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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus: Putative Functional Variants Differentially Bind FOXA1 and E2F1</title><author><name sortKey="Meyer, Kerstin B" sort="Meyer, Kerstin B" uniqKey="Meyer K" first="Kerstin B." last="Meyer">Kerstin B. Meyer</name><affiliation><nlm:aff id="aff1">CRUK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Martin" sort="O Eilly, Martin" uniqKey="O Eilly M" first="Martin" last="O Eilly">Martin O Eilly</name><affiliation><nlm:aff id="aff1">CRUK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Carlebur, Saskia" sort="Carlebur, Saskia" uniqKey="Carlebur S" first="Saskia" last="Carlebur">Saskia Carlebur</name><affiliation><nlm:aff id="aff1">CRUK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Edwards, Stacey L" sort="Edwards, Stacey L" uniqKey="Edwards S" first="Stacey L." last="Edwards">Stacey L. Edwards</name><affiliation><nlm:aff id="aff3">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia</nlm:aff></affiliation></author><author><name sortKey="French, Juliet D" sort="French, Juliet D" uniqKey="French J" first="Juliet D." last="French">Juliet D. French</name><affiliation><nlm:aff id="aff3">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia</nlm:aff></affiliation></author><author><name sortKey="Prathalingham, Radhika" sort="Prathalingham, Radhika" uniqKey="Prathalingham R" first="Radhika" last="Prathalingham">Radhika Prathalingham</name><affiliation><nlm:aff id="aff1">CRUK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="De Santiago, Ines" sort="De Santiago, Ines" uniqKey="De Santiago I" first="Ines" last="De Santiago">Ines De Santiago</name><affiliation><nlm:aff id="aff1">CRUK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="aff5">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation><nlm:aff id="aff6">Department of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="aff5">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="aff6">Department of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="aff7">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="aff7">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Veer, Laura J" sort="Van Veer, Laura J" uniqKey="Van Veer L" first="Laura J." last="Van Veer">Laura J. Van Veer</name><affiliation><nlm:aff id="aff7">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans B" sort="Hogervorst, Frans B" uniqKey="Hogervorst F" first="Frans B." last="Hogervorst">Frans B. Hogervorst</name><affiliation><nlm:aff id="aff7">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="aff8">Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK and Institute of Population Health, University of Manchester, Manchester M13 9PL, UK</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="aff9">Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK</nlm:aff></affiliation></author><author><name sortKey="Stewart Brown, Sarah" sort="Stewart Brown, Sarah" uniqKey="Stewart Brown S" first="Sarah" last="Stewart-Brown">Sarah Stewart-Brown</name><affiliation><nlm:aff id="aff9">Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK</nlm:aff></affiliation></author><author><name sortKey="Siriwanarangsan, Pornthep" sort="Siriwanarangsan, Pornthep" uniqKey="Siriwanarangsan P" first="Pornthep" last="Siriwanarangsan">Pornthep Siriwanarangsan</name><affiliation><nlm:aff id="aff10">Ministry of Public Health, Bangkok 10400, Thailand</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="aff11">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff12">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA 90095, USA</nlm:aff></affiliation></author><author><name sortKey="Lux, Michael P" sort="Lux, Michael P" uniqKey="Lux M" first="Michael P." last="Lux">Michael P. Lux</name><affiliation><nlm:aff id="aff11">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="aff12">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA 90095, USA</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="aff12">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA 90095, USA</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="aff13">London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos Santos Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="aff13">London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="aff14">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="aff14">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="aff15">Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, London SE1 9RT, UK</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="aff16">Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name><affiliation><nlm:aff id="aff17">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="aff17">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Marme, Federick" sort="Marme, Federick" uniqKey="Marme F" first="Federick" last="Marme">Federick Marme</name><affiliation><nlm:aff id="aff18">Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff19">National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation><nlm:aff id="aff18">Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff19">National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><affiliation><nlm:aff id="aff18">Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="aff18">Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff20">Molecular Epidemiology Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="aff21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population) and University Paris-Sud, UMRS 1018, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="aff21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population) and University Paris-Sud, UMRS 1018, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Laurent Puig, Pierre" sort="Laurent Puig, Pierre" uniqKey="Laurent Puig P" first="Pierre" last="Laurent-Puig">Pierre Laurent-Puig</name><affiliation><nlm:aff id="aff22">Université Paris Sorbonne Cité, UMR-S775 Inserm, 75270 Paris Cedex 06, France</nlm:aff></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation><nlm:aff id="aff21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population) and University Paris-Sud, UMRS 1018, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="aff23">Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, 2730 Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="aff23">Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, 2730 Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="aff23">Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, 2730 Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="aff24">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, 2730 Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="aff25">Genetic & Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="aff26">Servicio de Oncología Médica, Hospital Universitario La Paz, 28046 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Arias, Jose I" sort="Arias, Jose I" uniqKey="Arias J" first="Jose I." last="Arias">Jose I. Arias</name><affiliation><nlm:aff id="aff27">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, 33012 Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="aff28">Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain and Centro de Investigación en Red de Enfermedades Raras (CIBERER), 46010 Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan" sort="Neuhausen, Susan" uniqKey="Neuhausen S" first="Susan" last="Neuhausen">Susan Neuhausen</name><affiliation><nlm:aff id="aff29">Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="aff30">Department of Epidemiology, University of California, Irvine, Irvine, CA 92697, USA</nlm:aff></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation><nlm:aff id="aff30">Department of Epidemiology, University of California, Irvine, Irvine, CA 92697, USA</nlm:aff></affiliation></author><author><name sortKey="Dur, Christina C" sort="Dur, Christina C" uniqKey="Dur C" first="Christina C." last="Dur">Christina C. Dur</name><affiliation><nlm:aff id="aff31">Cancer Prevention Institute of California, Fremont, CA 94538, USA</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="aff32">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name><affiliation><nlm:aff id="aff32">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="aff32">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="aff33">Saarland Cancer Registry, 66024 Saarbrücken, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="aff34">Division of Gynaecology and Obstetrics, Technische Universität München, 81675 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="aff35">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics at the University Cologne, 50931 Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation><nlm:aff id="aff36">Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Ditsch, Nina" sort="Ditsch, Nina" uniqKey="Ditsch N" first="Nina" last="Ditsch">Nina Ditsch</name><affiliation><nlm:aff id="aff37">Department of Gynaecology and Obstetrics, Ludwig-Maximilians-Universität, 80539 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="aff38">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany and University of Tübingen, 72074 Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="aff39">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), 44789 Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation><nlm:aff id="aff40">Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, 53113 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="aff41">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="aff41">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="aff42">Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="aff43">Department of Oncology, Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:aff id="aff44">Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka 812-8582, Japan</nlm:aff></affiliation></author><author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name><affiliation><nlm:aff id="aff45">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan</nlm:aff></affiliation></author><author><name sortKey="Iwata, Hiroji" sort="Iwata, Hiroji" uniqKey="Iwata H" first="Hiroji" last="Iwata">Hiroji Iwata</name><affiliation><nlm:aff id="aff46">Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan</nlm:aff></affiliation></author><author><name sortKey="Yatabe, Yasushi" sort="Yatabe, Yasushi" uniqKey="Yatabe Y" first="Yasushi" last="Yatabe">Yasushi Yatabe</name><affiliation><nlm:aff id="aff47">Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="aff48">Department of Obstetrics and Gynaecology, Hannover Medical School, 30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Helbig, Sonja" sort="Helbig, Sonja" uniqKey="Helbig S" first="Sonja" last="Helbig">Sonja Helbig</name><affiliation><nlm:aff id="aff48">Department of Obstetrics and Gynaecology, Hannover Medical School, 30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="aff49">Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="aff50">Department of Molecular Medicine and Surgery, Karolinska Institutet, 17177 