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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration</title><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="I1">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Victoria 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J" last="Park">Daniel J. Park</name><affiliation><nlm:aff id="I1">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Victoria 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Nguyen Dumont, Tu" sort="Nguyen Dumont, Tu" uniqKey="Nguyen Dumont T" first="Tu" last="Nguyen-Dumont">Tu Nguyen-Dumont</name><affiliation><nlm:aff id="I1">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Victoria 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Campbell, Ian" sort="Campbell, Ian" uniqKey="Campbell I" first="Ian" last="Campbell">Ian Campbell</name><affiliation><nlm:aff id="I2">Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Thompson, Ella" sort="Thompson, Ella" uniqKey="Thompson E" first="Ella" last="Thompson">Ella Thompson</name><affiliation><nlm:aff id="I2">Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Trainer, Alison H" sort="Trainer, Alison H" uniqKey="Trainer A" first="Alison H" last="Trainer">Alison H. Trainer</name><affiliation><nlm:aff id="I3">Familial Cancer Center, The Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Victoria 3010, Australia and Familial Cancer Centre, The Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="I4">The Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Herston, QLD 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="I5">Cancer Genomics Laboratory, Centre Hospitalier de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2</nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="I5">Cancer Genomics Laboratory, Centre Hospitalier de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2</nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="I5">Cancer Genomics Laboratory, Centre Hospitalier de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2</nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="I6">Department of Clinical Genetics, Odense University Hospital, Soenderboulevard 29, 5000 Odense C, Denmark</nlm:aff></affiliation></author><author><name sortKey="J Nson, Lars" sort="J Nson, Lars" uniqKey="J Nson L" first="Lars" last="J Nson">Lars J Nson</name><affiliation><nlm:aff id="I7">Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Inge S" sort="Pedersen, Inge S" uniqKey="Pedersen I" first="Inge S" last="Pedersen">Inge S. Pedersen</name><affiliation><nlm:aff id="I8">Department of Clinical Biochemistry, Section of Molecular Diagnostics, Aalborg University Hospital, Reberbansgade 15, 9000 Aalborg, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas Vo" sort="Hansen, Thomas Vo" uniqKey="Hansen T" first="Thomas Vo" last="Hansen">Thomas Vo Hansen</name><affiliation><nlm:aff id="I7">Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="I9">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki 4th floor PO BOX 700, 00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation><nlm:aff id="I9">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki 4th floor PO BOX 700, 00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga" sort="Sinilnikova, Olga" uniqKey="Sinilnikova O" first="Olga" last="Sinilnikova">Olga Sinilnikova</name><affiliation><nlm:aff id="I10">CNRS UMR5286 INSERM U1052, Université Lyon 1, Cancer Research Center of Lyon, Center Leon Berard, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="I11">Unite Mixte de Genetique Constitutionnelle des Cancers Frequents, Hospices Civils de Lyon, Centre Leon Berard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="I10">CNRS UMR5286 INSERM U1052, Université Lyon 1, Cancer Research Center of Lyon, Center Leon Berard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Lesueur, Fabienne" sort="Lesueur, Fabienne" uniqKey="Lesueur F" first="Fabienne" last="Lesueur">Fabienne Lesueur</name><affiliation><nlm:aff id="I12">INSERM, Unité U900, Mines ParisTech, Equipe Epidémiologie Génétique des Cancers, Institut Curie, 26 rue d'Ulm, 75248 Paris cedex 05, France</nlm:aff></affiliation></author><author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name><affiliation><nlm:aff id="I10">CNRS UMR5286 INSERM U1052, Université Lyon 1, Cancer Research Center of Lyon, Center Leon Berard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita" sort="Schmutzler, Rita" uniqKey="Schmutzler R" first="Rita" last="Schmutzler">Rita Schmutzler</name><affiliation><nlm:aff id="I13">Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="I14">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="I15">Department of Gynaecology and Obstetrics, Klinikum rechts der Isar at the Technical University, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Hahnen, Eric" sort="Hahnen, Eric" uniqKey="Hahnen E" first="Eric" last="Hahnen">Eric Hahnen</name><affiliation><nlm:aff id="I13">Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="I14">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Dufault, Michael R" sort="Dufault, Michael R" uniqKey="Dufault M" first="Michael R" last="Dufault">Michael R. Dufault</name><affiliation><nlm:aff id="I15">Department of Gynaecology and Obstetrics, Klinikum rechts der Isar at the Technical University, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Chris Chan, Tl" sort="Chris Chan, Tl" uniqKey="Chris Chan T" first="Tl" last="Chris Chan">Tl Chris Chan</name><affiliation><nlm:aff id="I16">Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong SAR</nlm:aff></affiliation><affiliation><nlm:aff id="I17">Department of Molecular Pathology, Hong Kong Sanatorium and Hospital, Hong Kong SAR and Departments of Pathology and Surgery, The University of Hong Kong, Hong Kong SAR</nlm:aff></affiliation></author><author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name><affiliation><nlm:aff id="I16">Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong SAR</nlm:aff></affiliation><affiliation><nlm:aff id="I18">Department of Surgery, The University of Hong Kong, Hong Kong SAR; Department of Surgery, Hong Kong Sanatorium and Hospital, Hong Kong SAR; Department of Oncology, Stanford University School of Medicine, Stanford, California, United States of America</nlm:aff></affiliation></author><author><name sortKey="Barkard Ttir, Rosa" sort="Barkard Ttir, Rosa" uniqKey="Barkard Ttir