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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The <italic>CALHM1</italic> P86L polymorphism is a genetic modifier of age at onset in Alzheimer’s disease: a meta-analysis study</title><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation><nlm:aff id="A1"> INSERM U744, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Institut Pasteur de Lille, F-59019, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Université de Lille Nord de France, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Sleegers, Kristel" sort="Sleegers, Kristel" uniqKey="Sleegers K" first="Kristel" last="Sleegers">Kristel Sleegers</name><affiliation><nlm:aff id="A4"> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Perez, Antonio" sort="Gonzalez Perez, Antonio" uniqKey="Gonzalez Perez A" first="Antonio" last="González-Pérez">Antonio González-Pérez</name><affiliation><nlm:aff id="A6"> Department of Structural Genomics. Neocodex, Sevilla, Spain</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Martin" sort="Ingelsson, Martin" uniqKey="Ingelsson M" first="Martin" last="Ingelsson">Martin Ingelsson</name><affiliation><nlm:aff id="A7"> Uppsala University, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W" last="Beecham">Gary W. Beecham</name><affiliation><nlm:aff id="A8"> John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, USA</nlm:aff></affiliation></author><author><name sortKey="Hiltunen, Mikko" sort="Hiltunen, Mikko" uniqKey="Hiltunen M" first="Mikko" last="Hiltunen">Mikko Hiltunen</name><affiliation><nlm:aff id="A9"> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Combarros, Onofre" sort="Combarros, Onofre" uniqKey="Combarros O" first="Onofre" last="Combarros">Onofre Combarros</name><affiliation><nlm:aff id="A10"> Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain</nlm:aff></affiliation></author><author><name sortKey="Bullido, Maria J" sort="Bullido, Maria J" uniqKey="Bullido M" first="Maria J" last="Bullido">Maria J. Bullido</name><affiliation><nlm:aff id="A11"> Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) and CIBERNED, Universidad Autonoma, Cantoblanco, S-28049, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Brouwers, Nathalie" sort="Brouwers, Nathalie" uniqKey="Brouwers N" first="Nathalie" last="Brouwers">Nathalie Brouwers</name><affiliation><nlm:aff id="A4"> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation></author><author><name sortKey="Bettens, Karolien" sort="Bettens, Karolien" uniqKey="Bettens K" first="Karolien" last="Bettens">Karolien Bettens</name><affiliation><nlm:aff id="A4"> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation></author><author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><affiliation><nlm:aff id="A12"> INSERM U888, Hôpital La Colombière, F-34093 Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><affiliation><nlm:aff id="A3"> Université de Lille Nord de France, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A13"> CHRU de Lille, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Richard, Florence" sort="Richard, Florence" uniqKey="Richard F" first="Florence" last="Richard">Florence Richard</name><affiliation><nlm:aff id="A1"> INSERM U744, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Institut Pasteur de Lille, F-59019, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Université de Lille Nord de France, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A13"> CHRU de Lille, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Dekosky, Steven T" sort="Dekosky, Steven T" uniqKey="Dekosky S" first="Steven T" last="Dekosky">Steven T. Dekosky</name><affiliation><nlm:aff id="A14"> University of Virginia School of medicine, Charlottesville, VA, USA</nlm:aff></affiliation></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><affiliation><nlm:aff id="A15"> INSERM U614, Faculté de Médecine-Pharmacie de Rouen, F-76183, Rouen, France</nlm:aff></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><affiliation><nlm:aff id="A16"> Vanderbilt Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, USA</nlm:aff></affiliation></author><author><name sortKey="Tognoni, Gloria" sort="Tognoni, Gloria" uniqKey="Tognoni G" first="Gloria" last="Tognoni">Gloria Tognoni</name><affiliation><nlm:aff id="A17"> Department of Neuroscience, Neurological Clinic, University of Pisa, I-56100, Italy</nlm:aff></affiliation></author><author><name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fiévet">Nathalie Fiévet</name><affiliation><nlm:aff id="A1"> INSERM U744, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Institut Pasteur de Lille, F-59019, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><affiliation><nlm:aff id="A18"> INSERM U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation><nlm:aff id="A19"> INSERM U708, F-75013 Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A20"> UPMC Univ. Paris 06, F-75005 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Engelborghs, Sebastiaan" sort="Engelborghs, Sebastiaan" uniqKey="Engelborghs S" first="Sebastiaan" last="Engelborghs">Sebastiaan Engelborghs</name><affiliation><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A21"> Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen, Belgium</nlm:aff></affiliation></author><author><name sortKey="Arosio, Beatrice" sort="Arosio, Beatrice" uniqKey="Arosio B" first="Beatrice" last="Arosio">Beatrice Arosio</name><affiliation><nlm:aff id="A22"> Department of Internal Medicine, Fondazione Policlinico IRCCS, Milan Italy</nlm:aff></affiliation></author><author><name sortKey="Coto, Elicer" sort="Coto, Elicer" uniqKey="Coto E" first="Elicer" last="Coto">Elicer Coto</name><affiliation><nlm:aff id="A23"> Genetic Molecular Unit, Hospital Universitario Central de Asturias, 33006-Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="De Deyn, Peter" sort="De Deyn, Peter" uniqKey="De Deyn P" first="Peter" last="De Deyn">Peter De Deyn</name><affiliation><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A21"> Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen, Belgium</nlm:aff></affiliation></author><author><name sortKey="Zompo, Maria Del" sort="Zompo, Maria Del" uniqKey="Zompo M" first="Maria Del" last="Zompo">Maria Del Zompo</name><affiliation><nlm:aff id="A24"> Section of Clinical Pharmacology, Department of Neuroscience, University of Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Mateo, Ignacio" sort="Mateo, Ignacio" uniqKey="Mateo I" first="Ignacio" last="Mateo">Ignacio Mateo</name><affiliation><nlm:aff id="A10"> Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain</nlm:aff></affiliation></author><author><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Merce" last="Boada">Merce Boada</name><affiliation><nlm:aff