first="Harald" last="Surowy">Harald Surowy</name><affiliation><nlm:aff id="aff21">Department of Obstetrics and Gynecology, University of Heidelberg, 69115 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff23">Molecular Genetics of Breast Cancer, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="aff24">Institut National de la Santé et de la Recherche Médicale U1018, Environmental Epidemiology of Cancers, Centre de Recherche en Epidémiologie et Santé des Populations, 94807 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff25">UMRS 1018, University Paris-Sud, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="aff24">Institut National de la Santé et de la Recherche Médicale U1018, Environmental Epidemiology of Cancers, Centre de Recherche en Epidémiologie et Santé des Populations, 94807 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff25">UMRS 1018, University Paris-Sud, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation><nlm:aff id="aff24">Institut National de la Santé et de la Recherche Médicale U1018, Environmental Epidemiology of Cancers, Centre de Recherche en Epidémiologie et Santé des Populations, 94807 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff25">UMRS 1018, University Paris-Sud, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Sanchez, Marie" sort="Sanchez, Marie" uniqKey="Sanchez M" first="Marie" last="Sanchez">Marie Sanchez</name><affiliation><nlm:aff id="aff24">Institut National de la Santé et de la Recherche Médicale U1018, Environmental Epidemiology of Cancers, Centre de Recherche en Epidémiologie et Santé des Populations, 94807 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff25">UMRS 1018, University Paris-Sud, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="aff26">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="aff27">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="aff28">Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="aff26">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="aff27">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="aff28">Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="aff26">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="aff27">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="aff29">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation><nlm:aff id="aff30">Centro Nacional de Genotipado Human Genotyping Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="aff31">Centro de Investigación en Red de Enfermedades Raras, 46010 Valencia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="aff32">Human Genetics Group, Spanish National Cancer Centre and Biomedical Network on Rare Diseases, 28029 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="aff33">Servicio de Oncología Médica, Hospital Universitario La Paz, 28029 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Perez">Jose Ignacio Arias Perez</name><affiliation><nlm:aff id="aff34">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, 33012 Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="aff35">Department of Epidemiology, University of California, Irvine, Irvine, CA 92697, USA</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="aff36">Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="aff37">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff38">German Cancer Consortium, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation><nlm:aff id="aff37">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff38">German Cancer Consortium, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="aff37">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="aff39">Saarland Cancer Registry, 66024 Saarbrücken, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="aff40">Division of Gynaecology and Obstetrics, Technische Universität München, 81675 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="aff41">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, 50931 Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff42">Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology, Center for Molecular Medicine Cologne, University Hospital of Cologne, 50937 Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff43">Center for Molecular Medicine Cologne, University of Cologne, 50923 Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff44">Center for Integrated Oncology, Medical Faculty, University Hospital of Cologne, 50937 Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="aff45">University of Tübingen, 72074 Tübingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff46">Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, 70376 Stuttgart, Germany</nlm:aff></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation><nlm:aff id="aff47">Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, 53113 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="aff48">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, 44789 Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="aff50">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, 00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="aff50">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, 00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="aff51">Department of Clinical Genetics, Helsinki University Central Hospital, 00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="aff52">Department of Oncology, University of Helsinki and Helsinki University Central Hospital, 00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:aff id="aff53">Department of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan</nlm:aff></affiliation></author><author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name><affiliation><nlm:aff id="aff54">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan</nlm:aff></affiliation></author><author><name sortKey="Iwata, Hiroji" sort="Iwata, Hiroji" uniqKey="Iwata H" first="Hiroji" last="Iwata">Hiroji Iwata</name><affiliation><nlm:aff id="aff55">Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Hideo" sort="Tanaka, Hideo" uniqKey="Tanaka H" first="Hideo" last="Tanaka">Hideo Tanaka</name><affiliation><nlm:aff id="aff54">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="aff56">Gynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="aff57">Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Helbig, Sonja" sort="Helbig, Sonja" uniqKey="Helbig S" first="Sonja" last="Helbig">Sonja Helbig</name><affiliation><nlm:aff id="aff56">Gynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="aff58">Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="aff59">Department of Oncology-Pathology, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="aff60">Cancer Center of Eastern Finland, University of Eastern Finland, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff61">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff62">School of Medicine, Institute of Clinical Medicine, Pathology, and Forensic Medicine, University of Eastern Finland, 70211 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="aff60">Cancer Center of Eastern Finland, University of Eastern Finland, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff61">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff62">School of Medicine, Institute of Clinical Medicine, Pathology, and Forensic Medicine, University of Eastern Finland, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff63">Cancer Center, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="aff60">Cancer Center of Eastern Finland, University of Eastern Finland, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff61">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff62">School of Medicine, Institute of Clinical Medicine, Pathology, and Forensic Medicine, University of Eastern Finland, 70211 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="aff60">Cancer Center of Eastern Finland, University of Eastern Finland, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff61">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff62">School of Medicine, Institute of Clinical Medicine, Pathology, and Forensic Medicine, University of Eastern Finland, 70211 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H." last="Wu">Anna H. Wu</name><affiliation><nlm:aff id="aff65">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name><affiliation><nlm:aff id="aff65">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, David" sort="Van Den Berg, David" uniqKey="Van Den Berg D" first="David" last="Van Den Berg">David Van Den Berg</name><affiliation><nlm:aff id="aff65">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name><affiliation><nlm:aff id="aff65">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="aff66">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, 3000 Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="aff67">Vesalius Research Center, VIB, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Zhao, Hui" sort="Zhao, Hui" uniqKey="Zhao H" first="Hui" last="Zhao">Hui Zhao</name><affiliation><nlm:aff id="aff66">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, 3000 Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="aff67">Vesalius Research Center, VIB, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Weltens, Caroline" sort="Weltens, Caroline" uniqKey="Weltens C" first="Caroline" last="Weltens">Caroline Weltens</name><affiliation><nlm:aff id="aff68">University Hospital Gashuisberg, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Van Limbergen, Erik" sort="Van Limbergen, Erik" uniqKey="Van Limbergen E" first="Erik" last="Van Limbergen">Erik Van Limbergen</name><affiliation><nlm:aff id="aff68">University Hospital Gashuisberg, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="aff69">Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="aff70">Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, 20246 Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="aff69">Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Seibold, Petra" sort="Seibold, Petra" uniqKey="Seibold P" first="Petra" last="Seibold">Petra Seibold</name><affiliation><nlm:aff id="aff69">Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="aff71">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Istituto Nazionale Tumori, Fondazione Istituto Neurologico Carlo Besta, 20133 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="aff72">Istituto Fondazione Italiana per la Ricerca sul Cancro di Oncologia Molecolare, 20139 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><affiliation><nlm:aff id="aff73">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, 20141 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Capra, Fabio" sort="Capra, Fabio" uniqKey="Capra F" first="Fabio" last="Capra">Fabio Capra</name><affiliation><nlm:aff id="aff72">Istituto Fondazione Italiana per la Ricerca sul Cancro di Oncologia Molecolare, 20139 Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="aff74">Cogentech Cancer Genetic Test Laboratory, 20139 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="aff75">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="aff76">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Hallberg, Emily" sort="Hallberg, Emily" uniqKey="Hallberg E" first="Emily" last="Hallberg">Emily Hallberg</name><affiliation><nlm:aff id="aff76">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="aff76">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="aff6">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="aff77">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="aff6">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="aff77">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="aff78">Anatomical Pathology, The Alfred, Melbourne, VIC 3004, Australia</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="aff65">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="aff65">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation><nlm:aff id="aff65">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="aff79">University of Hawaii Cancer Centre Honolulu, HI 96813, USA</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="aff80">Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, QC G1V 4G2, Canada</nlm:aff></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name><affiliation><nlm:aff id="aff81">Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC H3A 1A1, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="aff82">Department of Medicine, McGill University, Montreal, QC H3A 1A1, Canada</nlm:aff></affiliation></author><author><name sortKey="Labreche, France" sort="Labreche, France" uniqKey="Labreche F" first="France" last="Labrèche">France Labrèche</name><affiliation><nlm:aff id="aff83">Département de Médecine Sociale et Préventive, Département de Santé Environnementale et Santé au Travail, Université de Montréal, Montreal, QC H3A 3C2, Canada</nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="aff80">Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, QC G1V 4G2, Canada</nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo Hwang" last="Teo">Soo Hwang Teo</name><affiliation><nlm:aff id="aff84">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 47500 Subang