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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuronal Damage in the Preterm Baboon: Impact of the Mode of Ventilatory Support</title><author><name sortKey="Verney, Catherine" sort="Verney, Catherine" uniqKey="Verney C" first="Catherine" last="Verney">Catherine Verney</name><affiliation><nlm:aff id="A1">Inserm, U676, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Paris 7, Faculté de Médecine Denis Diderot, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3">PremUP, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Rees, Sandra" sort="Rees, Sandra" uniqKey="Rees S" first="Sandra" last="Rees">Sandra Rees</name><affiliation><nlm:aff id="A4">Department of Anatomy and Cell Biology, University of Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Biran, Valerie" sort="Biran, Valerie" uniqKey="Biran V" first="Valérie" last="Biran">Valérie Biran</name><affiliation><nlm:aff id="A1">Inserm, U676, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Paris 7, Faculté de Médecine Denis Diderot, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3">PremUP, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Thompson, Merran" sort="Thompson, Merran" uniqKey="Thompson M" first="Merran" last="Thompson">Merran Thompson</name><affiliation><nlm:aff id="A5">Clinical Sciences Division, Imperial College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Inder, Terrie" sort="Inder, Terrie" uniqKey="Inder T" first="Terrie" last="Inder">Terrie Inder</name><affiliation><nlm:aff id="A6">Department of Pediatrics, Neurology and Radiology, St. Louis Children’s Hospital, Washington University, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Gressens, Pierre" sort="Gressens, Pierre" uniqKey="Gressens P" first="Pierre" last="Gressens">Pierre Gressens</name><affiliation><nlm:aff id="A1">Inserm, U676, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Paris 7, Faculté de Médecine Denis Diderot, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3">PremUP, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Institute for Reproductive and Developmental Biology, Imperial College, London, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20418779</idno><idno type="pmc">3034245</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034245</idno><idno type="RBID">PMC:3034245</idno><idno type="doi">10.1097/NEN.0b013e3181dac07b</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">001450</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001450</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Neuronal Damage in the Preterm Baboon: Impact of the Mode of Ventilatory Support</title><author><name sortKey="Verney, Catherine" sort="Verney, Catherine" uniqKey="Verney C" first="Catherine" last="Verney">Catherine Verney</name><affiliation><nlm:aff id="A1">Inserm, U676, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Paris 7, Faculté de Médecine Denis Diderot, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3">PremUP, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Rees, Sandra" sort="Rees, Sandra" uniqKey="Rees S" first="Sandra" last="Rees">Sandra Rees</name><affiliation><nlm:aff id="A4">Department of Anatomy and Cell Biology, University of Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Biran, Valerie" sort="Biran, Valerie" uniqKey="Biran V" first="Valérie" last="Biran">Valérie Biran</name><affiliation><nlm:aff id="A1">Inserm, U676, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Paris 7, Faculté de Médecine Denis Diderot, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3">PremUP, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Thompson, Merran" sort="Thompson, Merran" uniqKey="Thompson M" first="Merran" last="Thompson">Merran Thompson</name><affiliation><nlm:aff id="A5">Clinical Sciences Division, Imperial College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Inder, Terrie" sort="Inder, Terrie" uniqKey="Inder T" first="Terrie" last="Inder">Terrie Inder</name><affiliation><nlm:aff id="A6">Department of Pediatrics, Neurology and Radiology, St. Louis Children’s Hospital, Washington University, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Gressens, Pierre" sort="Gressens, Pierre" uniqKey="Gressens P" first="Pierre" last="Gressens">Pierre Gressens</name><affiliation><nlm:aff id="A1">Inserm, U676, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Paris 7, Faculté de Médecine Denis Diderot, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3">PremUP, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Institute for Reproductive and Developmental Biology, Imperial College, London, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of neuropathology and experimental neurology</title><idno type="ISSN">0022-3069</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">We evaluated the impact of randomized ventilatory strategies on specific neuronal populations of the cerebral cortex of preterm baboons. In the first series, baboons (n = 5) were delivered at 125 days of gestation (dg; term = 185 days) and exposed to 14 days of positive pressure ventilation (PPV) and compared to 140 dg controls (n = 6). In the second series, baboons were delivered at 125 dg and ventilated by either (i) PPV for 1 day followed by 27 days of nasal continuous positive airway pressure (early [EnCPAP]; n = 6) or (ii) PPV for 5 days followed by 23 days of CPAP (delayed [DnCPAP]; n = 4). Gestational controls were delivered at 153 dg (n = 3). The density of immunoreactive neurons for calretinin and somatostatin was assessed in the primary and secondary visual cortices, cingulate and parietal cortices and subiculum in paraffin sections. Compared to gestational controls, PPV for 14 days resulted in a reduction in the density of calretinin+ cells in the visual cortex (areas 17 and 18) but not in the other cortical areas. No effect of PPV was observed on somatostatin+ cells. DnCPAP, but not EnCPAP, was associated with a reduction in the density of calretinin and somatostatin+ cells in the visual cortical areas but not in the other cortical areas compared to gestational controls. Taken together, these data demonstrate that ventilatory strategies involving > 5 days of PPV have a regionally selective impact on cortical neuronal subpopulations within the visual area but not in areas of association cortex in a non-human primate model of prematurity.