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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Deafness in TRβ-mutants is caused by malformation of the tectorial membrane</title><author><name sortKey="Winter, Harald" sort="Winter, Harald" uniqKey="Winter H" first="Harald" last="Winter">Harald Winter</name><affiliation><nlm:aff id="A1">University of Tübingen, Department of Otorhinolaryngology, Tübingen Hearing Research Center (THRC), Molecular Neurobiology & Cell Biology of the Inner Ear, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ruttiger, Lukas" sort="Ruttiger, Lukas" uniqKey="Ruttiger L" first="Lukas" last="Rüttiger">Lukas Rüttiger</name><affiliation><nlm:aff id="A1">University of Tübingen, Department of Otorhinolaryngology, Tübingen Hearing Research Center (THRC), Molecular Neurobiology & Cell Biology of the Inner Ear, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Muller, Marcus" sort="Muller, Marcus" uniqKey="Muller M" first="Marcus" last="Müller">Marcus Müller</name><affiliation><nlm:aff id="A2">University of Tübingen, Department of Otorhinolaryngology, THRC, Molecular Otology, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Kuhn, Stephanie" sort="Kuhn, Stephanie" uniqKey="Kuhn S" first="Stephanie" last="Kuhn">Stephanie Kuhn</name><affiliation><nlm:aff id="A3">University of Tübingen, Institute of Physiology II and Department of Otorhinolaryngology, THRC, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Brandt, Niels" sort="Brandt, Niels" uniqKey="Brandt N" first="Niels" last="Brandt">Niels Brandt</name><affiliation><nlm:aff id="A3">University of Tübingen, Institute of Physiology II and Department of Otorhinolaryngology, THRC, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Zimmermann, Ulrike" sort="Zimmermann, Ulrike" uniqKey="Zimmermann U" first="Ulrike" last="Zimmermann">Ulrike Zimmermann</name><affiliation><nlm:aff id="A1">University of Tübingen, Department of Otorhinolaryngology, Tübingen Hearing Research Center (THRC), Molecular Neurobiology & Cell Biology of the Inner Ear, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Hirt, Bernhard" sort="Hirt, Bernhard" uniqKey="Hirt B" first="Bernhard" last="Hirt">Bernhard Hirt</name><affiliation><nlm:aff id="A4">University of Tübingen, Institute of Anatomy and Department of Otorhinolaryngology, THRC, Molecular Otology, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Bress, Andreas" sort="Bress, Andreas" uniqKey="Bress A" first="Andreas" last="Bress">Andreas Bress</name><affiliation><nlm:aff id="A5">University of Tübingen, Department of Otorhinolaryngology, THRC, Hereditary Hearing Loss, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Sausbier, Matthias" sort="Sausbier, Matthias" uniqKey="Sausbier M" first="Matthias" last="Sausbier">Matthias Sausbier</name><affiliation><nlm:aff id="A6">University of Tübingen, Institute of Pharmacy, Department of Pharmacology & Toxicology, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Conscience, Aude" sort="Conscience, Aude" uniqKey="Conscience A" first="Aude" last="Conscience">Aude Conscience</name><affiliation><nlm:aff id="A7">Institut de Génomique Fonctionnelle, Ecole Normale Supérieure de Lyon, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Monash University, Monash Immunology & Stem Cell Laboratories, Victoria 3800, Australia</nlm:aff></affiliation></author><author><name sortKey="Flamant, Frederic" sort="Flamant, Frederic" uniqKey="Flamant F" first="Frederic" last="Flamant">Frederic Flamant</name><affiliation><nlm:aff id="A7">Institut de Génomique Fonctionnelle, Ecole Normale Supérieure de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Tian, Yong" sort="Tian, Yong" uniqKey="Tian Y" first="Yong" last="Tian">Yong Tian</name><affiliation><nlm:aff id="A9">St. Jude Children's Research Hospital, Department of Developmental Neurobiology, Memphis, Tennessee, USA</nlm:aff></affiliation></author><author><name sortKey="Zuo, Jian" sort="Zuo, Jian" uniqKey="Zuo J" first="Jian" last="Zuo">Jian Zuo</name><affiliation><nlm:aff id="A9">St. Jude