Jaya, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="aff85">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng Har" last="Yip">Cheng Har Yip</name><affiliation><nlm:aff id="aff85">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="See, Mee Hoong" sort="See, Mee Hoong" uniqKey="See M" first="Mee-Hoong" last="See">Mee-Hoong See</name><affiliation><nlm:aff id="aff85">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Cornes, Belinda" sort="Cornes, Belinda" uniqKey="Cornes B" first="Belinda" last="Cornes">Belinda Cornes</name><affiliation><nlm:aff id="aff86">Singapore Eye Research Institute, National University of Singapore, Singapore 168751, Singapore</nlm:aff></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name><affiliation><nlm:aff id="aff86">Singapore Eye Research Institute, National University of Singapore, Singapore 168751, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ikram, M Kamran" sort="Ikram, M Kamran" uniqKey="Ikram M" first="M. Kamran" last="Ikram">M. Kamran Ikram</name><affiliation><nlm:aff id="aff86">Singapore Eye Research Institute, National University of Singapore, Singapore 168751, Singapore</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="aff87">Institute of Clinical Medicine, University of Oslo, 0450 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="aff88">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="aff89">Department of Clinical Molecular Biology, University of Oslo, 0450 Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Halverson, Sandra L" sort="Halverson, Sandra L" uniqKey="Halverson S" first="Sandra L." last="Halverson">Sandra L. Halverson</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Martha" sort="Shrubsole, Martha" uniqKey="Shrubsole M" first="Martha" last="Shrubsole">Martha Shrubsole</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="aff103">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu, Oulu University Hospital, 90210 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="aff103">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu, Oulu University Hospital, 90210 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="aff104">Department of Oncology, Oulu University Hospital, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kauppila, Saila" sort="Kauppila, Saila" uniqKey="Kauppila S" first="Saila" last="Kauppila">Saila Kauppila</name><affiliation><nlm:aff id="aff105">Department of Pathology, Oulu University Hospital, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="aff106">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="aff107">Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="aff108">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="aff109">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="aff110">Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name><affiliation><nlm:aff id="aff110">Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="aff111">Departments of Human Genetics and Pathology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="aff111">Departments of Human Genetics and Pathology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="aff112">Family Cancer Clinic, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J." last="Van Asperen">Christi J. Van Asperen</name><affiliation><nlm:aff id="aff113">Department of Clinical Genetics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="aff17">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff114">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="aff115">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="aff115">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="aff116">Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="aff117">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Klevebring, Daniel" sort="Klevebring, Daniel" uniqKey="Klevebring D" first="Daniel" last="Klevebring">Daniel Klevebring</name><affiliation><nlm:aff id="aff117">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="aff117">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name><affiliation><nlm:aff id="aff117">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="aff118">Department of Medical Oncology, Erasmus University Medical Center Cancer Institute, 3075 EA Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="aff118">Department of Medical Oncology, Erasmus University Medical Center Cancer Institute, 3075 EA Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation><nlm:aff id="aff118">Department of Medical Oncology, Erasmus University Medical Center Cancer Institute, 3075 EA Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J. Margriet" last="Collée">J. Margriet Collée</name><affiliation><nlm:aff id="aff119">Department of Clinical Genetics, Erasmus University Medical Center, 3008 AE Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="aff117">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="aff120">Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="aff117">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Lu, Wei" sort="Lu, Wei" uniqKey="Lu W" first="Wei" last="Lu">Wei Lu</name><affiliation><nlm:aff id="aff121">Shanghai Center for Disease Control and Prevention, Changning, Shanghai 200336, China</nlm:aff></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation><nlm:aff id="aff122">Department of Epidemiology, Shanghai Cancer Institute, Shanghai 200032, China</nlm:aff></affiliation></author><author><name sortKey="Cai, Hui" sort="Cai, Hui" uniqKey="Cai H" first="Hui" last="Cai">Hui Cai</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="aff123">Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="aff124">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2RX, UK</nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="aff123">Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK</nlm:aff></affiliation></author><author><name sortKey="Blot, William" sort="Blot, William" uniqKey="Blot W" first="William" last="Blot">William Blot</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation><affiliation><nlm:aff id="aff125">International Epidemiology Institute, Rockville, MD 20850, USA</nlm:aff></affiliation></author><author><name sortKey="Signorello, Lisa B" sort="Signorello, Lisa B" uniqKey="Signorello L" first="Lisa B." last="Signorello">Lisa B. Signorello</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation><affiliation><nlm:aff id="aff125">International Epidemiology Institute, Rockville, MD 20850, USA</nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="aff126">Department of Preventive Medicine, Seoul National University College of Medicine and Cancer Research Institute, Seoul National University, Seoul 110-799, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="aff127">Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 151-742, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="aff128">Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation></author><author><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name><affiliation><nlm:aff id="aff127">Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 151-742, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="aff128">Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation></author><author><name sortKey="Park, Sue K" sort="Park, Sue K" uniqKey="Park S" first="Sue K." last="Park">Sue K. Park</name><affiliation><nlm:aff id="aff126">Department of Preventive Medicine, Seoul National University College of Medicine and Cancer Research Institute, Seoul National University, Seoul 110-799, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="aff127">Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 151-742, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="aff128">Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation></author><author><name sortKey="Noh, Dong Young" sort="Noh, Dong Young" uniqKey="Noh D" first="Dong-Young" last="Noh">Dong-Young Noh</name><affiliation><nlm:aff id="aff129">Department of Surgery, Seoul National University, Bundang Hospital, Seongnam 110-744, Korea</nlm:aff></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation><nlm:aff id="aff130">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="aff131">Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore 119228, Singapore</nlm:aff></affiliation></author><author><name sortKey="Miao, Hui" sort="Miao, Hui" uniqKey="Miao H" first="Hui" last="Miao">Hui Miao</name><affiliation><nlm:aff id="aff130">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore</nlm:aff></affiliation></author><author><name sortKey="Lim, Wei Yen" sort="Lim, Wei Yen" uniqKey="Lim W" first="Wei Yen" last="Lim">Wei Yen Lim</name><affiliation><nlm:aff id="aff130">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore</nlm:aff></affiliation></author><author><name sortKey="Tang, Anthony" sort="Tang, Anthony" uniqKey="Tang A" first="Anthony" last="Tang">Anthony Tang</name><affiliation><nlm:aff id="aff132">Division of General Surgery, National University Health System, Singapore 119228, Singapore</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="aff23">Molecular Genetics of Breast Cancer, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation><nlm:aff id="aff23">Molecular Genetics of Breast Cancer, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff133">Institute of Human Genetics, Pontificia Universidad Javeriana, Bogotá 11001000, Colombia</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="aff134">Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="aff134">Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="aff134">Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="aff134">Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="aff135">National Cancer Institute, Bangkok 10400, Thailand</nlm:aff></affiliation></author><author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name><affiliation><nlm:aff id="aff136">International Agency for Research on Cancer, 69372 Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="aff136">International Agency for Research on Cancer, 69372 Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name><affiliation><nlm:aff id="aff136">International Agency for Research on Cancer, 69372 Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Olswold, Curtis" sort="Olswold, Curtis" uniqKey="Olswold C" first="Curtis" last="Olswold">Curtis Olswold</name><affiliation><nlm:aff id="aff76">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation><nlm:aff id="aff76">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="aff137">Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA</nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation><nlm:aff id="aff138">Molecular Diagnostics Laboratory, Institute of Radioisotopes and Radiodiagnostic Products, National Centre for Scientific Research “Demokritos,” Aghia Paraskevi Attikis, Athens 15310, Greece</nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="aff139">Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="aff140">School of Public Health, China Medical University, Taichung 40402, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="aff141">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Wu, Pei Ei" sort="Wu, Pei Ei" uniqKey="Wu P" first="Pei-Ei" last="Wu">Pei-Ei Wu</name><affiliation><nlm:aff id="aff139">Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="aff141">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Yu, Jyh Cherng" sort="Yu, Jyh Cherng" uniqKey="Yu J" first="Jyh-Cherng" last="Yu">Jyh-Cherng Yu</name><affiliation><nlm:aff id="aff142">Department of Surgery, Tri-Service General Hospital, Taipei 114, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hou, Ming Feng" sort="Hou, Ming Feng" uniqKey="Hou M" first="Ming-Feng" last="Hou">Ming-Feng Hou</name><affiliation><nlm:aff id="aff143">Cancer Center and Department of Surgery, Kaohsiung Medical University, Chung-Ho Memorial Hospital, Kaohsiung 807, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="aff114">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff144">Division of Breast Cancer Research, Institute of Cancer Research, Sutton SM2 5NG, UK</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="aff17">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="aff17">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation><nlm:aff id="aff114">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK</nlm:aff></affiliation></author><author><name sortKey="Pita, Guillermo" sort="Pita, Guillermo" uniqKey="Pita G" first="Guillermo" last="Pita">Guillermo Pita</name><affiliation><nlm:aff id="aff30">Centro Nacional de Genotipado Human Genotyping Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Alonso, M Rosario" sort="Alonso, M Rosario" uniqKey="Alonso M" first="M. Rosario" last="Alonso">M. Rosario Alonso</name><affiliation><nlm:aff id="aff30">Centro Nacional de Genotipado Human Genotyping Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Alvarez, Nuria" sort="Alvarez, Nuria" uniqKey="Alvarez N" first="Nuria" last="Álvarez">Nuria Álvarez</name><affiliation><nlm:aff id="aff30">Centro Nacional de Genotipado Human Genotyping Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Herrero, Daniel" sort="Herrero, Daniel" uniqKey="Herrero D" first="Daniel" last="Herrero">Daniel Herrero</name><affiliation><nlm:aff id="aff30">Centro Nacional