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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>AURKA</italic>
F31I Polymorphism and Breast Cancer Risk in <italic>BRCA1</italic>
and <italic>BRCA2</italic>
Mutation Carriers: A CIMBA study</title>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name>
<affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sinilnikova, Olga" sort="Sinilnikova, Olga" uniqKey="Sinilnikova O" first="Olga" last="Sinilnikova">Olga Sinilnikova</name>
<affiliation><nlm:aff id="A2">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, Lyon, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vierkant, Robert A" sort="Vierkant, Robert A" uniqKey="Vierkant R" first="Robert A" last="Vierkant">Robert A. Vierkant</name>
<affiliation><nlm:aff id="A3">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V. Shane" last="Pankratz">V. Shane Pankratz</name>
<affiliation><nlm:aff id="A3">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fredericksen, Zachary S" sort="Fredericksen, Zachary S" uniqKey="Fredericksen Z" first="Zachary S." last="Fredericksen">Zachary S. Fredericksen</name>
<affiliation><nlm:aff id="A3">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name>
<affiliation><nlm:aff id="A4">INSERM U509, Service de Génétique Oncologique, Institut Curie, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Coupier, Isabelle" sort="Coupier, Isabelle" uniqKey="Coupier I" first="Isabelle" last="Coupier">Isabelle Coupier</name>
<affiliation><nlm:aff id="A4">INSERM U509, Service de Génétique Oncologique, Institut Curie, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hughes, David" sort="Hughes, David" uniqKey="Hughes D" first="David" last="Hughes">David Hughes</name>
<affiliation><nlm:aff id="A5">International Agency for Research on Cancer, Lyon, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hardouin, Agnes" sort="Hardouin, Agnes" uniqKey="Hardouin A" first="Agnès" last="Hardouin">Agnès Hardouin</name>
<affiliation><nlm:aff id="A6">Centre François Baclesse, Caen, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name>
<affiliation><nlm:aff id="A6">Centre François Baclesse, Caen, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name>
<affiliation><nlm:aff id="A7">Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cook, Margaret" sort="Cook, Margaret" uniqKey="Cook M" first="Margaret" last="Cook">Margaret Cook</name>
<affiliation><nlm:aff id="A7">Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name>
<affiliation><nlm:aff id="A8">Cancer Research U.K., Human Cancer Genetics Group, Department of Oncology, University of Cambridge, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hodgson, Shirley" sort="Hodgson, Shirley" uniqKey="Hodgson S" first="Shirley" last="Hodgson">Shirley Hodgson</name>
<affiliation><nlm:aff id="A9">South West Thames Regional Genetics Service, St Georges Hospital, London, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Morrison, Patrick J" sort="Morrison, Patrick J" uniqKey="Morrison P" first="Patrick J." last="Morrison">Patrick J. Morrison</name>
<affiliation><nlm:aff id="A10">Northern Ireland Regional Genetics Centre, Cancer Genetics Service, Belfast City Hospital, Belfast, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Porteous, Mary E" sort="Porteous, Mary E" uniqKey="Porteous M" first="Mary E." last="Porteous">Mary E. Porteous</name>
<affiliation><nlm:aff id="A11">South East of Scotland Clinical Genetics Service, Western General Hospital, Edinburgh, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
<affiliation><nlm:aff id="A12">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
<affiliation><nlm:aff id="A12">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name>
<affiliation><nlm:aff id="A12">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name>
<affiliation><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schmutzler, Rita" sort="Schmutzler, Rita" uniqKey="Schmutzler R" first="Rita" last="Schmutzler">Rita Schmutzler</name>
<affiliation><nlm:aff id="A15">Division of Molecular Gyneco-Oncology, University of Cologne, Cologne, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Versmold, Beatrix" sort="Versmold, Beatrix" uniqKey="Versmold B" first="Beatrix" last="Versmold">Beatrix Versmold</name>
<affiliation><nlm:aff id="A15">Division of Molecular Gyneco-Oncology, University of Cologne, Cologne, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name>
<affiliation><nlm:aff id="A16">Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation><nlm:aff id="A17">Department of Gynaecology and Obstetrics, Technical University, Munich, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name>
<affiliation><nlm:aff id="A18">Institute of Human Genetics, University of Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Horst, Jurgen" sort="Horst, Jurgen" uniqKey="Horst J" first="Jurgen" last="Horst">Jurgen Horst</name>
<affiliation><nlm:aff id="A19">Institute of Human Genetics, University of Muenster, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schaefer, Dieter" sort="Schaefer, Dieter" uniqKey="Schaefer D" first="Dieter" last="Schaefer">Dieter Schaefer</name>
<affiliation><nlm:aff id="A20">Institute of Human Genetics, University of Frankfurt, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name>
<affiliation><nlm:aff id="A21">Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kirchhoff, Tomas" sort="Kirchhoff, Tomas" uniqKey="Kirchhoff T" first="Tomas" last="Kirchhoff">Tomas Kirchhoff</name>
<affiliation><nlm:aff id="A21">Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<affiliation><nlm:aff id="A22">Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A23">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ilyushik, Eduard" sort="Ilyushik, Eduard" uniqKey="Ilyushik E" first="Eduard" last="Ilyushik">Eduard Ilyushik</name>
<affiliation><nlm:aff id="A22">Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Glendon, Gordon" sort="Glendon, Gordon" uniqKey="Glendon G" first="Gordon" last="Glendon">Gordon Glendon</name>