Children's Research Hospital, Department of Developmental Neurobiology, Memphis, Tennessee, USA</nlm:aff></affiliation></author><author><name sortKey="Pfister, Markus" sort="Pfister, Markus" uniqKey="Pfister M" first="Markus" last="Pfister">Markus Pfister</name><affiliation><nlm:aff id="A5">University of Tübingen, Department of Otorhinolaryngology, THRC, Hereditary Hearing Loss, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ruth, Peter" sort="Ruth, Peter" uniqKey="Ruth P" first="Peter" last="Ruth">Peter Ruth</name><affiliation><nlm:aff id="A6">University of Tübingen, Institute of Pharmacy, Department of Pharmacology & Toxicology, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Lowenheim, Hubert" sort="Lowenheim, Hubert" uniqKey="Lowenheim H" first="Hubert" last="Löwenheim">Hubert Löwenheim</name><affiliation><nlm:aff id="A2">University of Tübingen, Department of Otorhinolaryngology, THRC, Molecular Otology, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Samarut, Jacques" sort="Samarut, Jacques" uniqKey="Samarut J" first="Jacques" last="Samarut">Jacques Samarut</name><affiliation><nlm:aff id="A7">Institut de Génomique Fonctionnelle, Ecole Normale Supérieure de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Engel, Jutta" sort="Engel, Jutta" uniqKey="Engel J" first="Jutta" last="Engel">Jutta Engel</name><affiliation><nlm:aff id="A3">University of Tübingen, Institute of Physiology II and Department of Otorhinolaryngology, THRC, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Knipper, Marlies" sort="Knipper, Marlies" uniqKey="Knipper M" first="Marlies" last="Knipper">Marlies Knipper</name><affiliation><nlm:aff id="A1">University of Tübingen, Department of Otorhinolaryngology, Tübingen Hearing Research Center (THRC), Molecular Neurobiology & Cell Biology of the Inner Ear, Tübingen, Germany</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19244534</idno><idno type="pmc">2748340</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748340</idno><idno type="RBID">PMC:2748340</idno><idno type="doi">10.1523/JNEUROSCI.3557-08.2009</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">001460</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001460</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Deafness in TRβ-mutants is caused by malformation of the tectorial membrane</title><author><name sortKey="Winter, Harald" sort="Winter, Harald" uniqKey="Winter H" first="Harald" last="Winter">Harald Winter</name><affiliation><nlm:aff id="A1">University of Tübingen, Department of Otorhinolaryngology, Tübingen Hearing Research Center (THRC), Molecular Neurobiology & Cell Biology of the Inner Ear, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ruttiger, Lukas" sort="Ruttiger, Lukas" uniqKey="Ruttiger L" first="Lukas" last="Rüttiger">Lukas Rüttiger</name><affiliation><nlm:aff id="A1">University of Tübingen, Department of Otorhinolaryngology, Tübingen Hearing Research Center (THRC), Molecular Neurobiology & Cell Biology of the Inner Ear, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Muller, Marcus" sort="Muller, Marcus" uniqKey="Muller M" first="Marcus" last="Müller">Marcus Müller</name><affiliation><nlm:aff id="A2">University of Tübingen, Department of Otorhinolaryngology, THRC, Molecular Otology, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Kuhn, Stephanie" sort="Kuhn, Stephanie" uniqKey="Kuhn S" first="Stephanie" last="Kuhn">Stephanie Kuhn</name><affiliation><nlm:aff id="A3">University of Tübingen, Institute of Physiology II and Department of Otorhinolaryngology, THRC, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Brandt, Niels" sort="Brandt, Niels" uniqKey="Brandt N" first="Niels" last="Brandt">Niels Brandt</name><affiliation><nlm:aff id="A3">University of Tübingen, Institute of Physiology II and Department of Otorhinolaryngology, THRC, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Zimmermann, Ulrike" sort="Zimmermann, Ulrike" uniqKey="Zimmermann U" first="Ulrike" last="Zimmermann">Ulrike Zimmermann</name><affiliation><nlm:aff id="A1">University