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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Finding a cure for HIV: will it ever be achievable?</title><author><name sortKey="Lewin, Sharon R" sort="Lewin, Sharon R" uniqKey="Lewin S" first="Sharon R" last="Lewin">Sharon R. Lewin</name><affiliation><nlm:aff id="I1">Department of Medicine, Monash University, (99 Commercial Rd), Melbourne, (3004), Australia</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Infectious Diseases Unit, Alfred Hospital, (85 Commercial Rd), Melbourne, (3004), Australia</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Centre of Virology, Burnet Institute, (85 Commercial Rd), Melbourne, (3004), Australia</nlm:aff></affiliation></author><author><name sortKey="Evans, Vanessa A" sort="Evans, Vanessa A" uniqKey="Evans V" first="Vanessa A" last="Evans">Vanessa A. Evans</name><affiliation><nlm:aff id="I1">Department of Medicine, Monash University, (99 Commercial Rd), Melbourne, (3004), Australia</nlm:aff></affiliation></author><author><name sortKey="Elliott, Julian H" sort="Elliott, Julian H" uniqKey="Elliott J" first="Julian H" last="Elliott">Julian H. Elliott</name><affiliation><nlm:aff id="I1">Department of Medicine, Monash University, (99 Commercial Rd), Melbourne, (3004), Australia</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Infectious Diseases Unit, Alfred Hospital, (85 Commercial Rd), Melbourne, (3004), Australia</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Centre of Virology, Burnet Institute, (85 Commercial Rd), Melbourne, (3004), Australia</nlm:aff></affiliation></author><author><name sortKey="Spire, Bruno" sort="Spire, Bruno" uniqKey="Spire B" first="Bruno" last="Spire">Bruno Spire</name><affiliation><nlm:aff id="I4">SE4S, INSERM UMR 912, (23 rue Stanislas Torrents), Marseille, (13006), France</nlm:aff></affiliation><affiliation><nlm:aff id="I5">SE4S, Université de la Méditerranée, IRD, (23 rue Stanislas Torrents), Marseille, (13006), France</nlm:aff></affiliation><affiliation><nlm:aff id="I6">AIDES, (14 rue Scandicci, Pantin (93508), France</nlm:aff></affiliation></author><author><name sortKey="Chomont, Nicolas" sort="Chomont, Nicolas" uniqKey="Chomont N" first="Nicolas" last="Chomont">Nicolas Chomont</name><affiliation><nlm:aff id="I7">Vaccine and Gene Therapy Institute, (11350 SW Village Parkway), Port St Lucie, (34987), FL, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21255462</idno><idno type="pmc">3037295</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037295</idno><idno type="RBID">PMC:3037295</idno><idno type="doi">10.1186/1758-2652-14-4</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001648</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001648</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Finding a cure for HIV: will it ever be achievable?</title><author><name sortKey="Lewin, Sharon R" sort="Lewin, Sharon R" uniqKey="Lewin S" first="Sharon R" last="Lewin">Sharon R. Lewin</name><affiliation><nlm:aff id="I1">Department of Medicine, Monash University, (99 Commercial Rd), Melbourne, (3004), Australia</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Infectious Diseases Unit, Alfred Hospital, (85 Commercial Rd), Melbourne, (3004), Australia</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Centre of Virology, Burnet Institute, (85 Commercial Rd), Melbourne, (3004), Australia</nlm:aff></affiliation></author><author><name sortKey="Evans, Vanessa A" sort="Evans, Vanessa A" uniqKey="Evans V" first="Vanessa A" last="Evans">Vanessa A. Evans</name><affiliation><nlm:aff id="I1">Department of Medicine, Monash University, (99 Commercial Rd), Melbourne, (3004), Australia</nlm:aff></affiliation></author><author><name sortKey="Elliott, Julian H" sort="Elliott, Julian H" uniqKey="Elliott J" first="Julian H" last="Elliott">Julian H. Elliott</name><affiliation><nlm:aff id="I1">Department of Medicine, Monash University, (99 Commercial Rd), Melbourne, (3004), Australia</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Infectious Diseases Unit, Alfred Hospital, (85 Commercial Rd), Melbourne, (3004), Australia</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Centre of Virology, Burnet Institute, (85 Commercial Rd), Melbourne, (3004), Australia</nlm:aff></affiliation></author><author><name sortKey="Spire, Bruno" sort="Spire, Bruno" uniqKey="Spire B" first="Bruno" last="Spire">Bruno Spire</name><affiliation><nlm:aff id="I4">SE4S, INSERM UMR 912, (23 rue Stanislas Torrents), Marseille, (13006), France</nlm:aff></affiliation><affiliation><nlm:aff id="I5">SE4S, Université de la Méditerranée, IRD, (23 rue Stanislas Torrents), Marseille, (13006), France</nlm:aff></affiliation><affiliation><nlm:aff id="I6">AIDES, (14 rue Scandicci, Pantin (93508), France</nlm:aff></affiliation></author><author><name sortKey="Chomont, Nicolas" sort="Chomont, Nicolas" uniqKey="Chomont N" first="Nicolas" last="Chomont">Nicolas Chomont</name><affiliation><nlm:aff id="I7">Vaccine and Gene Therapy Institute, (11350 SW Village Parkway), Port St Lucie, (34987), FL, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of the International AIDS Society</title><idno type="eISSN">1758-2652</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Combination antiretroviral therapy (cART) has led to a major reduction in HIV-related mortality and morbidity. However, HIV still cannot be cured. With the absence of an effective prophylactic or therapeutic vaccine, increasing numbers of infected people, emerging new toxicities secondary to cART and the need for life-long treatment, there is now a real urgency to find a cure for HIV.</p><p>There are currently multiple barriers to curing HIV. The most significant barrier is the establishment of a latent or "silent" infection in resting CD4+ T cells. In latent HIV infection, the virus is able to integrate into the host cell genome, but does not proceed to active replication. As a consequence, antiviral agents, as well as the immune system, are unable to eliminate these long-lived, latently infected cells. Reactivation of latently infected resting CD4+ T cells can then re-establish infection once cART is stopped. Other significant barriers to cure include residual viral replication in patients receiving cART, even when the virus is not detectable by conventional assays. In addition, HIV can be sequestered in anatomical reservoirs, such as the brain, gastrointestinal tract and genitourinary tract.</p><p>Achieving either a functional cure (long-term control of HIV in the absence of cART) or a sterilizing cure (elimination of all HIV-infected cells) remains a major challenge. Several studies have now demonstrated that treatment intensification appears to have little impact on latent reservoirs. Some potential and promising approaches that may reduce the latent reservoir include very early initiation of cART and the use of agents that could potentially reverse latent infection.</p><p>Agents that reverse latent infection will promote viral production; however, simultaneous administration of cART will prevent subsequent rounds of viral replication. Such drugs as histone deacetylase inhibitors, currently used and licensed for the treatment of some cancers, or activating latently infected resting cells with cytokines, such as IL-7 or prostratin, show promising results in reversing latency <italic>in vitro </italic>when used either alone or in combination. In order to move forward toward clinical trials that target eradication, there needs to be careful consideration of the risks and benefits of these approaches, agreement on the most informative endpoints for eradication studies and greater engagement of the infected community.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mocroft, A" uniqKey="Mocroft A">A Mocroft</name></author><author><name sortKey="Ledergerber, B" uniqKey="Ledergerber B">B Ledergerber</name></author><author><name sortKey="Katlama, C" uniqKey="Katlama C">C Katlama</name></author><author><name sortKey="Kirk, O" uniqKey="Kirk O">O Kirk</name></author><author><name sortKey="Reiss, P" uniqKey="Reiss P">P Reiss</name></author><author><name sortKey="D Arminio Monforte, A" uniqKey="D Arminio Monforte A">A d'Arminio Monforte</name></author><author><name sortKey="Knysz, B" uniqKey="Knysz B">B Knysz</name></author><author><name sortKey="Dietrich, M" uniqKey="Dietrich M">M Dietrich</name></author><author><name sortKey="Phillips, An" uniqKey="Phillips A">AN Phillips</name></author><author><name sortKey="Lundgren, Jd" uniqKey="Lundgren J">JD Lundgren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palella, Fj" uniqKey="Palella F">FJ Palella</name></author><author><name sortKey="Delaney, Km" uniqKey="Delaney K">KM Delaney</name></author><author><name sortKey="Moorman, Ac" uniqKey="Moorman A">AC Moorman</name></author><author><name sortKey="Loveless, Mo" uniqKey="Loveless M">MO Loveless</name></author><author><name sortKey="Fuhrer, J" uniqKey="Fuhrer J">J Fuhrer</name></author><author><name sortKey="Satten, Ga" uniqKey="Satten G">GA Satten</name></author><author><name sortKey="Aschman, Dj" uniqKey="Aschman D">DJ Aschman</name></author><author><name sortKey="Holmberg, Sd" uniqKey="Holmberg S">SD Holmberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braitstein, P" uniqKey="Braitstein P">P Braitstein</name></author><author><name sortKey="Brinkhof, Mw" uniqKey="Brinkhof M">MW Brinkhof</name></author><author><name sortKey="Dabis, F" uniqKey="Dabis F">F Dabis</name></author><author><name sortKey="Schechter, M" uniqKey="Schechter M">M Schechter</name></author><author><name sortKey="Boulle, A" uniqKey="Boulle A">A Boulle</name></author><author><name sortKey="Miotti, P" uniqKey="Miotti P">P Miotti</name></author><author><name sortKey="Wood, R" uniqKey="Wood R">R Wood</name></author><author><name sortKey="Laurent, C" uniqKey="Laurent C">C Laurent</name></author><author><name sortKey="Sprinz, E" uniqKey="Sprinz E">E Sprinz</name></author><author><name sortKey="Seyler, C" uniqKey="Seyler C">C Seyler</name></author><author><name sortKey="Bangsberg, Dr" uniqKey="Bangsberg D">DR Bangsberg</name></author><author><name sortKey="Balestre, E" uniqKey="Balestre E">E Balestre</name></author><author><name sortKey="Sterne, Ja" uniqKey="Sterne J">JA Sterne</name></author><author><name sortKey="May, M" uniqKey="May M">M May</name></author><author><name sortKey="Egger, M" uniqKey="Egger M">M Egger</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lohse, N" uniqKey="Lohse N">N Lohse</name></author><author><name sortKey="Hansen, Ab" uniqKey="Hansen A">AB Hansen</name></author><author><name sortKey="Pedersen, G" uniqKey="Pedersen G">G Pedersen</name></author><author><name sortKey="Kronborg, G" uniqKey="Kronborg G">G Kronborg</name></author><author><name sortKey="Gerstoft, J" uniqKey="Gerstoft J">J Gerstoft</name></author><author><name sortKey="Sorensen, Ht" uniqKey="Sorensen H">HT Sorensen</name></author><author><name sortKey="Vaeth, M" uniqKey="Vaeth M">M Vaeth</name></author><author><name sortKey="Obel, N" uniqKey="Obel N">N Obel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neuhaus, J" uniqKey="Neuhaus J">J Neuhaus</name></author><author><name sortKey="Angus, B" uniqKey="Angus B">B Angus</name></author><author><name sortKey="Kowalska, Jd" uniqKey="Kowalska J">JD Kowalska</name></author><author><name sortKey="La Rosa, A" uniqKey="La Rosa A">A La Rosa</name></author><author><name sortKey="Sampson, J" uniqKey="Sampson J">J Sampson</name></author><author><name sortKey="Wentworth, D" uniqKey="Wentworth D">D Wentworth</name></author><author><name sortKey="Mocroft, A" uniqKey="Mocroft A">A Mocroft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Friis Moller, N" uniqKey="Friis Moller N">N Friis-Moller</name></author><author><name sortKey="Sabin, Ca" uniqKey="Sabin C">CA Sabin</name></author><author><name sortKey="Weber, R" uniqKey="Weber R">R Weber</name></author><author><name sortKey="D Arminio Monforte, A" uniqKey="D Arminio Monforte A">A d'Arminio Monforte</name></author><author><name sortKey="El Sadr, Wm" uniqKey="El Sadr W">WM El-Sadr</name></author><author><name sortKey="Reiss, P" uniqKey="Reiss P">P Reiss</name></author><author><name sortKey="Thiebaut, R" uniqKey="Thiebaut R">R Thiebaut</name></author><author><name sortKey="Morfeldt, L" uniqKey="Morfeldt L">L Morfeldt</name></author><author><name sortKey="De Wit, S" uniqKey="De Wit S">S De Wit</name></author><author><name sortKey="Pradier, C" uniqKey="Pradier C">C Pradier</name></author><author><name sortKey="Calvo, G" uniqKey="Calvo G">G Calvo</name></author><author><name sortKey="Law, Mg" uniqKey="Law M">MG Law</name></author><author><name sortKey="Kirk, O" uniqKey="Kirk O">O Kirk</name></author><author><name sortKey="Phillips, An" uniqKey="Phillips A">AN Phillips</name></author><author><name sortKey="Lundgren, Jd" uniqKey="Lundgren J">JD Lundgren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neuhaus, J" uniqKey="Neuhaus J">J Neuhaus</name></author><author><name sortKey="Jacobs, Dr" uniqKey="Jacobs D">DR Jacobs</name></author><author><name sortKey="Baker, Jv" uniqKey="Baker J">JV Baker</name></author><author><name sortKey="Calmy, A" uniqKey="Calmy A">A Calmy</name></author><author><name sortKey="Duprez, D" uniqKey="Duprez D">D Duprez</name></author><author><name sortKey="La Rosa, A" uniqKey="La Rosa A">A La Rosa</name></author><author><name sortKey="Kuller, Lh" uniqKey="Kuller L">LH Kuller</name></author><author><name sortKey="Pett, Sl" uniqKey="Pett S">SL Pett</name></author><author><name sortKey="Ristola, M" uniqKey="Ristola M">M Ristola</name></author><author><name sortKey="Ross, Mj" uniqKey="Ross M">MJ Ross</name></author><author><name sortKey="Shlipak, Mg" uniqKey="Shlipak M">MG Shlipak</name></author><author><name sortKey="Tracy, R" uniqKey="Tracy R">R Tracy</name></author><author><name sortKey="Neaton, Jd" uniqKey="Neaton J">JD Neaton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Friis Moller, N" uniqKey="Friis Moller N">N Friis-Moller</name></author><author><name sortKey="Weber, R" uniqKey="Weber R">R Weber</name></author><author><name sortKey="Reiss, P" uniqKey="Reiss P">P Reiss</name></author><author><name sortKey="Thiebaut, R" uniqKey="Thiebaut R">R Thiebaut</name></author><author><name sortKey="Kirk, O" uniqKey="Kirk O">O Kirk</name></author><author><name sortKey="D Arminio Monforte, A" uniqKey="D Arminio Monforte A">A d'Arminio Monforte</name></author><author><name sortKey="Pradier, C" uniqKey="Pradier C">C Pradier</name></author><author><name sortKey="Morfeldt, L" uniqKey="Morfeldt L">L Morfeldt</name></author><author><name sortKey="Mateu, S" uniqKey="Mateu S">S Mateu</name></author><author><name sortKey="Law, M" uniqKey="Law M">M Law</name></author><author><name sortKey="El Sadr, W" uniqKey="El Sadr W">W El-Sadr</name></author><author><name sortKey="De Wit, S" uniqKey="De Wit S">S De Wit</name></author><author><name sortKey="Sabin, Ca" uniqKey="Sabin C">CA Sabin</name></author><author><name sortKey="Phillips, An" uniqKey="Phillips A">AN Phillips</name></author><author><name sortKey="Lundgren, Jd" uniqKey="Lundgren J">JD Lundgren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deeks, Sg" uniqKey="Deeks S">SG Deeks</name></author><author><name sortKey="Phillips, An" uniqKey="Phillips A">AN Phillips</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bongaarts, J" uniqKey="Bongaarts J">J Bongaarts</name></author><author><name sortKey="Over, M" uniqKey="Over M">M Over</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Abdool Karim, Q" uniqKey="Abdool Karim Q">Q Abdool Karim</name></author><author><name sortKey="Abdool Karim, Ss" uniqKey="Abdool Karim S">SS Abdool Karim</name></author><author><name sortKey="Frohlich, Ja" uniqKey="Frohlich J">JA Frohlich</name></author><author><name sortKey="Grobler, Ac" uniqKey="Grobler A">AC Grobler</name></author><author><name sortKey="Baxter, C" uniqKey="Baxter C">C Baxter</name></author><author><name sortKey="Mansoor, Le" uniqKey="Mansoor L">LE Mansoor</name></author><author><name sortKey="Kharsany, Ab" uniqKey="Kharsany A">AB Kharsany</name></author><author><name sortKey="Sibeko, S" uniqKey="Sibeko S">S Sibeko</name></author><author><name sortKey="Mlisana, Kp" uniqKey="Mlisana K">KP Mlisana</name></author><author><name sortKey="Omar, Z" uniqKey="Omar Z">Z Omar</name></author><author><name sortKey="Gengiah, Tn" uniqKey="Gengiah T">TN Gengiah</name></author><author><name sortKey="Maarschalk, S" uniqKey="Maarschalk S">S Maarschalk</name></author><author><name sortKey="Arulappan, N" uniqKey="Arulappan N">N Arulappan</name></author><author><name sortKey="Mlotshwa, M" uniqKey="Mlotshwa M">M Mlotshwa</name></author><author><name sortKey="Morris, L" uniqKey="Morris L">L Morris</name></author><author><name sortKey="Taylor, D" uniqKey="Taylor D">D Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Auvert, B" uniqKey="Auvert B">B Auvert</name></author><author><name sortKey="Taljaard, D" uniqKey="Taljaard D">D Taljaard</name></author><author><name sortKey="Lagarde, E" uniqKey="Lagarde E">E Lagarde</name></author><author><name sortKey="Sobngwi Tambekou, J" uniqKey="Sobngwi Tambekou J">J Sobngwi-Tambekou</name></author><author><name sortKey="Sitta, R" uniqKey="Sitta R">R Sitta</name></author><author><name sortKey="Puren, A" uniqKey="Puren A">A Puren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hecht, R" uniqKey="Hecht R">R Hecht</name></author><author><name sortKey="Bollinger, L" uniqKey="Bollinger L">L Bollinger</name></author><author><name sortKey="Stover, J" uniqKey="Stover J">J Stover</name></author><author><name sortKey="Mcgreevey, W" uniqKey="Mcgreevey W">W McGreevey</name></author><author><name sortKey="Muhib, F" uniqKey="Muhib F">F Muhib</name></author><author><name sortKey="Madavo, Ce" uniqKey="Madavo C">CE Madavo</name></author><author><name sortKey="De Ferranti, D" uniqKey="De Ferranti D">D de Ferranti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chun, Tw" uniqKey="Chun T">TW Chun</name></author><author><name sortKey="Carruth, L" uniqKey="Carruth L">L Carruth</name></author><author><name sortKey="Finzi, D" uniqKey="Finzi D">D Finzi</name></author><author><name sortKey="Shen, X" uniqKey="Shen X">X Shen</name></author><author><name sortKey="Digiuseppe, Ja" uniqKey="Digiuseppe J">JA DiGiuseppe</name></author><author><name sortKey="Taylor, H" uniqKey="Taylor H">H Taylor</name></author><author><name sortKey="Hermankova, M" uniqKey="Hermankova M">M Hermankova</name></author><author><name sortKey="Chadwick, K" uniqKey="Chadwick K">K Chadwick</name></author><author><name sortKey="Margolick, J" uniqKey="Margolick J">J Margolick</name></author><author><name sortKey="Quinn, Tc" uniqKey="Quinn T">TC Quinn</name></author><author><name sortKey="Kuo, Yh" uniqKey="Kuo Y">YH Kuo</name></author><author><name sortKey="Brookmeyer, R" uniqKey="Brookmeyer R">R Brookmeyer</name></author><author><name sortKey="Zeiger, Ma" uniqKey="Zeiger M">MA Zeiger</name></author><author><name sortKey="Barditch Crovo, P" uniqKey="Barditch Crovo P">P Barditch-Crovo</name></author><author><name sortKey="Siliciano, Rf" uniqKey="Siliciano R">RF Siliciano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Finzi, D" uniqKey="Finzi D">D Finzi</name></author><author><name sortKey="Blankson, J" uniqKey="Blankson J">J Blankson</name></author><author><name sortKey="Siliciano, J" uniqKey="Siliciano J">J Siliciano</name></author><author><name sortKey="Margolick, J" uniqKey="Margolick J">J Margolick</name></author><author><name sortKey="Chadwick, K" uniqKey="Chadwick K">K Chadwick</name></author><author><name sortKey="Pierson, T" uniqKey="Pierson T">T Pierson</name></author><author><name sortKey="Smith, K" uniqKey="Smith K">K Smith</name></author><author><name sortKey="Lisziewicz, J" uniqKey="Lisziewicz J">J Lisziewicz</name></author><author><name sortKey="Lori, F" uniqKey="Lori F">F Lori</name></author><author><name sortKey="Flexner, C" uniqKey="Flexner C">C Flexner</name></author><author><name sortKey="Quinn, T" uniqKey="Quinn T">T Quinn</name></author><author><name sortKey="Chaisson, R" uniqKey="Chaisson R">R Chaisson</name></author><author><name sortKey="Rosenberg, E" uniqKey="Rosenberg E">E Rosenberg</name></author><author><name sortKey="Walker, B" uniqKey="Walker B">B Walker</name></author><author><name sortKey="Gange, S" uniqKey="Gange S">S Gange</name></author><author><name sortKey="Gallant, J" uniqKey="Gallant J">J Gallant</name></author><author><name sortKey="Siliciano, R" uniqKey="Siliciano R">R Siliciano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, J" uniqKey="Wong J">J Wong</name></author><author><name sortKey="Hezareh, M" uniqKey="Hezareh M">M Hezareh</name></author><author><name sortKey="Gunthard, H" uniqKey="Gunthard H">H Gunthard</name></author><author><name sortKey="Havlir, D" uniqKey="Havlir D">D Havlir</name></author><author><name sortKey="Ignacio, C" uniqKey="Ignacio C">C Ignacio</name></author><author><name sortKey="Spina, C" uniqKey="Spina C">C Spina</name></author><author><name sortKey="Richman, D" uniqKey="Richman D">D Richman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palmer, S" uniqKey="Palmer S">S Palmer</name></author><author><name sortKey="Maldarelli, F" uniqKey="Maldarelli F">F Maldarelli</name></author><author><name sortKey="Wiegand, A" uniqKey="Wiegand A">A Wiegand</name></author><author><name sortKey="Bernstein, B" uniqKey="Bernstein B">B Bernstein</name></author><author><name sortKey="Hanna, Gj" uniqKey="Hanna G">GJ Hanna</name></author><author><name sortKey="Brun, Sc" uniqKey="Brun S">SC Brun</name></author><author><name sortKey="Kempf, Dj" uniqKey="Kempf D">DJ Kempf</name></author><author><name sortKey="Mellors, Jw" uniqKey="Mellors J">JW Mellors</name></author><author><name sortKey="Coffin, Jm" uniqKey="Coffin J">JM Coffin</name></author><author><name sortKey="King, Ms" uniqKey="King M">MS King</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maldarelli, F" uniqKey="Maldarelli F">F Maldarelli</name></author><author><name sortKey="Palmer, S" uniqKey="Palmer S">S Palmer</name></author><author><name sortKey="King, Ms" uniqKey="King M">MS King</name></author><author><name sortKey="Wiegand, A" uniqKey="Wiegand A">A Wiegand</name></author><author><name sortKey="Polis, Ma" uniqKey="Polis M">MA Polis</name></author><author><name sortKey="Mican, J" uniqKey="Mican J">J Mican</name></author><author><name sortKey="Kovacs, Ja" uniqKey="Kovacs J">JA Kovacs</name></author><author><name sortKey="Davey, Rt" uniqKey="Davey R">RT Davey</name></author><author><name sortKey="Rock Kress, D" uniqKey="Rock Kress D">D Rock-Kress</name></author><author><name sortKey="Dewar, R" uniqKey="Dewar R">R Dewar</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name></author><author><name sortKey="Metcalf, Ja" uniqKey="Metcalf J">JA Metcalf</name></author><author><name sortKey="Rehm, C" uniqKey="Rehm C">C Rehm</name></author><author><name sortKey="Brun, Sc" uniqKey="Brun S">SC Brun</name></author><author><name sortKey="Hanna, Gj" uniqKey="Hanna G">GJ Hanna</name></author><author><name sortKey="Kempf, Dj" uniqKey="Kempf D">DJ Kempf</name></author><author><name sortKey="Coffin, Jm" uniqKey="Coffin J">JM Coffin</name></author><author><name sortKey="Mellors, Jw" uniqKey="Mellors J">JW Mellors</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sonza, S" uniqKey="Sonza S">S Sonza</name></author><author><name sortKey="Mutimer, Hp" uniqKey="Mutimer H">HP Mutimer</name></author><author><name sortKey="Oelrichs, R" uniqKey="Oelrichs R">R Oelrichs</name></author><author><name sortKey="Jardine, D" uniqKey="Jardine D">D Jardine</name></author><author><name sortKey="Harvey, K" uniqKey="Harvey K">K Harvey</name></author><author><name sortKey="Dunne, A" uniqKey="Dunne A">A Dunne</name></author><author><name sortKey="Purcell, Df" uniqKey="Purcell D">DF Purcell</name></author><author><name sortKey="Birch, C" uniqKey="Birch C">C Birch</name></author><author><name sortKey="Crowe, Sm" uniqKey="Crowe S">SM Crowe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gorry, P" uniqKey="Gorry P">P Gorry</name></author><author><name sortKey="Purcell, D" uniqKey="Purcell D">D Purcell</name></author><author><name sortKey="Howard, J" uniqKey="Howard J">J Howard</name></author><author><name sortKey="Mcphee, D" uniqKey="Mcphee D">D McPhee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Churchill, Mj" uniqKey="Churchill M">MJ Churchill</name></author><author><name sortKey="Wesselingh, Sl" uniqKey="Wesselingh S">SL Wesselingh</name></author><author><name sortKey="Cowley, D" uniqKey="Cowley D">D Cowley</name></author><author><name sortKey="Pardo, Ca" uniqKey="Pardo C">CA Pardo</name></author><author><name sortKey="Mcarthur, Jc" uniqKey="Mcarthur J">JC McArthur</name></author><author><name sortKey="Brew, Bj" uniqKey="Brew B">BJ Brew</name></author><author><name sortKey="Gorry, Pr" uniqKey="Gorry P">PR Gorry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zack, Ja" uniqKey="Zack J">JA Zack</name></author><author><name sortKey="Haislip, Am" uniqKey="Haislip A">AM Haislip</name></author><author><name sortKey="Krogstad, P" uniqKey="Krogstad P">P Krogstad</name></author><author><name sortKey="Chen, Is" uniqKey="Chen