R" first="Rosa" last="Barkard Ttir">Rosa Barkard Ttir</name><affiliation><nlm:aff id="I19">Department of Pathology, Landspitali-University Hospital, Hringbraut, 101, Reykjavik, Iceland and BMC, Faculty of Medicine, University of Iceland, Vatnsmyrarvegi 16, 101, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="I20">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="I21">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="I22">Department of Human Genetics, Leiden University Medical Center, Leiden, 2300 RC Leiden and Department of Pathology, Leiden University Medical Center, Leiden, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hilbers, Florentine" sort="Hilbers, Florentine" uniqKey="Hilbers F" first="Florentine" last="Hilbers">Florentine Hilbers</name><affiliation><nlm:aff id="I22">Department of Human Genetics, Leiden University Medical Center, Leiden, 2300 RC Leiden and Department of Pathology, Leiden University Medical Center, Leiden, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="I23">Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Center (CNIO), E-28029 Madrid, Spain and Spanish Network on Rare Diseases (CIBERER), Valencia 46010, Spain</nlm:aff></affiliation></author><author><name sortKey="Kvist, Anders" sort="Kvist, Anders" uniqKey="Kvist A" first="Anders" last="Kvist">Anders Kvist</name><affiliation><nlm:aff id="I24">Department of Oncology, Clinical Sciences, Lund, University and Skåne University Hospital, Lund 22100, Sweden</nlm:aff></affiliation></author><author><name sortKey="Torngren, Therese" sort="Torngren, Therese" uniqKey="Torngren T" first="Therese" last="Törngren">Therese Törngren</name><affiliation><nlm:aff id="I24">Department of Oncology, Clinical Sciences, Lund, University and Skåne University Hospital, Lund 22100, Sweden</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas" sort="Easton, Douglas" uniqKey="Easton D" first="Douglas" last="Easton">Douglas Easton</name><affiliation><nlm:aff id="I25">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Hunter, David" sort="Hunter, David" uniqKey="Hunter D" first="David" last="Hunter">David Hunter</name><affiliation><nlm:aff id="I26">Harvard School of Public Health, 677 Huntington Avenue, Boston MA, 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation><nlm:aff id="I26">Harvard School of Public Health, 677 Huntington Avenue, Boston MA, 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="I26">Harvard School of Public Health, 677 Huntington Avenue, Boston MA, 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="I27">Division of Epidemiology, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 800, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation><nlm:aff id="I28">Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="I27">Division of Epidemiology, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 800, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Ramus, Susan" sort="Ramus, Susan" uniqKey="Ramus S" first="Susan" last="Ramus">Susan Ramus</name><affiliation><nlm:aff id="I29">Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Feng, Bing Jian" sort="Feng, Bing Jian" uniqKey="Feng B" first="Bing-Jian" last="Feng">Bing-Jian Feng</name><affiliation><nlm:aff id="I30">Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Weitzel, Jeffrey N" sort="Weitzel, Jeffrey N" uniqKey="Weitzel J" first="Jeffrey N" last="Weitzel">Jeffrey N. Weitzel</name><affiliation><nlm:aff id="I31">Division of Clinical Cancer Genetics, City of Hope, 1500 E Duarte Rd, Duarte CA 91010, and the Clinical Cancer Genetics Community Research Network, USA</nlm:aff></affiliation></author><author><name sortKey="Nathanson, Katherine" sort="Nathanson, Katherine" uniqKey="Nathanson K" first="Katherine" last="Nathanson">Katherine Nathanson</name><affiliation><nlm:aff id="I32">Translational Medicine and Human, Genetics and Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="I33">Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA</nlm:aff></affiliation></author><author><name sortKey="Joseph, Vijai" sort="Joseph, Vijai" uniqKey="Joseph V" first="Vijai" last="Joseph">Vijai Joseph</name><affiliation><nlm:aff id="I33">Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA</nlm:aff></affiliation></author><author><name sortKey="Robson, Mark" sort="Robson, Mark" uniqKey="Robson M" first="Mark" last="Robson">Mark Robson</name><affiliation><nlm:aff id="I33">Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA</nlm:aff></affiliation></author><author><name sortKey="Schrader, Kasmintan" sort="Schrader, Kasmintan" uniqKey="Schrader K" first="Kasmintan" last="Schrader">Kasmintan Schrader</name><affiliation><nlm:aff id="I33">Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, San Ming" sort="Wang, San Ming" uniqKey="Wang S" first="San Ming" last="Wang">San Ming Wang</name><affiliation><nlm:aff id="I34">Department of Preventive Medicine, Creighton University School of Medicine, Omaha, NE 68178, USA</nlm:aff></affiliation></author><author><name sortKey="Kim, Yeong C" sort="Kim, Yeong C" uniqKey="Kim Y" first="Yeong C" last="Kim">Yeong C. Kim</name><affiliation><nlm:aff id="I34">Department of Preventive Medicine, Creighton University School of Medicine, Omaha, NE 68178, USA</nlm:aff></affiliation></author><author><name sortKey="Lynch, Henry" sort="Lynch, Henry" uniqKey="Lynch H" first="Henry" last="Lynch">Henry Lynch</name><affiliation><nlm:aff id="I35">Department of Genetics, Cell Biology & Anatomy, College of Medicine University of Nebraska Medical Center, 985145 Nebraska Medical Center, Omaha, NE 68198-5145, USA</nlm:aff></affiliation></author><author><name sortKey="Snyder, Carrie" sort="Snyder, Carrie" uniqKey="Snyder C" first="Carrie" last="Snyder">Carrie Snyder</name><affiliation><nlm:aff id="I35">Department of Genetics, Cell Biology & Anatomy, College of Medicine University of Nebraska Medical Center, 985145 Nebraska Medical Center, Omaha, NE 68198-5145, USA</nlm:aff></affiliation></author><author><name sortKey="Tavtigian, Sean" sort="Tavtigian, Sean" uniqKey="Tavtigian S" first="Sean" last="Tavtigian">Sean Tavtigian</name><affiliation><nlm:aff id="I36">Huntsman Cancer Institute, The University of Utah School of Medicine, Salt Lake City, UT 84112, USA</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan" sort="Neuhausen, Susan" uniqKey="Neuhausen S" first="Susan" last="Neuhausen">Susan Neuhausen</name><affiliation><nlm:aff