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="aff51">Department of Oncology-Pathology, Karolinska Institutet, 17177 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="aff52">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland and University of Eastern Finland, and Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="aff53">School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland and Cancer Center, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="aff52">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland and University of Eastern Finland, and Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="aff52">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland and University of Eastern Finland, and Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="aff3">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H." last="Wu">Anna H. Wu</name><affiliation><nlm:aff id="aff54">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name><affiliation><nlm:aff id="aff54">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, David" sort="Van Den Berg, David" uniqKey="Van Den Berg D" first="David" last="Van Den Berg">David Van Den Berg</name><affiliation><nlm:aff id="aff54">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name><affiliation><nlm:aff id="aff54">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="aff55">Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="aff56">Department of Oncology, University of Leuven, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Thienpont, Bernard" sort="Thienpont, Bernard" uniqKey="Thienpont B" first="Bernard" last="Thienpont">Bernard Thienpont</name><affiliation><nlm:aff id="aff55">Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="aff56">Department of Oncology, University of Leuven, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Christiaens, Marie Rose" sort="Christiaens, Marie Rose" uniqKey="Christiaens M" first="Marie-Rose" last="Christiaens">Marie-Rose Christiaens</name><affiliation><nlm:aff id="aff57">Oncology Department, University Hospital Gasthuisberg, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Smeets, Ann" sort="Smeets, Ann" uniqKey="Smeets A" first="Ann" last="Smeets">Ann Smeets</name><affiliation><nlm:aff id="aff58">Universital Hospital Gasthuisberg, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="aff59">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="aff59">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Seibold, Petra" sort="Seibold, Petra" uniqKey="Seibold P" first="Petra" last="Seibold">Petra Seibold</name><affiliation><nlm:aff id="aff59">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="aff60">Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, 20246 Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="aff61">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="aff62">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, 20139 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation><nlm:aff id="aff63">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), 20141 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bernard, Loris" sort="Bernard, Loris" uniqKey="Bernard L" first="Loris" last="Bernard">Loris Bernard</name><affiliation><nlm:aff id="aff64">Department of Experimental Oncology, Istituto Europeo di Oncologia (IEO), 20141 Milan, Italy and Cogentech Cancer Genetic Test Laboratory, 20139 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="aff65">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="aff66">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="aff65">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Purrington, Kristen" sort="Purrington, Kristen" uniqKey="Purrington K" first="Kristen" last="Purrington">Kristen Purrington</name><affiliation><nlm:aff id="aff67">Karmanos Cancer Center, Detroit, MI 48201, USA</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="aff5">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff68">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="aff5">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff68">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="aff68">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="aff69">Anatomical Pathology, The Alfred Hospital, Melbourne, VIC 3181, Australia</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="aff54">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="aff54">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation><nlm:aff id="aff54">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="aff70">Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="aff71">Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, QC G1V 4G2, Canada</nlm:aff></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name><affiliation><nlm:aff id="aff72">Department of Medicine, McGill University, Montreal, QC H3A 1A1, Canada and Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC H3A 1A1, Canada</nlm:aff></affiliation></author><author><name sortKey="Labreche, France" sort="Labreche, France" uniqKey="Labreche F" first="France" last="Labrèche">France Labrèche</name><affiliation><nlm:aff id="aff73">Département de médecine sociale et préventive, Département de santé environnementale et santé au travail, Université de Montréal, Montreal, QC H3A 3C2, Canada</nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="aff71">Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, QC G1V 4G2, Canada</nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo-Hwang" last="Teo">Soo-Hwang Teo</name><affiliation><nlm:aff id="aff74">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, 47500 Selangor, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="aff75">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng-Har" last="Yip">Cheng-Har Yip</name><affiliation><nlm:aff id="aff75">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Phuah, Sze Yee" sort="Phuah, Sze Yee" uniqKey="Phuah S" first="Sze-Yee" last="Phuah">Sze-Yee Phuah</name><affiliation><nlm:aff id="aff74">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, 47500 Selangor, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="aff75">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="aff76">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="aff77">Faculty of Medicine (Faculty Division Ahus), University of Oslo (UiO), 0318 Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Grenaker Aln S, Grethe" sort="Grenaker Aln S, Grethe" uniqKey="Grenaker Aln S G" first="Grethe" last="Grenaker Aln S">Grethe Grenaker Aln S</name><affiliation><nlm:aff id="aff76">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name><affiliation><nlm:aff id="aff76">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="aff77">Faculty of Medicine (Faculty Division Ahus), University of Oslo (UiO), 0318 Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Deming Halverson, Sandra" sort="Deming Halverson, Sandra" uniqKey="Deming Halverson S" first="Sandra" last="Deming-Halverson">Sandra Deming-Halverson</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Martha" sort="Shrubsole, Martha" uniqKey="Shrubsole M" first="Martha" last="Shrubsole">Martha Shrubsole</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="aff79">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="aff79">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="aff80">Department of Oncology, Oulu University Hospital, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kauppila, Saila" sort="Kauppila, Saila" uniqKey="Kauppila S" first="Saila" last="Kauppila">Saila Kauppila</name><affiliation><nlm:aff id="aff80">Department of Oncology, Oulu University Hospital, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="aff81">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="aff82">Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="aff81">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="aff83">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 1A8, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="aff81">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name><affiliation><nlm:aff id="aff81">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="aff84">Department of Human Genetics & Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="aff85">Department of Surgical Oncology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline M" sort="Seynaeve, Caroline M" uniqKey="Seynaeve C" first="Caroline M." last="Seynaeve">Caroline M. Seynaeve</name><affiliation><nlm:aff id="aff86">Department of Medical Oncology, Erasmus MC Cancer Institute, 3075 EA Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="aff14">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff87">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="aff88">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="aff88">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="aff89">Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw 02-781, Poland</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="aff90">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hartef" sort="Darabi, Hartef" uniqKey="Darabi H" first="Hartef" last="Darabi">Hartef Darabi</name><affiliation><nlm:aff id="aff90">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Kimael" sort="Eriksson, Kimael" uniqKey="Eriksson K" first="Kimael" last="Eriksson">Kimael Eriksson</name><affiliation><nlm:aff id="aff90">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="aff86">Department of Medical Oncology, Erasmus MC Cancer Institute, 3075 EA Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation><nlm:aff id="aff86">Department of Medical Oncology, Erasmus MC Cancer Institute, 3075 EA Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name><affiliation><nlm:aff id="aff91">Department of Clinical Genetics, Erasmus University Medical Center, 3008 AE Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H. M." last="Van Deurzen">Carolien H. M. Van Deurzen</name><affiliation><nlm:aff id="aff92">Department of Pathology, Erasmus University Medical Center, 3008 AE Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="aff90">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="aff93">Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="aff93">Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="aff90">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Lu, Wei" sort="Lu, Wei" uniqKey="Lu W" first="Wei" last="Lu">Wei Lu</name><affiliation><nlm:aff id="aff94">Shanghai Center for Disease Control and Prevention, Shanghai 200336, China</nlm:aff></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation><nlm:aff id="aff95">Department of Epidemiology, Shanghai Cancer Institute, Shanghai 200032, China</nlm:aff></affiliation></author><author><name sortKey="Cai, Hui" sort="Cai, Hui" uniqKey="Cai H" first="Hui" last="Cai">Hui Cai</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="aff96">CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, S10 2RX, UK</nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="aff96">CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, S10 2RX, UK</nlm:aff></affiliation></author><author><name sortKey="Blot, William" sort="Blot, William" uniqKey="Blot