I">IS Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chomont, N" uniqKey="Chomont N">N Chomont</name></author><author><name sortKey="El Far, M" uniqKey="El Far M">M El-Far</name></author><author><name sortKey="Ancuta, P" uniqKey="Ancuta P">P Ancuta</name></author><author><name sortKey="Trautmann, L" uniqKey="Trautmann L">L Trautmann</name></author><author><name sortKey="Procopio, Fa" uniqKey="Procopio F">FA Procopio</name></author><author><name sortKey="Yassine Diab, B" uniqKey="Yassine Diab B">B Yassine-Diab</name></author><author><name sortKey="Boucher, G" uniqKey="Boucher G">G Boucher</name></author><author><name sortKey="Boulassel, Mr" uniqKey="Boulassel M">MR Boulassel</name></author><author><name sortKey="Ghattas, G" uniqKey="Ghattas G">G Ghattas</name></author><author><name sortKey="Brenchley, Jm" uniqKey="Brenchley J">JM Brenchley</name></author><author><name sortKey="Schacker, Tw" uniqKey="Schacker T">TW Schacker</name></author><author><name sortKey="Hill, Bj" uniqKey="Hill B">BJ Hill</name></author><author><name sortKey="Douek, Dc" uniqKey="Douek D">DC Douek</name></author><author><name sortKey="Routy, Jp" uniqKey="Routy J">JP Routy</name></author><author><name sortKey="Haddad, Ek" uniqKey="Haddad E">EK Haddad</name></author><author><name sortKey="Sekaly, Rp" uniqKey="Sekaly R">RP Sekaly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Finzi, D" uniqKey="Finzi D">D Finzi</name></author><author><name sortKey="Hermankova, M" uniqKey="Hermankova M">M Hermankova</name></author><author><name sortKey="Pierson, T" uniqKey="Pierson T">T Pierson</name></author><author><name sortKey="Carruth, L" uniqKey="Carruth L">L Carruth</name></author><author><name sortKey="Buck, C" uniqKey="Buck C">C Buck</name></author><author><name sortKey="Chaisson, R" uniqKey="Chaisson R">R Chaisson</name></author><author><name sortKey="Quinn, T" uniqKey="Quinn T">T Quinn</name></author><author><name sortKey="Chadwick, K" uniqKey="Chadwick K">K Chadwick</name></author><author><name sortKey="Margolick, J" uniqKey="Margolick J">J Margolick</name></author><author><name sortKey="Brookmeyer, R" uniqKey="Brookmeyer R">R Brookmeyer</name></author><author><name sortKey="Gallant, J" uniqKey="Gallant J">J Gallant</name></author><author><name sortKey="Markowitz, M" uniqKey="Markowitz M">M Markowitz</name></author><author><name sortKey="Ho, D" uniqKey="Ho D">D Ho</name></author><author><name sortKey="Richman, D" uniqKey="Richman D">D Richman</name></author><author><name sortKey="Silicano, R" uniqKey="Silicano R">R Silicano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siliciano, Jd" uniqKey="Siliciano J">JD Siliciano</name></author><author><name sortKey="Kajdas, J" uniqKey="Kajdas J">J Kajdas</name></author><author><name sortKey="Finzi, D" uniqKey="Finzi D">D Finzi</name></author><author><name sortKey="Quinn, Tc" uniqKey="Quinn T">TC Quinn</name></author><author><name sortKey="Chadwick, K" uniqKey="Chadwick K">K Chadwick</name></author><author><name sortKey="Margolick, Jb" uniqKey="Margolick J">JB Margolick</name></author><author><name sortKey="Kovacs, C" uniqKey="Kovacs C">C Kovacs</name></author><author><name sortKey="Gange, Sj" uniqKey="Gange S">SJ Gange</name></author><author><name sortKey="Siliciano, Rf" uniqKey="Siliciano R">RF Siliciano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zack, J" uniqKey="Zack J">J Zack</name></author><author><name sortKey="Arrigo, S" uniqKey="Arrigo S">S Arrigo</name></author><author><name sortKey="Weitsman, S" uniqKey="Weitsman S">S Weitsman</name></author><author><name sortKey="Go, A" uniqKey="Go A">A Go</name></author><author><name sortKey="Haislip, A" uniqKey="Haislip A">A Haislip</name></author><author><name sortKey="Chen, I" uniqKey="Chen I">I Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bukrinsky, Mi" uniqKey="Bukrinsky M">MI Bukrinsky</name></author><author><name sortKey="Sharova, N" uniqKey="Sharova N">N Sharova</name></author><author><name sortKey="Dempsey, Mp" uniqKey="Dempsey M">MP Dempsey</name></author><author><name sortKey="Stanwick, Tl" uniqKey="Stanwick T">TL Stanwick</name></author><author><name sortKey="Bukrinskaya, Ag" uniqKey="Bukrinskaya A">AG Bukrinskaya</name></author><author><name sortKey="Haggerty, S" uniqKey="Haggerty S">S Haggerty</name></author><author><name sortKey="Stevenson, M" uniqKey="Stevenson M">M Stevenson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Musey, Lk" uniqKey="Musey L">LK Musey</name></author><author><name sortKey="Krieger, Jn" uniqKey="Krieger J">JN Krieger</name></author><author><name sortKey="Hughes, Jp" uniqKey="Hughes J">JP Hughes</name></author><author><name sortKey="Schacker, Tw" uniqKey="Schacker T">TW Schacker</name></author><author><name sortKey="Corey, L" uniqKey="Corey L">L Corey</name></author><author><name sortKey="Mcelrath, Mj" uniqKey="Mcelrath M">MJ McElrath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name></author><author><name sortKey="Schuler, T" uniqKey="Schuler T">T Schuler</name></author><author><name sortKey="Zupancic, M" uniqKey="Zupancic M">M Zupancic</name></author><author><name sortKey="Wietgrefe, S" uniqKey="Wietgrefe S">S Wietgrefe</name></author><author><name sortKey="Staskus, Ka" uniqKey="Staskus K">KA Staskus</name></author><author><name sortKey="Reimann, Ka" uniqKey="Reimann K">KA Reimann</name></author><author><name sortKey="Reinhart, Ta" uniqKey="Reinhart T">TA Reinhart</name></author><author><name sortKey="Rogan, M" uniqKey="Rogan M">M Rogan</name></author><author><name sortKey="Cavert, W" uniqKey="Cavert W">W Cavert</name></author><author><name sortKey="Miller, Cj" uniqKey="Miller C">CJ Miller</name></author><author><name sortKey="Veazey, Rs" uniqKey="Veazey R">RS Veazey</name></author><author><name sortKey="Notermans, D" uniqKey="Notermans D">D Notermans</name></author><author><name sortKey="Little, S" uniqKey="Little S">S Little</name></author><author><name sortKey="Danner, Sa" uniqKey="Danner S">SA Danner</name></author><author><name sortKey="Richman, Dd" uniqKey="Richman D">DD Richman</name></author><author><name sortKey="Havlir, D" uniqKey="Havlir D">D Havlir</name></author><author><name sortKey="Wong, J" uniqKey="Wong J">J Wong</name></author><author><name sortKey="Jordan, Hl" uniqKey="Jordan H">HL Jordan</name></author><author><name sortKey="Schacker, Tw" uniqKey="Schacker T">TW Schacker</name></author><author><name sortKey="Racz, P" uniqKey="Racz P">P Racz</name></author><author><name sortKey="Tenner Racz, K" uniqKey="Tenner Racz K">K Tenner-Racz</name></author><author><name sortKey="Letvin, Nl" uniqKey="Letvin N">NL Letvin</name></author><author><name sortKey="Wolinsky, S" uniqKey="Wolinsky S">S Wolinsky</name></author><author><name sortKey="Haase, At" uniqKey="Haase A">AT Haase</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Audige, A" uniqKey="Audige A">A Audige</name></author><author><name sortKey="Schlaepfer, E" uniqKey="Schlaepfer E">E Schlaepfer</name></author><author><name sortKey="Bonanomi, A" uniqKey="Bonanomi A">A Bonanomi</name></author><author><name sortKey="Joller, H" uniqKey="Joller H">H Joller</name></author><author><name sortKey="Knuchel, Mc" uniqKey="Knuchel M">MC Knuchel</name></author><author><name sortKey="Weber, M" uniqKey="Weber M">M Weber</name></author><author><name sortKey="Nadal, D" uniqKey="Nadal D">D Nadal</name></author><author><name sortKey="Speck, Rf" uniqKey="Speck R">RF Speck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eckstein, Da" uniqKey="Eckstein D">DA Eckstein</name></author><author><name sortKey="Penn, Ml" uniqKey="Penn M">ML Penn</name></author><author><name sortKey="Korin, Yd" uniqKey="Korin Y">YD Korin</name></author><author><name sortKey="Scripture Adams, Dd" uniqKey="Scripture Adams D">DD Scripture-Adams</name></author><author><name sortKey="Zack, Ja" uniqKey="Zack J">JA Zack</name></author><author><name sortKey="Kreisberg, Jf" uniqKey="Kreisberg J">JF Kreisberg</name></author><author><name sortKey="Roederer, M" uniqKey="Roederer M">M Roederer</name></author><author><name sortKey="Sherman, Mp" uniqKey="Sherman M">MP Sherman</name></author><author><name sortKey="Chin, Ps" uniqKey="Chin P">PS Chin</name></author><author><name sortKey="Goldsmith, Ma" uniqKey="Goldsmith M">MA Goldsmith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saleh, S" uniqKey="Saleh S">S Saleh</name></author><author><name sortKey="Solomon, A" uniqKey="Solomon A">A Solomon</name></author><author><name sortKey="Wightman, F" uniqKey="Wightman F">F Wightman</name></author><author><name sortKey="Xhilaga, M" uniqKey="Xhilaga M">M Xhilaga</name></author><author><name sortKey="Cameron, Pu" uniqKey="Cameron P">PU Cameron</name></author><author><name sortKey="Lewin, Sr" uniqKey="Lewin S">SR Lewin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cameron, P" uniqKey="Cameron P">P Cameron</name></author><author><name sortKey="Saleh, S" uniqKey="Saleh S">S Saleh</name></author><author><name sortKey="Sallmann, G" uniqKey="Sallmann G">G Sallmann</name></author><author><name sortKey="Solomon, A" uniqKey="Solomon A">A Solomon</name></author><author><name sortKey="Wightman, F" uniqKey="Wightman F">F Wightman</name></author><author><name sortKey="Evans, V" uniqKey="Evans V">V Evans</name></author><author><name sortKey="Boucher, G" uniqKey="Boucher G">G Boucher</name></author><author><name sortKey="Haddad, E" uniqKey="Haddad E">E Haddad</name></author><author><name sortKey="Sekaly, R" uniqKey="Sekaly R">R Sekaly</name></author><author><name sortKey="Harman, A" uniqKey="Harman A">A Harman</name></author><author><name sortKey="Anderson, J" uniqKey="Anderson J">J Anderson</name></author><author><name sortKey="Jones, K" uniqKey="Jones K">K Jones</name></author><author><name sortKey="Mak, J" uniqKey="Mak J">J Mak</name></author><author><name sortKey="Cunningham, A" uniqKey="Cunningham A">A Cunningham</name></author><author><name sortKey="Jaworowski, A" uniqKey="Jaworowski A">A Jaworowski</name></author><author><name sortKey="Lewin, S" uniqKey="Lewin S">S Lewin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosque, A" uniqKey="Bosque A">A Bosque</name></author><author><name sortKey="Planelles, V" uniqKey="Planelles V">V Planelles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marini, A" uniqKey="Marini A">A Marini</name></author><author><name sortKey="Harper, Jm" uniqKey="Harper J">JM Harper</name></author><author><name sortKey="Romerio, F" uniqKey="Romerio F">F Romerio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Hc" uniqKey="Yang H">HC Yang</name></author><author><name sortKey="Xing, S" uniqKey="Xing S">S Xing</name></author><author><name sortKey="Shan, L" uniqKey="Shan L">L Shan</name></author><author><name sortKey="O Connell, K" uniqKey="O Connell K">K O'Connell</name></author><author><name sortKey="Dinoso, J" uniqKey="Dinoso J">J Dinoso</name></author><author><name sortKey="Shen, A" uniqKey="Shen A">A Shen</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Shrum, Ck" uniqKey="Shrum C">CK Shrum</name></author><author><name sortKey="Han, Y" uniqKey="Han Y">Y Han</name></author><author><name sortKey="Liu, Jo" uniqKey="Liu J">JO Liu</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Margolick, Jb" uniqKey="Margolick J">JB Margolick</name></author><author><name sortKey="Siliciano, Rf" uniqKey="Siliciano R">RF Siliciano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Finzi, D" uniqKey="Finzi D">D Finzi</name></author><author><name sortKey="Blankson, J" uniqKey="Blankson J">J Blankson</name></author><author><name sortKey="Siliciano, Jd" uniqKey="Siliciano J">JD Siliciano</name></author><author><name sortKey="Margolick, Jb" uniqKey="Margolick J">JB Margolick</name></author><author><name sortKey="Chadwick, K" uniqKey="Chadwick K">K Chadwick</name></author><author><name sortKey="Pierson, T" uniqKey="Pierson T">T Pierson</name></author><author><name sortKey="Smith, K" uniqKey="Smith K">K Smith</name></author><author><name sortKey="Lisziewicz, J" uniqKey="Lisziewicz J">J Lisziewicz</name></author><author><name sortKey="Lori, F" uniqKey="Lori F">F Lori</name></author><author><name sortKey="Flexner, C" uniqKey="Flexner C">C Flexner</name></author><author><name sortKey="Quinn, Tc" uniqKey="Quinn T">TC Quinn</name></author><author><name sortKey="Chaisson, Re" uniqKey="Chaisson R">RE Chaisson</name></author><author><name sortKey="Rosenberg, E" uniqKey="Rosenberg E">E Rosenberg</name></author><author><name sortKey="Walker, B" uniqKey="Walker B">B Walker</name></author><author><name sortKey="Gange, S" uniqKey="Gange S">S Gange</name></author><author><name sortKey="Gallant, J" uniqKey="Gallant J">J Gallant</name></author><author><name sortKey="Siliciano, Rf" uniqKey="Siliciano R">RF Siliciano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brooks, D" uniqKey="Brooks D">D Brooks</name></author><author><name sortKey="Kitchen, S" uniqKey="Kitchen S">S Kitchen</name></author><author><name sortKey="Kitchen, C" uniqKey="Kitchen C">C Kitchen</name></author><author><name sortKey="Scripture Adams, D" uniqKey="Scripture Adams D">D Scripture-Adams</name></author><author><name sortKey="Zack, J" uniqKey="Zack J">J Zack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carter, Cc" uniqKey="Carter C">CC Carter</name></author><author><name sortKey="Onafuwa Nuga, A" uniqKey="Onafuwa Nuga A">A Onafuwa-Nuga</name></author><author><name sortKey="Mcnamara, La" uniqKey="Mcnamara L">LA McNamara</name></author><author><name sortKey="Riddell, Jt" uniqKey="Riddell J">Jt Riddell</name></author><author><name sortKey="Bixby, D" uniqKey="Bixby D">D Bixby</name></author><author><name sortKey="Savona, Mr" uniqKey="Savona M">MR Savona</name></author><author><name sortKey="Collins, Kl" uniqKey="Collins K">KL Collins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wightman, F" uniqKey="Wightman F">F Wightman</name></author><author><name sortKey="Solomon, A" uniqKey="Solomon A">A Solomon</name></author><author><name sortKey="Khoury, G" uniqKey="Khoury G">G Khoury</name></author><author><name sortKey="Green, J" uniqKey="Green J">J Green</name></author><author><name sortKey="Gray, L" uniqKey="Gray L">L Gray</name></author><author><name sortKey="Gorry, P" uniqKey="Gorry P">P Gorry</name></author><author><name sortKey="Ho, Y" uniqKey="Ho Y">Y Ho</name></author><author><name sortKey="Saksena, N" uniqKey="Saksena N">N Saksena</name></author><author><name sortKey="Hoy, J" uniqKey="Hoy J">J Hoy</name></author><author><name sortKey="Crowe, S" uniqKey="Crowe S">S Crowe</name></author><author><name sortKey="Cameron, P" uniqKey="Cameron P">P Cameron</name></author><author><name sortKey="Lewin, S" uniqKey="Lewin S">S Lewin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sedaghat, Ar" uniqKey="Sedaghat A">AR Sedaghat</name></author><author><name sortKey="Siliciano, Jd" uniqKey="Siliciano J">JD Siliciano</name></author><author><name sortKey="Brennan, Tp" uniqKey="Brennan T">TP Brennan</name></author><author><name sortKey="Wilke, Co" uniqKey="Wilke C">CO Wilke</name></author><author><name sortKey="Siliciano, Rf" uniqKey="Siliciano R">RF Siliciano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brennan, Tp" uniqKey="Brennan T">TP Brennan</name></author><author><name sortKey="Woods, Jo" uniqKey="Woods J">JO Woods</name></author><author><name sortKey="Sedaghat, Ar" uniqKey="Sedaghat A">AR Sedaghat</name></author><author><name sortKey="Siliciano, Jd" uniqKey="Siliciano J">JD Siliciano</name></author><author><name sortKey="Siliciano, Rf" uniqKey="Siliciano R">RF Siliciano</name></author><author><name sortKey="Wilke, Co" uniqKey="Wilke C">CO Wilke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hermankova, M" uniqKey="Hermankova M">M Hermankova</name></author><author><name sortKey="Ray, Sc" uniqKey="Ray S">SC Ray</name></author><author><name sortKey="Ruff, C" uniqKey="Ruff C">C Ruff</name></author><author><name sortKey="Powell Davis, M" uniqKey="Powell Davis M">M Powell-Davis</name></author><author><name sortKey="Ingersoll, R" uniqKey="Ingersoll R">R Ingersoll</name></author><author><name sortKey="D Aquila, Rt" uniqKey="D Aquila R">RT D'Aquila</name></author><author><name sortKey="Quinn, Tc" uniqKey="Quinn T">TC Quinn</name></author><author><name sortKey="Siliciano, Jd" uniqKey="Siliciano J">JD Siliciano</name></author><author><name sortKey="Siliciano, Rf" uniqKey="Siliciano R">RF Siliciano</name></author><author><name sortKey="Persaud, D" uniqKey="Persaud D">D Persaud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Persaud, D" uniqKey="Persaud D">D Persaud</name></author><author><name sortKey="Siberry, Gk" uniqKey="Siberry G">GK Siberry</name></author><author><name sortKey="Ahonkhai, A" uniqKey="Ahonkhai A">A Ahonkhai</name></author><author><name sortKey="Kajdas, J" uniqKey="Kajdas J">J Kajdas</name></author><author><name sortKey="Monie, D" uniqKey="Monie D">D Monie</name></author><author><name sortKey="Hutton, N" uniqKey="Hutton N">N Hutton</name></author><author><name sortKey="Watson, Dc" uniqKey="Watson D">DC Watson</name></author><author><name sortKey="Quinn, Tc" uniqKey="Quinn T">TC Quinn</name></author><author><name sortKey="Ray, Sc" uniqKey="Ray S">SC Ray</name></author><author><name sortKey="Siliciano, Rf" uniqKey="Siliciano R">RF Siliciano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Churchill, Mj" uniqKey="Churchill M">MJ Churchill</name></author><author><name sortKey="Gorry, Pr" uniqKey="Gorry P">PR Gorry</name></author><author><name sortKey="Cowley, D" uniqKey="Cowley D">D Cowley</name></author><author><name sortKey="Lal, L" uniqKey="Lal L">L Lal</name></author><author><name sortKey="Sonza, S" uniqKey="Sonza S">S Sonza</name></author><author><name sortKey="Purcell, Df" uniqKey="Purcell D">DF Purcell</name></author><author><name sortKey="Thompson, Ka" uniqKey="Thompson K">KA Thompson</name></author><author><name sortKey="Gabuzda, D" uniqKey="Gabuzda D">D Gabuzda</name></author><author><name sortKey="Mcarthur, Jc" uniqKey="Mcarthur J">JC McArthur</name></author><author><name sortKey="Pardo, Ca" uniqKey="Pardo C">CA Pardo</name></author><author><name sortKey="Wesselingh, Sl" uniqKey="Wesselingh S">SL Wesselingh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chun, Tw" uniqKey="Chun T">TW Chun</name></author><author><name sortKey="Nickle, Dc" uniqKey="Nickle D">DC Nickle</name></author><author><name sortKey="Justement, Js" uniqKey="Justement J">JS Justement</name></author><author><name sortKey="Meyers, Jh" uniqKey="Meyers J">JH Meyers</name></author><author><name sortKey="Roby, G" uniqKey="Roby G">G Roby</name></author><author><name sortKey="Hallahan, Cw" uniqKey="Hallahan C">CW Hallahan</name></author><author><name sortKey="Kottilil, S" uniqKey="Kottilil S">S Kottilil</name></author><author><name sortKey="Moir, S" uniqKey="Moir S">S Moir</name></author><author><name sortKey="Mican, Jm" uniqKey="Mican J">JM Mican</name></author><author><name sortKey="Mullins, Ji" uniqKey="Mullins J">JI Mullins</name></author><author><name sortKey="Ward, Dj" uniqKey="Ward D">DJ Ward</name></author><author><name sortKey="Kovacs, Ja" uniqKey="Kovacs J">JA Kovacs</name></author><author><name sortKey="Mannon, Pj" uniqKey="Mannon P">PJ Mannon</name></author><author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halfon, P" uniqKey="Halfon P">P Halfon</name></author><author><name sortKey="Giorgetti, C" uniqKey="Giorgetti C">C Giorgetti</name></author><author><name sortKey="Khiri, H" uniqKey="Khiri H">H Khiri</name></author><author><name sortKey="Penaranda, G" uniqKey="Penaranda G">G Penaranda</name></author><author><name sortKey="Terriou, P" uniqKey="Terriou P">P Terriou</name></author><author><name sortKey="Porcu Buisson, G" uniqKey="Porcu Buisson G">G Porcu-Buisson</name></author><author><name sortKey="Chabert Orsini, V" uniqKey="Chabert Orsini V">V Chabert-Orsini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yukl, Sa" uniqKey="Yukl S">SA Yukl</name></author><author><name sortKey="Gianella, S" uniqKey="Gianella S">S Gianella</name></author><author><name sortKey="Sinclair, E" uniqKey="Sinclair E">E Sinclair</name></author><author><name sortKey="Epling, L" uniqKey="Epling L">L Epling</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author><author><name sortKey="Duan, L" uniqKey="Duan L">L Duan</name></author><author><name sortKey="Choi, Al" uniqKey="Choi A">AL Choi</name></author><author><name sortKey="Girling, V" uniqKey="Girling V">V Girling</name></author><author><name sortKey="Ho, T" uniqKey="Ho T">T Ho</name></author><author><name sortKey="Li, P" uniqKey="Li P">P Li</name></author><author><name sortKey="Fujimoto, K" uniqKey="Fujimoto K">K Fujimoto</name></author><author><name sortKey="Lampiris, H" uniqKey="Lampiris H">H Lampiris</name></author><author><name sortKey="Hare, Cb" uniqKey="Hare C">CB Hare</name></author><author><name sortKey="Pandori, M" uniqKey="Pandori M">M Pandori</name></author><author><name sortKey="Haase, At" uniqKey="Haase A">AT Haase</name></author><author><name sortKey="Gunthard, Hf" uniqKey="Gunthard H">HF Günthard</name></author><author><name sortKey="Fischer, M" uniqKey="Fischer M">M Fischer</name></author><author><name sortKey="Shergill, Ak" uniqKey="Shergill A">AK Shergill</name></author><author><name sortKey="Mcquaid, K" uniqKey="Mcquaid K">K McQuaid</name></author><author><name sortKey="Havlir, Dv" uniqKey="Havlir D">DV Havlir</name></author><author><name sortKey="Wong, Jk" uniqKey="Wong J">JK Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hutter, G" uniqKey="Hutter G">G Hutter</name></author><author><name sortKey="Nowak, D" uniqKey="Nowak D">D Nowak</name></author><author><name sortKey="Mossner, M" uniqKey="Mossner M">M Mossner</name></author><author><name sortKey="Ganepola, S" uniqKey="Ganepola S">S Ganepola</name></author><author><name sortKey="Mussig, A" uniqKey="Mussig A">A Mussig</name></author><author><name sortKey="Allers, K" uniqKey="Allers K">K Allers</name></author><author><name sortKey="Schneider, T" uniqKey="Schneider T">T Schneider</name></author><author><name sortKey="Hofmann, J" uniqKey="Hofmann J">J Hofmann</name></author><author><name sortKey="Kucherer, C" uniqKey="Kucherer C">C Kucherer</name></author><author><name sortKey="Blau, O" uniqKey="Blau O">O Blau</name></author><author><name sortKey="Blau, Iw" uniqKey="Blau I">IW Blau</name></author><author><name sortKey="Hofmann, Wk" uniqKey="Hofmann W">WK Hofmann</name></author><author><name sortKey="Thiel, E" uniqKey="Thiel E">E Thiel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deeks, Sg" uniqKey="Deeks S">SG Deeks</name></author><author><name sortKey="Walker, Bd" uniqKey="Walker B">BD Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hunt, Pw" uniqKey="Hunt P">PW Hunt</name></author><author><name sortKey="Brenchley, J" uniqKey="Brenchley J">J Brenchley</name></author><author><name sortKey="Sinclair, E" uniqKey="Sinclair E">E Sinclair</name></author><author><name sortKey="Mccune, Jm" uniqKey="Mccune J">JM McCune</name></author><author><name sortKey="Roland, M" uniqKey="Roland M">M Roland</name></author><author><name sortKey="Page Shafer, K" uniqKey="Page Shafer K">K Page-Shafer</name></author><author><name sortKey="Hsue, P" uniqKey="Hsue P">P Hsue</name></author><author><name sortKey="Emu, B" uniqKey="Emu B">B Emu</name></author><author><name sortKey="Krone, M" uniqKey="Krone M">M Krone</name></author><author><name sortKey="Lampiris, H" uniqKey="Lampiris H">H Lampiris</name></author><author><name sortKey="Douek, D" uniqKey="Douek D">D Douek</name></author><author><name sortKey="Martin, Jn" uniqKey="Martin J">JN Martin</name></author><author><name sortKey="Deeks, Sg" uniqKey="Deeks S">SG Deeks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hatano, H" uniqKey="Hatano H">H Hatano</name></author><author><name sortKey="Delwart, El" uniqKey="Delwart E">EL Delwart</name></author><author><name sortKey="Norris, Pj" uniqKey="Norris P">PJ Norris</name></author><author><name sortKey="Lee, Th" uniqKey="Lee T">TH Lee</name></author><author><name sortKey="Dunn Williams, J" uniqKey="Dunn Williams J">J Dunn-Williams</name></author><author><name sortKey="Hunt, Pw" uniqKey="Hunt P">PW Hunt</name></author><author><name sortKey="Hoh, R" uniqKey="Hoh R">R Hoh</name></author><author><name sortKey="Stramer, Sl" uniqKey="Stramer S">SL Stramer</name></author><author><name sortKey="Linnen, Jm" uniqKey="Linnen J">JM Linnen</name></author><author><name sortKey="Mccune, Jm" uniqKey="Mccune J">JM McCune</name></author><author><name sortKey="Martin, Jn" uniqKey="Martin J">JN Martin</name></author><author><name sortKey="Busch, Mp" uniqKey="Busch M">MP Busch</name></author><author><name sortKey="Deeks, Sg" uniqKey="Deeks S">SG Deeks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pereyra, F" uniqKey="Pereyra F">F Pereyra</name></author><author><name sortKey="Palmer, S" uniqKey="Palmer S">S Palmer</name></author><author><name sortKey="Miura, T" uniqKey="Miura T">T Miura</name></author><author><name sortKey="Block, Bl" uniqKey="Block B">BL Block</name></author><author><name sortKey="Wiegand, A" uniqKey="Wiegand A">A Wiegand</name></author><author><name sortKey="Rothchild, Ac" uniqKey="Rothchild A">AC Rothchild</name></author><author><name sortKey="Baker, B" uniqKey="Baker B">B Baker</name></author><author><name