id="I37">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="I38">Division of Experimental Pathology, Department of Laboratory Medicine. and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E" last="Goldgar">David E. Goldgar</name><affiliation><nlm:aff id="I36">Huntsman Cancer Institute, The University of Utah School of Medicine, Salt Lake City, UT 84112, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23809231</idno><idno type="pmc">3706918</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706918</idno><idno type="RBID">PMC:3706918</idno><idno type="doi">10.1186/bcr3434</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001626</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001626</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration</title><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="I1">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Victoria 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Park, Daniel J" sort="Park, Daniel J" uniqKey="Park D" first="Daniel J" last="Park">Daniel J. Park</name><affiliation><nlm:aff id="I1">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Victoria 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Nguyen Dumont, Tu" sort="Nguyen Dumont, Tu" uniqKey="Nguyen Dumont T" first="Tu" last="Nguyen-Dumont">Tu Nguyen-Dumont</name><affiliation><nlm:aff id="I1">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Victoria 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Campbell, Ian" sort="Campbell, Ian" uniqKey="Campbell I" first="Ian" last="Campbell">Ian Campbell</name><affiliation><nlm:aff id="I2">Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Thompson, Ella" sort="Thompson, Ella" uniqKey="Thompson E" first="Ella" last="Thompson">Ella Thompson</name><affiliation><nlm:aff id="I2">Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Trainer, Alison H" sort="Trainer, Alison H" uniqKey="Trainer A" first="Alison H" last="Trainer">Alison H. Trainer</name><affiliation><nlm:aff id="I3">Familial Cancer Center, The Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Victoria 3010, Australia and Familial Cancer Centre, The Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="I4">The Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Herston, QLD 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="I5">Cancer Genomics Laboratory, Centre Hospitalier de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2</nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="I5">Cancer Genomics Laboratory, Centre Hospitalier de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2</nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="I5">Cancer Genomics Laboratory, Centre Hospitalier de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2</nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="I6">Department of Clinical Genetics, Odense University Hospital, Soenderboulevard 29, 5000 Odense C, Denmark</nlm:aff></affiliation></author><author><name sortKey="J Nson, Lars" sort="J Nson, Lars" uniqKey="J Nson L" first="Lars" last="J Nson">Lars J Nson</name><affiliation><nlm:aff id="I7">Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Inge S" sort="Pedersen, Inge S" uniqKey="Pedersen I" first="Inge S" last="Pedersen">Inge S. Pedersen</name><affiliation><nlm:aff id="I8">Department of Clinical Biochemistry, Section of Molecular Diagnostics, Aalborg University Hospital, Reberbansgade 15, 9000 Aalborg, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas Vo" sort="Hansen, Thomas Vo" uniqKey="Hansen T" first="Thomas Vo" last="Hansen">Thomas Vo Hansen</name><affiliation><nlm:aff id="I7">Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="I9">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki 4th floor PO BOX 700, 00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation><nlm:aff id="I9">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki 4th floor PO BOX 700, 00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga" sort="Sinilnikova, Olga" uniqKey="Sinilnikova O" first="Olga" last="Sinilnikova">Olga Sinilnikova</name><affiliation><nlm:aff id="I10">CNRS UMR5286 INSERM U1052, Université Lyon 1, Cancer Research Center of Lyon, Center Leon Berard, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="I11">Unite Mixte de Genetique Constitutionnelle des Cancers Frequents, Hospices Civils de Lyon, Centre Leon Berard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="I10">CNRS UMR5286 INSERM U1052, Université Lyon 1, Cancer Research Center of Lyon, Center Leon Berard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Lesueur, Fabienne" sort="Lesueur, Fabienne" uniqKey="Lesueur F" first="Fabienne" last="Lesueur">Fabienne Lesueur</name><affiliation><nlm:aff id="I12">INSERM, Unité U900, Mines ParisTech, Equipe Epidémiologie Génétique des Cancers, Institut Curie, 26 rue d'Ulm, 75248 Paris cedex 05, France</nlm:aff></affiliation></author><author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name><affiliation><nlm:aff id="I10">CNRS UMR5286 INSERM U1052, Université Lyon 1, Cancer Research Center of Lyon, Center Leon Berard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita" sort="Schmutzler, Rita" uniqKey="Schmutzler R" first="Rita" last="Schmutzler">Rita Schmutzler</name><affiliation><nlm:aff id="I13">Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="I14">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="I15">Department of Gynaecology and Obstetrics, Klinikum rechts der Isar at the Technical University, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Hahnen, Eric" sort="Hahnen, Eric" uniqKey="Hahnen E" first="Eric" last="Hahnen">Eric Hahnen</name><affiliation><nlm:aff id="I13">Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="I14">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Dufault, Michael R" sort="Dufault, Michael R" uniqKey="Dufault M" first="Michael R" last="Dufault">Michael R. Dufault</name><affiliation><nlm:aff id="I15">Department of Gynaecology and Obstetrics, Klinikum rechts der Isar at the Technical University, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Chris Chan, Tl" sort="Chris Chan, Tl" uniqKey="Chris Chan T" first="Tl" last="Chris Chan">Tl Chris Chan</name><affiliation><nlm:aff id="I16">Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong SAR</nlm:aff></affiliation><affiliation><nlm:aff id="I17">Department of Molecular Pathology, Hong Kong Sanatorium and