id="A25"> Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A26"> Neurology Department, Hospital G. Universitari Vall d’Hebron, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Antunez, Carmen" sort="Antunez, Carmen" uniqKey="Antunez C" first="Carmen" last="Antunez">Carmen Antunez</name><affiliation><nlm:aff id="A27"> Alzheimur Foundation, Murcia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> Dementia Unit. University Hospital Virgen de la Arrixaca, Murcia, Spain</nlm:aff></affiliation></author><author><name sortKey="Lopez Arrieta, Jesus" sort="Lopez Arrieta, Jesus" uniqKey="Lopez Arrieta J" first="Jesus" last="Lopez-Arrieta">Jesus Lopez-Arrieta</name><affiliation><nlm:aff id="A29"> Memory Unit. University Hospital La Paz- Cantoblanco, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Epelbaum, Jacques" sort="Epelbaum, Jacques" uniqKey="Epelbaum J" first="Jacques" last="Epelbaum">Jacques Epelbaum</name><affiliation><nlm:aff id="A30"> UMR 894, INSERM Faculté de Médecine, Université Paris Descartes, F-75014 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Schjeide, Brit Maren Michaud" sort="Schjeide, Brit Maren Michaud" uniqKey="Schjeide B" first="Brit-Maren Michaud" last="Schjeide">Brit-Maren Michaud Schjeide</name><affiliation><nlm:aff id="A31"> Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Frank Garcia, Ana" sort="Frank Garcia, Ana" uniqKey="Frank Garcia A" first="Ana" last="Frank-Garcia">Ana Frank-Garcia</name><affiliation><nlm:aff id="A32"> Servicio de Neurologia, Hospital Universitario La Paz (UAM) and CIBERNED, 28034 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Giedraitis, Vilmentas" sort="Giedraitis, Vilmentas" uniqKey="Giedraitis V" first="Vilmentas" last="Giedraitis">Vilmentas Giedraitis</name><affiliation><nlm:aff id="A7"> Uppsala University, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Helisalmi, Seppo" sort="Helisalmi, Seppo" uniqKey="Helisalmi S" first="Seppo" last="Helisalmi">Seppo Helisalmi</name><affiliation><nlm:aff id="A9"> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Porcellini, Elisa" sort="Porcellini, Elisa" uniqKey="Porcellini E" first="Elisa" last="Porcellini">Elisa Porcellini</name><affiliation><nlm:aff id="A33"> Department of Experimental Pathology, School of Medicine, University of Bologna, Italy</nlm:aff></affiliation></author><author><name sortKey="Pilotto, Alberto" sort="Pilotto, Alberto" uniqKey="Pilotto A" first="Alberto" last="Pilotto">Alberto Pilotto</name><affiliation><nlm:aff id="A34"> Geriatric Unit & Gerontology-Geriatric Research Laboratory, Department of Medical Science, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo , I-71013, Italy</nlm:aff></affiliation></author><author><name sortKey="Forti, Paola" sort="Forti, Paola" uniqKey="Forti P" first="Paola" last="Forti">Paola Forti</name><affiliation><nlm:aff id="A35"> Department of Internal Medicine Cardiology and Hepatology, University Hospital S. Orsola-Malpighi, Bologna, Italy</nlm:aff></affiliation></author><author><name sortKey="Ferri, Raffaele" sort="Ferri, Raffaele" uniqKey="Ferri R" first="Raffaele" last="Ferri">Raffaele Ferri</name><affiliation><nlm:aff id="A36"> IRCCS Oasi Maria SS, 94018 Troina , Italy</nlm:aff></affiliation></author><author><name sortKey="Delepine, Marc" sort="Delepine, Marc" uniqKey="Delepine M" first="Marc" last="Delepine">Marc Delepine</name><affiliation><nlm:aff id="A37"> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry, France</nlm:aff></affiliation></author><author><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name><affiliation><nlm:aff id="A37"> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry, France</nlm:aff></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:aff id="A37"> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry, France</nlm:aff></affiliation><affiliation><nlm:aff id="A38"> Fondation Jean Dausset-CEPH, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name><affiliation><nlm:aff id="A39"> Dept. of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Siciliano, Gabriele" sort="Siciliano, Gabriele" uniqKey="Siciliano G" first="Gabriele" last="Siciliano">Gabriele Siciliano</name><affiliation><nlm:aff id="A40"> Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, 70124 Bari, Italy</nlm:aff></affiliation></author><author><name sortKey="Solfrizzi, Vincenzo" sort="Solfrizzi, Vincenzo" uniqKey="Solfrizzi V" first="Vincenzo" last="Solfrizzi">Vincenzo Solfrizzi</name><affiliation><nlm:aff id="A41"> Department of Neurological and Psychiatric Sciences, 50134 Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name><affiliation><nlm:aff id="A42"> Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, 00179 Roma – Italy</nlm:aff></affiliation></author><author><name sortKey="Spalletta, Gianfranco" sort="Spalletta, Gianfranco" uniqKey="Spalletta G" first="Gianfranco" last="Spalletta">Gianfranco Spalletta</name><affiliation><nlm:aff id="A43"> Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Monza Italy</nlm:aff></affiliation></author><author><name sortKey="Ravaglia, Giovanni" sort="Ravaglia, Giovanni" uniqKey="Ravaglia G" first="Giovanni" last="Ravaglia">Giovanni Ravaglia</name><affiliation><nlm:aff id="A35"> Department of Internal Medicine Cardiology and Hepatology, University Hospital S. Orsola-Malpighi, Bologna, Italy</nlm:aff></affiliation></author><author><name sortKey="Valdivieso, Fernando" sort="Valdivieso, Fernando" uniqKey="Valdivieso F" first="Fernando" last="Valdivieso">Fernando Valdivieso</name><affiliation><nlm:aff id="A11"> Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) and CIBERNED, Universidad Autonoma, Cantoblanco, S-28049, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Veps L Inen, Saila" sort="Veps L Inen, Saila" uniqKey="Veps L Inen S" first="Saila" last="Veps L Inen">Saila Veps L Inen</name><affiliation><nlm:aff id="A9"> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name><affiliation><nlm:aff id="A23"> Genetic Molecular Unit, Hospital Universitario Central de Asturias, 33006-Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="Bosco, Paolo" sort="Bosco, Paolo" uniqKey="Bosco P" first="Paolo" last="Bosco">Paolo Bosco</name><affiliation><nlm:aff id="A36"> IRCCS Oasi Maria SS, 94018 Troina , Italy</nlm:aff></affiliation></author><author><name sortKey="Mancuso, Michelangelo" sort="Mancuso, Michelangelo" uniqKey="Mancuso M" first="Michelangelo" last="Mancuso">Michelangelo Mancuso</name><affiliation><nlm:aff id="A17"> Department of Neuroscience, Neurological Clinic, University of Pisa, I-56100, Italy</nlm:aff></affiliation></author><author><name sortKey="Panza, Francesco" sort="Panza, Francesco" uniqKey="Panza F" first="Francesco" last="Panza">Francesco Panza</name><affiliation><nlm:aff id="A40"> Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, 70124 