sortKey="Rosenberg, R" uniqKey="Rosenberg R">R Rosenberg</name></author><author><name sortKey="Cutrell, E" uniqKey="Cutrell E">E Cutrell</name></author><author><name sortKey="Seaman, Ms" uniqKey="Seaman M">MS Seaman</name></author><author><name sortKey="Coffin, Jm" uniqKey="Coffin J">JM Coffin</name></author><author><name sortKey="Walker, Bd" uniqKey="Walker B">BD Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Autran, B" uniqKey="Autran B">B Autran</name></author><author><name sortKey="Murphy, Rl" uniqKey="Murphy R">RL Murphy</name></author><author><name sortKey="Costagliola, D" uniqKey="Costagliola D">D Costagliola</name></author><author><name sortKey="Tubiana, R" uniqKey="Tubiana R">R Tubiana</name></author><author><name sortKey="Clotet, B" uniqKey="Clotet B">B Clotet</name></author><author><name sortKey="Gatell, J" uniqKey="Gatell J">J Gatell</name></author><author><name sortKey="Staszewski, S" uniqKey="Staszewski S">S Staszewski</name></author><author><name sortKey="Wincker, N" uniqKey="Wincker N">N Wincker</name></author><author><name sortKey="Assoumou, L" uniqKey="Assoumou L">L Assoumou</name></author><author><name sortKey="El Habib, R" uniqKey="El Habib R">R El-Habib</name></author><author><name sortKey="Calvez, V" uniqKey="Calvez V">V Calvez</name></author><author><name sortKey="Walker, B" uniqKey="Walker B">B Walker</name></author><author><name sortKey="Katlama, C" uniqKey="Katlama C">C Katlama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Connell, Ka" uniqKey="O Connell K">KA O'Connell</name></author><author><name sortKey="Brennan, Tp" uniqKey="Brennan T">TP Brennan</name></author><author><name sortKey="Bailey, Jr" uniqKey="Bailey J">JR Bailey</name></author><author><name sortKey="Ray, Sc" uniqKey="Ray S">SC Ray</name></author><author><name sortKey="Siliciano, Rf" uniqKey="Siliciano R">RF Siliciano</name></author><author><name sortKey="Blankson, Jn" uniqKey="Blankson J">JN Blankson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dinoso, Jb" uniqKey="Dinoso J">JB Dinoso</name></author><author><name sortKey="Kim, Sy" uniqKey="Kim S">SY Kim</name></author><author><name sortKey="Wiegand, Am" uniqKey="Wiegand A">AM Wiegand</name></author><author><name sortKey="Palmer, Se" uniqKey="Palmer S">SE Palmer</name></author><author><name sortKey="Gange, Sj" uniqKey="Gange S">SJ Gange</name></author><author><name sortKey="Cranmer, L" uniqKey="Cranmer L">L Cranmer</name></author><author><name sortKey="O Shea, A" uniqKey="O Shea A">A O'Shea</name></author><author><name sortKey="Callender, M" uniqKey="Callender M">M Callender</name></author><author><name sortKey="Spivak, A" uniqKey="Spivak A">A Spivak</name></author><author><name sortKey="Brennan, T" uniqKey="Brennan T">T Brennan</name></author><author><name sortKey="Kearney, Mf" uniqKey="Kearney M">MF Kearney</name></author><author><name sortKey="Proschan, Ma" uniqKey="Proschan M">MA Proschan</name></author><author><name sortKey="Mican, Jm" uniqKey="Mican J">JM Mican</name></author><author><name sortKey="Rehm, Ca" uniqKey="Rehm C">CA Rehm</name></author><author><name sortKey="Coffin, Jm" uniqKey="Coffin J">JM Coffin</name></author><author><name sortKey="Mellors, Jw" uniqKey="Mellors J">JW Mellors</name></author><author><name sortKey="Siliciano, Rf" uniqKey="Siliciano R">RF Siliciano</name></author><author><name sortKey="Maldarelli, F" uniqKey="Maldarelli F">F Maldarelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcmahon, D" uniqKey="Mcmahon D">D McMahon</name></author><author><name sortKey="Jones, J" uniqKey="Jones J">J Jones</name></author><author><name sortKey="Wiegand, A" uniqKey="Wiegand A">A Wiegand</name></author><author><name sortKey="Gange, Sj" uniqKey="Gange S">SJ Gange</name></author><author><name sortKey="Kearney, M" uniqKey="Kearney M">M Kearney</name></author><author><name sortKey="Palmer, S" uniqKey="Palmer S">S Palmer</name></author><author><name sortKey="Mcnulty, S" uniqKey="Mcnulty S">S McNulty</name></author><author><name sortKey="Metcalf, Ja" uniqKey="Metcalf J">JA Metcalf</name></author><author><name sortKey="Acosta, E" uniqKey="Acosta E">E Acosta</name></author><author><name sortKey="Rehm, C" uniqKey="Rehm C">C Rehm</name></author><author><name sortKey="Coffin, Jm" uniqKey="Coffin J">JM Coffin</name></author><author><name sortKey="Mellors, Jw" uniqKey="Mellors J">JW Mellors</name></author><author><name sortKey="Maldarelli, F" uniqKey="Maldarelli F">F Maldarelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buzon, Jm" uniqKey="Buzon J">JM Buzon</name></author><author><name sortKey="Massanella, M" uniqKey="Massanella M">M Massanella</name></author><author><name sortKey="Llibre, Jm" uniqKey="Llibre J">JM Llibre</name></author><author><name sortKey="Esteve, A" uniqKey="Esteve A">A Esteve</name></author><author><name sortKey="Dahl, V" uniqKey="Dahl V">V Dahl</name></author><author><name sortKey="Puertas, Mc" uniqKey="Puertas M">MC Puertas</name></author><author><name sortKey="Gatell, Jm" uniqKey="Gatell J">JM Gatell</name></author><author><name sortKey="Domingo, P" uniqKey="Domingo P">P Domingo</name></author><author><name sortKey="Paredes, R" uniqKey="Paredes R">R Paredes</name></author><author><name sortKey="Sharkey, M" uniqKey="Sharkey M">M Sharkey</name></author><author><name sortKey="Palmer, S" uniqKey="Palmer S">S Palmer</name></author><author><name sortKey="Stevenson, M" uniqKey="Stevenson M">M Stevenson</name></author><author><name sortKey="Clotet, B" uniqKey="Clotet B">B Clotet</name></author><author><name sortKey="Blanco, J" uniqKey="Blanco J">J Blanco</name></author><author><name sortKey="Martinez Picado, J" uniqKey="Martinez Picado J">J Martinez-Picado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yukl, Sa" uniqKey="Yukl S">SA Yukl</name></author><author><name sortKey="Shergill, Ak" uniqKey="Shergill A">AK Shergill</name></author><author><name sortKey="Mcquaid, K" uniqKey="Mcquaid K">K McQuaid</name></author><author><name sortKey="Gianella, S" uniqKey="Gianella S">S Gianella</name></author><author><name sortKey="Lampiris, H" uniqKey="Lampiris H">H Lampiris</name></author><author><name sortKey="Hare, Cb" uniqKey="Hare C">CB Hare</name></author><author><name sortKey="Pandori, M" uniqKey="Pandori M">M Pandori</name></author><author><name sortKey="Sinclair, E" uniqKey="Sinclair E">E Sinclair</name></author><author><name sortKey="Gunthard, Hf" uniqKey="Gunthard H">HF Gunthard</name></author><author><name sortKey="Fischer, M" uniqKey="Fischer M">M Fischer</name></author><author><name sortKey="Wong, Jk" uniqKey="Wong J">JK Wong</name></author><author><name sortKey="Havlir, Dv" uniqKey="Havlir D">DV Havlir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yilmaz, A" uniqKey="Yilmaz A">A Yilmaz</name></author><author><name sortKey="Verhofstede, C" uniqKey="Verhofstede C">C Verhofstede</name></author><author><name sortKey="D Avolio, A" uniqKey="D Avolio A">A D'Avolio</name></author><author><name sortKey="Watson, V" uniqKey="Watson V">V Watson</name></author><author><name sortKey="Hagberg, L" uniqKey="Hagberg L">L Hagberg</name></author><author><name sortKey="Fuchs, D" uniqKey="Fuchs D">D Fuchs</name></author><author><name sortKey="Svennerholm, B" uniqKey="Svennerholm B">B Svennerholm</name></author><author><name sortKey="Gisslen, M" uniqKey="Gisslen M">M Gisslen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chun, Tw" uniqKey="Chun T">TW Chun</name></author><author><name sortKey="Justement, Js" uniqKey="Justement J">JS Justement</name></author><author><name sortKey="Moir, S" uniqKey="Moir S">S Moir</name></author><author><name sortKey="Hallahan, Cw" uniqKey="Hallahan C">CW Hallahan</name></author><author><name sortKey="Maenza, J" uniqKey="Maenza J">J Maenza</name></author><author><name sortKey="Mullins, Ji" uniqKey="Mullins J">JI Mullins</name></author><author><name sortKey="Collier, Ac" uniqKey="Collier A">AC Collier</name></author><author><name sortKey="Corey, L" uniqKey="Corey L">L Corey</name></author><author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hocqueloux, L" uniqKey="Hocqueloux L">L Hocqueloux</name></author><author><name sortKey="Prazuck, T" uniqKey="Prazuck T">T Prazuck</name></author><author><name sortKey="Avettand Fenoel, V" uniqKey="Avettand Fenoel V">V Avettand-Fenoel</name></author><author><name sortKey="Lafeuillade, A" uniqKey="Lafeuillade A">A Lafeuillade</name></author><author><name sortKey="Cardon, B" uniqKey="Cardon B">B Cardon</name></author><author><name sortKey="Viard, Jp" uniqKey="Viard J">JP Viard</name></author><author><name sortKey="Rouzioux, C" uniqKey="Rouzioux C">C Rouzioux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bloch, Mt" uniqKey="Bloch M">MT Bloch</name></author><author><name sortKey="Smith, De" uniqKey="Smith D">DE Smith</name></author><author><name sortKey="Quan, D" uniqKey="Quan D">D Quan</name></author><author><name sortKey="Kaldor, Jm" uniqKey="Kaldor J">JM Kaldor</name></author><author><name sortKey="Zaunders, Jj" uniqKey="Zaunders J">JJ Zaunders</name></author><author><name sortKey="Petoumenos, K" uniqKey="Petoumenos K">K Petoumenos</name></author><author><name sortKey="Irvine, K" uniqKey="Irvine K">K Irvine</name></author><author><name sortKey="Law, M" uniqKey="Law M">M Law</name></author><author><name sortKey="Grey, P" uniqKey="Grey P">P Grey</name></author><author><name sortKey="Finlayson, Rj" uniqKey="Finlayson R">RJ Finlayson</name></author><author><name sortKey="Mcfarlane, R" uniqKey="Mcfarlane R">R McFarlane</name></author><author><name sortKey="Kelleher, Ad" uniqKey="Kelleher A">AD Kelleher</name></author><author><name sortKey="Carr, A" uniqKey="Carr A">A Carr</name></author><author><name sortKey="Cooper, Da" uniqKey="Cooper D">DA Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Markowitz, M" uniqKey="Markowitz M">M Markowitz</name></author><author><name sortKey="Jin, X" uniqKey="Jin X">X Jin</name></author><author><name sortKey="Hurley, A" uniqKey="Hurley A">A Hurley</name></author><author><name sortKey="Simon, V" uniqKey="Simon V">V Simon</name></author><author><name sortKey="Ramratnam, B" uniqKey="Ramratnam B">B Ramratnam</name></author><author><name sortKey="Louie, M" uniqKey="Louie M">M Louie</name></author><author><name sortKey="Deschenes, Gr" uniqKey="Deschenes G">GR Deschenes</name></author><author><name sortKey="Ramanathan, M" uniqKey="Ramanathan M">M Ramanathan</name></author><author><name sortKey="Barsoum, S" uniqKey="Barsoum S">S Barsoum</name></author><author><name sortKey="Vanderhoeven, J" uniqKey="Vanderhoeven J">J Vanderhoeven</name></author><author><name sortKey="He, T" uniqKey="He T">T He</name></author><author><name sortKey="Chung, C" uniqKey="Chung C">C Chung</name></author><author><name sortKey="Murray, J" uniqKey="Murray J">J Murray</name></author><author><name sortKey="Perelson, As" uniqKey="Perelson A">AS Perelson</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Ho, Dd" uniqKey="Ho D">DD Ho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Fx" uniqKey="Wang F">FX Wang</name></author><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name></author><author><name sortKey="Sullivan, J" uniqKey="Sullivan J">J Sullivan</name></author><author><name sortKey="Souder, E" uniqKey="Souder E">E Souder</name></author><author><name sortKey="Argyris, Eg" uniqKey="Argyris E">EG Argyris</name></author><author><name sortKey="Acheampong, Ea" uniqKey="Acheampong E">EA Acheampong</name></author><author><name sortKey="Fisher, J" uniqKey="Fisher J">J Fisher</name></author><author><name sortKey="Sierra, M" uniqKey="Sierra M">M Sierra</name></author><author><name sortKey="Thomson, Mm" uniqKey="Thomson M">MM Thomson</name></author><author><name sortKey="Najera, R" uniqKey="Najera R">R Najera</name></author><author><name sortKey="Frank, I" uniqKey="Frank I">I Frank</name></author><author><name sortKey="Kulkosky, J" uniqKey="Kulkosky J">J Kulkosky</name></author><author><name sortKey="Pomerantz, Rj" uniqKey="Pomerantz R">RJ Pomerantz</name></author><author><name sortKey="Nunnari, G" uniqKey="Nunnari G">G Nunnari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levy, Y" uniqKey="Levy Y">Y Levy</name></author><author><name sortKey="Lacabaratz, C" uniqKey="Lacabaratz C">C Lacabaratz</name></author><author><name sortKey="Weiss, L" uniqKey="Weiss L">L Weiss</name></author><author><name sortKey="Viard, Jp" uniqKey="Viard J">JP Viard</name></author><author><name sortKey="Goujard, C" uniqKey="Goujard C">C Goujard</name></author><author><name sortKey="Lelievre, Jd" uniqKey="Lelievre J">JD Lelievre</name></author><author><name sortKey="Boue, F" uniqKey="Boue F">F Boue</name></author><author><name sortKey="Molina, Jm" uniqKey="Molina J">JM Molina</name></author><author><name sortKey="Rouzioux, C" uniqKey="Rouzioux C">C Rouzioux</name></author><author><name sortKey="Avettand Fenoel, V" uniqKey="Avettand Fenoel V">V Avettand-Fenoel</name></author><author><name sortKey="Croughs, T" uniqKey="Croughs T">T Croughs</name></author><author><name sortKey="Beq, S" uniqKey="Beq S">S Beq</name></author><author><name sortKey="Thiebaut, R" uniqKey="Thiebaut R">R Thiebaut</name></author><author><name sortKey="Chene, G" uniqKey="Chene G">G Chene</name></author><author><name sortKey="Morre, M" uniqKey="Morre M">M Morre</name></author><author><name sortKey="Delfraissy, Jf" uniqKey="Delfraissy J">JF Delfraissy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sereti, I" uniqKey="Sereti I">I Sereti</name></author><author><name sortKey="Dunham, Rm" uniqKey="Dunham R">RM Dunham</name></author><author><name sortKey="Spritzler, J" uniqKey="Spritzler J">J Spritzler</name></author><author><name sortKey="Aga, E" uniqKey="Aga E">E Aga</name></author><author><name sortKey="Proschan, Ma" uniqKey="Proschan M">MA Proschan</name></author><author><name sortKey="Medvik, K" uniqKey="Medvik K">K Medvik</name></author><author><name sortKey="Battaglia, Ca" uniqKey="Battaglia C">CA Battaglia</name></author><author><name sortKey="Landay, Al" uniqKey="Landay A">AL Landay</name></author><author><name sortKey="Pahwa, S" uniqKey="Pahwa S">S Pahwa</name></author><author><name sortKey="Fischl, Ma" uniqKey="Fischl M">MA Fischl</name></author><author><name sortKey="Asmuth, Dm" uniqKey="Asmuth D">DM Asmuth</name></author><author><name sortKey="Tenorio, Ar" uniqKey="Tenorio A">AR Tenorio</name></author><author><name sortKey="Altman, Jd" uniqKey="Altman J">JD Altman</name></author><author><name sortKey="Fox, L" uniqKey="Fox L">L Fox</name></author><author><name sortKey="Moir, S" uniqKey="Moir S">S Moir</name></author><author><name sortKey="Malaspina, A" uniqKey="Malaspina A">A Malaspina</name></author><author><name sortKey="Morre, M" uniqKey="Morre M">M Morre</name></author><author><name sortKey="Buffet, R" uniqKey="Buffet R">R Buffet</name></author><author><name sortKey="Silvestri, G" uniqKey="Silvestri G">G Silvestri</name></author><author><name sortKey="Lederman, Mm" uniqKey="Lederman M">MM Lederman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reuse, S" uniqKey="Reuse S">S Reuse</name></author><author><name sortKey="Calao, M" uniqKey="Calao M">M Calao</name></author><author><name sortKey="Kabeya, K" uniqKey="Kabeya K">K Kabeya</name></author><author><name sortKey="Guiguen, A" uniqKey="Guiguen A">A Guiguen</name></author><author><name sortKey="Gatot, Js" uniqKey="Gatot J">JS Gatot</name></author><author><name sortKey="Quivy, V" uniqKey="Quivy V">V Quivy</name></author><author><name sortKey="Vanhulle, C" uniqKey="Vanhulle C">C Vanhulle</name></author><author><name sortKey="Lamine, A" uniqKey="Lamine A">A Lamine</name></author><author><name sortKey="Vaira, D" uniqKey="Vaira D">D Vaira</name></author><author><name sortKey="Demonte, D" uniqKey="Demonte D">D Demonte</name></author><author><name sortKey="Martinelli, V" uniqKey="Martinelli V">V Martinelli</name></author><author><name sortKey="Veithen, E" uniqKey="Veithen E">E Veithen</name></author><author><name sortKey="Cherrier, T" uniqKey="Cherrier T">T Cherrier</name></author><author><name sortKey="Avettand, V" uniqKey="Avettand V">V Avettand</name></author><author><name sortKey="Poutrel, S" uniqKey="Poutrel S">S Poutrel</name></author><author><name sortKey="Piette, J" uniqKey="Piette J">J Piette</name></author><author><name sortKey="De Launoit, Y" uniqKey="De Launoit Y">Y de Launoit</name></author><author><name sortKey="Moutschen, M" uniqKey="Moutschen M">M Moutschen</name></author><author><name sortKey="Burny, A" uniqKey="Burny A">A Burny</name></author><author><name sortKey="Rouzioux, C" uniqKey="Rouzioux C">C Rouzioux</name></author><author><name sortKey="De Wit, S" uniqKey="De Wit S">S De Wit</name></author><author><name sortKey="Herbein, G" uniqKey="Herbein G">G Herbein</name></author><author><name sortKey="Rohr, O" uniqKey="Rohr O">O Rohr</name></author><author><name sortKey="Collette, Y" uniqKey="Collette Y">Y Collette</name></author><author><name sortKey="Lambotte, O" uniqKey="Lambotte O">O Lambotte</name></author><author><name sortKey="Clumeck, N" uniqKey="Clumeck N">N Clumeck</name></author><author><name sortKey="Van Lint, C" uniqKey="Van Lint C">C Van Lint</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bolden, J" uniqKey="Bolden J">J Bolden</name></author><author><name sortKey="Peart, M" uniqKey="Peart M">M Peart</name></author><author><name sortKey="Johnstone, R" uniqKey="Johnstone R">R Johnstone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prince, Hm" uniqKey="Prince H">HM Prince</name></author><author><name sortKey="Bishton, Mj" uniqKey="Bishton M">MJ Bishton</name></author><author><name sortKey="Harrison, Sj" uniqKey="Harrison S">SJ Harrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lehrman, G" uniqKey="Lehrman G">G Lehrman</name></author><author><name sortKey="Hogue, Ib" uniqKey="Hogue I">IB Hogue</name></author><author><name sortKey="Palmer, S" uniqKey="Palmer S">S Palmer</name></author><author><name sortKey="Jennings, C" uniqKey="Jennings C">C Jennings</name></author><author><name sortKey="Spina, Ca" uniqKey="Spina C">CA Spina</name></author><author><name sortKey="Wiegand, A" uniqKey="Wiegand A">A Wiegand</name></author><author><name sortKey="Landay, Al" uniqKey="Landay A">AL Landay</name></author><author><name sortKey="Coombs, Rw" uniqKey="Coombs R">RW Coombs</name></author><author><name sortKey="Richman, Dd" uniqKey="Richman D">DD Richman</name></author><author><name sortKey="Mellors, Jw" uniqKey="Mellors J">JW Mellors</name></author><author><name sortKey="Coffin, Jm" uniqKey="Coffin J">JM Coffin</name></author><author><name sortKey="Bosch, Rj" uniqKey="Bosch R">RJ Bosch</name></author><author><name sortKey="Margolis, Dm" uniqKey="Margolis D">DM Margolis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Archin, Nm" uniqKey="Archin N">NM Archin</name></author><author><name sortKey="Eron, Jj" uniqKey="Eron J">JJ Eron</name></author><author><name sortKey="Palmer, S" uniqKey="Palmer S">S Palmer</name></author><author><name sortKey="Hartmann Duff, A" uniqKey="Hartmann Duff A">A Hartmann-Duff</name></author><author><name sortKey="Martinson, Ja" uniqKey="Martinson J">JA Martinson</name></author><author><name sortKey="Wiegand, A" uniqKey="Wiegand A">A Wiegand</name></author><author><name sortKey="Bandarenko, N" uniqKey="Bandarenko N">N Bandarenko</name></author><author><name sortKey="Schmitz, Jl" uniqKey="Schmitz J">JL Schmitz</name></author><author><name sortKey="Bosch, Rj" uniqKey="Bosch R">RJ Bosch</name></author><author><name sortKey="Landay, Al" uniqKey="Landay A">AL Landay</name></author><author><name sortKey="Coffin, Jm" uniqKey="Coffin J">JM Coffin</name></author><author><name sortKey="Margolis, Dm" uniqKey="Margolis D">DM Margolis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siliciano, Jd" uniqKey="Siliciano J">JD Siliciano</name></author><author><name sortKey="Lai, J" uniqKey="Lai J">J Lai</name></author><author><name sortKey="Callender, M" uniqKey="Callender M">M Callender</name></author><author><name sortKey="Pitt, E" uniqKey="Pitt E">E Pitt</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Margolick, Jb" uniqKey="Margolick J">JB Margolick</name></author><author><name sortKey="Gallant, Je" uniqKey="Gallant J">JE Gallant</name></author><author><name sortKey="Cofrancesco, J" uniqKey="Cofrancesco J">J Cofrancesco</name></author><author><name sortKey="Moore, Rd" uniqKey="Moore R">RD Moore</name></author><author><name sortKey="Gange, Sj" uniqKey="Gange S">SJ Gange</name></author><author><name sortKey="Siliciano, Rf" uniqKey="Siliciano R">RF Siliciano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sagot Lerolle, N" uniqKey="Sagot Lerolle N">N Sagot-Lerolle</name></author><author><name sortKey="Lamine, A" uniqKey="Lamine A">A Lamine</name></author><author><name sortKey="Chaix, Ml" uniqKey="Chaix M">ML Chaix</name></author><author><name sortKey="Boufassa, F" uniqKey="Boufassa F">F Boufassa</name></author><author><name sortKey="Aboulker, Jp" uniqKey="Aboulker J">JP Aboulker</name></author><author><name sortKey="Costagliola, D" uniqKey="Costagliola D">D Costagliola</name></author><author><name sortKey="Goujard, C" uniqKey="Goujard C">C Goujard</name></author><author><name sortKey="Pallier, C" uniqKey="Pallier C">C Pallier</name></author><author><name sortKey="Delfraissy, Jf" uniqKey="Delfraissy J">JF Delfraissy</name></author><author><name sortKey="Lambotte, O" uniqKey="Lambotte O">O Lambotte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Contreras, X" uniqKey="Contreras X">X Contreras</name></author><author><name sortKey="Schweneker, M" uniqKey="Schweneker M">M Schweneker</name></author><author><name sortKey="Chen, Cs" uniqKey="Chen C">CS Chen</name></author><author><name sortKey="Mccune, Jm" uniqKey="Mccune J">JM McCune</name></author><author><name sortKey="Deeks, Sg" uniqKey="Deeks S">SG Deeks</name></author><author><name sortKey="Martin, J" uniqKey="Martin J">J Martin</name></author><author><name sortKey="Peterlin, Bm" uniqKey="Peterlin B">BM Peterlin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Archin, Nm" uniqKey="Archin N">NM Archin</name></author><author><name sortKey="Espeseth, A" uniqKey="Espeseth A">A Espeseth</name></author><author><name sortKey="Parker, D" uniqKey="Parker D">D Parker</name></author><author><name sortKey="Cheema, M" uniqKey="Cheema M">M Cheema</name></author><author><name sortKey="Hazuda, D" uniqKey="Hazuda D">D Hazuda</name></author><author><name sortKey="Margolis, Dm" uniqKey="Margolis D">DM Margolis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burnett, Jc" uniqKey="Burnett J">JC Burnett</name></author><author><name sortKey="Lim, Ki" uniqKey="Lim K">KI Lim</name></author><author><name sortKey="Calafi, A" uniqKey="Calafi A">A Calafi</name></author><author><name sortKey="Rossi, Jj" uniqKey="Rossi J">JJ Rossi</name></author><author><name sortKey="Schaffer, Dv" uniqKey="Schaffer D">DV Schaffer</name></author><author><name sortKey="Arkin, Ap" uniqKey="Arkin A">AP Arkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holt, N" uniqKey="Holt N">N Holt</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Kim, K" uniqKey="Kim K">K Kim</name></author><author><name sortKey="Friedman, G" uniqKey="Friedman G">G Friedman</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Taupin, V" uniqKey="Taupin V">V Taupin</name></author><author><name sortKey="Crooks, Gm" uniqKey="Crooks G">GM Crooks</name></author><author><name sortKey="Kohn, Db" uniqKey="Kohn D">DB Kohn</name></author><author><name sortKey="Gregory, Pd" uniqKey="Gregory P">PD Gregory</name></author><author><name sortKey="Holmes, Mc" uniqKey="Holmes M">MC Holmes</name></author><author><name sortKey="Cannon, Pm" uniqKey="Cannon P">PM Cannon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Digiusto, Dl" uniqKey="Digiusto D">DL DiGiusto</name></author><author><name sortKey="Krishnan, A" uniqKey="Krishnan A">A Krishnan</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Li, S" uniqKey="Li S">S Li</name></author><author><name sortKey="Rao, A" uniqKey="Rao A">A Rao</name></author><author><name sortKey="Mi, S" uniqKey="Mi S">S Mi</name></author><author><name sortKey="Yam, P" uniqKey="Yam P">P Yam</name></author><author><name sortKey="Stinson, S" uniqKey="Stinson S">S Stinson</name></author><author><name sortKey="Kalos, M" uniqKey="Kalos M">M Kalos</name></author><author><name sortKey="Alvarnas, J" uniqKey="Alvarnas J">J Alvarnas</name></author><author><name sortKey="Lacey, Sf" uniqKey="Lacey S">SF Lacey</name></author><author><name sortKey="Yee, Jk" uniqKey="Yee J">JK Yee</name></author><author><name sortKey="Li, M" uniqKey="Li M">M Li</name></author><author><name sortKey="Couture, L" uniqKey="Couture L">L Couture</name></author><author><name sortKey="Hsu, D" uniqKey="Hsu D">D Hsu</name></author><author><name sortKey="Forman, Sj" uniqKey="Forman S">SJ Forman</name></author><author><name sortKey="Rossi, Jj" uniqKey="Rossi J">JJ Rossi</name></author><author><name sortKey="Zaia, Ja" uniqKey="Zaia J">JA Zaia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Sadr, Wm" uniqKey="El Sadr W">WM El-Sadr</name></author><author><name sortKey="Lundgren, Jd" uniqKey="Lundgren J">JD Lundgren</name></author><author><name sortKey="Neaton, Jd" uniqKey="Neaton J">JD Neaton</name></author><author><name sortKey="Gordin, F" uniqKey="Gordin F">F Gordin</name></author><author><name sortKey="Abrams, D" uniqKey="Abrams D">D Abrams</name></author><author><name sortKey="Arduino, Rc" uniqKey="Arduino R">RC Arduino</name></author><author><name sortKey="Babiker, A" uniqKey="Babiker A">A Babiker</name></author><author><name sortKey="Burman, W" uniqKey="Burman W">W Burman</name></author><author><name sortKey="Clumeck, N" uniqKey="Clumeck N">N Clumeck</name></author><author><name sortKey="Cohen, Cj" uniqKey="Cohen C">CJ Cohen</name></author><author><name sortKey="Cohn, D" uniqKey="Cohn D">D Cohn</name></author><author><name sortKey="Cooper, D" uniqKey="Cooper D">D Cooper</name></author><author><name sortKey="Darbyshire, J" uniqKey="Darbyshire J">J Darbyshire</name></author><author><name sortKey="Emery, S" uniqKey="Emery S">S Emery</name></author><author><name sortKey="Fatkenheuer, G" uniqKey="Fatkenheuer G">G Fatkenheuer</name></author><author><name sortKey="Gazzard, B" uniqKey="Gazzard B">B Gazzard</name></author><author><name sortKey="Grund, B" uniqKey="Grund B">B Grund</name></author><author><name sortKey="Hoy, J" uniqKey="Hoy J">J Hoy</name></author><author><name sortKey="Klingman, K" uniqKey="Klingman K">K Klingman</name></author><author><name sortKey="Losso, M" uniqKey="Losso M">M Losso</name></author><author><name sortKey="Markowitz, N" uniqKey="Markowitz N">N Markowitz</name></author><author><name sortKey="Neuhaus, J" uniqKey="Neuhaus J">J Neuhaus</name></author><author><name sortKey="Phillips, A" uniqKey="Phillips A">A Phillips</name></author><author><name sortKey="Rappoport, C" uniqKey="Rappoport C">C Rappoport</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article" xml:lang="en"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Int AIDS Soc</journal-id><journal-id journal-id-type="iso-abbrev">J Int AIDS Soc</journal-id><journal-title-group><journal-title>Journal of the International AIDS Society</journal-title></journal-title-group><issn pub-type="epub">1758-2652</issn><publisher><publisher-name>The International AIDS Society</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21255462</article-id><article-id pub-id-type="pmc">3037295</article-id><article-id pub-id-type="publisher-id">1758-2652-14-4</article-id><article-id pub-id-type="doi">10.1186/1758-2652-14-4</article-id><article-categories><subj-group subj-group-type="heading"><subject>Commentary</subject></subj-group></article-categories><title-group><article-title>Finding a cure for HIV: will it ever be achievable?