Hospital, Hong Kong SAR and Departments of Pathology and Surgery, The University of Hong Kong, Hong Kong SAR</nlm:aff></affiliation></author><author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name><affiliation><nlm:aff id="I16">Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong SAR</nlm:aff></affiliation><affiliation><nlm:aff id="I18">Department of Surgery, The University of Hong Kong, Hong Kong SAR; Department of Surgery, Hong Kong Sanatorium and Hospital, Hong Kong SAR; Department of Oncology, Stanford University School of Medicine, Stanford, California, United States of America</nlm:aff></affiliation></author><author><name sortKey="Barkard Ttir, Rosa" sort="Barkard Ttir, Rosa" uniqKey="Barkard Ttir R" first="Rosa" last="Barkard Ttir">Rosa Barkard Ttir</name><affiliation><nlm:aff id="I19">Department of Pathology, Landspitali-University Hospital, Hringbraut, 101, Reykjavik, Iceland and BMC, Faculty of Medicine, University of Iceland, Vatnsmyrarvegi 16, 101, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="I20">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="I21">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="I22">Department of Human Genetics, Leiden University Medical Center, Leiden, 2300 RC Leiden and Department of Pathology, Leiden University Medical Center, Leiden, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hilbers, Florentine" sort="Hilbers, Florentine" uniqKey="Hilbers F" first="Florentine" last="Hilbers">Florentine Hilbers</name><affiliation><nlm:aff id="I22">Department of Human Genetics, Leiden University Medical Center, Leiden, 2300 RC Leiden and Department of Pathology, Leiden University Medical Center, Leiden, 2300 RC Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="I23">Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Center (CNIO), E-28029 Madrid, Spain and Spanish Network on Rare Diseases (CIBERER), Valencia 46010, Spain</nlm:aff></affiliation></author><author><name sortKey="Kvist, Anders" sort="Kvist, Anders" uniqKey="Kvist A" first="Anders" last="Kvist">Anders Kvist</name><affiliation><nlm:aff id="I24">Department of Oncology, Clinical Sciences, Lund, University and Skåne University Hospital, Lund 22100, Sweden</nlm:aff></affiliation></author><author><name sortKey="Torngren, Therese" sort="Torngren, Therese" uniqKey="Torngren T" first="Therese" last="Törngren">Therese Törngren</name><affiliation><nlm:aff id="I24">Department of Oncology, Clinical Sciences, Lund, University and Skåne University Hospital, Lund 22100, Sweden</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas" sort="Easton, Douglas" uniqKey="Easton D" first="Douglas" last="Easton">Douglas Easton</name><affiliation><nlm:aff id="I25">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Hunter, David" sort="Hunter, David" uniqKey="Hunter D" first="David" last="Hunter">David Hunter</name><affiliation><nlm:aff id="I26">Harvard School of Public Health, 677 Huntington Avenue, Boston MA, 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation><nlm:aff id="I26">Harvard School of Public Health, 677 Huntington Avenue, Boston MA, 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="I26">Harvard School of Public Health, 677 Huntington Avenue, Boston MA, 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="I27">Division of Epidemiology, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 800, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name><affiliation><nlm:aff id="I28">Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="I27">Division of Epidemiology, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 800, Nashville, TN 37203, USA</nlm:aff></affiliation></author><author><name sortKey="Ramus, Susan" sort="Ramus, Susan" uniqKey="Ramus S" first="Susan" last="Ramus">Susan Ramus</name><affiliation><nlm:aff id="I29">Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Feng, Bing Jian" sort="Feng, Bing Jian" uniqKey="Feng B" first="Bing-Jian" last="Feng">Bing-Jian Feng</name><affiliation><nlm:aff id="I30">Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Weitzel, Jeffrey N" sort="Weitzel, Jeffrey N" uniqKey="Weitzel J" first="Jeffrey N" last="Weitzel">Jeffrey N. Weitzel</name><affiliation><nlm:aff id="I31">Division of Clinical Cancer Genetics, City of Hope, 1500 E Duarte Rd, Duarte CA 91010, and the Clinical Cancer Genetics Community Research Network, USA</nlm:aff></affiliation></author><author><name sortKey="Nathanson, Katherine" sort="Nathanson, Katherine" uniqKey="Nathanson K" first="Katherine" last="Nathanson">Katherine Nathanson</name><affiliation><nlm:aff id="I32">Translational Medicine and Human, Genetics and Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="I33">Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA</nlm:aff></affiliation></author><author><name sortKey="Joseph, Vijai" sort="Joseph, Vijai" uniqKey="Joseph V" first="Vijai" last="Joseph">Vijai Joseph</name><affiliation><nlm:aff id="I33">Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA</nlm:aff></affiliation></author><author><name sortKey="Robson, Mark" sort="Robson, Mark" uniqKey="Robson M" first="Mark" last="Robson">Mark Robson</name><affiliation><nlm:aff id="I33">Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA</nlm:aff></affiliation></author><author><name sortKey="Schrader, Kasmintan" sort="Schrader, Kasmintan" uniqKey="Schrader K" first="Kasmintan" last="Schrader">Kasmintan Schrader</name><affiliation><nlm:aff id="I33">Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, San Ming" sort="Wang, San Ming" uniqKey="Wang S" first="San Ming" last="Wang">San Ming Wang</name><affiliation><nlm:aff id="I34">Department of Preventive Medicine, Creighton University School of Medicine, Omaha, NE 68178, USA</nlm:aff></affiliation></author><author><name sortKey="Kim, Yeong C" sort="Kim, Yeong C" uniqKey="Kim Y" first="Yeong C" last="Kim">Yeong C. Kim</name><affiliation><nlm:aff id="I34">Department of Preventive Medicine, Creighton University School of Medicine, Omaha, NE 68178, USA</nlm:aff></affiliation></author><author><name sortKey="Lynch, Henry" sort="Lynch, Henry" uniqKey="Lynch H" first="Henry" last="Lynch">Henry Lynch</name><affiliation><nlm:aff id="I35">Department of Genetics, Cell Biology & Anatomy, College of Medicine University of Nebraska Medical Center, 985145 Nebraska Medical Center, Omaha, NE 68198-5145, USA</nlm:aff></affiliation></author><author><name