Bari, Italy</nlm:aff></affiliation></author><author><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name><affiliation><nlm:aff id="A41"> Department of Neurological and Psychiatric Sciences, 50134 Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Bossu, Paola" sort="Bossu, Paola" uniqKey="Bossu P" first="Paola" last="Bossù">Paola Bossù</name><affiliation><nlm:aff id="A42"> Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, 00179 Roma – Italy</nlm:aff></affiliation></author><author><name sortKey="Hanon, Olivier" sort="Hanon, Olivier" uniqKey="Hanon O" first="Olivier" last="Hanon">Olivier Hanon</name><affiliation><nlm:aff id="A30"> UMR 894, INSERM Faculté de Médecine, Université Paris Descartes, F-75014 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Piccardi, Paola" sort="Piccardi, Paola" uniqKey="Piccardi P" first="Paola" last="Piccardi">Paola Piccardi</name><affiliation><nlm:aff id="A24"> Section of Clinical Pharmacology, Department of Neuroscience, University of Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Annoni, Giorgio" sort="Annoni, Giorgio" uniqKey="Annoni G" first="Giorgio" last="Annoni">Giorgio Annoni</name><affiliation><nlm:aff id="A43"> Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Monza Italy</nlm:aff></affiliation></author><author><name sortKey="Mann, David" sort="Mann, David" uniqKey="Mann D" first="David" last="Mann">David Mann</name><affiliation><nlm:aff id="A44"> Greater Manchester Neuroscience Centre, University of Manchester, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Marambaud, Philippe" sort="Marambaud, Philippe" uniqKey="Marambaud P" first="Philippe" last="Marambaud">Philippe Marambaud</name><affiliation><nlm:aff id="A45"> Litwin-Zucker Research Center for the Study of Alzheimer's Disease, Feinstein Institute for Medical Research, North Shore-LIJ, Manhasset, NY, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A46"> Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Seripa, Davide" sort="Seripa, Davide" uniqKey="Seripa D" first="Davide" last="Seripa">Davide Seripa</name><affiliation><nlm:aff id="A34"> Geriatric Unit & Gerontology-Geriatric Research Laboratory, Department of Medical Science, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo , I-71013, Italy</nlm:aff></affiliation></author><author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><affiliation><nlm:aff id="A39"> Dept. of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Tanzi, Rudolph E" sort="Tanzi, Rudolph E" uniqKey="Tanzi R" first="Rudolph E" last="Tanzi">Rudolph E. Tanzi</name><affiliation><nlm:aff id="A47"> Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, MA 02129</nlm:aff></affiliation></author><author><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><affiliation><nlm:aff id="A31"> Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Lendon, Corinne" sort="Lendon, Corinne" uniqKey="Lendon C" first="Corinne" last="Lendon">Corinne Lendon</name><affiliation><nlm:aff id="A48"> Molecular Psychiatry Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Lannfelt, Lars" sort="Lannfelt, Lars" uniqKey="Lannfelt L" first="Lars" last="Lannfelt">Lars Lannfelt</name><affiliation><nlm:aff id="A7"> Uppsala University, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Licastro, Federico" sort="Licastro, Federico" uniqKey="Licastro F" first="Federico" last="Licastro">Federico Licastro</name><affiliation><nlm:aff id="A33"> Department of Experimental Pathology, School of Medicine, University of Bologna, Italy</nlm:aff></affiliation></author><author><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><affiliation><nlm:aff id="A15"> INSERM U614, Faculté de Médecine-Pharmacie de Rouen, F-76183, Rouen, France</nlm:aff></affiliation></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A" last="Pericak-Vance">Margaret A. Pericak-Vance</name><affiliation><nlm:aff id="A8"> John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, USA</nlm:aff></affiliation></author><author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name><affiliation><nlm:aff id="A9"> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation><nlm:aff id="A4"> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation></author><author><name sortKey="Alperovitch, Annick" sort="Alperovitch, Annick" uniqKey="Alperovitch A" first="Annick" last="Alpérovitch">Annick Alpérovitch</name><affiliation><nlm:aff id="A19"> INSERM U708, F-75013 Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A20"> UPMC Univ. Paris 06, F-75005 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Ruiz, Agustin" sort="Ruiz, Agustin" uniqKey="Ruiz A" first="Agustin" last="Ruiz">Agustin Ruiz</name><affiliation><nlm:aff id="A6"> Department of Structural Genomics. Neocodex, Sevilla, Spain</nlm:aff></affiliation></author><author><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M Ilyas" last="Kamboh">M Ilyas Kamboh</name><affiliation><nlm:aff id="A49"> Department of Human Genetics and Alzheimer's Disease Research Centre, University of Pittsburgh, USA</nlm:aff></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation><nlm:aff id="A1"> INSERM U744, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Institut Pasteur de Lille, F-59019, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Université de Lille Nord de France, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A13"> CHRU de Lille, F-59000 Lille, France</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20847397</idno><idno type="pmc">2964875</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964875</idno><idno type="RBID">PMC:2964875</idno><idno type="doi">10.3233/JAD-2010-100933</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">001498</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001498</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The <italic>CALHM1</italic> P86L polymorphism is a genetic modifier of age at onset in Alzheimer’s disease: a meta-analysis study</title><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation><nlm:aff id="A1"> INSERM U744, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Institut Pasteur de Lille, F-59019, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Université de Lille Nord de France, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Sleegers, Kristel" sort="Sleegers, Kristel" uniqKey="Sleegers K" first="Kristel" last="Sleegers">Kristel Sleegers</name><affiliation><nlm:aff id="A4"> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Perez, Antonio" sort="Gonzalez Perez, Antonio" uniqKey="Gonzalez Perez A" first="Antonio" last="González-Pérez">Antonio González-Pérez</name><affiliation><nlm:aff id="A6"> Department of Structural Genomics. Neocodex, Sevilla, Spain</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Martin" sort="Ingelsson, Martin" uniqKey="Ingelsson