</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Lewin</surname><given-names>Sharon R</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref><xref ref-type="aff" rid="I3">3</xref><email>s.lewin@alfred.org.au</email></contrib><contrib contrib-type="author" id="A2"><name><surname>Evans</surname><given-names>Vanessa A</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>Vanessa.Evans@monash.edu</email></contrib><contrib contrib-type="author" id="A3"><name><surname>Elliott</surname><given-names>Julian H</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref><xref ref-type="aff" rid="I3">3</xref><email>julian.elliott@alfred.org.au</email></contrib><contrib contrib-type="author" id="A4"><name><surname>Spire</surname><given-names>Bruno</given-names></name><xref ref-type="aff" rid="I4">4</xref><xref ref-type="aff" rid="I5">5</xref><xref ref-type="aff" rid="I6">6</xref><email>bruno.spire@inserm.fr</email></contrib><contrib contrib-type="author" id="A5"><name><surname>Chomont</surname><given-names>Nicolas</given-names></name><xref ref-type="aff" rid="I7">7</xref><email>nchomont@vgti-fl.org</email></contrib></contrib-group><aff id="I1"><label>1</label>Department of Medicine, Monash University, (99 Commercial Rd), Melbourne, (3004), Australia</aff><aff id="I2"><label>2</label>Infectious Diseases Unit, Alfred Hospital, (85 Commercial Rd), Melbourne, (3004), Australia</aff><aff id="I3"><label>3</label>Centre of Virology, Burnet Institute, (85 Commercial Rd), Melbourne, (3004), Australia</aff><aff id="I4"><label>4</label>SE4S, INSERM UMR 912, (23 rue Stanislas Torrents), Marseille, (13006), France</aff><aff id="I5"><label>5</label>SE4S, Université de la Méditerranée, IRD, (23 rue Stanislas Torrents), Marseille, (13006), France</aff><aff id="I6"><label>6</label>AIDES, (14 rue Scandicci, Pantin (93508), France</aff><aff id="I7"><label>7</label>Vaccine and Gene Therapy Institute, (11350 SW Village Parkway), Port St Lucie, (34987), FL, USA</aff><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>24</day><month>1</month><year>2011</year></pub-date><volume>14</volume><fpage>4</fpage><lpage>4</lpage><history><date date-type="received"><day>12</day><month>10</month><year>2010</year></date><date date-type="accepted"><day>24</day><month>1</month><year>2011</year></date></history><permissions><copyright-statement>Copyright ©2011 Lewin et al; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2011</copyright-year><copyright-holder>Lewin et al; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://www.jiasociety.org/content/14/1/4"></self-uri><abstract><p>Combination antiretroviral therapy (cART) has led to a major reduction in HIV-related mortality and morbidity. However, HIV still cannot be cured. With the absence of an effective prophylactic or therapeutic vaccine, increasing numbers of infected people, emerging new toxicities secondary to cART and the need for life-long treatment, there is now a real urgency to find a cure for HIV.</p><p>There are currently multiple barriers to curing HIV. The most significant barrier is the establishment of a latent or "silent" infection in resting CD4+ T cells. In latent HIV infection, the virus is able to integrate into the host cell genome, but does not proceed to active replication. As a consequence, antiviral agents, as well as the immune system, are unable to eliminate these long-lived, latently infected cells. Reactivation of latently infected resting CD4+ T cells can then re-establish infection once cART is stopped. Other significant barriers to cure include residual viral replication in patients receiving cART, even when the virus is not detectable by conventional assays. In addition, HIV can be sequestered in anatomical reservoirs, such as the brain, gastrointestinal tract and genitourinary tract.</p><p>Achieving either a functional cure (long-term control of HIV in the absence of cART) or a sterilizing cure (elimination of all HIV-infected cells) remains a major challenge. Several studies have now demonstrated that treatment intensification appears to have little impact on latent reservoirs. Some potential and promising approaches that may reduce the latent reservoir include very early initiation of cART and the use of agents that could potentially reverse latent infection.</p><p>Agents that reverse latent infection will promote viral production; however, simultaneous administration of cART will prevent subsequent rounds of viral replication. Such drugs as histone deacetylase inhibitors, currently used and licensed for the treatment of some cancers, or activating latently infected resting cells with cytokines, such as IL-7 or prostratin, show promising results in reversing latency <italic>in vitro </italic>when used either alone or in combination. In order to move forward toward clinical trials that target eradication, there needs to be careful consideration of the risks and benefits of these approaches, agreement on the most informative endpoints for eradication studies and greater engagement of the infected community.</p></abstract></article-meta></front><body><sec><title>Introduction</title><p>The XI International AIDS Conference in Vancouver in 1996 marked the beginning of the great success story of combination antiretroviral therapy (cART). Over the past 15 years, mortality and morbidity from HIV has fallen dramatically in both resource-poor and resource-rich countries [<xref ref-type="bibr" rid="B1">1</xref>-<xref ref-type="bibr" rid="B3">3</xref>]. Treatment has become simpler and less toxic, and more than 5 million people in low- and middle-income countries are now receiving cART [<xref ref-type="bibr" rid="B4">4</xref>]. Despite these major successes, and in the absence of an effective vaccine, the need to find a cure for HIV is even more urgent now, in 2010, than ever before.</p></sec><sec sec-type="discussion"><title>Discussion</title><sec><title>Why do we need a cure for HIV?</title><p>Even with the major successes of cART, full life expectancy for patients living with HIV has not been restored. In a prospective study of 3990 HIV-infected individuals and 379,872 HIV-uninfected controls in Denmark, the probability of survival was examined in the period prior to cART (1995-1996), during early cART (1997-1999) and during late cART (2000-2005) [<xref ref-type="bibr" rid="B5">5</xref>]. There was a clear and substantial increase in survival following the introduction of cART in the late 1990s. However, even in the late cART period, life expectancy remained significantly less than population controls. In fact, the chance of a person with HIV reaching the age of 70 was 50% that of uninfected population controls. These findings are consistent with observations from other large cohort studies [<xref ref-type="bibr" rid="B6">6</xref>].</p><p>The incidence of significant morbidity remains elevated despite successful cART due to complex interactions between drug toxicity [<xref ref-type="bibr" rid="B7">7</xref>], persistent inflammation [<xref ref-type="bibr" rid="B8">8</xref>] and risk behaviours [<xref ref-type="bibr" rid="B9">9</xref>]. Multiple studies have demonstrated that people living with HIV are at increased risk of cardiovascular disease, metabolic disorders, neurocognitive abnormalities, liver and renal disease, bone disorders, malignancy and frailty (reviewed in [<xref ref-type="bibr" rid="B10">10</xref>]). As a consequence, managing the complex care needs of HIV-infected individuals remains a major challenge.</p><p>Finally, despite the clear need for universal access to cART and the ongoing expansion in health systems, there remains a lack of financial resources to support life-long treatment, for everyone in need of treatment. Reaching all those in need of treatment is getting harder as donor contributions stabilize and treatment recommendations shift towards earlier initiation of cART [<xref ref-type="bibr" rid="B11">11</xref>,<xref ref-type="bibr" rid="B12">12</xref>], which will increase the population of people judged to be in need of treatment. Furthermore, new HIV infections continue to outpace the number of people starting treatment. Even during the rapid scale up of access to cART in recent years, for every two people starting cART, there were five new infections [<xref ref-type="bibr" rid="B13">13</xref>]. This imbalance is unlikely to be reversed in the near future despite evidence that global HIV incidence is now declining [<xref ref-type="bibr" rid="B14">14</xref>] and the promise of more effective biomedical interventions, including circumcision and tenofovir-containing microbicides [<xref ref-type="bibr" rid="B15">15</xref>,<xref ref-type="bibr" rid="B16">16</xref>].</p><p>Recent work, commissioned by the Clinton Foundation as part of the AIDS 2031 Project, has modelled the total projected annual AIDS resource requirements for low-and middle-income countries if cART scale up continues at current rates [<xref ref-type="bibr" rid="B17">17</xref>]. If HIV treatment is initiated at a CD4 count of 200 cells/mm<sup>3 </sup>and 40% cART coverage is achieved, the estimated costs by 2031 are predicted to approach $25 billion per year. If cART coverage instead reaches 80% by 2031, the annual cost of treatment is predicted to reach almost $35 billion [<xref ref-type="bibr" rid="B17">17</xref>]. Under this scenario, which is broadly consistent with the international community's commitment to universal access, the predicted cost of HIV treatment alone will account for almost half the US foreign aid budget by 2016 [<xref ref-type="bibr" rid="B13">13</xref>].</p></sec><sec><title>Current barriers to curing HIV</title><p>Following cART, HIV RNA in blood rapidly reduces to undetectable levels (<50 copies/ml). However, regardless of whether the patient has been on treatment for two years or 15 years, whether they have been on three drugs or six drugs, whether they started treatment within one year or 10 years of infection, as soon as treatment is stopped, the virus rapidly rebounds. The question then is: where is the virus sitting while the patient has a viral load of less than 50 copies/ml?</p><p>More than 10 years ago, several groups identified the persistence of virus in long-lived latently infected cells, measured as HIV DNA. They demonstrated that upon stimulation, these silent viral genomes can be reactivated and subsequently produce infectious viral particles [<xref ref-type="bibr" rid="B18">18</xref>-<xref ref-type="bibr" rid="B20">20</xref>]. More recently, using a highly sensitive assay that detects HIV RNA in plasma down to 1 copy/ml, several groups have shown persistent low-level viremia of around 3-5 copies/ml in 80% of patients [<xref ref-type="bibr" rid="B21">21</xref>,<xref ref-type="bibr" rid="B22">22</xref>]. In other words, there is no such thing as an undetectable viral load and the virus clearly persists. Currently, some of the major research questions are: what is contributing to this low-level viremia and persistent DNA, and will it ever be possible to eliminate this residual virus?</p><p>There are likely to be at least three major barriers to curing HIV. These include the persistence of long-lived, latently infected cells, residual viral replication and anatomical reservoirs. Latently infected cells are predominantly resting CD4+ T cells [<xref ref-type="bibr" rid="B18">18</xref>-<xref ref-type="bibr" rid="B20">20</xref>], but also include other long-lived cells, such as monocyte/macrophages [<xref ref-type="bibr" rid="B23">23</xref>] and astrocytes [<xref ref-type="bibr" rid="B24">24</xref>,<xref ref-type="bibr" rid="B25">25</xref>]. Latency represents the biggest challenge to finding a cure.</p><p><italic>In vivo</italic>, HIV latency occurs in resting CD4+ T cells either as pre-integration or post-integration latency. Pre-integration latency refers to unintegrated HIV DNA that is unstable and will either degrade or will integrate into the host cell genome, usually following cell activation [<xref ref-type="bibr" rid="B26">26</xref>]. Post-integration latency refers to the presence of integrated HIV DNA in cells that are not actively producing viral particles. The major reservoir of cells that harbour post-integration latency <italic>in vivo </italic>are resting memory CD4+ T cells [<xref ref-type="bibr" rid="B27">27</xref>,<xref ref-type="bibr" rid="B28">28</xref>]. Once integration occurs, the virus can persist in these cells for long periods of time, unaffected by antiretroviral drugs or host immune recognition [<xref ref-type="bibr" rid="B19">19</xref>,<xref ref-type="bibr" rid="B29">29</xref>]. Post-integration latency is therefore critical for the maintenance of the HIV latent reservoir.</p><p>In activated CD4+ T cells, the virus life cycle is efficient, with rapid integration, virion production and subsequent death of the infected cells. In contrast, infection of resting CD4+ T cells is difficult to establish <italic>in vitro </italic>due to multiple blocks in the viral life cycle [<xref ref-type="bibr" rid="B30">30</xref>,<xref ref-type="bibr" rid="B31">31</xref>]. However, resting CD4+ T cells are clearly infected <italic>in vivo </italic>[<xref ref-type="bibr" rid="B32">32</xref>,<xref ref-type="bibr" rid="B33">33</xref>], as well as <italic>ex vivo</italic>, in tissue blocks [<xref ref-type="bibr" rid="B34">34</xref>,<xref ref-type="bibr" rid="B35">35</xref>], and contain stable integrated forms of HIV.</p><p><italic>In vitro</italic>, our group has clearly demonstrated that latent infection can be established in CD4+ resting memory T cells, following incubation with multiple chemokines that bind to the chemokine receptors highly expressed on resting CD4+ T cells [<xref ref-type="bibr" rid="B36">36</xref>,<xref ref-type="bibr" rid="B37">37</xref>]. Studies such as this support the hypothesis that latency can result from direct infection of resting memory CD4+ T cells, possibly as a result of exposure to soluble factors found in lymphoid tissues. An alternative possibility for infection of resting CD4+ T cells is the reversion of an infected, activated cell to a resting state, which has also been demonstrated <italic>in vitro </italic>[<xref ref-type="bibr" rid="B38">38</xref>-<xref ref-type="bibr" rid="B40">40</xref>] (Figure <xref ref-type="fig" rid="F1">1</xref>).</p><fig id="F1" position="float"><label>Figure 1</label><caption><p><bold>HIV latency and infection of resting memory CD4+ T cells</bold>. <bold>(A) </bold>In activated CD4+ T cells the virus life cycle is efficient, with rapid integration, virion production and subsequent death of the infected cells. <bold>(B) </bold>Latent infection can be established in CD4+ resting memory T cells following incubation with multiple chemokines [<xref ref-type="bibr" rid="B36">36</xref>,<xref ref-type="bibr" rid="B37">37</xref>]. <bold>(C) </bold>Alternatively, latently infected cells may arise following the reversion of an infected activated cell to a resting state [<xref ref-type="bibr" rid="B38">38</xref>-<xref ref-type="bibr" rid="B40">40</xref>].</p></caption><graphic xlink:href="1758-2652-14-4-1"></graphic></fig><p>These latently infected CD4+ T cells are thought to be extremely long lived [<xref ref-type="bibr" rid="B41">41</xref>]; however, it is highly likely that this pool of cells is also maintained by homeostatic proliferation [<xref ref-type="bibr" rid="B27">27</xref>]. Latently infected cells can intermittently release virus following activation, making them a major barrier to cure. Latency was originally described in one particular subset of CD4+ T cells called central memory T cells. Because these cells can persist for decades, they ensure the maintenance of long-lasting cellular immunity, but also constitute an extremely stable cellular reservoir for the virus [<xref ref-type="bibr" rid="B18">18</xref>,<xref ref-type="bibr" rid="B19">19</xref>].</p><p>Over the past few years, several groups have identified that latency can exist in a range of CD4+ T cell subsets, including transitional memory T cells, naïve T cells, thymocytes and multipotent progenitor cells or stem cells [<xref ref-type="bibr" rid="B27">27</xref>,<xref ref-type="bibr" rid="B42">42</xref>-<xref ref-type="bibr" rid="B44">44</xref>]. Together, these cells constitute the latent reservoir. There is also some indirect evidence that the normal process of homeostatic proliferation maintains the number of latently infected naïve and transitional memory cells. Following mitotic cell division, both daughter cells contain integrated HIV DNA, meaning that this reservoir may be replenished or even increase in size on cART [<xref ref-type="bibr" rid="B27">27</xref>,<xref ref-type="bibr" rid="B44">44</xref>].</p><p>The alternative explanation for persistent virus is that there is ongoing virus replication in activated T cells. In other words, cART is effective, but not 100% effective. However, it is currently unclear how much residual replication contributes to HIV persistence. There are several pieces of evidence that argue against residual replication, including the very stable sequence of low-level viremia in plasma [<xref ref-type="bibr" rid="B45">45</xref>,<xref ref-type="bibr" rid="B46">46</xref>] and the absence of drug-resistant virus in either plasma or CD4+ T cells [<xref ref-type="bibr" rid="B47">47</xref>,<xref ref-type="bibr" rid="B48">48</xref>].</p><p>Finally, we know that HIV can hide in anatomical reservoirs, such as the brain [<xref ref-type="bibr" rid="B49">49</xref>], the gastrointestinal tract [<xref ref-type="bibr" rid="B50">50</xref>] and the genital tract [<xref ref-type="bibr" rid="B51">51</xref>]. In the gastrointestinal tract of patients receiving cART, persisting infected cells are almost 10 times more frequent than in blood [<xref ref-type="bibr" rid="B50">50</xref>,<xref ref-type="bibr" rid="B52">52</xref>]. In these anatomical sites, virus can persist in activated, replicating cells, as well as long-lived, latently infected cells, such as dendritic cells, macrophages and astrocytes. These sites may also have unique barriers to entry of cART, which limit the penetration of drugs.</p></sec><sec><title>What type of cure might ultimately be achievable?</title><p>There are two potential strategies for cure. The first is what we might consider an "infectious diseases model" of cure, where the pathogen is treated and it disappears all together. This would require the elimination of all HIV-infected cells and for patients to have an HIV RNA count of less than 1 copy/ml. This is now commonly referred to as a sterilizing cure. The alternative approach would be to aim for remission or what we might consider a "cancer model" of cure, where an individual would have long-term health in the absence of treatment, with perhaps low-level viremia at less than 50 copies/ml. This is commonly referred to as a functional cure (Table <xref ref-type="table" rid="T1">1</xref>).</p><table-wrap id="T1" position="float"><label>Table 1</label><caption><p>Overall potential strategies for curing HIV</p></caption><table frame="hsides" rules="groups"><tbody><tr><td align="left"><bold>Sterilizing cure</bold></td><td align="left"><bold>Functional cure</bold></td></tr><tr><td colspan="1"><hr></hr></td><td colspan="1"><hr></hr></td></tr><tr><td align="left">Infectious diseases model</td><td align="left">Cancer model</td></tr><tr><td align="left">Cure</td><td align="left">Remission</td></tr><tr><td align="left">Elimination of all HIV-infected cells</td><td align="left">Long-term health in the absence of cART</td></tr><tr><td align="left">HIV RNA <1 copy/ml</td><td align="left">HIV RNA <50 copies/ml</td></tr></tbody></table><table-wrap-foot><p>cART, combination antiretroviral therapy</p></table-wrap-foot></table-wrap><p>There are examples of both a sterilizing and functional cure that we need to learn from when designing new strategies for curing HIV. The recent case report of a German patient with acute myeloid leukemia, who received a bone marrow transplant from a donor who was resistant to HIV, is the only current example of a sterilizing cure [<xref ref-type="bibr" rid="B53">53</xref>]. The bone marrow donor carried a mutation in the CCR5 gene, a 32-base pair deletion, which knocks out expression of CCR5, the major coreceptor for HIV. Following transplantation, the patient stopped cART due to interactions with his chemotherapeutic drugs. Interestingly, virus did not rebound in the blood of this patient, and in more detailed studies, including multiple biopsies of his gastrointestinal tract, analysis of his cerebrospinal fluid (CSF) and lymph nodes, there were no detectable signs of HIV. The patient is now more than three years post transplant and HIV is still not detected. While a strategy of using bone marrow transplantation with a CCR5 mutant donor is not a realistic cure for HIV given the toxicity of the treatment, we need to comprehensively study this patient to fully understand how and why HIV was eliminated.</p><p>Elite controllers are another group that will teach us a lot about trying to achieve a functional cure. Elite controllers represent a unique group of patients who are able to achieve a consistent HIV RNA of less than 50 copies/ml in the absence of treatment [<xref ref-type="bibr" rid="B54">54</xref>]. There have been multiple studies examining the role of genetics, the virus and the immune response in elite controllers [<xref ref-type="bibr" rid="B55">55</xref>-<xref ref-type="bibr" rid="B57">57</xref>]. A consistent result from this work is the persistence of a robust HIV-specific T cell response in elite controllers, providing supportive evidence that inducing an effective immune response, perhaps via vaccination, may be a strategy to achieving a functional cure.</p><p>However, to date, the use of therapeutic vaccination in patients receiving cART has not been successful [<xref ref-type="bibr" rid="B58">58</xref>]. It is also important to note that approximately 7% of elite controllers experience a decline in their CD4+ T cells despite maintaining a viral load of less than 50 copies/ml. Ongoing virus replication and evolution, in addition to enhanced immune activation, has also been observed in these patients [<xref ref-type="bibr" rid="B55">55</xref>,<xref ref-type="bibr" rid="B59">59</xref>].