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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Incidence and Risk Factors for New-Onset Diabetes in HIV-Infected Patients</title><author><name sortKey="De Wit, Stephane" sort="De Wit, Stephane" uniqKey="De Wit S" first="Stephane" last="De Wit">Stephane De Wit</name><affiliation><nlm:aff id="A1">Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A." last="Sabin">Caroline A. Sabin</name><affiliation><nlm:aff id="A2">Royal Free and University College, London, U.K.</nlm:aff></affiliation></author><author><name sortKey="Weber, Rainer" sort="Weber, Rainer" uniqKey="Weber R" first="Rainer" last="Weber">Rainer Weber</name><affiliation><nlm:aff id="A3">University Hospital Zurich, Zurich, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Worm, Signe Westring" sort="Worm, Signe Westring" uniqKey="Worm S" first="Signe Westring" last="Worm">Signe Westring Worm</name><affiliation><nlm:aff id="A4">University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name><affiliation><nlm:aff id="A5">Academic Medical Center, Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Cazanave, Charles" sort="Cazanave, Charles" uniqKey="Cazanave C" first="Charles" last="Cazanave">Charles Cazanave</name><affiliation><nlm:aff id="A6">Bordeaux 2 University, Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="El Sadr, Wafaa" sort="El Sadr, Wafaa" uniqKey="El Sadr W" first="Wafaa" last="El-Sadr">Wafaa El-Sadr</name><affiliation><nlm:aff id="A7">Columbia University, Harlem Hospital, New York, New York</nlm:aff></affiliation></author><author><name sortKey="D Rminio Monforte, Antonella" sort="D Rminio Monforte, Antonella" uniqKey="D Rminio Monforte A" first="Antonella" last="D Rminio Monforte">Antonella D Rminio Monforte</name><affiliation><nlm:aff id="A8">University of Milan, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Fontas, Eric" sort="Fontas, Eric" uniqKey="Fontas E" first="Eric" last="Fontas">Eric Fontas</name><affiliation><nlm:aff id="A9">Centre Hospitalier Universitaire Nice, Hôpital de l’Archet, Nice, France</nlm:aff></affiliation></author><author><name sortKey="Law, Matthew G" sort="Law, Matthew G" uniqKey="Law M" first="Matthew G." last="Law">Matthew G. Law</name><affiliation><nlm:aff id="A10">National Centre in HIV Epidemiology and Clinical Research, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Friis M Ller, Nina" sort="Friis M Ller, Nina" uniqKey="Friis M Ller N" first="Nina" last="Friis-M Ller">Nina Friis-M Ller</name><affiliation><nlm:aff id="A4">University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Phillips, Andrew" sort="Phillips, Andrew" uniqKey="Phillips A" first="Andrew" last="Phillips">Andrew Phillips</name><affiliation><nlm:aff id="A2">Royal Free and University College, London, U.K.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18268071</idno><idno type="pmc">2746200</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746200</idno><idno type="RBID">PMC:2746200</idno><idno type="doi">10.2337/dc07-2013</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">001456</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001456</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Incidence and Risk Factors for New-Onset Diabetes in HIV-Infected Patients</title><author><name sortKey="De Wit, Stephane" sort="De Wit, Stephane" uniqKey="De Wit S" first="Stephane" last="De Wit">Stephane De Wit</name><affiliation><nlm:aff id="A1">Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A." last="Sabin">Caroline A. Sabin</name><affiliation><nlm:aff id="A2">Royal Free and University College, London, U.K.</nlm:aff></affiliation></author><author><name sortKey="Weber, Rainer" sort="Weber, Rainer" uniqKey="Weber R" first="Rainer" last="Weber">Rainer Weber</name><affiliation><nlm:aff id="A3">University Hospital Zurich, Zurich, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Worm, Signe Westring" sort="Worm, Signe Westring" uniqKey="Worm S" first="Signe Westring" last="Worm">Signe Westring Worm</name><affiliation><nlm:aff id="A4">University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name><affiliation><nlm:aff id="A5">Academic Medical Center, Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Cazanave, Charles" sort="Cazanave, Charles" uniqKey="Cazanave C" first="Charles" last="Cazanave">Charles Cazanave</name><affiliation><nlm:aff id="A6">Bordeaux 2 University, Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="El Sadr, Wafaa" sort="El Sadr, Wafaa" uniqKey="El Sadr W" first="Wafaa" last="El-Sadr">Wafaa El-Sadr</name><affiliation><nlm:aff id="A7">Columbia University, Harlem Hospital, New York, New York</nlm:aff></affiliation></author><author><name sortKey="D Rminio Monforte, Antonella" sort="D Rminio Monforte, Antonella" uniqKey="D Rminio Monforte