M" first="Martin" last="Ingelsson">Martin Ingelsson</name><affiliation><nlm:aff id="A7"> Uppsala University, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W" last="Beecham">Gary W. Beecham</name><affiliation><nlm:aff id="A8"> John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, USA</nlm:aff></affiliation></author><author><name sortKey="Hiltunen, Mikko" sort="Hiltunen, Mikko" uniqKey="Hiltunen M" first="Mikko" last="Hiltunen">Mikko Hiltunen</name><affiliation><nlm:aff id="A9"> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Combarros, Onofre" sort="Combarros, Onofre" uniqKey="Combarros O" first="Onofre" last="Combarros">Onofre Combarros</name><affiliation><nlm:aff id="A10"> Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain</nlm:aff></affiliation></author><author><name sortKey="Bullido, Maria J" sort="Bullido, Maria J" uniqKey="Bullido M" first="Maria J" last="Bullido">Maria J. Bullido</name><affiliation><nlm:aff id="A11"> Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) and CIBERNED, Universidad Autonoma, Cantoblanco, S-28049, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Brouwers, Nathalie" sort="Brouwers, Nathalie" uniqKey="Brouwers N" first="Nathalie" last="Brouwers">Nathalie Brouwers</name><affiliation><nlm:aff id="A4"> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation></author><author><name sortKey="Bettens, Karolien" sort="Bettens, Karolien" uniqKey="Bettens K" first="Karolien" last="Bettens">Karolien Bettens</name><affiliation><nlm:aff id="A4"> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation></author><author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><affiliation><nlm:aff id="A12"> INSERM U888, Hôpital La Colombière, F-34093 Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><affiliation><nlm:aff id="A3"> Université de Lille Nord de France, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A13"> CHRU de Lille, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Richard, Florence" sort="Richard, Florence" uniqKey="Richard F" first="Florence" last="Richard">Florence Richard</name><affiliation><nlm:aff id="A1"> INSERM U744, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Institut Pasteur de Lille, F-59019, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Université de Lille Nord de France, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A13"> CHRU de Lille, F-59000 Lille, France</nlm:aff></affiliation></author><author><name sortKey="Dekosky, Steven T" sort="Dekosky, Steven T" uniqKey="Dekosky S" first="Steven T" last="Dekosky">Steven T. Dekosky</name><affiliation><nlm:aff id="A14"> University of Virginia School of medicine, Charlottesville, VA, USA</nlm:aff></affiliation></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><affiliation><nlm:aff id="A15"> INSERM U614, Faculté de Médecine-Pharmacie de Rouen, F-76183, Rouen, France</nlm:aff></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><affiliation><nlm:aff id="A16"> Vanderbilt Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, USA</nlm:aff></affiliation></author><author><name sortKey="Tognoni, Gloria" sort="Tognoni, Gloria" uniqKey="Tognoni G" first="Gloria" last="Tognoni">Gloria Tognoni</name><affiliation><nlm:aff id="A17"> Department of Neuroscience, Neurological Clinic, University of Pisa, I-56100, Italy</nlm:aff></affiliation></author><author><name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fiévet">Nathalie Fiévet</name><affiliation><nlm:aff id="A1"> INSERM U744, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Institut Pasteur de Lille, F-59019, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><affiliation><nlm:aff id="A18"> INSERM U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation><nlm:aff id="A19"> INSERM U708, F-75013 Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A20"> UPMC Univ. Paris 06, F-75005 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Engelborghs, Sebastiaan" sort="Engelborghs, Sebastiaan" uniqKey="Engelborghs S" first="Sebastiaan" last="Engelborghs">Sebastiaan Engelborghs</name><affiliation><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A21"> Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen, Belgium</nlm:aff></affiliation></author><author><name sortKey="Arosio, Beatrice" sort="Arosio, Beatrice" uniqKey="Arosio B" first="Beatrice" last="Arosio">Beatrice Arosio</name><affiliation><nlm:aff id="A22"> Department of Internal Medicine, Fondazione Policlinico IRCCS, Milan Italy</nlm:aff></affiliation></author><author><name sortKey="Coto, Elicer" sort="Coto, Elicer" uniqKey="Coto E" first="Elicer" last="Coto">Elicer Coto</name><affiliation><nlm:aff id="A23"> Genetic Molecular Unit, Hospital Universitario Central de Asturias, 33006-Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="De Deyn, Peter" sort="De Deyn, Peter" uniqKey="De Deyn P" first="Peter" last="De Deyn">Peter De Deyn</name><affiliation><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A21"> Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen, Belgium</nlm:aff></affiliation></author><author><name sortKey="Zompo, Maria Del" sort="Zompo, Maria Del" uniqKey="Zompo M" first="Maria Del" last="Zompo">Maria Del Zompo</name><affiliation><nlm:aff id="A24"> Section of Clinical Pharmacology, Department of Neuroscience, University of Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Mateo, Ignacio" sort="Mateo, Ignacio" uniqKey="Mateo I" first="Ignacio" last="Mateo">Ignacio Mateo</name><affiliation><nlm:aff id="A10"> Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain</nlm:aff></affiliation></author><author><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Merce" last="Boada">Merce Boada</name><affiliation><nlm:aff id="A25"> Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A26"> Neurology Department, Hospital G. Universitari Vall d’Hebron, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Antunez, Carmen" sort="Antunez, Carmen" uniqKey="Antunez C" first="Carmen" last="Antunez">Carmen Antunez</name><affiliation><nlm:aff id="A27"> Alzheimur Foundation, Murcia, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A28"> Dementia Unit. University Hospital Virgen de la Arrixaca, Murcia, Spain</nlm:aff></affiliation></author><author><name sortKey="Lopez Arrieta, Jesus" sort="Lopez Arrieta, Jesus" uniqKey="Lopez Arrieta J" first="Jesus" last="Lopez-Arrieta">Jesus Lopez-Arrieta</name><affiliation><nlm:aff id="A29"> Memory Unit. University Hospital La Paz- Cantoblanco, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Epelbaum, Jacques" sort="Epelbaum, Jacques" uniqKey="Epelbaum J" first="Jacques" last="Epelbaum">Jacques Epelbaum</name><affiliation><nlm:aff id="A30"> UMR 894, INSERM Faculté de Médecine, Université Paris Descartes, F-75014 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Schjeide, Brit Maren