</p></sec><sec><title>Future and current strategies for cure</title><sec><title>Treatment intensification</title><p>There have been a number of studies that have looked at the effect of treatment intensification on residual virus in patients receiving cART. These studies have included the addition of agents, such as Enfuvirtide, additional protease inhibitors or Raltegravir, to an already suppressive regimen [<xref ref-type="bibr" rid="B60">60</xref>-<xref ref-type="bibr" rid="B63">63</xref>]. Disappointingly, none of these studies have demonstrated any decline in low-level viremia or cell-associated HIV DNA. In addition, recently two small, non-randomized studies showed that treatment intensification had no significant effect on residual virus infection in the gastrointestinal tract (n = 7) [<xref ref-type="bibr" rid="B63">63</xref>] or in the cerebrospinal fluid (n = 10) [<xref ref-type="bibr" rid="B64">64</xref>]. Larger, randomized studies with longer follow up are still required to determine if treatment intensification may have any impact on persistent virus infection.</p><p>In one study, patients were randomized to Raltegravir intensification or to continue their current suppressive cART regimen. The addition of Raltegravir led to an increase in 2LTR circles within two weeks in one-third of patients, consistent with evidence of residual viral replication, although there was still no change in persistent low-level HIV RNA or cell-associated DNA, following intensification [<xref ref-type="bibr" rid="B62">62</xref>]. Therefore, although this study did not show an impact on the latent reservoir, the presence of active virus replication in some patients has significant implications for designing studies that may promote virus replication from latently infected cells.</p></sec><sec><title>Early treatment</title><p>Early treatment may be a potential strategy to reduce or even control the number of persistent latently infected cells. Several groups have demonstrated that the number of infected cells, as measured by cell-associated HIV DNA, decreases to a significantly lower level if treatment is initiated during acute rather than chronic infection [<xref ref-type="bibr" rid="B65">65</xref>,<xref ref-type="bibr" rid="B66">66</xref>]. Additionally, a recent longitudinal study demonstrated that in five of 32 (16%) patients who initiated treatment during acute infection, a viral load of less than 50 copies/ml was maintained after stopping cART (median of 77 months) [<xref ref-type="bibr" rid="B66">66</xref>].</p><p>However, this study was in contrast to many other reports of viral rebound in nearly all patients following cessation of cART, even when initiated during acute infection [<xref ref-type="bibr" rid="B67">67</xref>,<xref ref-type="bibr" rid="B68">68</xref>]. Why some but not all patients are able to control infection following treatment during acute infection is unclear. The role of very early treatment initiation in limiting seeding of the HIV reservoir, as well as preserving the immune responses capable of controlling HIV replication, requires further investigation.</p></sec><sec><title>Elimination of latently infected T cells</title><p>One strategy to eliminate latently infected cells is to convert these cells into activated cells. Activation of latently infected T cells would induce virus production and subsequent cell death, while further rounds of infection would be blocked by cART. IL-7 is a cytokine that can effectively do this in the laboratory [<xref ref-type="bibr" rid="B69">69</xref>]. IL-7 has also recently been shown to be safe and well tolerated in patients with HIV infection [<xref ref-type="bibr" rid="B70">70</xref>,<xref ref-type="bibr" rid="B71">71</xref>]. One concern, however, with IL-7 is that this cytokine may also induce the proliferation of latently infected cells without activating them [<xref ref-type="bibr" rid="B27">27</xref>]. IL-7 is currently undergoing clinical trials (ERAMUNE, <ext-link ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov">http://www.clinicaltrials.gov</ext-link>), as a strategy to reduce the size of the latent reservoir, and results of this trial are awaited with high interest.</p><p>There are alternative compounds, such as prostratin, that can promote T cell activation and HIV transcription <italic>in vitro </italic>[<xref ref-type="bibr" rid="B72">72</xref>]. However, prostratin has not yet been trialled in any human studies.</p><p>Alternatively, a more targeted approach would be to turn on the HIV genes within the latently infected cells. In a latently infected cell, the HIV genes are silent and turned off. Histone deacetylase inhibitors (HDACi) are drugs that can modify gene expression by changing the acetylation state of genes. These drugs are also able to turn HIV genes on in latently infected cells <italic>in vitro</italic>. In cancer cells, HDACi induce cell death of the malignant cells and many HDACi are now in advanced clinical development for the treatment of different cancers [<xref ref-type="bibr" rid="B73">73</xref>,<xref ref-type="bibr" rid="B74">74</xref>]. Although valproic acid, a relatively weak HDACi, showed promising effects in a small pilot study [<xref ref-type="bibr" rid="B75">75</xref>], further retrospective studies failed to demonstrate any benefit from this intervention [<xref ref-type="bibr" rid="B76">76</xref>-<xref ref-type="bibr" rid="B78">78</xref>].</p><p>A far more potent HDACi, Vorinostat (also called SAHA), is already licensed for the treatment of cutaneous T cell lymphoma, is well tolerated in humans, and has significant activity in promoting HIV or turning HIV genes on <italic>in vitro </italic>[<xref ref-type="bibr" rid="B79">79</xref>,<xref ref-type="bibr" rid="B80">80</xref>]. Other drugs, such as methylation inhibitors, have a similar effect in promoting HIV transcription in latently infected cells. The most potent effect observed in laboratory models, however, results when a combination of drugs is used [<xref ref-type="bibr" rid="B72">72</xref>,<xref ref-type="bibr" rid="B81">81</xref>]. It is therefore likely that the elimination of latently infected cells <italic>in vivo </italic>will require the addition of more than a single drug to a patient's cART regimen.</p><p>None of these strategies, however, specifically target HIV-infected cells, and latently infected cells are rare. On average, they occur one in a million, or one in a 100,000 cells [<xref ref-type="bibr" rid="B18">18</xref>]. Therefore, these current strategies could potentially have effects on uninfected cells leading to toxicities and, therefore, the risk benefit of these strategies needs to be carefully evaluated.</p></sec><sec><title>Making cells resistant to HIV</title><p>Future strategies aimed at making CD4+ T cells resistant to HIV are also currently being investigated, which would ultimately allow for the cessation of cART. Some approaches have included gene therapy to reduce expression of the chemokine receptor CCR5. This has been successfully performed in mice through the introduction of a zinc finger nuclease, which inhibits CCR5 expression, into the CD34+ hemapoietic progenitor cells. This led to a reduction in the expression of CCR5, and following HIV infection of these mice, CD4+ T cells did not decline [<xref ref-type="bibr" rid="B82">82</xref>].</p><p>An alternative approach is to use RNA-based gene therapy to reduce CCR5 expression, as well as specifically inhibit HIV replication [<xref ref-type="bibr" rid="B83">83</xref>]. This approach was recently tested in four HIV-infected patients with AIDS-associated lymphoma, who received a transplant with three RNA-based gene products as part of the transplant. The investigators demonstrated that this procedure was safe and that the transferred genes persisted in a subset of cells for 24 months. Although widespread use of these therapies is many years away, these results are encouraging for the possible development of a gene therapy-based treatment strategy that may achieve a functional cure.</p></sec></sec><sec><title>What are the main priorities now?</title><p>First, universal access to cART still remains the major priority for the management of patients with HIV. cART will always be a part of any strategy that may lead to a cure. Second, there is an urgent need for clinical trials. There are several compounds that look promising in the laboratory, including vorinostat and IL-7. It is highly likely that a combination of approaches will be needed together with cART intensification. These studies are likely to have the greatest possibility of success in patients who initiated cART shortly after acute infection.</p><p>Importantly, more active community engagement in this work is critical. Basic science issues are often perceived as highly technical and without impact on the daily lives of infected or affected communities. It is, however, crucial for community representatives and basic science researchers to work together to systematically address the barriers and challenges that hold us back from finding a cure.</p><p>Clinical trials will be needed to move the field forward and it is essential that affected communities are involved in these efforts as true partners. For example, it is important that community representatives are involved in longer term strategic planning for eradication studies, as well as the planning of individual studies. Community members should be invited to join the steering committees, advisory boards, and data safety and monitoring boards of these studies. Additionally, they should join together with health professionals in raising the awareness and understanding of issues related to HIV persistence and potential eradication. Such an alliance will also be critical for increasing the funding support for basic science research in the field of HIV.</p><p>As we move forward into clinical trials, we also need to carefully consider what the most appropriate endpoints should be. Can we use surrogate markers of the reservoir, including HIV DNA and plasma viremia? Are there circumstances in which it will be acceptable to trial treatment interruption with the well-documented risks of viral rebound [<xref ref-type="bibr" rid="B84">84</xref>]?</p></sec></sec><sec sec-type="conclusions"><title>Conclusions</title><p>We should not continue to accept that HIV is a long-term chronic illness that commits patients to life-long treatment and associated toxicities. We should not accept that life-long treatment may not be available to all who need it. A cure will need a great scientific advance, but we will not achieve a cure with science alone. We need scientists, clinicians, affected communities, industry, politicians and government to embrace the challenge and work together towards finding a cure for HIV.</p></sec><sec><title>Competing interests</title><p>The authors declare that they have no competing interests.</p></sec><sec><title>Authors' contributions</title><p>SRL wrote the manuscript. VAE prepared the figure and table and contributed to the critical revision of the manuscript. JHE, BS and NC reviewed the manuscript and provided helpful comments. All authors read and approved the final manuscript.</p></sec></body><back><sec><title>Acknowledgements</title><p>This article is based in parts on the plenary talk by Sharon Lewin presented at the XVIII International AIDS Conference in Vienna, Austria (July 2010).</p></sec><ref-list><ref id="B1"><mixed-citation publication-type="journal"><name><surname>Mocroft</surname><given-names>A</given-names></name><name><surname>Ledergerber</surname><given-names>B</given-names></name><name><surname>Katlama</surname><given-names>C</given-names></name><name><surname>Kirk</surname><given-names>O</given-names></name><name><surname>Reiss</surname><given-names>P</given-names></name><name><surname>d'Arminio Monforte</surname><given-names>A</given-names></name><name><surname>Knysz</surname><given-names>B</given-names></name><name><surname>Dietrich</surname><given-names>M</given-names></name><name><surname>Phillips</surname><given-names>AN</given-names></name><name><surname>Lundgren</surname><given-names>JD</given-names></name><article-title>Decline in the AIDS and death rates in the EuroSIDA study: an observational study</article-title><source>Lancet</source><year>2003</year><volume>14</volume><fpage>22</fpage><lpage>29</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(03)13802-0</pub-id><pub-id pub-id-type="pmid">12853195</pub-id></mixed-citation></ref><ref id="B2"><mixed-citation publication-type="journal"><name><surname>Palella</surname><given-names>FJ</given-names><suffix>Jr</suffix></name><name><surname>Delaney</surname><given-names>KM</given-names></name><name><surname>Moorman</surname><given-names>AC</given-names></name><name><surname>Loveless</surname><given-names>MO</given-names></name><name><surname>Fuhrer</surname><given-names>J</given-names></name><name><surname>Satten</surname><given-names>GA</given-names></name><name><surname>Aschman</surname><given-names>DJ</given-names></name><name><surname>Holmberg</surname><given-names>SD</given-names></name><article-title>Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators</article-title><source>The New England Journal of Medicine</source><year>1998</year><volume>14</volume><fpage>853</fpage><lpage>860</lpage><pub-id pub-id-type="doi">10.1056/NEJM199803263381301</pub-id><pub-id pub-id-type="pmid">9516219</pub-id></mixed-citation></ref><ref id="B3"><mixed-citation publication-type="journal"><name><surname>Braitstein</surname><given-names>P</given-names></name><name><surname>Brinkhof</surname><given-names>MW</given-names></name><name><surname>Dabis</surname><given-names>F</given-names></name><name><surname>Schechter</surname><given-names>M</given-names></name><name><surname>Boulle</surname><given-names>A</given-names></name><name><surname>Miotti</surname><given-names>P</given-names></name><name><surname>Wood</surname><given-names>R</given-names></name><name><surname>Laurent</surname><given-names>C</given-names></name><name><surname>Sprinz</surname><given-names>E</given-names></name><name><surname>Seyler</surname><given-names>C</given-names></name><name><surname>Bangsberg</surname><given-names>DR</given-names></name><name><surname>Balestre</surname><given-names>E</given-names></name><name><surname>Sterne</surname><given-names>JA</given-names></name><name><surname>May</surname><given-names>M</given-names></name><name><surname>Egger</surname><given-names>M</given-names></name><article-title>Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries</article-title><source>Lancet</source><year>2006</year><volume>14</volume><fpage>817</fpage><lpage>824</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(06)68337-2</pub-id><pub-id pub-id-type="pmid">16530575</pub-id></mixed-citation></ref><ref id="B4"><mixed-citation publication-type="other"><collab>WHO, UNAIDS, UNICEF</collab><source>Towards universal access: scaling up priority HIV/AIDS interventions in the health sector: Progress report</source><year>2010</year><ext-link ext-link-type="uri" xlink:href="http://www.who.int/hiv/mediacentre/universal_access_progress_report_en.pdf">http://www.who.int/hiv/mediacentre/universal_access_progress_report_en.pdf</ext-link></mixed-citation></ref><ref id="B5"><mixed-citation publication-type="journal"><name><surname>Lohse</surname><given-names>N</given-names></name><name><surname>Hansen</surname><given-names>AB</given-names></name><name><surname>Pedersen</surname><given-names>G</given-names></name><name><surname>Kronborg</surname><given-names>G</given-names></name><name><surname>Gerstoft</surname><given-names>J</given-names></name><name><surname>Sorensen</surname><given-names>HT</given-names></name><name><surname>Vaeth</surname><given-names>M</given-names></name><name><surname>Obel</surname><given-names>N</given-names></name><article-title>Survival of persons with and without HIV infection in Denmark, 1995-2005</article-title><source>Ann Intern Med</source><year>2007</year><volume>14</volume><fpage>87</fpage><lpage>95</lpage><pub-id pub-id-type="pmid">17227932</pub-id></mixed-citation></ref><ref id="B6"><mixed-citation publication-type="journal"><name><surname>Neuhaus</surname><given-names>J</given-names></name><name><surname>Angus</surname><given-names>B</given-names></name><name><surname>Kowalska</surname><given-names>JD</given-names></name><name><surname>La Rosa</surname><given-names>A</given-names></name><name><surname>Sampson</surname><given-names>J</given-names></name><name><surname>Wentworth</surname><given-names>D</given-names></name><name><surname>Mocroft</surname><given-names>A</given-names></name><article-title>Risk of all-cause mortality associated with nonfatal AIDS and serious non-AIDS events among adults infected with HIV</article-title><source>AIDS</source><year>2010</year><volume>14</volume><fpage>697</fpage><lpage>706</lpage><pub-id pub-id-type="doi">10.1097/QAD.0b013e3283365356</pub-id><pub-id pub-id-type="pmid">20177360</pub-id></mixed-citation></ref><ref id="B7"><mixed-citation publication-type="journal"><name><surname>Friis-Moller</surname><given-names>N</given-names></name><name><surname>Sabin</surname><given-names>CA</given-names></name><name><surname>Weber</surname><given-names>R</given-names></name><name><surname>d'Arminio Monforte</surname><given-names>A</given-names></name><name><surname>El-Sadr</surname><given-names>WM</given-names></name><name><surname>Reiss</surname><given-names>P</given-names></name><name><surname>Thiebaut</surname><given-names>R</given-names></name><name><surname>Morfeldt</surname><given-names>L</given-names></name><name><surname>De Wit</surname><given-names>S</given-names></name><name><surname>Pradier</surname><given-names>C</given-names></name><name><surname>Calvo</surname><given-names>G</given-names></name><name><surname>Law</surname><given-names>MG</given-names></name><name><surname>Kirk</surname><given-names>O</given-names></name><name><surname>Phillips</surname><given-names>AN</given-names></name><name><surname>Lundgren</surname><given-names>JD</given-names></name><article-title>Combination antiretroviral therapy and the risk of myocardial infarction</article-title><source>The New England Journal of Medicine</source><year>2003</year><volume>14</volume><fpage>1993</fpage><lpage>2003</lpage><pub-id pub-id-type="doi">10.1056/NEJMoa030218</pub-id><pub-id pub-id-type="pmid">14627784</pub-id></mixed-citation></ref><ref id="B8"><mixed-citation publication-type="journal"><name><surname>Neuhaus</surname><given-names>J</given-names></name><name><surname>Jacobs</surname><given-names>DR</given-names><suffix>Jr</suffix></name><name><surname>Baker</surname><given-names>JV</given-names></name><name><surname>Calmy</surname><given-names>A</given-names></name><name><surname>Duprez</surname><given-names>D</given-names></name><name><surname>La Rosa</surname><given-names>A</given-names></name><name><surname>Kuller</surname><given-names>LH</given-names></name><name><surname>Pett</surname><given-names>SL</given-names></name><name><surname>Ristola</surname><given-names>M</given-names></name><name><surname>Ross</surname><given-names>MJ</given-names></name><name><surname>Shlipak</surname><given-names>MG</given-names></name><name><surname>Tracy</surname><given-names>R</given-names></name><name><surname>Neaton</surname><given-names>JD</given-names></name><article-title>Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection</article-title><source>J Infect Dis</source><year>2010</year><volume>14</volume><fpage>1788</fpage><lpage>1795</lpage><pub-id pub-id-type="doi">10.1086/652749</pub-id><pub-id pub-id-type="pmid">20446848</pub-id></mixed-citation></ref><ref id="B9"><mixed-citation publication-type="journal"><name><surname>Friis-Moller</surname><given-names>N</given-names></name><name><surname>Weber</surname><given-names>R</given-names></name><name><surname>Reiss</surname><given-names>P</given-names></name><name><surname>Thiebaut</surname><given-names>R</given-names></name><name><surname>Kirk</surname><given-names>O</given-names></name><name><surname>d'Arminio Monforte</surname><given-names>A</given-names></name><name><surname>Pradier</surname><given-names>C</given-names></name><name><surname>Morfeldt</surname><given-names>L</given-names></name><name><surname>Mateu</surname><given-names>S</given-names></name><name><surname>Law</surname><given-names>M</given-names></name><name><surname>El-Sadr</surname><given-names>W</given-names></name><name><surname>De Wit</surname><given-names>S</given-names></name><name><surname>Sabin</surname><given-names>CA</given-names></name><name><surname>Phillips</surname><given-names>AN</given-names></name><name><surname>Lundgren</surname><given-names>JD</given-names></name><article-title>Cardiovascular disease risk factors in HIV patients--association with antiretroviral therapy. Results from the DAD study</article-title><source>AIDS</source><year>2003</year><volume>14</volume><fpage>1179</fpage><lpage>1193</lpage><pub-id pub-id-type="doi">10.1097/00002030-200305230-00010</pub-id><pub-id pub-id-type="pmid">12819520</pub-id></mixed-citation></ref><ref id="B10"><mixed-citation publication-type="journal"><name><surname>Deeks</surname><given-names>SG</given-names></name><name><surname>Phillips</surname><given-names>AN</given-names></name><article-title>HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity</article-title><source>BMJ</source><year>2009</year><volume>14</volume><fpage>a3172</fpage><pub-id pub-id-type="doi">10.1136/bmj.a3172</pub-id><pub-id pub-id-type="pmid">19171560</pub-id></mixed-citation></ref><ref id="B11"><mixed-citation publication-type="other"><collab>World Health Organization</collab><article-title>Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach</article-title><year>2010</year><ext-link ext-link-type="uri" xlink:href="http://www.who.int/hiv/pub/arv/adult2010/en/index.html">http://www.who.int/hiv/pub/arv/adult2010/en/index.html</ext-link></mixed-citation></ref><ref id="B12"><mixed-citation publication-type="other"><collab>Department of Health and Human Services (DHHS)</collab><article-title>Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services</article-title><year>2009</year><ext-link ext-link-type="uri" xlink:href="http://aidsinfo.nih.gov/contentfiles/AdultandAdolescentGL.pdf">http://aidsinfo.nih.gov/contentfiles/AdultandAdolescentGL.pdf</ext-link></mixed-citation></ref><ref id="B13"><mixed-citation publication-type="journal"><name><surname>Bongaarts</surname><given-names>J</given-names></name><name><surname>Over</surname><given-names>M</given-names></name><article-title>Public health. Global HIV/AIDS policy in transition</article-title><source>Science</source><year>2010</year><volume>14</volume><fpage>1359</fpage><lpage>1360</lpage><pub-id pub-id-type="doi">10.1126/science.1191804</pub-id><pub-id pub-id-type="pmid">20538936</pub-id></mixed-citation></ref><ref id="B14"><mixed-citation publication-type="other"><collab>UNAIDS</collab><article-title>AIDS Epidemic Update</article-title><year>2009</year></mixed-citation></ref><ref id="B15"><mixed-citation publication-type="journal"><name><surname>Abdool Karim</surname><given-names>Q</given-names></name><name><surname>Abdool Karim</surname><given-names>SS</given-names></name><name><surname>Frohlich</surname><given-names>JA</given-names></name><name><surname>Grobler</surname><given-names>AC</given-names></name><name><surname>Baxter</surname><given-names>C</given-names></name><name><surname>Mansoor</surname><given-names>LE</given-names></name><name><surname>Kharsany</surname><given-names>AB</given-names></name><name><surname>Sibeko</surname><given-names>S</given-names></name><name><surname>Mlisana</surname><given-names>KP</given-names></name><name><surname>Omar</surname><given-names>Z</given-names></name><name><surname>Gengiah</surname><given-names>TN</given-names></name><name><surname>Maarschalk</surname><given-names>S</given-names></name><name><surname>Arulappan</surname><given-names>N</given-names></name><name><surname>Mlotshwa</surname><given-names>M</given-names></name><name><surname>Morris</surname><given-names>L</given-names></name><name><surname>Taylor</surname><given-names>D</given-names></name><article-title>Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women</article-title><source>Science</source><year>2010</year><volume>14</volume><fpage>1168</fpage><lpage>1174</lpage><pub-id pub-id-type="doi">10.1126/science.1193748</pub-id><pub-id pub-id-type="pmid">20643915</pub-id></mixed-citation></ref><ref id="B16"><mixed-citation publication-type="journal"><name><surname>Auvert</surname><given-names>B</given-names></name><name><surname>Taljaard</surname><given-names>D</given-names></name><name><surname>Lagarde</surname><given-names>E</given-names></name><name><surname>Sobngwi-Tambekou</surname><given-names>J</given-names></name><name><surname>Sitta</surname><given-names>R</given-names></name><name><surname>Puren</surname><given-names>A</given-names></name><article-title>Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial</article-title><source>PLoS Medicine</source><year>2005</year><volume>14</volume><fpage>e298</fpage><pub-id pub-id-type="doi">10.1371/journal.pmed.0020298</pub-id><pub-id pub-id-type="pmid">16231970</pub-id></mixed-citation></ref><ref id="B17"><mixed-citation publication-type="journal"><name><surname>Hecht</surname><given-names>R</given-names></name><name><surname>Bollinger</surname><given-names>L</given-names></name><name><surname>Stover</surname><given-names>J</given-names></name><name><surname>McGreevey</surname><given-names>W</given-names></name><name><surname>Muhib</surname><given-names>F</given-names></name><name><surname>Madavo</surname><given-names>CE</given-names></name><name><surname>de