W" first="William" last="Blot">William Blot</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation><affiliation><nlm:aff id="aff96">CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, S10 2RX, UK</nlm:aff></affiliation></author><author><name sortKey="Signorello, Lisa B" sort="Signorello, Lisa B" uniqKey="Signorello L" first="Lisa B." last="Signorello">Lisa B. Signorello</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation><affiliation><nlm:aff id="aff97">International Epidemiology Institute, Rockville, MD 20850, USA</nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Harrington, Patricia" sort="Harrington, Patricia" uniqKey="Harrington P" first="Patricia" last="Harrington">Patricia Harrington</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Tyrer, Jonathan" sort="Tyrer, Jonathan" uniqKey="Tyrer J" first="Jonathan" last="Tyrer">Jonathan Tyrer</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="aff98">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="aff99">Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 110-799, Korea</nlm:aff></affiliation></author><author><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name><affiliation><nlm:aff id="aff99">Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 110-799, Korea</nlm:aff></affiliation></author><author><name sortKey="Park, Sue K" sort="Park, Sue K" uniqKey="Park S" first="Sue K." last="Park">Sue K. Park</name><affiliation><nlm:aff id="aff98">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation></author><author><name sortKey="Noh, Dong Young" sort="Noh, Dong Young" uniqKey="Noh D" first="Dong-Young" last="Noh">Dong-Young Noh</name><affiliation><nlm:aff id="aff100">Department of Surgery, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation><nlm:aff id="aff101">Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore and National University Health System, Singapore 119228, Singapore</nlm:aff></affiliation></author><author><name sortKey="Hui, Miao" sort="Hui, Miao" uniqKey="Hui M" first="Miao" last="Hui">Miao Hui</name><affiliation><nlm:aff id="aff101">Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore and National University Health System, Singapore 119228, Singapore</nlm:aff></affiliation></author><author><name sortKey="Lim, Wei Yen" sort="Lim, Wei Yen" uniqKey="Lim W" first="Wei-Yen" last="Lim">Wei-Yen Lim</name><affiliation><nlm:aff id="aff101">Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore and National University Health System, Singapore 119228, Singapore</nlm:aff></affiliation></author><author><name sortKey="Buhari, Shaik A" sort="Buhari, Shaik A" uniqKey="Buhari S" first="Shaik A." last="Buhari">Shaik A. Buhari</name><affiliation><nlm:aff id="aff102">Division of General Surgery, National University Health System, Singapore 119228</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="aff103">Molecular Genetics of Breast Cancer, German Cancer Research Centre (DKFZ), 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Forsti, Asta" sort="Forsti, Asta" uniqKey="Forsti A" first="Asta" last="Försti">Asta Försti</name><affiliation><nlm:aff id="aff104">Center for Primary Health Care Research, Clinical Research Centre (CRC), Skanes universitetssjukhus, 20502 Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Rudiger, Thomas" sort="Rudiger, Thomas" uniqKey="Rudiger T" first="Thomas" last="Rüdiger">Thomas Rüdiger</name><affiliation><nlm:aff id="aff105">Institute of Pathology, Städtisches Klinikum Karlsruhe, 76133 Karlsruhe, Germany</nlm:aff></affiliation></author><author><name sortKey="Ulmer, Hans Ulrich" sort="Ulmer, Hans Ulrich" uniqKey="Ulmer H" first="Hans-Ulrich" last="Ulmer">Hans-Ulrich Ulmer</name><affiliation><nlm:aff id="aff106">Frauenklinik der Stadtklinik Baden-Baden, 76532 Baden-Baden, Germany</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="aff107">Department of Genetics and Pathology, Pomeranian Medical University, u. Polabska 4, 70-115 Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="aff107">Department of Genetics and Pathology, Pomeranian Medical University, u. Polabska 4, 70-115 Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="aff107">Department of Genetics and Pathology, Pomeranian Medical University, u. Polabska 4, 70-115 Szczecin, Poland</nlm:aff></affiliation><affiliation><nlm:aff id="aff108">Postgraduate School of Molecular Medicine, Warsaw Medical University, ul. Żwirki i Wigury 61, 02-091 Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="aff107">Department of Genetics and Pathology, Pomeranian Medical University, u. Polabska 4, 70-115 Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="aff109">National Cancer Institute, Bangkok 10400, Thailand</nlm:aff></affiliation></author><author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name><affiliation><nlm:aff id="aff110">International Agency for Research on Cancer, 69372 Lyon Cedex 08, France</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="aff110">International Agency for Research on Cancer, 69372 Lyon Cedex 08, France</nlm:aff></affiliation></author><author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name><affiliation><nlm:aff id="aff110">International Agency for Research on Cancer, 69372 Lyon Cedex 08, France</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="aff66">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation><nlm:aff id="aff66">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation><nlm:aff id="aff111">Molecular Diagnostics Laboratory, INRASTES, NSCR Demokritos, Athens 15310, Greece</nlm:aff></affiliation></author><author><name sortKey="Pilarski, Robert" sort="Pilarski, Robert" uniqKey="Pilarski R" first="Robert" last="Pilarski">Robert Pilarski</name><affiliation><nlm:aff id="aff112">Department of Internal Medicine, James Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA</nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="aff113">Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="aff114">Colleague of Public Health, China Medical University, Taichung 40402, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hsiung, Chia Ni" sort="Hsiung, Chia Ni" uniqKey="Hsiung C" first="Chia-Ni" last="Hsiung">Chia-Ni Hsiung</name><affiliation><nlm:aff id="aff113">Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Wu, Pei Ei" sort="Wu, Pei Ei" uniqKey="Wu P" first="Pei-Ei" last="Wu">Pei-Ei Wu</name><affiliation><nlm:aff id="aff114">Colleague of Public Health, China Medical University, Taichung 40402, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hou, Ming Feng" sort="Hou, Ming Feng" uniqKey="Hou M" first="Ming-Feng" last="Hou">Ming-Feng Hou</name><affiliation><nlm:aff id="aff115">Taiwan Biobank and Cancer Center and Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="aff89">Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw 02-781, Poland</nlm:aff></affiliation><affiliation><nlm:aff id="aff116">Division of Breast Cancer Research, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="aff14">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff116">Division of Breast Cancer Research, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="aff14">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff116">Division of Breast Cancer Research, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK</nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J." last="Schoemaker">Minouk J. Schoemaker</name><affiliation><nlm:aff id="aff89">Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw 02-781, Poland</nlm:aff></affiliation></author><author><name sortKey="Ponder, Bruce A J" sort="Ponder, Bruce A J" uniqKey="Ponder B" first="Bruce A. J." last="Ponder">Bruce A. J. Ponder</name><affiliation><nlm:aff id="aff1">CRUK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24290378</idno><idno type="pmc">3852923</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852923</idno><idno type="RBID">PMC:3852923</idno><idno type="doi">10.1016/j.ajhg.2013.10.026</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001686</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001686</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus: Putative Functional Variants Differentially Bind FOXA1 and E2F1</title><author><name sortKey="Meyer, Kerstin B" sort="Meyer, Kerstin B" uniqKey="Meyer K" first="Kerstin B." last="Meyer">Kerstin B. Meyer</name><affiliation><nlm:aff id="aff1">CRUK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Martin" sort="O Eilly, Martin" uniqKey="O Eilly M" first="Martin" last="O Eilly">Martin O Eilly</name><affiliation><nlm:aff id="aff1">CRUK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Carlebur, Saskia" sort="Carlebur, Saskia" uniqKey="Carlebur S" first="Saskia" last="Carlebur">Saskia Carlebur</name><affiliation><nlm:aff id="aff1">CRUK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Edwards, Stacey L" sort="Edwards, Stacey L" uniqKey="Edwards S" first="Stacey L." last="Edwards">Stacey L. Edwards</name><affiliation><nlm:aff id="aff3">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia</nlm:aff></affiliation></author><author><name sortKey="French, Juliet D" sort="French, Juliet D" uniqKey="French J" first="Juliet D." last="French">Juliet D. French</name><affiliation><nlm:aff id="aff3">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia</nlm:aff></affiliation></author><author><name sortKey="Prathalingham, Radhika" sort="Prathalingham, Radhika" uniqKey="Prathalingham R" first="Radhika" last="Prathalingham">Radhika Prathalingham</name><affiliation><nlm:aff id="aff1">CRUK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="De Santiago, Ines" sort="De Santiago, Ines" uniqKey="De Santiago I" first="Ines" last="De Santiago">Ines De Santiago</name><affiliation><nlm:aff id="aff1">CRUK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="aff5">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><affiliation><nlm:aff id="aff6">Department of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="aff5">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="aff6">Department of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="aff7">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="aff7">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Veer, Laura J" sort="Van Veer, Laura J" uniqKey="Van Veer L" first="Laura J." last="Van Veer">Laura J. Van Veer</name><affiliation><nlm:aff id="aff7">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans B" sort="Hogervorst, Frans B" uniqKey="Hogervorst F" first="Frans B." last="Hogervorst">Frans B. Hogervorst</name><affiliation><nlm:aff id="aff7">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="aff8">Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK and Institute of Population Health, University of Manchester, Manchester M13 9PL, UK</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="aff9">Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK</nlm:aff></affiliation></author><author><name sortKey="Stewart Brown, Sarah" sort="Stewart Brown, Sarah" uniqKey="Stewart Brown S" first="Sarah" last="Stewart-Brown">Sarah Stewart-Brown</name><affiliation><nlm:aff