de Genotipado Human Genotyping Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Tessier, Daniel C" sort="Tessier, Daniel C" uniqKey="Tessier D" first="Daniel C." last="Tessier">Daniel C. Tessier</name><affiliation><nlm:aff id="aff145">McGill University and Génome Québec Innovation Centre, Montreal, QC H3A 0G1, Canada</nlm:aff></affiliation></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name><affiliation><nlm:aff id="aff145">McGill University and Génome Québec Innovation Centre, Montreal, QC H3A 0G1, Canada</nlm:aff></affiliation></author><author><name sortKey="Bacot, Francois" sort="Bacot, Francois" uniqKey="Bacot F" first="Francois" last="Bacot">Francois Bacot</name><affiliation><nlm:aff id="aff145">McGill University and Génome Québec Innovation Centre, Montreal, QC H3A 0G1, Canada</nlm:aff></affiliation></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Healey, Catherine S" sort="Healey, Catherine S" uniqKey="Healey C" first="Catherine S." last="Healey">Catherine S. Healey</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Brown, Melissa A" sort="Brown, Melissa A" uniqKey="Brown M" first="Melissa A." last="Brown">Melissa A. Brown</name><affiliation><nlm:aff id="aff5">School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia</nlm:aff></affiliation></author><author><name sortKey="Ponder, Bruce A J" sort="Ponder, Bruce A J" uniqKey="Ponder B" first="Bruce A. J." last="Ponder">Bruce A. J. Ponder</name><affiliation><nlm:aff id="aff4">Cancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="aff1">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Thompson, Deborah J" sort="Thompson, Deborah J" uniqKey="Thompson D" first="Deborah J." last="Thompson">Deborah J. Thompson</name><affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Edwards, Stacey L" sort="Edwards, Stacey L" uniqKey="Edwards S" first="Stacey L." last="Edwards">Stacey L. Edwards</name><affiliation><nlm:aff id="aff1">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="French, Juliet D" sort="French, Juliet D" uniqKey="French J" first="Juliet D." last="French">Juliet D. French</name><affiliation><nlm:aff id="aff1">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25529635</idno><idno type="pmc">4289692</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289692</idno><idno type="RBID">PMC:4289692</idno><idno type="doi">10.1016/j.ajhg.2014.11.009</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001688</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001688</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating <italic>MAP3K1</italic></title><author><name sortKey="Glubb, Dylan M" sort="Glubb, Dylan M" uniqKey="Glubb D" first="Dylan M." last="Glubb">Dylan M. Glubb</name><affiliation><nlm:aff id="aff1">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Maranian, Mel J" sort="Maranian, Mel J" uniqKey="Maranian M" first="Mel J." last="Maranian">Mel J. Maranian</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Meyer, Kerstin B" sort="Meyer, Kerstin B" uniqKey="Meyer K" first="Kerstin B." last="Meyer">Kerstin B. Meyer</name><affiliation><nlm:aff id="aff4">Cancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Kar, Siddhartha" sort="Kar, Siddhartha" uniqKey="Kar S" first="Siddhartha" last="Kar">Siddhartha Kar</name><affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Carlebur, Saskia" sort="Carlebur, Saskia" uniqKey="Carlebur S" first="Saskia" last="Carlebur">Saskia Carlebur</name><affiliation><nlm:aff id="aff4">Cancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Martin" sort="O Eilly, Martin" uniqKey="O Eilly M" first="Martin" last="O Eilly">Martin O Eilly</name><affiliation><nlm:aff id="aff4">Cancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Betts, Joshua A" sort="Betts, Joshua A" uniqKey="Betts J" first="Joshua A." last="Betts">Joshua A. Betts</name><affiliation><nlm:aff id="aff1">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia</nlm:aff></affiliation></author><author><name sortKey="Hillman, Kristine M" sort="Hillman, Kristine M" uniqKey="Hillman K" first="Kristine M." last="Hillman">Kristine M. Hillman</name><affiliation><nlm:aff id="aff1">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Kaufmann, Susanne" sort="Kaufmann, Susanne" uniqKey="Kaufmann S" first="Susanne" last="Kaufmann">Susanne Kaufmann</name><affiliation><nlm:aff id="aff1">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="aff1">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Canisius, Sander" sort="Canisius, Sander" uniqKey="Canisius S" first="Sander" last="Canisius">Sander Canisius</name><affiliation><nlm:aff id="aff6">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="aff7">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="aff8">Department of Pathology, University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation><nlm:aff id="aff8">Department of Pathology, University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="aff8">Department of Pathology, University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="aff6">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="aff6">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans B" sort="Hogervorst, Frans B" uniqKey="Hogervorst F" first="Frans B." last="Hogervorst">Frans B. Hogervorst</name><affiliation><nlm:aff id="aff6">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Schoot, C Ellen" sort="Van Der Schoot, C Ellen" uniqKey="Van Der Schoot C" first="C. Ellen" last="Van Der Schoot">C. Ellen Van Der Schoot</name><affiliation><nlm:aff id="aff9">Sanquin Research, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="aff10">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff11">Institute of Population Health, University of Manchester, Manchester M13 9PL, UK</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="aff10">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK</nlm:aff></affiliation></author><author><name sortKey="Stewart Brown, Sarah" sort="Stewart Brown, Sarah" uniqKey="Stewart Brown S" first="Sarah" last="Stewart-Brown">Sarah Stewart-Brown</name><affiliation><nlm:aff id="aff10">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK</nlm:aff></affiliation></author><author><name sortKey="Siriwanarangsan, Pornthep" sort="Siriwanarangsan, Pornthep" uniqKey="Siriwanarangsan P" first="Pornthep" last="Siriwanarangsan">Pornthep Siriwanarangsan</name><affiliation><nlm:aff id="aff12">Ministry of Public Health, Nonthaburi 11000, Thailand</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="aff13">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff14">Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA</nlm:aff></affiliation></author><author><name sortKey="Ruebner, Matthias" sort="Ruebner, Matthias" uniqKey="Ruebner M" first="Matthias" last="Ruebner">Matthias Ruebner</name><affiliation><nlm:aff id="aff13">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="aff15">Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="aff13">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="aff16">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:aff id="aff16">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="aff17">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="aff17">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="aff18">Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London SE1 9RT, UK</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="aff19">Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name><affiliation><nlm:aff id="aff20">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="aff20">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="aff21">Department of Obstetrics and Gynecology, University of Heidelberg, 69115 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="aff21">Department of Obstetrics and Gynecology, University of Heidelberg, 69115 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff22">National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Yang, Rongxi" sort="Yang, Rongxi" uniqKey="Yang R" first="Rongxi" last="Yang">Rongxi Yang</name><affiliation><nlm:aff id="aff21">Department of Obstetrics and Gynecology, University of Heidelberg, 69115 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff23">Molecular Genetics of Breast Cancer, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Surowy, Harald" sort="Surowy, Harald" uniqKey="Surowy H" first="Harald" last="Surowy">Harald Surowy</name><affiliation><nlm:aff id="aff21">Department of Obstetrics and Gynecology, University of Heidelberg, 69115 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff23">Molecular Genetics of Breast Cancer, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="aff24">Institut National de la Santé et de la Recherche Médicale U1018, Environmental Epidemiology of Cancers, Centre de Recherche en Epidémiologie et Santé des Populations, 94807 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff25">UMRS 1018, University Paris-Sud, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="aff24">Institut National de la Santé et de la Recherche Médicale U1018, Environmental Epidemiology of Cancers, Centre de Recherche en Epidémiologie et Santé des Populations, 94807 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff25">UMRS 1018, University Paris-Sud, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation><nlm:aff id="aff24">Institut National de la Santé et de la Recherche Médicale U1018, Environmental Epidemiology of Cancers, Centre de Recherche en Epidémiologie et Santé des Populations, 94807 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff25">UMRS 1018, University Paris-Sud, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Sanchez, Marie" sort="Sanchez, Marie" uniqKey="Sanchez M" first="Marie" last="Sanchez">Marie Sanchez</name><affiliation><nlm:aff id="aff24">Institut National de la Santé et de la Recherche Médicale U1018, Environmental Epidemiology of Cancers, Centre de Recherche en Epidémiologie et Santé des Populations, 94807 Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff25">UMRS 1018, University Paris-Sud, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="aff26">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="aff27">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="aff28">Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="aff26">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="aff27">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="aff28">Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="aff26">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="aff27">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="aff29">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation><nlm:aff id="aff30">Centro Nacional de Genotipado Human Genotyping Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="aff31">Centro de Investigación en Red de Enfermedades Raras, 46010 Valencia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="aff32">Human Genetics Group, Spanish National Cancer Centre and Biomedical Network on Rare Diseases, 28029 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="aff33">Servicio de Oncología Médica, Hospital Universitario La Paz, 28029 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Perez">Jose Ignacio Arias Perez</name><affiliation><nlm:aff id="aff34">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, 33012 Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="aff35">Department of Epidemiology, University of California, Irvine, Irvine, CA 92697, USA</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="aff36">Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="aff37">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff38">German Cancer Consortium, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Dieffenbach, Aida Karina" sort="Dieffenbach, Aida Karina" uniqKey="Dieffenbach A" first="Aida Karina" last="Dieffenbach">Aida Karina Dieffenbach</name><affiliation><nlm:aff id="aff37">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff38">German Cancer Consortium, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="aff37">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="aff39">Saarland Cancer Registry, 66024 Saarbrücken, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="aff40">Division of Gynaecology and Obstetrics, Technische Universität München, 81675 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="aff41">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, 50931 Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff42">Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology, Center for Molecular Medicine Cologne, University Hospital of Cologne, 50937 Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff43">Center for Molecular Medicine Cologne, University of Cologne, 50923 Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff44">Center for Integrated Oncology, Medical Faculty, University Hospital of Cologne, 50937 Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="aff45">University of Tübingen, 72074 Tübingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff46">Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, 70376 Stuttgart, Germany</nlm:aff></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation><nlm:aff