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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Difference in absolute CD4+ count according to CD4 percentage between Asian and Caucasian HIV-infected patients</title><author><name sortKey="Achhra, Amit C" sort="Achhra, Amit C" uniqKey="Achhra A" first="Amit C" last="Achhra">Amit C. Achhra</name><affiliation><nlm:aff id="A1"> National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia.</nlm:aff></affiliation></author><author><name sortKey="Zhou, Jialun" sort="Zhou, Jialun" uniqKey="Zhou J" first="Jialun" last="Zhou">Jialun Zhou</name><affiliation><nlm:aff id="A1"> National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia.</nlm:aff></affiliation></author><author><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name><affiliation><nlm:aff id="A2"> INSERM U897, Institut de Santé Publique d’Epidémiologie et de Développement (ISPED), Université Victor Segalen Bordeaux 2, Bordeaux, France.</nlm:aff></affiliation></author><author><name sortKey="Pujari, Sanjay" sort="Pujari, Sanjay" uniqKey="Pujari S" first="Sanjay" last="Pujari">Sanjay Pujari</name><affiliation><nlm:aff id="A3"> Ruby Hall Clinic, Pune, India.</nlm:aff></affiliation></author><author><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiebaut">Rodolphe Thiebaut</name><affiliation><nlm:aff id="A2"> INSERM U897, Institut de Santé Publique d’Epidémiologie et de Développement (ISPED), Université Victor Segalen Bordeaux 2, Bordeaux, France.</nlm:aff></affiliation></author><author><name sortKey="Law, Matthew G" sort="Law, Matthew G" uniqKey="Law M" first="Matthew G" last="Law">Matthew G. Law</name><affiliation><nlm:aff id="A1"> National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia.</nlm:aff></affiliation></author><author><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name><affiliation><nlm:aff id="A2"> INSERM U897, Institut de Santé Publique d’Epidémiologie et de Développement (ISPED), Université Victor Segalen Bordeaux 2, Bordeaux, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Service de Medecine Interne et Maladies Infectieuses, CHU de Bordeaux, France.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21479149</idno><idno type="pmc">3071513</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071513</idno><idno type="RBID">PMC:3071513</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">001541</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001541</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Difference in absolute CD4+ count according to CD4 percentage between Asian and Caucasian HIV-infected patients</title><author><name sortKey="Achhra, Amit C" sort="Achhra, Amit C" uniqKey="Achhra A" first="Amit C" last="Achhra">Amit C. Achhra</name><affiliation><nlm:aff id="A1"> National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia.</nlm:aff></affiliation></author><author><name sortKey="Zhou, Jialun" sort="Zhou, Jialun" uniqKey="Zhou J" first="Jialun" last="Zhou">Jialun Zhou</name><affiliation><nlm:aff id="A1"> National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia.</nlm:aff></affiliation></author><author><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name><affiliation><nlm:aff id="A2"> INSERM U897, Institut de Santé Publique d’Epidémiologie et de Développement (ISPED), Université Victor Segalen Bordeaux 2, Bordeaux, France.</nlm:aff></affiliation></author><author><name sortKey="Pujari, Sanjay" sort="Pujari, Sanjay" uniqKey="Pujari S" first="Sanjay" last="Pujari">Sanjay Pujari</name><affiliation><nlm:aff id="A3"> Ruby Hall Clinic, Pune, India.</nlm:aff></affiliation></author><author><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiebaut">Rodolphe Thiebaut</name><affiliation><nlm:aff id="A2"> INSERM U897, Institut de Santé Publique d’Epidémiologie et de Développement (ISPED), Université Victor Segalen Bordeaux 2, Bordeaux, France.</nlm:aff></affiliation></author><author><name sortKey="Law, Matthew G" sort="Law, Matthew G" uniqKey="Law M" first="Matthew G" last="Law">Matthew G. Law</name><affiliation><nlm:aff id="A1"> National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia.</nlm:aff></affiliation></author><author><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name><affiliation><nlm:aff id="A2"> INSERM U897, Institut de Santé Publique d’Epidémiologie et de Développement (ISPED), Université Victor Segalen Bordeaux 2, Bordeaux, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Service de Medecine Interne et Maladies Infectieuses, CHU de Bordeaux, France.