id="aff9">Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK</nlm:aff></affiliation></author><author><name sortKey="Siriwanarangsan, Pornthep" sort="Siriwanarangsan, Pornthep" uniqKey="Siriwanarangsan P" first="Pornthep" last="Siriwanarangsan">Pornthep Siriwanarangsan</name><affiliation><nlm:aff id="aff10">Ministry of Public Health, Bangkok 10400, Thailand</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="aff11">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff12">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA 90095, USA</nlm:aff></affiliation></author><author><name sortKey="Lux, Michael P" sort="Lux, Michael P" uniqKey="Lux M" first="Michael P." last="Lux">Michael P. Lux</name><affiliation><nlm:aff id="aff11">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="aff12">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA 90095, USA</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="aff12">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA 90095, USA</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="aff13">London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos Santos Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="aff13">London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="aff14">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="aff14">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="aff15">Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, London SE1 9RT, UK</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="aff16">Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name><affiliation><nlm:aff id="aff17">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="aff17">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Marme, Federick" sort="Marme, Federick" uniqKey="Marme F" first="Federick" last="Marme">Federick Marme</name><affiliation><nlm:aff id="aff18">Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff19">National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation><nlm:aff id="aff18">Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff19">National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><affiliation><nlm:aff id="aff18">Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="aff18">Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff20">Molecular Epidemiology Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="aff21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population) and University Paris-Sud, UMRS 1018, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="aff21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population) and University Paris-Sud, UMRS 1018, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Laurent Puig, Pierre" sort="Laurent Puig, Pierre" uniqKey="Laurent Puig P" first="Pierre" last="Laurent-Puig">Pierre Laurent-Puig</name><affiliation><nlm:aff id="aff22">Université Paris Sorbonne Cité, UMR-S775 Inserm, 75270 Paris Cedex 06, France</nlm:aff></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation><nlm:aff id="aff21">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population) and University Paris-Sud, UMRS 1018, 94807 Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="aff23">Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, 2730 Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="aff23">Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, 2730 Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="aff23">Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, 2730 Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="aff24">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, 2730 Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="aff25">Genetic & Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="aff26">Servicio de Oncología Médica, Hospital Universitario La Paz, 28046 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Arias, Jose I" sort="Arias, Jose I" uniqKey="Arias J" first="Jose I." last="Arias">Jose I. Arias</name><affiliation><nlm:aff id="aff27">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, 33012 Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="aff28">Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain and Centro de Investigación en Red de Enfermedades Raras (CIBERER), 46010 Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan" sort="Neuhausen, Susan" uniqKey="Neuhausen S" first="Susan" last="Neuhausen">Susan Neuhausen</name><affiliation><nlm:aff id="aff29">Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="aff30">Department of Epidemiology, University of California, Irvine, Irvine, CA 92697, USA</nlm:aff></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation><nlm:aff id="aff30">Department of Epidemiology, University of California, Irvine, Irvine, CA 92697, USA</nlm:aff></affiliation></author><author><name sortKey="Dur, Christina C" sort="Dur, Christina C" uniqKey="Dur C" first="Christina C." last="Dur">Christina C. Dur</name><affiliation><nlm:aff id="aff31">Cancer Prevention Institute of California, Fremont, CA 94538, USA</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="aff32">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name><affiliation><nlm:aff id="aff32">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="aff32">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="aff33">Saarland Cancer Registry, 66024 Saarbrücken, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="aff34">Division of Gynaecology and Obstetrics, Technische Universität München, 81675 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="aff35">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics at the University Cologne, 50931 Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation><nlm:aff id="aff36">Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Ditsch, Nina" sort="Ditsch, Nina" uniqKey="Ditsch N" first="Nina" last="Ditsch">Nina Ditsch</name><affiliation><nlm:aff id="aff37">Department of Gynaecology and Obstetrics, Ludwig-Maximilians-Universität, 80539 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="aff38">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany and University of Tübingen, 72074 Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="aff39">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), 44789 Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation><nlm:aff id="aff40">Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, 53113 Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="aff41">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="aff41">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="aff42">Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="aff43">Department of Oncology, Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:aff id="aff44">Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka 812-8582, Japan</nlm:aff></affiliation></author><author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name><affiliation><nlm:aff id="aff45">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan</nlm:aff></affiliation></author><author><name sortKey="Iwata, Hiroji" sort="Iwata, Hiroji" uniqKey="Iwata H" first="Hiroji" last="Iwata">Hiroji Iwata</name><affiliation><nlm:aff id="aff46">Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan</nlm:aff></affiliation></author><author><name sortKey="Yatabe, Yasushi" sort="Yatabe, Yasushi" uniqKey="Yatabe Y" first="Yasushi" last="Yatabe">Yasushi Yatabe</name><affiliation><nlm:aff id="aff47">Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="aff48">Department of Obstetrics and Gynaecology, Hannover Medical School, 30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Helbig, Sonja" sort="Helbig, Sonja" uniqKey="Helbig S" first="Sonja" last="Helbig">Sonja Helbig</name><affiliation><nlm:aff id="aff48">Department of Obstetrics and Gynaecology, Hannover Medical School, 30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="aff49">Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="aff50">Department of Molecular Medicine and Surgery, Karolinska Institutet, 17177 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="aff51">Department of Oncology-Pathology, Karolinska Institutet, 17177 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="aff52">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland and University of Eastern Finland, and Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="aff53">School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland and Cancer Center, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="aff52">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland and University of Eastern Finland, and Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="aff52">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland and University of Eastern Finland, and Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="aff3">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H." last="Wu">Anna H. Wu</name><affiliation><nlm:aff id="aff54">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name><affiliation><nlm:aff id="aff54">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, David" sort="Van Den Berg, David" uniqKey="Van Den Berg D" first="David" last="Van Den Berg">David Van Den Berg</name><affiliation><nlm:aff id="aff54">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name><affiliation><nlm:aff id="aff54">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="aff55">Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="aff56">Department of Oncology, University of Leuven, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Thienpont, Bernard" sort="Thienpont, Bernard" uniqKey="Thienpont B" first="Bernard" last="Thienpont">Bernard Thienpont</name><affiliation><nlm:aff id="aff55">Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="aff56">Department of Oncology, University of Leuven, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Christiaens, Marie Rose" sort="Christiaens, Marie Rose" uniqKey="Christiaens M" first="Marie-Rose" last="Christiaens">Marie-Rose Christiaens</name><affiliation><nlm:aff id="aff57">Oncology Department, University Hospital Gasthuisberg, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Smeets, Ann" sort="Smeets, Ann" uniqKey="Smeets A" first="Ann" last="Smeets">Ann Smeets</name><affiliation><nlm:aff id="aff58">Universital Hospital Gasthuisberg, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="aff59">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="aff59">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Seibold, Petra" sort="Seibold, Petra" uniqKey="Seibold P" first="Petra" last="Seibold">Petra Seibold</name><affiliation><nlm:aff id="aff59">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="aff60">Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, 20246 Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="aff61">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="aff62">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, 20139 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation><nlm:aff id="aff63">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), 20141 