of Tübingen, Department of Otorhinolaryngology, Tübingen Hearing Research Center (THRC), Molecular Neurobiology & Cell Biology of the Inner Ear, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Hirt, Bernhard" sort="Hirt, Bernhard" uniqKey="Hirt B" first="Bernhard" last="Hirt">Bernhard Hirt</name><affiliation><nlm:aff id="A4">University of Tübingen, Institute of Anatomy and Department of Otorhinolaryngology, THRC, Molecular Otology, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Bress, Andreas" sort="Bress, Andreas" uniqKey="Bress A" first="Andreas" last="Bress">Andreas Bress</name><affiliation><nlm:aff id="A5">University of Tübingen, Department of Otorhinolaryngology, THRC, Hereditary Hearing Loss, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Sausbier, Matthias" sort="Sausbier, Matthias" uniqKey="Sausbier M" first="Matthias" last="Sausbier">Matthias Sausbier</name><affiliation><nlm:aff id="A6">University of Tübingen, Institute of Pharmacy, Department of Pharmacology & Toxicology, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Conscience, Aude" sort="Conscience, Aude" uniqKey="Conscience A" first="Aude" last="Conscience">Aude Conscience</name><affiliation><nlm:aff id="A7">Institut de Génomique Fonctionnelle, Ecole Normale Supérieure de Lyon, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Monash University, Monash Immunology & Stem Cell Laboratories, Victoria 3800, Australia</nlm:aff></affiliation></author><author><name sortKey="Flamant, Frederic" sort="Flamant, Frederic" uniqKey="Flamant F" first="Frederic" last="Flamant">Frederic Flamant</name><affiliation><nlm:aff id="A7">Institut de Génomique Fonctionnelle, Ecole Normale Supérieure de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Tian, Yong" sort="Tian, Yong" uniqKey="Tian Y" first="Yong" last="Tian">Yong Tian</name><affiliation><nlm:aff id="A9">St. Jude Children's Research Hospital, Department of Developmental Neurobiology, Memphis, Tennessee, USA</nlm:aff></affiliation></author><author><name sortKey="Zuo, Jian" sort="Zuo, Jian" uniqKey="Zuo J" first="Jian" last="Zuo">Jian Zuo</name><affiliation><nlm:aff id="A9">St. Jude Children's Research Hospital, Department of Developmental Neurobiology, Memphis, Tennessee, USA</nlm:aff></affiliation></author><author><name sortKey="Pfister, Markus" sort="Pfister, Markus" uniqKey="Pfister M" first="Markus" last="Pfister">Markus Pfister</name><affiliation><nlm:aff id="A5">University of Tübingen, Department of Otorhinolaryngology, THRC, Hereditary Hearing Loss, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ruth, Peter" sort="Ruth, Peter" uniqKey="Ruth P" first="Peter" last="Ruth">Peter Ruth</name><affiliation><nlm:aff id="A6">University of Tübingen, Institute of Pharmacy, Department of Pharmacology & Toxicology, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Lowenheim, Hubert" sort="Lowenheim, Hubert" uniqKey="Lowenheim H" first="Hubert" last="Löwenheim">Hubert Löwenheim</name><affiliation><nlm:aff id="A2">University of Tübingen, Department of Otorhinolaryngology, THRC, Molecular Otology, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Samarut, Jacques" sort="Samarut, Jacques" uniqKey="Samarut J" first="Jacques" last="Samarut">Jacques Samarut</name><affiliation><nlm:aff id="A7">Institut de Génomique Fonctionnelle, Ecole Normale Supérieure de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Engel, Jutta" sort="Engel, Jutta" uniqKey="Engel J" first="Jutta" last="Engel">Jutta Engel</name><affiliation><nlm:aff id="A3">University of Tübingen, Institute of Physiology II and Department of Otorhinolaryngology, THRC, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Knipper, Marlies" sort="Knipper, Marlies" uniqKey="Knipper M" first="Marlies" last="Knipper">Marlies Knipper</name><affiliation><nlm:aff id="A1">University of Tübingen, Department of Otorhinolaryngology, Tübingen Hearing Research Center (THRC), Molecular Neurobiology & Cell Biology of the Inner Ear, Tübingen, Germany</nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of neuroscience : the official journal of the Society for Neuroscience</title><idno type="ISSN">0270-6474</idno><idno type="eISSN">1529-2401</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Thyroid hormone receptor β (TRβ) dysfunction leads to deafness in humans and mice. Deafness in TRβ<sup>−/−</sup> mutant mice has been attributed to TRβ-mediated control of fast-activating BK current expression in inner hair cells (IHCs). However, normal hearing in young constitutive BKα<sup>−/−</sup> mutants contradicts this hypothesis. Here we show that mice with hair cell-specific deletion of TRβ after postnatal day (P) 11 have a delay in BKα expression but normal hearing, indicating that the origin of hearing loss in TRβ<sup>−/−</sup> mutant mice manifested before P11. Analyzing the phenotype of IHCs in constitutive TRβ<sup>−/−</sup> mice we found normal Ca<sup>2+</sup> current amplitudes, exocytosis, and shape of compound action potential waveforms. In contrast, reduced DPOAEs and cochlear microphonics associated with an abnormal structure of the tectorial membrane and enhanced tectorin levels suggest that disturbed mechanical performance is the primary cause of deafness resulting from TRβ deficiency.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8102140</journal-id><journal-id journal-id-type="pubmed-jr-id">5035</journal-id><journal-id journal-id-type="nlm-ta">J Neurosci</journal-id><journal-title>The Journal of neuroscience : the official journal of the Society for Neuroscience</journal-title><issn pub-type="ppub">0270-6474</issn><issn pub-type="epub">1529-2401</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19244534</article-id><article-id pub-id-type="pmc">2748340</article-id><article-id pub-id-type="doi">10.1523/JNEUROSCI.3557-08.2009</article-id><article-id pub-id-type="manuscript">NIHMS126791</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Deafness in TRβ-mutants is caused by malformation of the tectorial membrane</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Winter</surname><given-names>Harald</given-names></name><xref rid="A1" ref-type="aff">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Rüttiger</surname><given-names>Lukas</given-names></name><xref rid="A1" ref-type="aff">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Müller</surname><given-names>Marcus</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Kuhn</surname><given-names>Stephanie</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Brandt</surname><given-names>Niels</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Zimmermann</surname><given-names>Ulrike</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Hirt</surname><given-names>Bernhard</given-names></name><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Bress</surname><given-names>Andreas</given-names></name><xref rid="A5" ref-type="aff">5</xref></contrib><contrib contrib-type="author"><name><surname>Sausbier</surname><given-names>Matthias</given-names></name><xref rid="A6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Conscience</surname><given-names>Aude</given-names></name><xref rid="A7" ref-type="aff">7</xref><xref rid="A8" ref-type="aff">8</xref></contrib><contrib contrib-type="author"><name><surname>Flamant</surname><given-names>Frederic</given-names></name><xref rid="A7" ref-type="aff">7</xref></contrib><contrib contrib-type="author"><name><surname>Tian</surname><given-names>Yong</given-names></name><xref rid="A9" ref-type="aff">9</xref></contrib><contrib contrib-type="author"><name><surname>Zuo</surname><given-names>Jian</given-names></name><xref rid="A9" ref-type="aff">9</xref></contrib><contrib contrib-type="author"><name><surname>Pfister</surname><given-names>Markus</given-names></name><xref rid="A5" ref-type="aff">5</xref></contrib><contrib contrib-type="author"><name><surname>Ruth</surname><given-names>Peter</given-names></name><xref rid="A6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Löwenheim</surname><given-names>Hubert</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Samarut</surname><given-names>Jacques</given-names></name><xref