</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of AIDS & clinical research</title><idno type="eISSN">2155-6113</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">We compared the absolute CD4+ count, at different CD4+ percentages (CD4%), between Asian (n=442) and Caucasian (n=674) untreated HIV-infected individuals, using linear regression methods. At any given CD4%, Asians had lower CD4+ count than Caucasians (p=0.001). The difference varied from 38.9 cells/mm<sup>3</sup> (95% CI: 3.3-74.5 cells/mm<sup>3</sup>) at CD4% of 15% to 108.7 cells/mm<sup>3</sup> (95% CI: 42.5-174.9 cells/mm<sup>3</sup>) at CD4% of 40%. The impact of these differences on prognosis is uncertain, but it may be that the prognostic thresholds for CD4+ count used in Caucasian populations are inappropriate in Asian populations.</p></div></front></TEI><pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101550222</journal-id><journal-id journal-id-type="pubmed-jr-id">38935</journal-id><journal-id journal-id-type="nlm-ta">J AIDS Clin Res</journal-id><journal-title-group><journal-title>Journal of AIDS & clinical research</journal-title></journal-title-group><issn pub-type="epub">2155-6113</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21479149</article-id><article-id pub-id-type="pmc">3071513</article-id><article-id pub-id-type="manuscript">NIHMS249406</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Difference in absolute CD4+ count according to CD4 percentage between Asian and Caucasian HIV-infected patients</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Achhra</surname><given-names>Amit C</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Jialun</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Dabis</surname><given-names>Francois</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Pujari</surname><given-names>Sanjay</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Thiebaut</surname><given-names>Rodolphe</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Law</surname><given-names>Matthew G</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bonnet</surname><given-names>Fabrice</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A4">4</xref></contrib><on-behalf-of>for the TREAT Asia HIV Observational Database (TAHOD) and ANRS CO3 Aquitaine Cohort.</on-behalf-of></contrib-group><aff id="A1"><label>1</label> National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia.</aff><aff id="A2"><label>2</label> INSERM U897, Institut de Santé Publique d’Epidémiologie et de Développement (ISPED), Université Victor Segalen Bordeaux 2, Bordeaux, France.</aff><aff id="A3"><label>3</label> Ruby Hall Clinic, Pune, India.</aff><aff id="A4"><label>4</label>Service de Medecine Interne et Maladies Infectieuses, CHU de Bordeaux, France.</aff><author-notes><corresp id="CR1">Correspondence and request for reprint to Amit C. Achhra, National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Cliffbrook Campus, 45 Beach Street, Coogee, NSW 2034, Sydney, Australia. Tel: +612 9385 0900, Fax: +612 9385 0920, <email>achhra@nchecr.unsw.edu.au</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>30</day><month>3</month><year>2011</year></pub-date><pub-date pub-type="ppub"><day>8</day><month>10</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>6</day><month>4</month><year>2011</year></pub-date><volume>1</volume><issue>1</issue><fpage>1</fpage><lpage>4</lpage><self-uri xlink:href="http://www.omicsonline.org/2155-6113/2155-6113-1-101.php"></self-uri><abstract><p id="P1">We compared the absolute CD4+ count, at different CD4+ percentages (CD4%), between Asian (n=442) and Caucasian (n=674) untreated HIV-infected individuals, using linear regression methods. At any given CD4%, Asians had lower CD4+ count than Caucasians (p=0.001). The difference varied from 38.9 cells/mm<sup>3</sup> (95% CI: 3.3-74.5 cells/mm<sup>3</sup>) at CD4% of 15% to 108.7 cells/mm<sup>3</sup> (95% CI: 42.5-174.9 cells/mm<sup>3</sup>) at CD4% of 40%. The impact of these differences on prognosis is uncertain, but it may be that the prognostic thresholds for CD4+ count used in Caucasian populations are inappropriate in Asian populations.</p></abstract><kwd-group><kwd>race</kwd><kwd>CD4+ count</kwd><kwd>CD4+</kwd><kwd>Asian</kwd><kwd>Caucasian</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source><award-id>U01 AI069907-01 || AI</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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