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bernard, Loris" sort="Bernard, Loris" uniqKey="Bernard L" first="Loris" last="Bernard">Loris Bernard</name><affiliation><nlm:aff id="aff64">Department of Experimental Oncology, Istituto Europeo di Oncologia (IEO), 20141 Milan, Italy and Cogentech Cancer Genetic Test Laboratory, 20139 Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="aff65">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="aff66">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="aff65">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Purrington, Kristen" sort="Purrington, Kristen" uniqKey="Purrington K" first="Kristen" last="Purrington">Kristen Purrington</name><affiliation><nlm:aff id="aff67">Karmanos Cancer Center, Detroit, MI 48201, USA</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="aff5">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff68">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="aff5">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="aff68">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="aff68">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, VIC 3053, Australia</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="aff69">Anatomical Pathology, The Alfred Hospital, Melbourne, VIC 3181, Australia</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="aff54">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="aff54">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><affiliation><nlm:aff id="aff54">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="aff70">Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="aff71">Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, QC G1V 4G2, Canada</nlm:aff></affiliation></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name><affiliation><nlm:aff id="aff72">Department of Medicine, McGill University, Montreal, QC H3A 1A1, Canada and Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC H3A 1A1, Canada</nlm:aff></affiliation></author><author><name sortKey="Labreche, France" sort="Labreche, France" uniqKey="Labreche F" first="France" last="Labrèche">France Labrèche</name><affiliation><nlm:aff id="aff73">Département de médecine sociale et préventive, Département de santé environnementale et santé au travail, Université de Montréal, Montreal, QC H3A 3C2, Canada</nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="aff71">Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, QC G1V 4G2, Canada</nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo-Hwang" last="Teo">Soo-Hwang Teo</name><affiliation><nlm:aff id="aff74">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, 47500 Selangor, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="aff75">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng-Har" last="Yip">Cheng-Har Yip</name><affiliation><nlm:aff id="aff75">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Phuah, Sze Yee" sort="Phuah, Sze Yee" uniqKey="Phuah S" first="Sze-Yee" last="Phuah">Sze-Yee Phuah</name><affiliation><nlm:aff id="aff74">Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, 47500 Selangor, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="aff75">Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="aff76">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="aff77">Faculty of Medicine (Faculty Division Ahus), University of Oslo (UiO), 0318 Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Grenaker Aln S, Grethe" sort="Grenaker Aln S, Grethe" uniqKey="Grenaker Aln S G" first="Grethe" last="Grenaker Aln S">Grethe Grenaker Aln S</name><affiliation><nlm:aff id="aff76">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name><affiliation><nlm:aff id="aff76">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="aff77">Faculty of Medicine (Faculty Division Ahus), University of Oslo (UiO), 0318 Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Deming Halverson, Sandra" sort="Deming Halverson, Sandra" uniqKey="Deming Halverson S" first="Sandra" last="Deming-Halverson">Sandra Deming-Halverson</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Martha" sort="Shrubsole, Martha" uniqKey="Shrubsole M" first="Martha" last="Shrubsole">Martha Shrubsole</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="aff79">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="aff79">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="aff80">Department of Oncology, Oulu University Hospital, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kauppila, Saila" sort="Kauppila, Saila" uniqKey="Kauppila S" first="Saila" last="Kauppila">Saila Kauppila</name><affiliation><nlm:aff id="aff80">Department of Oncology, Oulu University Hospital, University of Oulu, 90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="aff81">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="aff82">Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="aff81">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="aff83">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 1A8, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="aff81">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name><affiliation><nlm:aff id="aff81">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="aff84">Department of Human Genetics & Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="aff85">Department of Surgical Oncology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline M" sort="Seynaeve, Caroline M" uniqKey="Seynaeve C" first="Caroline M." last="Seynaeve">Caroline M. Seynaeve</name><affiliation><nlm:aff id="aff86">Department of Medical Oncology, Erasmus MC Cancer Institute, 3075 EA Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="aff14">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff87">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="aff88">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="aff88">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="aff89">Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw 02-781, Poland</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="aff90">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hartef" sort="Darabi, Hartef" uniqKey="Darabi H" first="Hartef" last="Darabi">Hartef Darabi</name><affiliation><nlm:aff id="aff90">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Kimael" sort="Eriksson, Kimael" uniqKey="Eriksson K" first="Kimael" last="Eriksson">Kimael Eriksson</name><affiliation><nlm:aff id="aff90">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="aff86">Department of Medical Oncology, Erasmus MC Cancer Institute, 3075 EA Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation><nlm:aff id="aff86">Department of Medical Oncology, Erasmus MC Cancer Institute, 3075 EA Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name><affiliation><nlm:aff id="aff91">Department of Clinical Genetics, Erasmus University Medical Center, 3008 AE Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H. M." last="Van Deurzen">Carolien H. M. Van Deurzen</name><affiliation><nlm:aff id="aff92">Department of Pathology, Erasmus University Medical Center, 3008 AE Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="aff90">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="aff93">Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="aff93">Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><affiliation><nlm:aff id="aff90">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Lu, Wei" sort="Lu, Wei" uniqKey="Lu W" first="Wei" last="Lu">Wei Lu</name><affiliation><nlm:aff id="aff94">Shanghai Center for Disease Control and Prevention, Shanghai 200336, China</nlm:aff></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation><nlm:aff id="aff95">Department of Epidemiology, Shanghai Cancer Institute, Shanghai 200032, China</nlm:aff></affiliation></author><author><name sortKey="Cai, Hui" sort="Cai, Hui" uniqKey="Cai H" first="Hui" last="Cai">Hui Cai</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="aff96">CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, S10 2RX, UK</nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="aff96">CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, S10 2RX, UK</nlm:aff></affiliation></author><author><name sortKey="Blot, William" sort="Blot, William" uniqKey="Blot W" first="William" last="Blot">William Blot</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation><affiliation><nlm:aff id="aff96">CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, S10 2RX, UK</nlm:aff></affiliation></author><author><name sortKey="Signorello, Lisa B" sort="Signorello, Lisa B" uniqKey="Signorello L" first="Lisa B." last="Signorello">Lisa B. Signorello</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation><affiliation><nlm:aff id="aff97">International Epidemiology Institute, Rockville, MD 20850, USA</nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="aff78">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Harrington, Patricia" sort="Harrington, Patricia" uniqKey="Harrington P" first="Patricia" last="Harrington">Patricia Harrington</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Tyrer, Jonathan" sort="Tyrer, Jonathan" uniqKey="Tyrer J" first="Jonathan" last="Tyrer">Jonathan Tyrer</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="aff98">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="aff99">Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 110-799, Korea</nlm:aff></affiliation></author><author><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name><affiliation><nlm:aff id="aff99">Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 110-799, Korea</nlm:aff></affiliation></author><author><name sortKey="Park, Sue K" sort="Park, Sue K" uniqKey="Park S" first="Sue K." last="Park">Sue K. Park</name><affiliation><nlm:aff id="aff98">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation></author><author><name sortKey="Noh, Dong Young" sort="Noh, Dong Young" uniqKey="Noh D" first="Dong-Young" last="Noh">Dong-Young Noh</name><affiliation><nlm:aff id="aff100">Department of Surgery, Seoul National University College of Medicine, Seoul 110-799, Korea</nlm:aff></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation><nlm:aff id="aff101">Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore and National University Health System, Singapore 119228, Singapore</nlm:aff></affiliation></author><author><name sortKey="Hui, Miao" sort="Hui, Miao" uniqKey="Hui M" first="Miao" last="Hui">Miao Hui</name><affiliation><nlm:aff id="aff101">Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore and National University Health System, Singapore 119228, Singapore</nlm:aff></affiliation></author><author><name sortKey="Lim, Wei Yen" sort="Lim, Wei Yen" uniqKey="Lim W" first="Wei-Yen" last="Lim">Wei-Yen Lim</name><affiliation><nlm:aff id="aff101">Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore and National University Health System, Singapore 119228, Singapore</nlm:aff></affiliation></author><author><name sortKey="Buhari, Shaik A" sort="Buhari, Shaik A" uniqKey="Buhari S" first="Shaik A." last="Buhari">Shaik A. Buhari</name><affiliation><nlm:aff id="aff102">Division of General