<affiliation><nlm:aff id="A23">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<affiliation><nlm:aff id="A24">Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vreeswijk, Maaike P G" sort="Vreeswijk, Maaike P G" uniqKey="Vreeswijk M" first="Maaike P. G." last="Vreeswijk">Maaike P. G. Vreeswijk</name>
<affiliation><nlm:aff id="A24">Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vasen, Hans F A" sort="Vasen, Hans F A" uniqKey="Vasen H" first="Hans F. A." last="Vasen">Hans F. A. Vasen</name>
<affiliation><nlm:aff id="A25">The Foundation for the Detection of Hereditary Tumors, Leiden, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Borg, Ake" sort="Borg, Ake" uniqKey="Borg A" first="Ake" last="Borg">Ake Borg</name>
<affiliation><nlm:aff id="A26">Department of Oncology, Lund University Hospital, Lund, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Backenhorn, Katja" sort="Backenhorn, Katja" uniqKey="Backenhorn K" first="Katja" last="Backenhorn">Katja Backenhorn</name>
<affiliation><nlm:aff id="A26">Department of Oncology, Lund University Hospital, Lund, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Struewing, Jeffery P" sort="Struewing, Jeffery P" uniqKey="Struewing J" first="Jeffery P." last="Struewing">Jeffery P. Struewing</name>
<affiliation><nlm:aff id="A27">Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name>
<affiliation><nlm:aff id="A28">Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name>
<affiliation><nlm:aff id="A29">Division of Epidemiology, Department of Medicine, University of California Irvine, Irvine, CA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name>
<affiliation><nlm:aff id="A30">Abramson Cancer Center, University of Pennsylvania School of Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nathanson, Katherine" sort="Nathanson, Katherine" uniqKey="Nathanson K" first="Katherine" last="Nathanson">Katherine Nathanson</name>
<affiliation><nlm:aff id="A30">Abramson Cancer Center, University of Pennsylvania School of Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Domchek, Susan" sort="Domchek, Susan" uniqKey="Domchek S" first="Susan" last="Domchek">Susan Domchek</name>
<affiliation><nlm:aff id="A30">Abramson Cancer Center, University of Pennsylvania School of Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wagner, Theresa" sort="Wagner, Theresa" uniqKey="Wagner T" first="Theresa" last="Wagner">Theresa Wagner</name>
<affiliation><nlm:aff id="A31">Division of Senology, Medical University of Vienna, Austria</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Garber, Judy E" sort="Garber, Judy E" uniqKey="Garber J" first="Judy E." last="Garber">Judy E. Garber</name>
<affiliation><nlm:aff id="A32">Dana-Farber Cancer Institute, Boston, MA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Szabo, Csilla" sort="Szabo, Csilla" uniqKey="Szabo C" first="Csilla" last="Szabo">Csilla Szabo</name>
<affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zikan, Michal" sort="Zikan, Michal" uniqKey="Zikan M" first="Michal" last="Zikan">Michal Zikan</name>
<affiliation><nlm:aff id="A33">Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name>
<affiliation><nlm:aff id="A34">Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name>
<affiliation><nlm:aff id="A3">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name>
<affiliation><nlm:aff id="A35">Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lindor, Noralane" sort="Lindor, Noralane" uniqKey="Lindor N" first="Noralane" last="Lindor">Noralane Lindor</name>
<affiliation><nlm:aff id="A36">Department of Medical Genetics, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation><nlm:aff id="A37">Department of Obstetrics and Gynecology (JT, HN), Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tommiska, Johanna" sort="Tommiska, Johanna" uniqKey="Tommiska J" first="Johanna" last="Tommiska">Johanna Tommiska</name>
<affiliation><nlm:aff id="A37">Department of Obstetrics and Gynecology (JT, HN), Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aittomaki, Kristiina" sort="Aittomaki, Kristiina" uniqKey="Aittomaki K" first="Kristiina" last="Aittomaki">Kristiina Aittomaki</name>
<affiliation><nlm:aff id="A38">Department of Clinical Genetics (KA), Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation><nlm:aff id="A39">Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rashid, Muhammad U" sort="Rashid, Muhammad U" uniqKey="Rashid M" first="Muhammad U." last="Rashid">Muhammad U. Rashid</name>
<affiliation><nlm:aff id="A39">Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name>
<affiliation><nlm:aff id="A39">Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<affiliation><nlm:aff id="A40">Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Durocher, Francine" sort="Durocher, Francine" uniqKey="Durocher F" first="Francine" last="Durocher">Francine Durocher</name>
<affiliation><nlm:aff id="A40">Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Guenard, Frederic" sort="Guenard, Frederic" uniqKey="Guenard F" first="Frederic" last="Guenard">Frederic Guenard</name>
<affiliation><nlm:aff id="A40">Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lynch, Henry T" sort="Lynch, Henry T" uniqKey="Lynch H" first="Henry T." last="Lynch">Henry T. Lynch</name>
<affiliation><nlm:aff id="A41">Department of Preventive Medicine and Public Health, Creighton University, Omaha, NE</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name>
<affiliation><nlm:aff id="A42">Lombardi Cancer Center, Georgetown University, Washington, DC</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Weitzel, Jeffrey" sort="Weitzel, Jeffrey" uniqKey="Weitzel J" first="Jeffrey" last="Weitzel">Jeffrey Weitzel</name>
<affiliation><nlm:aff id="A43">City of Hope Cancer Center, Duarte, CA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name>