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">2985192R</journal-id><journal-id journal-id-type="pubmed-jr-id">5012</journal-id><journal-id journal-id-type="nlm-ta">J Neuropathol Exp Neurol</journal-id><journal-title>Journal of neuropathology and experimental neurology</journal-title><issn pub-type="ppub">0022-3069</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20418779</article-id><article-id pub-id-type="pmc">3034245</article-id><article-id pub-id-type="doi">10.1097/NEN.0b013e3181dac07b</article-id><article-id pub-id-type="manuscript">NIHMS259779</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Neuronal Damage in the Preterm Baboon: Impact of the Mode of Ventilatory Support</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Verney</surname><given-names>Catherine</given-names></name><degrees>PharmD, PhD</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Rees</surname><given-names>Sandra</given-names></name><degrees>PhD, MSc, MPhil</degrees><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Biran</surname><given-names>Valérie</given-names></name><degrees>MD, PhD</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Thompson</surname><given-names>Merran</given-names></name><degrees>MBChB</degrees><xref rid="A5" ref-type="aff">5</xref></contrib><contrib contrib-type="author"><name><surname>Inder</surname><given-names>Terrie</given-names></name><degrees>MD, PhD</degrees><xref rid="A6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Gressens</surname><given-names>Pierre</given-names></name><degrees>MD, PhD</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref><xref rid="A3" ref-type="aff">3</xref><xref rid="A7" ref-type="aff">7</xref></contrib></contrib-group><aff id="A1"><label>1</label>Inserm, U676, Paris, France</aff><aff id="A2"><label>2</label>Université Paris 7, Faculté de Médecine Denis Diderot, Paris, France</aff><aff id="A3"><label>3</label>PremUP, Paris, France</aff><aff id="A4"><label>4</label>Department of Anatomy and Cell Biology, University of Melbourne, Victoria, Australia</aff><aff id="A5"><label>5</label>Clinical Sciences Division, Imperial College, London, UK</aff><aff id="A6"><label>6</label>Department of Pediatrics, Neurology and Radiology, St. Louis Children’s Hospital, Washington University, St. Louis, MO</aff><aff id="A7"><label>7</label>Institute for Reproductive and Developmental Biology, Imperial College, London, UK</aff><author-notes><corresp id="FN1">Send correspondence and reprint requests to: Dr. Pierre Gressens, Inserm U 676, Hôpital Robert Debré, 48 Blvd. Sérurier, F-75019 Paris, France. Ph: +33 1 40 03 19 76; fax: +33 1 40 03 19 95; <email>pierre.gressens@inserm.fr</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>26</day><month>1</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>5</month><year>2011</year></pub-date><volume>69</volume><issue>5</issue><fpage>473</fpage><lpage>482</lpage><abstract><p id="P1">We evaluated the impact of randomized ventilatory strategies on specific neuronal populations of the cerebral cortex of preterm baboons. In the first series, baboons (n = 5) were delivered at 125 days of gestation (dg; term = 185 days) and exposed to 14 days of positive pressure ventilation (PPV) and compared to 140 dg controls (n = 6). In the second series, baboons were delivered at 125 dg and ventilated by either (i) PPV for 1 day followed by 27 days of nasal continuous positive airway pressure (early [EnCPAP]; n = 6) or (ii) PPV for 5 days followed by 23 days of CPAP (delayed [DnCPAP]; n = 4). Gestational controls were delivered at 153 dg (n = 3). The density of immunoreactive neurons for calretinin and somatostatin was assessed in the primary and secondary visual cortices, cingulate and parietal cortices and subiculum in paraffin sections. Compared to gestational controls, PPV for 14 days resulted in a reduction in the density of calretinin+ cells in the visual cortex (areas 17 and 18) but not in the other cortical areas. No effect of PPV was observed on somatostatin+ cells. DnCPAP, but not EnCPAP, was associated with a reduction in the density of calretinin and somatostatin+ cells in the visual cortical areas but not in the other cortical areas compared to gestational controls. Taken together, these data demonstrate that ventilatory strategies involving > 5 days of PPV have a regionally selective impact on cortical neuronal subpopulations within the visual area but not in areas of association cortex in a non-human primate model of prematurity.</p></abstract><kwd-group><kwd>Cerebral palsy</kwd><kwd>Continuous positive airway pressure (CPAP)</kwd><kwd>Cortex</kwd><kwd>Interneurons</kwd></kwd-group><contract-num rid="HL1">U01 HL052636-06
||HL</contract-num><contract-num rid="HL1">R01 HL074942-04
||HL</contract-num><contract-num rid="HL1">R01 HL074942-03
||HL</contract-num><contract-num rid="HL1">R01 HL074942-02
||HL</contract-num><contract-num rid="HL1">R01 HL074942-01A1
||HL</contract-num><contract-num rid="RR1">P51 RR013986-07
||RR</contract-num><contract-sponsor id="HL1">National Heart, Lung, and Blood Institute : NHLBI</contract-sponsor><contract-sponsor id="RR1">National Center for Research Resources : NCRR</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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