rid="A7" ref-type="aff">7</xref></contrib><contrib contrib-type="author"><name><surname>Engel</surname><given-names>Jutta</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Knipper</surname><given-names>Marlies</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>University of Tübingen, Department of Otorhinolaryngology, Tübingen Hearing Research Center (THRC), Molecular Neurobiology & Cell Biology of the Inner Ear, Tübingen, Germany</aff><aff id="A2"><label>2</label>University of Tübingen, Department of Otorhinolaryngology, THRC, Molecular Otology, Tübingen, Germany</aff><aff id="A3"><label>3</label>University of Tübingen, Institute of Physiology II and Department of Otorhinolaryngology, THRC, Tübingen, Germany</aff><aff id="A4"><label>4</label>University of Tübingen, Institute of Anatomy and Department of Otorhinolaryngology, THRC, Molecular Otology, Tübingen, Germany</aff><aff id="A5"><label>5</label>University of Tübingen, Department of Otorhinolaryngology, THRC, Hereditary Hearing Loss, Tübingen, Germany</aff><aff id="A6"><label>6</label>University of Tübingen, Institute of Pharmacy, Department of Pharmacology & Toxicology, Tübingen, Germany</aff><aff id="A7"><label>7</label>Institut de Génomique Fonctionnelle, Ecole Normale Supérieure de Lyon, Lyon, France</aff><aff id="A8"><label>8</label>Monash University, Monash Immunology & Stem Cell Laboratories, Victoria 3800, Australia</aff><aff id="A9"><label>9</label>St. Jude Children's Research Hospital, Department of Developmental Neurobiology, Memphis, Tennessee, USA</aff><author-notes><corresp id="FN2">Corresponding Author: Prof. Dr. M. Knipper, HNO-Klinik, Hörforschungszentrum, Elfriede-Aulhorn-Str. 5, 72076 Tübingen, Germany, Phone +49 7071 2988244, Fax +49 7071 294950, <email>marlies.knipper@uni-tuebingen.de</email></corresp><fn id="FN1" fn-type="equal"><label>*</label><p>These authors contributed equally to this work</p></fn><fn id="FN3" fn-type="edited-by"><p>Senior Editor: Dr. Marie T. Filbin</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>24</day><month>8</month><year>2009</year></pub-date><pub-date pub-type="ppub"><day>25</day><month>2</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>22</day><month>9</month><year>2009</year></pub-date><volume>29</volume><issue>8</issue><fpage>2581</fpage><lpage>2587</lpage><abstract><p id="P1">Thyroid hormone receptor β (TRβ) dysfunction leads to deafness in humans and mice. Deafness in TRβ<sup>−/−</sup> mutant mice has been attributed to TRβ-mediated control of fast-activating BK current expression in inner hair cells (IHCs). However, normal hearing in young constitutive BKα<sup>−/−</sup> mutants contradicts this hypothesis. Here we show that mice with hair cell-specific deletion of TRβ after postnatal day (P) 11 have a delay in BKα expression but normal hearing, indicating that the origin of hearing loss in TRβ<sup>−/−</sup> mutant mice manifested before P11. Analyzing the phenotype of IHCs in constitutive TRβ<sup>−/−</sup> mice we found normal Ca<sup>2+</sup> current amplitudes, exocytosis, and shape of compound action potential waveforms. In contrast, reduced DPOAEs and cochlear microphonics associated with an abnormal structure of the tectorial membrane and enhanced tectorin levels suggest that disturbed mechanical performance is the primary cause of deafness resulting from TRβ deficiency.</p></abstract><kwd-group><kwd>hearing</kwd><kwd>TRβ</kwd><kwd>BK</kwd><kwd>conditional knockout mice</kwd><kwd>tectorin</kwd><kwd>exocytosis</kwd></kwd-group><contract-num rid="DC1">R21 DC008800-02</contract-num><contract-num rid="DC1">R21 DC005168-03</contract-num><contract-num rid="DC1">R01 DC006471-06</contract-num><contract-num rid="CA1">P30 CA021765-31</contract-num><contract-sponsor id="DC1">National Institute on Deafness and Other Communication Disorders : NIDCD</contract-sponsor><contract-sponsor id="CA1">National Cancer Institute : NCI</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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