A" first="Antonella" last="D Rminio Monforte">Antonella D Rminio Monforte</name><affiliation><nlm:aff id="A8">University of Milan, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Fontas, Eric" sort="Fontas, Eric" uniqKey="Fontas E" first="Eric" last="Fontas">Eric Fontas</name><affiliation><nlm:aff id="A9">Centre Hospitalier Universitaire Nice, Hôpital de l’Archet, Nice, France</nlm:aff></affiliation></author><author><name sortKey="Law, Matthew G" sort="Law, Matthew G" uniqKey="Law M" first="Matthew G." last="Law">Matthew G. Law</name><affiliation><nlm:aff id="A10">National Centre in HIV Epidemiology and Clinical Research, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Friis M Ller, Nina" sort="Friis M Ller, Nina" uniqKey="Friis M Ller N" first="Nina" last="Friis-M Ller">Nina Friis-M Ller</name><affiliation><nlm:aff id="A4">University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Phillips, Andrew" sort="Phillips, Andrew" uniqKey="Phillips A" first="Andrew" last="Phillips">Andrew Phillips</name><affiliation><nlm:aff id="A2">Royal Free and University College, London, U.K.</nlm:aff></affiliation></author></analytic><series><title level="j">Diabetes care</title><idno type="ISSN">0149-5992</idno><idno type="eISSN">1935-5548</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>OBJECTIVE</title><p id="P1">The aims of this study were to determine the incidence of diabetes among HIV-infected patients in the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) cohort, to identify demographic, HIV-related, and combination antiretroviral therapy (cART)-related factors associated with the onset of diabetes, and to identify possible mechanisms for any relationships found.</p></sec><sec id="S2"><title>RESEARCH DESIGN AND METHODS</title><p id="P2">D:A:D is a prospective observational study of 33,389 HIV-infected patients; diabetes is a study end point. Poisson regression models were used to assess the relation between diabetes and exposure to cART after adjusting for known risk factors for diabetes, CD4 count, lipids, and lipodystrophy.</p></sec><sec id="S3"><title>RESULTS</title><p id="P3">Over 130,151 person-years of follow-up (PYFU), diabetes was diagnosed in 744 patients (incidence rate of 5.72 per 1,000 PYFU [95% CI 5.31–6.13]). The incidence of diabetes increased with cumulative exposure to cART, an association that remained significant after adjustment for potential risk factors for diabetes. The strongest relationship with diabetes was exposure to stavudine; exposures to zidovudine and didanosine were also associated with an increased risk of diabetes. Time-updated measurements of total cholesterol, HDL cholesterol, and triglycerides were all associated with diabetes. Adjusting for each of these variables separately reduced the relationship between cART and diabetes slightly. Although lipodystrophy was significantly associated with diabetes, adjustment for this did not modify the relationship between cART and diabetes.</p></sec><sec id="S4"><title>CONCLUSION</title><p id="P4">Stavudine and zidovudine are significantly associated with diabetes after adjustment for risk factors for diabetes and lipids. Adjustment for lipodystrophy did not modify the relationship, suggesting that the two thymidine analogs probably directly contribute to insulin resistance, potentially through mitochondrial toxicity.</p></sec></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7805975</journal-id><journal-id journal-id-type="pubmed-jr-id">3416</journal-id><journal-id journal-id-type="nlm-ta">Diabetes Care</journal-id><journal-title>Diabetes care</journal-title><issn pub-type="ppub">0149-5992</issn><issn pub-type="epub">1935-5548</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18268071</article-id><article-id pub-id-type="pmc">2746200</article-id><article-id pub-id-type="manuscript">NIHMS113884</article-id><article-id pub-id-type="doi">10.2337/dc07-2013</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Incidence and Risk Factors for New-Onset Diabetes in HIV-Infected Patients</article-title><subtitle>The Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study</subtitle></title-group><contrib-group><contrib contrib-type="author"><name><surname>De Wit</surname><given-names>Stephane</given-names></name><degrees>MD, PHD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sabin</surname><given-names>Caroline A.