Michaud" sort="Schjeide, Brit Maren Michaud" uniqKey="Schjeide B" first="Brit-Maren Michaud" last="Schjeide">Brit-Maren Michaud Schjeide</name><affiliation><nlm:aff id="A31"> Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Frank Garcia, Ana" sort="Frank Garcia, Ana" uniqKey="Frank Garcia A" first="Ana" last="Frank-Garcia">Ana Frank-Garcia</name><affiliation><nlm:aff id="A32"> Servicio de Neurologia, Hospital Universitario La Paz (UAM) and CIBERNED, 28034 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Giedraitis, Vilmentas" sort="Giedraitis, Vilmentas" uniqKey="Giedraitis V" first="Vilmentas" last="Giedraitis">Vilmentas Giedraitis</name><affiliation><nlm:aff id="A7"> Uppsala University, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Helisalmi, Seppo" sort="Helisalmi, Seppo" uniqKey="Helisalmi S" first="Seppo" last="Helisalmi">Seppo Helisalmi</name><affiliation><nlm:aff id="A9"> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Porcellini, Elisa" sort="Porcellini, Elisa" uniqKey="Porcellini E" first="Elisa" last="Porcellini">Elisa Porcellini</name><affiliation><nlm:aff id="A33"> Department of Experimental Pathology, School of Medicine, University of Bologna, Italy</nlm:aff></affiliation></author><author><name sortKey="Pilotto, Alberto" sort="Pilotto, Alberto" uniqKey="Pilotto A" first="Alberto" last="Pilotto">Alberto Pilotto</name><affiliation><nlm:aff id="A34"> Geriatric Unit & Gerontology-Geriatric Research Laboratory, Department of Medical Science, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo , I-71013, Italy</nlm:aff></affiliation></author><author><name sortKey="Forti, Paola" sort="Forti, Paola" uniqKey="Forti P" first="Paola" last="Forti">Paola Forti</name><affiliation><nlm:aff id="A35"> Department of Internal Medicine Cardiology and Hepatology, University Hospital S. Orsola-Malpighi, Bologna, Italy</nlm:aff></affiliation></author><author><name sortKey="Ferri, Raffaele" sort="Ferri, Raffaele" uniqKey="Ferri R" first="Raffaele" last="Ferri">Raffaele Ferri</name><affiliation><nlm:aff id="A36"> IRCCS Oasi Maria SS, 94018 Troina , Italy</nlm:aff></affiliation></author><author><name sortKey="Delepine, Marc" sort="Delepine, Marc" uniqKey="Delepine M" first="Marc" last="Delepine">Marc Delepine</name><affiliation><nlm:aff id="A37"> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry, France</nlm:aff></affiliation></author><author><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name><affiliation><nlm:aff id="A37"> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry, France</nlm:aff></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:aff id="A37"> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry, France</nlm:aff></affiliation><affiliation><nlm:aff id="A38"> Fondation Jean Dausset-CEPH, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name><affiliation><nlm:aff id="A39"> Dept. of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Siciliano, Gabriele" sort="Siciliano, Gabriele" uniqKey="Siciliano G" first="Gabriele" last="Siciliano">Gabriele Siciliano</name><affiliation><nlm:aff id="A40"> Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, 70124 Bari, Italy</nlm:aff></affiliation></author><author><name sortKey="Solfrizzi, Vincenzo" sort="Solfrizzi, Vincenzo" uniqKey="Solfrizzi V" first="Vincenzo" last="Solfrizzi">Vincenzo Solfrizzi</name><affiliation><nlm:aff id="A41"> Department of Neurological and Psychiatric Sciences, 50134 Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name><affiliation><nlm:aff id="A42"> Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, 00179 Roma – Italy</nlm:aff></affiliation></author><author><name sortKey="Spalletta, Gianfranco" sort="Spalletta, Gianfranco" uniqKey="Spalletta G" first="Gianfranco" last="Spalletta">Gianfranco Spalletta</name><affiliation><nlm:aff id="A43"> Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Monza Italy</nlm:aff></affiliation></author><author><name sortKey="Ravaglia, Giovanni" sort="Ravaglia, Giovanni" uniqKey="Ravaglia G" first="Giovanni" last="Ravaglia">Giovanni Ravaglia</name><affiliation><nlm:aff id="A35"> Department of Internal Medicine Cardiology and Hepatology, University Hospital S. Orsola-Malpighi, Bologna, Italy</nlm:aff></affiliation></author><author><name sortKey="Valdivieso, Fernando" sort="Valdivieso, Fernando" uniqKey="Valdivieso F" first="Fernando" last="Valdivieso">Fernando Valdivieso</name><affiliation><nlm:aff id="A11"> Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) and CIBERNED, Universidad Autonoma, Cantoblanco, S-28049, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Veps L Inen, Saila" sort="Veps L Inen, Saila" uniqKey="Veps L Inen S" first="Saila" last="Veps L Inen">Saila Veps L Inen</name><affiliation><nlm:aff id="A9"> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name><affiliation><nlm:aff id="A23"> Genetic Molecular Unit, Hospital Universitario Central de Asturias, 33006-Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="Bosco, Paolo" sort="Bosco, Paolo" uniqKey="Bosco P" first="Paolo" last="Bosco">Paolo Bosco</name><affiliation><nlm:aff id="A36"> IRCCS Oasi Maria SS, 94018 Troina , Italy</nlm:aff></affiliation></author><author><name sortKey="Mancuso, Michelangelo" sort="Mancuso, Michelangelo" uniqKey="Mancuso M" first="Michelangelo" last="Mancuso">Michelangelo Mancuso</name><affiliation><nlm:aff id="A17"> Department of Neuroscience, Neurological Clinic, University of Pisa, I-56100, Italy</nlm:aff></affiliation></author><author><name sortKey="Panza, Francesco" sort="Panza, Francesco" uniqKey="Panza F" first="Francesco" last="Panza">Francesco Panza</name><affiliation><nlm:aff id="A40"> Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, 70124 Bari, Italy</nlm:aff></affiliation></author><author><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name><affiliation><nlm:aff id="A41"> Department of Neurological and Psychiatric Sciences, 50134 Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Bossu, Paola" sort="Bossu, Paola" uniqKey="Bossu P" first="Paola" last="Bossù">Paola Bossù</name><affiliation><nlm:aff id="A42"> Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, 00179 Roma – Italy</nlm:aff></affiliation></author><author><name sortKey="Hanon, Olivier" sort="Hanon, Olivier" uniqKey="Hanon O" first="Olivier" last="Hanon">Olivier Hanon</name><affiliation><nlm:aff id="A30"> UMR 894, INSERM Faculté de Médecine, Université Paris Descartes, F-75014 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Piccardi, Paola" sort="Piccardi, Paola" uniqKey="Piccardi P" first="Paola" last="Piccardi">Paola Piccardi</name><affiliation><nlm:aff id="A24"> Section of Clinical Pharmacology, Department of Neuroscience, University of Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Annoni, Giorgio" sort="Annoni, Giorgio" uniqKey="Annoni