id="aff47">Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, 53113 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="aff48">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, 44789 Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="aff50">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, 00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="aff50">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, 00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="aff51">Department of Clinical Genetics, Helsinki University Central Hospital, 00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="aff52">Department of Oncology, University of Helsinki and Helsinki University Central Hospital, 00029 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:aff id="aff53">Department of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan</nlm:aff></affiliation></author><author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name><affiliation><nlm:aff id="aff54">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan</nlm:aff></affiliation></author><author><name sortKey="Iwata, Hiroji" sort="Iwata, Hiroji" uniqKey="Iwata H" first="Hiroji" last="Iwata">Hiroji Iwata</name><affiliation><nlm:aff id="aff55">Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Hideo" sort="Tanaka, Hideo" uniqKey="Tanaka H" first="Hideo" last="Tanaka">Hideo Tanaka</name><affiliation><nlm:aff id="aff54">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="aff56">Gynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="aff57">Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Helbig, Sonja" sort="Helbig, Sonja" uniqKey="Helbig S" first="Sonja" last="Helbig">Sonja Helbig</name><affiliation><nlm:aff id="aff56">Gynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="aff58">Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="aff59">Department of Oncology-Pathology, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="aff60">Cancer Center of Eastern Finland, University of Eastern Finland, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff61">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff62">School of Medicine, Institute of Clinical Medicine, Pathology, and Forensic Medicine, University of Eastern Finland, 70211 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="aff60">Cancer Center of Eastern Finland, University of Eastern Finland, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff61">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff62">School of Medicine, Institute of Clinical Medicine, Pathology, and Forensic Medicine, University of Eastern Finland, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff63">Cancer Center, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="aff60">Cancer Center of Eastern Finland, University of Eastern Finland, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff61">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff62">School of Medicine, Institute of Clinical Medicine, Pathology, and Forensic Medicine, University of Eastern Finland, 70211 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="aff60">Cancer Center of Eastern Finland, University of Eastern Finland, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff61">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff62">School of Medicine, Institute of Clinical Medicine, Pathology, and Forensic Medicine, University of Eastern Finland, 70211 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H." last="Wu">Anna H. Wu</name><affiliation><nlm:aff id="aff65">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name><affiliation><nlm:aff id="aff65">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, David" sort="Van Den Berg, David" uniqKey="Van Den Berg D" first="David" last="Van Den Berg">David Van Den Berg</name><affiliation><nlm:aff id="aff65">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name><affiliation><nlm:aff id="aff65">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="aff66">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, 3000 Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="aff67">Vesalius Research Center, VIB, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Zhao, Hui" sort="Zhao, Hui" uniqKey="Zhao H" first="Hui" last="Zhao">Hui Zhao</name><affiliation><nlm:aff id="aff66">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, 3000 Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="aff67">Vesalius Research Center, VIB, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Weltens, Caroline" sort="Weltens, Caroline" uniqKey="Weltens C" first="Caroline" last="Weltens">Caroline Weltens</name><affiliation><nlm:aff id="aff68">University Hospital Gashuisberg, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Van Limbergen, Erik" sort="Van Limbergen, Erik" uniqKey="Van Limbergen E" first="Erik" last="Van Limbergen">Erik Van Limbergen</name><affiliation><nlm:aff id="aff68">University Hospital Gashuisberg, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="aff69">Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="aff70">Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, 20246 Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="aff69">Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Seibold, Petra" sort="Seibold, Petra" uniqKey="Seibold P" first="Petra" last="Seibold">Petra Seibold</name><affiliation><nlm:aff id="aff69">Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="aff71">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Istituto Nazionale Tumori, Fondazione Istituto Neurologico Carlo Besta, 20133 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="aff72">Istituto Fondazione Italiana per la Ricerca sul Cancro di Oncologia Molecolare, 20139 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><affiliation><nlm:aff id="aff73">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, 20141 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Capra, Fabio" sort="Capra, Fabio" uniqKey="Capra F" first="Fabio" last="Capra">Fabio Capra</name><affiliation><nlm:aff id="aff72">Istituto Fondazione Italiana per la Ricerca sul Cancro di Oncologia Molecolare, 20139 Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="aff74">Cogentech Cancer Genetic Test Laboratory, 20139 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="aff75">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="aff76">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Hallberg, Emily" sort="Hallberg, Emily" uniqKey="Hallberg E" first="Emily" last="Hallberg">Emily Hallberg</name><affiliation><nlm:aff id="aff76">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="aff76">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="aff6">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="aff77">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="aff6">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="aff77">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="aff78">Anatomical Pathology, The Alfred, Melbourne, VIC 3004, Australia</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="aff65">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="aff65">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation><nlm:aff id="aff65">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="aff79">University of Hawaii Cancer Centre Honolulu, HI 96813, USA</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="aff80">Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, QC G1V 4G2, Canada</nlm:aff></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name><affiliation><nlm:aff id="aff81">Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC H3A 1A1, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="aff82">Department of Medicine, McGill University, Montreal, QC H3A 1A1, Canada</nlm:aff></affiliation></author><author><name sortKey="Labreche, France" sort="Labreche, France" uniqKey="Labreche F" first="France" last="Labrèche">France Labrèche</name><affiliation><nlm:aff id="aff83">Département de Médecine Sociale et Préventive, Département de Santé Environnementale et Santé au Travail, Université de Montréal, Montreal, QC H3A 3C2, Canada</nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="aff80">Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, QC G1V 4G2, Canada</nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo Hwang" last="Teo">Soo Hwang Teo</name><affiliation><nlm:aff id="aff84">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 47500 Subang Jaya, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="aff85">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng Har" last="Yip">Cheng Har Yip</name><affiliation><nlm:aff id="aff85">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="See, Mee Hoong" sort="See, Mee Hoong" uniqKey="See M" first="Mee-Hoong" last="See">Mee-Hoong See</name><affiliation><nlm:aff id="aff85">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Cornes, Belinda" sort="Cornes, Belinda" uniqKey="Cornes B" first="Belinda" last="Cornes">Belinda Cornes</name><affiliation><nlm:aff id="aff86">Singapore Eye Research Institute, National University of Singapore, Singapore 168751, Singapore</nlm:aff></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name><affiliation><nlm:aff id="aff86">Singapore Eye Research Institute, National University of Singapore, Singapore 168751, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ikram, M Kamran" sort="Ikram, M Kamran" uniqKey="Ikram M" first="M. Kamran" last="Ikram">M. Kamran Ikram</name><affiliation><nlm:aff id="aff86">Singapore Eye Research Institute, National University of Singapore, Singapore 168751, Singapore</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="aff87">Institute of Clinical Medicine, University of Oslo, 0450 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="aff88">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="aff89">Department of Clinical Molecular Biology, University of Oslo, 0450 Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Halverson, Sandra L" sort="Halverson, Sandra L" uniqKey="Halverson S" first="Sandra L." last="Halverson">Sandra L. Halverson</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Martha" sort="Shrubsole, Martha" uniqKey="Shrubsole M" first="Martha" last="Shrubsole">Martha Shrubsole</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="aff103">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu, Oulu University Hospital, 90210 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="aff103">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu, Oulu University Hospital, 90210 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="aff104">Department of Oncology, Oulu University Hospital, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kauppila, Saila" sort="Kauppila, Saila" uniqKey="Kauppila S" first="Saila" last="Kauppila">Saila Kauppila</name><affiliation><nlm:aff id="aff105">Department of Pathology, Oulu University Hospital, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="aff106">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="aff107">Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="aff108">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="aff109">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="aff110">Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name><affiliation><nlm:aff id="aff110">Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="aff111">Departments of Human Genetics and Pathology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="aff111">Departments of Human Genetics and Pathology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><affiliation><nlm:aff id="aff112">Family Cancer Clinic, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J." last="Van Asperen">Christi J. Van Asperen</name><affiliation><nlm:aff id="aff113">Department of Clinical Genetics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="aff17">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff114">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="aff115">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="aff115">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="aff116">Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="aff117">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Klevebring, Daniel" sort="Klevebring, Daniel" uniqKey="Klevebring D" first="Daniel" last="Klevebring">Daniel Klevebring</name><affiliation><nlm:aff id="aff117">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="aff117">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name><affiliation><nlm:aff id="aff117">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="aff118">Department of Medical Oncology, Erasmus University Medical Center Cancer Institute, 3075 EA Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="aff118">Department of Medical Oncology, Erasmus University Medical Center Cancer Institute, 3075 EA Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation><nlm:aff id="aff118">Department of Medical Oncology, Erasmus University Medical Center Cancer Institute, 3075 EA Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J. Margriet" last="Collée">J. Margriet Collée</name><affiliation><nlm:aff id="aff119">Department of Clinical Genetics, Erasmus University Medical Center, 