</given-names></name><degrees>PHD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Weber</surname><given-names>Rainer</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Worm</surname><given-names>Signe Westring</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Reiss</surname><given-names>Peter</given-names></name><degrees>MD, PHD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Cazanave</surname><given-names>Charles</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>El-Sadr</surname><given-names>Wafaa</given-names></name><degrees>MD, MPH</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>D’Arminio Monforte</surname><given-names>Antonella</given-names></name><degrees>MD, DMSC</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Fontas</surname><given-names>Eric</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Law</surname><given-names>Matthew G.</given-names></name><degrees>PHD</degrees><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Friis-MØller</surname><given-names>Nina</given-names></name><degrees>MD, PHD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Phillips</surname><given-names>Andrew</given-names></name><degrees>PHD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium</aff><aff id="A2"><label>2</label>Royal Free and University College, London, U.K.</aff><aff id="A3"><label>3</label>University Hospital Zurich, Zurich, Switzerland</aff><aff id="A4"><label>4</label>University of Copenhagen, Copenhagen, Denmark</aff><aff id="A5"><label>5</label>Academic Medical Center, Amsterdam, the Netherlands</aff><aff id="A6"><label>6</label>Bordeaux 2 University, Bordeaux, France</aff><aff id="A7"><label>7</label>Columbia University, Harlem Hospital, New York, New York</aff><aff id="A8"><label>8</label>University of Milan, Milan, Italy</aff><aff id="A9"><label>9</label>Centre Hospitalier Universitaire Nice, Hôpital de l’Archet, Nice, France</aff><aff id="A10"><label>10</label>National Centre in HIV Epidemiology and Clinical Research, Sydney, Australia</aff><author-notes><corresp id="cor1">Corresponding author: Stéphane De Wit, MD, PhD, Department of Infectious Diseases, St. Pierre University Hospital, 322, rue Haute, B-1000 Brussels, Belgium. E-mail: <email>stephane_dewit@stpierre-bru.be</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>7</day><month>5</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>11</day><month>2</month><year>2008</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>17</day><month>9</month><year>2009</year></pub-date><volume>31</volume><issue>6</issue><fpage>1224</fpage><lpage>1229</lpage><permissions><copyright-statement>© 2008 by the American Diabetes Association</copyright-statement><copyright-year>2008</copyright-year></permissions><related-article journal-id-type="nlm-ta" journal-id="Diabetes Care" related-article-type="commentary" page="1267" id="N0x1e0dc40N0x28ef310" xlink:href="18509145" ext-link-type="pubmed" vol="31"></related-article><abstract><sec id="S1"><title>OBJECTIVE</title><p id="P1">The aims of this study were to determine the incidence of diabetes among HIV-infected patients in the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) cohort, to identify demographic, HIV-related, and combination antiretroviral therapy (cART)-related factors associated with the onset of diabetes, and to identify possible mechanisms for any relationships found.</p></sec><sec id="S2"><title>RESEARCH DESIGN AND METHODS</title><p id="P2">D:A:D is a prospective observational study of 33,389 HIV-infected patients; diabetes is a study end point. Poisson regression models were used to assess the relation between diabetes and exposure to cART after adjusting for known risk factors for diabetes, CD4 count, lipids, and lipodystrophy.</p></sec><sec id="S3"><title>RESULTS</title><p id="P3">Over 130,151 person-years of follow-up (PYFU), diabetes was diagnosed in 744 patients (incidence rate of 5.72 per 1,000 PYFU [95% CI 5.31–6.13]). The incidence of diabetes increased with cumulative exposure to cART, an association that remained significant after adjustment for potential risk factors for diabetes. The strongest relationship with diabetes was exposure to stavudine; exposures to zidovudine and didanosine were also associated with an increased risk of diabetes. Time-updated measurements of total cholesterol, HDL cholesterol, and triglycerides were all associated with diabetes. Adjusting for each of these variables separately reduced the relationship between cART and diabetes slightly. Although lipodystrophy was significantly associated with diabetes, adjustment for this did not modify the relationship between cART and diabetes.</p></sec><sec id="S4"><title>CONCLUSION</title><p id="P4">Stavudine and zidovudine are significantly associated with diabetes after adjustment for risk factors for diabetes and lipids. Adjustment for lipodystrophy did not modify the relationship, suggesting that the two thymidine analogs probably directly contribute to insulin resistance, potentially through mitochondrial toxicity.</p></sec></abstract><contract-num rid="AI1">U01 AI069907-02</contract-num><contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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