G" first="Giorgio" last="Annoni">Giorgio Annoni</name><affiliation><nlm:aff id="A43"> Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Monza Italy</nlm:aff></affiliation></author><author><name sortKey="Mann, David" sort="Mann, David" uniqKey="Mann D" first="David" last="Mann">David Mann</name><affiliation><nlm:aff id="A44"> Greater Manchester Neuroscience Centre, University of Manchester, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Marambaud, Philippe" sort="Marambaud, Philippe" uniqKey="Marambaud P" first="Philippe" last="Marambaud">Philippe Marambaud</name><affiliation><nlm:aff id="A45"> Litwin-Zucker Research Center for the Study of Alzheimer's Disease, Feinstein Institute for Medical Research, North Shore-LIJ, Manhasset, NY, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A46"> Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Seripa, Davide" sort="Seripa, Davide" uniqKey="Seripa D" first="Davide" last="Seripa">Davide Seripa</name><affiliation><nlm:aff id="A34"> Geriatric Unit & Gerontology-Geriatric Research Laboratory, Department of Medical Science, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo , I-71013, Italy</nlm:aff></affiliation></author><author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><affiliation><nlm:aff id="A39"> Dept. of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Tanzi, Rudolph E" sort="Tanzi, Rudolph E" uniqKey="Tanzi R" first="Rudolph E" last="Tanzi">Rudolph E. Tanzi</name><affiliation><nlm:aff id="A47"> Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, MA 02129</nlm:aff></affiliation></author><author><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><affiliation><nlm:aff id="A31"> Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Lendon, Corinne" sort="Lendon, Corinne" uniqKey="Lendon C" first="Corinne" last="Lendon">Corinne Lendon</name><affiliation><nlm:aff id="A48"> Molecular Psychiatry Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029, Australia</nlm:aff></affiliation></author><author><name sortKey="Lannfelt, Lars" sort="Lannfelt, Lars" uniqKey="Lannfelt L" first="Lars" last="Lannfelt">Lars Lannfelt</name><affiliation><nlm:aff id="A7"> Uppsala University, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Licastro, Federico" sort="Licastro, Federico" uniqKey="Licastro F" first="Federico" last="Licastro">Federico Licastro</name><affiliation><nlm:aff id="A33"> Department of Experimental Pathology, School of Medicine, University of Bologna, Italy</nlm:aff></affiliation></author><author><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><affiliation><nlm:aff id="A15"> INSERM U614, Faculté de Médecine-Pharmacie de Rouen, F-76183, Rouen, France</nlm:aff></affiliation></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A" last="Pericak-Vance">Margaret A. Pericak-Vance</name><affiliation><nlm:aff id="A8"> John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, USA</nlm:aff></affiliation></author><author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name><affiliation><nlm:aff id="A9"> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation><nlm:aff id="A4"> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation></author><author><name sortKey="Alperovitch, Annick" sort="Alperovitch, Annick" uniqKey="Alperovitch A" first="Annick" last="Alpérovitch">Annick Alpérovitch</name><affiliation><nlm:aff id="A19"> INSERM U708, F-75013 Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A20"> UPMC Univ. Paris 06, F-75005 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Ruiz, Agustin" sort="Ruiz, Agustin" uniqKey="Ruiz A" first="Agustin" last="Ruiz">Agustin Ruiz</name><affiliation><nlm:aff id="A6"> Department of Structural Genomics. Neocodex, Sevilla, Spain</nlm:aff></affiliation></author><author><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M Ilyas" last="Kamboh">M Ilyas Kamboh</name><affiliation><nlm:aff id="A49"> Department of Human Genetics and Alzheimer's Disease Research Centre, University of Pittsburgh, USA</nlm:aff></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation><nlm:aff id="A1"> INSERM U744, F-59019 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Institut Pasteur de Lille, F-59019, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Université de Lille Nord de France, F-59000 Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A13"> CHRU de Lille, F-59000 Lille, France</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Alzheimer's disease : JAD</title><idno type="ISSN">1387-2877</idno><idno type="eISSN">1875-8908</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The only established genetic determinant of non-Mendelian forms of Alzheimer’s disease (AD) is the ε4 allele of the apolipoprotein E gene (<italic>APOE</italic>). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (<italic>CALHM1</italic>) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centres in Belgium, Finland, France, Italy, Spain, Sweden, the UK and the USA). Our results indicate that the <italic>CALHM1</italic> P86L polymorphism is likely not a genetic determinant of AD but may modulate age at onset by interacting with the effect of the ε4 allele of the <italic>APOE</italic> gene.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9814863</journal-id><journal-id journal-id-type="pubmed-jr-id">21942</journal-id><journal-id journal-id-type="nlm-ta">J Alzheimers Dis</journal-id><journal-title>Journal of Alzheimer's disease : JAD</journal-title><issn pub-type="ppub">1387-2877</issn><issn pub-type="epub">1875-8908</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20847397</article-id><article-id pub-id-type="pmc">2964875</article-id><article-id pub-id-type="doi">10.3233/JAD-2010-100933</article-id><article-id pub-id-type="manuscript">NIHMS240115</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The <italic>CALHM1</italic> P86L polymorphism is a genetic modifier of age at onset in Alzheimer’s disease: a meta-analysis study</article-title></title-group><contrib-group><contrib 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rid="A23" ref-type="aff">23</xref></contrib><contrib contrib-type="author"><name><surname>De Deyn</surname><given-names>Peter</given-names></name><xref rid="A5" ref-type="aff">5</xref><xref rid="A21" ref-type="aff">21</xref></contrib><contrib contrib-type="author"><name><surname>Zompo</surname><given-names>Maria Del</given-names></name><xref rid="A24" ref-type="aff">24</xref></contrib><contrib contrib-type="author"><name><surname>Mateo</surname><given-names>Ignacio</given-names></name><xref rid="A10" ref-type="aff">10</xref></contrib><contrib contrib-type="author"><name><surname>Boada</surname><given-names>Merce</given-names></name><xref rid="A25" ref-type="aff">25</xref><xref rid="A26" ref-type="aff">26</xref></contrib><contrib