Ferranti</surname><given-names>D</given-names></name><article-title>Critical choices in financing the response to the global HIV/AIDS pandemic</article-title><source>Health Aff (Millwood)</source><year>2009</year><volume>14</volume><fpage>1591</fpage><lpage>1605</lpage><pub-id pub-id-type="doi">10.1377/hlthaff.28.6.1591</pub-id><pub-id pub-id-type="pmid">19887401</pub-id></mixed-citation></ref><ref id="B18"><mixed-citation publication-type="journal"><name><surname>Chun</surname><given-names>TW</given-names></name><name><surname>Carruth</surname><given-names>L</given-names></name><name><surname>Finzi</surname><given-names>D</given-names></name><name><surname>Shen</surname><given-names>X</given-names></name><name><surname>DiGiuseppe</surname><given-names>JA</given-names></name><name><surname>Taylor</surname><given-names>H</given-names></name><name><surname>Hermankova</surname><given-names>M</given-names></name><name><surname>Chadwick</surname><given-names>K</given-names></name><name><surname>Margolick</surname><given-names>J</given-names></name><name><surname>Quinn</surname><given-names>TC</given-names></name><name><surname>Kuo</surname><given-names>YH</given-names></name><name><surname>Brookmeyer</surname><given-names>R</given-names></name><name><surname>Zeiger</surname><given-names>MA</given-names></name><name><surname>Barditch-Crovo</surname><given-names>P</given-names></name><name><surname>Siliciano</surname><given-names>RF</given-names></name><article-title>Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection</article-title><source>Nature</source><year>1997</year><volume>14</volume><fpage>183</fpage><lpage>188</lpage><pub-id pub-id-type="doi">10.1038/387183a0</pub-id><pub-id pub-id-type="pmid">9144289</pub-id></mixed-citation></ref><ref id="B19"><mixed-citation publication-type="journal"><name><surname>Finzi</surname><given-names>D</given-names></name><name><surname>Blankson</surname><given-names>J</given-names></name><name><surname>Siliciano</surname><given-names>J</given-names></name><name><surname>Margolick</surname><given-names>J</given-names></name><name><surname>Chadwick</surname><given-names>K</given-names></name><name><surname>Pierson</surname><given-names>T</given-names></name><name><surname>Smith</surname><given-names>K</given-names></name><name><surname>Lisziewicz</surname><given-names>J</given-names></name><name><surname>Lori</surname><given-names>F</given-names></name><name><surname>Flexner</surname><given-names>C</given-names></name><name><surname>Quinn</surname><given-names>T</given-names></name><name><surname>Chaisson</surname><given-names>R</given-names></name><name><surname>Rosenberg</surname><given-names>E</given-names></name><name><surname>Walker</surname><given-names>B</given-names></name><name><surname>Gange</surname><given-names>S</given-names></name><name><surname>Gallant</surname><given-names>J</given-names></name><name><surname>Siliciano</surname><given-names>R</given-names></name><article-title>Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy</article-title><source>Nat Med</source><year>1999</year><volume>14</volume><fpage>512</fpage><lpage>517</lpage><pub-id pub-id-type="doi">10.1038/8394</pub-id><pub-id pub-id-type="pmid">10229227</pub-id></mixed-citation></ref><ref id="B20"><mixed-citation publication-type="journal"><name><surname>Wong</surname><given-names>J</given-names></name><name><surname>Hezareh</surname><given-names>M</given-names></name><name><surname>Gunthard</surname><given-names>H</given-names></name><name><surname>Havlir</surname><given-names>D</given-names></name><name><surname>Ignacio</surname><given-names>C</given-names></name><name><surname>Spina</surname><given-names>C</given-names></name><name><surname>Richman</surname><given-names>D</given-names></name><article-title>Recovery of replication-competent HIV despite prolonged suppression of plasma viremia</article-title><source>Science</source><year>1997</year><volume>14</volume><fpage>1291</fpage><lpage>1294</lpage><pub-id pub-id-type="doi">10.1126/science.278.5341.1291</pub-id><pub-id pub-id-type="pmid">9360926</pub-id></mixed-citation></ref><ref id="B21"><mixed-citation publication-type="journal"><name><surname>Palmer</surname><given-names>S</given-names></name><name><surname>Maldarelli</surname><given-names>F</given-names></name><name><surname>Wiegand</surname><given-names>A</given-names></name><name><surname>Bernstein</surname><given-names>B</given-names></name><name><surname>Hanna</surname><given-names>GJ</given-names></name><name><surname>Brun</surname><given-names>SC</given-names></name><name><surname>Kempf</surname><given-names>DJ</given-names></name><name><surname>Mellors</surname><given-names>JW</given-names></name><name><surname>Coffin</surname><given-names>JM</given-names></name><name><surname>King</surname><given-names>MS</given-names></name><article-title>Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy</article-title><source>Proc Natl Acad Sci USA</source><year>2008</year><volume>14</volume><fpage>3879</fpage><lpage>3884</lpage><pub-id pub-id-type="doi">10.1073/pnas.0800050105</pub-id><pub-id pub-id-type="pmid">18332425</pub-id></mixed-citation></ref><ref id="B22"><mixed-citation publication-type="journal"><name><surname>Maldarelli</surname><given-names>F</given-names></name><name><surname>Palmer</surname><given-names>S</given-names></name><name><surname>King</surname><given-names>MS</given-names></name><name><surname>Wiegand</surname><given-names>A</given-names></name><name><surname>Polis</surname><given-names>MA</given-names></name><name><surname>Mican</surname><given-names>J</given-names></name><name><surname>Kovacs</surname><given-names>JA</given-names></name><name><surname>Davey</surname><given-names>RT</given-names></name><name><surname>Rock-Kress</surname><given-names>D</given-names></name><name><surname>Dewar</surname><given-names>R</given-names></name><name><surname>Liu</surname><given-names>S</given-names></name><name><surname>Metcalf</surname><given-names>JA</given-names></name><name><surname>Rehm</surname><given-names>C</given-names></name><name><surname>Brun</surname><given-names>SC</given-names></name><name><surname>Hanna</surname><given-names>GJ</given-names></name><name><surname>Kempf</surname><given-names>DJ</given-names></name><name><surname>Coffin</surname><given-names>JM</given-names></name><name><surname>Mellors</surname><given-names>JW</given-names></name><article-title>ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia</article-title><source>PLoS Pathog</source><year>2007</year><volume>14</volume><fpage>e46</fpage><pub-id pub-id-type="doi">10.1371/journal.ppat.0030046</pub-id><pub-id pub-id-type="pmid">17411338</pub-id></mixed-citation></ref><ref id="B23"><mixed-citation publication-type="journal"><name><surname>Sonza</surname><given-names>S</given-names></name><name><surname>Mutimer</surname><given-names>HP</given-names></name><name><surname>Oelrichs</surname><given-names>R</given-names></name><name><surname>Jardine</surname><given-names>D</given-names></name><name><surname>Harvey</surname><given-names>K</given-names></name><name><surname>Dunne</surname><given-names>A</given-names></name><name><surname>Purcell</surname><given-names>DF</given-names></name><name><surname>Birch</surname><given-names>C</given-names></name><name><surname>Crowe</surname><given-names>SM</given-names></name><article-title>Monocytes harbour replication-competent, non-latent HIV-1 in patients on highly active antiretroviral therapy</article-title><source>AIDS</source><year>2001</year><volume>14</volume><fpage>17</fpage><lpage>22</lpage><pub-id pub-id-type="doi">10.1097/00002030-200101050-00005</pub-id><pub-id pub-id-type="pmid">11192864</pub-id></mixed-citation></ref><ref id="B24"><mixed-citation publication-type="journal"><name><surname>Gorry</surname><given-names>P</given-names></name><name><surname>Purcell</surname><given-names>D</given-names></name><name><surname>Howard</surname><given-names>J</given-names></name><name><surname>McPhee</surname><given-names>D</given-names></name><article-title>Restricted HIV-1 infection of human astrocytes: potential role of nef in the regulation of virus replication</article-title><source>Journal of Neurovirology</source><year>1998</year><volume>14</volume><fpage>377</fpage><lpage>386</lpage><pub-id pub-id-type="doi">10.3109/13550289809114536</pub-id><pub-id pub-id-type="pmid">9718129</pub-id></mixed-citation></ref><ref id="B25"><mixed-citation publication-type="journal"><name><surname>Churchill</surname><given-names>MJ</given-names></name><name><surname>Wesselingh</surname><given-names>SL</given-names></name><name><surname>Cowley</surname><given-names>D</given-names></name><name><surname>Pardo</surname><given-names>CA</given-names></name><name><surname>McArthur</surname><given-names>JC</given-names></name><name><surname>Brew</surname><given-names>BJ</given-names></name><name><surname>Gorry</surname><given-names>PR</given-names></name><article-title>Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia</article-title><source>Annals of Neurology</source><year>2009</year><volume>14</volume><fpage>253</fpage><lpage>258</lpage><pub-id pub-id-type="doi">10.1002/ana.21697</pub-id><pub-id pub-id-type="pmid">19743454</pub-id></mixed-citation></ref><ref id="B26"><mixed-citation publication-type="journal"><name><surname>Zack</surname><given-names>JA</given-names></name><name><surname>Haislip</surname><given-names>AM</given-names></name><name><surname>Krogstad</surname><given-names>P</given-names></name><name><surname>Chen</surname><given-names>IS</given-names></name><article-title>Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle</article-title><source>J Virol</source><year>1992</year><volume>14</volume><fpage>1717</fpage><lpage>1725</lpage><pub-id pub-id-type="pmid">1371173</pub-id></mixed-citation></ref><ref id="B27"><mixed-citation publication-type="journal"><name><surname>Chomont</surname><given-names>N</given-names></name><name><surname>El-Far</surname><given-names>M</given-names></name><name><surname>Ancuta</surname><given-names>P</given-names></name><name><surname>Trautmann</surname><given-names>L</given-names></name><name><surname>Procopio</surname><given-names>FA</given-names></name><name><surname>Yassine-Diab</surname><given-names>B</given-names></name><name><surname>Boucher</surname><given-names>G</given-names></name><name><surname>Boulassel</surname><given-names>MR</given-names></name><name><surname>Ghattas</surname><given-names>G</given-names></name><name><surname>Brenchley</surname><given-names>JM</given-names></name><name><surname>Schacker</surname><given-names>TW</given-names></name><name><surname>Hill</surname><given-names>BJ</given-names></name><name><surname>Douek</surname><given-names>DC</given-names></name><name><surname>Routy</surname><given-names>JP</given-names></name><name><surname>Haddad</surname><given-names>EK</given-names></name><name><surname>Sekaly</surname><given-names>RP</given-names></name><article-title>HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation</article-title><source>Nat Med</source><year>2009</year><volume>14</volume><fpage>893</fpage><lpage>900</lpage><pub-id pub-id-type="doi">10.1038/nm.1972</pub-id><pub-id pub-id-type="pmid">19543283</pub-id></mixed-citation></ref><ref id="B28"><mixed-citation publication-type="journal"><name><surname>Finzi</surname><given-names>D</given-names></name><name><surname>Hermankova</surname><given-names>M</given-names></name><name><surname>Pierson</surname><given-names>T</given-names></name><name><surname>Carruth</surname><given-names>L</given-names></name><name><surname>Buck</surname><given-names>C</given-names></name><name><surname>Chaisson</surname><given-names>R</given-names></name><name><surname>Quinn</surname><given-names>T</given-names></name><name><surname>Chadwick</surname><given-names>K</given-names></name><name><surname>Margolick</surname><given-names>J</given-names></name><name><surname>Brookmeyer</surname><given-names>R</given-names></name><name><surname>Gallant</surname><given-names>J</given-names></name><name><surname>Markowitz</surname><given-names>M</given-names></name><name><surname>Ho</surname><given-names>D</given-names></name><name><surname>Richman</surname><given-names>D</given-names></name><name><surname>Silicano</surname><given-names>R</given-names></name><article-title>Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy</article-title><source>Science</source><year>1997</year><volume>14</volume><fpage>1295</fpage><lpage>1300</lpage><pub-id pub-id-type="doi">10.1126/science.278.5341.1295</pub-id><pub-id pub-id-type="pmid">9360927</pub-id></mixed-citation></ref><ref id="B29"><mixed-citation publication-type="journal"><name><surname>Siliciano</surname><given-names>JD</given-names></name><name><surname>Kajdas</surname><given-names>J</given-names></name><name><surname>Finzi</surname><given-names>D</given-names></name><name><surname>Quinn</surname><given-names>TC</given-names></name><name><surname>Chadwick</surname><given-names>K</given-names></name><name><surname>Margolick</surname><given-names>JB</given-names></name><name><surname>Kovacs</surname><given-names>C</given-names></name><name><surname>Gange</surname><given-names>SJ</given-names></name><name><surname>Siliciano</surname><given-names>RF</given-names></name><article-title>Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells</article-title><source>Nat Med</source><year>2003</year><volume>14</volume><fpage>727</fpage><lpage>728</lpage><pub-id pub-id-type="doi">10.1038/nm880</pub-id><pub-id pub-id-type="pmid">12754504</pub-id></mixed-citation></ref><ref id="B30"><mixed-citation publication-type="journal"><name><surname>Zack</surname><given-names>J</given-names></name><name><surname>Arrigo</surname><given-names>S</given-names></name><name><surname>Weitsman</surname><given-names>S</given-names></name><name><surname>Go</surname><given-names>A</given-names></name><name><surname>Haislip</surname><given-names>A</given-names></name><name><surname>Chen</surname><given-names>I</given-names></name><article-title>HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure</article-title><source>Cell</source><year>1990</year><volume>14</volume><fpage>213</fpage><lpage>222</lpage><pub-id pub-id-type="doi">10.1016/0092-8674(90)90802-L</pub-id><pub-id pub-id-type="pmid">2331748</pub-id></mixed-citation></ref><ref id="B31"><mixed-citation publication-type="journal"><name><surname>Bukrinsky</surname><given-names>MI</given-names></name><name><surname>Sharova</surname><given-names>N</given-names></name><name><surname>Dempsey</surname><given-names>MP</given-names></name><name><surname>Stanwick</surname><given-names>TL</given-names></name><name><surname>Bukrinskaya</surname><given-names>AG</given-names></name><name><surname>Haggerty</surname><given-names>S</given-names></name><name><surname>Stevenson</surname><given-names>M</given-names></name><article-title>Active nuclear import of human immunodeficiency virus type 1 preintegration complexes</article-title><source>Proc Natl Acad Sci USA</source><year>1992</year><volume>14</volume><fpage>6580</fpage><lpage>6584</lpage><pub-id pub-id-type="doi">10.1073/pnas.89.14.6580</pub-id><pub-id pub-id-type="pmid">1631159</pub-id></mixed-citation></ref><ref id="B32"><mixed-citation publication-type="journal"><name><surname>Musey</surname><given-names>LK</given-names></name><name><surname>Krieger</surname><given-names>JN</given-names></name><name><surname>Hughes</surname><given-names>JP</given-names></name><name><surname>Schacker</surname><given-names>TW</given-names></name><name><surname>Corey</surname><given-names>L</given-names></name><name><surname>McElrath</surname><given-names>MJ</given-names></name><article-title>Early and persistent human immunodeficiency virus type 1 (HIV-1)-specific T helper dysfunction in blood and lymph nodes following acute HIV-1 infection</article-title><source>J Infect Dis</source><year>1999</year><volume>14</volume><fpage>278</fpage><lpage>284</lpage><pub-id pub-id-type="doi">10.1086/314868</pub-id><pub-id pub-id-type="pmid">10395840</pub-id></mixed-citation></ref><ref id="B33"><mixed-citation publication-type="journal"><name><surname>Zhang</surname><given-names>Z</given-names></name><name><surname>Schuler</surname><given-names>T</given-names></name><name><surname>Zupancic</surname><given-names>M</given-names></name><name><surname>Wietgrefe</surname><given-names>S</given-names></name><name><surname>Staskus</surname><given-names>KA</given-names></name><name><surname>Reimann</surname><given-names>KA</given-names></name><name><surname>Reinhart</surname><given-names>TA</given-names></name><name><surname>Rogan</surname><given-names>M</given-names></name><name><surname>Cavert</surname><given-names>W</given-names></name><name><surname>Miller</surname><given-names>CJ</given-names></name><name><surname>Veazey</surname><given-names>RS</given-names></name><name><surname>Notermans</surname><given-names>D</given-names></name><name><surname>Little</surname><given-names>S</given-names></name><name><surname>Danner</surname><given-names>SA</given-names></name><name><surname>Richman</surname><given-names>DD</given-names></name><name><surname>Havlir</surname><given-names>D</given-names></name><name><surname>Wong</surname><given-names>J</given-names></name><name><surname>Jordan</surname><given-names>HL</given-names></name><name><surname>Schacker</surname><given-names>TW</given-names></name><name><surname>Racz</surname><given-names>P</given-names></name><name><surname>Tenner-Racz</surname><given-names>K</given-names></name><name><surname>Letvin</surname><given-names>NL</given-names></name><name><surname>Wolinsky</surname><given-names>S</given-names></name><name><surname>Haase</surname><given-names>AT</given-names></name><article-title>Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells</article-title><source>Science</source><year>1999</year><volume>14</volume><fpage>1353</fpage><lpage>1357</lpage><pub-id pub-id-type="doi">10.1126/science.286.5443.1353</pub-id><pub-id pub-id-type="pmid">10558989</pub-id></mixed-citation></ref><ref id="B34"><mixed-citation publication-type="journal"><name><surname>Audige</surname><given-names>A</given-names></name><name><surname>Schlaepfer</surname><given-names>E</given-names></name><name><surname>Bonanomi</surname><given-names>A</given-names></name><name><surname>Joller</surname><given-names>H</given-names></name><name><surname>Knuchel</surname><given-names>MC</given-names></name><name><surname>Weber</surname><given-names>M</given-names></name><name><surname>Nadal</surname><given-names>D</given-names></name><name><surname>Speck</surname><given-names>RF</given-names></name><article-title>HIV-1 does not provoke alteration of cytokine gene expression in lymphoid tissue after acute infection ex vivo</article-title><source>J Immunol</source><year>2004</year><volume>14</volume><fpage>2687</fpage><lpage>2696</lpage><pub-id pub-id-type="pmid">14764744</pub-id></mixed-citation></ref><ref id="B35"><mixed-citation publication-type="journal"><name><surname>Eckstein</surname><given-names>DA</given-names></name><name><surname>Penn</surname><given-names>ML</given-names></name><name><surname>Korin</surname><given-names>YD</given-names></name><name><surname>Scripture-Adams</surname><given-names>DD</given-names></name><name><surname>Zack</surname><given-names>JA</given-names></name><name><surname>Kreisberg</surname><given-names>JF</given-names></name><name><surname>Roederer</surname><given-names>M</given-names></name><name><surname>Sherman</surname><given-names>MP</given-names></name><name><surname>Chin</surname><given-names>PS</given-names></name><name><surname>Goldsmith</surname><given-names>MA</given-names></name><article-title>HIV-1 Actively Replicates in Naive CD4(+) T Cells Residing within Human Lymphoid Tissues</article-title><source>Immunity</source><year>2001</year><volume>14</volume><fpage>671</fpage><lpage>682</lpage><pub-id pub-id-type="doi">10.1016/S1074-7613(01)00217-5</pub-id><pub-id pub-id-type="pmid">11672548</pub-id></mixed-citation></ref><ref id="B36"><mixed-citation publication-type="journal"><name><surname>Saleh</surname><given-names>S</given-names></name><name><surname>Solomon</surname><given-names>A</given-names></name><name><surname>Wightman</surname><given-names>F</given-names></name><name><surname>Xhilaga</surname><given-names>M</given-names></name><name><surname>Cameron</surname><given-names>PU</given-names></name><name><surname>Lewin</surname><given-names>SR</given-names></name><article-title>CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency</article-title><source>Blood</source><year>2007</year><volume>14</volume><fpage>4161</fpage><lpage>4164</lpage><pub-id pub-id-type="doi">10.1182/blood-2007-06-097907</pub-id><pub-id pub-id-type="pmid">17881634</pub-id></mixed-citation></ref><ref id="B37"><mixed-citation publication-type="journal"><name><surname>Cameron</surname><given-names>P</given-names></name><name><surname>Saleh</surname><given-names>S</given-names></name><name><surname>Sallmann</surname><given-names>G</given-names></name><name><surname>Solomon</surname><given-names>A</given-names></name><name><surname>Wightman</surname><given-names>F</given-names></name><name><surname>Evans</surname><given-names>V</given-names></name><name><surname>Boucher</surname><given-names>G</given-names></name><name><surname>Haddad</surname><given-names>E</given-names></name><name><surname>Sekaly</surname><given-names>R</given-names></name><name><surname>Harman</surname><given-names>A</given-names></name><name><surname>Anderson</surname><given-names>J</given-names></name><name><surname>Jones</surname><given-names>K</given-names></name><name><surname>Mak</surname><given-names>J</given-names></name><name><surname>Cunningham</surname><given-names>A</given-names></name><name><surname>Jaworowski</surname><given-names>A</given-names></name><name><surname>Lewin</surname><given-names>S</given-names></name><article-title>Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine induced changes in the actin cytoskeleton</article-title><source>Proc Natl Acad Sci USA</source><year>2010</year><volume>14</volume><fpage>16934</fpage><lpage>16939</lpage><pub-id pub-id-type="doi">10.1073/pnas.1002894107</pub-id><pub-id pub-id-type="pmid">20837531</pub-id></mixed-citation></ref><ref id="B38"><mixed-citation publication-type="journal"><name><surname>Bosque</surname><given-names>A</given-names></name><name><surname>Planelles</surname><given-names>V</given-names></name><article-title>Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells</article-title><source>Blood</source><year>2009</year><volume>14</volume><fpage>58</fpage><lpage>65</lpage><pub-id pub-id-type="doi">10.1182/blood-2008-07-168393</pub-id><pub-id pub-id-type="pmid">18849485</pub-id></mixed-citation></ref><ref id="B39"><mixed-citation publication-type="journal"><name><surname>Marini</surname><given-names>A</given-names></name><name><surname>Harper</surname><given-names>JM</given-names></name><name><surname>Romerio</surname><given-names>F</given-names></name><article-title>An in vitro system to model the establishment and reactivation of HIV-1 latency</article-title><source>J Immunol</source><year>2008</year><volume>14</volume><fpage>7713</fpage><lpage>7720</lpage><pub-id pub-id-type="pmid">19017960</pub-id></mixed-citation></ref><ref id="B40"><mixed-citation publication-type="journal"><name><surname>Yang</surname><given-names>HC</given-names></name><name><surname>Xing</surname><given-names>S</given-names></name><name><surname>Shan</surname><given-names>L</given-names></name><name><surname>O'Connell</surname><given-names>K</given-names></name><name><surname>Dinoso</surname><given-names>J</given-names></name><name><surname>Shen</surname><given-names>A</given-names></name><name><surname>Zhou</surname><given-names>Y</given-names></name><name><surname>Shrum</surname><given-names>CK</given-names></name><name><surname>Han</surname><given-names>Y</given-names></name><name><surname>Liu</surname><given-names>JO</given-names></name><name><surname>Zhang</surname><given-names>H</given-names></name><name><surname>Margolick</surname><given-names>JB</given-names></name><name><surname>Siliciano</surname><given-names>RF</given-names></name><article-title>Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation</article-title><source>J Clin Invest</source><year>2009</year><volume>14</volume><fpage>3473</fpage><lpage>3486</lpage><pub-id pub-id-type="pmid">19805909</pub-id></mixed-citation></ref><ref id="B41"><mixed-citation