<affiliation><nlm:aff id="A44">University of Chicago, Chicago, IL</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Narod, Steven" sort="Narod, Steven" uniqKey="Narod S" first="Steven" last="Narod">Steven Narod</name>
<affiliation><nlm:aff id="A45">Centre for Research in Women's Health, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name>
<affiliation><nlm:aff id="A46">Fox Chase Cancer Center, Philadelphia, PA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name>
<affiliation><nlm:aff id="A46">Fox Chase Cancer Center, Philadelphia, PA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tomlinson, Gail" sort="Tomlinson, Gail" uniqKey="Tomlinson G" first="Gail" last="Tomlinson">Gail Tomlinson</name>
<affiliation><nlm:aff id="A47">University of Texas Southwestern Medical Center at Dallas, Dallas, TX</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation><nlm:aff id="A7">Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Antoniouon, Antonis C" sort="Antoniouon, Antonis C" uniqKey="Antoniouon A" first="Antonis C." last="Antoniouon">Antonis C. Antoniouon</name>
<affiliation><nlm:aff id="A7">Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">17627006</idno>
<idno type="pmc">2775799</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775799</idno>
<idno type="RBID">PMC:2775799</idno>
<idno type="doi">10.1158/1055-9965.EPI-07-0129</idno>
<date when="2007">2007</date>
<idno type="wicri:Area/Pmc/Corpus">001473</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001473</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>AURKA</italic>
F31I Polymorphism and Breast Cancer Risk in <italic>BRCA1</italic>
and <italic>BRCA2</italic>
Mutation Carriers: A CIMBA study</title>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name>
<affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sinilnikova, Olga" sort="Sinilnikova, Olga" uniqKey="Sinilnikova O" first="Olga" last="Sinilnikova">Olga Sinilnikova</name>
<affiliation><nlm:aff id="A2">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, Lyon, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vierkant, Robert A" sort="Vierkant, Robert A" uniqKey="Vierkant R" first="Robert A" last="Vierkant">Robert A. Vierkant</name>
<affiliation><nlm:aff id="A3">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V. Shane" last="Pankratz">V. Shane Pankratz</name>
<affiliation><nlm:aff id="A3">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fredericksen, Zachary S" sort="Fredericksen, Zachary S" uniqKey="Fredericksen Z" first="Zachary S." last="Fredericksen">Zachary S. Fredericksen</name>
<affiliation><nlm:aff id="A3">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name>
<affiliation><nlm:aff id="A4">INSERM U509, Service de Génétique Oncologique, Institut Curie, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Coupier, Isabelle" sort="Coupier, Isabelle" uniqKey="Coupier I" first="Isabelle" last="Coupier">Isabelle Coupier</name>
<affiliation><nlm:aff id="A4">INSERM U509, Service de Génétique Oncologique, Institut Curie, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hughes, David" sort="Hughes, David" uniqKey="Hughes D" first="David" last="Hughes">David Hughes</name>
<affiliation><nlm:aff id="A5">International Agency for Research on Cancer, Lyon, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hardouin, Agnes" sort="Hardouin, Agnes" uniqKey="Hardouin A" first="Agnès" last="Hardouin">Agnès Hardouin</name>
<affiliation><nlm:aff id="A6">Centre François Baclesse, Caen, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name>
<affiliation><nlm:aff id="A6">Centre François Baclesse, Caen, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name>
<affiliation><nlm:aff id="A7">Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cook, Margaret" sort="Cook, Margaret" uniqKey="Cook M" first="Margaret" last="Cook">Margaret Cook</name>
<affiliation><nlm:aff id="A7">Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name>
<affiliation><nlm:aff id="A8">Cancer Research U.K., Human Cancer Genetics Group, Department of Oncology, University of Cambridge, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hodgson, Shirley" sort="Hodgson, Shirley" uniqKey="Hodgson S" first="Shirley" last="Hodgson">Shirley Hodgson</name>
<affiliation><nlm:aff id="A9">South West Thames Regional Genetics Service, St Georges Hospital, London, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Morrison, Patrick J" sort="Morrison, Patrick J" uniqKey="Morrison P" first="Patrick J." last="Morrison">Patrick J. Morrison</name>
<affiliation><nlm:aff id="A10">Northern Ireland Regional Genetics Centre, Cancer Genetics Service, Belfast City Hospital, Belfast, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Porteous, Mary E" sort="Porteous, Mary E" uniqKey="Porteous M" first="Mary E." last="Porteous">Mary E. Porteous</name>
<affiliation><nlm:aff id="A11">South East of Scotland Clinical Genetics Service, Western General Hospital, Edinburgh, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
<affiliation><nlm:aff id="A12">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
<affiliation><nlm:aff id="A12">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name>
<affiliation><nlm:aff id="A12">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name>
<affiliation><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schmutzler, Rita" sort="Schmutzler, Rita" uniqKey="Schmutzler R" first="Rita" last="Schmutzler">Rita Schmutzler</name>
<affiliation><nlm:aff id="A15">Division of Molecular Gyneco-Oncology, University of Cologne, Cologne, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Versmold, Beatrix" sort="Versmold, Beatrix" uniqKey="Versmold B" first="Beatrix" last="Versmold">Beatrix Versmold</name>
<affiliation><nlm:aff id="A15">Division of Molecular Gyneco-Oncology, University of Cologne, Cologne, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name>