3008 AE Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="aff117">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="aff120">Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="aff117">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Lu, Wei" sort="Lu, Wei" uniqKey="Lu W" first="Wei" last="Lu">Wei Lu</name><affiliation><nlm:aff id="aff121">Shanghai Center for Disease Control and Prevention, Changning, Shanghai 200336, China</nlm:aff></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation><nlm:aff id="aff122">Department of Epidemiology, Shanghai Cancer Institute, Shanghai 200032, China</nlm:aff></affiliation></author><author><name sortKey="Cai, Hui" sort="Cai, Hui" uniqKey="Cai H" first="Hui" last="Cai">Hui Cai</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="aff123">Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="aff124">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2RX, UK</nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="aff123">Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK</nlm:aff></affiliation></author><author><name sortKey="Blot, William" sort="Blot, William" uniqKey="Blot W" first="William" last="Blot">William Blot</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation><affiliation><nlm:aff id="aff125">International Epidemiology Institute, Rockville, MD 20850, USA</nlm:aff></affiliation></author><author><name sortKey="Signorello, Lisa B" sort="Signorello, Lisa B" uniqKey="Signorello L" first="Lisa B." last="Signorello">Lisa B. Signorello</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation><affiliation><nlm:aff id="aff125">International Epidemiology Institute, Rockville, MD 20850, USA</nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="aff102">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="aff126">Department of Preventive Medicine, Seoul National University College of Medicine and Cancer Research Institute, Seoul National University, Seoul 110-799, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="aff127">Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 151-742, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="aff128">Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation></author><author><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name><affiliation><nlm:aff id="aff127">Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 151-742, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="aff128">Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation></author><author><name sortKey="Park, Sue K" sort="Park, Sue K" uniqKey="Park S" first="Sue K." last="Park">Sue K. Park</name><affiliation><nlm:aff id="aff126">Department of Preventive Medicine, Seoul National University College of Medicine and Cancer Research Institute, Seoul National University, Seoul 110-799, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="aff127">Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 151-742, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="aff128">Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation></author><author><name sortKey="Noh, Dong Young" sort="Noh, Dong Young" uniqKey="Noh D" first="Dong-Young" last="Noh">Dong-Young Noh</name><affiliation><nlm:aff id="aff129">Department of Surgery, Seoul National University, Bundang Hospital, Seongnam 110-744, Korea</nlm:aff></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation><nlm:aff id="aff130">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="aff131">Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore 119228, Singapore</nlm:aff></affiliation></author><author><name sortKey="Miao, Hui" sort="Miao, Hui" uniqKey="Miao H" first="Hui" last="Miao">Hui Miao</name><affiliation><nlm:aff id="aff130">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore</nlm:aff></affiliation></author><author><name sortKey="Lim, Wei Yen" sort="Lim, Wei Yen" uniqKey="Lim W" first="Wei Yen" last="Lim">Wei Yen Lim</name><affiliation><nlm:aff id="aff130">Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore</nlm:aff></affiliation></author><author><name sortKey="Tang, Anthony" sort="Tang, Anthony" uniqKey="Tang A" first="Anthony" last="Tang">Anthony Tang</name><affiliation><nlm:aff id="aff132">Division of General Surgery, National University Health System, Singapore 119228, Singapore</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="aff23">Molecular Genetics of Breast Cancer, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation><nlm:aff id="aff23">Molecular Genetics of Breast Cancer, German Cancer Research Center, 69120 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff133">Institute of Human Genetics, Pontificia Universidad Javeriana, Bogotá 11001000, Colombia</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="aff134">Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="aff134">Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="aff134">Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="aff134">Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="aff135">National Cancer Institute, Bangkok 10400, Thailand</nlm:aff></affiliation></author><author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name><affiliation><nlm:aff id="aff136">International Agency for Research on Cancer, 69372 Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="aff136">International Agency for Research on Cancer, 69372 Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name><affiliation><nlm:aff id="aff136">International Agency for Research on Cancer, 69372 Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Olswold, Curtis" sort="Olswold, Curtis" uniqKey="Olswold C" first="Curtis" last="Olswold">Curtis Olswold</name><affiliation><nlm:aff id="aff76">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation><nlm:aff id="aff76">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="aff137">Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA</nlm:aff></affiliation></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><affiliation><nlm:aff id="aff138">Molecular Diagnostics Laboratory, Institute of Radioisotopes and Radiodiagnostic Products, National Centre for Scientific Research “Demokritos,” Aghia Paraskevi Attikis, Athens 15310, Greece</nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="aff139">Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="aff140">School of Public Health, China Medical University, Taichung 40402, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="aff141">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Wu, Pei Ei" sort="Wu, Pei Ei" uniqKey="Wu P" first="Pei-Ei" last="Wu">Pei-Ei Wu</name><affiliation><nlm:aff id="aff139">Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="aff141">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Yu, Jyh Cherng" sort="Yu, Jyh Cherng" uniqKey="Yu J" first="Jyh-Cherng" last="Yu">Jyh-Cherng Yu</name><affiliation><nlm:aff id="aff142">Department of Surgery, Tri-Service General Hospital, Taipei 114, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hou, Ming Feng" sort="Hou, Ming Feng" uniqKey="Hou M" first="Ming-Feng" last="Hou">Ming-Feng Hou</name><affiliation><nlm:aff id="aff143">Cancer Center and Department of Surgery, Kaohsiung Medical University, Chung-Ho Memorial Hospital, Kaohsiung 807, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="aff114">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff144">Division of Breast Cancer Research, Institute of Cancer Research, Sutton SM2 5NG, UK</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="aff17">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="aff17">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation><nlm:aff id="aff114">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK</nlm:aff></affiliation></author><author><name sortKey="Pita, Guillermo" sort="Pita, Guillermo" uniqKey="Pita G" first="Guillermo" last="Pita">Guillermo Pita</name><affiliation><nlm:aff id="aff30">Centro Nacional de Genotipado Human Genotyping Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Alonso, M Rosario" sort="Alonso, M Rosario" uniqKey="Alonso M" first="M. Rosario" last="Alonso">M. Rosario Alonso</name><affiliation><nlm:aff id="aff30">Centro Nacional de Genotipado Human Genotyping Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Alvarez, Nuria" sort="Alvarez, Nuria" uniqKey="Alvarez N" first="Nuria" last="Álvarez">Nuria Álvarez</name><affiliation><nlm:aff id="aff30">Centro Nacional de Genotipado Human Genotyping Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Herrero, Daniel" sort="Herrero, Daniel" uniqKey="Herrero D" first="Daniel" last="Herrero">Daniel Herrero</name><affiliation><nlm:aff id="aff30">Centro Nacional de Genotipado Human Genotyping Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Tessier, Daniel C" sort="Tessier, Daniel C" uniqKey="Tessier D" first="Daniel C." last="Tessier">Daniel C. Tessier</name><affiliation><nlm:aff id="aff145">McGill University and Génome Québec Innovation Centre, Montreal, QC H3A 0G1, Canada</nlm:aff></affiliation></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name><affiliation><nlm:aff id="aff145">McGill University and Génome Québec Innovation Centre, Montreal, QC H3A 0G1, Canada</nlm:aff></affiliation></author><author><name sortKey="Bacot, Francois" sort="Bacot, Francois" uniqKey="Bacot F" first="Francois" last="Bacot">Francois Bacot</name><affiliation><nlm:aff id="aff145">McGill University and Génome Québec Innovation Centre, Montreal, QC H3A 0G1, Canada</nlm:aff></affiliation></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Healey, Catherine S" sort="Healey, Catherine S" uniqKey="Healey C" first="Catherine S." last="Healey">Catherine S. Healey</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Brown, Melissa A" sort="Brown, Melissa A" uniqKey="Brown M" first="Melissa A." last="Brown">Melissa A. Brown</name><affiliation><nlm:aff id="aff5">School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia</nlm:aff></affiliation></author><author><name sortKey="Ponder, Bruce A J" sort="Ponder, Bruce A J" uniqKey="Ponder B" first="Bruce A. J." last="Ponder">Bruce A. J. Ponder</name><affiliation><nlm:aff id="aff4">Cancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="aff1">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Thompson, Deborah J" sort="Thompson, Deborah J" uniqKey="Thompson D" first="Deborah J." last="Thompson">Deborah J. Thompson</name><affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Edwards, Stacey L" sort="Edwards, Stacey L" uniqKey="Edwards S" first="Stacey L." last="Edwards">Stacey L. Edwards</name><affiliation><nlm:aff id="aff1">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="French, Juliet D" sort="French, Juliet D" uniqKey="French J" first="Juliet D." last="French">Juliet D. French</name><affiliation><nlm:aff id="aff1">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia</nlm:aff></affiliation></author></analytic><series><title level="j">American Journal of Human Genetics</title><idno type="ISSN">0002-9297</idno><idno type="eISSN">1537-6605</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Genome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an attempt to identify the biologically relevant variants, we analyzed 909 genetic variants across 5q11.2 in 103,991 breast cancer individuals and control individuals from 52 studies in the Breast Cancer Association Consortium. Multiple logistic regression analyses identified three independent risk signals: the strongest associations were with 15 correlated variants (iCHAV1), where the minor allele of the best candidate, rs62355902, associated with significantly increased risks of both estrogen-receptor-positive (ER<sup>+</sup>: odds ratio [OR] = 1.24, 95% confidence interval [CI] = 1.21–1.27, p<sub>trend</sub> = 5.7 × 10<sup>−44</sup>) and estrogen-receptor-negative (ER<sup>−</sup>: OR = 1.10, 95% CI = 1.05–1.15, p<sub>trend</sub> = 3.0 × 10<sup>−4</sup>) tumors. After adjustment for rs62355902, we found evidence of association of a further 173 variants (iCHAV2) containing three subsets with a range of effects (the strongest was rs113317823 [p<sub>cond</sub> = 1.61 × 10<sup>−5</sup>]) and five variants composing iCHAV3 (lead rs11949391; ER<sup>+</sup>: OR = 0.90, 95% CI = 0.87–0.93, p<sub>cond</sub> = 1.4 × 10<sup>−4</sup>). Twenty-six percent of the prioritized candidate variants coincided with four putative regulatory elements that interact with the <italic>MAP3K1</italic> promoter through chromatin looping and affect <italic>MAP3K1</italic> promoter activity. Functional analysis indicated that the cancer risk alleles of four candidates (rs74345699 and rs62355900 [iCHAV1], rs16886397 [iCHAV2a], and rs17432750 [iCHAV3]) increased <italic>MAP3K1</italic> transcriptional activity. Chromatin immunoprecipitation analysis revealed diminished GATA3 binding to the minor (cancer-protective) allele of rs17432750, indicating a mechanism for its action. We propose that the cancer risk alleles act to increase <italic>MAP3K1</italic> expression in vivo and might promote breast cancer cell survival.