publication-type="journal"><name><surname>Finzi</surname><given-names>D</given-names></name><name><surname>Blankson</surname><given-names>J</given-names></name><name><surname>Siliciano</surname><given-names>JD</given-names></name><name><surname>Margolick</surname><given-names>JB</given-names></name><name><surname>Chadwick</surname><given-names>K</given-names></name><name><surname>Pierson</surname><given-names>T</given-names></name><name><surname>Smith</surname><given-names>K</given-names></name><name><surname>Lisziewicz</surname><given-names>J</given-names></name><name><surname>Lori</surname><given-names>F</given-names></name><name><surname>Flexner</surname><given-names>C</given-names></name><name><surname>Quinn</surname><given-names>TC</given-names></name><name><surname>Chaisson</surname><given-names>RE</given-names></name><name><surname>Rosenberg</surname><given-names>E</given-names></name><name><surname>Walker</surname><given-names>B</given-names></name><name><surname>Gange</surname><given-names>S</given-names></name><name><surname>Gallant</surname><given-names>J</given-names></name><name><surname>Siliciano</surname><given-names>RF</given-names></name><article-title>Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy</article-title><source>Nat Med</source><year>1999</year><volume>14</volume><fpage>512</fpage><lpage>517</lpage><pub-id pub-id-type="doi">10.1038/8394</pub-id><pub-id pub-id-type="pmid">10229227</pub-id></mixed-citation></ref><ref id="B42"><mixed-citation publication-type="journal"><name><surname>Brooks</surname><given-names>D</given-names></name><name><surname>Kitchen</surname><given-names>S</given-names></name><name><surname>Kitchen</surname><given-names>C</given-names></name><name><surname>Scripture-Adams</surname><given-names>D</given-names></name><name><surname>Zack</surname><given-names>J</given-names></name><article-title>Generation of HIV latency during thymopoiesis</article-title><source>Nature Med</source><year>2001</year><volume>14</volume><fpage>459</fpage><lpage>464</lpage><pub-id pub-id-type="doi">10.1038/86531</pub-id><pub-id pub-id-type="pmid">11283673</pub-id></mixed-citation></ref><ref id="B43"><mixed-citation publication-type="journal"><name><surname>Carter</surname><given-names>CC</given-names></name><name><surname>Onafuwa-Nuga</surname><given-names>A</given-names></name><name><surname>McNamara</surname><given-names>LA</given-names></name><name><surname>Riddell</surname><given-names>Jt</given-names></name><name><surname>Bixby</surname><given-names>D</given-names></name><name><surname>Savona</surname><given-names>MR</given-names></name><name><surname>Collins</surname><given-names>KL</given-names></name><article-title>HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs</article-title><source>Nat Med</source><year>2010</year><volume>14</volume><fpage>446</fpage><lpage>451</lpage><pub-id pub-id-type="doi">10.1038/nm.2109</pub-id><pub-id pub-id-type="pmid">20208541</pub-id></mixed-citation></ref><ref id="B44"><mixed-citation publication-type="other"><name><surname>Wightman</surname><given-names>F</given-names></name><name><surname>Solomon</surname><given-names>A</given-names></name><name><surname>Khoury</surname><given-names>G</given-names></name><name><surname>Green</surname><given-names>J</given-names></name><name><surname>Gray</surname><given-names>L</given-names></name><name><surname>Gorry</surname><given-names>P</given-names></name><name><surname>Ho</surname><given-names>Y</given-names></name><name><surname>Saksena</surname><given-names>N</given-names></name><name><surname>Hoy</surname><given-names>J</given-names></name><name><surname>Crowe</surname><given-names>S</given-names></name><name><surname>Cameron</surname><given-names>P</given-names></name><name><surname>Lewin</surname><given-names>S</given-names></name><article-title>Both CD31-positive and CD31-negative naive CD4 T-cells are persistent HIV-infected reservoirs in individuals receiving antiretroviral therapy</article-title><source>J Infect Dis</source><year>2010</year><comment> in press </comment></mixed-citation></ref><ref id="B45"><mixed-citation publication-type="journal"><name><surname>Sedaghat</surname><given-names>AR</given-names></name><name><surname>Siliciano</surname><given-names>JD</given-names></name><name><surname>Brennan</surname><given-names>TP</given-names></name><name><surname>Wilke</surname><given-names>CO</given-names></name><name><surname>Siliciano</surname><given-names>RF</given-names></name><article-title>Limits on replenishment of the resting CD4+ T cell reservoir for HIV in patients on HAART</article-title><source>PLoS Pathog</source><year>2007</year><volume>14</volume><fpage>e122</fpage><pub-id pub-id-type="doi">10.1371/journal.ppat.0030122</pub-id><pub-id pub-id-type="pmid">17784786</pub-id></mixed-citation></ref><ref id="B46"><mixed-citation publication-type="journal"><name><surname>Brennan</surname><given-names>TP</given-names></name><name><surname>Woods</surname><given-names>JO</given-names></name><name><surname>Sedaghat</surname><given-names>AR</given-names></name><name><surname>Siliciano</surname><given-names>JD</given-names></name><name><surname>Siliciano</surname><given-names>RF</given-names></name><name><surname>Wilke</surname><given-names>CO</given-names></name><article-title>Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapy</article-title><source>J Virol</source><year>2009</year><volume>14</volume><fpage>8470</fpage><lpage>8481</lpage><pub-id pub-id-type="doi">10.1128/JVI.02568-08</pub-id><pub-id pub-id-type="pmid">19535437</pub-id></mixed-citation></ref><ref id="B47"><mixed-citation publication-type="journal"><name><surname>Hermankova</surname><given-names>M</given-names></name><name><surname>Ray</surname><given-names>SC</given-names></name><name><surname>Ruff</surname><given-names>C</given-names></name><name><surname>Powell-Davis</surname><given-names>M</given-names></name><name><surname>Ingersoll</surname><given-names>R</given-names></name><name><surname>D'Aquila</surname><given-names>RT</given-names></name><name><surname>Quinn</surname><given-names>TC</given-names></name><name><surname>Siliciano</surname><given-names>JD</given-names></name><name><surname>Siliciano</surname><given-names>RF</given-names></name><name><surname>Persaud</surname><given-names>D</given-names></name><article-title>HIV-1 drug resistance profiles in children and adults with viral load of <50 copies/ml receiving combination therapy</article-title><source>JAMA</source><year>2001</year><volume>14</volume><fpage>196</fpage><lpage>207</lpage><pub-id pub-id-type="doi">10.1001/jama.286.2.196</pub-id><pub-id pub-id-type="pmid">11448283</pub-id></mixed-citation></ref><ref id="B48"><mixed-citation publication-type="journal"><name><surname>Persaud</surname><given-names>D</given-names></name><name><surname>Siberry</surname><given-names>GK</given-names></name><name><surname>Ahonkhai</surname><given-names>A</given-names></name><name><surname>Kajdas</surname><given-names>J</given-names></name><name><surname>Monie</surname><given-names>D</given-names></name><name><surname>Hutton</surname><given-names>N</given-names></name><name><surname>Watson</surname><given-names>DC</given-names></name><name><surname>Quinn</surname><given-names>TC</given-names></name><name><surname>Ray</surname><given-names>SC</given-names></name><name><surname>Siliciano</surname><given-names>RF</given-names></name><article-title>Continued production of drug-sensitive human immunodeficiency virus type 1 in children on combination antiretroviral therapy who have undetectable viral loads</article-title><source>J Virol</source><year>2004</year><volume>14</volume><fpage>968</fpage><lpage>979</lpage><pub-id pub-id-type="doi">10.1128/JVI.78.2.968-979.2004</pub-id><pub-id pub-id-type="pmid">14694128</pub-id></mixed-citation></ref><ref id="B49"><mixed-citation publication-type="journal"><name><surname>Churchill</surname><given-names>MJ</given-names></name><name><surname>Gorry</surname><given-names>PR</given-names></name><name><surname>Cowley</surname><given-names>D</given-names></name><name><surname>Lal</surname><given-names>L</given-names></name><name><surname>Sonza</surname><given-names>S</given-names></name><name><surname>Purcell</surname><given-names>DF</given-names></name><name><surname>Thompson</surname><given-names>KA</given-names></name><name><surname>Gabuzda</surname><given-names>D</given-names></name><name><surname>McArthur</surname><given-names>JC</given-names></name><name><surname>Pardo</surname><given-names>CA</given-names></name><name><surname>Wesselingh</surname><given-names>SL</given-names></name><article-title>Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues</article-title><source>Journal of Neurovirology</source><year>2006</year><volume>14</volume><fpage>146</fpage><lpage>152</lpage><pub-id pub-id-type="doi">10.1080/13550280600748946</pub-id><pub-id pub-id-type="pmid">16798676</pub-id></mixed-citation></ref><ref id="B50"><mixed-citation publication-type="journal"><name><surname>Chun</surname><given-names>TW</given-names></name><name><surname>Nickle</surname><given-names>DC</given-names></name><name><surname>Justement</surname><given-names>JS</given-names></name><name><surname>Meyers</surname><given-names>JH</given-names></name><name><surname>Roby</surname><given-names>G</given-names></name><name><surname>Hallahan</surname><given-names>CW</given-names></name><name><surname>Kottilil</surname><given-names>S</given-names></name><name><surname>Moir</surname><given-names>S</given-names></name><name><surname>Mican</surname><given-names>JM</given-names></name><name><surname>Mullins</surname><given-names>JI</given-names></name><name><surname>Ward</surname><given-names>DJ</given-names></name><name><surname>Kovacs</surname><given-names>JA</given-names></name><name><surname>Mannon</surname><given-names>PJ</given-names></name><name><surname>Fauci</surname><given-names>AS</given-names></name><article-title>Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy</article-title><source>J Infect Dis</source><year>2008</year><volume>14</volume><fpage>714</fpage><lpage>720</lpage><pub-id pub-id-type="doi">10.1086/527324</pub-id><pub-id pub-id-type="pmid">18260759</pub-id></mixed-citation></ref><ref id="B51"><mixed-citation publication-type="journal"><name><surname>Halfon</surname><given-names>P</given-names></name><name><surname>Giorgetti</surname><given-names>C</given-names></name><name><surname>Khiri</surname><given-names>H</given-names></name><name><surname>Penaranda</surname><given-names>G</given-names></name><name><surname>Terriou</surname><given-names>P</given-names></name><name><surname>Porcu-Buisson</surname><given-names>G</given-names></name><name><surname>Chabert-Orsini</surname><given-names>V</given-names></name><article-title>Semen may harbor HIV despite effective HAART: another piece in the puzzle</article-title><source>Plos One</source><year>2010</year><volume>14</volume><fpage>e10569</fpage><pub-id pub-id-type="doi">10.1371/journal.pone.0010569</pub-id><pub-id pub-id-type="pmid">20485526</pub-id></mixed-citation></ref><ref id="B52"><mixed-citation publication-type="journal"><name><surname>Yukl</surname><given-names>SA</given-names></name><name><surname>Gianella</surname><given-names>S</given-names></name><name><surname>Sinclair</surname><given-names>E</given-names></name><name><surname>Epling</surname><given-names>L</given-names></name><name><surname>Li</surname><given-names>Q</given-names></name><name><surname>Duan</surname><given-names>L</given-names></name><name><surname>Choi</surname><given-names>AL</given-names></name><name><surname>Girling</surname><given-names>V</given-names></name><name><surname>Ho</surname><given-names>T</given-names></name><name><surname>Li</surname><given-names>P</given-names></name><name><surname>Fujimoto</surname><given-names>K</given-names></name><name><surname>Lampiris</surname><given-names>H</given-names></name><name><surname>Hare</surname><given-names>CB</given-names></name><name><surname>Pandori</surname><given-names>M</given-names></name><name><surname>Haase</surname><given-names>AT</given-names></name><name><surname>Günthard</surname><given-names>HF</given-names></name><name><surname>Fischer</surname><given-names>M</given-names></name><name><surname>Shergill</surname><given-names>AK</given-names></name><name><surname>McQuaid</surname><given-names>K</given-names></name><name><surname>Havlir</surname><given-names>DV</given-names></name><name><surname>Wong</surname><given-names>JK</given-names></name><article-title>Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy</article-title><source>J Infect Dis</source><year>2010</year><volume>14</volume><fpage>1553</fpage><lpage>1561</lpage><pub-id pub-id-type="doi">10.1086/656722</pub-id><pub-id pub-id-type="pmid">20939732</pub-id></mixed-citation></ref><ref id="B53"><mixed-citation publication-type="journal"><name><surname>Hutter</surname><given-names>G</given-names></name><name><surname>Nowak</surname><given-names>D</given-names></name><name><surname>Mossner</surname><given-names>M</given-names></name><name><surname>Ganepola</surname><given-names>S</given-names></name><name><surname>Mussig</surname><given-names>A</given-names></name><name><surname>Allers</surname><given-names>K</given-names></name><name><surname>Schneider</surname><given-names>T</given-names></name><name><surname>Hofmann</surname><given-names>J</given-names></name><name><surname>Kucherer</surname><given-names>C</given-names></name><name><surname>Blau</surname><given-names>O</given-names></name><name><surname>Blau</surname><given-names>IW</given-names></name><name><surname>Hofmann</surname><given-names>WK</given-names></name><name><surname>Thiel</surname><given-names>E</given-names></name><article-title>Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation</article-title><source>The New England Journal of Medicine</source><year>2009</year><volume>14</volume><fpage>692</fpage><lpage>698</lpage><pub-id pub-id-type="doi">10.1056/NEJMoa0802905</pub-id><pub-id pub-id-type="pmid">19213682</pub-id></mixed-citation></ref><ref id="B54"><mixed-citation publication-type="journal"><name><surname>Deeks</surname><given-names>SG</given-names></name><name><surname>Walker</surname><given-names>BD</given-names></name><article-title>Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy</article-title><source>Immunity</source><year>2007</year><volume>14</volume><fpage>406</fpage><lpage>416</lpage><pub-id pub-id-type="doi">10.1016/j.immuni.2007.08.010</pub-id><pub-id pub-id-type="pmid">17892849</pub-id></mixed-citation></ref><ref id="B55"><mixed-citation publication-type="journal"><name><surname>Hunt</surname><given-names>PW</given-names></name><name><surname>Brenchley</surname><given-names>J</given-names></name><name><surname>Sinclair</surname><given-names>E</given-names></name><name><surname>McCune</surname><given-names>JM</given-names></name><name><surname>Roland</surname><given-names>M</given-names></name><name><surname>Page-Shafer</surname><given-names>K</given-names></name><name><surname>Hsue</surname><given-names>P</given-names></name><name><surname>Emu</surname><given-names>B</given-names></name><name><surname>Krone</surname><given-names>M</given-names></name><name><surname>Lampiris</surname><given-names>H</given-names></name><name><surname>Douek</surname><given-names>D</given-names></name><name><surname>Martin</surname><given-names>JN</given-names></name><name><surname>Deeks</surname><given-names>SG</given-names></name><article-title>Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy</article-title><source>J Infect Dis</source><year>2008</year><volume>14</volume><fpage>126</fpage><lpage>133</lpage><pub-id pub-id-type="doi">10.1086/524143</pub-id><pub-id pub-id-type="pmid">18171295</pub-id></mixed-citation></ref><ref id="B56"><mixed-citation publication-type="journal"><name><surname>Hatano</surname><given-names>H</given-names></name><name><surname>Delwart</surname><given-names>EL</given-names></name><name><surname>Norris</surname><given-names>PJ</given-names></name><name><surname>Lee</surname><given-names>TH</given-names></name><name><surname>Dunn-Williams</surname><given-names>J</given-names></name><name><surname>Hunt</surname><given-names>PW</given-names></name><name><surname>Hoh</surname><given-names>R</given-names></name><name><surname>Stramer</surname><given-names>SL</given-names></name><name><surname>Linnen</surname><given-names>JM</given-names></name><name><surname>McCune</surname><given-names>JM</given-names></name><name><surname>Martin</surname><given-names>JN</given-names></name><name><surname>Busch</surname><given-names>MP</given-names></name><name><surname>Deeks</surname><given-names>SG</given-names></name><article-title>Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy</article-title><source>J Virol</source><year>2009</year><volume>14</volume><fpage>329</fpage><lpage>335</lpage><pub-id pub-id-type="doi">10.1128/JVI.01763-08</pub-id><pub-id pub-id-type="pmid">18945778</pub-id></mixed-citation></ref><ref id="B57"><mixed-citation publication-type="journal"><name><surname>Pereyra</surname><given-names>F</given-names></name><name><surname>Palmer</surname><given-names>S</given-names></name><name><surname>Miura</surname><given-names>T</given-names></name><name><surname>Block</surname><given-names>BL</given-names></name><name><surname>Wiegand</surname><given-names>A</given-names></name><name><surname>Rothchild</surname><given-names>AC</given-names></name><name><surname>Baker</surname><given-names>B</given-names></name><name><surname>Rosenberg</surname><given-names>R</given-names></name><name><surname>Cutrell</surname><given-names>E</given-names></name><name><surname>Seaman</surname><given-names>MS</given-names></name><name><surname>Coffin</surname><given-names>JM</given-names></name><name><surname>Walker</surname><given-names>BD</given-names></name><article-title>Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters</article-title><source>J Infect Dis</source><year>2009</year><volume>14</volume><fpage>984</fpage><lpage>990</lpage><pub-id pub-id-type="doi">10.1086/605446</pub-id><pub-id pub-id-type="pmid">19656066</pub-id></mixed-citation></ref><ref id="B58"><mixed-citation publication-type="journal"><name><surname>Autran</surname><given-names>B</given-names></name><name><surname>Murphy</surname><given-names>RL</given-names></name><name><surname>Costagliola</surname><given-names>D</given-names></name><name><surname>Tubiana</surname><given-names>R</given-names></name><name><surname>Clotet</surname><given-names>B</given-names></name><name><surname>Gatell</surname><given-names>J</given-names></name><name><surname>Staszewski</surname><given-names>S</given-names></name><name><surname>Wincker</surname><given-names>N</given-names></name><name><surname>Assoumou</surname><given-names>L</given-names></name><name><surname>El-Habib</surname><given-names>R</given-names></name><name><surname>Calvez</surname><given-names>V</given-names></name><name><surname>Walker</surname><given-names>B</given-names></name><name><surname>Katlama</surname><given-names>C</given-names></name><article-title>Greater viral rebound and reduced time to resume antiretroviral therapy after therapeutic immunization with the ALVAC-HIV vaccine (vCP1452)</article-title><source>AIDS</source><year>2008</year><volume>14</volume><fpage>1313</fpage><lpage>1322</lpage><pub-id pub-id-type="doi">10.1097/QAD.0b013e3282fdce94</pub-id><pub-id pub-id-type="pmid">18580611</pub-id></mixed-citation></ref><ref id="B59"><mixed-citation publication-type="journal"><name><surname>O'Connell</surname><given-names>KA</given-names></name><name><surname>Brennan</surname><given-names>TP</given-names></name><name><surname>Bailey</surname><given-names>JR</given-names></name><name><surname>Ray</surname><given-names>SC</given-names></name><name><surname>Siliciano</surname><given-names>RF</given-names></name><name><surname>Blankson</surname><given-names>JN</given-names></name><article-title>Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virus</article-title><source>J Virol</source><year>2010</year><volume>14</volume><fpage>7018</fpage><lpage>7028</lpage><pub-id pub-id-type="pmid">20444904</pub-id></mixed-citation></ref><ref id="B60"><mixed-citation publication-type="journal"><name><surname>Dinoso</surname><given-names>JB</given-names></name><name><surname>Kim</surname><given-names>SY</given-names></name><name><surname>Wiegand</surname><given-names>AM</given-names></name><name><surname>Palmer</surname><given-names>SE</given-names></name><name><surname>Gange</surname><given-names>SJ</given-names></name><name><surname>Cranmer</surname><given-names>L</given-names></name><name><surname>O'Shea</surname><given-names>A</given-names></name><name><surname>Callender</surname><given-names>M</given-names></name><name><surname>Spivak</surname><given-names>A</given-names></name><name><surname>Brennan</surname><given-names>T</given-names></name><name><surname>Kearney</surname><given-names>MF</given-names></name><name><surname>Proschan</surname><given-names>MA</given-names></name><name><surname>Mican</surname><given-names>JM</given-names></name><name><surname>Rehm</surname><given-names>CA</given-names></name><name><surname>Coffin</surname><given-names>JM</given-names></name><name><surname>Mellors</surname><given-names>JW</given-names></name><name><surname>Siliciano</surname><given-names>RF</given-names></name><name><surname>Maldarelli</surname><given-names>F</given-names></name><article-title>Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy</article-title><source>Proc Natl Acad Sci USA</source><year>2009</year><volume>14</volume><fpage>9403</fpage><lpage>9408</lpage><pub-id pub-id-type="doi">10.1073/pnas.0903107106</pub-id><pub-id pub-id-type="pmid">19470482</pub-id></mixed-citation></ref><ref id="B61"><mixed-citation publication-type="journal"><name><surname>McMahon</surname><given-names>D</given-names></name><name><surname>Jones</surname><given-names>J</given-names></name><name><surname>Wiegand</surname><given-names>A</given-names></name><name><surname>Gange</surname><given-names>SJ</given-names></name><name><surname>Kearney</surname><given-names>M</given-names></name><name><surname>Palmer</surname><given-names>S</given-names></name><name><surname>McNulty</surname><given-names>S</given-names></name><name><surname>Metcalf</surname><given-names>JA</given-names></name><name><surname>Acosta</surname><given-names>E</given-names></name><name><surname>Rehm</surname><given-names>C</given-names></name><name><surname>Coffin</surname><given-names>JM</given-names></name><name><surname>Mellors</surname><given-names>JW</given-names></name><name><surname>Maldarelli</surname><given-names>F</given-names></name><article-title>Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy</article-title><source>Clin Infect Dis</source><year>2010</year><volume>14</volume><fpage>912</fpage><lpage>919</lpage><pub-id pub-id-type="doi">10.1086/650749</pub-id><pub-id pub-id-type="pmid">20156060</pub-id></mixed-citation></ref><ref id="B62"><mixed-citation publication-type="journal"><name><surname>Buzon</surname><given-names>JM</given-names></name><name><surname>Massanella</surname><given-names>M</given-names></name><name><surname>Llibre</surname><given-names>JM</given-names></name><name><surname>Esteve</surname><given-names>A</given-names></name><name><surname>Dahl</surname><given-names>V</given-names></name><name><surname>Puertas</surname><given-names>MC</given-names></name><name><surname>Gatell</surname><given-names>JM</given-names></name><name><surname>Domingo</surname><given-names>P</given-names></name><name><surname>Paredes</surname><given-names>R</given-names></name><name><surname>Sharkey</surname><given-names>M</given-names></name><name><surname>Palmer</surname><given-names>S</given-names></name><name><surname>Stevenson</surname><given-names>M</given-names></name><name><surname>Clotet</surname><given-names>B</given-names></name><name><surname>Blanco</surname><given-names>J</given-names></name><name><surname>Martinez-Picado</surname><given-names>J</given-names></name><article-title>HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects</article-title><source>Nat Med</source><year>2010</year><volume>14</volume><fpage>460</fpage><lpage>465</lpage><pub-id pub-id-type="doi">10.1038/nm.2111</pub-id><pub-id pub-id-type="pmid">20228817</pub-id></mixed-citation></ref><ref id="B63"><mixed-citation publication-type="journal"><name><surname>Yukl</surname><given-names>SA</given-names></name><name><surname>Shergill</surname><given-names>AK</given-names></name><name><surname>McQuaid</surname><given-names>K</given-names></name><name><surname>Gianella</surname><given-names>S</given-names></name><name><surname>Lampiris</surname><given-names>H</given-names></name><name><surname>Hare</surname><given-names>CB</given-names></name><name><surname>Pandori</surname><given-names>M</given-names></name><name><surname>Sinclair</surname><given-names>E</given-names></name><name><surname>Gunthard</surname><given-names>HF</given-names></name><name><surname>Fischer</surname><given-names>M</given-names></name><name><surname>Wong</surname><given-names>JK</given-names></name><name><surname>Havlir</surname><given-names>DV</given-names></name><article-title>Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy</article-title><source>AIDS</source><year>2010</year><volume>14</volume><fpage>2451</fpage><lpage>2460</lpage><pub-id pub-id-type="doi">10.1097/QAD.0b013e32833ef7bb</pub-id><pub-id pub-id-type="pmid">20827162</pub-id></mixed-citation></ref><ref