<affiliation><nlm:aff id="A16">Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation><nlm:aff id="A17">Department of Gynaecology and Obstetrics, Technical University, Munich, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name>
<affiliation><nlm:aff id="A18">Institute of Human Genetics, University of Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Horst, Jurgen" sort="Horst, Jurgen" uniqKey="Horst J" first="Jurgen" last="Horst">Jurgen Horst</name>
<affiliation><nlm:aff id="A19">Institute of Human Genetics, University of Muenster, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schaefer, Dieter" sort="Schaefer, Dieter" uniqKey="Schaefer D" first="Dieter" last="Schaefer">Dieter Schaefer</name>
<affiliation><nlm:aff id="A20">Institute of Human Genetics, University of Frankfurt, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name>
<affiliation><nlm:aff id="A21">Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kirchhoff, Tomas" sort="Kirchhoff, Tomas" uniqKey="Kirchhoff T" first="Tomas" last="Kirchhoff">Tomas Kirchhoff</name>
<affiliation><nlm:aff id="A21">Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<affiliation><nlm:aff id="A22">Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A23">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ilyushik, Eduard" sort="Ilyushik, Eduard" uniqKey="Ilyushik E" first="Eduard" last="Ilyushik">Eduard Ilyushik</name>
<affiliation><nlm:aff id="A22">Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Glendon, Gordon" sort="Glendon, Gordon" uniqKey="Glendon G" first="Gordon" last="Glendon">Gordon Glendon</name>
<affiliation><nlm:aff id="A23">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<affiliation><nlm:aff id="A24">Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vreeswijk, Maaike P G" sort="Vreeswijk, Maaike P G" uniqKey="Vreeswijk M" first="Maaike P. G." last="Vreeswijk">Maaike P. G. Vreeswijk</name>
<affiliation><nlm:aff id="A24">Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vasen, Hans F A" sort="Vasen, Hans F A" uniqKey="Vasen H" first="Hans F. A." last="Vasen">Hans F. A. Vasen</name>
<affiliation><nlm:aff id="A25">The Foundation for the Detection of Hereditary Tumors, Leiden, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Borg, Ake" sort="Borg, Ake" uniqKey="Borg A" first="Ake" last="Borg">Ake Borg</name>
<affiliation><nlm:aff id="A26">Department of Oncology, Lund University Hospital, Lund, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Backenhorn, Katja" sort="Backenhorn, Katja" uniqKey="Backenhorn K" first="Katja" last="Backenhorn">Katja Backenhorn</name>
<affiliation><nlm:aff id="A26">Department of Oncology, Lund University Hospital, Lund, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Struewing, Jeffery P" sort="Struewing, Jeffery P" uniqKey="Struewing J" first="Jeffery P." last="Struewing">Jeffery P. Struewing</name>
<affiliation><nlm:aff id="A27">Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name>
<affiliation><nlm:aff id="A28">Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name>
<affiliation><nlm:aff id="A29">Division of Epidemiology, Department of Medicine, University of California Irvine, Irvine, CA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name>
<affiliation><nlm:aff id="A30">Abramson Cancer Center, University of Pennsylvania School of Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nathanson, Katherine" sort="Nathanson, Katherine" uniqKey="Nathanson K" first="Katherine" last="Nathanson">Katherine Nathanson</name>
<affiliation><nlm:aff id="A30">Abramson Cancer Center, University of Pennsylvania School of Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Domchek, Susan" sort="Domchek, Susan" uniqKey="Domchek S" first="Susan" last="Domchek">Susan Domchek</name>
<affiliation><nlm:aff id="A30">Abramson Cancer Center, University of Pennsylvania School of Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wagner, Theresa" sort="Wagner, Theresa" uniqKey="Wagner T" first="Theresa" last="Wagner">Theresa Wagner</name>
<affiliation><nlm:aff id="A31">Division of Senology, Medical University of Vienna, Austria</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Garber, Judy E" sort="Garber, Judy E" uniqKey="Garber J" first="Judy E." last="Garber">Judy E. Garber</name>
<affiliation><nlm:aff id="A32">Dana-Farber Cancer Institute, Boston, MA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Szabo, Csilla" sort="Szabo, Csilla" uniqKey="Szabo C" first="Csilla" last="Szabo">Csilla Szabo</name>
<affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zikan, Michal" sort="Zikan, Michal" uniqKey="Zikan M" first="Michal" last="Zikan">Michal Zikan</name>
<affiliation><nlm:aff id="A33">Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name>
<affiliation><nlm:aff id="A34">Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name>
<affiliation><nlm:aff id="A3">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name>
<affiliation><nlm:aff id="A35">Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lindor, Noralane" sort="Lindor, Noralane" uniqKey="Lindor N" first="Noralane" last="Lindor">Noralane Lindor</name>
<affiliation><nlm:aff id="A36">Department of Medical Genetics, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation><nlm:aff id="A37">Department of Obstetrics and Gynecology (JT, HN), Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tommiska, Johanna" sort="Tommiska, Johanna" uniqKey="Tommiska J" first="Johanna" last="Tommiska">Johanna Tommiska</name>
<affiliation><nlm:aff id="A37">Department of Obstetrics and Gynecology (JT, HN), Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aittomaki, Kristiina" sort="Aittomaki, Kristiina" uniqKey="Aittomaki K" first="Kristiina" last="Aittomaki">Kristiina Aittomaki</name>
<affiliation><nlm:aff id="A38">Department of Clinical Genetics (KA), Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation><nlm:aff id="A39">Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rashid, Muhammad U" sort="Rashid, Muhammad U" uniqKey="Rashid M" first="Muhammad U." last="Rashid">Muhammad U. Rashid</name>