Surgery, National University Health System, Singapore 119228</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="aff103">Molecular Genetics of Breast Cancer, German Cancer Research Centre (DKFZ), 69120 Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Forsti, Asta" sort="Forsti, Asta" uniqKey="Forsti A" first="Asta" last="Försti">Asta Försti</name><affiliation><nlm:aff id="aff104">Center for Primary Health Care Research, Clinical Research Centre (CRC), Skanes universitetssjukhus, 20502 Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Rudiger, Thomas" sort="Rudiger, Thomas" uniqKey="Rudiger T" first="Thomas" last="Rüdiger">Thomas Rüdiger</name><affiliation><nlm:aff id="aff105">Institute of Pathology, Städtisches Klinikum Karlsruhe, 76133 Karlsruhe, Germany</nlm:aff></affiliation></author><author><name sortKey="Ulmer, Hans Ulrich" sort="Ulmer, Hans Ulrich" uniqKey="Ulmer H" first="Hans-Ulrich" last="Ulmer">Hans-Ulrich Ulmer</name><affiliation><nlm:aff id="aff106">Frauenklinik der Stadtklinik Baden-Baden, 76532 Baden-Baden, Germany</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="aff107">Department of Genetics and Pathology, Pomeranian Medical University, u. Polabska 4, 70-115 Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="aff107">Department of Genetics and Pathology, Pomeranian Medical University, u. Polabska 4, 70-115 Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="aff107">Department of Genetics and Pathology, Pomeranian Medical University, u. Polabska 4, 70-115 Szczecin, Poland</nlm:aff></affiliation><affiliation><nlm:aff id="aff108">Postgraduate School of Molecular Medicine, Warsaw Medical University, ul. Żwirki i Wigury 61, 02-091 Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="aff107">Department of Genetics and Pathology, Pomeranian Medical University, u. Polabska 4, 70-115 Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="aff109">National Cancer Institute, Bangkok 10400, Thailand</nlm:aff></affiliation></author><author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name><affiliation><nlm:aff id="aff110">International Agency for Research on Cancer, 69372 Lyon Cedex 08, France</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="aff110">International Agency for Research on Cancer, 69372 Lyon Cedex 08, France</nlm:aff></affiliation></author><author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name><affiliation><nlm:aff id="aff110">International Agency for Research on Cancer, 69372 Lyon Cedex 08, France</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="aff66">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation><nlm:aff id="aff66">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation><nlm:aff id="aff111">Molecular Diagnostics Laboratory, INRASTES, NSCR Demokritos, Athens 15310, Greece</nlm:aff></affiliation></author><author><name sortKey="Pilarski, Robert" sort="Pilarski, Robert" uniqKey="Pilarski R" first="Robert" last="Pilarski">Robert Pilarski</name><affiliation><nlm:aff id="aff112">Department of Internal Medicine, James Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA</nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="aff113">Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="aff114">Colleague of Public Health, China Medical University, Taichung 40402, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hsiung, Chia Ni" sort="Hsiung, Chia Ni" uniqKey="Hsiung C" first="Chia-Ni" last="Hsiung">Chia-Ni Hsiung</name><affiliation><nlm:aff id="aff113">Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Wu, Pei Ei" sort="Wu, Pei Ei" uniqKey="Wu P" first="Pei-Ei" last="Wu">Pei-Ei Wu</name><affiliation><nlm:aff id="aff114">Colleague of Public Health, China Medical University, Taichung 40402, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hou, Ming Feng" sort="Hou, Ming Feng" uniqKey="Hou M" first="Ming-Feng" last="Hou">Ming-Feng Hou</name><affiliation><nlm:aff id="aff115">Taiwan Biobank and Cancer Center and Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="aff89">Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw 02-781, Poland</nlm:aff></affiliation><affiliation><nlm:aff id="aff116">Division of Breast Cancer Research, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="aff14">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff116">Division of Breast Cancer Research, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="aff14">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff116">Division of Breast Cancer Research, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK</nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J." last="Schoemaker">Minouk J. Schoemaker</name><affiliation><nlm:aff id="aff89">Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw 02-781, Poland</nlm:aff></affiliation></author><author><name sortKey="Ponder, Bruce A J" sort="Ponder, Bruce A J" uniqKey="Ponder B" first="Bruce A. J." last="Ponder">Bruce A. J. Ponder</name><affiliation><nlm:aff id="aff1">CRUK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="aff2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author></analytic><series><title level="j">American Journal of Human Genetics</title><idno type="ISSN">0002-9297</idno><idno type="eISSN">1537-6605</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The 10q26 locus in the second intron of <italic>FGFR2</italic> is the locus most strongly associated with estrogen-receptor-positive breast cancer in genome-wide association studies. We conducted fine-scale mapping in case-control studies genotyped with a custom chip (iCOGS), comprising 41 studies (n = 89,050) of European ancestry, 9 Asian ancestry studies (n = 13,983), and 2 African ancestry studies (n = 2,028) from the Breast Cancer Association Consortium. We identified three statistically independent risk signals within the locus. Within risk signals 1 and 3, genetic analysis identified five and two variants, respectively, highly correlated with the most strongly associated SNPs. By using a combination of genetic fine mapping, data on DNase hypersensitivity, and electrophoretic mobility shift assays to study protein-DNA binding, we identified rs35054928, rs2981578, and rs45631563 as putative functional SNPs. Chromatin immunoprecipitation showed that FOXA1 preferentially bound to the risk-associated allele (C) of rs2981578 and was able to recruit ERα to this site in an allele-specific manner, whereas E2F1 preferentially bound the risk variant of rs35054928. The risk alleles were preferentially found in open chromatin and bound by Ser5 phosphorylated RNA polymerase II, suggesting that the risk alleles are associated with changes in transcription. Chromatin conformation capture demonstrated that the risk region was able to interact with the promoter of <italic>FGFR2</italic>, the likely target gene of this risk region. A role for FOXA1 in mediating breast cancer susceptibility at this locus is consistent with the finding that the <italic>FGFR2</italic> risk locus primarily predisposes to estrogen-receptor-positive disease.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Hum Genet</journal-id><journal-id journal-id-type="iso-abbrev">Am. J. Hum. Genet</journal-id><journal-title-group><journal-title>American Journal of Human Genetics</journal-title></journal-title-group><issn pub-type="ppub">0002-9297</issn><issn pub-type="epub">1537-6605</issn><publisher><publisher-name>Elsevier</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24290378</article-id><article-id pub-id-type="pmc">3852923</article-id><article-id pub-id-type="publisher-id">S0002-9297(13)00483-7</article-id><article-id pub-id-type="doi">10.1016/j.ajhg.2013.10.026</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus: Putative Functional Variants Differentially Bind FOXA1 and E2F1</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Meyer</surname><given-names>Kerstin 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contrib-type="author"><name><surname>García-Closas</surname><given-names>Montserrat</given-names></name><xref rid="aff14" ref-type="aff">14</xref><xref rid="aff87" ref-type="aff">87</xref></contrib><contrib contrib-type="author"><name><surname>Figueroa</surname><given-names>Jonine</given-names></name><xref rid="aff88" ref-type="aff">88</xref></contrib><contrib contrib-type="author"><name><surname>Chanock</surname><given-names>Stephen J.</given-names></name><xref rid="aff88" ref-type="aff">88</xref></contrib><contrib contrib-type="author"><name><surname>Lissowska</surname><given-names>Jolanta</given-names></name><xref rid="aff89" ref-type="aff">89</xref></contrib><contrib contrib-type="author"><name><surname>Czene</surname><given-names>Kamila</given-names></name><xref rid="aff90" ref-type="aff">90</xref></contrib><contrib contrib-type="author"><name><surname>Darabi</surname><given-names>Hartef</given-names></name><xref rid="aff90" ref-type="aff">90</xref></contrib><contrib contrib-type="author"><name><surname>Eriksson</surname><given-names>Kimael</given-names></name><xref rid="aff90" ref-type="aff">90</xref></contrib><contrib contrib-type="author"><name><surname>Hooning</surname><given-names>Maartje J.</given-names></name><xref rid="aff86" ref-type="aff">86</xref></contrib><contrib contrib-type="author"><name><surname>Martens</surname><given-names>John W.M.</given-names></name><xref rid="aff86" ref-type="aff">86</xref></contrib><contrib contrib-type="author"><name><surname>van den Ouweland</surname><given-names>Ans M.W.</given-names></name><xref rid="aff91" ref-type="aff">91</xref></contrib><contrib contrib-type="author"><name><surname>van Deurzen</surname><given-names>Carolien H.M.</given-names></name><xref rid="aff92" ref-type="aff">92</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><xref rid="aff90" ref-type="aff">90</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Jingmei</given-names></name><xref rid="aff93" ref-type="aff">93</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Jianjun</given-names></name><xref rid="aff93" ref-type="aff">93</xref></contrib><contrib contrib-type="author"><name><surname>Humphreys</surname><given-names>Keith</given-names></name><xref rid="aff90" ref-type="aff">90</xref></contrib><contrib contrib-type="author"><name><surname>Shu</surname><given-names>Xiao-Ou</given-names></name><xref rid="aff78" ref-type="aff">78</xref></contrib><contrib contrib-type="author"><name><surname>Lu</surname><given-names>Wei</given-names></name><xref rid="aff94" ref-type="aff">94</xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Yu-Tang</given-names></name><xref rid="aff95" ref-type="aff">95</xref></contrib><contrib contrib-type="author"><name><surname>Cai</surname><given-names>Hui</given-names></name><xref rid="aff78" ref-type="aff">78</xref></contrib><contrib contrib-type="author"><name><surname>Cox</surname><given-names>Angela</given-names></name><xref rid="aff96" ref-type="aff">96</xref></contrib><contrib contrib-type="author"><name><surname>Reed</surname><given-names>Malcolm W.R.