id="B64"><mixed-citation publication-type="journal"><name><surname>Yilmaz</surname><given-names>A</given-names></name><name><surname>Verhofstede</surname><given-names>C</given-names></name><name><surname>D'Avolio</surname><given-names>A</given-names></name><name><surname>Watson</surname><given-names>V</given-names></name><name><surname>Hagberg</surname><given-names>L</given-names></name><name><surname>Fuchs</surname><given-names>D</given-names></name><name><surname>Svennerholm</surname><given-names>B</given-names></name><name><surname>Gisslen</surname><given-names>M</given-names></name><article-title>Treatment Intensification Has no Effect on the HIV-1 Central Nervous System Infection in Patients on Suppressive Antiretroviral Therapy</article-title><source>J Acquir Immune Defic Syndr</source><year>2010</year><volume>14</volume><fpage>16</fpage></mixed-citation></ref><ref id="B65"><mixed-citation publication-type="journal"><name><surname>Chun</surname><given-names>TW</given-names></name><name><surname>Justement</surname><given-names>JS</given-names></name><name><surname>Moir</surname><given-names>S</given-names></name><name><surname>Hallahan</surname><given-names>CW</given-names></name><name><surname>Maenza</surname><given-names>J</given-names></name><name><surname>Mullins</surname><given-names>JI</given-names></name><name><surname>Collier</surname><given-names>AC</given-names></name><name><surname>Corey</surname><given-names>L</given-names></name><name><surname>Fauci</surname><given-names>AS</given-names></name><article-title>Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: implications for eradication of virus</article-title><source>J Infect Dis</source><year>2007</year><volume>14</volume><fpage>1762</fpage><lpage>1764</lpage><pub-id pub-id-type="doi">10.1086/518250</pub-id><pub-id pub-id-type="pmid">17492591</pub-id></mixed-citation></ref><ref id="B66"><mixed-citation publication-type="journal"><name><surname>Hocqueloux</surname><given-names>L</given-names></name><name><surname>Prazuck</surname><given-names>T</given-names></name><name><surname>Avettand-Fenoel</surname><given-names>V</given-names></name><name><surname>Lafeuillade</surname><given-names>A</given-names></name><name><surname>Cardon</surname><given-names>B</given-names></name><name><surname>Viard</surname><given-names>JP</given-names></name><name><surname>Rouzioux</surname><given-names>C</given-names></name><article-title>Long-term immunovirologic control following antiretroviral therapy interruption in patients treated at the time of primary HIV-1 infection</article-title><source>AIDS</source><year>2010</year><volume>14</volume><fpage>1598</fpage><lpage>1601</lpage><pub-id pub-id-type="doi">10.1097/QAD.0b013e32833b61ba</pub-id><pub-id pub-id-type="pmid">20549847</pub-id></mixed-citation></ref><ref id="B67"><mixed-citation publication-type="journal"><name><surname>Bloch</surname><given-names>MT</given-names></name><name><surname>Smith</surname><given-names>DE</given-names></name><name><surname>Quan</surname><given-names>D</given-names></name><name><surname>Kaldor</surname><given-names>JM</given-names></name><name><surname>Zaunders</surname><given-names>JJ</given-names></name><name><surname>Petoumenos</surname><given-names>K</given-names></name><name><surname>Irvine</surname><given-names>K</given-names></name><name><surname>Law</surname><given-names>M</given-names></name><name><surname>Grey</surname><given-names>P</given-names></name><name><surname>Finlayson</surname><given-names>RJ</given-names></name><name><surname>McFarlane</surname><given-names>R</given-names></name><name><surname>Kelleher</surname><given-names>AD</given-names></name><name><surname>Carr</surname><given-names>A</given-names></name><name><surname>Cooper</surname><given-names>DA</given-names></name><article-title>The role of hydroxyurea in enhancing the virologic control achieved through structured treatment interruption in primary HIV infection: final results from a randomized clinical trial (Pulse)</article-title><source>J Acquir Immune Defic Syndr</source><year>2006</year><volume>14</volume><fpage>192</fpage><lpage>202</lpage><pub-id pub-id-type="doi">10.1097/01.qai.0000219779.50668.e6</pub-id><pub-id pub-id-type="pmid">16688094</pub-id></mixed-citation></ref><ref id="B68"><mixed-citation publication-type="journal"><name><surname>Markowitz</surname><given-names>M</given-names></name><name><surname>Jin</surname><given-names>X</given-names></name><name><surname>Hurley</surname><given-names>A</given-names></name><name><surname>Simon</surname><given-names>V</given-names></name><name><surname>Ramratnam</surname><given-names>B</given-names></name><name><surname>Louie</surname><given-names>M</given-names></name><name><surname>Deschenes</surname><given-names>GR</given-names></name><name><surname>Ramanathan</surname><given-names>M</given-names><suffix>Jr</suffix></name><name><surname>Barsoum</surname><given-names>S</given-names></name><name><surname>Vanderhoeven</surname><given-names>J</given-names></name><name><surname>He</surname><given-names>T</given-names></name><name><surname>Chung</surname><given-names>C</given-names></name><name><surname>Murray</surname><given-names>J</given-names></name><name><surname>Perelson</surname><given-names>AS</given-names></name><name><surname>Zhang</surname><given-names>L</given-names></name><name><surname>Ho</surname><given-names>DD</given-names></name><article-title>Discontinuation of antiretroviral therapy commenced early during the course of human immunodeficiency virus type 1 infection, with or without adjunctive vaccination</article-title><source>J Infect Dis</source><year>2002</year><volume>14</volume><fpage>634</fpage><lpage>643</lpage><pub-id pub-id-type="doi">10.1086/342559</pub-id><pub-id pub-id-type="pmid">12195350</pub-id></mixed-citation></ref><ref id="B69"><mixed-citation publication-type="journal"><name><surname>Wang</surname><given-names>FX</given-names></name><name><surname>Xu</surname><given-names>Y</given-names></name><name><surname>Sullivan</surname><given-names>J</given-names></name><name><surname>Souder</surname><given-names>E</given-names></name><name><surname>Argyris</surname><given-names>EG</given-names></name><name><surname>Acheampong</surname><given-names>EA</given-names></name><name><surname>Fisher</surname><given-names>J</given-names></name><name><surname>Sierra</surname><given-names>M</given-names></name><name><surname>Thomson</surname><given-names>MM</given-names></name><name><surname>Najera</surname><given-names>R</given-names></name><name><surname>Frank</surname><given-names>I</given-names></name><name><surname>Kulkosky</surname><given-names>J</given-names></name><name><surname>Pomerantz</surname><given-names>RJ</given-names></name><name><surname>Nunnari</surname><given-names>G</given-names></name><article-title>IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART</article-title><source>J Clin Invest</source><year>2005</year><volume>14</volume><fpage>128</fpage><lpage>137</lpage><pub-id pub-id-type="pmid">15630452</pub-id></mixed-citation></ref><ref id="B70"><mixed-citation publication-type="journal"><name><surname>Levy</surname><given-names>Y</given-names></name><name><surname>Lacabaratz</surname><given-names>C</given-names></name><name><surname>Weiss</surname><given-names>L</given-names></name><name><surname>Viard</surname><given-names>JP</given-names></name><name><surname>Goujard</surname><given-names>C</given-names></name><name><surname>Lelievre</surname><given-names>JD</given-names></name><name><surname>Boue</surname><given-names>F</given-names></name><name><surname>Molina</surname><given-names>JM</given-names></name><name><surname>Rouzioux</surname><given-names>C</given-names></name><name><surname>Avettand-Fenoel</surname><given-names>V</given-names></name><name><surname>Croughs</surname><given-names>T</given-names></name><name><surname>Beq</surname><given-names>S</given-names></name><name><surname>Thiebaut</surname><given-names>R</given-names></name><name><surname>Chene</surname><given-names>G</given-names></name><name><surname>Morre</surname><given-names>M</given-names></name><name><surname>Delfraissy</surname><given-names>JF</given-names></name><article-title>Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment</article-title><source>J Clin Invest</source><year>2009</year><volume>14</volume><fpage>997</fpage><lpage>1007</lpage><pub-id pub-id-type="pmid">19287090</pub-id></mixed-citation></ref><ref id="B71"><mixed-citation publication-type="journal"><name><surname>Sereti</surname><given-names>I</given-names></name><name><surname>Dunham</surname><given-names>RM</given-names></name><name><surname>Spritzler</surname><given-names>J</given-names></name><name><surname>Aga</surname><given-names>E</given-names></name><name><surname>Proschan</surname><given-names>MA</given-names></name><name><surname>Medvik</surname><given-names>K</given-names></name><name><surname>Battaglia</surname><given-names>CA</given-names></name><name><surname>Landay</surname><given-names>AL</given-names></name><name><surname>Pahwa</surname><given-names>S</given-names></name><name><surname>Fischl</surname><given-names>MA</given-names></name><name><surname>Asmuth</surname><given-names>DM</given-names></name><name><surname>Tenorio</surname><given-names>AR</given-names></name><name><surname>Altman</surname><given-names>JD</given-names></name><name><surname>Fox</surname><given-names>L</given-names></name><name><surname>Moir</surname><given-names>S</given-names></name><name><surname>Malaspina</surname><given-names>A</given-names></name><name><surname>Morre</surname><given-names>M</given-names></name><name><surname>Buffet</surname><given-names>R</given-names></name><name><surname>Silvestri</surname><given-names>G</given-names></name><name><surname>Lederman</surname><given-names>MM</given-names></name><article-title>IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection</article-title><source>Blood</source><year>2009</year><volume>14</volume><fpage>6304</fpage><lpage>6314</lpage><pub-id pub-id-type="doi">10.1182/blood-2008-10-186601</pub-id><pub-id pub-id-type="pmid">19380868</pub-id></mixed-citation></ref><ref id="B72"><mixed-citation publication-type="journal"><name><surname>Reuse</surname><given-names>S</given-names></name><name><surname>Calao</surname><given-names>M</given-names></name><name><surname>Kabeya</surname><given-names>K</given-names></name><name><surname>Guiguen</surname><given-names>A</given-names></name><name><surname>Gatot</surname><given-names>JS</given-names></name><name><surname>Quivy</surname><given-names>V</given-names></name><name><surname>Vanhulle</surname><given-names>C</given-names></name><name><surname>Lamine</surname><given-names>A</given-names></name><name><surname>Vaira</surname><given-names>D</given-names></name><name><surname>Demonte</surname><given-names>D</given-names></name><name><surname>Martinelli</surname><given-names>V</given-names></name><name><surname>Veithen</surname><given-names>E</given-names></name><name><surname>Cherrier</surname><given-names>T</given-names></name><name><surname>Avettand</surname><given-names>V</given-names></name><name><surname>Poutrel</surname><given-names>S</given-names></name><name><surname>Piette</surname><given-names>J</given-names></name><name><surname>de Launoit</surname><given-names>Y</given-names></name><name><surname>Moutschen</surname><given-names>M</given-names></name><name><surname>Burny</surname><given-names>A</given-names></name><name><surname>Rouzioux</surname><given-names>C</given-names></name><name><surname>De Wit</surname><given-names>S</given-names></name><name><surname>Herbein</surname><given-names>G</given-names></name><name><surname>Rohr</surname><given-names>O</given-names></name><name><surname>Collette</surname><given-names>Y</given-names></name><name><surname>Lambotte</surname><given-names>O</given-names></name><name><surname>Clumeck</surname><given-names>N</given-names></name><name><surname>Van Lint</surname><given-names>C</given-names></name><article-title>Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection</article-title><source>PLoS One</source><year>2009</year><volume>14</volume><fpage>e6093</fpage><pub-id pub-id-type="doi">10.1371/journal.pone.0006093</pub-id><pub-id pub-id-type="pmid">19564922</pub-id></mixed-citation></ref><ref id="B73"><mixed-citation publication-type="journal"><name><surname>Bolden</surname><given-names>J</given-names></name><name><surname>Peart</surname><given-names>M</given-names></name><name><surname>Johnstone</surname><given-names>R</given-names></name><article-title>Anticancer activities of histone deacetylase inhibitors</article-title><source>Nat Rev Drug Discov</source><year>2006</year><volume>14</volume><fpage>769</fpage><lpage>784</lpage><pub-id pub-id-type="doi">10.1038/nrd2133</pub-id><pub-id pub-id-type="pmid">16955068</pub-id></mixed-citation></ref><ref id="B74"><mixed-citation publication-type="journal"><name><surname>Prince</surname><given-names>HM</given-names></name><name><surname>Bishton</surname><given-names>MJ</given-names></name><name><surname>Harrison</surname><given-names>SJ</given-names></name><article-title>Clinical studies of histone deacetylase inhibitors</article-title><source>Clin Cancer Res</source><year>2009</year><volume>14</volume><fpage>3958</fpage><lpage>3969</lpage><pub-id pub-id-type="doi">10.1158/1078-0432.CCR-08-2785</pub-id><pub-id pub-id-type="pmid">19509172</pub-id></mixed-citation></ref><ref id="B75"><mixed-citation publication-type="journal"><name><surname>Lehrman</surname><given-names>G</given-names></name><name><surname>Hogue</surname><given-names>IB</given-names></name><name><surname>Palmer</surname><given-names>S</given-names></name><name><surname>Jennings</surname><given-names>C</given-names></name><name><surname>Spina</surname><given-names>CA</given-names></name><name><surname>Wiegand</surname><given-names>A</given-names></name><name><surname>Landay</surname><given-names>AL</given-names></name><name><surname>Coombs</surname><given-names>RW</given-names></name><name><surname>Richman</surname><given-names>DD</given-names></name><name><surname>Mellors</surname><given-names>JW</given-names></name><name><surname>Coffin</surname><given-names>JM</given-names></name><name><surname>Bosch</surname><given-names>RJ</given-names></name><name><surname>Margolis</surname><given-names>DM</given-names></name><article-title>Depletion of latent HIV-1 infection in vivo: a proof-of-concept study</article-title><source>Lancet</source><year>2005</year><volume>14</volume><fpage>549</fpage><lpage>555</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(05)67098-5</pub-id><pub-id pub-id-type="pmid">16099290</pub-id></mixed-citation></ref><ref id="B76"><mixed-citation publication-type="journal"><name><surname>Archin</surname><given-names>NM</given-names></name><name><surname>Eron</surname><given-names>JJ</given-names></name><name><surname>Palmer</surname><given-names>S</given-names></name><name><surname>Hartmann-Duff</surname><given-names>A</given-names></name><name><surname>Martinson</surname><given-names>JA</given-names></name><name><surname>Wiegand</surname><given-names>A</given-names></name><name><surname>Bandarenko</surname><given-names>N</given-names></name><name><surname>Schmitz</surname><given-names>JL</given-names></name><name><surname>Bosch</surname><given-names>RJ</given-names></name><name><surname>Landay</surname><given-names>AL</given-names></name><name><surname>Coffin</surname><given-names>JM</given-names></name><name><surname>Margolis</surname><given-names>DM</given-names></name><article-title>Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells</article-title><source>AIDS</source><year>2008</year><volume>14</volume><fpage>1131</fpage><lpage>1135</lpage><pub-id pub-id-type="doi">10.1097/QAD.0b013e3282fd6df4</pub-id><pub-id pub-id-type="pmid">18525258</pub-id></mixed-citation></ref><ref id="B77"><mixed-citation publication-type="journal"><name><surname>Siliciano</surname><given-names>JD</given-names></name><name><surname>Lai</surname><given-names>J</given-names></name><name><surname>Callender</surname><given-names>M</given-names></name><name><surname>Pitt</surname><given-names>E</given-names></name><name><surname>Zhang</surname><given-names>H</given-names></name><name><surname>Margolick</surname><given-names>JB</given-names></name><name><surname>Gallant</surname><given-names>JE</given-names></name><name><surname>Cofrancesco</surname><given-names>J</given-names><suffix>Jr</suffix></name><name><surname>Moore</surname><given-names>RD</given-names></name><name><surname>Gange</surname><given-names>SJ</given-names></name><name><surname>Siliciano</surname><given-names>RF</given-names></name><article-title>Stability of the latent reservoir for HIV-1 in patients receiving valproic acid</article-title><source>J Infect Dis</source><year>2007</year><volume>14</volume><fpage>833</fpage><lpage>836</lpage><pub-id pub-id-type="doi">10.1086/511823</pub-id><pub-id pub-id-type="pmid">17299713</pub-id></mixed-citation></ref><ref id="B78"><mixed-citation publication-type="journal"><name><surname>Sagot-Lerolle</surname><given-names>N</given-names></name><name><surname>Lamine</surname><given-names>A</given-names></name><name><surname>Chaix</surname><given-names>ML</given-names></name><name><surname>Boufassa</surname><given-names>F</given-names></name><name><surname>Aboulker</surname><given-names>JP</given-names></name><name><surname>Costagliola</surname><given-names>D</given-names></name><name><surname>Goujard</surname><given-names>C</given-names></name><name><surname>Pallier</surname><given-names>C</given-names></name><name><surname>Delfraissy</surname><given-names>JF</given-names></name><name><surname>Lambotte</surname><given-names>O</given-names></name><article-title>Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir</article-title><source>AIDS</source><year>2008</year><volume>14</volume><fpage>1125</fpage><lpage>1129</lpage><pub-id pub-id-type="doi">10.1097/QAD.0b013e3282fd6ddc</pub-id><pub-id pub-id-type="pmid">18525257</pub-id></mixed-citation></ref><ref id="B79"><mixed-citation publication-type="journal"><name><surname>Contreras</surname><given-names>X</given-names></name><name><surname>Schweneker</surname><given-names>M</given-names></name><name><surname>Chen</surname><given-names>CS</given-names></name><name><surname>McCune</surname><given-names>JM</given-names></name><name><surname>Deeks</surname><given-names>SG</given-names></name><name><surname>Martin</surname><given-names>J</given-names></name><name><surname>Peterlin</surname><given-names>BM</given-names></name><article-title>Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells</article-title><source>The Journal of Biological Chemistry</source><year>2009</year><volume>14</volume><fpage>6782</fpage><lpage>6789</lpage><pub-id pub-id-type="doi">10.1074/jbc.M807898200</pub-id><pub-id pub-id-type="pmid">19136668</pub-id></mixed-citation></ref><ref id="B80"><mixed-citation publication-type="journal"><name><surname>Archin</surname><given-names>NM</given-names></name><name><surname>Espeseth</surname><given-names>A</given-names></name><name><surname>Parker</surname><given-names>D</given-names></name><name><surname>Cheema</surname><given-names>M</given-names></name><name><surname>Hazuda</surname><given-names>D</given-names></name><name><surname>Margolis</surname><given-names>DM</given-names></name><article-title>Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid</article-title><source>AIDS Res Hum Retroviruses</source><year>2009</year><volume>14</volume><fpage>207</fpage><lpage>212</lpage><pub-id pub-id-type="doi">10.1089/aid.2008.0191</pub-id><pub-id pub-id-type="pmid">19239360</pub-id></mixed-citation></ref><ref id="B81"><mixed-citation publication-type="journal"><name><surname>Burnett</surname><given-names>JC</given-names></name><name><surname>Lim</surname><given-names>KI</given-names></name><name><surname>Calafi</surname><given-names>A</given-names></name><name><surname>Rossi</surname><given-names>JJ</given-names></name><name><surname>Schaffer</surname><given-names>DV</given-names></name><name><surname>Arkin</surname><given-names>AP</given-names></name><article-title>Combinatorial latency reactivation for HIV-1 subtypes and variants</article-title><source>J Virol</source><year>2010</year><volume>14</volume><fpage>5958</fpage><lpage>5974</lpage><pub-id pub-id-type="doi">10.1128/JVI.00161-10</pub-id><pub-id pub-id-type="pmid">20357084</pub-id></mixed-citation></ref><ref id="B82"><mixed-citation publication-type="journal"><name><surname>Holt</surname><given-names>N</given-names></name><name><surname>Wang</surname><given-names>J</given-names></name><name><surname>Kim</surname><given-names>K</given-names></name><name><surname>Friedman</surname><given-names>G</given-names></name><name><surname>Wang</surname><given-names>X</given-names></name><name><surname>Taupin</surname><given-names>V</given-names></name><name><surname>Crooks</surname><given-names>GM</given-names></name><name><surname>Kohn</surname><given-names>DB</given-names></name><name><surname>Gregory</surname><given-names>PD</given-names></name><name><surname>Holmes</surname><given-names>MC</given-names></name><name><surname>Cannon</surname><given-names>PM</given-names></name><article-title>Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo</article-title><source>Nat Biotechnol</source><year>2010</year><volume>14</volume><fpage>839</fpage><lpage>847</lpage><pub-id pub-id-type="doi">10.1038/nbt.1663</pub-id><pub-id pub-id-type="pmid">20601939</pub-id></mixed-citation></ref><ref id="B83"><mixed-citation publication-type="journal"><name><surname>DiGiusto</surname><given-names>DL</given-names></name><name><surname>Krishnan</surname><given-names>A</given-names></name><name><surname>Li</surname><given-names>L</given-names></name><name><surname>Li</surname><given-names>H</given-names></name><name><surname>Li</surname><given-names>S</given-names></name><name><surname>Rao</surname><given-names>A</given-names></name><name><surname>Mi</surname><given-names>S</given-names></name><name><surname>Yam</surname><given-names>P</given-names></name><name><surname>Stinson</surname><given-names>S</given-names></name><name><surname>Kalos</surname><given-names>M</given-names></name><name><surname>Alvarnas</surname><given-names>J</given-names></name><name><surname>Lacey</surname><given-names>SF</given-names></name><name><surname>Yee</surname><given-names>JK</given-names></name><name><surname>Li</surname><given-names>M</given-names></name><name><surname>Couture</surname><given-names>L</given-names></name><name><surname>Hsu</surname><given-names>D</given-names></name><name><surname>Forman</surname><given-names>SJ</given-names></name><name><surname>Rossi</surname><given-names>JJ</given-names></name><name><surname>Zaia</surname><given-names>JA</given-names></name><article-title>RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma</article-title><source>Sci Transl Med</source><year>2010</year><volume>14</volume><fpage>36ra43</fpage></mixed-citation></ref><ref id="B84"><mixed-citation publication-type="journal"><name><surname>El-Sadr</surname><given-names>WM</given-names></name><name><surname>Lundgren</surname><given-names>JD</given-names></name><name><surname>Neaton</surname><given-names>JD</given-names></name><name><surname>Gordin</surname><given-names>F</given-names></name><name><surname>Abrams</surname><given-names>D</given-names></name><name><surname>Arduino</surname><given-names>RC</given-names></name><name><surname>Babiker</surname><given-names>A</given-names></name><name><surname>Burman</surname><given-names>W</given-names></name><name><surname>Clumeck</surname><given-names>N</given-names></name><name><surname>Cohen</surname><given-names>CJ</given-names></name><name><surname>Cohn</surname><given-names>D</given-names></name><name><surname>Cooper</surname><given-names>D</given-names></name><name><surname>Darbyshire</surname><given-names>J</given-names></name><name><surname>Emery</surname><given-names>S</given-names></name><name><surname>Fatkenheuer</surname><given-names>G</given-names></name><name><surname>Gazzard</surname><given-names>B</given-names></name><name><surname>Grund</surname><given-names>B</given-names></name><name><surname>Hoy</surname><given-names>J</given-names></name><name><surname>Klingman</surname><given-names>K</given-names></name><name><surname>Losso</surname><given-names>M</given-names></name><name><surname>Markowitz</surname><given-names>N</given-names></name><name><surname>Neuhaus</surname><given-names>J</given-names></name><name><surname>Phillips</surname><given-names>A</given-names></name><name><surname>Rappoport</surname><given-names>C</given-names></name><article-title>CD4+ count-guided interruption of antiretroviral treatment</article-title><source>The New England Journal of Medicine</source><year>2006</year><volume>14</volume><fpage>2283</fpage><lpage>2296</lpage><pub-id pub-id-type="doi">10.1056/NEJMoa062360</pub-id><pub-id pub-id-type="pmid">17135583</pub-id></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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