<affiliation><nlm:aff id="A39">Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name>
<affiliation><nlm:aff id="A39">Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<affiliation><nlm:aff id="A40">Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Durocher, Francine" sort="Durocher, Francine" uniqKey="Durocher F" first="Francine" last="Durocher">Francine Durocher</name>
<affiliation><nlm:aff id="A40">Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Guenard, Frederic" sort="Guenard, Frederic" uniqKey="Guenard F" first="Frederic" last="Guenard">Frederic Guenard</name>
<affiliation><nlm:aff id="A40">Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lynch, Henry T" sort="Lynch, Henry T" uniqKey="Lynch H" first="Henry T." last="Lynch">Henry T. Lynch</name>
<affiliation><nlm:aff id="A41">Department of Preventive Medicine and Public Health, Creighton University, Omaha, NE</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name>
<affiliation><nlm:aff id="A42">Lombardi Cancer Center, Georgetown University, Washington, DC</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Weitzel, Jeffrey" sort="Weitzel, Jeffrey" uniqKey="Weitzel J" first="Jeffrey" last="Weitzel">Jeffrey Weitzel</name>
<affiliation><nlm:aff id="A43">City of Hope Cancer Center, Duarte, CA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name>
<affiliation><nlm:aff id="A44">University of Chicago, Chicago, IL</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Narod, Steven" sort="Narod, Steven" uniqKey="Narod S" first="Steven" last="Narod">Steven Narod</name>
<affiliation><nlm:aff id="A45">Centre for Research in Women's Health, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name>
<affiliation><nlm:aff id="A46">Fox Chase Cancer Center, Philadelphia, PA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name>
<affiliation><nlm:aff id="A46">Fox Chase Cancer Center, Philadelphia, PA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tomlinson, Gail" sort="Tomlinson, Gail" uniqKey="Tomlinson G" first="Gail" last="Tomlinson">Gail Tomlinson</name>
<affiliation><nlm:aff id="A47">University of Texas Southwestern Medical Center at Dallas, Dallas, TX</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation><nlm:aff id="A7">Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Antoniouon, Antonis C" sort="Antoniouon, Antonis C" uniqKey="Antoniouon A" first="Antonis C." last="Antoniouon">Antonis C. Antoniouon</name>
<affiliation><nlm:aff id="A7">Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title>
<idno type="ISSN">1055-9965</idno>
<idno type="eISSN">1538-7755</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><p id="P1">The AURKA oncogene is associated with abnormal chromosome segregation and aneuploidy and predisposition to cancer. Amplification of AURKA has been detected at higher frequency in tumors from BRCA1 and BRCA2 mutation carriers than in sporadic breast tumors, suggesting that overexpression of AURKA and inactivation of BRCA1 and BRCA2 co-operate during tumor development and progression. The F31I polymorphism in AURKA has been associated with breast cancer risk in the homozygous state in prior studies. We evaluated whether the AURKA F31I polymorphism modifies breast cancer risk in BRCA1 and BRCA2 mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). CIMBA was established to provide sufficient statistical power through increased numbers of mutation carriers to identify polymorphisms that act as modifiers of cancer risk and can refine breast cancer risk estimates in BRCA1 and BRCA2 mutation carriers. A total of 4935 BRCA1 and 2241 BRCA2 mutation carriers and 11 individuals carrying both BRCA1 and BRCA2 mutations were genotyped for F31I. Overall, homozygosity for the 31I allele was not significantly associated with breast cancer risk in BRCA1 and BRCA2 carriers combined (HR = 0.91; 95% CI 0.77-1.06). Similarly, no significant association was seen in BRCA1 (HR = 0.90; 95% CI 0.75-1.08) or BRCA2 carriers (HR = 0.93; 95% CI 0.67-1.29) or when assessing the modifying effects of either bilateral prophylactic oophorectomy or menopausal status of BRCA1 and BRCA2 carriers. In summary, the F31I polymorphism in AURKA is not associated with a modified risk of breast cancer in BRCA1 and BRCA2 carriers.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9200608</journal-id>
<journal-id journal-id-type="pubmed-jr-id">2299</journal-id>
<journal-id journal-id-type="nlm-ta">Cancer Epidemiol Biomarkers Prev</journal-id>
<journal-title>Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</journal-title>
<issn pub-type="ppub">1055-9965</issn>
<issn pub-type="epub">1538-7755</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">17627006</article-id>
<article-id pub-id-type="pmc">2775799</article-id>
<article-id pub-id-type="doi">10.1158/1055-9965.EPI-07-0129</article-id>
<article-id pub-id-type="manuscript">NIHMS123590</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title><italic>AURKA</italic>
F31I Polymorphism and Breast Cancer Risk in <italic>BRCA1</italic>
and <italic>BRCA2</italic>
Mutation Carriers: A CIMBA study</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Couch</surname>
<given-names>Fergus J.</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sinilnikova</surname>
<given-names>Olga</given-names>
</name>
<xref rid="A2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vierkant</surname>
<given-names>Robert A</given-names>
</name>
<xref rid="A3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pankratz</surname>
<given-names>V. Shane</given-names>
</name>
<xref rid="A3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fredericksen</surname>
<given-names>Zachary S.</given-names>
</name>
<xref rid="A3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stoppa-Lyonnet</surname>
<given-names>Dominique</given-names>
</name>
<xref rid="A4" ref-type="aff">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Coupier</surname>