sortKey="Snyder, Carrie" sort="Snyder, Carrie" uniqKey="Snyder C" first="Carrie" last="Snyder">Carrie Snyder</name><affiliation><nlm:aff id="I35">Department of Genetics, Cell Biology & Anatomy, College of Medicine University of Nebraska Medical Center, 985145 Nebraska Medical Center, Omaha, NE 68198-5145, USA</nlm:aff></affiliation></author><author><name sortKey="Tavtigian, Sean" sort="Tavtigian, Sean" uniqKey="Tavtigian S" first="Sean" last="Tavtigian">Sean Tavtigian</name><affiliation><nlm:aff id="I36">Huntsman Cancer Institute, The University of Utah School of Medicine, Salt Lake City, UT 84112, USA</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan" sort="Neuhausen, Susan" uniqKey="Neuhausen S" first="Susan" last="Neuhausen">Susan Neuhausen</name><affiliation><nlm:aff id="I37">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="I38">Division of Experimental Pathology, Department of Laboratory Medicine. and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E" last="Goldgar">David E. Goldgar</name><affiliation><nlm:aff id="I36">Huntsman Cancer Institute, The University of Utah School of Medicine, Salt Lake City, UT 84112, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Breast Cancer Research : BCR</title><idno type="ISSN">1465-5411</idno><idno type="eISSN">1465-542X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Thompson, Er" uniqKey="Thompson E">ER Thompson</name></author><author><name sortKey="Doyle, Ma" uniqKey="Doyle M">MA Doyle</name></author><author><name sortKey="Ryland, Gl" uniqKey="Ryland G">GL Ryland</name></author><author><name sortKey="Rowley, Sm" uniqKey="Rowley S">SM Rowley</name></author><author><name sortKey="Choong, Dy" uniqKey="Choong D">DY Choong</name></author><author><name sortKey="Tothill, Rw" uniqKey="Tothill R">RW Tothill</name></author><author><name sortKey="Thorne, H" uniqKey="Thorne H">H Thorne</name></author><author><name sortKey="Barnes, Dr" uniqKey="Barnes D">DR Barnes</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Ellul, J" uniqKey="Ellul J">J Ellul</name></author><author><name sortKey="Philip, Gk" uniqKey="Philip G">GK Philip</name></author><author><name sortKey="Antill, Yc" uniqKey="Antill Y">YC Antill</name></author><author><name sortKey="James, Pa" uniqKey="James P">PA James</name></author><author><name sortKey="Trainer, Ah" uniqKey="Trainer A">AH Trainer</name></author><author><name sortKey="Mitchell, G" uniqKey="Mitchell G">G Mitchell</name></author><author><name sortKey="Campbell, Ig" uniqKey="Campbell I">IG Campbell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Dj" uniqKey="Park D">DJ Park</name></author><author><name sortKey="Lesueur, F" uniqKey="Lesueur F">F Lesueur</name></author><author><name sortKey="Nguyen Dumont, T" uniqKey="Nguyen Dumont T">T Nguyen-Dumont</name></author><author><name sortKey="Pertesi, M" uniqKey="Pertesi M">M Pertesi</name></author><author><name sortKey="Odefrey, F" uniqKey="Odefrey F">F Odefrey</name></author><author><name sortKey="Hammet, F" uniqKey="Hammet F">F Hammet</name></author><author><name sortKey="Neuhausen, Sl" uniqKey="Neuhausen S">SL Neuhausen</name></author><author><name sortKey="John, Em" uniqKey="John E">EM John</name></author><author><name sortKey="Andrulis, Il" uniqKey="Andrulis I">IL Andrulis</name></author><author><name sortKey="Terry, Mb" uniqKey="Terry M">MB Terry</name></author><author><name sortKey="Daly, M" uniqKey="Daly M">M Daly</name></author><author><name sortKey="Buys, S" uniqKey="Buys S">S Buys</name></author><author><name sortKey="Le Calvez Kelm, F" uniqKey="Le Calvez Kelm F">F Le Calvez-Kelm</name></author><author><name sortKey="Lonie, A" uniqKey="Lonie A">A Lonie</name></author><author><name sortKey="Pope, Bj" uniqKey="Pope B">BJ Pope</name></author><author><name sortKey="Tsimiklis, H" uniqKey="Tsimiklis H">H Tsimiklis</name></author><author><name sortKey="Voegele, C" uniqKey="Voegele C">C Voegele</name></author><author><name sortKey="Hilbers, Fm" uniqKey="Hilbers F">FM Hilbers</name></author><author><name sortKey="Hoogerbrugge, N" uniqKey="Hoogerbrugge N">N Hoogerbrugge</name></author><author><name sortKey="Barroso, A" uniqKey="Barroso A">A Barroso</name></author><author><name sortKey="Osorio, A" uniqKey="Osorio A">A Osorio</name></author><author><name sortKey="Giles, Gg" uniqKey="Giles G">GG Giles</name></author><author><name sortKey="Devilee, P" uniqKey="Devilee P">P Devilee</name></author><author><name sortKey="Benitez, J" uniqKey="Benitez J">J Benitez</name></author><author><name sortKey="Hopper, Jl" uniqKey="Hopper J">JL Hopper</name></author><author><name sortKey="Tavtigian, Sv" uniqKey="Tavtigian S">SV Tavtigian</name></author><author><name sortKey="Goldgar, De" uniqKey="Goldgar D">DE Goldgar</name></author><author><name sortKey="Southey, Mc" uniqKey="Southey M">MC Southey</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article" xml:lang="en"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Breast Cancer Res</journal-id><journal-id journal-id-type="iso-abbrev">Breast Cancer Res</journal-id><journal-title-group><journal-title>Breast Cancer Research : BCR</journal-title></journal-title-group><issn pub-type="ppub">1465-5411</issn><issn pub-type="epub">1465-542X</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23809231</article-id><article-id pub-id-type="pmc">3706918</article-id><article-id pub-id-type="publisher-id">bcr3434</article-id><article-id pub-id-type="doi">10.1186/bcr3434</article-id><article-categories><subj-group subj-group-type="heading"><subject>Letter</subject></subj-group></article-categories><title-group><article-title>COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration</article-title></title-group><contrib-group><contrib contrib-type="author" id="A1"><collab>COMPLEXO</collab><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" corresp="yes" id="A2"><name><surname>Southey</surname><given-names>Melissa C</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A3"><name><surname>Park</surname><given-names>Daniel J</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A4"><name><surname>Nguyen-Dumont</surname><given-names>Tu</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A5"><name><surname>Campbell</surname><given-names>Ian</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A6"><name><surname>Thompson</surname><given-names>Ella</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A7"><name><surname>Trainer</surname><given-names>Alison