</given-names></name><xref rid="aff96" ref-type="aff">96</xref></contrib><contrib contrib-type="author"><name><surname>Blot</surname><given-names>William</given-names></name><xref rid="aff78" ref-type="aff">78</xref><xref rid="aff96" ref-type="aff">96</xref></contrib><contrib contrib-type="author"><name><surname>Signorello</surname><given-names>Lisa B.</given-names></name><xref rid="aff78" ref-type="aff">78</xref><xref rid="aff97" ref-type="aff">97</xref></contrib><contrib contrib-type="author"><name><surname>Cai</surname><given-names>Qiuyin</given-names></name><xref rid="aff78" ref-type="aff">78</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul D.P.</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Ghoussaini</surname><given-names>Maya</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Harrington</surname><given-names>Patricia</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Tyrer</surname><given-names>Jonathan</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Kang</surname><given-names>Daehee</given-names></name><xref rid="aff98" ref-type="aff">98</xref><xref rid="aff99" ref-type="aff">99</xref></contrib><contrib contrib-type="author"><name><surname>Choi</surname><given-names>Ji-Yeob</given-names></name><xref rid="aff99" ref-type="aff">99</xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Sue K.</given-names></name><xref rid="aff98" ref-type="aff">98</xref></contrib><contrib contrib-type="author"><name><surname>Noh</surname><given-names>Dong-Young</given-names></name><xref rid="aff100" ref-type="aff">100</xref></contrib><contrib contrib-type="author"><name><surname>Hartman</surname><given-names>Mikael</given-names></name><xref rid="aff101" ref-type="aff">101</xref></contrib><contrib contrib-type="author"><name><surname>Hui</surname><given-names>Miao</given-names></name><xref rid="aff101" ref-type="aff">101</xref></contrib><contrib contrib-type="author"><name><surname>Lim</surname><given-names>Wei-Yen</given-names></name><xref rid="aff101" ref-type="aff">101</xref></contrib><contrib contrib-type="author"><name><surname>Buhari</surname><given-names>Shaik A.</given-names></name><xref rid="aff102" ref-type="aff">102</xref></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name><xref rid="aff103" ref-type="aff">103</xref></contrib><contrib contrib-type="author"><name><surname>Försti</surname><given-names>Asta</given-names></name><xref rid="aff104" ref-type="aff">104</xref></contrib><contrib contrib-type="author"><name><surname>Rüdiger</surname><given-names>Thomas</given-names></name><xref rid="aff105" ref-type="aff">105</xref></contrib><contrib contrib-type="author"><name><surname>Ulmer</surname><given-names>Hans-Ulrich</given-names></name><xref rid="aff106" ref-type="aff">106</xref></contrib><contrib contrib-type="author"><name><surname>Jakubowska</surname><given-names>Anna</given-names></name><xref rid="aff107" ref-type="aff">107</xref></contrib><contrib contrib-type="author"><name><surname>Lubinski</surname><given-names>Jan</given-names></name><xref rid="aff107" ref-type="aff">107</xref></contrib><contrib contrib-type="author"><name><surname>Jaworska</surname><given-names>Katarzyna</given-names></name><xref rid="aff107" ref-type="aff">107</xref><xref rid="aff108" ref-type="aff">108</xref></contrib><contrib contrib-type="author"><name><surname>Durda</surname><given-names>Katarzyna</given-names></name><xref rid="aff107" ref-type="aff">107</xref></contrib><contrib contrib-type="author"><name><surname>Sangrajrang</surname><given-names>Suleeporn</given-names></name><xref rid="aff109" ref-type="aff">109</xref></contrib><contrib contrib-type="author"><name><surname>Gaborieau</surname><given-names>Valerie</given-names></name><xref rid="aff110" ref-type="aff">110</xref></contrib><contrib contrib-type="author"><name><surname>Brennan</surname><given-names>Paul</given-names></name><xref rid="aff110" ref-type="aff">110</xref></contrib><contrib contrib-type="author"><name><surname>McKay</surname><given-names>James</given-names></name><xref rid="aff110" ref-type="aff">110</xref></contrib><contrib contrib-type="author"><name><surname>Vachon</surname><given-names>Celine</given-names></name><xref rid="aff66" ref-type="aff">66</xref></contrib><contrib contrib-type="author"><name><surname>Slager</surname><given-names>Susan</given-names></name><xref rid="aff66" ref-type="aff">66</xref></contrib><contrib contrib-type="author"><name><surname>Fostira</surname><given-names>Florentia</given-names></name><xref rid="aff111" ref-type="aff">111</xref></contrib><contrib contrib-type="author"><name><surname>Pilarski</surname><given-names>Robert</given-names></name><xref rid="aff112" ref-type="aff">112</xref></contrib><contrib contrib-type="author"><name><surname>Shen</surname><given-names>Chen-Yang</given-names></name><xref rid="aff113" ref-type="aff">113</xref><xref rid="aff114" ref-type="aff">114</xref></contrib><contrib contrib-type="author"><name><surname>Hsiung</surname><given-names>Chia-Ni</given-names></name><xref rid="aff113" ref-type="aff">113</xref></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Pei-Ei</given-names></name><xref rid="aff114" ref-type="aff">114</xref></contrib><contrib contrib-type="author"><name><surname>Hou</surname><given-names>Ming-Feng</given-names></name><xref rid="aff115" ref-type="aff">115</xref></contrib><contrib contrib-type="author"><name><surname>Swerdlow</surname><given-names>Anthony</given-names></name><xref rid="aff89" ref-type="aff">89</xref><xref rid="aff116" ref-type="aff">116</xref></contrib><contrib contrib-type="author"><name><surname>Ashworth</surname><given-names>Alan</given-names></name><xref rid="aff14" ref-type="aff">14</xref><xref rid="aff116" ref-type="aff">116</xref></contrib><contrib contrib-type="author"><name><surname>Orr</surname><given-names>Nick</given-names></name><xref rid="aff14" ref-type="aff">14</xref><xref rid="aff116" ref-type="aff">116</xref></contrib><contrib contrib-type="author"><name><surname>Schoemaker</surname><given-names>Minouk J.</given-names></name><xref rid="aff89" ref-type="aff">89</xref></contrib><contrib contrib-type="author"><name><surname>Ponder</surname><given-names>Bruce A.J.</given-names></name><xref rid="aff1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M.</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib></contrib-group><aff id="aff1"><label>1</label>CRUK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK</aff><aff id="aff2"><label>2</label>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK</aff><aff id="aff3"><label>3</label>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia</aff><aff id="aff4"><label>4</label>School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia</aff><aff id="aff5"><label>5</label>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, VIC 3010, Australia</aff><aff id="aff6"><label>6</label>Department of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia</aff><aff id="aff7"><label>7</label>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands</aff><aff id="aff8"><label>8</label>Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK and Institute of Population Health, University of Manchester, Manchester M13 9PL, UK</aff><aff id="aff9"><label>9</label>Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK</aff><aff id="aff10"><label>10</label>Ministry of Public Health, Bangkok 10400, Thailand</aff><aff id="aff11"><label>11</label>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany</aff><aff id="aff12"><label>12</label>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA 90095, USA</aff><aff id="aff13"><label>13</label>London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</aff><aff id="aff14"><label>14</label>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK</aff><aff id="aff15"><label>15</label>Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, London SE1 9RT, UK</aff><aff id="aff16"><label>16</label>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK</aff><aff id="aff17"><label>17</label>Clinical Science Institute, University Hospital Galway, Galway, Ireland</aff><aff id="aff18"><label>18</label>Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany</aff><aff id="aff19"><label>19</label>National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany</aff><aff id="aff20"><label>20</label>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</aff><aff id="aff21"><label>21</label>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population) and University Paris-Sud, UMRS 1018, 94807 Villejuif, France</aff><aff id="aff22"><label>22</label>Université Paris Sorbonne Cité, UMR-S775 Inserm, 75270 Paris Cedex 06, France</aff><aff id="aff23"><label>23</label>Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, 2730 Herlev, Denmark</aff><aff id="aff24"><label>24</label>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, 2730 Herlev, Denmark</aff><aff id="aff25"><label>25</label>Genetic & Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain</aff><aff id="aff26"><label>26</label>Servicio de Oncología Médica, Hospital Universitario La Paz, 28046 Madrid, Spain</aff><aff id="aff27"><label>27</label>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, 33012 Oviedo, Spain</aff><aff id="aff28"><label>28</label>Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain and Centro de Investigación en Red de Enfermedades Raras (CIBERER), 46010 Valencia, Spain</aff><aff id="aff29"><label>29</label>Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</aff><aff id="aff30"><label>30</label>Department of Epidemiology, University of California, Irvine, Irvine, CA 92697, USA</aff><aff id="aff31"><label>31</label>Cancer Prevention Institute of California, Fremont, CA 94538, USA</aff><aff id="aff32"><label>32</label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</aff><aff id="aff33"><label>33</label>Saarland Cancer Registry, 66024 Saarbrücken, Germany</aff><aff id="aff34"><label>34</label>Division of Gynaecology and Obstetrics, Technische Universität München, 81675 Munich, Germany</aff><aff id="aff35"><label>35</label>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics at the University Cologne, 50931 Cologne, Germany</aff><aff id="aff36"><label>36</label>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107 Leipzig, Germany</aff><aff id="aff37"><label>37</label>Department of Gynaecology and Obstetrics, Ludwig-Maximilians-Universität, 80539 Munich, Germany</aff><aff id="aff38"><label>38</label>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany and University of Tübingen, 72074 Tübingen, Germany</aff><aff id="aff39"><label>39</label>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), 44789 Bochum, Germany</aff><aff id="aff40"><label>40</label>Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, 53113 Bonn, Germany</aff><aff id="aff41"><label>41</label>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland</aff><aff id="aff42"><label>42</label>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland</aff><aff id="aff43"><label>43</label>Department of Oncology, Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland</aff><aff id="aff44"><label>44</label>Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka 812-8582, Japan</aff><aff