<given-names>Isabelle</given-names>
</name>
<xref rid="A4" ref-type="aff">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hughes</surname>
<given-names>David</given-names>
</name>
<xref rid="A5" ref-type="aff">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hardouin</surname>
<given-names>Agnès</given-names>
</name>
<xref rid="A6" ref-type="aff">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Berthet</surname>
<given-names>Pascaline</given-names>
</name>
<xref rid="A6" ref-type="aff">6</xref>
</contrib>
<contrib contrib-type="author"><collab>GEMO</collab>
</contrib>
<contrib contrib-type="author"><name><surname>Peock</surname>
<given-names>Susan</given-names>
</name>
<xref rid="A7" ref-type="aff">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cook</surname>
<given-names>Margaret</given-names>
</name>
<xref rid="A7" ref-type="aff">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baynes</surname>
<given-names>Caroline</given-names>
</name>
<xref rid="A8" ref-type="aff">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hodgson</surname>
<given-names>Shirley</given-names>
</name>
<xref rid="A9" ref-type="aff">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Morrison</surname>
<given-names>Patrick J.</given-names>
</name>
<xref rid="A10" ref-type="aff">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Porteous</surname>
<given-names>Mary E.</given-names>
</name>
<xref rid="A11" ref-type="aff">11</xref>
</contrib>
<contrib contrib-type="author"><collab>EMBRACE</collab>
</contrib>
<contrib contrib-type="author"><name><surname>Jakubowska</surname>
<given-names>Anna</given-names>
</name>
<xref rid="A12" ref-type="aff">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lubinski</surname>
<given-names>Jan</given-names>
</name>
<xref rid="A12" ref-type="aff">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gronwald</surname>
<given-names>Jacek</given-names>
</name>
<xref rid="A12" ref-type="aff">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Spurdle</surname>
<given-names>Amanda B.</given-names>
</name>
<xref rid="A13" ref-type="aff">13</xref>
</contrib>
<contrib contrib-type="author"><collab>kConFab</collab>
<xref rid="A14" ref-type="aff">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schmutzler</surname>
<given-names>Rita</given-names>
</name>
<xref rid="A15" ref-type="aff">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Versmold</surname>
<given-names>Beatrix</given-names>
</name>
<xref rid="A15" ref-type="aff">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Engel</surname>
<given-names>Christoph</given-names>
</name>
<xref rid="A16" ref-type="aff">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meindl</surname>
<given-names>Alfons</given-names>
</name>
<xref rid="A17" ref-type="aff">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sutter</surname>
<given-names>Christian</given-names>
</name>
<xref rid="A18" ref-type="aff">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Horst</surname>
<given-names>Jurgen</given-names>
</name>
<xref rid="A19" ref-type="aff">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schaefer</surname>
<given-names>Dieter</given-names>
</name>
<xref rid="A20" ref-type="aff">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Offit</surname>
<given-names>Kenneth</given-names>
</name>
<xref rid="A21" ref-type="aff">21</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kirchhoff</surname>
<given-names>Tomas</given-names>
</name>
<xref rid="A21" ref-type="aff">21</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Andrulis</surname>
<given-names>Irene L.</given-names>
</name>
<xref rid="A22" ref-type="aff">22</xref>
<xref rid="A23" ref-type="aff">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ilyushik</surname>
<given-names>Eduard</given-names>
</name>
<xref rid="A22" ref-type="aff">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Glendon</surname>
<given-names>Gordon</given-names>
</name>
<xref rid="A23" ref-type="aff">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Devilee</surname>
<given-names>Peter</given-names>
</name>
<xref rid="A24" ref-type="aff">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vreeswijk</surname>
<given-names>Maaike P.G.</given-names>
</name>
<xref rid="A24" ref-type="aff">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vasen</surname>
<given-names>Hans F.A.</given-names>
</name>
<xref rid="A25" ref-type="aff">25</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Borg</surname>
<given-names>Ake</given-names>
</name>
<xref rid="A26" ref-type="aff">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Backenhorn</surname>
<given-names>Katja</given-names>
</name>
<xref rid="A26" ref-type="aff">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Struewing</surname>
<given-names>Jeffery P.</given-names>
</name>
<xref rid="A27" ref-type="aff">27</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Greene</surname>
<given-names>Mark H.</given-names>
</name>
<xref rid="A28" ref-type="aff">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Neuhausen</surname>
<given-names>Susan L.</given-names>
</name>
<xref rid="A29" ref-type="aff">29</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rebbeck</surname>
<given-names>Timothy R.</given-names>
</name>
<xref rid="A30" ref-type="aff">30</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nathanson</surname>
<given-names>Katherine</given-names>
</name>
<xref rid="A30" ref-type="aff">30</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Domchek</surname>
<given-names>Susan</given-names>
</name>
<xref rid="A30" ref-type="aff">30</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wagner</surname>
<given-names>Theresa</given-names>
</name>
<xref rid="A31" ref-type="aff">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Garber</surname>
<given-names>Judy E.</given-names>
</name>
<xref rid="A32" ref-type="aff">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Szabo</surname>