contrib-type="author"><name><surname>Antunez</surname><given-names>Carmen</given-names></name><xref rid="A27" ref-type="aff">27</xref><xref rid="A28" ref-type="aff">28</xref></contrib><contrib contrib-type="author"><name><surname>Lopez-Arrieta</surname><given-names>Jesus</given-names></name><xref rid="A29" ref-type="aff">29</xref></contrib><contrib contrib-type="author"><name><surname>Epelbaum</surname><given-names>Jacques</given-names></name><xref rid="A30" ref-type="aff">30</xref></contrib><contrib contrib-type="author"><name><surname>Schjeide</surname><given-names>Brit-Maren Michaud</given-names></name><xref rid="A31" ref-type="aff">31</xref></contrib><contrib contrib-type="author"><name><surname>Frank-Garcia</surname><given-names>Ana</given-names></name><xref rid="A32" ref-type="aff">32</xref></contrib><contrib contrib-type="author"><name><surname>Giedraitis</surname><given-names>Vilmentas</given-names></name><xref rid="A7" ref-type="aff">7</xref></contrib><contrib contrib-type="author"><name><surname>Helisalmi</surname><given-names>Seppo</given-names></name><xref rid="A9" ref-type="aff">9</xref></contrib><contrib 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contrib-type="author"><name><surname>Lathrop</surname><given-names>Mark</given-names></name><xref rid="A37" ref-type="aff">37</xref><xref rid="A38" ref-type="aff">38</xref></contrib><contrib contrib-type="author"><name><surname>Scarpini</surname><given-names>Elio</given-names></name><xref rid="A39" ref-type="aff">39</xref></contrib><contrib contrib-type="author"><name><surname>Siciliano</surname><given-names>Gabriele</given-names></name><xref rid="A40" ref-type="aff">40</xref></contrib><contrib contrib-type="author"><name><surname>Solfrizzi</surname><given-names>Vincenzo</given-names></name><xref rid="A41" ref-type="aff">41</xref></contrib><contrib contrib-type="author"><name><surname>Sorbi</surname><given-names>Sandro</given-names></name><xref rid="A42" ref-type="aff">42</xref></contrib><contrib contrib-type="author"><name><surname>Spalletta</surname><given-names>Gianfranco</given-names></name><xref rid="A43" ref-type="aff">43</xref></contrib><contrib contrib-type="author"><name><surname>Ravaglia</surname><given-names>Giovanni</given-names></name><xref rid="A35" ref-type="aff">35</xref></contrib><contrib contrib-type="author"><name><surname>Valdivieso</surname><given-names>Fernando</given-names></name><xref rid="A11" ref-type="aff">11</xref></contrib><contrib contrib-type="author"><name><surname>Vepsäläinen</surname><given-names>Saila</given-names></name><xref rid="A9" ref-type="aff">9</xref></contrib><contrib contrib-type="author"><name><surname>Alvarez</surname><given-names>Victoria</given-names></name><xref rid="A23" ref-type="aff">23</xref></contrib><contrib contrib-type="author"><name><surname>Bosco</surname><given-names>Paolo</given-names></name><xref rid="A36" ref-type="aff">36</xref></contrib><contrib contrib-type="author"><name><surname>Mancuso</surname><given-names>Michelangelo</given-names></name><xref rid="A17" ref-type="aff">17</xref></contrib><contrib contrib-type="author"><name><surname>Panza</surname><given-names>Francesco</given-names></name><xref rid="A40" ref-type="aff">40</xref></contrib><contrib contrib-type="author"><name><surname>Nacmias</surname><given-names>Benedetta</given-names></name><xref rid="A41" ref-type="aff">41</xref></contrib><contrib contrib-type="author"><name><surname>Bossù</surname><given-names>Paola</given-names></name><xref rid="A42" ref-type="aff">42</xref></contrib><contrib contrib-type="author"><name><surname>Hanon</surname><given-names>Olivier</given-names></name><xref rid="A30" ref-type="aff">30</xref></contrib><contrib contrib-type="author"><name><surname>Piccardi</surname><given-names>Paola</given-names></name><xref rid="A24" ref-type="aff">24</xref></contrib><contrib contrib-type="author"><name><surname>Annoni</surname><given-names>Giorgio</given-names></name><xref rid="A43" ref-type="aff">43</xref></contrib><contrib contrib-type="author"><name><surname>Mann</surname><given-names>David</given-names></name><xref rid="A44" ref-type="aff">44</xref></contrib><contrib contrib-type="author"><name><surname>Marambaud</surname><given-names>Philippe</given-names></name><xref rid="A45" ref-type="aff">45</xref><xref rid="A46" ref-type="aff">46</xref></contrib><contrib contrib-type="author"><name><surname>Seripa</surname><given-names>Davide</given-names></name><xref rid="A34" ref-type="aff">34</xref></contrib><contrib contrib-type="author"><name><surname>Galimberti</surname><given-names>Daniela</given-names></name><xref rid="A39" ref-type="aff">39</xref></contrib><contrib contrib-type="author"><name><surname>Tanzi</surname><given-names>Rudolph E</given-names></name><xref rid="A47" ref-type="aff">47</xref></contrib><contrib contrib-type="author"><name><surname>Bertram</surname><given-names>Lars</given-names></name><xref rid="A31" ref-type="aff">31</xref></contrib><contrib contrib-type="author"><name><surname>Lendon</surname><given-names>Corinne</given-names></name><xref rid="A48" ref-type="aff">48</xref></contrib><contrib contrib-type="author"><name><surname>Lannfelt</surname><given-names>Lars</given-names></name><xref rid="A7" ref-type="aff">7</xref></contrib><contrib contrib-type="author"><name><surname>Licastro</surname><given-names>Federico</given-names></name><xref rid="A33" ref-type="aff">33</xref></contrib><contrib contrib-type="author"><name><surname>Campion</surname><given-names>Dominique</given-names></name><xref rid="A15" ref-type="aff">15</xref></contrib><contrib contrib-type="author"><name><surname>Pericak-Vance</surname><given-names>Margaret A</given-names></name><xref rid="A8" ref-type="aff">8</xref></contrib><contrib contrib-type="author"><name><surname>Soininen</surname><given-names>Hilkka</given-names></name><xref rid="A9" ref-type="aff">9</xref></contrib><contrib contrib-type="author"><name><surname>Van Broeckhoven</surname><given-names>Christine</given-names></name><xref rid="A4" ref-type="aff">4</xref><xref rid="A5" ref-type="aff">5</xref></contrib><contrib contrib-type="author"><name><surname>Alpérovitch</surname><given-names>Annick</given-names></name><xref rid="A19" ref-type="aff">19</xref><xref rid="A20" ref-type="aff">20</xref></contrib><contrib contrib-type="author"><name><surname>Ruiz</surname><given-names>Agustin</given-names></name><xref rid="A6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Kamboh</surname><given-names>M Ilyas</given-names></name><xref rid="A49" ref-type="aff">49</xref></contrib><contrib contrib-type="author"><name><surname>Amouyel</surname><given-names>Philippe</given-names></name><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref><xref rid="A3" ref-type="aff">3</xref><xref rid="A13" ref-type="aff">13</xref></contrib></contrib-group><aff