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Hum Genet</journal-id><journal-id journal-id-type="iso-abbrev">Am. J. Hum. Genet</journal-id><journal-title-group><journal-title>American Journal of Human Genetics</journal-title></journal-title-group><issn pub-type="ppub">0002-9297</issn><issn pub-type="epub">1537-6605</issn><publisher><publisher-name>Elsevier</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25529635</article-id><article-id pub-id-type="pmc">4289692</article-id><article-id pub-id-type="publisher-id">S0002-9297(14)00475-3</article-id><article-id pub-id-type="doi">10.1016/j.ajhg.2014.11.009</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating <italic>MAP3K1</italic></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Glubb</surname><given-names>Dylan M.</given-names></name><xref rid="aff1" ref-type="aff">1</xref><xref rid="fn2" ref-type="fn">147</xref></contrib><contrib contrib-type="author"><name><surname>Maranian</surname><given-names>Mel J.</given-names></name><xref rid="aff2" ref-type="aff">2</xref><xref rid="fn2" ref-type="fn">147</xref></contrib><contrib contrib-type="author"><name><surname>Michailidou</surname><given-names>Kyriaki</given-names></name><xref rid="aff3" ref-type="aff">3</xref><xref rid="fn2" ref-type="fn">147</xref></contrib><contrib contrib-type="author"><name><surname>Pooley</surname><given-names>Karen A.</given-names></name><xref rid="aff2" ref-type="aff">2</xref><xref rid="fn2" ref-type="fn">147</xref></contrib><contrib contrib-type="author"><name><surname>Meyer</surname><given-names>Kerstin B.</given-names></name><xref rid="aff4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Kar</surname><given-names>Siddhartha</given-names></name><xref rid="aff3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Carlebur</surname><given-names>Saskia</given-names></name><xref rid="aff4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>O’Reilly</surname><given-names>Martin</given-names></name><xref rid="aff4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Betts</surname><given-names>Joshua A.</given-names></name><xref rid="aff1" ref-type="aff">1</xref><xref rid="aff5" ref-type="aff">5</xref></contrib><contrib contrib-type="author"><name><surname>Hillman</surname><given-names>Kristine M.</given-names></name><xref rid="aff1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Kaufmann</surname><given-names>Susanne</given-names></name><xref rid="aff1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Beesley</surname><given-names>Jonathan</given-names></name><xref rid="aff1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Canisius</surname><given-names>Sander</given-names></name><xref rid="aff6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John L.</given-names></name><xref rid="aff7" ref-type="aff">7</xref></contrib><contrib contrib-type="author"><name><surname>Southey</surname><given-names>Melissa C.</given-names></name><xref rid="aff8" ref-type="aff">8</xref></contrib><contrib contrib-type="author"><name><surname>Tsimiklis</surname><given-names>Helen</given-names></name><xref rid="aff8" ref-type="aff">8</xref></contrib><contrib contrib-type="author"><name><surname>Apicella</surname><given-names>Carmel</given-names></name><xref rid="aff8" ref-type="aff">8</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Marjanka K.</given-names></name><xref rid="aff6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Broeks</surname><given-names>Annegien</given-names></name><xref rid="aff6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Hogervorst</surname><given-names>Frans B.</given-names></name><xref rid="aff6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>van der Schoot</surname><given-names>C. 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contrib-type="author"><name><surname>Ko</surname><given-names>Yon-Dschun</given-names></name><xref rid="aff47" ref-type="aff">47</xref></contrib><contrib contrib-type="author"><name><surname>Brüning</surname><given-names>Thomas</given-names></name><xref rid="aff48" ref-type="aff">48</xref></contrib><contrib contrib-type="author"><collab>The GENICA Network</collab><xref rid="aff23" ref-type="aff">23</xref><xref rid="aff45" ref-type="aff">45</xref><xref rid="aff46" ref-type="aff">46</xref><xref rid="aff47" ref-type="aff">47</xref><xref rid="aff48" ref-type="aff">48</xref><xref rid="aff49" ref-type="aff">49</xref></contrib><contrib contrib-type="author"><name><surname>Nevanlinna</surname><given-names>Heli</given-names></name><xref rid="aff50" ref-type="aff">50</xref></contrib><contrib contrib-type="author"><name><surname>Muranen</surname><given-names>Taru A.</given-names></name><xref rid="aff50" ref-type="aff">50</xref></contrib><contrib 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contrib-type="author"><name><surname>Dörk</surname><given-names>Thilo</given-names></name><xref rid="aff56" ref-type="aff">56</xref></contrib><contrib contrib-type="author"><name><surname>Bogdanova</surname><given-names>Natalia V.</given-names></name><xref rid="aff57" ref-type="aff">57</xref></contrib><contrib contrib-type="author"><name><surname>Helbig</surname><given-names>Sonja</given-names></name><xref rid="aff56" ref-type="aff">56</xref></contrib><contrib contrib-type="author"><name><surname>Lindblom</surname><given-names>Annika</given-names></name><xref rid="aff58" ref-type="aff">58</xref></contrib><contrib contrib-type="author"><name><surname>Margolin</surname><given-names>Sara</given-names></name><xref rid="aff59" ref-type="aff">59</xref></contrib><contrib contrib-type="author"><name><surname>Mannermaa</surname><given-names>Arto</given-names></name><xref rid="aff60" ref-type="aff">60</xref><xref rid="aff61" ref-type="aff">61</xref><xref rid="aff62" 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contrib-type="author"><name><surname>Weltens</surname><given-names>Caroline</given-names></name><xref rid="aff68" ref-type="aff">68</xref></contrib><contrib contrib-type="author"><name><surname>van Limbergen</surname><given-names>Erik</given-names></name><xref rid="aff68" ref-type="aff">68</xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><xref rid="aff69" ref-type="aff">69</xref></contrib><contrib contrib-type="author"><name><surname>Flesch-Janys</surname><given-names>Dieter</given-names></name><xref rid="aff70" ref-type="aff">70</xref></contrib><contrib contrib-type="author"><name><surname>Rudolph</surname><given-names>Anja</given-names></name><xref rid="aff69" ref-type="aff">69</xref></contrib><contrib contrib-type="author"><name><surname>Seibold</surname><given-names>Petra</given-names></name><xref rid="aff69" ref-type="aff">69</xref></contrib><contrib contrib-type="author"><name><surname>Radice</surname><given-names>Paolo</given-names></name><xref rid="aff71" ref-type="aff">71</xref></contrib><contrib contrib-type="author"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name><xref rid="aff72" ref-type="aff">72</xref></contrib><contrib contrib-type="author"><name><surname>Barile</surname><given-names>Monica</given-names></name><xref rid="aff73" ref-type="aff">73</xref></contrib><contrib contrib-type="author"><name><surname>Capra</surname><given-names>Fabio</given-names></name><xref rid="aff72" ref-type="aff">72</xref><xref rid="aff74" ref-type="aff">74</xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus J.</given-names></name><xref rid="aff75" ref-type="aff">75</xref></contrib><contrib contrib-type="author"><name><surname>Olson</surname><given-names>Janet E.</given-names></name><xref rid="aff76" ref-type="aff">76</xref></contrib><contrib 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ref-type="aff">83</xref></contrib><contrib contrib-type="author"><name><surname>Dumont</surname><given-names>Martine</given-names></name><xref rid="aff80" ref-type="aff">80</xref></contrib><contrib contrib-type="author"><name><surname>Teo</surname><given-names>Soo Hwang</given-names></name><xref rid="aff84" ref-type="aff">84</xref><xref rid="aff85" ref-type="aff">85</xref></contrib><contrib contrib-type="author"><name><surname>Yip</surname><given-names>Cheng Har</given-names></name><xref rid="aff85" ref-type="aff">85</xref></contrib><contrib contrib-type="author"><name><surname>See</surname><given-names>Mee-Hoong</given-names></name><xref rid="aff85" ref-type="aff">85</xref></contrib><contrib contrib-type="author"><name><surname>Cornes</surname><given-names>Belinda</given-names></name><xref rid="aff86" ref-type="aff">86</xref></contrib><contrib contrib-type="author"><name><surname>Cheng</surname><given-names>Ching-Yu</given-names></name><xref rid="aff86" 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contrib-type="author"><name><surname>Jukkola-Vuorinen</surname><given-names>Arja</given-names></name><xref rid="aff104" ref-type="aff">104</xref></contrib><contrib contrib-type="author"><name><surname>Kauppila</surname><given-names>Saila</given-names></name><xref rid="aff105" ref-type="aff">105</xref></contrib><contrib contrib-type="author"><name><surname>Andrulis</surname><given-names>Irene L.</given-names></name><xref rid="aff106" ref-type="aff">106</xref><xref rid="aff107" ref-type="aff">107</xref></contrib><contrib contrib-type="author"><name><surname>Knight</surname><given-names>Julia A.</given-names></name><xref rid="aff108" ref-type="aff">108</xref><xref rid="aff109" ref-type="aff">109</xref></contrib><contrib contrib-type="author"><name><surname>Glendon</surname><given-names>Gord</given-names></name><xref rid="aff110" ref-type="aff">110</xref></contrib><contrib contrib-type="author"><name><surname>Tchatchou</surname><given-names>Sandrine</given-names></name><xref rid="aff110" 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Margriet</given-names></name><xref rid="aff119" ref-type="aff">119</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><xref rid="aff117" ref-type="aff">117</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Jingmei</given-names></name><xref rid="aff120" ref-type="aff">120</xref></contrib><contrib contrib-type="author"><name><surname>Humphreys</surname><given-names>Keith</given-names></name><xref rid="aff117" ref-type="aff">117</xref></contrib><contrib contrib-type="author"><name><surname>Shu</surname><given-names>Xiao-Ou</given-names></name><xref rid="aff102" ref-type="aff">102</xref></contrib><contrib contrib-type="author"><name><surname>Lu</surname><given-names>Wei</given-names></name><xref rid="aff121" ref-type="aff">121</xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Yu-Tang</given-names></name><xref rid="aff122" ref-type="aff">122</xref></contrib><contrib contrib-type="author"><name><surname>Cai</surname><given-names>Hui</given-names></name><xref rid="aff102" ref-type="aff">102</xref></contrib><contrib contrib-type="author"><name><surname>Cox</surname><given-names>Angela</given-names></name><xref rid="aff123" ref-type="aff">123</xref></contrib><contrib contrib-type="author"><name><surname>Cross</surname><given-names>Simon S.</given-names></name><xref rid="aff124" ref-type="aff">124</xref></contrib><contrib contrib-type="author"><name><surname>Reed</surname><given-names>Malcolm W.R.</given-names></name><xref rid="aff123" ref-type="aff">123</xref></contrib><contrib contrib-type="author"><name><surname>Blot</surname><given-names>William</given-names></name><xref rid="aff102" ref-type="aff">102</xref><xref rid="aff125" ref-type="aff">125</xref></contrib><contrib contrib-type="author"><name><surname>Signorello</surname><given-names>Lisa B.</given-names></name><xref rid="aff102" ref-type="aff">102</xref><xref rid="aff125" ref-type="aff">125</xref></contrib><contrib contrib-type="author"><name><surname>Cai</surname><given-names>Qiuyin</given-names></name><xref rid="aff102" ref-type="aff">102</xref></contrib><contrib contrib-type="author"><name><surname>Shah</surname><given-names>Mitul</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Ghoussaini</surname><given-names>Maya</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Kang</surname><given-names>Daehee</given-names></name><xref rid="aff126" ref-type="aff">126</xref><xref rid="aff127" ref-type="aff">127</xref><xref rid="aff128" ref-type="aff">128</xref></contrib><contrib contrib-type="author"><name><surname>Choi</surname><given-names>Ji-Yeob</given-names></name><xref rid="aff127" ref-type="aff">127</xref><xref rid="aff128" ref-type="aff">128</xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Sue K.