<given-names>Csilla</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zikan</surname>
<given-names>Michal</given-names>
</name>
<xref rid="A33" ref-type="aff">33</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Foretova</surname>
<given-names>Lenka</given-names>
</name>
<xref rid="A34" ref-type="aff">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Olson</surname>
<given-names>Janet E.</given-names>
</name>
<xref rid="A3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sellers</surname>
<given-names>Thomas A.</given-names>
</name>
<xref rid="A35" ref-type="aff">35</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lindor</surname>
<given-names>Noralane</given-names>
</name>
<xref rid="A36" ref-type="aff">36</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nevanlinna</surname>
<given-names>Heli</given-names>
</name>
<xref rid="A37" ref-type="aff">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tommiska</surname>
<given-names>Johanna</given-names>
</name>
<xref rid="A37" ref-type="aff">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aittomaki</surname>
<given-names>Kristiina</given-names>
</name>
<xref rid="A38" ref-type="aff">38</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hamann</surname>
<given-names>Ute</given-names>
</name>
<xref rid="A39" ref-type="aff">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rashid</surname>
<given-names>Muhammad U.</given-names>
</name>
<xref rid="A39" ref-type="aff">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Torres</surname>
<given-names>Diana</given-names>
</name>
<xref rid="A39" ref-type="aff">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Simard</surname>
<given-names>Jacques</given-names>
</name>
<xref rid="A40" ref-type="aff">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Durocher</surname>
<given-names>Francine</given-names>
</name>
<xref rid="A40" ref-type="aff">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Guenard</surname>
<given-names>Frederic</given-names>
</name>
<xref rid="A40" ref-type="aff">40</xref>
</contrib>
<contrib contrib-type="author"><collab>INHERIT BRCAs</collab>
</contrib>
<contrib contrib-type="author"><name><surname>Lynch</surname>
<given-names>Henry T.</given-names>
</name>
<xref rid="A41" ref-type="aff">41</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Isaacs</surname>
<given-names>Claudine</given-names>
</name>
<xref rid="A42" ref-type="aff">42</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Weitzel</surname>
<given-names>Jeffrey</given-names>
</name>
<xref rid="A43" ref-type="aff">43</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Olopade</surname>
<given-names>Olufunmilayo I.</given-names>
</name>
<xref rid="A44" ref-type="aff">44</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Narod</surname>
<given-names>Steven</given-names>
</name>
<xref rid="A45" ref-type="aff">45</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Daly</surname>
<given-names>Mary B.</given-names>
</name>
<xref rid="A46" ref-type="aff">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Godwin</surname>
<given-names>Andrew K.</given-names>
</name>
<xref rid="A46" ref-type="aff">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tomlinson</surname>
<given-names>Gail</given-names>
</name>
<xref rid="A47" ref-type="aff">47</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Easton</surname>
<given-names>Douglas F.</given-names>
</name>
<xref rid="A7" ref-type="aff">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chenevix-Trench</surname>
<given-names>Georgia</given-names>
</name>
<xref rid="A13" ref-type="aff">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Antoniouon</surname>
<given-names>Antonis C.</given-names>
</name>
<xref rid="A7" ref-type="aff">7</xref>
</contrib>
<on-behalf-of>on behalf of the Consortium of Investigators of Modifiers of BRCA1/2</on-behalf-of>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN</aff>
<aff id="A2"><label>2</label>
Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, Lyon, France</aff>
<aff id="A3"><label>3</label>
Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN</aff>
<aff id="A4"><label>4</label>
INSERM U509, Service de Génétique Oncologique, Institut Curie, Paris, France</aff>
<aff id="A5"><label>5</label>
International Agency for Research on Cancer, Lyon, France</aff>
<aff id="A6"><label>6</label>
Centre François Baclesse, Caen, France</aff>
<aff id="A7"><label>7</label>
Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom</aff>
<aff id="A8"><label>8</label>
Cancer Research U.K., Human Cancer Genetics Group, Department of Oncology, University of Cambridge, United Kingdom</aff>
<aff id="A9"><label>9</label>
South West Thames Regional Genetics Service, St Georges Hospital, London, United Kingdom</aff>
<aff id="A10"><label>10</label>
Northern Ireland Regional Genetics Centre, Cancer Genetics Service, Belfast City Hospital, Belfast, United Kingdom</aff>
<aff id="A11"><label>11</label>
South East of Scotland Clinical Genetics Service, Western General Hospital, Edinburgh, United Kingdom</aff>
<aff id="A12"><label>12</label>
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</aff>
<aff id="A13"><label>13</label>
Queensland Institute of Medical Research, Brisbane, Queensland, Australia</aff>
<aff id="A14"><label>14</label>
The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Centre, Melbourne, Australia</aff>
<aff id="A15"><label>15</label>
Division of Molecular Gyneco-Oncology, University of Cologne, Cologne, Germany</aff>
<aff id="A16"><label>16</label>
Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</aff>
<aff id="A17"><label>17</label>
Department of Gynaecology and Obstetrics, Technical University, Munich, Germany</aff>
<aff id="A18"><label>18</label>
Institute of Human Genetics, University of Heidelberg, Germany</aff>
<aff id="A19"><label>19</label>
Institute of Human Genetics, University of Muenster, Germany</aff>