id="A1"><label>1</label> INSERM U744, F-59019 Lille, France</aff><aff id="A2"><label>2</label> Institut Pasteur de Lille, F-59019, Lille, France</aff><aff id="A3"><label>3</label> Université de Lille Nord de France, F-59000 Lille, France</aff><aff id="A4"><label>4</label> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</aff><aff id="A5"><label>5</label> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</aff><aff id="A6"><label>6</label> Department of Structural Genomics. Neocodex, Sevilla, Spain</aff><aff id="A7"><label>7</label> Uppsala University, Stockholm, Sweden</aff><aff id="A8"><label>8</label> John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, USA</aff><aff id="A9"><label>9</label> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio, Finland</aff><aff id="A10"><label>10</label> Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain</aff><aff id="A11"><label>11</label> Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) and CIBERNED, Universidad Autonoma, Cantoblanco, S-28049, Madrid, Spain</aff><aff id="A12"><label>12</label> INSERM U888, Hôpital La Colombière, F-34093 Montpellier, France</aff><aff id="A13"><label>13</label> CHRU de Lille, F-59000 Lille, France</aff><aff id="A14"><label>14</label> University of Virginia School of medicine, Charlottesville, VA, USA</aff><aff id="A15"><label>15</label> INSERM U614, Faculté de Médecine-Pharmacie de Rouen, F-76183, Rouen, France</aff><aff id="A16"><label>16</label> Vanderbilt Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, USA</aff><aff id="A17"><label>17</label> Department of Neuroscience, Neurological Clinic, University of Pisa, I-56100, Italy</aff><aff id="A18"><label>18</label> INSERM U897, Victor Segalen University, F-33076, Bordeaux, France</aff><aff id="A19"><label>19</label> INSERM U708, F-75013 Paris, France</aff><aff id="A20"><label>20</label> UPMC Univ. Paris 06, F-75005 Paris, France</aff><aff id="A21"><label>21</label> Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen, Belgium</aff><aff id="A22"><label>22</label> Department of Internal Medicine, Fondazione Policlinico IRCCS, Milan Italy</aff><aff id="A23"><label>23</label> Genetic Molecular Unit, Hospital Universitario Central de Asturias, 33006-Oviedo, Spain</aff><aff id="A24"><label>24</label> Section of Clinical Pharmacology, Department of Neuroscience, University of Cagliari, Italy</aff><aff id="A25"><label>25</label> Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</aff><aff id="A26"><label>26</label> Neurology Department, Hospital G. Universitari Vall d’Hebron, Barcelona, Spain</aff><aff id="A27"><label>27</label> Alzheimur Foundation, Murcia, Spain</aff><aff id="A28"><label>28</label> Dementia Unit. University Hospital Virgen de la Arrixaca, Murcia, Spain</aff><aff id="A29"><label>29</label> Memory Unit. University Hospital La Paz- Cantoblanco, Madrid, Spain</aff><aff id="A30"><label>30</label> UMR 894, INSERM Faculté de Médecine, Université Paris Descartes, F-75014 Paris, France</aff><aff id="A31"><label>31</label> Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin, Germany</aff><aff id="A32"><label>32</label> Servicio de Neurologia, Hospital Universitario La Paz (UAM) and CIBERNED, 28034 Madrid, Spain</aff><aff id="A33"><label>33</label> Department of Experimental Pathology, School of Medicine, University of Bologna, Italy</aff><aff id="A34"><label>34</label> Geriatric Unit & Gerontology-Geriatric Research Laboratory, Department of Medical Science, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo , I-71013, Italy</aff><aff id="A35"><label>35</label> Department of Internal Medicine Cardiology and Hepatology, University Hospital S. Orsola-Malpighi, Bologna, Italy</aff><aff id="A36"><label>36</label> IRCCS Oasi Maria SS, 94018 Troina , Italy</aff><aff id="A37"><label>37</label> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry, France</aff><aff id="A38"><label>38</label> Fondation Jean Dausset-CEPH, Paris, France</aff><aff id="A39"><label>39</label> Dept. of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy</aff><aff id="A40"><label>40</label> Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, 70124 Bari, Italy</aff><aff id="A41"><label>41</label> Department of Neurological and Psychiatric Sciences, 50134 Florence, Italy</aff><aff id="A42"><label>42</label> Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, 00179 Roma – Italy</aff><aff id="A43"><label>43</label> Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Monza Italy</aff><aff id="A44"><label>44</label> Greater Manchester Neuroscience Centre, University of Manchester, Manchester, UK</aff><aff id="A45"><label>45</label> Litwin-Zucker Research Center for the Study of Alzheimer's Disease, Feinstein Institute for Medical Research, North Shore-LIJ, Manhasset, NY, USA</aff><aff id="A46"><label>46</label> Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA</aff><aff id="A47"><label>47</label> Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, MA 02129</aff><aff id="A48"><label>48</label> Molecular Psychiatry Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029, Australia</aff><aff id="A49"><label>49</label> Department of Human Genetics and Alzheimer's Disease Research Centre, University of Pittsburgh, USA</aff><author-notes><corresp id="FN1">Address correspondence to: Jean-Charles Lambert, Unité INSERM 744, Institut Pasteur de Lille, BP 245,1, rue du professeur Calmette, F-59019 Lille cedex, France, Tel.: +33 (0)3 20 87 73 91, Fax: +33 (0)3 20 87 78 94, <email>jean-charles.lambert@pasteur-lille.fr</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>5</day><month>10</month><year>2010</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>1</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>1</month><year>2011</year></pub-date><volume>22</volume><issue>1</issue><fpage>247</fpage><lpage>255</lpage><abstract><p id="P1">The only established genetic determinant of non-Mendelian forms of Alzheimer’s disease (AD) is the ε4 allele of the apolipoprotein E gene (<italic>APOE</italic>). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (<italic>CALHM1</italic>) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centres in Belgium, Finland, France, Italy, Spain, Sweden, the UK and the USA). Our results indicate that the <italic>CALHM1</italic> P86L polymorphism is likely not a genetic determinant of AD but may modulate age at onset by interacting with the effect of the ε4 allele of the <italic>APOE</italic> gene.</p></abstract><contract-num rid="AG1">R01 AG030653-02
||AG</contract-num><contract-num rid="AG1">P50 AG005133-219007
||AG</contract-num><contract-sponsor id="AG1">National Institute on Aging : NIA</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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