H</given-names></name><xref ref-type="aff" rid="I3">3</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A8"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="I4">4</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A9"><name><surname>Simard</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="I5">5</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A10"><name><surname>Dumont</surname><given-names>Martine</given-names></name><xref ref-type="aff" rid="I5">5</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A11"><name><surname>Soucy</surname><given-names>Penny</given-names></name><xref ref-type="aff" rid="I5">5</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A12"><name><surname>Thomassen</surname><given-names>Mads</given-names></name><xref ref-type="aff" rid="I6">6</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A13"><name><surname>Jønson</surname><given-names>Lars</given-names></name><xref ref-type="aff" rid="I7">7</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A14"><name><surname>Pedersen</surname><given-names>Inge S</given-names></name><xref ref-type="aff" rid="I8">8</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A15"><name><surname>Hansen</surname><given-names>Thomas VO</given-names></name><xref ref-type="aff" rid="I7">7</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A16"><name><surname>Nevanlinna</surname><given-names>Heli</given-names></name><xref ref-type="aff" rid="I9">9</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A17"><name><surname>Khan</surname><given-names>Sofia</given-names></name><xref ref-type="aff" rid="I9">9</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A18"><name><surname>Sinilnikova</surname><given-names>Olga</given-names></name><xref ref-type="aff" rid="I10">10</xref><xref ref-type="aff" rid="I11">11</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A19"><name><surname>Mazoyer</surname><given-names>Sylvie</given-names></name><xref ref-type="aff" rid="I10">10</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A20"><name><surname>Lesueur</surname><given-names>Fabienne</given-names></name><xref ref-type="aff" rid="I12">12</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A21"><name><surname>Damiola</surname><given-names>Francesca</given-names></name><xref ref-type="aff" rid="I10">10</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A22"><name><surname>Schmutzler</surname><given-names>Rita</given-names></name><xref ref-type="aff" rid="I13">13</xref><xref ref-type="aff" rid="I14">14</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A23"><name><surname>Meindl</surname><given-names>Alfons</given-names></name><xref ref-type="aff" rid="I15">15</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A24"><name><surname>Hahnen</surname><given-names>Eric</given-names></name><xref ref-type="aff" rid="I13">13</xref><xref ref-type="aff" rid="I14">14</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A25"><name><surname>Dufault</surname><given-names>Michael R</given-names></name><xref ref-type="aff" rid="I15">15</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A26"><name><surname>Chris Chan</surname><given-names>TL</given-names></name><xref ref-type="aff" rid="I16">16</xref><xref ref-type="aff" rid="I17">17</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A27"><name><surname>Kwong</surname><given-names>Ava</given-names></name><xref ref-type="aff" rid="I16">16</xref><xref ref-type="aff" rid="I18">18</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A28"><name><surname>Barkardóttir</surname><given-names>Rosa</given-names></name><xref ref-type="aff" rid="I19">19</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A29"><name><surname>Radice</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="I20">20</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A30"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="I21">21</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A31"><name><surname>Devilee</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="I22">22</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A32"><name><surname>Hilbers</surname><given-names>Florentine</given-names></name><xref ref-type="aff" rid="I22">22</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A33"><name><surname>Benitez</surname><given-names>Javier</given-names></name><xref ref-type="aff" rid="I23">23</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A34"><name><surname>Kvist</surname><given-names>Anders</given-names></name><xref ref-type="aff" rid="I24">24</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A35"><name><surname>Törngren</surname><given-names>Therese</given-names></name><xref ref-type="aff" rid="I24">24</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A36"><name><surname>Easton</surname><given-names>Douglas</given-names></name><xref ref-type="aff" rid="I25">25</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A37"><name><surname>Hunter</surname><given-names>David</given-names></name><xref ref-type="aff" rid="I26">26</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A38"><name><surname>Lindstrom</surname><given-names>Sara</given-names></name><xref ref-type="aff" rid="I26">26</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A39"><name><surname>Kraft</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="I26">26</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A40"><name><surname>Zheng</surname><given-names>Wei</given-names></name><xref ref-type="aff" rid="I27">27</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A41"><name><surname>Gao</surname><given-names>Yu-Tang</given-names></name><xref ref-type="aff" rid="I28">28</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A42"><name><surname>Long</surname><given-names>Jirong</given-names></name><xref ref-type="aff" rid="I27">27</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A43"><name><surname>Ramus</surname><given-names>Susan</given-names></name><xref ref-type="aff" rid="I29">29</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A44"><name><surname>Feng</surname><given-names>Bing-Jian</given-names></name><xref ref-type="aff" rid="I30">30</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A45"><name><surname>Weitzel</surname><given-names>Jeffrey N</given-names></name><xref ref-type="aff" rid="I31">31</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A46"><name><surname>Nathanson</surname><given-names>Katherine</given-names></name><xref