<aff id="A20"><label>20</label>
Institute of Human Genetics, University of Frankfurt, Germany</aff>
<aff id="A21"><label>21</label>
Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY</aff>
<aff id="A22"><label>22</label>
Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</aff>
<aff id="A23"><label>23</label>
Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</aff>
<aff id="A24"><label>24</label>
Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</aff>
<aff id="A25"><label>25</label>
The Foundation for the Detection of Hereditary Tumors, Leiden, The Netherlands</aff>
<aff id="A26"><label>26</label>
Department of Oncology, Lund University Hospital, Lund, Sweden</aff>
<aff id="A27"><label>27</label>
Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD</aff>
<aff id="A28"><label>28</label>
Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</aff>
<aff id="A29"><label>29</label>
Division of Epidemiology, Department of Medicine, University of California Irvine, Irvine, CA</aff>
<aff id="A30"><label>30</label>
Abramson Cancer Center, University of Pennsylvania School of Medicine</aff>
<aff id="A31"><label>31</label>
Division of Senology, Medical University of Vienna, Austria</aff>
<aff id="A32"><label>32</label>
Dana-Farber Cancer Institute, Boston, MA</aff>
<aff id="A33"><label>33</label>
Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic</aff>
<aff id="A34"><label>34</label>
Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic</aff>
<aff id="A35"><label>35</label>
Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL</aff>
<aff id="A36"><label>36</label>
Department of Medical Genetics, Mayo Clinic College of Medicine, Rochester, MN</aff>
<aff id="A37"><label>37</label>
Department of Obstetrics and Gynecology (JT, HN), Helsinki University Central Hospital, Helsinki, Finland</aff>
<aff id="A38"><label>38</label>
Department of Clinical Genetics (KA), Helsinki University Central Hospital, Helsinki, Finland</aff>
<aff id="A39"><label>39</label>
Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg, Germany</aff>
<aff id="A40"><label>40</label>
Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada</aff>
<aff id="A41"><label>41</label>
Department of Preventive Medicine and Public Health, Creighton University, Omaha, NE</aff>
<aff id="A42"><label>42</label>
Lombardi Cancer Center, Georgetown University, Washington, DC</aff>
<aff id="A43"><label>43</label>
City of Hope Cancer Center, Duarte, CA</aff>
<aff id="A44"><label>44</label>
University of Chicago, Chicago, IL</aff>
<aff id="A45"><label>45</label>
Centre for Research in Women's Health, Toronto, Ontario, Canada</aff>
<aff id="A46"><label>46</label>
Fox Chase Cancer Center, Philadelphia, PA</aff>
<aff id="A47"><label>47</label>
University of Texas Southwestern Medical Center at Dallas, Dallas, TX</aff>
<author-notes><corresp id="FN1">Corresponding Author: Fergus J. Couch, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA, <email>Couch.fergus@mayo.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>7</day>
<month>10</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="ppub"><month>7</month>
<year>2007</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>11</day>
<month>11</month>
<year>2009</year>
</pub-date>
<volume>16</volume>
<issue>7</issue>
<fpage>1416</fpage>
<lpage>1421</lpage>
<related-article journal-id-type="nlm-ta" journal-id="Cancer Epidemiol Biomarkers Prev" related-article-type="commentary" page="2517" id="N0x1d2f660N0x2978558" xlink:href="18006949" ext-link-type="pubmed" vol="16"></related-article>
<abstract><p id="P1">The AURKA oncogene is associated with abnormal chromosome segregation and aneuploidy and predisposition to cancer. Amplification of AURKA has been detected at higher frequency in tumors from BRCA1 and BRCA2 mutation carriers than in sporadic breast tumors, suggesting that overexpression of AURKA and inactivation of BRCA1 and BRCA2 co-operate during tumor development and progression. The F31I polymorphism in AURKA has been associated with breast cancer risk in the homozygous state in prior studies. We evaluated whether the AURKA F31I polymorphism modifies breast cancer risk in BRCA1 and BRCA2 mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). CIMBA was established to provide sufficient statistical power through increased numbers of mutation carriers to identify polymorphisms that act as modifiers of cancer risk and can refine breast cancer risk estimates in BRCA1 and BRCA2 mutation carriers. A total of 4935 BRCA1 and 2241 BRCA2 mutation carriers and 11 individuals carrying both BRCA1 and BRCA2 mutations were genotyped for F31I. Overall, homozygosity for the 31I allele was not significantly associated with breast cancer risk in BRCA1 and BRCA2 carriers combined (HR = 0.91; 95% CI 0.77-1.06). Similarly, no significant association was seen in BRCA1 (HR = 0.90; 95% CI 0.75-1.08) or BRCA2 carriers (HR = 0.93; 95% CI 0.67-1.29) or when assessing the modifying effects of either bilateral prophylactic oophorectomy or menopausal status of BRCA1 and BRCA2 carriers. In summary, the F31I polymorphism in AURKA is not associated with a modified risk of breast cancer in BRCA1 and BRCA2 carriers.</p>
</abstract>
<kwd-group><kwd><italic>BRCA1</italic>
</kwd>
<kwd><italic>BRCA2</italic>
</kwd>
<kwd><italic>AURKA</italic>
</kwd>
<kwd>CIMBA</kwd>
<kwd>Breast cancer risk</kwd>
</kwd-group>
<contract-num rid="CA1">R01 CA102776-04
||CA</contract-num>
<contract-num rid="CA1">R01 CA083855-08
||CA</contract-num>
<contract-num rid="CA1">R01 CA074415-10
||CA</contract-num>
<contract-num rid="CA1">P50 CA116201-030002
||CA</contract-num>
<contract-num rid="RR1">M01 RR000043-440791
||RR</contract-num>
<contract-sponsor id="CA1">National Cancer Institute : NCI</contract-sponsor>
<contract-sponsor id="RR1">National Center for Research Resources : NCRR</contract-sponsor>
</article-meta>
</front>
</pmc>
</record>
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