id="aff45"><label>45</label>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan</aff><aff id="aff46"><label>46</label>Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan</aff><aff id="aff47"><label>47</label>Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan</aff><aff id="aff48"><label>48</label>Department of Obstetrics and Gynaecology, Hannover Medical School, 30625 Hannover, Germany</aff><aff id="aff49"><label>49</label>Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany</aff><aff id="aff50"><label>50</label>Department of Molecular Medicine and Surgery, Karolinska Institutet, 17177 Stockholm, Sweden</aff><aff id="aff51"><label>51</label>Department of Oncology-Pathology, Karolinska Institutet, 17177 Stockholm, Sweden</aff><aff id="aff52"><label>52</label>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland and University of Eastern Finland, and Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70211 Kuopio, Finland</aff><aff id="aff53"><label>53</label>School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland and Cancer Center, Kuopio University Hospital, 70211 Kuopio, Finland</aff><aff id="aff54"><label>54</label>Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA</aff><aff id="aff55"><label>55</label>Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium</aff><aff id="aff56"><label>56</label>Department of Oncology, University of Leuven, 3000 Leuven, Belgium</aff><aff id="aff57"><label>57</label>Oncology Department, University Hospital Gasthuisberg, 3000 Leuven, Belgium</aff><aff id="aff58"><label>58</label>Universital Hospital Gasthuisberg, 3000 Leuven, Belgium</aff><aff id="aff59"><label>59</label>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany</aff><aff id="aff60"><label>60</label>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, 20246 Hamburg, Germany</aff><aff id="aff61"><label>61</label>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy</aff><aff id="aff62"><label>62</label>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, 20139 Milan, Italy</aff><aff id="aff63"><label>63</label>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), 20141 Milan, Italy</aff><aff id="aff64"><label>64</label>Department of Experimental Oncology, Istituto Europeo di Oncologia (IEO), 20141 Milan, Italy and Cogentech Cancer Genetic Test Laboratory, 20139 Milan, Italy</aff><aff id="aff65"><label>65</label>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</aff><aff id="aff66"><label>66</label>Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</aff><aff id="aff67"><label>67</label>Karmanos Cancer Center, Detroit, MI 48201, USA</aff><aff id="aff68"><label>68</label>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, VIC 3053, Australia</aff><aff id="aff69"><label>69</label>Anatomical Pathology, The Alfred Hospital, Melbourne, VIC 3181, Australia</aff><aff id="aff70"><label>70</label>Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA</aff><aff id="aff71"><label>71</label>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, QC G1V 4G2, Canada</aff><aff id="aff72"><label>72</label>Department of Medicine, McGill University, Montreal, QC H3A 1A1, Canada and Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC H3A 1A1, Canada</aff><aff id="aff73"><label>73</label>Département de médecine sociale et préventive, Département de santé environnementale et santé au travail, Université de Montréal, Montreal, QC H3A 3C2, Canada</aff><aff id="aff74"><label>74</label>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, 47500 Selangor, Malaysia</aff><aff id="aff75"><label>75</label>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 50603 Kuala Lumpur, Malaysia</aff><aff id="aff76"><label>76</label>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway</aff><aff id="aff77"><label>77</label>Faculty of Medicine (Faculty Division Ahus), University of Oslo (UiO), 0318 Oslo, Norway</aff><aff id="aff78"><label>78</label>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA</aff><aff id="aff79"><label>79</label>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital, 90014 Oulu, Finland</aff><aff id="aff80"><label>80</label>Department of Oncology, Oulu University Hospital, University of Oulu, 90014 Oulu, Finland</aff><aff id="aff81"><label>81</label>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada</aff><aff id="aff82"><label>82</label>Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada</aff><aff id="aff83"><label>83</label>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 1A8, Canada</aff><aff id="aff84"><label>84</label>Department of Human Genetics & Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands</aff><aff id="aff85"><label>85</label>Department of Surgical Oncology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands</aff><aff id="aff86"><label>86</label>Department of Medical Oncology, Erasmus MC Cancer Institute, 3075 EA Rotterdam, the Netherlands</aff><aff id="aff87"><label>87</label>Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK</aff><aff id="aff88"><label>88</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA</aff><aff id="aff89"><label>89</label>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw 02-781, Poland</aff><aff id="aff90"><label>90</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden</aff><aff id="aff91"><label>91</label>Department of Clinical Genetics, Erasmus University Medical Center, 3008 AE Rotterdam, the Netherlands</aff><aff id="aff92"><label>92</label>Department of Pathology, Erasmus University Medical Center, 3008 AE Rotterdam, the Netherlands</aff><aff id="aff93"><label>93</label>Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore</aff><aff id="aff94"><label>94</label>Shanghai Center for Disease Control and Prevention, Shanghai 200336, China</aff><aff id="aff95"><label>95</label>Department of Epidemiology, Shanghai Cancer Institute, Shanghai 200032, China</aff><aff id="aff96"><label>96</label>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, S10 2RX, UK</aff><aff id="aff97"><label>97</label>International Epidemiology Institute, Rockville, MD 20850, USA</aff><aff id="aff98"><label>98</label>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea</aff><aff id="aff99"><label>99</label>Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 110-799, Korea</aff><aff id="aff100"><label>100</label>Department of Surgery, Seoul National University College of Medicine, Seoul 110-799, Korea</aff><aff id="aff101"><label>101</label>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore and National University Health System, Singapore 119228, Singapore</aff><aff id="aff102"><label>102</label>Division of General Surgery, National University Health System, Singapore 119228</aff><aff id="aff103"><label>103</label>Molecular Genetics of Breast Cancer, German Cancer Research Centre (DKFZ), 69120 Heidelberg, Germany</aff><aff id="aff104"><label>104</label>Center for Primary Health Care Research, Clinical Research Centre (CRC), Skanes universitetssjukhus, 20502 Malmö, Sweden</aff><aff id="aff105"><label>105</label>Institute of Pathology, Städtisches Klinikum Karlsruhe, 76133 Karlsruhe, Germany</aff><aff id="aff106"><label>106</label>Frauenklinik der Stadtklinik Baden-Baden, 76532 Baden-Baden, Germany</aff><aff id="aff107"><label>107</label>Department of Genetics and Pathology, Pomeranian Medical University, u. Polabska 4, 70-115 Szczecin, Poland</aff><aff id="aff108"><label>108</label>Postgraduate School of Molecular Medicine, Warsaw Medical University, ul. Żwirki i Wigury 61, 02-091 Warsaw, Poland</aff><aff id="aff109"><label>109</label>National Cancer Institute, Bangkok 10400, Thailand</aff><aff id="aff110"><label>110</label>International Agency for Research on Cancer, 69372 Lyon Cedex 08, France</aff><aff id="aff111"><label>111</label>Molecular Diagnostics Laboratory, INRASTES, NSCR Demokritos, Athens 15310, Greece</aff><aff id="aff112"><label>112</label>Department of Internal Medicine, James Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA</aff><aff id="aff113"><label>113</label>Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan</aff><aff id="aff114"><label>114</label>Colleague of Public Health, China Medical University, Taichung 40402, Taiwan</aff><aff id="aff115"><label>115</label>Taiwan Biobank and Cancer Center and Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</aff><aff id="aff116"><label>116</label>Division of Breast Cancer Research, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK</aff><author-notes><corresp id="cor1"><label>∗</label>Corresponding author <email>kerstin.meyer@cruk.cam.ac.uk</email></corresp></author-notes><pub-date pub-type="ppub"><day>05</day><month>12</month><year>2013</year></pub-date><volume>93</volume><issue>6</issue><fpage>1046</fpage><lpage>1060</lpage><history><date date-type="received"><day>1</day><month>8</month><year>2013</year></date><date date-type="rev-recd"><day>15</day><month>10</month><year>2013</year></date><date date-type="accepted"><day>28</day><month>10</month><year>2013</year></date></history><permissions><copyright-statement>© 2013 The American Society of Human Genetics. Published by Elsevier Ltd. All right reserved.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>The American Society of Human Genetics</copyright-holder></permissions><abstract><p>The 10q26 locus in the second intron of <italic>FGFR2</italic> is the locus most strongly associated with estrogen-receptor-positive breast cancer in genome-wide association studies. We conducted fine-scale mapping in case-control studies genotyped with a custom chip (iCOGS), comprising 41 studies (n = 89,050) of European ancestry, 9 Asian ancestry studies (n = 13,983), and 2 African ancestry studies (n = 2,028) from the Breast Cancer Association Consortium. We identified three statistically independent risk signals within the locus. Within risk signals 1 and 3, genetic analysis identified five and two variants, respectively, highly correlated with the most strongly associated SNPs. By using a combination of genetic fine mapping, data on DNase hypersensitivity, and electrophoretic mobility shift assays to study protein-DNA binding, we identified rs35054928, rs2981578, and rs45631563 as putative functional SNPs. Chromatin immunoprecipitation showed that FOXA1 preferentially bound to the risk-associated allele (C) of rs2981578 and was able to recruit ERα to this site in an allele-specific manner, whereas E2F1 preferentially bound the risk variant of rs35054928. The risk alleles were preferentially found in open chromatin and bound by Ser5 phosphorylated RNA polymerase II, suggesting that the risk alleles are associated with changes in transcription. Chromatin conformation capture demonstrated that the risk region was able to interact with the promoter of <italic>FGFR2</italic>, the likely target gene of this risk region. A role for FOXA1 in mediating breast cancer susceptibility at this locus is consistent with the finding that the <italic>FGFR2</italic> risk locus primarily predisposes to estrogen-receptor-positive disease.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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