ref-type="aff" rid="I32">32</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A47"><name><surname>Offit</surname><given-names>Kenneth</given-names></name><xref ref-type="aff" rid="I33">33</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A48"><name><surname>Joseph</surname><given-names>Vijai</given-names></name><xref ref-type="aff" rid="I33">33</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A49"><name><surname>Robson</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="I33">33</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A50"><name><surname>Schrader</surname><given-names>Kasmintan</given-names></name><xref ref-type="aff" rid="I33">33</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A51"><name><surname>Wang</surname><given-names>San Ming</given-names></name><xref ref-type="aff" rid="I34">34</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A52"><name><surname>Kim</surname><given-names>Yeong C</given-names></name><xref ref-type="aff" rid="I34">34</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A53"><name><surname>Lynch</surname><given-names>Henry</given-names></name><xref ref-type="aff" rid="I35">35</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A54"><name><surname>Snyder</surname><given-names>Carrie</given-names></name><xref ref-type="aff" rid="I35">35</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A55"><name><surname>Tavtigian</surname><given-names>Sean</given-names></name><xref ref-type="aff" rid="I36">36</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A56"><name><surname>Neuhausen</surname><given-names>Susan</given-names></name><xref ref-type="aff" rid="I37">37</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A57"><name><surname>Couch</surname><given-names>Fergus J</given-names></name><xref ref-type="aff" rid="I38">38</xref><email>msouthey@unimelb.edu.au</email></contrib><contrib contrib-type="author" id="A58"><name><surname>Goldgar</surname><given-names>David E</given-names></name><xref ref-type="aff" rid="I36">36</xref><email>msouthey@unimelb.edu.au</email></contrib></contrib-group><aff id="I1"><label>1</label>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Victoria 3010, Australia</aff><aff id="I2"><label>2</label>Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria, Australia</aff><aff id="I3"><label>3</label>Familial Cancer Center, The Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Victoria 3010, Australia and Familial Cancer Centre, The Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia</aff><aff id="I4"><label>4</label>The Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Herston, QLD 4029, Australia</aff><aff id="I5"><label>5</label>Cancer Genomics Laboratory, Centre Hospitalier de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2</aff><aff id="I6"><label>6</label>Department of Clinical Genetics, Odense University Hospital, Soenderboulevard 29, 5000 Odense C, Denmark</aff><aff id="I7"><label>7</label>Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</aff><aff id="I8"><label>8</label>Department of Clinical Biochemistry, Section of Molecular Diagnostics, Aalborg University Hospital, Reberbansgade 15, 9000 Aalborg, Denmark</aff><aff id="I9"><label>9</label>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki 4th floor PO BOX 700, 00029 HUS, Finland</aff><aff id="I10"><label>10</label>CNRS UMR5286 INSERM U1052, Université Lyon 1, Cancer Research Center of Lyon, Center Leon Berard, Lyon, France</aff><aff id="I11"><label>11</label>Unite Mixte de Genetique Constitutionnelle des Cancers Frequents, Hospices Civils de Lyon, Centre Leon Berard, Lyon, France</aff><aff id="I12"><label>12</label>INSERM, Unité U900, Mines ParisTech, Equipe Epidémiologie Génétique des Cancers, Institut Curie, 26 rue d'Ulm, 75248 Paris cedex 05, France</aff><aff id="I13"><label>13</label>Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</aff><aff id="I14"><label>14</label>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany</aff><aff id="I15"><label>15</label>Department of Gynaecology and Obstetrics, Klinikum rechts der Isar at the Technical University, Munich, Germany</aff><aff id="I16"><label>16</label>Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong SAR</aff><aff id="I17"><label>17</label>Department of Molecular Pathology, Hong Kong Sanatorium and Hospital, Hong Kong SAR and Departments of Pathology and Surgery, The University of Hong Kong, Hong Kong SAR</aff><aff id="I18"><label>18</label>Department of Surgery, The University of Hong Kong, Hong Kong SAR; Department of Surgery, Hong Kong Sanatorium and Hospital, Hong Kong SAR; Department of Oncology, Stanford University School of Medicine, Stanford, California, United States of America</aff><aff id="I19"><label>19</label>Department of Pathology, Landspitali-University Hospital, Hringbraut, 101, Reykjavik, Iceland and BMC, Faculty of Medicine, University of Iceland, Vatnsmyrarvegi 16, 101, Reykjavik, Iceland</aff><aff id="I20"><label>20</label>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</aff><aff id="I21"><label>21</label>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</aff><aff id="I22"><label>22</label>Department of Human Genetics, Leiden University Medical Center, Leiden, 2300 RC Leiden and Department of Pathology, Leiden University Medical Center, Leiden, 2300 RC Leiden, The Netherlands</aff><aff id="I23"><label>23</label>Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Center (CNIO), E-28029 Madrid, Spain and Spanish Network on Rare Diseases (CIBERER), Valencia 46010, Spain</aff><aff id="I24"><label>24</label>Department of Oncology, Clinical Sciences, Lund, University and Skåne University Hospital, Lund 22100, Sweden</aff><aff id="I25"><label>25</label>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK</aff><aff id="I26"><label>26</label>Harvard School of Public Health, 677 Huntington Avenue, Boston MA, 02115, USA</aff><aff id="I27"><label>27</label>Division of Epidemiology, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 800, Nashville, TN 37203, USA</aff><aff id="I28"><label>28</label>Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China</aff><aff id="I29"><label>29</label>Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA</aff><aff id="I30"><label>30</label>Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA</aff><aff id="I31"><label>31</label>Division