</given-names></name><xref rid="aff126" ref-type="aff">126</xref><xref rid="aff127" ref-type="aff">127</xref><xref rid="aff128" ref-type="aff">128</xref></contrib><contrib contrib-type="author"><name><surname>Noh</surname><given-names>Dong-Young</given-names></name><xref rid="aff129" ref-type="aff">129</xref></contrib><contrib contrib-type="author"><name><surname>Hartman</surname><given-names>Mikael</given-names></name><xref rid="aff130" ref-type="aff">130</xref><xref rid="aff131" ref-type="aff">131</xref></contrib><contrib contrib-type="author"><name><surname>Miao</surname><given-names>Hui</given-names></name><xref rid="aff130" ref-type="aff">130</xref></contrib><contrib contrib-type="author"><name><surname>Lim</surname><given-names>Wei Yen</given-names></name><xref rid="aff130" ref-type="aff">130</xref></contrib><contrib contrib-type="author"><name><surname>Tang</surname><given-names>Anthony</given-names></name><xref rid="aff132" ref-type="aff">132</xref></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name><xref rid="aff23" ref-type="aff">23</xref></contrib><contrib contrib-type="author"><name><surname>Torres</surname><given-names>Diana</given-names></name><xref rid="aff23" ref-type="aff">23</xref><xref rid="aff133" ref-type="aff">133</xref></contrib><contrib contrib-type="author"><name><surname>Jakubowska</surname><given-names>Anna</given-names></name><xref rid="aff134" ref-type="aff">134</xref></contrib><contrib contrib-type="author"><name><surname>Lubinski</surname><given-names>Jan</given-names></name><xref rid="aff134" ref-type="aff">134</xref></contrib><contrib contrib-type="author"><name><surname>Jaworska</surname><given-names>Katarzyna</given-names></name><xref rid="aff134" ref-type="aff">134</xref></contrib><contrib contrib-type="author"><name><surname>Durda</surname><given-names>Katarzyna</given-names></name><xref rid="aff134" ref-type="aff">134</xref></contrib><contrib contrib-type="author"><name><surname>Sangrajrang</surname><given-names>Suleeporn</given-names></name><xref rid="aff135" ref-type="aff">135</xref></contrib><contrib contrib-type="author"><name><surname>Gaborieau</surname><given-names>Valerie</given-names></name><xref rid="aff136" ref-type="aff">136</xref></contrib><contrib contrib-type="author"><name><surname>Brennan</surname><given-names>Paul</given-names></name><xref rid="aff136" ref-type="aff">136</xref></contrib><contrib contrib-type="author"><name><surname>McKay</surname><given-names>James</given-names></name><xref rid="aff136" ref-type="aff">136</xref></contrib><contrib contrib-type="author"><name><surname>Olswold</surname><given-names>Curtis</given-names></name><xref rid="aff76" ref-type="aff">76</xref></contrib><contrib contrib-type="author"><name><surname>Slager</surname><given-names>Susan</given-names></name><xref rid="aff76" ref-type="aff">76</xref></contrib><contrib contrib-type="author"><name><surname>Toland</surname><given-names>Amanda E.</given-names></name><xref rid="aff137" ref-type="aff">137</xref></contrib><contrib contrib-type="author"><name><surname>Yannoukakos</surname><given-names>Drakoulis</given-names></name><xref rid="aff138" ref-type="aff">138</xref></contrib><contrib contrib-type="author"><name><surname>Shen</surname><given-names>Chen-Yang</given-names></name><xref rid="aff139" ref-type="aff">139</xref><xref rid="aff140" ref-type="aff">140</xref><xref rid="aff141" ref-type="aff">141</xref></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Pei-Ei</given-names></name><xref rid="aff139" ref-type="aff">139</xref><xref rid="aff141" ref-type="aff">141</xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>Jyh-Cherng</given-names></name><xref rid="aff142" ref-type="aff">142</xref></contrib><contrib contrib-type="author"><name><surname>Hou</surname><given-names>Ming-Feng</given-names></name><xref rid="aff143" ref-type="aff">143</xref></contrib><contrib contrib-type="author"><name><surname>Swerdlow</surname><given-names>Anthony</given-names></name><xref rid="aff114" ref-type="aff">114</xref><xref rid="aff144" ref-type="aff">144</xref></contrib><contrib contrib-type="author"><name><surname>Ashworth</surname><given-names>Alan</given-names></name><xref rid="aff17" ref-type="aff">17</xref></contrib><contrib contrib-type="author"><name><surname>Orr</surname><given-names>Nick</given-names></name><xref rid="aff17" ref-type="aff">17</xref></contrib><contrib contrib-type="author"><name><surname>Jones</surname><given-names>Michael</given-names></name><xref rid="aff114" ref-type="aff">114</xref></contrib><contrib contrib-type="author"><name><surname>Pita</surname><given-names>Guillermo</given-names></name><xref rid="aff30" ref-type="aff">30</xref></contrib><contrib contrib-type="author"><name><surname>Alonso</surname><given-names>M. Rosario</given-names></name><xref rid="aff30" ref-type="aff">30</xref></contrib><contrib contrib-type="author"><name><surname>Álvarez</surname><given-names>Nuria</given-names></name><xref rid="aff30" ref-type="aff">30</xref></contrib><contrib contrib-type="author"><name><surname>Herrero</surname><given-names>Daniel</given-names></name><xref rid="aff30" ref-type="aff">30</xref></contrib><contrib contrib-type="author"><name><surname>Tessier</surname><given-names>Daniel C.</given-names></name><xref rid="aff145" ref-type="aff">145</xref></contrib><contrib contrib-type="author"><name><surname>Vincent</surname><given-names>Daniel</given-names></name><xref rid="aff145" ref-type="aff">145</xref></contrib><contrib contrib-type="author"><name><surname>Bacot</surname><given-names>Francois</given-names></name><xref rid="aff145" ref-type="aff">145</xref></contrib><contrib contrib-type="author"><name><surname>Luccarini</surname><given-names>Craig</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Baynes</surname><given-names>Caroline</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Ahmed</surname><given-names>Shahana</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Healey</surname><given-names>Catherine S.</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Brown</surname><given-names>Melissa A.</given-names></name><xref rid="aff5" ref-type="aff">5</xref></contrib><contrib contrib-type="author"><name><surname>Ponder</surname><given-names>Bruce A.J.</given-names></name><xref rid="aff4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref rid="aff1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Thompson</surname><given-names>Deborah J.</given-names></name><xref rid="aff3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Edwards</surname><given-names>Stacey L.</given-names></name><xref rid="aff1" ref-type="aff">1</xref><xref rid="aff5" ref-type="aff">5</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref rid="aff2" ref-type="aff">2</xref><xref rid="aff3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M.</given-names></name><email>amd24@medschl.cam.ac.uk</email><xref rid="aff2" ref-type="aff">2</xref><xref rid="fn3" ref-type="fn">148</xref><xref rid="cor1" ref-type="corresp">∗</xref></contrib><contrib contrib-type="author"><name><surname>French</surname><given-names>Juliet D.</given-names></name><email>juliet.french@qimrberghofer.edu.au</email><xref rid="aff1" ref-type="aff">1</xref><xref rid="aff5" ref-type="aff">5</xref><xref rid="fn3" ref-type="fn">148</xref><xref rid="cor2" ref-type="corresp">∗∗</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</aff><aff id="aff2"><label>2</label>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</aff><aff id="aff3"><label>3</label>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</aff><aff id="aff4"><label>4</label>Cancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</aff><aff id="aff5"><label>5</label>School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia</aff><aff id="aff6"><label>6</label>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</aff><aff id="aff7"><label>7</label>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC 3010, Australia</aff><aff id="aff8"><label>8</label>Department of Pathology, University of Melbourne, Melbourne, VIC 3010, Australia</aff><aff id="aff9"><label>9</label>Sanquin Research, 1066 CX Amsterdam, the Netherlands</aff><aff id="aff10"><label>10</label>Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK</aff><aff id="aff11"><label>11</label>Institute of Population Health, University of Manchester, Manchester M13 9PL, UK</aff><aff id="aff12"><label>12</label>Ministry of Public Health, Nonthaburi 11000, Thailand</aff><aff id="aff13"><label>13</label>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</aff><aff id="aff14"><label>14</label>Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA</aff><aff id="aff15"><label>15</label>Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany</aff><aff id="aff16"><label>16</label>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</aff><aff id="aff17"><label>17</label>Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK</aff><aff id="aff18"><label>18</label>Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London SE1 9RT, UK</aff><aff id="aff19"><label>19</label>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford OX3 7BN, UK</aff><aff id="aff20"><label>20</label>Clinical Science Institute, University Hospital Galway, Galway, Ireland</aff><aff id="aff21"><label>21</label>Department of Obstetrics and Gynecology, University of Heidelberg, 69115 Heidelberg, Germany</aff><aff id="aff22"><label>22</label>National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany</aff><aff id="aff23"><label>23</label>Molecular Genetics of Breast Cancer, German Cancer Research Center, 69120 Heidelberg, Germany</aff><aff id="aff24"><label>24</label>Institut National de la Santé et de la Recherche Médicale U1018, Environmental Epidemiology of Cancers, Centre de Recherche en Epidémiologie et Santé des Populations, 94807 Villejuif, France</aff><aff id="aff25"><label>25</label>UMRS 1018, University Paris-Sud, 94807 Villejuif, France</aff><aff id="aff26"><label>26</label>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</aff><aff id="aff27"><label>27</label>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</aff><aff id="aff28"><label>28</label>Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark</aff><aff id="aff29"><label>29</label>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark</aff><aff id="aff30"><label>30</label>Centro Nacional de Genotipado Human Genotyping Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain</aff><aff id="aff31"><label>31</label>Centro de Investigación en Red de Enfermedades Raras, 46010 Valencia, Spain</aff><aff id="aff32"><label>32</label>Human Genetics Group, Spanish National Cancer Centre and Biomedical Network on Rare Diseases, 28029 Madrid, Spain</aff><aff id="aff33"><label>33</label>Servicio de Oncología Médica, Hospital Universitario La Paz, 28029 Madrid, Spain</aff><aff id="aff34"><label>34</label>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, 33012 Oviedo, Spain</aff><aff id="aff35"><label>35</label>Department of Epidemiology, University of California, Irvine, Irvine, CA 92697, USA</aff><aff id="aff36"><label>36</label>Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</aff><aff id="aff37"><label>37</label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, 69120 Heidelberg, Germany</aff><aff id="aff38"><label>38</label>German Cancer Consortium, 69120 Heidelberg, Germany</aff><aff id="aff39"><label>39</label>Saarland Cancer Registry, 66024 Saarbrücken, Germany</aff><aff id="aff40"><label>40</label>Division of Gynaecology and Obstetrics, Technische Universität München, 81675 Munich, Germany</aff><aff id="aff41"><label>41</label>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, 50931 Cologne, Germany</aff><aff id="aff42"><label>42</label>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology, Center for Molecular Medicine Cologne, University Hospital of Cologne, 50937 Cologne, Germany</aff><aff id="aff43"><label>43</label>Center for Molecular Medicine Cologne, University of Cologne, 50923 Cologne, Germany</aff><aff id="aff44"><label>44</label>Center for Integrated Oncology, Medical Faculty, University Hospital of Cologne, 50937 Cologne, Germany</aff><aff id="aff45"><label>45</label>University of Tübingen, 72074 Tübingen, Germany</aff><aff id="aff46"><label>46</label>Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, 70376 Stuttgart, Germany</aff><aff id="aff47"><label>47</label>Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, 53113 Bonn, Germany</aff><aff id="aff48"><label>48</label>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, 44789 Bochum, Germany</aff><aff id="aff49"><label>49</label>Institute of Occupational Medicine and Maritime Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany</aff><aff id="aff50"><label>50</label>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, 00029 Helsinki, Finland</aff><aff id="aff51"><label>51</label>Department of Clinical Genetics, Helsinki University Central Hospital, 00029 Helsinki, Finland</aff><aff id="aff52"><label>52</label>Department of Oncology, University of Helsinki and Helsinki University Central Hospital, 00029 Helsinki, Finland</aff><aff id="aff53"><label>53</label>Department of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan</aff><aff id="aff54"><label>54</label>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan</aff><aff id="aff55"><label>55</label>Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan</aff><aff id="aff56"><label>56</label>Gynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany</aff><aff id="aff57"><label>57</label>Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany</aff><aff id="aff58"><label>58</label>Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 77 Stockholm, Sweden</aff><aff id="aff59"><label>59</label>Department of Oncology-Pathology, Karolinska Institutet, 171 77 Stockholm, Sweden</aff><aff id="aff60"><label>60</label>Cancer Center of Eastern Finland, University of Eastern Finland, 70211 Kuopio, Finland</aff><aff id="aff61"><label>61</label>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland</aff><aff id="aff62"><label>62</label>School of Medicine, Institute of Clinical Medicine, Pathology, and Forensic Medicine, University of Eastern Finland, 