of Clinical Cancer Genetics, City of Hope, 1500 E Duarte Rd, Duarte CA 91010, and the Clinical Cancer Genetics Community Research Network, USA</aff><aff id="I32"><label>32</label>Translational Medicine and Human, Genetics and Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA</aff><aff id="I33"><label>33</label>Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA</aff><aff id="I34"><label>34</label>Department of Preventive Medicine, Creighton University School of Medicine, Omaha, NE 68178, USA</aff><aff id="I35"><label>35</label>Department of Genetics, Cell Biology & Anatomy, College of Medicine University of Nebraska Medical Center, 985145 Nebraska Medical Center, Omaha, NE 68198-5145, USA</aff><aff id="I36"><label>36</label>Huntsman Cancer Institute, The University of Utah School of Medicine, Salt Lake City, UT 84112, USA</aff><aff id="I37"><label>37</label>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA</aff><aff id="I38"><label>38</label>Division of Experimental Pathology, Department of Laboratory Medicine. and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA</aff><pub-date pub-type="ppub"><year>2013</year></pub-date><pub-date pub-type="epub"><day>21</day><month>6</month><year>2013</year></pub-date><pmc-comment> PMC Release delay is 6 months and 0 days and was based on the epub date.</pmc-comment>
<pub-date pub-type="pmc-release"><day>21</day><month>12</month><year>2013</year></pub-date><volume>15</volume><issue>3</issue><fpage>402</fpage><lpage>402</lpage><permissions><copyright-statement>Copyright © 2013 BioMed Central Ltd</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>BioMed Central Ltd</copyright-holder></permissions><self-uri xlink:href="http://breast-cancer-research.com/content/15/3/402"></self-uri></article-meta></front><body><sec><title></title><p>Linkage analysis, positional cloning, candidate gene mutation scanning and genome-wide association study approaches have all contributed significantly to our understanding of the underlying genetic architecture of breast cancer. Taken together, these approaches have identified genetic variation that explains approximately 30% of the overall familial risk of breast cancer, implying that more, and likely rarer, genetic susceptibility alleles remain to be discovered.</p><p>The application of massively parallel sequencing has further demonstrated the complexity of human genetic variation and has raised many challenges for computational and statistical methods for searching for additional breast cancer predisposition genes. Early findings are consistent with previous indications that no single gene is likely to account for a large proportion of the remaining unexplained genetic susceptibility [<xref ref-type="bibr" rid="B1">1</xref>,<xref ref-type="bibr" rid="B2">2</xref>].</p><p>Coordinated international collaboration offers great potential to advance the discovery of additional breast cancer susceptibility genes by increasing the likelihood of identifying functionally relevant genetic variants in the same genes in multiple families. A new consortium, COMPLEXO (a name chosen to reflect the complexity of the exome), has been formed to facilitate collaborations between researchers actively applying massively parallel sequencing to understand the genetics of breast and ovarian cancer. The consortium has defined activities aimed at bringing together data and resources suitable for exome/genome sequencing initiatives and for large case-control-family study resources suitable for validation of candidate susceptibility genes in which rare mutations are associated with high to moderate risk of breast cancer. The aim of COMPLEXO is to bring to massively parallel sequencing the same power of large sample sets that have proven so successful in examining the role of common variants in cancer populations via the consortium model, such as the Breast Cancer Association Consortium (BCAC), the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA), the Ovarian Cancer Association Consortium (OCAC) and the Collaborative Oncology Gene-environment Study (COGS) [<xref ref-type="bibr" rid="B3">3</xref>-<xref ref-type="bibr" rid="B5">5</xref>]. However, sequencing studies provide additional challenges in terms of defining specific modes of collaboration given differences in sequencing and targeted capture platforms, bioinformatics platforms, the need to integrate ongoing studies in many centers and socio-ethical-legal issues that are not as relevant to initiatives that are genotyping common genetic variation.</p><p>COMPLEXO invites collaboration from any researcher who would like to contribute to this consortium either by contributing data to the combined COMPLEXO data set, contributing resources for large-scale validation of candidate breast cancer predisposition genes or refining analytical and bioinformatic pipelines for massively parallel sequencing data filtering and prioritization. COMPLEXO also has interests in the critical assessment of current platforms and protocols and in developing and improving data filtering and gene prioritization strategies to enhance gene discovery initiatives. These approaches are relevant to all complex human diseases.</p><p>Interested researchers can engage with COMPLEXO via any local member or by contacting the corresponding author.</p></sec><sec><title>Competing interests</title><p>The authors declare that they have no competing interests.</p></sec></body><back><sec><title>Acknowledgements</title><p>MCS is a National Health and Medical Research Council (Australia), Senior Research Fellow and Victorian Breast Cancer Research Consortium Group Leader. TN-D is a Susan G Komen for the Cure Postdoctoral Fellow. FJC is supported by the Breast Cancer Research Foundation. JB is the Head of Human Cancer Genetics Programme and coordinator of the Familial Cancer Exome Project in the Network of Research in Rare Diseases (CIBERER). SLN is the Morris and Horowitz Families Professor in Cancer Etiology and Outcomes Research. IGC is an NHMRC Principal Research Fellow. KO acknowledges grant support from Breast Cancer Reseach Foundation, Geoffrey Beene Cancer Research Foundation and STARR Cancer Consortium. JS is Chairholder of the Canada Research Chair in Oncogenetics. ERT is the recipient of a National Breast Cancer Foundation (Australia) Postdoctoral Training Fellowship. 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