70211 Kuopio, Finland</aff><aff id="aff63"><label>63</label>Cancer Center, Kuopio University Hospital, 70211 Kuopio, Finland</aff><aff id="aff64"><label>64</label>Peter MacCallum Cancer Institute, East Melbourne, VIC 3002, Australia</aff><aff id="aff65"><label>65</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA</aff><aff id="aff66"><label>66</label>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, 3000 Leuven, Belgium</aff><aff id="aff67"><label>67</label>Vesalius Research Center, VIB, 3000 Leuven, Belgium</aff><aff id="aff68"><label>68</label>University Hospital Gashuisberg, 3000 Leuven, Belgium</aff><aff id="aff69"><label>69</label>Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany</aff><aff id="aff70"><label>70</label>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, 20246 Hamburg, Germany</aff><aff id="aff71"><label>71</label>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Istituto Nazionale Tumori, Fondazione Istituto Neurologico Carlo Besta, 20133 Milan, Italy</aff><aff id="aff72"><label>72</label>Istituto Fondazione Italiana per la Ricerca sul Cancro di Oncologia Molecolare, 20139 Milan, Italy</aff><aff id="aff73"><label>73</label>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, 20141 Milan, Italy</aff><aff id="aff74"><label>74</label>Cogentech Cancer Genetic Test Laboratory, 20139 Milan, Italy</aff><aff id="aff75"><label>75</label>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</aff><aff id="aff76"><label>76</label>Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</aff><aff id="aff77"><label>77</label>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia</aff><aff id="aff78"><label>78</label>Anatomical Pathology, The Alfred, Melbourne, VIC 3004, Australia</aff><aff id="aff79"><label>79</label>University of Hawaii Cancer Centre Honolulu, HI 96813, USA</aff><aff id="aff80"><label>80</label>Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, QC G1V 4G2, Canada</aff><aff id="aff81"><label>81</label>Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC H3A 1A1, Canada</aff><aff id="aff82"><label>82</label>Department of Medicine, McGill University, Montreal, QC H3A 1A1, Canada</aff><aff id="aff83"><label>83</label>Département de Médecine Sociale et Préventive, Département de Santé Environnementale et Santé au Travail, Université de Montréal, Montreal, QC H3A 3C2, Canada</aff><aff id="aff84"><label>84</label>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 47500 Subang Jaya, Malaysia</aff><aff id="aff85"><label>85</label>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia</aff><aff id="aff86"><label>86</label>Singapore Eye Research Institute, National University of Singapore, Singapore 168751, Singapore</aff><aff id="aff87"><label>87</label>Institute of Clinical Medicine, University of Oslo, 0450 Oslo, Norway</aff><aff id="aff88"><label>88</label>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</aff><aff id="aff89"><label>89</label>Department of Clinical Molecular Biology, University of Oslo, 0450 Oslo, Norway</aff><aff id="aff90"><label>90</label>Section of Oncology, Institute of Medicine, University of Bergen, 5020 Bergen, Norway</aff><aff id="aff91"><label>91</label>Norwegian Centre for Integrated Care and Telemedicine, University Hospital of North Norway, 9038 Tromsø, Norway</aff><aff id="aff92"><label>92</label>National Resource Centre for Long-Term Studies after Cancer, Rikshospitalet-Radiumhospitalet Cancer Clinic, Montebello, 0310 Oslo, Norway</aff><aff id="aff93"><label>93</label>Division of Cancer Medicine and Radiotherapy, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</aff><aff id="aff94"><label>94</label>Department of Surgery, Akershus University Hospital, 1478 Lørenskog, Norway</aff><aff id="aff95"><label>95</label>Department of Radiology, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</aff><aff id="aff96"><label>96</label>Department of Pathology, Akershus University Hospital, 1478 Lørenskog, Norway</aff><aff id="aff97"><label>97</label>Department of Oncology, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</aff><aff id="aff98"><label>98</label>Department of Oncology, Haukeland University Hospital, Bergen, 5021 Bergen, Norway</aff><aff id="aff99"><label>99</label>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø – The Arctic University of Norway, 9019 Tromsø, Norway</aff><aff id="aff100"><label>100</label>Department of Clinical Molecular Biology, Institute of Clinical Medicine, Akershus University Hospital, University of Oslo, 1478 Lørenskog, Norway</aff><aff id="aff101"><label>101</label>Department of Breast and Endocrine Surgery, Institute for Clinical Medicine, Ullevaal University Hospital, Oslo University Hospital, 0450 Oslo, Norway</aff><aff id="aff102"><label>102</label>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</aff><aff id="aff103"><label>103</label>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu, Oulu University Hospital, 90210 Oulu, Finland</aff><aff id="aff104"><label>104</label>Department of Oncology, Oulu University Hospital, University of Oulu, 90014 Oulu, Finland</aff><aff id="aff105"><label>105</label>Department of Pathology, Oulu University Hospital, University of Oulu, 90014 Oulu, Finland</aff><aff id="aff106"><label>106</label>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</aff><aff id="aff107"><label>107</label>Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1X5, Canada</aff><aff id="aff108"><label>108</label>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada</aff><aff id="aff109"><label>109</label>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</aff><aff id="aff110"><label>110</label>Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</aff><aff id="aff111"><label>111</label>Departments of Human Genetics and Pathology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands</aff><aff id="aff112"><label>112</label>Family Cancer Clinic, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands</aff><aff id="aff113"><label>113</label>Department of Clinical Genetics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands</aff><aff id="aff114"><label>114</label>Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK</aff><aff id="aff115"><label>115</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA</aff><aff id="aff116"><label>116</label>Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland</aff><aff id="aff117"><label>117</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden</aff><aff id="aff118"><label>118</label>Department of Medical Oncology, Erasmus University Medical Center Cancer Institute, 3075 EA Rotterdam, the Netherlands</aff><aff id="aff119"><label>119</label>Department of Clinical Genetics, Erasmus University Medical Center, 3008 AE Rotterdam, the Netherlands</aff><aff id="aff120"><label>120</label>Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore</aff><aff id="aff121"><label>121</label>Shanghai Center for Disease Control and Prevention, Changning, Shanghai 200336, China</aff><aff id="aff122"><label>122</label>Department of Epidemiology, Shanghai Cancer Institute, Shanghai 200032, China</aff><aff id="aff123"><label>123</label>Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK</aff><aff id="aff124"><label>124</label>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2RX, UK</aff><aff id="aff125"><label>125</label>International Epidemiology Institute, Rockville, MD 20850, USA</aff><aff id="aff126"><label>126</label>Department of Preventive Medicine, Seoul National University College of Medicine and Cancer Research Institute, Seoul National University, Seoul 110-799, Korea</aff><aff id="aff127"><label>127</label>Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 151-742, Korea</aff><aff id="aff128"><label>128</label>Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea</aff><aff id="aff129"><label>129</label>Department of Surgery, Seoul National University, Bundang Hospital, Seongnam 110-744, Korea</aff><aff id="aff130"><label>130</label>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore</aff><aff id="aff131"><label>131</label>Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore 119228, Singapore</aff><aff id="aff132"><label>132</label>Division of General Surgery, National University Health System, Singapore 119228, Singapore</aff><aff id="aff133"><label>133</label>Institute of Human Genetics, Pontificia Universidad Javeriana, Bogotá 11001000, Colombia</aff><aff id="aff134"><label>134</label>Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland</aff><aff id="aff135"><label>135</label>National Cancer Institute, Bangkok 10400, Thailand</aff><aff id="aff136"><label>136</label>International Agency for Research on Cancer, 69372 Lyon, France</aff><aff id="aff137"><label>137</label>Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA</aff><aff id="aff138"><label>138</label>Molecular Diagnostics Laboratory, Institute of Radioisotopes and Radiodiagnostic Products, National Centre for Scientific Research “Demokritos,” Aghia Paraskevi Attikis, Athens 15310, Greece</aff><aff id="aff139"><label>139</label>Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</aff><aff id="aff140"><label>140</label>School of Public Health, China Medical University, Taichung 40402, Taiwan</aff><aff id="aff141"><label>141</label>Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</aff><aff id="aff142"><label>142</label>Department of Surgery, Tri-Service General Hospital, Taipei 114, Taiwan</aff><aff id="aff143"><label>143</label>Cancer Center and Department of Surgery, Kaohsiung Medical University, Chung-Ho Memorial Hospital, Kaohsiung 807, Taiwan</aff><aff id="aff144"><label>144</label>Division of Breast Cancer Research, Institute of Cancer Research, Sutton SM2 5NG, UK</aff><aff id="aff145"><label>145</label>McGill University and Génome Québec Innovation Centre, Montreal, QC H3A 0G1, Canada</aff><author-notes><corresp id="cor1"><label>∗</label>Corresponding author <email>amd24@medschl.cam.ac.uk</email></corresp><corresp id="cor2"><label>∗∗</label>Corresponding author <email>juliet.french@qimrberghofer.edu.au</email></corresp><fn id="fn1"><label>146</label><p>On behalf of the German Consortium of Hereditary Breast and Ovarian Cancer</p></fn><fn id="fn2"><label>147</label><p>These authors contributed equally to this work</p></fn><fn id="fn3"><label>148</label><p>These authors contributed equally to this work</p></fn></author-notes><pub-date pub-type="pmc-release"><day>08</day><month>1</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>08</day><month>1</month><year>2015</year></pub-date><volume>96</volume><issue>1</issue><fpage>5</fpage><lpage>20</lpage><history><date date-type="received"><day>9</day><month>7</month><year>2014</year></date><date date-type="accepted"><day>17</day><month>11</month><year>2014</year></date></history><permissions><copyright-statement>© 2015 The American Society of Human Genetics. Published by Elsevier Ltd. All right reserved.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>The American Society of Human Genetics</copyright-holder></permissions><abstract><p>Genome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an attempt to identify the biologically relevant variants, we analyzed 909 genetic variants across 5q11.2 in 103,991 breast cancer individuals and control individuals from 52 studies in the Breast Cancer Association Consortium. Multiple logistic regression analyses identified three independent risk signals: the strongest associations were with 15 correlated variants (iCHAV1), where the minor allele of the best candidate, rs62355902, associated with significantly increased risks of both estrogen-receptor-positive (ER<sup>+</sup>: odds ratio [OR] = 1.24, 95% confidence interval [CI] = 1.21–1.27, p<sub>trend</sub> = 5.7 × 10<sup>−44</sup>) and estrogen-receptor-negative (ER<sup>−</sup>: OR = 1.10, 95% CI = 1.05–1.15, p<sub>trend</sub> = 3.0 × 10<sup>−4</sup>) tumors. After adjustment for rs62355902, we found evidence of association of a further 173 variants (iCHAV2) containing three subsets with a range of effects (the strongest was rs113317823 [p<sub>cond</sub> = 1.61 × 10<sup>−5</sup>]) and five variants composing iCHAV3 (lead rs11949391; ER<sup>+</sup>: OR = 0.90, 95% CI = 0.87–0.93, p<sub>cond</sub> = 1.4 × 10<sup>−4</sup>). Twenty-six percent of the prioritized candidate variants coincided with four putative regulatory elements that interact with the <italic>MAP3K1</italic> promoter through chromatin looping and affect <italic>MAP3K1</italic> promoter activity. Functional analysis indicated that the cancer risk alleles of four candidates (rs74345699 and rs62355900 [iCHAV1], rs16886397 [iCHAV2a], and rs17432750 [iCHAV3]) increased <italic>MAP3K1</italic> transcriptional activity. Chromatin immunoprecipitation analysis revealed diminished GATA3 binding to the minor (cancer-protective) allele of rs17432750, indicating a mechanism for its action. We propose that the cancer risk alleles act to increase <italic>MAP3K1</italic> expression in vivo and might promote breast cancer cell survival.</p></abstract></article-meta><notes><p id="misc0010">Published: December 18, 2014</p></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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